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OTAR3088
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PMC9621239
Given that the dimerization region and transactivation region of HBx protein was reported to be closely associated with HBx function, the mutation spectrum across the X gene in genotype C and D likely alters the function of HBx protein compared with genotype B. The mutations across the X gene are also likely to be compartmentalized between tumour and non-tumour tissues.
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PMC10728200
I GIST-T1 and 882 cells were treated with IM (50 nM for T1 and 200 nM for 882) for 24 h with or without STUB1 knockdown.
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PMC8708099
Since both HRH1 and NFκB are involved in inflammation, we can speculate that the link between HRH1 and NFκB is physiologically important in inflammation-associated diseases.
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PMC11529598
As expected, the subcutaneous xenografts of the miR-3154 knockdown U251 cells exhibited much higher TP53INP1 levels than their controls (supplementary Fig. 3A).
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PMC10969097
To explore whether GAD could increase the cytotoxicity of cisplatin, the non-toxic concentration of GAD (200 μM for both cell lines) and cisplatin at IC50 values of 40 μM for SKOV3 and 200 μM for SKOV3/DDP were used for 24 h. According to the results, this combination further reduced cell viability in both cell lines, and this inhibitory effect was positively related to the concentration of GAD, demonstrating that GAD potentiated the inhibition of proliferation induced by cisplatin in both cell lines.
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PMC7338939
Our previous experiments indicated that DAPT was less effective on cell proliferation and apoptosis, but its effect on stemness properties such as colony and sphere formation and even stemness-related genes was unclear.
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PMC10955424
Epithelial ovarian cancer (EOC) makes up 90 % of ovarian cancer (OC) cases.
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PMC11471176
In marked contrast, the aggressive breast cancer cell lines, MDA-MB-231 and EMT-6, bore witness to a net antiproliferative impact.
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PMC4112127
For all plates bisulfite-treated CpGenome Universal Methylated DNA (Millipore) was used as a positive control and serially diluted to create standard curves for calculation of copy number of methylated BMP3 and β-actin.
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PMC11769522
In addition, the elevated expression of IFN-γ and TNF-α has also been reported in dogs with AD .
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PMC9429973
Aims: We recently reported the importance of CD9 in pediatric ALL but its role in AML remains unknown.
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PMC11803918
For immunofluorescence staining, the tumor tissue sections were dewaxed in xylene and gradient concentrations of ethanol step by step.
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PMC11155445
In this case, the DBCAW of composites was not affected significantly by the amount of (165), CHP and Cu(acac)2, but a clear trend was observed in the case of DBCAIP.
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PMC10197932
After US treatments, CD3/CD8+ lymphocytes are able to proliferate and differentiate into effector cells when properly stimulated in vitro.
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PMC10723784
Roche buffer was purchased from BD Bioscience, UK, Annexin V‐CF488A was purchased from Santa Cruz Biotechnology, UK.
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PMC11264242
These observations together with the ChIP data suggest that SS18-SSX can bind to the FYN gene locus and repress its transcription in synovial sarcoma cells.
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PMC7305184
Statistically significant difference, with p < 0.05, is observed only at 1500 V/cm between CTRL and EP group of 25 generation (note that first 15 generations are the same as those in experiment 2 from Figs. 2 and 3).Figure 5Scheme of the resistance experiment.
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PMC11731614
All methods involving animals were approved by the IACUC of Northwestern University.
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PMC11612315
The remaining currents between the arrows were CAP-induced currents inhibited by BCTC.
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PMC10850553
Finally, fluorescent images were acquired on a confocal fluorescence microscope system (FV1000 or FV3000, Olympus, Tokyo, Japan).
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PMC11092382
In nonviral liver diseases such as septic liver injury (Zhengyu et al., 2018; Hou et al., 2020) and nonalcoholic steatohepatitis (Song et al., 2011; Song et al., 2013), sophocarpine exerts its liver protective effects through the modulation of key inflammatory cytokines, including IL-6, TNF-α, TGF-β1, and IL-1β.
