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PMC10777969
Ovarian (A2780), breast (MCF-7), cervix (HeLa), colon (LoVo), and brain (MO59J and MO59K) cell lines were purchased from the American Type Culture Collection (ATCC; Rockville, MD, USA), except A2780 (Sigma-Aldrich, St. Louis, MO, USA).
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PMC8708099
The number of patients suffering from inflammation-associated intestinal disorders has increased dramatically in developed countries, and a variety of factors are known to influence this phenomenon .
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PMC11569208
Cells were lysed 24 h later and RNA was extracted.
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PMC11656048
And then washed twice with warm HBSS and harvested by trypsinization.
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PMC9429973
The proportional hazards assumption was evaluated graphically using log minus log plots.
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PMC10998613
Like other chemokine receptors, CXCR4 can form homodimers (14), trimers (16), and higher-order complexes (17).
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PMC9429973
The average adverse outcome occurrence among patients segmented by HbF ranges/thresholds were described in 40 analyses.
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PMC9429973
The overall response rate (ORR) was 95.9% after 2 courses of induction therapy, with 13.5% achieving the deep response (complete response (CR) or better) and 51.3% of patients achieving a very good partial response (VGPR) or better.
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PMC11612626
Digested samples were labeled with TMTpro (Thermo Fisher Scientific, Lot# YD368822).
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PMC10568263
Secondly, l-cysteine has an NH2 functional group that can interact with negatively charged [Fe(CN)6], thereby increasing electron diffusion.
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PMC11745600
Nonfasting blood glucose levels (A and B) and weight changes with age (C and D) in male (wt, n = 5; C96Y/+, n = 12; and C96Y/C96Y, n = 5) and female (wt, n = 6; C96Y/+, n = 7; and C96Y/C96Y, n = 9) mice.
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PMC10965315
p53 is a tumor suppressor gene that transcriptionally regulates multiple genes in different pathways and plays a momentous role in regulating cell division and preventing the formation of cancerous cells (Hernández Borrero & El‐Deiry, 2021).
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PMC4816271
All constructs were generated by splicing by overlap PCR.
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PMC7305184
We thus assumed these differences are most probably a result of experimental errors and can as such be considered random.
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PMC10547921
This latter hydrogen bond network arranges the aromatic ring in Tyr β224 in a π-stacking interaction with the nucleobase of GDP, preventing its dissociation from β-tubulin.
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PMC11590870
As for the latter, ROSs react with the genetic material of cells, inducing somatic mutations that, when accumulated, promote the appearance of malignant cells, which have been linked to the onset and development of several types of cancer.
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PMC9429973
median (range); N (%) The probability of reaching consecutive treatment lines decreased in all age groups, but most strikingly in that of the oldest patients (Fig.).
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PMC11499381
To simplify the nomenclature, these epitope tags are omitted from the descriptions of the receptors.
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PMC11257203
M. Evazalipour and E. Zamani contributed to the conceptualization, study design, project supervision, and manuscript writing.
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PMC11742231
The molecular structures of the drugs were sourced from PubChem . (
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PMC11388384
LiCor goat anti-mouse and goat anti-rabbit secondary antibodies were used to detect primary antibodies, and membranes were imaged using a Licor Odyssey Clx fluorescence scanner.
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PMC10391797
Specific lysis effect of CD123 and CLL-1 CAR-T cells evaluated by flow when co-cultured with AML cell lines THP-1 and MV411 at an effector/target (E/T) ratio of 1:1.
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PMC10589262
G Cell viability of GIST cells treated with 0.1 µM TG and PF was measured after 24 and 48 h. H Immunoprecipitation of GIST cell lysates was performed with a control IgG or KIT antibody, and western blotting was performed against chaperones.
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PMC11739484
Panel (B) illustrates GEPIA2 based-based mRNA expression of MMP7, MMP11, and MMP14 genes in skin cutaneous melanoma (SKCM) samples of different cancer stages and control samples.
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PMC5311252
This analysis revealed that the correlations found in the LUAD analysis were present also for other cancer types.
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PMC5600151
Other modifications can impact cancer targeting properties, for instance, following conjugation with tumor specific antibodies and folic acid (Figure 2).
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PMC9429973
Results: Trial in progress.
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PMC11774747
The reported studies suggest that enhancing the durability and expansion of CAR-VSTs, particularly through strategies like viral reactivation or vaccination, could improve therapeutic outcomes.
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PMC11371627
For an overview of clinical work-up of our patient, please see Supplementary Figure 1B.
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PMC9412887
In addition, they have shown delayed drug release or rapid drug release based on the crosslinker degradation in response to the tumor microenvironment (TME).
