OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11519583	c MPs, transfected with the indicated siRNAs, followed by treatment with cytochalasin D, were stained with an anti-lamin B1 antibody (magenta) and DAPI (cyan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "MPs", ",", "transfected", "with", "the", "indicated", "siRNAs", ",", "followed", "by", "treatment", "with", "cytochalasin", "D", ",", "were", "stained", "with", "an", "anti-lamin", "B1", "antibody", "(", "magenta", ")", "and", "DAPI", "(", "cyan", ")", "." ] } ]
PMC11347429	The respective raw and normalized data are available at the GEO (GEO) public database (see Table 1 for availability of supplementary data and tables).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "respective", "raw", "and", "normalized", "data", "are", "available", "at", "the", "GEO", "(", "GEO", ")", "public", "database", "(", "see", "Table", "1", "for", "availability", "of", "supplementary", "data", "and", "tables", ")", "." ] } ]
PMC11087766	Mapping the nonconserved amino acids in this region to the AlphaFold-predicted structure (35) of PhiKZ gp104 shows that they are part of an exposed surface of the protein that we call the recognition region (Fig. 1E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mapping", "the", "nonconserved", "amino", "acids", "in", "this", "region", "to", "the", "AlphaFold-predicted", "structure", "(", "35", ")", "of", "PhiKZ", "gp104", "shows", "that", "they", "are", "part", "of", "an", "exposed", "surface", "of", "the", "protein", "that", "we", "call", "the", "recognition", "region", "(", "Fig.", "1E", ")", "." ] } ]
PMC10887351	Indeed, β3-AR antagonism on tumor-infiltrating lymphocytes (TILs) reduced their ability to produce IFN-γ, which reduced the expression of PD-L1 provoked by TILs infiltration into NB tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed", ",", "β3-AR", "antagonism", "on", "tumor-infiltrating", "lymphocytes", "(", "TILs", ")", "reduced", "their", "ability", "to", "produce", "IFN-γ", ",", "which", "reduced", "the", "expression", "of", "PD-L1", "provoked", "by", "TILs", "infiltration", "into", "NB", "tumor", "cells", "." ] } ]
PMC11721064	Inhibition of STAT3 blocked the activation of PI3K/AKT signaling pathway and impaired corneal epithelial cell transdifferentiation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inhibition", "of", "STAT3", "blocked", "the", "activation", "of", "PI3K/AKT", "signaling", "pathway", "and", "impaired", "corneal", "epithelial", "cell", "transdifferentiation", "." ] } ]
PMC7215722	E.E. Sterchi and H.-P. Hauri, formerly at the University of Bern and University of Basel, Switzerland, and Dr. B. Nichols, Baylor College of Medicine, Houston, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E.E.", "Sterchi", "and", "H.-P.", "Hauri", ",", "formerly", "at", "the", "University", "of", "Bern", "and", "University", "of", "Basel", ",", "Switzerland", ",", "and", "Dr.", "B.", "Nichols", ",", "Baylor", "College", "of", "Medicine", ",", "Houston", ",", "USA", ")", "." ] } ]
PMC11476106	Increased VN secretion has been associated with the bodily response to tissue damage or inflammation in studies with hepatic tissues, indicating that cells are trying to survive .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Increased", "VN", "secretion", "has", "been", "associated", "with", "the", "bodily", "response", "to", "tissue", "damage", "or", "inflammation", "in", "studies", "with", "hepatic", "tissues", ",", "indicating", "that", "cells", "are", "trying", "to", "survive", "." ] } ]
PMC11300639	e–k 786-O and A498 cells were infected with indicated shRNAs for 72 h. Then, these cells were treated with or without Everolimus and subjected to western blotting, transwell, CCK-8, tube formation, and nude mouse xenografts assay.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "e", "–", "k", "786-O", "and", "A498", "cells", "were", "infected", "with", "indicated", "shRNAs", "for", "72", "h.", "Then", ",", "these", "cells", "were", "treated", "with", "or", "without", "Everolimus", "and", "subjected", "to", "western", "blotting", ",", "transwell", ",", "CCK-8", ",", "tube", "formation", ",", "and", "nude", "mouse", "xenografts", "assay", "." ] } ]
PMC11574271	The identification of the hsa-miR-659-3p/RON and RON/JNK/HIF-2α/MMP12 pathways offer valuable insights into the pathogenesis of bladder cancer and may serve as potential targets for therapeutic interventions in the management of this disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "identification", "of", "the", "hsa-miR-659", "-", "3p/RON", "and", "RON/JNK/HIF-2α/MMP12", "pathways", "offer", "valuable", "insights", "into", "the", "pathogenesis", "of", "bladder", "cancer", "and", "may", "serve", "as", "potential", "targets", "for", "therapeutic", "interventions", "in", "the", "management", "of", "this", "disease", "." ] } ]
PMC4005030	Protocatechuic acid (PCA) is widely distributed and present in most edible plants used in folk medicine .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protocatechuic", "acid", "(", "PCA", ")", "is", "widely", "distributed", "and", "present", "in", "most", "edible", "plants", "used", "in", "folk", "medicine", "." ] } ]
PMC9046263	RNA was isolated from NHA, A172, GBM28, and GBM43 using Trizol extraction with chloroform as previously described.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "was", "isolated", "from", "NHA", ",", "A172", ",", "GBM28", ",", "and", "GBM43", "using", "Trizol", "extraction", "with", "chloroform", "as", "previously", "described", "." ] } ]
PMC9429973	A 3 vaccine dose to complete primary vaccination has since been recommended.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "3", "vaccine", "dose", "to", "complete", "primary", "vaccination", "has", "since", "been", "recommended", "." ] } ]
PMC8427838	786-0 cells expressing TMIGD1 alone or with other constructs were stained for actin, as described above, and visualized using an inverted epifluorescence microscope.	[ { "tags": [ "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "786", "-", "0", "cells", "expressing", "TMIGD1", "alone", "or", "with", "other", "constructs", "were", "stained", "for", "actin", ",", "as", "described", "above", ",", "and", "visualized", "using", "an", "inverted", "epifluorescence", "microscope", "." ] } ]
PMC10297204	Therefore, this study proved that ethanol adjuvant therapy with 30% concentration has anti-tumor effects after surgery for STS with a close margin to the sciatic nerve without increasing the risk of neurotoxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "this", "study", "proved", "that", "ethanol", "adjuvant", "therapy", "with", "30", "%", "concentration", "has", "anti-tumor", "effects", "after", "surgery", "for", "STS", "with", "a", "close", "margin", "to", "the", "sciatic", "nerve", "without", "increasing", "the", "risk", "of", "neurotoxicity", "." ] } ]
PMC10452486	Furthermore, several reports have emerged postulating independent surface expression of Face-2, without dissociating from Face-1 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "several", "reports", "have", "emerged", "postulating", "independent", "surface", "expression", "of", "Face-2", ",", "without", "dissociating", "from", "Face-1", "." ] } ]
PMC6222726	Their leaves are imparipinnate, sometimes bipinnate, up to 30 cm long and 18 cm wide, with 7 to 11 leaflets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Their", "leaves", "are", "imparipinnate", ",", "sometimes", "bipinnate", ",", "up", "to", "30", "cm", "long", "and", "18", "cm", "wide", ",", "with", "7", "to", "11", "leaflets", "." ] } ]
PMC10933092	Kaplan-Meier analysis examines the prognostic value of the four transcripts according to their median expression levels in BLCA tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kaplan-Meier", "analysis", "examines", "the", "prognostic", "value", "of", "the", "four", "transcripts", "according", "to", "their", "median", "expression", "levels", "in", "BLCA", "tissues", "." ] } ]
PMC9429973	Therefore, there is a need for a modified conditioning regimen that can enhance anti-leukemic effects in aggressive diseases such as acute leukemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "there", "is", "a", "need", "for", "a", "modified", "conditioning", "regimen", "that", "can", "enhance", "anti-leukemic", "effects", "in", "aggressive", "diseases", "such", "as", "acute", "leukemia", "." ] } ]
PMC11180402	A Relative SOX2 mRNA levels in 5637 cells treated with 20 μM ISO at indicated times by RT-qPCR. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Relative", "SOX2", "mRNA", "levels", "in", "5637", "cells", "treated", "with", "20", "μM", "ISO", "at", "indicated", "times", "by", "RT-qPCR", ".", "(" ] } ]
PMC11534035	At 1 μM, an average of 45.67±38.69 colonies were formed (p<0.005).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "1", "μM", ",", "an", "average", "of", "45.67±38.69", "colonies", "were", "formed", "(", "p<0.005", ")", "." ] } ]
