OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC6468656	For each combination of primers, the kinetics of PCR amplification was studied.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "each", "combination", "of", "primers", ",", "the", "kinetics", "of", "PCR", "amplification", "was", "studied", "." ] } ]
PMC10993311	The confounding variables included maternal age, pre-pregnancy BMI, gestational weight gain, gestational age, and neonate sex.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "confounding", "variables", "included", "maternal", "age", ",", "pre-pregnancy", "BMI", ",", "gestational", "weight", "gain", ",", "gestational", "age", ",", "and", "neonate", "sex", "." ] } ]
PMC11604830	In particular, in the representative slice reported in Figure 3, the amount of PFCE‐NE protons corresponded to 9% of the injected dose (0.057 mmol), a reasonable value considering that the imaged slice represented ca.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "particular", ",", "in", "the", "representative", "slice", "reported", "in", "Figure", "3", ",", "the", "amount", "of", "PFCE‐NE", "protons", "corresponded", "to", "9", "%", "of", "the", "injected", "dose", "(", "0.057", "mmol", ")", ",", "a", "reasonable", "value", "considering", "that", "the", "imaged", "slice", "represented", "ca", "." ] } ]
PMC10743717	It was further stated in the questionable ABAD/ERAB report that the data analysis was “using a one-site model by the method of Klotz and Hunston”.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "was", "further", "stated", "in", "the", "questionable", "ABAD/ERAB", "report", "that", "the", "data", "analysis", "was", "“", "using", "a", "one-site", "model", "by", "the", "method", "of", "Klotz", "and", "Hunston", "”", "." ] } ]
PMC10873328	Currently, high-throughput sequencing complimented with integrated big-data analysis have gradually become more and more important applications for medical research, which can effectively identify biomarkers for diagnosis, clinical stratification, prognosis and recurrence monitoring et al.. Bioinformatic analysis focusing on one biophysical, biochemical or biologic feature of OC will help to explore key targets in OC progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Currently", ",", "high-throughput", "sequencing", "complimented", "with", "integrated", "big-data", "analysis", "have", "gradually", "become", "more", "and", "more", "important", "applications", "for", "medical", "research", ",", "which", "can", "effectively", "identify", "biomarkers", "for", "diagnosis", ",", "clinical", "stratification", ",", "prognosis", "and", "recurrence", "monitoring", "et", "al", "..", "Bioinformatic", "analysis", "focusing", "on", "one", "biophysical", ",", "biochemical", "or", "biologic", "feature", "of", "OC", "will", "help", "to", "explore", "key", "targets", "in", "OC", "progression", "." ] } ]
PMC9693627	BN-PAGE was performed as described in .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BN-PAGE", "was", "performed", "as", "described", "in", "." ] } ]
PMC11777207	Gated on live, MHC class II high, and CD11c. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gated", "on", "live", ",", "MHC", "class", "II", "high", ",", "and", "CD11c", ".", "(" ] } ]
PMC11033180	Protein concentration was quantified using the BCA protein assay (cat: 23225, Thermo Fisher Scientific, Cillebon sur Yvette, France).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "concentration", "was", "quantified", "using", "the", "BCA", "protein", "assay", "(", "cat", ":", "23225", ",", "Thermo", "Fisher", "Scientific", ",", "Cillebon", "sur", "Yvette", ",", "France", ")", "." ] } ]
PMC9681981	Electrophoresis of PCR products of C. perfringens type D. First Lane: Ladder 100 bp, Lane 1: α-toxin gene (124 bp), Lane 2: ε-toxin gene (121 bp), Lane 3: β-toxin gene, Lane 4: β-toxin gene, as positive control (1421 bp), and Lane 5: No template control (NTC) Microscopic images of contacted and non-contacted cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Electrophoresis", "of", "PCR", "products", "of", "C.", "perfringens", "type", "D.", "First", "Lane", ":", "Ladder", "100", "bp", ",", "Lane", "1", ":", "α-toxin", "gene", "(", "124", "bp", ")", ",", "Lane", "2", ":", "ε-toxin", "gene", "(", "121", "bp", ")", ",", "Lane", "3", ":", "β-toxin", "gene", ",", "Lane", "4", ":", "β-toxin", "gene", ",", "as", "positive", "control", "(", "1421", "bp", ")", ",", "and", "Lane", "5", ":", "No", "template", "control", "(", "NTC", ")", "Microscopic", "images", "of", "contacted", "and", "non-contacted", "cells", "." ] } ]
PMC5386478	Transamidating activity was however abolished when spheroids were incubated with a ten times (i.e., 250 μM) higher dose of R281 (Supplementary Figure S3A), even though neither spheroids viability nor PARP cleavage or AKT phosphorylation resulted compromised (Supplementary Figure S3B and C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transamidating", "activity", "was", "however", "abolished", "when", "spheroids", "were", "incubated", "with", "a", "ten", "times", "(", "i.e.", ",", "250", "μM", ")", "higher", "dose", "of", "R281", "(", "Supplementary", "Figure", "S3A", ")", ",", "even", "though", "neither", "spheroids", "viability", "nor", "PARP", "cleavage", "or", "AKT", "phosphorylation", "resulted", "compromised", "(", "Supplementary", "Figure", "S3B", "and", "C", ")", "." ] } ]
PMC11730311	Substituting alanine with serine at position 36 resulted in a ~ 4 fold gain of potency.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Substituting", "alanine", "with", "serine", "at", "position", "36", "resulted", "in", "a", "~", "4", "fold", "gain", "of", "potency", "." ] } ]
PMC7154001	Four main factors were found to influence metabolite formation, including species, gender, and route and dose of drug administration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Four", "main", "factors", "were", "found", "to", "influence", "metabolite", "formation", ",", "including", "species", ",", "gender", ",", "and", "route", "and", "dose", "of", "drug", "administration", "." ] } ]
PMC11224206	In this opinion paper, factors determining the maintenance of temperature in preimplantation embryos are examined, a topic which has assumed special significance due to the impact of heat stress on reproductive medicine associated with climate change and global warming .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "opinion", "paper", ",", "factors", "determining", "the", "maintenance", "of", "temperature", "in", "preimplantation", "embryos", "are", "examined", ",", "a", "topic", "which", "has", "assumed", "special", "significance", "due", "to", "the", "impact", "of", "heat", "stress", "on", "reproductive", "medicine", "associated", "with", "climate", "change", "and", "global", "warming", "." ] } ]
PMC11591038	Hypoxia-inducible factor-1 (HIF-1) is a transcription factor critical for tissue adaption to low-oxygen tension.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hypoxia-inducible", "factor-1", "(", "HIF-1", ")", "is", "a", "transcription", "factor", "critical", "for", "tissue", "adaption", "to", "low-oxygen", "tension", "." ] } ]
PMC10778532	It is well established that VHL mutations contribute to tumorigenesis and influence the ccRCC development in VHL disease .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "well", "established", "that", "VHL", "mutations", "contribute", "to", "tumorigenesis", "and", "influence", "the", "ccRCC", "development", "in", "VHL", "disease", "." ] } ]
PMC10976516	Similarly, enzymatic conversion of carbohydrate groups on the MSC and T cell subset-expressed glycoprotein CD44 to the sialyl-Lewis X epitope allowed CD44 to bind to E-selectin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "enzymatic", "conversion", "of", "carbohydrate", "groups", "on", "the", "MSC", "and", "T", "cell", "subset-expressed", "glycoprotein", "CD44", "to", "the", "sialyl-Lewis", "X", "epitope", "allowed", "CD44", "to", "bind", "to", "E-selectin", "." ] } ]
PMC11725127	KRAS protein is an essential molecular switch governing cell growth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "KRAS", "protein", "is", "an", "essential", "molecular", "switch", "governing", "cell", "growth", "." ] } ]
PMC8873393	P values are calculated by student’s t-Test, n.s P = 0.382, P = 0.013, P = 0.005, *P = 4.66e.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "values", "are", "calculated", "by", "student", "’s", "t-Test", ",", "n.s", "P", "=", "0.382", ",", "", "P", "=", "0.013", ",", "", "", "P", "=", "0.005", ",", "", "*", "P", "=", "4.66e", "." ] } ]
PMC10135767	As a result, a marked reduction in the number of firm adhesion cells was observed (Figure S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "result", ",", "a", "marked", "reduction", "in", "the", "number", "of", "firm", "adhesion", "cells", "was", "observed", "(", "Figure", "S1", ")", "." ] } ]
PMC11535726	Saprobic on unidentified decaying wood.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Saprobic", "on", "unidentified", "decaying", "wood", "." ] } ]