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PMC11621565
At 1 µg/ml, levels were similar to the control.
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PMC10996034
It was hypothesized that MMP1 may affect cell migration through ANGPTL4, leading to the generation of drug resistance.
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PMC9436459
In a branch procedure, precursors S25 and S26 were subjected to the same Horner-Wadsworth-Emmons reaction and deprotection conditions, and then reprotected with MOM groups to produce iodide S30, which performed the Heck reaction with 2-methyl-but-3-en-2-ol followed by dehydration to provide the desired MOM protected diene S31.Scheme 3Syntheses of dienes S28 and S31 by the Lei group Syntheses of dienes S28 and S31 by the Lei group The critical factor for the symmetric Diels − Alder cycloaddition between diene S28 and the known dienophile S32 was to find a suitable chiral ligand.
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PMC11596967
They were then incubated with 2 μM JC-1 dye for 15 min at 37 °C in an atmosphere containing 5% CO2, followed by two PBS washes.
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PMC11711063
Comparison of ZG16B protein expression in lesion‐free mammary glands of MMVT‐ErbB2 transgenic mice after 8 weeks of vehicle or Bex + Carv treatments. (
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PMC6889484
As outlined by the dynamic copy choice model for retroviral recombination, duplicated gene sequences are precisely and accurately deleted at a high efficiency by homologous recombination during the process of reverse transcription.38, 39, 40, 41, 42, 43 Here, we developed a self-activating lentiviral vector that utilized directly repeated sequences of a Vif-resistant mutant of A3G (A3G-D128K) to prevent expression of A3G-D128K in the lentivector producer cells but reconstituted a functional A3G-D128K in the target cells during retroviral transduction.
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PMC5574817
The hERG mRNA expression was determined by analyzing the threshold cycle (Ct) value for each RNA sample extracted from both transfected HEK293-HERG cells and non-transfected HEK293 cells (control).
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PMC11754784
When using CD47 Nb to complete the binding between monoclonal antibody B6H12-PE and target cell, cells were first washed with DPBS three times and incubated with B6H12-PE at 4 °C for 30 min.
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PMC9429973
We assessed red cell fragility parameters and eosine-5-maléimide (EMA), band 3 protein-binding dye, as an indicator of a membrane protein deficiency.
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PMC11711127
Fighting T cell exhaustion is at the core of current cancer immunotherapy efforts, with more than 5,000 ongoing clinical trials worldwide targeting PD-1/PD-L1 pathways, with a growing body of combination therapies; including chemotherapy agents, anti-angiogenic therapeutics or other immune modulators, such as anti-CTLA4, anti-LAG-3, or IL-2 variants (173).
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PMC4369959
The suppression of tumor growth was found to be linked with the inhibition of leukotriene A4 hydrolase activity, which was further confirmed by in silico approach .
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PMC11438317
HS1 and Vav were also dephosphorylated, although at a slower rate.
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PMC11623887
GATA1 is one of the main transcription factors in the regulation of erythroid cells gene expression.
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PMC9429973
The ELSNCS has been recruiting consecutive infants diagnosed within a universal newborn screening programme since 1983.
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PMC10976516
This can raise the expression of adhesion molecules, stimulate leakiness within the tumor’s blood vessels, and cause the release of cytokines, which may facilitate the homing or extravasation of carrier cells from blood vessels into the tumor.
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PMC9429973
Zanubrutinib (160 mg po bid) plus R-CHOP (ZR-CHOP) was administered in TN cohort, and Zanubrutinib (160 mg po bid) combined with investigator-determined conventional salvage chemotherapy (CSC, including ICE, DHAP, GDP, or GemOx, +/- rituximab) was administered in R/R cohort.
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PMC11774747
The source of these VSTs can be the allo-SCT donor or a different donor, known as a third-party donor, which can overcome issues associated with the lack of availability of an allogeneic HPC donor for the generation of donor-derived VSTs.
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PMC9429973
In the low probability group, overtesting for HIT is highly prevalent.
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PMC11389534
Further research is necessary to establish if ODR4 also influences the activity of UFSP2, in addition to its known role in localisation and stability.
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PMC11506827
Overall, these findings highlight the potential of GEF and TRAIL combination therapy to induce apoptosis by modulating apoptotic proteins involved in both extrinsic and intrinsic pathways.
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PMC11754436
A-D) Identification of interaction correlation and survival analysis of target genes. (
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PMC11472639
Fig. 3 Representative gating strategy for NK-cells.
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PMC9545714
The measurements were made on the left cheek on an area from the outer corner of the eye and on a plane with the small pointed eminence of the external ear (tragus).