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PMC11359735
After the transfer, the blot was cut in half to separate the lanes for CSP inositol analysis and immunoblotting.
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PMC9429973
Is the degree of cardiac iron overload consistent with the degree of myocardial injury?
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PMC9429973
The colonies of each hematopoietic cell lines have characteristic morphological features which make it possible to distinguish and count them.
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PMC11788920
All cases are significantly different from the control (P< .01 for all cases).
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PMC9046263
However, several HERVs (mainly HERV-K, subtype HML-2) maintain variable degrees of transcriptional activity that are typically regulated by epigenetic mechanisms, including chromatin remodeling, DNA/histone methylation of transcription factors, and retroviral LTRs.
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PMC11290772
The present study elucidated a groundbreaking approach in the field of immunotherapy, wherein autologous PBMC-derived CAR NK cells targeting ROBO1 were employed for the treatment of ovarian cancer.
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PMC10421378
In general, three strategies can be distinguished: adding protective agents, optimizing drying parameters, and prestressing the probiotic cells before drying .
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PMC9688728
In conformity with several prolonged studies performed on cell lines, we ignored desynchronization in changing the nutrient medium and fixing changes in the metabolome.
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PMC11627060
The addition of 0.16 mL of 8% glutaraldehyde facilitates cross-linking with BSA NPs.
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PMC8526701
Our results demonstrated that the level of BRD9 was highly increased in GIST specimens, and correlated with the increased size of the tumor.
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PMC11627060
Consistent with free TQ treatment, the TQ-BSA NP-exposed cancer cell line displayed a concentration-dependent response in terms of cellular morphology.
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PMC11551844
A whitish color observed with HT-29 cells indicated toxicity.
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PMC11334037
These pathways, regulate the proliferation rate and apoptosis of cancer cells.
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PMC10854447
Structures of previously reported compounds 6a–o and newly synthesised 7a–o. Motivated by previous findings and in pursuit of a new antiproliferative agent with dual or multi-targeted inhibitory action, we present here the design, synthesis, and antiproliferative activity of a novel series of 1,2,3-triazole/1,2,4-oxadiazole hybrids (7a–o, Figure 2) as dual EGFR/VEGFR-2 inhibitors.
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PMC11796104
Osteoporosis is a kind of chronic systemic skeletal disorder with the feature of reduced bone mass, deterioration of the microstructure of the bone tissue and increased fragility, caused by a broken balance between bone formation and bone resorption .
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PMC11684269
Through these mechanisms, itaconate impedes Th17 differentiation while potentiating Treg differentiation (69) ( Figure 1 ).
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PMC8633974
Seven of 10 possible off-target regions for TatDE fell in intronic regions, whereas only 2 of 10 for LTR-1/GagD were noncoding.
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PMC10587429
For studies where percentage of mice with lung metastasis was analyzed, Fisher’s Exact test was used.
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PMC11522251
Cell viability was evaluated by MTT analysis.
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PMC11653168
These results indicated that Stattic may effectively inhibit STAT3 activation in a dose-dependent manner in both CCRF-CEM and Jurkat cells.
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PMC9429973
Based on current data there have been no observed dose limiting toxicities in cohort 1 of QW oral SEL 40 and 60 mg with RUX.
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PMC11750161
This mutation resulted in completely impaired cAMP responsiveness, as shown in Figs. 4 and 5 and Table 2.
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PMC10213199
The product was validated using an Agilent Technologies 2100 Bioanalyzer for quality control.
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PMC9429973
In functional studies, both PIs continued to block chymotrypsin-like proteasome activity in resistant cells.
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PMC9693627
After elution fractions contained PTCD2 were combined and dialyzed against 4 changes of 25 mM sodium phosphate buffer pH 7.5, 150 mM NaCl for 24 h. Protein concentration was measured by Coomassie Protein Assay (Thermo Fisher Scientific, Waltham, MA, USA).