PMC11629461	Alternatively, Matrix‐gel was used at the same concentration as Cell‐Tak.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Alternatively", ",", "Matrix‐gel", "was", "used", "at", "the", "same", "concentration", "as", "Cell‐Tak", "." ] } ]
PMC11637716	To assess the effect of the EFL1 variants, we established a patient‐derived EBV (Epstein Barr virus)‐infected B‐lymphoblastoid cell line (B‐LCL) and an SV40‐transformed fibroblast cell line (SV40‐FB).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "assess", "the", "effect", "of", "the", "EFL1", "variants", ",", "we", "established", "a", "patient‐derived", "EBV", "(", "Epstein", "Barr", "virus)‐infected", "B‐lymphoblastoid", "cell", "line", "(", "B‐LCL", ")", "and", "an", "SV40‐transformed", "fibroblast", "cell", "line", "(", "SV40‐FB", ")", "." ] } ]
PMC11519077	According to three of our previous studies, AD-MSC, BM-MSC, and MB-MSC were isolated and cultured using the same methodology, and cells were verified by inverted microscope for morphology and real-time PCR for triple differentiation ability into chondrocyte, osteocyte, and adipocyte lineages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "three", "of", "our", "previous", "studies", ",", "AD-MSC", ",", "BM-MSC", ",", "and", "MB-MSC", "were", "isolated", "and", "cultured", "using", "the", "same", "methodology", ",", "and", "cells", "were", "verified", "by", "inverted", "microscope", "for", "morphology", "and", "real-time", "PCR", "for", "triple", "differentiation", "ability", "into", "chondrocyte", ",", "osteocyte", ",", "and", "adipocyte", "lineages", "." ] } ]
PMC11723947	Bone marrow was isolated from C57BL/6 J (H2) and B6D2F1 (H2) mice by centrifugation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bone", "marrow", "was", "isolated", "from", "C57BL/6", "J", "(", "H2", ")", "and", "B6D2F1", "(", "H2", ")", "mice", "by", "centrifugation", "." ] } ]
PMC9454178	C Time-response curves of GIST-T1 and GIST-882 cells upon treatment with THZ1 at concentrations as low as 25, 50, and 100 nmol/L. D Flow cytometry analysis in GIST cells treated with THZ1 at the indicated concentrations or vehicle.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "Time-response", "curves", "of", "GIST-T1", "and", "GIST-882", "cells", "upon", "treatment", "with", "THZ1", "at", "concentrations", "as", "low", "as", "25", ",", "50", ",", "and", "100", "nmol/L.", "D", "Flow", "cytometry", "analysis", "in", "GIST", "cells", "treated", "with", "THZ1", "at", "the", "indicated", "concentrations", "or", "vehicle", "." ] } ]
PMC2777936	Expression levels of FZD7 measured by real-time-RT-PCR assays were reduced to between 15-30% of control levels in NT2/D1-R1, Tera-1 and 833K cells (Figure 6a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "levels", "of", "FZD7", "measured", "by", "real-time-RT-PCR", "assays", "were", "reduced", "to", "between", "15", "-", "30", "%", "of", "control", "levels", "in", "NT2/D1-R1", ",", "Tera-1", "and", "833", "K", "cells", "(", "Figure", "6a", ")", "." ] } ]
PMC11767725	In a 2020 study investigating a phage called SaGU1, scientists observed a sharp reduction in S. aureus populations both in vitro and on the skin of atopic mouse models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "a", "2020", "study", "investigating", "a", "phage", "called", "SaGU1", ",", "scientists", "observed", "a", "sharp", "reduction", "in", "S.", "aureus", "populations", "both", "in", "vitro", "and", "on", "the", "skin", "of", "atopic", "mouse", "models", "." ] } ]
PMC9429973	In addition, patient-derived xenografts were employed to study IL21 effect on stem cell frequency and AML engraftment capacity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "patient-derived", "xenografts", "were", "employed", "to", "study", "IL21", "effect", "on", "stem", "cell", "frequency", "and", "AML", "engraftment", "capacity", "." ] } ]
PMC9429973	Moreover, we observed an increased number of CD34 colony-forming cells (CFCs) when co-cultured with AML-MSCs with respect to h-MSCs, suggesting the maintenance of more immature hematopoietic cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "we", "observed", "an", "increased", "number", "of", "CD34", "colony-forming", "cells", "(", "CFCs", ")", "when", "co-cultured", "with", "AML-MSCs", "with", "respect", "to", "h-MSCs", ",", "suggesting", "the", "maintenance", "of", "more", "immature", "hematopoietic", "cells", "." ] } ]
PMC9429973	All pts provided informed consent.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "pts", "provided", "informed", "consent", "." ] } ]
PMC6379402	We generate SF networks starting from small seed networks (one edge), to which nodes are added based on the “rich-get-richer” principle: new nodes are attached to the existing nodes of the network with the probability proportional to their degrees.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "generate", "SF", "networks", "starting", "from", "small", "seed", "networks", "(", "one", "edge", ")", ",", "to", "which", "nodes", "are", "added", "based", "on", "the", "“", "rich-get-richer", "”", "principle", ":", "new", "nodes", "are", "attached", "to", "the", "existing", "nodes", "of", "the", "network", "with", "the", "probability", "proportional", "to", "their", "degrees", "." ] } ]
PMC11507371	Thus, heightened basal Nrf2 activation in cancer cells is frequently observed, facilitating tumour progression and resistance to therapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "heightened", "basal", "Nrf2", "activation", "in", "cancer", "cells", "is", "frequently", "observed", ",", "facilitating", "tumour", "progression", "and", "resistance", "to", "therapy", "." ] } ]
PMC11513571	Our data suggest that TSLP can be used as a strong mucosal adjuvant for vaccine development against MERS-CoV infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "data", "suggest", "that", "TSLP", "can", "be", "used", "as", "a", "strong", "mucosal", "adjuvant", "for", "vaccine", "development", "against", "MERS-CoV", "infection", "." ] } ]
PMC11343332	A scratch wound healing assay was performed to evaluate the anti-migrative potential of pycnogenol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "scratch", "wound", "healing", "assay", "was", "performed", "to", "evaluate", "the", "anti-migrative", "potential", "of", "pycnogenol", "." ] } ]
PMC11470381	A. A cell ROI is fitted into an ellipse and its shape parameters are measured.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A.", "A", "cell", "ROI", "is", "fitted", "into", "an", "ellipse", "and", "its", "shape", "parameters", "are", "measured", "." ] } ]
PMC11659921	A, B) PCR was performed to detect the transcript levels of ANGPTL4, COL8A2, CX3CR1, ERBB2, JUP, and TNFSF11 in A2780 and HEY cell lines. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "A", ",", "B", ")", "PCR", "was", "performed", "to", "detect", "the", "transcript", "levels", "of", "ANGPTL4", ",", "COL8A2", ",", "CX3CR1", ",", "ERBB2", ",", "JUP", ",", "and", "TNFSF11", "in", "A2780", "and", "HEY", "cell", "lines", ".", "(" ] } ]
PMC9429973	Methods: We performed retrospective single-center study lasting from 2015 to 2022, including patients with diagnosed gastrointestinal and chronic liver disorders complicated by IDA or ACD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "We", "performed", "retrospective", "single-center", "study", "lasting", "from", "2015", "to", "2022", ",", "including", "patients", "with", "diagnosed", "gastrointestinal", "and", "chronic", "liver", "disorders", "complicated", "by", "IDA", "or", "ACD", "." ] } ]
PMC9672323	All research was performed in accordance with relevant guidelines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "research", "was", "performed", "in", "accordance", "with", "relevant", "guidelines", "." ] } ]
PMC11401358	The β-sheet, β-turn and β-antiparallel structures decreased; in contrast, the random coil conformation increased 1.5 folds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "β-sheet", ",", "β-turn", "and", "β-antiparallel", "structures", "decreased", ";", "in", "contrast", ",", "the", "random", "coil", "conformation", "increased", "1.5", "folds", "." ] } ]
PMC11676169	Mouse anti-BCAT1 (#611271; BD Pharmingen, Oxford, UK) and rabbit anti-Green Fluorescent Protein (GFP) antibody (#A-11122) were from Invitrogen.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mouse", "anti-BCAT1", "(", "#", "611271", ";", "BD", "Pharmingen", ",", "Oxford", ",", "UK", ")", "and", "rabbit", "anti-Green", "Fluorescent", "Protein", "(", "GFP", ")", "antibody", "(", "#", "A-11122", ")", "were", "from", "Invitrogen", "." ] } ]
PMC11752767	Natural killer (NK) cells interact with various immune cells to collectively enhance the immune response against tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Natural", "killer", "(", "NK", ")", "cells", "interact", "with", "various", "immune", "cells", "to", "collectively", "enhance", "the", "immune", "response", "against", "tumors", "." ] } ]