PMC11806818	The preparation process of Apt/Fe-N-C SAzymes and the principle of colorimetric detection of cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "preparation", "process", "of", "Apt/Fe-N-C", "SAzymes", "and", "the", "principle", "of", "colorimetric", "detection", "of", "cancer", "cells", "." ] } ]
PMC11741906	The expression levels were normalized to SNORD95 and relative to A2780 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "expression", "levels", "were", "normalized", "to", "SNORD95", "and", "relative", "to", "A2780", "cells", "." ] } ]
PMC11632064	Rho-0 cells still possess mitochondria, but they are part of fragmented networks and show no respiratory activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rho-0", "cells", "still", "possess", "mitochondria", ",", "but", "they", "are", "part", "of", "fragmented", "networks", "and", "show", "no", "respiratory", "activity", "." ] } ]
PMC11295144	Cultured cells were lysed with 2% SDS and the protein concentration determined using the BCA assay (Thermo Fisher Scientifics).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cultured", "cells", "were", "lysed", "with", "2", "%", "SDS", "and", "the", "protein", "concentration", "determined", "using", "the", "BCA", "assay", "(", "Thermo", "Fisher", "Scientifics", ")", "." ] } ]
PMC6461034	Transfer the supernatant from the previous spin (peptide solution) to an “IP” tube with 20 μl aliquoted antibody‐conjugated beads, pipetting directly on top of the beads (without touching).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transfer", "the", "supernatant", "from", "the", "previous", "spin", "(", "peptide", "solution", ")", "to", "an", "“", "IP", "”", "tube", "with", "20", "μl", "aliquoted", "antibody‐conjugated", "beads", ",", "pipetting", "directly", "on", "top", "of", "the", "beads", "(", "without", "touching", ")", "." ] } ]
PMC7840816	Some reports demonstrated that SOX9 was overexpressed in gastric carcinoma, breast cancer, pancreatic ductal adenocarcinoma, and glioma (9–12), whereas other studies showed that SOX9 may function as a tumor suppressor, such as in bladder cancer and melanoma (13,14).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "reports", "demonstrated", "that", "SOX9", "was", "overexpressed", "in", "gastric", "carcinoma", ",", "breast", "cancer", ",", "pancreatic", "ductal", "adenocarcinoma", ",", "and", "glioma", "(", "9–12", ")", ",", "whereas", "other", "studies", "showed", "that", "SOX9", "may", "function", "as", "a", "tumor", "suppressor", ",", "such", "as", "in", "bladder", "cancer", "and", "melanoma", "(", "13,14", ")", "." ] } ]
PMC10914904	During inflammation-associated cancer, the binding of NF-κB to gene promoters induces the expression of cytokines such as TNF-α, IL-1B, and IL-6, thereby facilitating cell proliferation, invasion, angiogenesis, and macrophage polarization in several tumors [156–158].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "inflammation-associated", "cancer", ",", "the", "binding", "of", "NF-κB", "to", "gene", "promoters", "induces", "the", "expression", "of", "cytokines", "such", "as", "TNF-α", ",", "IL-1B", ",", "and", "IL-6", ",", "thereby", "facilitating", "cell", "proliferation", ",", "invasion", ",", "angiogenesis", ",", "and", "macrophage", "polarization", "in", "several", "tumors", "[", "156–158", "]", "." ] } ]
PMC11467964	The K–M curve revealed that STS patients had a markedly better OS in low‐risk group (p < .05, Figure 5E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "K", "–", "M", "curve", "revealed", "that", "STS", "patients", "had", "a", "markedly", "better", "OS", "in", "low‐risk", "group", "(", "p", "<", ".05", ",", "Figure", "5E", ")", "." ] } ]
PMC8526701	Furthermore, the pharmacological inhibition of BRD9 with the help of a small molecular inhibitor, GSK602, exerts a significant antitumorigenic effect in different types of cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", "pharmacological", "inhibition", "of", "BRD9", "with", "the", "help", "of", "a", "small", "molecular", "inhibitor", ",", "GSK602", ",", "exerts", "a", "significant", "antitumorigenic", "effect", "in", "different", "types", "of", "cancers", "." ] } ]
PMC11351758	Cytochrome C release from the mitochondria is the ultimate effect of peroxidized CL on mitochondria .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytochrome", "C", "release", "from", "the", "mitochondria", "is", "the", "ultimate", "effect", "of", "peroxidized", "CL", "on", "mitochondria", "." ] } ]
PMC9611901	The increased levels of primary DNA damage measured in these cells were apparently due to complex interactions between highly reactive compounds of natural origin that were efficiently released into the cell medium due to their high solubility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "increased", "levels", "of", "primary", "DNA", "damage", "measured", "in", "these", "cells", "were", "apparently", "due", "to", "complex", "interactions", "between", "highly", "reactive", "compounds", "of", "natural", "origin", "that", "were", "efficiently", "released", "into", "the", "cell", "medium", "due", "to", "their", "high", "solubility", "." ] } ]
PMC6190245	F. gummosa also exhibited a significant anti-proliferation and apoptosis-inducing effect on gastric cancer (Gharaei et al., 2011 ▶).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F.", "gummosa", "also", "exhibited", "a", "significant", "anti-proliferation", "and", "apoptosis-inducing", "effect", "on", "gastric", "cancer", "(", "Gharaei", "et", "al.", ",", "2011", "▶", ")", "." ] } ]
PMC11366496	The tissues and cells underwent lysis and were quantified using RIPA buffer and bicinchoninic acid (BCA) (Servicebio, Wuhan, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "tissues", "and", "cells", "underwent", "lysis", "and", "were", "quantified", "using", "RIPA", "buffer", "and", "bicinchoninic", "acid", "(", "BCA", ")", "(", "Servicebio", ",", "Wuhan", ",", "China", ")", "." ] } ]
PMC11549062	In our study, we found that increased PTP1B expression leads to apoptosis, suppresses carotid VSMCs migration and proliferation, and promotes the vulnerability of carotid plaque.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "our", "study", ",", "we", "found", "that", "increased", "PTP1B", "expression", "leads", "to", "apoptosis", ",", "suppresses", "carotid", "VSMCs", "migration", "and", "proliferation", ",", "and", "promotes", "the", "vulnerability", "of", "carotid", "plaque", "." ] } ]
PMC11731614	Nevertheless, this study enhances our understanding of the communication between keratinocytes and DRG neurons via KDEVs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nevertheless", ",", "this", "study", "enhances", "our", "understanding", "of", "the", "communication", "between", "keratinocytes", "and", "DRG", "neurons", "via", "KDEVs", "." ] } ]
PMC6160470	As expected, A2780/Adr cells showed cross-resistant phenotype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "expected", ",", "A2780/Adr", "cells", "showed", "cross-resistant", "phenotype", "." ] } ]
PMC11753435	Raw, uncropped blots are shown in fig. S4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Raw", ",", "uncropped", "blots", "are", "shown", "in", "fig.", "S4", "." ] } ]
PMC11467800	The white arrows indicate a new vessel formation near the SIV. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "white", "arrows", "indicate", "a", "new", "vessel", "formation", "near", "the", "SIV", ".", "(" ] } ]
PMC11774747	Several explanations have been proposed, including a lower avidity of VST TCR for the allogeneic epitope compared to the viral epitope, and the role of immunosuppressive regimens in transplanted patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "explanations", "have", "been", "proposed", ",", "including", "a", "lower", "avidity", "of", "VST", "TCR", "for", "the", "allogeneic", "epitope", "compared", "to", "the", "viral", "epitope", ",", "and", "the", "role", "of", "immunosuppressive", "regimens", "in", "transplanted", "patients", "." ] } ]
PMC10955424	Our findings, as shown in Fig. 1, demonstrated that the preponderance of malignant ascites—more than 85 %—were active in conferring platinum chemoresistance to OC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "findings", ",", "as", "shown", "in", "Fig.", "1", ",", "demonstrated", "that", "the", "preponderance", "of", "malignant", "ascites", "—", "more", "than", "85", "%", "—were", "active", "in", "conferring", "platinum", "chemoresistance", "to", "OC", "cells", "." ] } ]
PMC11547972	Rather, cell signaling was differentially modulated, depending on the cell line and applied drug.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rather", ",", "cell", "signaling", "was", "differentially", "modulated", ",", "depending", "on", "the", "cell", "line", "and", "applied", "drug", "." ] } ]
PMC10440586	The next three tracks indicate the P value of three transcriptional subtypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "next", "three", "tracks", "indicate", "the", "P", "value", "of", "three", "transcriptional", "subtypes", "." ] } ]