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PMC9545474
The plates were further incubated for 72 h at 37 °C and a 5 % CO2 humidified atmosphere to allow for a period of recovery.
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PMC11767582
The regioselective formation of the 1,5-disubstituted triazoles was originally described by Sharpless and is explained by the mechanism illustrated in Scheme 1.
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PMC11711871
More clinical data are needed to determine whether adrenal hyperplasia is a prerequisite for developing hypertension .
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PMC10565698
The supernatant was aspirated and used as the nuclear RNA fraction.
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PMC11750161
Therefore, we concluded that activating eel LH/CGR mutants exhibit continuous signaling without agonist stimulation.
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PMC9429973
This “late-start” strategy was thought to minimize toxicity risks of iron depletion from biological stores or iron-bound proteins, such as transferrin, observed during “early-start” studies with DFO.
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PMC9429973
Goodness-of-fit was assessed using the Akaike Information Criterion and Bayesian Information Criterion.
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PMC11092382
Most of those studies were performed without sufficient mechanistic studies.
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PMC11705862
Error bars indicate SD To study the functional outcome of IRIS-1, and IRIS-2 expression in SH-SY5Y cells, we performed the knockdown of all the CD59 splice variants as no specific siRNAs are available that can distinguish between these three transcripts.
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PMC11218145
Translating to mammalian cells, the impairment of ATP synthase largely affects mitochondrial structure and functions.
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PMC9429973
In this study, CD3+ T cells from the CB samples were selected, activated, and modified by lentivirus to produce anti-BCMA CAR-T cells.
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PMC11155445
Four novel analogs of 1-allyl-3-benzoylthiourea (100a–d) were synthesized and evaluated for their antibacterial activity against S. aureus, S. typhi, E. coli, and P. aeruginosa (Fig. 36).
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PMC7812570
A fusion gene sequentially encoding m36.4 or the scFv of FluIgG03, a His tag, and a GPI attachment signal (C-terminal 34 amino acid residues of DAF) was designed, synthesized (Genwiz, China) and then ligated into a self-inactivating lentiviral transfer vector carrying an hPGK promoter (pRRLsin.
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PMC9429973
Some other SNPs (like rs35629860 and rs67128646) in the same LD block show the co-occurrence of H3K4me3 and H3K27me3 histone marks (associated with gene activation and repression, respectively) in promoters and enhancers in B lymphocytes.
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PMC9429973
Results: A subgroup of 58 JAKARTA2 patients with an Eastern Cooperative Oncology Group performance status (ECOG PS) score of 0 or 1 and intermediate-2 or high-risk disease most closely aligned with the REFINE population (N=34) was used in the analyses.
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PMC11648299
One strength of our investigation is the analysis of retinoid use which is common in this patient group.
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PMC11291490
DuPBMCs were isolated as mentioned above.
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PMC11348300
PpIX has a red DF emission (Fig. 2E) that has not been widely acknowledged prior to now but is significantly amplified by the lack of oxygen around it (16, 40) (Fig. 2F), such as the microregional hypoxia present in most solid cancers (41–45).
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PMC11701801
P < 0.05; **, P < 0.01; ***, P < 0.001.
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PMC10940855
Multiple myeloma cells (U266, NCI-H929, RPMI-8226) were purchased from ATCC and cultured in RPMI1640 medium containing 25 mmol/L HEPES, l-Glutamine (Thermo Fisher Scientific, 11875093) and 15% FBS.
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PMC10898159
LMTK3 knockdown not only directly decreases KIT protein translation, but also inhibit the expression of PKC and KIT phosphorylation, indicating LMTK3 as a druggable target.
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PMC7057940
no. 7477-40-7; Sigma-Aldrich; Merck KGaA) followed by fixation with 3:1 methanol (cat.
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PMC11721064
Images showed that during the purification process, circular cells gradually disappeared, and dormant fibroblasts mainly aggregated in P2 LNCs (scale bar = 50 μm).
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PMC11509278
The proportions of the level 1 classification of differentially abundant metabolites of A431 cells treated with EEP in positive ion mode were as follows: metabolism, 68.57%; organismal systems, 13.33%; human diseases, 8.57%; environmental information processing, 4.76%; cellular processes, 2.86%; and genetic information processing, 1.90% (Figure 4A).
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PMC11650848
The placebo G/G group symbol search and cancellation scores diverge away from the other groups.
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PMC11661024
Therefore, these results confirmed the release of cytochrome c after activation of the mitochondrial pathway by the downregulation of RelA and iKB genes, along with elevating the expression of Bax/Bcl2, thus consequently enhancing apoptosis.
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PMC11206502
Significant differences between basal and stressed OCR values, tested by the Mann–Whitney test, were registered only for the positive control (p = 0.0002), with a decrease in the OCR values in a stressed state.