PMC11775197	Along the same lines, other studies have shown that PPARβ/δ knockout mice have an increased risk of colon cancer carcinogenesis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Along", "the", "same", "lines", ",", "other", "studies", "have", "shown", "that", "PPARβ/δ", "knockout", "mice", "have", "an", "increased", "risk", "of", "colon", "cancer", "carcinogenesis", "." ] } ]
PMC11391695	Moreover, pcDNA/PEI/NPs@M represents a promising targeted nano-therapeutic strategy for HCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "pcDNA/PEI/NPs@M", "represents", "a", "promising", "targeted", "nano-therapeutic", "strategy", "for", "HCC", "." ] } ]
PMC8303372	The pellet was then washed twice with water, recovered by centrifugation and freeze-dried.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "pellet", "was", "then", "washed", "twice", "with", "water", ",", "recovered", "by", "centrifugation", "and", "freeze-dried", "." ] } ]
PMC9429973	Similarly, in our in vitro pro-T-cell model, the TLX3 and FLT3-ITD double-positive cells outcompeted the single-positive cells after withdrawal of Il7.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "in", "our", "in", "vitro", "pro-T-cell", "model", ",", "the", "TLX3", "and", "FLT3-ITD", "double-positive", "cells", "outcompeted", "the", "single-positive", "cells", "after", "withdrawal", "of", "Il7", "." ] } ]
PMC9454852	Our previous study showed the importance of GRP78 in MPM survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "previous", "study", "showed", "the", "importance", "of", "GRP78", "in", "MPM", "survival", "." ] } ]
PMC9118379	However, the remaining 51 (15.9%) variant spectra were not supported by any OMS tool, i.e., they were unidentified or mostly identified as other wild-type peptides with modifications (Figure 2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "remaining", "51", "(", "15.9", "%", ")", "variant", "spectra", "were", "not", "supported", "by", "any", "OMS", "tool", ",", "i.e.", ",", "they", "were", "unidentified", "or", "mostly", "identified", "as", "other", "wild-type", "peptides", "with", "modifications", "(", "Figure", "2B", ")", "." ] } ]
PMC9429973	Results:: Electroporations were used to optimise chemically modified siRNA for improving PK and PD of siMA6, this data suggested that >200 nM was required to achieve 60% knockdown (KD) within 24 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", ":", "Electroporations", "were", "used", "to", "optimise", "chemically", "modified", "siRNA", "for", "improving", "PK", "and", "PD", "of", "siMA6", ",", "this", "data", "suggested", "that", ">", "200", "nM", "was", "required", "to", "achieve", "60", "%", "knockdown", "(", "KD", ")", "within", "24", "hours", "." ] } ]
PMC10565698	7 CircUSP10 promotes liver cancer growth and metastasis through miR-211-5p/TCF12/EMT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "7", "CircUSP10", "promotes", "liver", "cancer", "growth", "and", "metastasis", "through", "miR-211", "-", "5p/TCF12/EMT", "." ] } ]
PMC8998437	The C-C chemokine receptors, namely CCR1, CCR2, CCR3, and CCR5, belong to the same protein sequence homology cluster.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "C-C", "chemokine", "receptors", ",", "namely", "CCR1", ",", "CCR2", ",", "CCR3", ",", "and", "CCR5", ",", "belong", "to", "the", "same", "protein", "sequence", "homology", "cluster", "." ] } ]
PMC11400680	And finally, in Figure 6C, the segmentation performance is the lowest compared to the easy and medium levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "And", "finally", ",", "in", "Figure", "6C", ",", "the", "segmentation", "performance", "is", "the", "lowest", "compared", "to", "the", "easy", "and", "medium", "levels", "." ] } ]
PMC9429973	Considering iada’s efficacy, pharmacologic properties, its manageable toxicity and low anticipated drug-drug interactions, iada combinations may offer additional therapeutic options for AML patients in first line or in the R/R setting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Considering", "iada", "’s", "efficacy", ",", "pharmacologic", "properties", ",", "its", "manageable", "toxicity", "and", "low", "anticipated", "drug-drug", "interactions", ",", "iada", "combinations", "may", "offer", "additional", "therapeutic", "options", "for", "AML", "patients", "in", "first", "line", "or", "in", "the", "R/R", "setting", "." ] } ]
PMC2777936	Novel pharmacological tools to inhibit Wnt signalling are becoming available .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Novel", "pharmacological", "tools", "to", "inhibit", "Wnt", "signalling", "are", "becoming", "available", "." ] } ]
PMC9429973	Aims: To support the optimal management of these patients, we developed an interactive smartphone application (myTcell), which provides guidelines on pre-treatment logistics and toxicity management in an actionable format.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "support", "the", "optimal", "management", "of", "these", "patients", ",", "we", "developed", "an", "interactive", "smartphone", "application", "(", "myTcell", ")", ",", "which", "provides", "guidelines", "on", "pre-treatment", "logistics", "and", "toxicity", "management", "in", "an", "actionable", "format", "." ] } ]
PMC10847511	Association between HR-related gene alterations with locus-specific LOH and HRD score.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Association", "between", "HR-related", "gene", "alterations", "with", "locus-specific", "LOH", "and", "HRD", "score", "." ] } ]
PMC11525028	We collected osteosarcoma samples (N = 20) and adjacent normal tissues (N = 10) for RNA-seq to explore the role of RNA modification in osteosarcoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "collected", "osteosarcoma", "samples", "(", "N", "=", "20", ")", "and", "adjacent", "normal", "tissues", "(", "N", "=", "10", ")", "for", "RNA-seq", "to", "explore", "the", "role", "of", "RNA", "modification", "in", "osteosarcoma", "." ] } ]
PMC11519567	Data are mean±s.d.,	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "mean±s.d", ".", "," ] } ]
PMC10237474	Protein 9 and (D) protein 10 expressed from CHO-K1 (blue), HEK293S GnTI (red) and Expi293F GnTI (green) was analyzed by analytical SEC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "9", "and", "(", "D", ")", "protein", "10", "expressed", "from", "CHO-K1", "(", "blue", ")", ",", "HEK293S", "GnTI", "(", "red", ")", "and", "Expi293F", "GnTI", "(", "green", ")", "was", "analyzed", "by", "analytical", "SEC", "." ] } ]
PMC9429973	The proinflammatory markers were significantly higher prior to CART1 vs CART2 (Ferritin 1582 vs 529 ng/ml) and the same trend was observed for tumor volume (LDH 262 vs 133 U/l; STLV 23,3 vs 2,6 cm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "proinflammatory", "markers", "were", "significantly", "higher", "prior", "to", "CART1", "vs", "CART2", "(", "Ferritin", "1582", "vs", "529", "ng/ml", ")", "and", "the", "same", "trend", "was", "observed", "for", "tumor", "volume", "(", "LDH", "262", "vs", "133", "U/l", ";", "STLV", "23,3", "vs", "2,6", "cm", ")", "." ] } ]
PMC8345486	The Δψp changes were interpreted as a degree of plasma membrane damage since decrease in transmembrane potential accompanies disruption of the cell membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Δψp", "changes", "were", "interpreted", "as", "a", "degree", "of", "plasma", "membrane", "damage", "since", "decrease", "in", "transmembrane", "potential", "accompanies", "disruption", "of", "the", "cell", "membrane", "." ] } ]
PMC11767793	The control choice is also related to the assay endpoint and the exposure route.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "control", "choice", "is", "also", "related", "to", "the", "assay", "endpoint", "and", "the", "exposure", "route", "." ] } ]
PMC11799978	Therefore, targeting CAFs in cancer therapy demands new strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "targeting", "CAFs", "in", "cancer", "therapy", "demands", "new", "strategies", "." ] } ]
PMC11732635	Our case report supports CAR T-cell therapy as a relatively safe and effective treatment for CAEBV in children, with milder CRS compared to that observed in malignant tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "case", "report", "supports", "CAR", "T-cell", "therapy", "as", "a", "relatively", "safe", "and", "effective", "treatment", "for", "CAEBV", "in", "children", ",", "with", "milder", "CRS", "compared", "to", "that", "observed", "in", "malignant", "tumors", "." ] } ]
PMC10079526	Only pathways significantly enriched and with a fold enrichment of more than 20 are shown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Only", "pathways", "significantly", "enriched", "and", "with", "a", "fold", "enrichment", "of", "more", "than", "20", "are", "shown", "." ] } ]
PMC9429973	The patients received the first line chemotherapy according to the national MDH 2015 protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "patients", "received", "the", "first", "line", "chemotherapy", "according", "to", "the", "national", "MDH", "2015", "protocol", "." ] } ]