PMC11190238	Within CTs, there are chromatin compartments, comprising A compartments with open euchromatin enriched in highly expressed genes, and B compartments with closed heterochromatin associated with repressed transcription regions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Within", "CTs", ",", "there", "are", "chromatin", "compartments", ",", "comprising", "A", "compartments", "with", "open", "euchromatin", "enriched", "in", "highly", "expressed", "genes", ",", "and", "B", "compartments", "with", "closed", "heterochromatin", "associated", "with", "repressed", "transcription", "regions", "." ] } ]
PMC11265931	Our findings support the idea that SEVs produced from garlic may trigger apoptotic cell death in cancer cells while having no effect on healthy cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "findings", "support", "the", "idea", "that", "SEVs", "produced", "from", "garlic", "may", "trigger", "apoptotic", "cell", "death", "in", "cancer", "cells", "while", "having", "no", "effect", "on", "healthy", "cells", "." ] } ]
PMC11676674	In this work, the metabolite composition of methanolic extracts obtained from C. monspeliensis leaves was evaluated using an untargeted metabolomic approach by UPLC analysis coupled to High Resolution Mass Spectrometry (HRMS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "work", ",", "the", "metabolite", "composition", "of", "methanolic", "extracts", "obtained", "from", "C.", "monspeliensis", "leaves", "was", "evaluated", "using", "an", "untargeted", "metabolomic", "approach", "by", "UPLC", "analysis", "coupled", "to", "High", "Resolution", "Mass", "Spectrometry", "(", "HRMS", ")", "." ] } ]
PMC11144382	We used MEFs derived from wild-type (WT; Nfix) mice, and previously established Nfix, Nfix, Nfix, Nfix, Nfix and Nfix mutant mice that had deletions in exon 7 comprising: a 140 nucleotide deletion (Del140) that caused skipping of exon 7 due to alternative splicing of exon 6 to exon 8 and production of wild-type short Nfix isoforms that lack exon 7; an in-frame 24 nucleotide deletion (Del24) which caused loss of 8 amino acids; and a 2 nucleotide deletion (Del2) that caused a frame shift and a premature termination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "MEFs", "derived", "from", "wild-type", "(", "WT", ";", "Nfix", ")", "mice", ",", "and", "previously", "established", "Nfix", ",", "Nfix", ",", "Nfix", ",", "Nfix", ",", "Nfix", "and", "Nfix", "mutant", "mice", "that", "had", "deletions", "in", "exon", "7", "comprising", ":", "a", "140", "nucleotide", "deletion", "(", "Del140", ")", "that", "caused", "skipping", "of", "exon", "7", "due", "to", "alternative", "splicing", "of", "exon", "6", "to", "exon", "8", "and", "production", "of", "wild-type", "short", "Nfix", "isoforms", "that", "lack", "exon", "7", ";", "an", "in-frame", "24", "nucleotide", "deletion", "(", "Del24", ")", "which", "caused", "loss", "of", "8", "amino", "acids", ";", "and", "a", "2", "nucleotide", "deletion", "(", "Del2", ")", "that", "caused", "a", "frame", "shift", "and", "a", "premature", "termination", "." ] } ]
PMC11469524	We performed a profile likelihood analysis that unveiled that about half of the non-inhibitor coefficient (path)s (11 of 21, asterisks Fig 2E) are significantly different, i.e., the 95% pointwise confidence intervals do not overlap.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "performed", "a", "profile", "likelihood", "analysis", "that", "unveiled", "that", "about", "half", "of", "the", "non-inhibitor", "coefficient", "(path)s", "(", "11", "of", "21", ",", "asterisks", "Fig", "2E", ")", "are", "significantly", "different", ",", "i.e.", ",", "the", "95", "%", "pointwise", "confidence", "intervals", "do", "not", "overlap", "." ] } ]
PMC11592837	Nonetheless, a combined monitoring of both markers in future clinical studies with patient material should prove a superior diagnostic outcome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nonetheless", ",", "a", "combined", "monitoring", "of", "both", "markers", "in", "future", "clinical", "studies", "with", "patient", "material", "should", "prove", "a", "superior", "diagnostic", "outcome", "." ] } ]
PMC11011837	Heatmap visualization was applied on the lipidomic data matrix to study the quantitative differences among the single lipids inside the different cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Heatmap", "visualization", "was", "applied", "on", "the", "lipidomic", "data", "matrix", "to", "study", "the", "quantitative", "differences", "among", "the", "single", "lipids", "inside", "the", "different", "cell", "lines", "." ] } ]
PMC9096373	Calculation of apoptosis was similar to those with VEGFR-2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Calculation", "of", "apoptosis", "was", "similar", "to", "those", "with", "VEGFR-2", "." ] } ]
PMC6835428	The ideal cellular model should be able to replicate the main phenotypic and genetic characteristics of OC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ideal", "cellular", "model", "should", "be", "able", "to", "replicate", "the", "main", "phenotypic", "and", "genetic", "characteristics", "of", "OC", "cells", "." ] } ]
PMC11138140	As expected, the norepinephrine-treated cardiomyocytes exhibited significant spreading and formed cellular protrusions by the end of the 24 h treatment relative to the untreated controls (Figure 1C), which is consistent with previous observations .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "expected", ",", "the", "norepinephrine-treated", "cardiomyocytes", "exhibited", "significant", "spreading", "and", "formed", "cellular", "protrusions", "by", "the", "end", "of", "the", "24", "h", "treatment", "relative", "to", "the", "untreated", "controls", "(", "Figure", "1C", ")", ",", "which", "is", "consistent", "with", "previous", "observations", "." ] } ]
PMC11755624	Stimulated keratinocytes release immunoregulatory mediators such as IL-19 and IL-36 (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Stimulated", "keratinocytes", "release", "immunoregulatory", "mediators", "such", "as", "IL-19", "and", "IL-36", "(", "Figure", "1", ")", "." ] } ]
PMC9065483	We found that upon stimulation using IFNβ, vanadate treatment led to concentrated nuclear localization of phosphorylated STAT1 compared with cells only treated with IFNβ, where nuclear phospho-STAT1 signal was more diffuse (Figures 3D and S11).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "found", "that", "upon", "stimulation", "using", "IFNβ", ",", "vanadate", "treatment", "led", "to", "concentrated", "nuclear", "localization", "of", "phosphorylated", "STAT1", "compared", "with", "cells", "only", "treated", "with", "IFNβ", ",", "where", "nuclear", "phospho-STAT1", "signal", "was", "more", "diffuse", "(", "Figures", "3D", "and", "S11", ")", "." ] } ]
PMC11758416	Discard supernatant from staining plate or FACS tubes and begin staining steps.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Discard", "supernatant", "from", "staining", "plate", "or", "FACS", "tubes", "and", "begin", "staining", "steps", "." ] } ]
PMC9424261	HERPUD1 is an endoplasmic reticulum (ER) membrane protein that is generally expressed and highly induced during unfolded protein responses (UPR) and cell stress .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HERPUD1", "is", "an", "endoplasmic", "reticulum", "(", "ER", ")", "membrane", "protein", "that", "is", "generally", "expressed", "and", "highly", "induced", "during", "unfolded", "protein", "responses", "(", "UPR", ")", "and", "cell", "stress", "." ] } ]
PMC11087055	If the bilateral rotating cell flow is required for PS formation, both the authentic and induced PSs should each be accompanied by polonaise movements during the extension.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "If", "the", "bilateral", "rotating", "cell", "flow", "is", "required", "for", "PS", "formation", ",", "both", "the", "authentic", "and", "induced", "PSs", "should", "each", "be", "accompanied", "by", "polonaise", "movements", "during", "the", "extension", "." ] } ]
PMC9111184	The obtained results showed that even with a diet rich in cholesterol, hydroxycinnamic acid derivatives and EZ have a high permeability and allow them to enter the blood stream and reach other organs such as the liver where they showed an effect cholesterol biosynthesis inhibition through the inhibition of the enzyme HMGR and the regulation of cholesterol transporter proteins responsible of cholesterol excretion (Arantes et al., 2016; Guedes et al., 2019; Ressaissi et al., 2017, 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "obtained", "results", "showed", "that", "even", "with", "a", "diet", "rich", "in", "cholesterol", ",", "hydroxycinnamic", "acid", "derivatives", "and", "EZ", "have", "a", "high", "permeability", "and", "allow", "them", "to", "enter", "the", "blood", "stream", "and", "reach", "other", "organs", "such", "as", "the", "liver", "where", "they", "showed", "an", "effect", "cholesterol", "biosynthesis", "inhibition", "through", "the", "inhibition", "of", "the", "enzyme", "HMGR", "and", "the", "regulation", "of", "cholesterol", "transporter", "proteins", "responsible", "of", "cholesterol", "excretion", "(", "Arantes", "et", "al.", ",", "2016", ";", "Guedes", "et", "al.", ",", "2019", ";", "Ressaissi", "et", "al.", ",", "2017", ",", "2020", ")", "." ] } ]