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PMC10858941
By performing immunofluorescence in our GBM-on-a-Chip model, we could observe a clear accumulation of p62 in the outermost areas of the tumour after NNC application compared to untreated chips from both GBM cell lines.
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PMC9429973
OS did not differ between patients experiencing AF or not.
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PMC4270159
M14VarianceF (2, 6)ηPEffect size fPowerTotal sample size across all groups2%12500.99760620.413599.99%615%22.22220.8810572.72165290.90%628%6.37760.6800891.45803685.39%940%3.1250.5102041.02062188.33%15KHM-S3VarianceF (2, 6)ηPEffect size fPowerTotal sample size across all groups2%6890.82120.99956547.935999.99%615%122.50350.9760966.39014999.99%628%35.15730.9213783.42331598.12%640%17.22710.8516842.39632283.59%6 In order to produce quantitative replication data, we will run the experiment three times.
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PMC11779960
In this light, the 5% threshold adopted by Thiele et al. is likely too low and even the arbitrary 25% threshold proposed by Iyer et al. may not exclude infiltrating normal T cells.
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PMC11680982
Further analysis by flow cytometry and western blot unveiled the ability of neratinib to induce G1 phase arrest, accompanied by downregulation of Cyclin D1, CDK4, HER2, and EGFR (P < 0.05) (Fig. 4C,D).
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PMC11012313
Our current information suggests that an mTOR-dependent enhancement of ATP production and HIF-1α levels may contribute to this LMP2A-dependent enhancement in MYC-driven tumor development and potentially the need to bypass additional oncogenic mutations.
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PMC7612475
Following treatment and appropriate recovery as indicated, cells were fixed in 4% PFA/PBS and then permeabilized in 0.4% Triton X-100/PBS followed by blocking in 3% BSA/PBS.
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PMC9351137
After washing in PBS, the coverslips were counterstained with DAPI and mounted onto slides with ProLong™ Diamond Antifade Mountant (Invitrogen).
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PMC10849234
HL-60 or PLB-985 cells were differentiated into Neutrophil-like cells (NLCs) and tested for exocytosis of primary granules. (
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PMC10006224
units, arbitrary units) of control or NIPBL KD HeLa cells stained with antibodies against STAG1, STAG2 and SMC1A.
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PMC9429973
Aims: As cross-sectional studies failed to identify unifying determinants of relapse, we adopted a longitudinal strategy and performed multi-omic analyses in 13 matched pairs of initial diagnosis and relapse samples and their matched PDXs.
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PMC9429973
Subgroup analysis stratifying COVID-19 patients by age (≥50 years old), COVID-19 mRNA vaccination before acquiring SARS-CoV-2 infection, or pre-existing cardiovascular risk factors did not show any statistically significant differences across haemostatic, endothelial or inflammatory parameters.
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PMC9429973
Figure1 H-I) Image: Summary/Conclusion: Paeoniflorin could significantly reduce peripheral neuropathy caused by bortezomib, which might be achieved by reducing IL6 levels to regulate PARKIN-mediated mitochondrial autophagy and mitochondrial damage.
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PMC11489351
The lactate assay kit (Sigma, MAK066) is a colorimetric assay that measures lactate concentration (0.2–10 nmoles of lactate) in a biological sample and is determined by an enzymatic assay leading to a readout that is proportional to the lactate present in the sample.
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PMC11349530
It is crucial for the tumorigenic capacity of tumor-initiating cells (TICs), also known as cancer stem cells, which drive cancer progression and resistant to treatment (64, 65).
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PMC11566417
For neutrophil reactive oxygen species (ROS) assays, 1 × 10 neutrophils in 100 µL of RPMI isolated from 3 different cows were aliquoted across 4 mL flow cytometry tubes.
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PMC9243326
2013; Roberts et al., 2013; Lin et al., 2017; Ardui et al., 2018; Li et al., 2018; Chen S. et al., 2019; Yang et al., 2020).
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PMC8735881
Similarly, the transduced cells were inoculated with three CXCR4-tropic (NL4-3, SG3.1, and LAI.2) and three CCR5-tropic (RHPA.c/2635, TRJO.c/2851, and MJ4) viruses, and infections were monitored over time by detecting intracellular HIV-1 p24 antigen and GFP expression.
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PMC11337594
Cells were treated with different doses of TER for 48 h, treated cells were digested and prepared into cell suspension and adjusted to the same concentration.
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PMC9429973
In this context, alloreactive NK cells have been correlated with a lower relapse rate, decreasing GvHD with maintenance of beneficial graft-versus-leukaemia (GvL) effect.
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