PMC9429973	In the HFE gene analysis, the H63D mutation was found to be heterozygous.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "HFE", "gene", "analysis", ",", "the", "H63D", "mutation", "was", "found", "to", "be", "heterozygous", "." ] } ]
PMC11733919	Interestingly, we showed that MNPs could be degraded in a lysosomal medium but not in water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "we", "showed", "that", "MNPs", "could", "be", "degraded", "in", "a", "lysosomal", "medium", "but", "not", "in", "water", "." ] } ]
PMC11742290	Table 1Summary of the functional roles of LGR5 in cancersFunctional rolesTumor TypeCell lines/Animal speciesRefProliferation and Apoptosis Transfection with LGR5-specific siRNA decreased proliferation capacity of primary astrocytesBrainAdult male Sprague–Dawley rats (n = 72): sham operation (n = 12) and contusion injury (n = 60) LGR5 silencing in U87 cells suppressed cell proliferation and cell cycle and reduced tumor-sphere formation in vitro LGR5 depletion significantly inhibited tumor orthotropic xenograft growth in vivoBrainU87 cell lineBALB/C nude mice Silencing of LGR5 by lentiviral shRNA-mediated knockdown induced apoptosis in brain CSCsBrainBrain CSC lines NCH421k and NCH441 cells LGR5 mRNA and protein activate the WNT/β-catenin signaling pathway and enhance cell proliferation by activating PKABreastBreast cancer cell line: MCF-7 LGR5 siRNA inhibited cell proliferation with induced apoptosis via suppressing the WNT/β-catenin signaling pathwayBreastBreast cancer cell lines: MCF-7, MDA-MB-231, BT-549, ZR-75–1 LGR5-KD reduced cancer clonogenicity and tumorigenesisBreastBreast cancer cell lines: MDA-ctrl and MDA-LGR5KD LGR5 does not promote Ewing sarcoma (ES) cell proliferation in vitroEwing sarcoma Bone cancer cell lines: A673 and CHLA25 Elevated LGR5 expression increased tumor sphere-forming efficiency in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "1Summary", "of", "the", "functional", "roles", "of", "LGR5", "in", "cancersFunctional", "rolesTumor", "TypeCell", "lines/Animal", "speciesRefProliferation", "and", "Apoptosis", "Transfection", "with", "LGR5-specific", "siRNA", "decreased", "proliferation", "capacity", "of", "primary", "astrocytesBrainAdult", "male", "Sprague", "–", "Dawley", "rats", "(", "n", "=", "72", "):", "sham", "operation", "(", "n", "=", "12", ")", "and", "contusion", "injury", "(", "n", "=", "60", ")", "LGR5", "silencing", "in", "U87", "cells", "suppressed", "cell", "proliferation", "and", "cell", "cycle", "and", "reduced", "tumor-sphere", "formation", "in", "vitro", "LGR5", "depletion", "significantly", "inhibited", "tumor", "orthotropic", "xenograft", "growth", "in", "vivoBrainU87", "cell", "lineBALB/C", "nude", "mice", "Silencing", "of", "LGR5", "by", "lentiviral", "shRNA-mediated", "knockdown", "induced", "apoptosis", "in", "brain", "CSCsBrainBrain", "CSC", "lines", "NCH421k", "and", "NCH441", "cells", "LGR5", "mRNA", "and", "protein", "activate", "the", "WNT/β-catenin", "signaling", "pathway", "and", "enhance", "cell", "proliferation", "by", "activating", "PKABreastBreast", "cancer", "cell", "line", ":", "MCF-7", "LGR5", "siRNA", "inhibited", "cell", "proliferation", "with", "induced", "apoptosis", "via", "suppressing", "the", "WNT/β-catenin", "signaling", "pathwayBreastBreast", "cancer", "cell", "lines", ":", "MCF-7", ",", "MDA-MB-231", ",", "BT-549", ",", "ZR-75–1", "LGR5-KD", "reduced", "cancer", "clonogenicity", "and", "tumorigenesisBreastBreast", "cancer", "cell", "lines", ":", "MDA-ctrl", "and", "MDA-LGR5KD", "LGR5", "does", "not", "promote", "Ewing", "sarcoma", "(", "ES", ")", "cell", "proliferation", "in", "vitroEwing", "sarcoma", "Bone", "cancer", "cell", "lines", ":", "A673", "and", "CHLA25", "Elevated", "LGR5", "expression", "increased", "tumor", "sphere-forming", "efficiency", "in", "vitro", "." ] } ]
PMC9429973	There were 34.21% (13/38) of patients with Ph(+), 34.21% (13/38) with extramedullary disease (EMD), 10.52% (4/38) with MLL-AF4 fusion gene (+), and 5.26% (2/38) had received HSCT prior to CAR-T therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "were", "34.21", "%", "(", "13/38", ")", "of", "patients", "with", "Ph(+", ")", ",", "34.21", "%", "(", "13/38", ")", "with", "extramedullary", "disease", "(", "EMD", ")", ",", "10.52", "%", "(", "4/38", ")", "with", "MLL-AF4", "fusion", "gene", "(", "+", ")", ",", "and", "5.26", "%", "(", "2/38", ")", "had", "received", "HSCT", "prior", "to", "CAR-T", "therapy", "." ] } ]
PMC9429973	TFR1 and FTL mRNA levels were assessed at 8h, 16h, 24h, 48h.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TFR1", "and", "FTL", "mRNA", "levels", "were", "assessed", "at", "8h", ",", "16h", ",", "24h", ",", "48h", "." ] } ]
PMC11551844	Aurimune (CYT-6091) (PEGylated) (27 nm) has completed phase I for the treatment of patients with advanced solid tumors and phase II clinical trial agreement with the National Cancer Institute (NCI) has been signed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aurimune", "(", "CYT-6091", ")", "(", "PEGylated", ")", "(", "27", "nm", ")", "has", "completed", "phase", "I", "for", "the", "treatment", "of", "patients", "with", "advanced", "solid", "tumors", "and", "phase", "II", "clinical", "trial", "agreement", "with", "the", "National", "Cancer", "Institute", "(", "NCI", ")", "has", "been", "signed", "." ] } ]
PMC11552389	On day 24 post-transplantation, tumor samples were taken and weighed. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "day", "24", "post-transplantation", ",", "tumor", "samples", "were", "taken", "and", "weighed", ".", "(" ] } ]
PMC11024707	One of the strengths is that it is one of the rare studies in the literature that compares siblings of patients with ASD with the normal group and examines the association of mi-RNAs investigated in ASD with additional problems besides the core autism symptoms, and to the best of our knowledge, it is the first study to examine the association of mi-RNAs with autistic traits.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "of", "the", "strengths", "is", "that", "it", "is", "one", "of", "the", "rare", "studies", "in", "the", "literature", "that", "compares", "siblings", "of", "patients", "with", "ASD", "with", "the", "normal", "group", "and", "examines", "the", "association", "of", "mi-RNAs", "investigated", "in", "ASD", "with", "additional", "problems", "besides", "the", "core", "autism", "symptoms", ",", "and", "to", "the", "best", "of", "our", "knowledge", ",", "it", "is", "the", "first", "study", "to", "examine", "the", "association", "of", "mi-RNAs", "with", "autistic", "traits", "." ] } ]
PMC10329237	The effect of different concentrations of (A) BLM (0.05–0.5 µg/ml), (B) LOS (0.05–1 mM), and (C) PFD (0.025–0.5 mM) on % of cell growth of A549 cell line after 48 hr post-treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "different", "concentrations", "of", "(", "A", ")", "BLM", "(", "0.05–0.5", "µg/ml", ")", ",", "(", "B", ")", "LOS", "(", "0.05–1", "mM", ")", ",", "and", "(", "C", ")", "PFD", "(", "0.025–0.5", "mM", ")", "on", "%", "of", "cell", "growth", "of", "A549", "cell", "line", "after", "48", "hr", "post-treatment", "." ] } ]
PMC5308810	On the other hand, a small percentage (4%) of the pure CXCR4 population transit to CXCR4 over time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "other", "hand", ",", "a", "small", "percentage", "(", "4", "%", ")", "of", "the", "pure", "CXCR4", "population", "transit", "to", "CXCR4", "over", "time", "." ] } ]
PMC10577955	In a 96-well tissue culture plate, all cell lines were planted at a density of 1 × 10 cells per ml (100 µl per well), and they were then allowed to grow for 24 h at 37 °C to produce a full monolayer sheet.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "a", "96-well", "tissue", "culture", "plate", ",", "all", "cell", "lines", "were", "planted", "at", "a", "density", "of", "1", "×", "10", "cells", "per", "ml", "(", "100", "µl", "per", "well", ")", ",", "and", "they", "were", "then", "allowed", "to", "grow", "for", "24", "h", "at", "37", "°", "C", "to", "produce", "a", "full", "monolayer", "sheet", "." ] } ]
PMC9429973	One patient eligible for second-line treatment refused further therapeutic measures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "patient", "eligible", "for", "second-line", "treatment", "refused", "further", "therapeutic", "measures", "." ] } ]
PMC11593084	In mAb therapy for solid tumors, trastuzumab and pertuzumab were approved by the FDA for human epidermal growth factor receptor 2 (HER2)-overexpressed breast cancer in 1998 and 2012, respectively .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "mAb", "therapy", "for", "solid", "tumors", ",", "trastuzumab", "and", "pertuzumab", "were", "approved", "by", "the", "FDA", "for", "human", "epidermal", "growth", "factor", "receptor", "2", "(HER2)-overexpressed", "breast", "cancer", "in", "1998", "and", "2012", ",", "respectively", "." ] } ]