PMC11244823	At least two previous studies have shown that the receptor-binding protein, glycoprotein D (gD), drastically affects if not determines both the host range and the clinical severity of EHV-infections .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "least", "two", "previous", "studies", "have", "shown", "that", "the", "receptor-binding", "protein", ",", "glycoprotein", "D", "(", "gD", ")", ",", "drastically", "affects", "if", "not", "determines", "both", "the", "host", "range", "and", "the", "clinical", "severity", "of", "EHV-infections", "." ] } ]
PMC11737091	After activation by the DBF4 subunit, CDC7 directly phosphorylates the MCM 2–7 complex .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "activation", "by", "the", "DBF4", "subunit", ",", "CDC7", "directly", "phosphorylates", "the", "MCM", "2–7", "complex", "." ] } ]
PMC11802855	After CD138 magnetic bead sorting, we performed high-throughput transcriptome sequencing, identifying 52 differentially expressed genes (\|logFC \| > 1, FDR < 0.01) (via DESeq2) (Fig. 1A).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "CD138", "magnetic", "bead", "sorting", ",", "we", "performed", "high-throughput", "transcriptome", "sequencing", ",", "identifying", "52", "differentially", "expressed", "genes", "(", "\|logFC", "\|", ">", "1", ",", "FDR", "<", "0.01", ")", "(", "via", "DESeq2", ")", "(", "Fig.", "1A).Fig", "." ] } ]
PMC11790971	Advancements in ML techniques have greatly enhanced the feasibility and popularity of high-content single-cell profiling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Advancements", "in", "ML", "techniques", "have", "greatly", "enhanced", "the", "feasibility", "and", "popularity", "of", "high-content", "single-cell", "profiling", "." ] } ]
PMC11023271	LPA also exists in many isoforms .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LPA", "also", "exists", "in", "many", "isoforms", "." ] } ]
PMC10729469	B, F Data presented as mean ± SEM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ",", "F", "Data", "presented", "as", "mean", "±", "SEM", "." ] } ]
PMC9429973	These survival measures were presented by year of diagnosis for four ages at diagnosis (i.e., 40, 50, 60, and 70 years), stratified by sex.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "survival", "measures", "were", "presented", "by", "year", "of", "diagnosis", "for", "four", "ages", "at", "diagnosis", "(", "i.e.", ",", "40", ",", "50", ",", "60", ",", "and", "70", "years", ")", ",", "stratified", "by", "sex", "." ] } ]
PMC9429973	All patients received LD before infusion, fludarabine/bendamustine in HL patients (n=8) and fludarabine/cyclophosphamide in T-NHL (n=2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "patients", "received", "LD", "before", "infusion", ",", "fludarabine/bendamustine", "in", "HL", "patients", "(", "n=8", ")", "and", "fludarabine/cyclophosphamide", "in", "T-NHL", "(", "n=2", ")", "." ] } ]
PMC9429973	In 21 patients from Iven group, with a median follow-up of 7.4 months, a complete remission was achieved (72.4%); of these, 8 had unmeasurable MRD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "21", "patients", "from", "Iven", "group", ",", "with", "a", "median", "follow-up", "of", "7.4", "months", ",", "a", "complete", "remission", "was", "achieved", "(", "72.4", "%", ")", ";", "of", "these", ",", "8", "had", "unmeasurable", "MRD", "." ] } ]
PMC11529598	p < 0.05.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", "." ] } ]
PMC11675244	For instance, Wnt-5a, commonly involved in neural crest cell migration, decreases its expression once cells reach their destination tissue .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "instance", ",", "Wnt-5a", ",", "commonly", "involved", "in", "neural", "crest", "cell", "migration", ",", "decreases", "its", "expression", "once", "cells", "reach", "their", "destination", "tissue", "." ] } ]
PMC11740907	The versatile nature of beeswax, acting as a lipid matrix, facilitates the encapsulation of hydrophobic medicines, hence playing a crucial role in the creation of effective and secure drug delivery systems.19 Furthermore, its sustainable and renewable characteristics are in line with the increasing focus on green formulations in the field of pharmaceuticals.20 The process entails constructing three-dimensional structures of the molecules, optimizing energy, and producing numerous binding positions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "versatile", "nature", "of", "beeswax", ",", "acting", "as", "a", "lipid", "matrix", ",", "facilitates", "the", "encapsulation", "of", "hydrophobic", "medicines", ",", "hence", "playing", "a", "crucial", "role", "in", "the", "creation", "of", "effective", "and", "secure", "drug", "delivery", "systems.19", "Furthermore", ",", "its", "sustainable", "and", "renewable", "characteristics", "are", "in", "line", "with", "the", "increasing", "focus", "on", "green", "formulations", "in", "the", "field", "of", "pharmaceuticals.20", "The", "process", "entails", "constructing", "three-dimensional", "structures", "of", "the", "molecules", ",", "optimizing", "energy", ",", "and", "producing", "numerous", "binding", "positions", "." ] } ]
PMC11637276	Therefore, to prevent lysosomal degradation and discern between changes that could be due to altered ECM degradation rather than endocytosis, cells were treated with a cysteine-cathepsin lysosomal inhibitor, E64d .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "to", "prevent", "lysosomal", "degradation", "and", "discern", "between", "changes", "that", "could", "be", "due", "to", "altered", "ECM", "degradation", "rather", "than", "endocytosis", ",", "cells", "were", "treated", "with", "a", "cysteine-cathepsin", "lysosomal", "inhibitor", ",", "E64d", "." ] } ]
PMC11548041	Aptamer-based therapies have several advantages over conventional monoclonal antibody therapies such as superior solid tumor penetration and amenability to engineering.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aptamer-based", "therapies", "have", "several", "advantages", "over", "conventional", "monoclonal", "antibody", "therapies", "such", "as", "superior", "solid", "tumor", "penetration", "and", "amenability", "to", "engineering", "." ] } ]
PMC7840816	Knockdown of SOX9 inhibited cell growth and invasion by suppressing the Wnt/β-catenin signaling in PTC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Knockdown", "of", "SOX9", "inhibited", "cell", "growth", "and", "invasion", "by", "suppressing", "the", "Wnt/β-catenin", "signaling", "in", "PTC", "cells", "." ] } ]
PMC11757230	Animals were handled in accordance with the animal care guidelines of the Institute of Laboratory Animal Resources of Nippon Veterinary and Life Science University, which conform to national guidelines, and international guidelines such as the ARRIVE guidelines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Animals", "were", "handled", "in", "accordance", "with", "the", "animal", "care", "guidelines", "of", "the", "Institute", "of", "Laboratory", "Animal", "Resources", "of", "Nippon", "Veterinary", "and", "Life", "Science", "University", ",", "which", "conform", "to", "national", "guidelines", ",", "and", "international", "guidelines", "such", "as", "the", "ARRIVE", "guidelines", "." ] } ]
PMC6901583	This process involves angiogenic factors, such as bFGF, PDGFB, and VEGF secreted by the cells of the tumor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "process", "involves", "angiogenic", "factors", ",", "such", "as", "bFGF", ",", "PDGFB", ",", "and", "VEGF", "secreted", "by", "the", "cells", "of", "the", "tumor", "." ] } ]
PMC9164404	A A Venn diagram revealed the number of genes transcribed in each treatment group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "A", "Venn", "diagram", "revealed", "the", "number", "of", "genes", "transcribed", "in", "each", "treatment", "group", "." ] } ]
PMC11761919	The values represent mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "values", "represent", "mean", "±", "SD", "." ] } ]
PMC10747139	Several studies are addressed here to understand the mechanism of action of Ru(II) complexes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "studies", "are", "addressed", "here", "to", "understand", "the", "mechanism", "of", "action", "of", "Ru(II", ")", "complexes", "." ] } ]
PMC11477621	C NMR (150 MHz, CDCl3) δ 192.4, 171.7, 130.4, 129.7, 119.9, 108.1, 49.8, 32.8, 32.4, 31.1, 28.3, 26.0, 25.1, 9.3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "NMR", "(", "150", "MHz", ",", "CDCl3", ")", "δ", "192.4", ",", "171.7", ",", "130.4", ",", "129.7", ",", "119.9", ",", "108.1", ",", "49.8", ",", "32.8", ",", "32.4", ",", "31.1", ",", "28.3", ",", "26.0", ",", "25.1", ",", "9.3", "." ] } ]
PMC11756514	Recombinant soluble langerin extracellular domain (langerin ECD) was expressed in E. coli and purified using mannose-coupled beads.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recombinant", "soluble", "langerin", "extracellular", "domain", "(", "langerin", "ECD", ")", "was", "expressed", "in", "E.", "coli", "and", "purified", "using", "mannose-coupled", "beads", "." ] } ]