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PMC11402217
Divergent from agents like methotrexate, XD23 maintains bone integrity by modulating the Wnt/β-catenin pathway, presenting a benefit in averting tumor-associated bone deterioration.
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PMC11640419
OA is a common constituent of numerous foods and plant materials and is also an indispensable component of the human diet .
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PMC11790971
Ablation studies were conducted to compare the classification performance with and without EM-ILR.
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PMC11742431
Thereafter, the fluorescence intensity of different cells at various time was also analyzed by flow cytometry (Figure 3D–F).
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PMC10178190
Thus, there is no correlation between ERK1/2 phosphorylation and platinum sensitivity in OC cells exposed to CM derived from TA HS-5 versus ERK1/2 correlating with platinum chemoresistance in OC cells grown in direct co-culture with MSCs .
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PMC11764090
On one hand, transcription factors A. thaliana AtMYB15 , Musa nana MpMYBS3 , and O. sativa OsMYBS3 are inhibitors of cold signals by inhibiting the expression of CBF genes under cold stress.
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PMC11599565
However, detecting E-Cadherin with commercial antibodies often reveals bands at different molecular weights, depending on the cell type and its physiological state.
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PMC6835428
A second factor involves the possibility of targeting siRNA to OC cells.
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PMC8382973
To determine the peptide inhibitor dose corresponding to the 50% inhibitory concentration (IC50) with a confidence interval of 95%, a piecewise linear dose–response curve was constructed for each virus type.
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PMC11400680
The most popular FNC model for semantic segmentation is U-Net (14), which arranges layers in a U-shaped structure.
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PMC11095939
Protein-bound DNA was amplified by qPCR.
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PMC11138140
However, the average starting optical volumes of the norepinephrine-treated cardiomyocytes were significantly decreased compared to that in the untreated control cells (Figures 1D and 2D).
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PMC8358006
The libraries were sequenced by Illumina HiSeq X Ten Sequencer.
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PMC9429973
The age ranged from 24 days to 8 years.
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PMC11697189
Independent prognostic factors including risk score, age, grade, AJCC stage were selected to construct nomogram predicting the probability of survival at 1, 3, and 5 years (Fig. 5D).
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PMC11225860
The second cell reenters G1 becoming red at 11 hours.
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PMC7961460
Hyaluronan is a main glycosaminoglycan in extracellular matrix with an important role in breast cancer progression.
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PMC11496728
Intracellular genomic DNA was also extracted.
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PMC9429973
A total of 33pts died: 23 from infection, 10 from other complications directly related to aGVHD.
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PMC10956161
The sections were pretreated with 10% normal goat serum at 37°C for 60 min.
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PMC11269933
The monomeric form of PKM2 can further translocate to the nucleus and act as a histone kinase, upregulating the expression of c-Myc and cyclin D1, ultimately promoting the Warburg effect (cancer cells preferentially utilize glycolysis to produce energy even in aerobic environments, thereby promoting tumor growth and proliferation) and cell cycle progression, respectively.
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PMC11047729
β-Lapachone is a substance found in the heartwood of the lapacho tree (Handroanthus impetiginosus).
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PMC11345828
The diastereomeric mixture of atropisomers 33 was separated by reverse phase HPLC (Phenomenex Gemini C18, H2O/CH3CN gradient from 50% to 95% CH3CN for 10 min, 0.1% TFA) to afford ∼40% of each atropisomer.
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PMC9503669
The antiretroviral activity of the top-scoring hydroxypyrazole Nef inhibitor analogs were then assessed in HIV-infected peripheral blood mononuclear cells (PBMCs) from uninfected donors.
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PMC9479186
Mitochondria play an important role in cell metabolism, and mitochondrial oxidative phosphorylation complexes are essential for the production of adenosine triphosphate (ATP) (4).
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PMC9429973
Although it has been shown that oncogenic NUP98-fusion proteins act as transcriptional regulators, it is unclear if and how NUP98-KDM5A directly regulates gene expression to drive leukemia.