PMC11657695	Among all these channels, the voltage-dependent potassium channels (Kv) compose one of the largest subfamilies, with over 20 channels .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "all", "these", "channels", ",", "the", "voltage-dependent", "potassium", "channels", "(", "Kv", ")", "compose", "one", "of", "the", "largest", "subfamilies", ",", "with", "over", "20", "channels", "." ] } ]
PMC11720107	In normal cells, ROS have numerous physiological and pathological functions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "normal", "cells", ",", "ROS", "have", "numerous", "physiological", "and", "pathological", "functions", "." ] } ]
PMC11388384	We used ExTrack to jointly estimate the diffusion rate of each population, the occupancy of each population, and transition rate between each population under the assumption that transitions occur at most once per 6 ms observation interval.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "ExTrack", "to", "jointly", "estimate", "the", "diffusion", "rate", "of", "each", "population", ",", "the", "occupancy", "of", "each", "population", ",", "and", "transition", "rate", "between", "each", "population", "under", "the", "assumption", "that", "transitions", "occur", "at", "most", "once", "per", "6", "ms", "observation", "interval", "." ] } ]
PMC11361748	Genes significantly up-regulated after dual TPA Tx compared to dual acetone-Tx, 24 h apart, in WT and Krt17 mouse skin (Cutoffs: FDR-adjusted P < 0.01, fold change > 8). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genes", "significantly", "up-regulated", "after", "dual", "TPA", "Tx", "compared", "to", "dual", "acetone-Tx", ",", "24", "h", "apart", ",", "in", "WT", "and", "Krt17", "mouse", "skin", "(", "Cutoffs", ":", "FDR-adjusted", "P", "<", "0.01", ",", "fold", "change", ">", "8)", ".", "(" ] } ]
PMC11772585	B The samples highlighted in red in A were magnified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "The", "samples", "highlighted", "in", "red", "in", "A", "were", "magnified", "." ] } ]
PMC10656496	With faster growth in optimized conditions, we considered the 143B cell line to be akin to the dominant population initially present at diagnosis and often more sensitive to chemotherapy which aligns with reported in vivo data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "faster", "growth", "in", "optimized", "conditions", ",", "we", "considered", "the", "143B", "cell", "line", "to", "be", "akin", "to", "the", "dominant", "population", "initially", "present", "at", "diagnosis", "and", "often", "more", "sensitive", "to", "chemotherapy", "which", "aligns", "with", "reported", "in", "vivo", "data", "." ] } ]
PMC10654497	Heatmap showing the expression relationship of the top 40 differential genes between the C1 and C2 subtypes. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Heatmap", "showing", "the", "expression", "relationship", "of", "the", "top", "40", "differential", "genes", "between", "the", "C1", "and", "C2", "subtypes", ".", "(" ] } ]
PMC9429973	Four selected drugs are under evaluation in AML-PDX models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Four", "selected", "drugs", "are", "under", "evaluation", "in", "AML-PDX", "models", "." ] } ]
PMC9503685	Encapsulation of CSA-131 in poloxamer micelles decreases cytotoxicity and increases cell membrane selectivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Encapsulation", "of", "CSA-131", "in", "poloxamer", "micelles", "decreases", "cytotoxicity", "and", "increases", "cell", "membrane", "selectivity", "." ] } ]
PMC11496728	The results indicated that the abovementioned three monoclonal strains were successfully knocked out.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "indicated", "that", "the", "abovementioned", "three", "monoclonal", "strains", "were", "successfully", "knocked", "out", "." ] } ]
PMC8389560	The solid target was placed at the bottom of a cuvette under a thin layer of water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "solid", "target", "was", "placed", "at", "the", "bottom", "of", "a", "cuvette", "under", "a", "thin", "layer", "of", "water", "." ] } ]
PMC9429973	Results: EZH2i led to a drastic increase in Oxaliplatin resistance in all tested cell lines regardless of cell type or EZH2 and H3K27 methylation status.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "EZH2i", "led", "to", "a", "drastic", "increase", "in", "Oxaliplatin", "resistance", "in", "all", "tested", "cell", "lines", "regardless", "of", "cell", "type", "or", "EZH2", "and", "H3K27", "methylation", "status", "." ] } ]
PMC6222635	The signal at δ4.43 represents the anomer hydrogen of (1→4)-linked glucose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "signal", "at", "δ4.43", "represents", "the", "anomer", "hydrogen", "of", "(1→4)-linked", "glucose", "." ] } ]
PMC9429973	Three patients with moderate PH at baseline developed variceal bleeding (2) and ascites (1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "patients", "with", "moderate", "PH", "at", "baseline", "developed", "variceal", "bleeding", "(", "2", ")", "and", "ascites", "(", "1", ")", "." ] } ]
PMC11633763	Additionally, USP22 knockdown decreased the proliferation and glycolytic rate of the osteosarcoma cell line 143B.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "B-CellLine", "O" ], "tokens": [ "Additionally", ",", "USP22", "knockdown", "decreased", "the", "proliferation", "and", "glycolytic", "rate", "of", "the", "osteosarcoma", "cell", "line", "143B", "." ] } ]
PMC9429973	Twenty patients (62.9%) had genetically confirmed HLH; Twelve (34.3%) of them had MUNC13D mutations, Three (8.6%) had STXBP2 mutation, Five (14.3%) had RAB27A mutation while four (11.4%) had secondary HLH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twenty", "patients", "(", "62.9", "%", ")", "had", "genetically", "confirmed", "HLH", ";", "Twelve", "(", "34.3", "%", ")", "of", "them", "had", "MUNC13D", "mutations", ",", "Three", "(", "8.6", "%", ")", "had", "STXBP2", "mutation", ",", "Five", "(", "14.3", "%", ")", "had", "RAB27A", "mutation", "while", "four", "(", "11.4", "%", ")", "had", "secondary", "HLH", "." ] } ]
PMC11240448	Thus, being activated by EGFR-PI3K signaling, the mTOR-PKC pair self-amplifies its signaling, generating sustained activating signals for oncogenic transformation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "being", "activated", "by", "EGFR-PI3", "K", "signaling", ",", "the", "mTOR-PKC", "pair", "self-amplifies", "its", "signaling", ",", "generating", "sustained", "activating", "signals", "for", "oncogenic", "transformation", "." ] } ]
PMC11682172	The lowest and highest boundaries of the box represent the 25 and 75 percentiles, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lowest", "and", "highest", "boundaries", "of", "the", "box", "represent", "the", "25", "and", "75", "percentiles", ",", "respectively", "." ] } ]
PMC11089031	Renal cell carcinoma (RCC) is essentially a metabolic disease characterized by a reprogramming of energetic metabolism [26–29].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Renal", "cell", "carcinoma", "(", "RCC", ")", "is", "essentially", "a", "metabolic", "disease", "characterized", "by", "a", "reprogramming", "of", "energetic", "metabolism", "[", "26–29", "]", "." ] } ]
PMC10932641	When the cell density reached about 70–80%, the cells were subcultured according at a 1:3 ratio, and counting was performed after continuous culture for three generations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "the", "cell", "density", "reached", "about", "70–80", "%", ",", "the", "cells", "were", "subcultured", "according", "at", "a", "1:3", "ratio", ",", "and", "counting", "was", "performed", "after", "continuous", "culture", "for", "three", "generations", "." ] } ]
PMC11240052	Non-viable necrotic cells, upper left (Q1), late apoptotic cells, top right (Q2), early apoptotic cells, bottom right (Q3), viable cells lower left (Q4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Non-viable", "necrotic", "cells", ",", "upper", "left", "(", "Q1", ")", ",", "late", "apoptotic", "cells", ",", "top", "right", "(", "Q2", ")", ",", "early", "apoptotic", "cells", ",", "bottom", "right", "(", "Q3", ")", ",", "viable", "cells", "lower", "left", "(", "Q4", ")", "." ] } ]
PMC7582629	The histochemical staining technique is the standard method for analyzing the cellular morphology such as size, shape and granularity, however, it suffers from some limitations and is not able to provide reliable information on the biochemical changes in or the specific immunophenotype of cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "histochemical", "staining", "technique", "is", "the", "standard", "method", "for", "analyzing", "the", "cellular", "morphology", "such", "as", "size", ",", "shape", "and", "granularity", ",", "however", ",", "it", "suffers", "from", "some", "limitations", "and", "is", "not", "able", "to", "provide", "reliable", "information", "on", "the", "biochemical", "changes", "in", "or", "the", "specific", "immunophenotype", "of", "cells", "." ] } ]

