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PMC11775197
Given that a potential crosstalk mechanism between PPARγ and Wnt/β-catenin regulates CRC progression, this offers a promising avenue for the development of novel PPARγ agonists that inhibit the Wnt/β-catenin signaling pathway .
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PMC10158546
Figure 7.Prion seeding activity within ReN cultures does not surpass residual inoculum throughout 6-weeks post challenge with four prion isolates.
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PMC10965315
Ovarian cancer is one of the most prevalent malignancies in women.
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PMC10507284
ROC curves to predict the sensitivity and specificity of 1‐, 3‐, and 5‐year DSS (n = 257) according to TROAP expression. (
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PMC11402217
Any additional information required to reanalyzes the data reported in this paper is available form the lead contact upon request.
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PMC8998437
They share responsiveness to multiple inflammatory chemokines.
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PMC11684269
Generally, differentiating between adaptive immune responses and innate immune responses on a temporal dimension, it is commonly believed that the early stages of immune response are predominantly characterized by innate immune responses.
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PMC11564405
Several chemokines, such as CXCL9, CXCL10, CCL4, CCL5, CXCL16, and CX3CL1, have been identified as drivers of T cell infiltration .
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PMC9429973
Methods: Patients were followed up until December 2021.
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PMC11637820
The reduced metabolic activity also led to finding increased free bacterial DNA in the supernatant post-CAP treatment.
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PMC11756937
SeV is an RNA virus that infects the cells by binding to the expressed sialic acid residues.
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PMC11637276
a, d, g) RNA sequencing data from PDAC tumours (N = 177) and normal pancreatic tissue (N = 252) for α2 integrin (ITGA2, a), β1 integrin (ITGB1, d), and MAP3K1 (g). ****
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PMC11218145
However, the mechanisms underlying these effects are poorly known.
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PMC10850553
Immunohistochemical analyses investigating cell types expressing C5AR1 in IA lesions.
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PMC9429973
Here we report the results from the first two cohorts of a phase 1 trial of Ven-PegC in adults with R/R AML.
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PMC11522251
B, C Colony formation assays were performed in three cell types after treatment with 100 μg/ml cetuximab. ****
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PMC11409031
As a final step, a clinical prognostic model was developed using a selection of 10 T cell associated genes.
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PMC9429973
Inhibitors of OPN production selected from the in vitro screening were analyzed for their effect on OPN plasma levels in a MF mouse model induced by the treatment with a thrombopoietin receptor agonist Romiplostim (Rom).
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PMC11519077
In this study, we investigated whether the anti-inflammatory, antimicrobial, and antiapoptotic properties of MSCs and their conditioned medium can affect Caco-2 cells as the intestinal inflammatory model, with a vision for ameliorating IBD in the future.
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PMC10993311
Maternal blood collection and biochemical analyses at T1, T2 and T3 were performed by a biomedical specialist in a clinical analysis laboratory in Araraquara city.
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PMC11805741
In addition, their high growth rate and ease of cultivation, and manipulation have made them an ideal source of natural pigments (Ram et al. 2020).
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PMC11023271
The contribution of RNA or DNA in serum was examined by incubating FBS or PBS with 10 μg/ml DNase I or RNase A at room temperature for 30 min prior to administration to cells.
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PMC7229095
We generally switched to richer media for the production after a cell line was established with lean media in the past.
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PMC11640115
Thereafter, based on the finding that ALB alone does not correlate with prognosis, a new term, the “modified GPS (mGPS)”, was proposed by McMillan et al. (2007) .
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PMC11462929
Notably, chromosome 8 amplification including BENC‐CNA was detected in YCUB8, while not in the original primary sample (Figure S5).
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PMC9780037
Packaging of cyt c within gold nanoparticles coated with ionic liquid salts increased cyt c activity and extended its thermal stability and long-term storage .
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PMC7582629
By combing RS and OCT, it is possible to provide a more complete description of the analyzed sample, correlating the biochemical information of the Raman analysis with microstructural and morphological information from the OCT.