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PMC10523483
Moreover, knocking down KEAP1 in A427 cells (KEAP1 WT) also up-regulated GCLC expression, and rescued ROS accumulation in cells lacking H1.2 (SI Appendix, Fig. S7 A–C).
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PMC11365983
Normal iris anatomy for comparison (green box).
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PMC7342409
Based on the natural evolution of the disease, the patient could be placed on a higher dose of imatinib or a tyrosine kinase inhibitor such as ripretinib, though resistance can be a challenge.6–8 Resistance to imatinib has been of great interest in recent research.
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PMC8623816
These results also demonstrated that both the viral particles and dsRNAs extracted from the mycelia of strain D122 belong to the same mycovirus, RsRV5.
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PMC10810426
Positive cells with spots in nucleus, nuclear membrane, or cytoplasm were normalized to the number of cells in the pictures.
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PMC11186948
Experiments were assayed in biological and technical triplicates and HDAC2 or TP53 levels were quantified relatively to the expression of three housekeeping genes (GAPDH, RPLP0, RPL13A) using a comparative Ct quantification method.
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PMC11757131
Currently, 3-HIB has been confirmed to regulate fatty acid transport and promotes cell proliferation in human and mouse skeletal muscle cells (12, 13), as well as in porcine intestinal epithelial cells (8).
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PMC9429973
Chi square test and Fisher exact test was applied to observe the association.
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PMC11718817
We cannot prove that tracking arrests are, in fact, causally linked to cytotoxic effector function.
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PMC7823217
C. (a) Drug dose response of glioblastoma cells in 3D bioprinted models.
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PMC11680578
Percentage cell survival after 24 h treatment of 1 nM, 5 nM, 10 nM, 25 nM, 50 nM and 100 nM PTX. (
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PMC9027909
Comparisons were carried out using the Student’s t-test.
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PMC9429973
After completion of the safety run-in, additional pts will be enrolled in cohort 1 (n=40), cohort 2 (n=30), and cohort 3 (n=40) for phase 2.
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PMC10568263
As seen in Fig. 9(a), the diameter of the semicircle increased as the concentration of HSP70 antigen increased within the range of 0.001–1000 ng mL, and it also indicated that the ΔRct-value increased.
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PMC11506827
The terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay confirmed that GEF amplified TRAIL-induced DNA fragmentation in 786-O and A498 cells.
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PMC11354239
and specific intron-spanning primers (Table 2 below).
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PMC9429973
Partial response was established in 62,5% cases.
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PMC11640419
Furthermore, the p21 protein functions as an anti-apoptotic protein by inhibiting the cell cycle.
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PMC7757104
Accordingly, drug adaptation and thus, resistance, are considered to be a dose-dependent condition for certain drug classes and in vitro models.
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PMC10170482
Alexander and HepG2 cells were cultivated for 7 days in either MC or CS conditions, stained with 1 μM JC-1, and treated with different depolarizing agents.
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PMC10890307
This was independent of the presence of glucose or lactate.
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PMC11412721
Levels of p53-α and p53-AS transcripts and p53 protein levels in lymph node tumors. (
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PMC6379402
The next research steps include other groups reproducing these findings and extending them towards further validations that are necessary to confirm their specific roles in cancer.
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PMC10079526
We evaluated the role of MYC overexpression by knocking down MYC expression in P493-6 Burkitt lymphoma cells.
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PMC11025866
Entry of EBV into cells does not use xCT.
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PMC9429973
AML patients under treatment-free observation in CR could be expected to have a vaccine effect that is comparable to that in healthy individuals.
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PMC11753435
β-Catenin binding activity determined by ELISA with immobilized β-catenin.
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PMC8270637
However, the clones of SMMC-7721 cells co-cultured with activated T cells stimulated by TGF-β1 have a tendency to restore round, complete shape ( Figure S4 ).
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