PMC11708541	According to cell cycle analysis, 4-AP therapy made the MCF-7 and MDA MB-231 cell lines go into G1 arrest.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "cell", "cycle", "analysis", ",", "4-AP", "therapy", "made", "the", "MCF-7", "and", "MDA", "MB-231", "cell", "lines", "go", "into", "G1", "arrest", "." ] } ]
PMC11680562	Briefly, 20 mL of T. dioica dried seeds extract was heated on a magnetic stirrer, maintaining a temperature range of 80–90 °C and a stirring speed of 1000 rpm for 30 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "20", "mL", "of", "T.", "dioica", "dried", "seeds", "extract", "was", "heated", "on", "a", "magnetic", "stirrer", ",", "maintaining", "a", "temperature", "range", "of", "80–90", "°", "C", "and", "a", "stirring", "speed", "of", "1000", "rpm", "for", "30", "min", "." ] } ]
PMC10798140	After that, the formazan crystals formed were dissolved by the addition of 50 μL per well dimethyl sulfoxide (DMSO), and the optical density (OD) was measured at 570 nm using a Glomax plate reader (Promega, Madison, WI, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "that", ",", "the", "formazan", "crystals", "formed", "were", "dissolved", "by", "the", "addition", "of", "50", "μL", "per", "well", "dimethyl", "sulfoxide", "(", "DMSO", ")", ",", "and", "the", "optical", "density", "(", "OD", ")", "was", "measured", "at", "570", "nm", "using", "a", "Glomax", "plate", "reader", "(", "Promega", ",", "Madison", ",", "WI", ",", "USA", ")", "." ] } ]
PMC11225860	Cells were then released from the block by washing with fresh media, supplemented with either 100uM Aurkin A (A) or 1µM alisertib and 100µM Aurkin A (B, C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "then", "released", "from", "the", "block", "by", "washing", "with", "fresh", "media", ",", "supplemented", "with", "either", "100uM", "Aurkin", "A", "(", "A", ")", "or", "1µM", "alisertib", "and", "100µM", "Aurkin", "A", "(", "B", ",", "C", ")", "." ] } ]
PMC11711127	Expression of ligands commonly associated with anergic pathways, such as PD-L1, do not strictly define tolerogenic capacity, neither is lack of co-stimulation a pre-requisite (4445).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "of", "ligands", "commonly", "associated", "with", "anergic", "pathways", ",", "such", "as", "PD-L1", ",", "do", "not", "strictly", "define", "tolerogenic", "capacity", ",", "neither", "is", "lack", "of", "co-stimulation", "a", "pre-requisite", "(", "4445", ")", "." ] } ]
PMC9429973	Notably, both immune dysfunction and treatment (e.g. antimicrobials) may influence the CLL microbiome itself and therefore confound cross-sectional clinical studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "both", "immune", "dysfunction", "and", "treatment", "(", "e.g.", "antimicrobials", ")", "may", "influence", "the", "CLL", "microbiome", "itself", "and", "therefore", "confound", "cross-sectional", "clinical", "studies", "." ] } ]
PMC11337594	Recent studies have also reported its inhibitory effects on pancreatic tumors and gastric cancers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", "also", "reported", "its", "inhibitory", "effects", "on", "pancreatic", "tumors", "and", "gastric", "cancers", "." ] } ]
PMC11792766	The third exposure lasted 48 h with medium supplemented with 4.5 µg/mL Cytochalasin B. After treatment, the cells were washed twice with PBS, detached using 0.25% v/v trypsin‐EDTA phenol red solution, neutralized with culture medium, and centrifuged.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "third", "exposure", "lasted", "48", "h", "with", "medium", "supplemented", "with", "4.5", "µg/mL", "Cytochalasin", "B.", "After", "treatment", ",", "the", "cells", "were", "washed", "twice", "with", "PBS", ",", "detached", "using", "0.25", "%", "v/v", "trypsin‐EDTA", "phenol", "red", "solution", ",", "neutralized", "with", "culture", "medium", ",", "and", "centrifuged", "." ] } ]
PMC7039683	Pelleted nuclei were resuspended in 50 µL tagmentation reaction mix (25 µL Nextera TD Buffer, 2.5 µL Nextera TD Enzyme, and 22.5 µL H2O, all from the Nextera DNA Sample Preparation Kit [Illumina]).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pelleted", "nuclei", "were", "resuspended", "in", "50", "µL", "tagmentation", "reaction", "mix", "(", "25", "µL", "Nextera", "TD", "Buffer", ",", "2.5", "µL", "Nextera", "TD", "Enzyme", ",", "and", "22.5", "µL", "H2O", ",", "all", "from", "the", "Nextera", "DNA", "Sample", "Preparation", "Kit", "[", "Illumina", "]", ")", "." ] } ]
PMC11420784	PI3P is a regulator mainly affecting cellular membrane trafficking.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PI3P", "is", "a", "regulator", "mainly", "affecting", "cellular", "membrane", "trafficking", "." ] } ]
PMC11525028	Scale bars: 200 μm.(F) Quantification of area of organoids derived from patient 1 (P1) treated with paliperidone, AG-401, or combination..(G and H) Tumor growth (G) and survival (H) of the PDX model treated with paliperidone (2 mg/kg daily, i.p.),	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ":", "200", "μm.(F", ")", "Quantification", "of", "area", "of", "organoids", "derived", "from", "patient", "1", "(", "P1", ")", "treated", "with", "paliperidone", ",", "AG-401", ",", "or", "combination", "..", "(G", "and", "H", ")", "Tumor", "growth", "(", "G", ")", "and", "survival", "(", "H", ")", "of", "the", "PDX", "model", "treated", "with", "paliperidone", "(", "2", "mg/kg", "daily", ",", "i.p", ".", ")", "," ] } ]
PMC10914904	These prosurvival proteins are located on the external mitochondrial membrane and are implicated in preventing intrinsic and extrinsic cell death in several cell types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "prosurvival", "proteins", "are", "located", "on", "the", "external", "mitochondrial", "membrane", "and", "are", "implicated", "in", "preventing", "intrinsic", "and", "extrinsic", "cell", "death", "in", "several", "cell", "types", "." ] } ]
PMC11697703	However, miR-365 is capable of regulating dendritic branching and is needed in combination with miR-193b to regulate spine density.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "miR-365", "is", "capable", "of", "regulating", "dendritic", "branching", "and", "is", "needed", "in", "combination", "with", "miR-193b", "to", "regulate", "spine", "density", "." ] } ]
PMC8735881	As shown in Figure 1(C), the fluorescent intensities of the TZM-bl cells transduced with GPI-scFvs were comparable to those of the parental TZM-bl cells (mock), indicating the expression of scFvs had no appreciable effect on the expression of the primary HIV-1 receptor CD4 and two coreceptors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "shown", "in", "Figure", "1(C", ")", ",", "the", "fluorescent", "intensities", "of", "the", "TZM-bl", "cells", "transduced", "with", "GPI-scFvs", "were", "comparable", "to", "those", "of", "the", "parental", "TZM-bl", "cells", "(", "mock", ")", ",", "indicating", "the", "expression", "of", "scFvs", "had", "no", "appreciable", "effect", "on", "the", "expression", "of", "the", "primary", "HIV-1", "receptor", "CD4", "and", "two", "coreceptors", "." ] } ]
PMC11371627	The XK gene, located in the Xp21.1 region of the X-chromosome, codes for the transmembrane XK protein which forms a heterodimer with the Kell protein (Figure 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "XK", "gene", ",", "located", "in", "the", "Xp21.1", "region", "of", "the", "X-chromosome", ",", "codes", "for", "the", "transmembrane", "XK", "protein", "which", "forms", "a", "heterodimer", "with", "the", "Kell", "protein", "(", "Figure", "1A", ")", "." ] } ]
PMC11622247	During DNA synthesis, alkyne-modified uridine was coupled at varied distances to the N-Tfa-protected serinol nucleotide (STfa).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "DNA", "synthesis", ",", "alkyne-modified", "uridine", "was", "coupled", "at", "varied", "distances", "to", "the", "N-Tfa-protected", "serinol", "nucleotide", "(", "STfa", ")", "." ] } ]
PMC11429241	However, the scaffold models presented here have some limitations, as they have not yet reached a level of complexity that allows us to fully mimic the ECM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "scaffold", "models", "presented", "here", "have", "some", "limitations", ",", "as", "they", "have", "not", "yet", "reached", "a", "level", "of", "complexity", "that", "allows", "us", "to", "fully", "mimic", "the", "ECM", "." ] } ]
PMC10033453	Cell lines were plated at 1e4 cells/well in a 96-well plate and rested overnight in a 37°C/5% CO2 incubator.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "lines", "were", "plated", "at", "1e4", "cells/well", "in", "a", "96-well", "plate", "and", "rested", "overnight", "in", "a", "37", "°", "C/5", "%", "CO2", "incubator", "." ] } ]
PMC11291490	ns > 0.05, P < 0.05, P < 0.01, P < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ns", ">", "0.05", ",", "P", "<", "0.05", ",", "P", "<", "0.01", ",", "P", "<", "0.001", "." ] } ]
PMC9964635	Yield 73%, m.p 122–124 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yield", "73", "%", ",", "m.p", "122–124", "°", "C", "." ] } ]