PMC6468656

For each combination of primers, the kinetics of PCR amplification was studied.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "each", "combination", "of", "primers", ",", "the", "kinetics", "of", "PCR", "amplification", "was", "studied", "." ] } ]

PMC10993311

The confounding variables included maternal age, pre-pregnancy BMI, gestational weight gain, gestational age, and neonate sex.

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PMC11604830

In particular, in the representative slice reported in Figure 3, the amount of PFCE‐NE protons corresponded to 9% of the injected dose (0.057 mmol), a reasonable value considering that the imaged slice represented ca.

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PMC10743717

It was further stated in the questionable ABAD/ERAB report that the data analysis was “using a one-site model by the method of Klotz and Hunston”.

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PMC10873328

Currently, high-throughput sequencing complimented with integrated big-data analysis have gradually become more and more important applications for medical research, which can effectively identify biomarkers for diagnosis, clinical stratification, prognosis and recurrence monitoring et al.. Bioinformatic analysis focusing on one biophysical, biochemical or biologic feature of OC will help to explore key targets in OC progression.

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PMC9693627

BN-PAGE was performed as described in .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BN-PAGE", "was", "performed", "as", "described", "in", "." ] } ]

PMC11777207

Gated on live, MHC class II high, and CD11c. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gated", "on", "live", ",", "MHC", "class", "II", "high", ",", "and", "CD11c", ".", "(" ] } ]

PMC11033180

Protein concentration was quantified using the BCA protein assay (cat: 23225, Thermo Fisher Scientific, Cillebon sur Yvette, France).

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PMC9681981

Electrophoresis of PCR products of C. perfringens type D. First Lane: Ladder 100 bp, Lane 1: α-toxin gene (124 bp), Lane 2: ε-toxin gene (121 bp), Lane 3: β-toxin gene, Lane 4: β-toxin gene, as positive control (1421 bp), and Lane 5: No template control (NTC) Microscopic images of contacted and non-contacted cells.