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PMC11747467
These results give us confidence in exploring the therapeutic effect of ERBB2-targeting RC48 based on molecular subtypes.
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PMC11297139
Combining an ARID1A inhibitor like BD98 with an inhibitor for EWS/FLI1 could mount a more potent form of therapy for patients.
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PMC11699178
Puromycin-resistant cells were expanded in medium containing 2 μg/mL puromycin for 9 days, then transferred to a puromycin-free medium, resulting in a stable FGFR1-silenced cell line.
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PMC11655498
These two proteins activate other viral lytic genes and eventually induce lytic replication, among which they are involved not only in DNA replication, protein synthesis, and progeny virus production but also operate with various cellular factors-related signaling pathways (Feederle et al., 2000).
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PMC9429973
The mutations were also confirmed by Sanger sequencing.
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PMC9611901
This research represents the first study that applied such an experimental design with the HepG2 cell model and tanning agents.
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PMC9429973
Our model results indicate that a stepwise dose reduction prior to TKI cessation (e.g. 12 month post MR4 at 100% TKI, 12 more months at 50% and 12 more months at 25%) does not limit the overall success rate of TFR, while it substantially reduces the amount of total administered TKI and thereby decreases side effects as well as overall treatment costs.
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PMC7868205
It is believed to be derived from embryonic kidney cells using adenoviral DNA in the 1970s.17 Nanoparticles, especially nanosilver, are known to be toxic to HEK-293 and other cell lines which are considered to be normal.18–20 HeLa is the first immortalised human cervical adenocarcinoma cell line to be cultured in vitro in 1951 and stabilised in 1953 at Johns Hopkins Hospital in Baltimore, Maryland, US.
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PMC11604768
Resulting barcode counts were used to generate estimated transcription rates and analyzed via MPRAnalyze to compare promoter activities between treatments.
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PMC11539788
First, we explored the expression of RNF19A across cancers by analysing sequencing data from various tumours in the TIMER 2.0 database.
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PMC9926039
The results are summarized in Table 1.
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PMC11657744
Cells were fixed and stained with antibodies against PCNA (red), Arl13b (green), and DAPI (blue) for nuclear staining.
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PMC11266100
Images were taken at day 0 (when tumor volume reached 50 mm) and day 14.
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PMC9024365
Selected cells were cropped from the original images, saved blinded and subjected to the analysis by an individual not involved in the cell selection and blinding process.
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PMC3730428
The MPM cell lines also expressed TNFR1 on the cell surface to varying levels (Figure 1b).
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PMC9429973
Relapses occurred in 40% of the patients who received a first-line treatment.
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PMC7987994
Sole MEM with the corresponding concentration of FBS served as a control.
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PMC11637276
Cell media in transfected plates was automatically pipetted and released in a waste reservoir.
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PMC9611901
The most important descriptors of DNA damage are “tail intensity” (the percentage of DNA that has migrated into the comet tail) and “tail length” (the length of DNA migration expressed in μm).
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PMC11543853
With both settings, the total electron exposure was 50 e/Å. Individual images were saved as movies of 4 frames in counting mode.
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PMC11711127
Only certain cells which have a high affinity for superantigens may be anergised by macrophages.
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PMC3813807
The differences among groups were analyzed using the double-sided Student’s t-test, and P<0.05 was used to indicate a statistically significant difference.
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PMC3274243
For example, in Figure 4, differences in the OCP of cytokine, cycloheximide and control RSF cultures can be observed after just four hours from treatment.
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PMC11351758
MitoQ might serve as a remedy in this situation; however, it is not as powerful as CoQ10.
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PMC10671321
As expected, enzymatic activity was increased by four-fold when muscle cells were infected with WT COLQ1a cDNA and six-fold when cells were infected with p.E428HfsX58 ColQ1a.
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PMC11621493
Accordingly, we identified 20:4 LPE and LPC as the most abundant deacylated reaction products (Fig. 2H and L).Fig.
