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PMC9429973
The CRi rate was highest with VEN+HMA (20%; 95% CI, 12%-33%; N=54), followed by IC (6%; 95% CI, 1%-20%; N=35).
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PMC11746948
Furthermore, APT2-deficient cells demonstrated resistance to other ferroptosis inducers, including ML162, ML210, and erastin (Supplementary Fig. 9d).Fig.
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PMC9429973
REGN5458 is a BCMAxCD3 bispecific antibody currently under investigation in relapsed/refractory MM (RRMM) in an ongoing Phase 1/2 trial (NCT03761108).
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PMC11792766
No. T3125), and dioxane (Supelco, Cat.
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PMC9429973
Only patients (pts) with diagnostic confirmation via histopathologic examination were included.
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PMC11467800
The invasiveness/metastasis and angiogenic potential assays were performed using fluorescence microscopy (Olympus IX71).
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PMC10040136
Silencing of the TGF-β receptor and PI3K-AKT inhibitor antagonized this effect (A–D).
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PMC9429973
Aims: We explore the effect of flumatinib combined with Bcl-2 inhibitor on cell proliferation arrest and apoptosis in SUP-B15 human Ph+ B-cell ALL cells.
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PMC11767793
The stability tests of the commercially sourced particles in FBS-DMEM (Figure S6g–i) showed similar trends to the AuNPs@NIST.
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PMC9429973
N. Y. Semenova, N. I. Enukashvily, I. I. Kostorma, L. A. Belik, D. V. Baram, V. A. Balashova, S. V. Gritsaev, S. S. Bessmeltsev, D. I. Ostromyshenskii, I. S. Martynkevich Russian research institute hematology and transfusiology; Institute of Cytology, Russian Academy of Sciences, Saint-Petersburg, Russia Background: It has been increasingly recognized that cancer progression is not an autonomous process driven and performed exclusively by cancer cells.
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PMC8728081
Fig. 2 Physicochemical characterization of Kajjali and Rasasindura.
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PMC11092382
The same results were obtained in another study carried out by Lu et al., who similarly evaluated the protective effect of sophocarpine in a mouse model change and additionally discovered sophocarpine decreased myeloperoxidase (MPO) activity and malondialdehyde (MDA) content.
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PMC9429973
However, given the scarcity of case reports, further studies are needed to establish the relationship between allogeneic HSCT and the presence of ischemic events in CNS.
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PMC7351993
We denote the numbers of the sorted and unsorted particles in the collection fluid as NPMMA, collection and NPS, collection, respectively, and those in the waste fluid as NPMMA, waste and NPS, waste, respectively.
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PMC9429973
Aims: CITADEL-112 (NCT03424122) is an open-label phase 1 study evaluating the safety and tolerability of adding parsaclisib to investigator choice SoC Tmt rituximab (RIT), RIT + bendamustine (BEN), or ibrutinib (IBR) in patients (pts) with R/R B-cell lymphoma.
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PMC11727062
Melanoma is a highly aggressive cancer, prone to metastasis, and primarily affects the skin and mucous membranes.
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PMC11612794
The cell cycle gates were manually adjusted based on plots of CENP-C/CENP-T cells, clearly distinguishing between subG1, G1, S, and G2/M populations, which were then applied to other cell lines.
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PMC10529414
Additionally, RUNX proteins form functional complexes with other proteins to activate and repress the transcription of key regulators associated with cell growth and differentiation, demonstrating a dual function of members of this family .
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PMC10545062
A sealed-envelope system was used to randomly assign treatment groups at T0, ensuring no knowledge of the animal’s eventual group assignment would have an impact on animal instrumentation prior to start of computer-automated protocolized injury.
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PMC10213199
Larvae2315742389High conc.
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PMC11756937
The advantage of the episomal approach is that compared to viral methods, the construction and production of the plasmid are relatively simple .
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PMC9429973
Three DLTs occurred in 2 patients during the study and comprised Grade 3 and 4 transaminase elevations; one each at 4.2 and 10 mg/kg and one Grade 3 thrombocytopenia at 4.2 mg/kg.
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PMC9429973
However, AA and PGF samples exhibited upregulation of CD163 compared to NC (AA_DX adj P = 4.5e-6; AA_PROG adj P = 1.2e-5; PGF adj P = 1.58e-8) suggesting an increase in monocyte/macrophage lineage cells.
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PMC11587541
Thus, only 10–20% of normal SMN protein comes from the SMN2 gene which is not able to compensate the loss caused due the deletion of SMN1 gene .
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PMC11388384
Under this model, the gaps between adjacent cells, even at submicron scale, would impose diffusion barriers for membrane-associated Hedgehog molecules.
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PMC11438317
A HEK293 cells were transiently transfected with 3xHA-LP-DACS along with expression plasmids of SKAP2 wild type and mutated to Phe in the Tyr indicated.
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PMC11653533
In folk medication, boiled steam bark of the plant is utilized in the treatment of sore throat, scrofula, respiratory and chest maladies, sore, boils, peptic ulcers, jaundice, vaginal or butt-centric infections as well as fungal infections of the gut (Erhirhie et al., 2018, Maregesi et al., 2007), whereas the decoction of stem bark used in gastrointestinal tract issues, diabetic complications, infertility, low sperm count, human sterility, breast milk production, excessive menstrual and sometimes in the treatment of cancer (Erhirhie et al., 2018, Dluya et al., 2015).