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PMC5386478

Transamidating activity was however abolished when spheroids were incubated with a ten times (i.e., 250 μM) higher dose of R281 (Supplementary Figure S3A), even though neither spheroids viability nor PARP cleavage or AKT phosphorylation resulted compromised (Supplementary Figure S3B and C).

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PMC11730311

Substituting alanine with serine at position 36 resulted in a ~ 4 fold gain of potency.

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PMC7154001

Four main factors were found to influence metabolite formation, including species, gender, and route and dose of drug administration.

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PMC11224206

In this opinion paper, factors determining the maintenance of temperature in preimplantation embryos are examined, a topic which has assumed special significance due to the impact of heat stress on reproductive medicine associated with climate change and global warming .

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PMC11591038

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor critical for tissue adaption to low-oxygen tension.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hypoxia-inducible", "factor-1", "(", "HIF-1", ")", "is", "a", "transcription", "factor", "critical", "for", "tissue", "adaption", "to", "low-oxygen", "tension", "." ] } ]

PMC10778532

It is well established that VHL mutations contribute to tumorigenesis and influence the ccRCC development in VHL disease .

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PMC10976516

Similarly, enzymatic conversion of carbohydrate groups on the MSC and T cell subset-expressed glycoprotein CD44 to the sialyl-Lewis X epitope allowed CD44 to bind to E-selectin.

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PMC11725127

KRAS protein is an essential molecular switch governing cell growth.

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PMC8873393

P values are calculated by student’s t-Test, n.s P = 0.382, *P = 0.013, **P = 0.005, **P = 4.66e.

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PMC10135767

As a result, a marked reduction in the number of firm adhesion cells was observed (Figure S1).

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PMC11535726

Saprobic on unidentified decaying wood.

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PMC11629461

Alternatively, Matrix‐gel was used at the same concentration as Cell‐Tak.

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PMC11637716

To assess the effect of the EFL1 variants, we established a patient‐derived EBV (Epstein Barr virus)‐infected B‐lymphoblastoid cell line (B‐LCL) and an SV40‐transformed fibroblast cell line (SV40‐FB).

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PMC11519077

According to three of our previous studies, AD-MSC, BM-MSC, and MB-MSC were isolated and cultured using the same methodology, and cells were verified by inverted microscope for morphology and real-time PCR for triple differentiation ability into chondrocyte, osteocyte, and adipocyte lineages.

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PMC11723947

Bone marrow was isolated from C57BL/6 J (H2) and B6D2F1 (H2) mice by centrifugation.

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PMC9454178

C Time-response curves of GIST-T1 and GIST-882 cells upon treatment with THZ1 at concentrations as low as 25, 50, and 100 nmol/L. D Flow cytometry analysis in GIST cells treated with THZ1 at the indicated concentrations or vehicle.

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PMC2777936

Expression levels of FZD7 measured by real-time-RT-PCR assays were reduced to between 15-30% of control levels in NT2/D1-R1, Tera-1 and 833K cells (Figure 6a).

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PMC11767725

In a 2020 study investigating a phage called SaGU1, scientists observed a sharp reduction in S. aureus populations both in vitro and on the skin of atopic mouse models.

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PMC9429973

In addition, patient-derived xenografts were employed to study IL21 effect on stem cell frequency and AML engraftment capacity.

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PMC9429973

Moreover, we observed an increased number of CD34 colony-forming cells (CFCs) when co-cultured with AML-MSCs with respect to h-MSCs, suggesting the maintenance of more immature hematopoietic cells.

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PMC9429973

All pts provided informed consent.

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PMC6379402

We generate SF networks starting from small seed networks (one edge), to which nodes are added based on the “rich-get-richer” principle: new nodes are attached to the existing nodes of the network with the probability proportional to their degrees.

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PMC11507371

Thus, heightened basal Nrf2 activation in cancer cells is frequently observed, facilitating tumour progression and resistance to therapy .

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PMC11513571

Our data suggest that TSLP can be used as a strong mucosal adjuvant for vaccine development against MERS-CoV infection.

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PMC11343332

A scratch wound healing assay was performed to evaluate the anti-migrative potential of pycnogenol.

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PMC11470381

A. A cell ROI is fitted into an ellipse and its shape parameters are measured.

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PMC11659921

A, B) PCR was performed to detect the transcript levels of ANGPTL4, COL8A2, CX3CR1, ERBB2, JUP, and TNFSF11 in A2780 and HEY cell lines. (

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PMC9429973

Methods: We performed retrospective single-center study lasting from 2015 to 2022, including patients with diagnosed gastrointestinal and chronic liver disorders complicated by IDA or ACD.

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PMC9672323

All research was performed in accordance with relevant guidelines.

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PMC11401358

The β-sheet, β-turn and β-antiparallel structures decreased; in contrast, the random coil conformation increased 1.5 folds.

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PMC11676169

Mouse anti-BCAT1 (#611271; BD Pharmingen, Oxford, UK) and rabbit anti-Green Fluorescent Protein (GFP) antibody (#A-11122) were from Invitrogen.

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PMC11752767

Natural killer (NK) cells interact with various immune cells to collectively enhance the immune response against tumors.

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PMC11775197

Along the same lines, other studies have shown that PPARβ/δ knockout mice have an increased risk of colon cancer carcinogenesis .

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PMC11391695

Moreover, pcDNA/PEI/NPs@M represents a promising targeted nano-therapeutic strategy for HCC.

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PMC8303372

The pellet was then washed twice with water, recovered by centrifugation and freeze-dried.

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PMC9429973

Similarly, in our in vitro pro-T-cell model, the TLX3 and FLT3-ITD double-positive cells outcompeted the single-positive cells after withdrawal of Il7.

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PMC9454852

Our previous study showed the importance of GRP78 in MPM survival.

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PMC9118379

However, the remaining 51 (15.9%) variant spectra were not supported by any OMS tool, i.e., they were unidentified or mostly identified as other wild-type peptides with modifications (Figure 2B).

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PMC9429973

Results:: Electroporations were used to optimise chemically modified siRNA for improving PK and PD of siMA6, this data suggested that >200 nM was required to achieve 60% knockdown (KD) within 24 hours.

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PMC10565698

7 CircUSP10 promotes liver cancer growth and metastasis through miR-211-5p/TCF12/EMT.

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PMC8998437

The C-C chemokine receptors, namely CCR1, CCR2, CCR3, and CCR5, belong to the same protein sequence homology cluster.

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PMC11400680

And finally, in Figure 6C, the segmentation performance is the lowest compared to the easy and medium levels.

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PMC9429973

Considering iada’s efficacy, pharmacologic properties, its manageable toxicity and low anticipated drug-drug interactions, iada combinations may offer additional therapeutic options for AML patients in first line or in the R/R setting.

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PMC2777936

Novel pharmacological tools to inhibit Wnt signalling are becoming available .

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PMC9429973

Aims: To support the optimal management of these patients, we developed an interactive smartphone application (myTcell), which provides guidelines on pre-treatment logistics and toxicity management in an actionable format.

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PMC10847511

Association between HR-related gene alterations with locus-specific LOH and HRD score.

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PMC11525028

We collected osteosarcoma samples (N = 20) and adjacent normal tissues (N = 10) for RNA-seq to explore the role of RNA modification in osteosarcoma.

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PMC11519567

Data are mean±s.d.,

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PMC10237474

Protein 9 and (D) protein 10 expressed from CHO-K1 (blue), HEK293S GnTI (red) and Expi293F GnTI (green) was analyzed by analytical SEC.