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PMC11703896
The affinity of rapamycin with ROS1 was found to be -7.7 Kcal/mol which indicated that rapamycin is a potent inhibitor of ROS1 inhibitor like positive controls crizotininb (-8.5 Kcal/mol), entrectinib (-9.1 Kcal/mol) and lorlatinib (-9.0 Kcal/mol).
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PMC11530949
This finding aligns with the role of increased ROS levels in guiding cells toward programmed death, and the induction of nanoparticle-induced oxidative stress in cancer cells Flow cytometry plot to assess early apoptosis and necrosis in A) control cells, B) cells treated with the IC50 concentration of Ephedra intermedia extract, and C) cells treated with the IC50 concentration of biogenic Ag-Cu nanoparticles.
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PMC11297139
Ewing’s sarcoma cell line A673 was genetically modified using the CRISPR-CAS9 system.
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PMC11731161
Furthermore, we performed a correlation analysis, which revealed a positive correlation between the protein expression levels of USP7 and XPO1 in MM cell lines (Fig. 5D).
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PMC5308810
Briefly, cells (5x10) were washed twice with cell wash solution.
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PMC9429973
Results: 97 patients (male: 59%; median age: 61 years) received cilta-cel as of July 22, 2021.
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PMC10887351
Particularly, the activation and expression of β3-ARs in stromal and tumors cells of the TME have been shown to stimulate pro-tumoral signaling pathways, which caused tumor progression in different pre-clinical models .
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PMC11747885
Additionally, methylation of the amine group in 42 also resulted in higher cytotoxicity.
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PMC8751435
In our study, it is validated that CME exerted cytotoxicity toward A549 cell line through inducing caspase‐3‐dependent apoptosis and pyroptosis.
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PMC11679326
Lectin iNol-binding monosaccharides and glycoproteins with N-acetylated groups from sleeper lobster Ibacus novemdentatus exerted a cytotoxic effect on breast cancer MCF-7 and T47D cells, cervical cancer HeLa cells, and colorectal adenocarcinoma Caco-2 cells .
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PMC11676670
Short tandem repeat (STR) analysis were performed on the OVAR79 cell line for 19 markers (D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D21S11, CSF1PO, FGA, TH01, TPOX, VWA, D1S1656, D2S441, D10S1248, D12S391, D22S1045, SE33) and amelogenin loci using the COrDIS Plus kit according to the manufacturer’s instructions (Gordiz Ltd., Moscow, Russia).
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PMC11794588
A tricyclic sesquiterpene called cedryl acetate was discovered in the plant Psidium caudatum.
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PMC9429973
Using gene editing to mimic these mutations should reactivate γ- globin in patients with transfusion-dependent β-thalassemia (TDT) and ameliorate the debilitating effects of mutations in β-globin.
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PMC9429973
Results: Totally 46 patients comprising of 23 APL and 23 non-APL AML were enrolled in this study.
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PMC9813422
Viral genomes exhibit remarkable diversity in terms of nucleic acid types, sizes, and complexity.
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PMC9429973
Methods: All pts had Grade (Gr) 1–3a FL and ECOG performance status (PS) 0–1, and were R/R to ≥2 prior therapies, including an anti-CD20 Ab and an alkylating agent.
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PMC11588085
Bubble map of pathways enriched in OVCAR3-KRAB in XIST KD after GSEA.
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PMC11754291
Discrepancies about whether blue light causes photodamage and how keratinocytes and melanocytes interact during melanogenesis highlight the limitations of previous studies.
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PMC11377827
Together, our results highlight the multifunctionality of DUBs, illustrating that they can provide important signalling functions alongside their catalytic roles.
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PMC8140214
The absorbance of the solution was read after 5 min at 412 nm.
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PMC11269933
NGi and NAn represent the C. gigas and C. angulata were reared at northern site.
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PMC9964635
Compound 7a had the most suitable binding poses with a binding energy of −166.843 kcal/mol to protein kinase B. Compound 7a had the most suitable binding poses with a low energy of −166.843 kcal/mol to the catalytic site of protein kinase B. 7a bonded to protein kinase B via H-bonding with Gly164, Phe163, and Thr162, a carbon–hydrogen bond with SerC9, pi-sigma interaction with Gly161, and pi–sulfer interaction with Asp293.