PMC11519583

c MPs, transfected with the indicated siRNAs, followed by treatment with cytochalasin D, were stained with an anti-lamin B1 antibody (magenta) and DAPI (cyan).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "MPs", ",", "transfected", "with", "the", "indicated", "siRNAs", ",", "followed", "by", "treatment", "with", "cytochalasin", "D", ",", "were", "stained", "with", "an", "anti-lamin", "B1", "antibody", "(", "magenta", ")", "and", "DAPI", "(", "cyan", ")", "." ] } ]

PMC11347429

The respective raw and normalized data are available at the GEO (GEO) public database (see Table 1 for availability of supplementary data and tables).

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PMC11087766

Mapping the nonconserved amino acids in this region to the AlphaFold-predicted structure (35) of PhiKZ gp104 shows that they are part of an exposed surface of the protein that we call the recognition region (Fig. 1E).

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PMC10887351

Indeed, β3-AR antagonism on tumor-infiltrating lymphocytes (TILs) reduced their ability to produce IFN-γ, which reduced the expression of PD-L1 provoked by TILs infiltration into NB tumor cells.

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PMC11721064

Inhibition of STAT3 blocked the activation of PI3K/AKT signaling pathway and impaired corneal epithelial cell transdifferentiation.

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PMC7215722

E.E. Sterchi and H.-P. Hauri, formerly at the University of Bern and University of Basel, Switzerland, and Dr. B. Nichols, Baylor College of Medicine, Houston, USA).

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PMC11476106

Increased VN secretion has been associated with the bodily response to tissue damage or inflammation in studies with hepatic tissues, indicating that cells are trying to survive .