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PMC9429973

The proinflammatory markers were significantly higher prior to CART1 vs CART2 (Ferritin 1582 vs 529 ng/ml) and the same trend was observed for tumor volume (LDH 262 vs 133 U/l; STLV 23,3 vs 2,6 cm).

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PMC8345486

The Δψp changes were interpreted as a degree of plasma membrane damage since decrease in transmembrane potential accompanies disruption of the cell membrane.

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PMC11767793

The control choice is also related to the assay endpoint and the exposure route.

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PMC11799978

Therefore, targeting CAFs in cancer therapy demands new strategies.

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PMC11732635

Our case report supports CAR T-cell therapy as a relatively safe and effective treatment for CAEBV in children, with milder CRS compared to that observed in malignant tumors.

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PMC10079526

Only pathways significantly enriched and with a fold enrichment of more than 20 are shown.

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PMC9429973

The patients received the first line chemotherapy according to the national MDH 2015 protocol.

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PMC9429973

In the HFE gene analysis, the H63D mutation was found to be heterozygous.

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PMC11733919

Interestingly, we showed that MNPs could be degraded in a lysosomal medium but not in water.

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PMC11742290

Table 1Summary of the functional roles of LGR5 in cancersFunctional rolesTumor TypeCell lines/Animal speciesRefProliferation and Apoptosis Transfection with LGR5-specific siRNA decreased proliferation capacity of primary astrocytesBrainAdult male Sprague–Dawley rats (n = 72): sham operation (n = 12) and contusion injury (n = 60) LGR5 silencing in U87 cells suppressed cell proliferation and cell cycle and reduced tumor-sphere formation in vitro LGR5 depletion significantly inhibited tumor orthotropic xenograft growth in vivoBrainU87 cell lineBALB/C nude mice Silencing of LGR5 by lentiviral shRNA-mediated knockdown induced apoptosis in brain CSCsBrainBrain CSC lines NCH421k and NCH441 cells LGR5 mRNA and protein activate the WNT/β-catenin signaling pathway and enhance cell proliferation by activating PKABreastBreast cancer cell line: MCF-7 LGR5 siRNA inhibited cell proliferation with induced apoptosis via suppressing the WNT/β-catenin signaling pathwayBreastBreast cancer cell lines: MCF-7, MDA-MB-231, BT-549, ZR-75–1 LGR5-KD reduced cancer clonogenicity and tumorigenesisBreastBreast cancer cell lines: MDA-ctrl and MDA-LGR5KD LGR5 does not promote Ewing sarcoma (ES) cell proliferation in vitroEwing sarcoma Bone cancer cell lines: A673 and CHLA25 Elevated LGR5 expression increased tumor sphere-forming efficiency in vitro.

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PMC9429973

There were 34.21% (13/38) of patients with Ph(+), 34.21% (13/38) with extramedullary disease (EMD), 10.52% (4/38) with MLL-AF4 fusion gene (+), and 5.26% (2/38) had received HSCT prior to CAR-T therapy.

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PMC9429973

TFR1 and FTL mRNA levels were assessed at 8h, 16h, 24h, 48h.

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PMC11551844

Aurimune (CYT-6091) (PEGylated) (27 nm) has completed phase I for the treatment of patients with advanced solid tumors and phase II clinical trial agreement with the National Cancer Institute (NCI) has been signed.

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PMC11552389

On day 24 post-transplantation, tumor samples were taken and weighed. (

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PMC11024707

One of the strengths is that it is one of the rare studies in the literature that compares siblings of patients with ASD with the normal group and examines the association of mi-RNAs investigated in ASD with additional problems besides the core autism symptoms, and to the best of our knowledge, it is the first study to examine the association of mi-RNAs with autistic traits.

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PMC10329237

The effect of different concentrations of (A) BLM (0.05–0.5 µg/ml), (B) LOS (0.05–1 mM), and (C) PFD (0.025–0.5 mM) on % of cell growth of A549 cell line after 48 hr post-treatment.

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PMC5308810

On the other hand, a small percentage (4%) of the pure CXCR4 population transit to CXCR4 over time.

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PMC10577955

In a 96-well tissue culture plate, all cell lines were planted at a density of 1 × 10 cells per ml (100 µl per well), and they were then allowed to grow for 24 h at 37 °C to produce a full monolayer sheet.

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PMC9429973

One patient eligible for second-line treatment refused further therapeutic measures.

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PMC11593084

In mAb therapy for solid tumors, trastuzumab and pertuzumab were approved by the FDA for human epidermal growth factor receptor 2 (HER2)-overexpressed breast cancer in 1998 and 2012, respectively .

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PMC11657695

Among all these channels, the voltage-dependent potassium channels (Kv) compose one of the largest subfamilies, with over 20 channels .

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PMC11720107

In normal cells, ROS have numerous physiological and pathological functions.

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PMC11388384

We used ExTrack to jointly estimate the diffusion rate of each population, the occupancy of each population, and transition rate between each population under the assumption that transitions occur at most once per 6 ms observation interval.

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PMC11361748

Genes significantly up-regulated after dual TPA Tx compared to dual acetone-Tx, 24 h apart, in WT and Krt17 mouse skin (Cutoffs: FDR-adjusted P < 0.01, fold change > 8). (

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PMC11772585

B The samples highlighted in red in A were magnified.

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PMC10656496

With faster growth in optimized conditions, we considered the 143B cell line to be akin to the dominant population initially present at diagnosis and often more sensitive to chemotherapy which aligns with reported in vivo data.

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PMC10654497

Heatmap showing the expression relationship of the top 40 differential genes between the C1 and C2 subtypes. (

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PMC9429973

Four selected drugs are under evaluation in AML-PDX models.

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PMC9503685

Encapsulation of CSA-131 in poloxamer micelles decreases cytotoxicity and increases cell membrane selectivity.

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PMC11496728

The results indicated that the abovementioned three monoclonal strains were successfully knocked out.

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PMC8389560

The solid target was placed at the bottom of a cuvette under a thin layer of water.

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PMC9429973

Results: EZH2i led to a drastic increase in Oxaliplatin resistance in all tested cell lines regardless of cell type or EZH2 and H3K27 methylation status.

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PMC6222635

The signal at δ4.43 represents the anomer hydrogen of (1→4)-linked glucose.

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PMC9429973

Three patients with moderate PH at baseline developed variceal bleeding (2) and ascites (1).

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PMC11633763

Additionally, USP22 knockdown decreased the proliferation and glycolytic rate of the osteosarcoma cell line 143B.

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PMC9429973

Twenty patients (62.9%) had genetically confirmed HLH; Twelve (34.3%) of them had MUNC13D mutations, Three (8.6%) had STXBP2 mutation, Five (14.3%) had RAB27A mutation while four (11.4%) had secondary HLH.

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PMC11240448

Thus, being activated by EGFR-PI3K signaling, the mTOR-PKC pair self-amplifies its signaling, generating sustained activating signals for oncogenic transformation.

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PMC11682172

The lowest and highest boundaries of the box represent the 25 and 75 percentiles, respectively.

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PMC11089031

Renal cell carcinoma (RCC) is essentially a metabolic disease characterized by a reprogramming of energetic metabolism [26–29].

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PMC10932641

When the cell density reached about 70–80%, the cells were subcultured according at a 1:3 ratio, and counting was performed after continuous culture for three generations.

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PMC11240052

Non-viable necrotic cells, upper left (Q1), late apoptotic cells, top right (Q2), early apoptotic cells, bottom right (Q3), viable cells lower left (Q4).

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PMC7582629

The histochemical staining technique is the standard method for analyzing the cellular morphology such as size, shape and granularity, however, it suffers from some limitations and is not able to provide reliable information on the biochemical changes in or the specific immunophenotype of cells.

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