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PMC11574029
C Clonogenic assay evaluating the proliferation ability of T24 and 5637 cells after NOTCH3 knockdown.
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PMC11615101
TNF-α induction upregulates α-Taxilin and inflammation in SW982 synovial cells. (
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PMC11300639
Transwell, CCK-8 and tube formation assays demonstrated that depletion of TSC1 attenuated the effect of RNF26 overexpression on increasing tumor cell migration, proliferation, and angiogenesis (Supplementary Fig. 5b–d).
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PMC11568601
The XBP1 antibody (No. ab220783) was obtained from Abcam Plc. (
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PMC8903741
In this study, we aimed to establish a stable Chinese hamster ovary (CHO) cell line for the stable production of antibodies against hMMP9.
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PMC9429973
Median duration of navitoclax exposure was 9.4 weeks (range 0.1–67.1).
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PMC11562028
Their optimal excitation wavelength is ∼360 nm and the optimal emission wavelength is ∼450 nm (Fig. 1B).
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PMC7823217
However, spheroid models cannot completely recapitulate the cellular and microenvironmental heterogeneity of physiological tumor tissue where spatiotemporal variations in nutrients supplement, cell proliferation and oxygenation often occur.
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PMC11469524
Since the model-based findings rely on a single time point (30min after α-IgM treatment), we investigated the temporal dynamics of MEK and ERK phosphorylation in BL-2 cells (Fig 3A).
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PMC10079526
Interestingly, expression of SUMO E2 enzyme UBC9 significantly correlated to drug synergy, indicating that low expression of UBC9 sensitized the cell lines in our panel for the combination therapy.
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PMC9429973
Relative abundance, overall richness, various diversity indexes were calculated.
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PMC11774251
Statistical significance is indicated as *P <0.05, **P <0.01, ***P <0.001, ****P <0.0001, ns = not significant.
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PMC8633974
Jurkat JLat 8.4 Jurkat T cell line and U1 cell lines were plated at a density of 5x10 cells/well in 12 well plate in RPMI media supplemented with 10% FBS and 1% Pen/Strep for 18 hours before mRNA LNP treatment and maintained at 37°C in a 5% CO2 incubator.
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PMC8592717
Several doses of PCA decreased blood glucose and hemoglobin A1c (HbA1c) due to its antihyperglycemic effects [127-129].
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PMC11434983
The vial was flushed with nitrogen and incubated at 40 °C for 30 min.
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PMC10812665
The top hits indicate alterations in the Warburg effect (glycolysis), the citric acid cycle (mitochondrial function) and AA metabolism (Arg and Pro, Gly and Ser, Asp, Glu).
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PMC11617590
Caspase 3 is a cysteine protease and has a key role in apoptosis .
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PMC11683240
Representative images are shown from three independent experiments (n = 3), D, PTS1 signal is given in the bar graph as x-fold of the PT-treated control (PT), normalized to the Hoechst signal, mean ± SEM (n = 43–45 values from three independent experiments).
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PMC11322866
Scale bar: 10 μm.
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PMC11322866
Briefly, the cells were collected and fixed with 4% paraformaldehyde (Sigma-Aldrich, Darmstadt, Germany) for 15 min.
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PMC11509278
This is the leading cause of death among nonmelanoma skin cancers .
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PMC9429973
Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative strategy for such patients, but incidence of post-transplant relapse is still unacceptably high.
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PMC11547917
Another specie of Aristolochia, A. tagala, presented antioxidant effects when leaves were extracted in a hydroalcoholic solvent system (30.80 µg/mL) .
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PMC10142392
Evidently, several studies have shown that the degree of crystallinity of the copolymers directly influenced their apparent enzymatic degradation and, consequently, their efficiency to inhibit the drug target .
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PMC11106977
To date, an osteolysis diagnosis remains challenging, and the treatments are considered controversial.
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