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PMC11300639

e–k 786-O and A498 cells were infected with indicated shRNAs for 72 h. Then, these cells were treated with or without Everolimus and subjected to western blotting, transwell, CCK-8, tube formation, and nude mouse xenografts assay.

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PMC11574271

The identification of the hsa-miR-659-3p/RON and RON/JNK/HIF-2α/MMP12 pathways offer valuable insights into the pathogenesis of bladder cancer and may serve as potential targets for therapeutic interventions in the management of this disease.

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PMC4005030

Protocatechuic acid (PCA) is widely distributed and present in most edible plants used in folk medicine .

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PMC9046263

RNA was isolated from NHA, A172, GBM28, and GBM43 using Trizol extraction with chloroform as previously described.

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PMC9429973

A 3 vaccine dose to complete primary vaccination has since been recommended.

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PMC8427838

786-0 cells expressing TMIGD1 alone or with other constructs were stained for actin, as described above, and visualized using an inverted epifluorescence microscope.

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PMC10297204

Therefore, this study proved that ethanol adjuvant therapy with 30% concentration has anti-tumor effects after surgery for STS with a close margin to the sciatic nerve without increasing the risk of neurotoxicity.

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PMC10452486

Furthermore, several reports have emerged postulating independent surface expression of Face-2, without dissociating from Face-1 .

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PMC6222726

Their leaves are imparipinnate, sometimes bipinnate, up to 30 cm long and 18 cm wide, with 7 to 11 leaflets.

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PMC10933092

Kaplan-Meier analysis examines the prognostic value of the four transcripts according to their median expression levels in BLCA tissues.

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PMC9429973

Therefore, there is a need for a modified conditioning regimen that can enhance anti-leukemic effects in aggressive diseases such as acute leukemia.

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PMC11180402

A Relative SOX2 mRNA levels in 5637 cells treated with 20 μM ISO at indicated times by RT-qPCR. (

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PMC11534035

At 1 μM, an average of 45.67±38.69 colonies were formed (p<0.005).

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PMC11806818

The preparation process of Apt/Fe-N-C SAzymes and the principle of colorimetric detection of cancer cells.

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PMC11741906

The expression levels were normalized to SNORD95 and relative to A2780 cells.

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PMC11632064

Rho-0 cells still possess mitochondria, but they are part of fragmented networks and show no respiratory activity.

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PMC11295144

Cultured cells were lysed with 2% SDS and the protein concentration determined using the BCA assay (Thermo Fisher Scientifics).

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PMC6461034

Transfer the supernatant from the previous spin (peptide solution) to an “IP” tube with 20 μl aliquoted antibody‐conjugated beads, pipetting directly on top of the beads (without touching).

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PMC7840816

Some reports demonstrated that SOX9 was overexpressed in gastric carcinoma, breast cancer, pancreatic ductal adenocarcinoma, and glioma (9–12), whereas other studies showed that SOX9 may function as a tumor suppressor, such as in bladder cancer and melanoma (13,14).

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PMC10914904

During inflammation-associated cancer, the binding of NF-κB to gene promoters induces the expression of cytokines such as TNF-α, IL-1B, and IL-6, thereby facilitating cell proliferation, invasion, angiogenesis, and macrophage polarization in several tumors [156–158].

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PMC11467964

The K–M curve revealed that STS patients had a markedly better OS in low‐risk group (p < .05, Figure 5E).

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PMC8526701

Furthermore, the pharmacological inhibition of BRD9 with the help of a small molecular inhibitor, GSK602, exerts a significant antitumorigenic effect in different types of cancers.

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PMC11351758

Cytochrome C release from the mitochondria is the ultimate effect of peroxidized CL on mitochondria .

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PMC9611901

The increased levels of primary DNA damage measured in these cells were apparently due to complex interactions between highly reactive compounds of natural origin that were efficiently released into the cell medium due to their high solubility.

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PMC6190245

F. gummosa also exhibited a significant anti-proliferation and apoptosis-inducing effect on gastric cancer (Gharaei et al., 2011 ▶).

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PMC11366496

The tissues and cells underwent lysis and were quantified using RIPA buffer and bicinchoninic acid (BCA) (Servicebio, Wuhan, China).

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PMC11549062

In our study, we found that increased PTP1B expression leads to apoptosis, suppresses carotid VSMCs migration and proliferation, and promotes the vulnerability of carotid plaque.

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PMC11731614

Nevertheless, this study enhances our understanding of the communication between keratinocytes and DRG neurons via KDEVs.

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PMC6160470

As expected, A2780/Adr cells showed cross-resistant phenotype.

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PMC11753435

Raw, uncropped blots are shown in fig. S4.

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PMC11467800

The white arrows indicate a new vessel formation near the SIV. (

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PMC11774747

Several explanations have been proposed, including a lower avidity of VST TCR for the allogeneic epitope compared to the viral epitope, and the role of immunosuppressive regimens in transplanted patients.

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PMC10955424

Our findings, as shown in Fig. 1, demonstrated that the preponderance of malignant ascites—more than 85 %—were active in conferring platinum chemoresistance to OC cells.

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PMC11547972

Rather, cell signaling was differentially modulated, depending on the cell line and applied drug.

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PMC10440586

The next three tracks indicate the P value of three transcriptional subtypes.

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PMC11190238

Within CTs, there are chromatin compartments, comprising A compartments with open euchromatin enriched in highly expressed genes, and B compartments with closed heterochromatin associated with repressed transcription regions.

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PMC11265931

Our findings support the idea that SEVs produced from garlic may trigger apoptotic cell death in cancer cells while having no effect on healthy cells.

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PMC11676674

In this work, the metabolite composition of methanolic extracts obtained from C. monspeliensis leaves was evaluated using an untargeted metabolomic approach by UPLC analysis coupled to High Resolution Mass Spectrometry (HRMS).

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PMC11144382

We used MEFs derived from wild-type (WT; Nfix) mice, and previously established Nfix, Nfix, Nfix, Nfix, Nfix and Nfix mutant mice that had deletions in exon 7 comprising: a 140 nucleotide deletion (Del140) that caused skipping of exon 7 due to alternative splicing of exon 6 to exon 8 and production of wild-type short Nfix isoforms that lack exon 7; an in-frame 24 nucleotide deletion (Del24) which caused loss of 8 amino acids; and a 2 nucleotide deletion (Del2) that caused a frame shift and a premature termination.

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PMC11469524

We performed a profile likelihood analysis that unveiled that about half of the non-inhibitor coefficient (path)s (11 of 21, asterisks Fig 2E) are significantly different, i.e., the 95% pointwise confidence intervals do not overlap.

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PMC11592837

Nonetheless, a combined monitoring of both markers in future clinical studies with patient material should prove a superior diagnostic outcome.

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PMC11011837

Heatmap visualization was applied on the lipidomic data matrix to study the quantitative differences among the single lipids inside the different cell lines.

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PMC9096373

Calculation of apoptosis was similar to those with VEGFR-2.

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PMC6835428

The ideal cellular model should be able to replicate the main phenotypic and genetic characteristics of OC cells.

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PMC11138140

As expected, the norepinephrine-treated cardiomyocytes exhibited significant spreading and formed cellular protrusions by the end of the 24 h treatment relative to the untreated controls (Figure 1C), which is consistent with previous observations .

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PMC11755624

Stimulated keratinocytes release immunoregulatory mediators such as IL-19 and IL-36 (Figure 1).

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PMC9065483

We found that upon stimulation using IFNβ, vanadate treatment led to concentrated nuclear localization of phosphorylated STAT1 compared with cells only treated with IFNβ, where nuclear phospho-STAT1 signal was more diffuse (Figures 3D and S11).

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PMC11758416

Discard supernatant from staining plate or FACS tubes and begin staining steps.

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PMC9424261

HERPUD1 is an endoplasmic reticulum (ER) membrane protein that is generally expressed and highly induced during unfolded protein responses (UPR) and cell stress .

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PMC11087055

If the bilateral rotating cell flow is required for PS formation, both the authentic and induced PSs should each be accompanied by polonaise movements during the extension.

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PMC9111184

The obtained results showed that even with a diet rich in cholesterol, hydroxycinnamic acid derivatives and EZ have a high permeability and allow them to enter the blood stream and reach other organs such as the liver where they showed an effect cholesterol biosynthesis inhibition through the inhibition of the enzyme HMGR and the regulation of cholesterol transporter proteins responsible of cholesterol excretion (Arantes et al., 2016; Guedes et al., 2019; Ressaissi et al., 2017, 2020).

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PMC11244823

At least two previous studies have shown that the receptor-binding protein, glycoprotein D (gD), drastically affects if not determines both the host range and the clinical severity of EHV-infections .

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PMC11737091

After activation by the DBF4 subunit, CDC7 directly phosphorylates the MCM 2–7 complex .

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PMC11802855

After CD138 magnetic bead sorting, we performed high-throughput transcriptome sequencing, identifying 52 differentially expressed genes (|logFC | > 1, FDR < 0.01) (via DESeq2) (Fig. 1A).Fig.

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PMC11790971

Advancements in ML techniques have greatly enhanced the feasibility and popularity of high-content single-cell profiling.

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PMC11023271

LPA also exists in many isoforms .

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PMC10729469

B, F Data presented as mean ± SEM.

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PMC9429973

These survival measures were presented by year of diagnosis for four ages at diagnosis (i.e., 40, 50, 60, and 70 years), stratified by sex.

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PMC9429973

All patients received LD before infusion, fludarabine/bendamustine in HL patients (n=8) and fludarabine/cyclophosphamide in T-NHL (n=2).

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PMC9429973

In 21 patients from Iven group, with a median follow-up of 7.4 months, a complete remission was achieved (72.4%); of these, 8 had unmeasurable MRD.

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PMC11529598

p < 0.05.

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PMC11675244

For instance, Wnt-5a, commonly involved in neural crest cell migration, decreases its expression once cells reach their destination tissue .

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PMC11740907

The versatile nature of beeswax, acting as a lipid matrix, facilitates the encapsulation of hydrophobic medicines, hence playing a crucial role in the creation of effective and secure drug delivery systems.19 Furthermore, its sustainable and renewable characteristics are in line with the increasing focus on green formulations in the field of pharmaceuticals.20 The process entails constructing three-dimensional structures of the molecules, optimizing energy, and producing numerous binding positions.

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PMC11637276

Therefore, to prevent lysosomal degradation and discern between changes that could be due to altered ECM degradation rather than endocytosis, cells were treated with a cysteine-cathepsin lysosomal inhibitor, E64d .

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PMC11548041

Aptamer-based therapies have several advantages over conventional monoclonal antibody therapies such as superior solid tumor penetration and amenability to engineering.

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PMC7840816

Knockdown of SOX9 inhibited cell growth and invasion by suppressing the Wnt/β-catenin signaling in PTC cells.

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PMC11757230

Animals were handled in accordance with the animal care guidelines of the Institute of Laboratory Animal Resources of Nippon Veterinary and Life Science University, which conform to national guidelines, and international guidelines such as the ARRIVE guidelines.

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PMC6901583

This process involves angiogenic factors, such as bFGF, PDGFB, and VEGF secreted by the cells of the tumor.

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PMC9164404

A A Venn diagram revealed the number of genes transcribed in each treatment group.

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PMC11761919

The values represent mean ± SD.

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PMC10747139

Several studies are addressed here to understand the mechanism of action of Ru(II) complexes.

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PMC11477621

C NMR (150 MHz, CDCl3) δ 192.4, 171.7, 130.4, 129.7, 119.9, 108.1, 49.8, 32.8, 32.4, 31.1, 28.3, 26.0, 25.1, 9.3.

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PMC11756514

Recombinant soluble langerin extracellular domain (langerin ECD) was expressed in E. coli and purified using mannose-coupled beads.

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PMC11708541

According to cell cycle analysis, 4-AP therapy made the MCF-7 and MDA MB-231 cell lines go into G1 arrest.

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PMC11680562

Briefly, 20 mL of T. dioica dried seeds extract was heated on a magnetic stirrer, maintaining a temperature range of 80–90 °C and a stirring speed of 1000 rpm for 30 min.

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PMC10798140

After that, the formazan crystals formed were dissolved by the addition of 50 μL per well dimethyl sulfoxide (DMSO), and the optical density (OD) was measured at 570 nm using a Glomax plate reader (Promega, Madison, WI, USA).

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PMC11225860

Cells were then released from the block by washing with fresh media, supplemented with either 100uM Aurkin A (A) or 1µM alisertib and 100µM Aurkin A (B, C).

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PMC11711127

Expression of ligands commonly associated with anergic pathways, such as PD-L1, do not strictly define tolerogenic capacity, neither is lack of co-stimulation a pre-requisite (4445).

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PMC9429973

Notably, both immune dysfunction and treatment (e.g. antimicrobials) may influence the CLL microbiome itself and therefore confound cross-sectional clinical studies.

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PMC11337594

Recent studies have also reported its inhibitory effects on pancreatic tumors and gastric cancers .

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PMC11792766

The third exposure lasted 48 h with medium supplemented with 4.5 µg/mL Cytochalasin B. After treatment, the cells were washed twice with PBS, detached using 0.25% v/v trypsin‐EDTA phenol red solution, neutralized with culture medium, and centrifuged.

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PMC7039683

Pelleted nuclei were resuspended in 50 µL tagmentation reaction mix (25 µL Nextera TD Buffer, 2.5 µL Nextera TD Enzyme, and 22.5 µL H2O, all from the Nextera DNA Sample Preparation Kit [Illumina]).

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PMC11420784

PI3P is a regulator mainly affecting cellular membrane trafficking.

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PMC11525028

Scale bars: 200 μm.(F) Quantification of area of organoids derived from patient 1 (P1) treated with paliperidone, AG-401, or combination..(G and H) Tumor growth (G) and survival (H) of the PDX model treated with paliperidone (2 mg/kg daily, i.p.),

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PMC10914904

These prosurvival proteins are located on the external mitochondrial membrane and are implicated in preventing intrinsic and extrinsic cell death in several cell types.

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PMC11697703

However, miR-365 is capable of regulating dendritic branching and is needed in combination with miR-193b to regulate spine density.

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PMC8735881

As shown in Figure 1(C), the fluorescent intensities of the TZM-bl cells transduced with GPI-scFvs were comparable to those of the parental TZM-bl cells (mock), indicating the expression of scFvs had no appreciable effect on the expression of the primary HIV-1 receptor CD4 and two coreceptors.

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PMC11371627

The XK gene, located in the Xp21.1 region of the X-chromosome, codes for the transmembrane XK protein which forms a heterodimer with the Kell protein (Figure 1A).

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PMC11622247

During DNA synthesis, alkyne-modified uridine was coupled at varied distances to the N-Tfa-protected serinol nucleotide (STfa).

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PMC11429241

However, the scaffold models presented here have some limitations, as they have not yet reached a level of complexity that allows us to fully mimic the ECM.

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PMC10033453

Cell lines were plated at 1e4 cells/well in a 96-well plate and rested overnight in a 37°C/5% CO2 incubator.

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PMC11291490

ns > 0.05, P < 0.05, P < 0.01, P < 0.001.

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PMC9964635

Yield 73%, m.p 122–124 °C.

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