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PMC11442172
In addition, these TIFM-cultured PDAC models revealed high de novo arginine synthesis activity to be a specific metabolic feature of PDAC tumors (46).
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PMC8978939
Also, 786-0 cell line was injected as an internal control for the experiments.
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PMC11472569
EVs deliver their contents to elicit phenotypic and functional changes in recipient cells through three main mechanisms: (1) Direct activation of target cells via interactions between surface ligands on the EVs and receptors on the target cells; (2) Transfer of activated receptors; and (3) Genetic reprogramming through the delivery and translation of mRNAs or post-translational modifications.
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PMC11352311
For example, caffeic acid has been shown to be a potent antitumor agent, effectively inhibiting liver, breast, and skin cancer .
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PMC8193813
While not necessarily obviating the need for CEM for regulatory compliance, the use of UAS-based measurements could provide a safe and fast method of checking emissions that does not require personnel and equipment to access elevated stacks for periodic CEM verification.
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PMC5330095
After incubation with 5% CO2 atmosphere at 37°C for 16–24 h, the confluent monolayer of HepG2 2.2.15 cells was washed and the medium was replaced with complete medium containing test compounds at a single concentration of 10 µM. Three days later, the culture medium was replaced with fresh medium and test compounds at a single concentration of 10 µM. Six days following the initial administration of the test compounds, the cell culture supernatant was collected, treated with pronase and DNAse, and then used in a real-time quantitative TaqMan PCR assay.
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PMC7887261
c Representative flow histograms showing higher γH2AX levels in gene knockdowns.
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PMC11774112
The CMC of Co-PHRD was as low as 0.002131 mg/mL, suggesting that the PHRD micelles are stable within the body following intravenous injection.
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PMC11731161
Cells were fixed with 4% paraformaldehyde phosphate buffer solution (Beyotime, China) for 15 min.
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PMC11774251
Principal Component Analysis (PCA) plot showing the distribution of samples from NC (non-treated), CON (TNF-α-treated), and Tan-I (TNF-α and Tan-I-treated) groups. (
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PMC11670954
Average relative immunofluorescence intensity of MLCK. (
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PMC7757104
Notably, the number of ACRP cells was decreased in response to OPNc silencing compared with that of the ASO SCR-transfected cells (Fig. 2E).
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PMC11640555
MTT assay findings from this study demonstrated that CK2 inhibition avoids GBM cell proliferation, a result that is complemented by the colony formation assay showing that CX-4945 strongly suppresses the colony growth of glioma U-87 cells in a concentration-dependent manner.
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PMC11707832
Misfolded mutations: These mutations lead to the synthesis of proteins with structural misfolding, preventing them from attaining the correct folded configuration.
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PMC9429973
References 1.
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PMC11753949
Based on public gene expression databases (e.g. https://tabula-sapiens-portal.ds.czbiohub.org), synaptopodin 2 and synaptopodin 2-like have a similar expression pattern as synaptopodin in human brain, but are mainly absent from mouse neurons.
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PMC8711270
Of these, six are cell and gene therapies (Mullard, 2016, Mullard, 2017; Mullard, 2018; Mullard, 2019; Mullard, 2020; Mullard, 2021) where the HEK293 cell line or its derivatives were used in the production of viral vectors.
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PMC9429973
Summary/Conclusion: Our data showed that: ATG dose of 6 mg/kg group was associated with a similar proportion of GVHD, Viral infections, relapse, and (OS) as 5 mg/kg ATG.Hower,the incidence rates of relapse in 16mg ATG-F patients higher than 6mg ATG group, but similar with ATG dose of 5mg group.
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PMC10993311
This finding may be explained by a compensatory mechanism at the end of the last gestational trimester.
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PMC10958426
Heatmap of CNV level in reference normal cells and cancer cells, with rows and columns representing cells and genomic loci, respectively. (
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PMC11095939
We transiently transfected NIH3T3 cells with Mecp2 or Nedd4 siRNA (Genema, Shanghai, China) using Lipofectamine 3000 in Opti-MEM medium, according to the manufacturer’s instructions.
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PMC11365427
Data are shown as mean ± SEM; an unpaired two-sided t-test was applied.
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PMC11794568
For nonparametric tests, the two-tailed Mann-Whitney test was used to assess statistical significance between two groups.
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PMC11454387
First, we generated a triple negative breast cancer cell line MDA-MB 231 stably expressing a H6PD-biotin ligase fusion protein.
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PMC11706491
D, E) Quantification of the different cell cycle phases.
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PMC11515150
Eleven days after tumor engraftment, a single of 5 × 10 CAR-NK cells or NK cells was injected into each mouse intravenously.
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PMC11388384
Notably, the size of the gradient measured by the extracellular SHH-Halo particles is slightly smaller than the gradient measured by the SHH signaling reporter (~50 µm vs ~100 µm).
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PMC9429973
MajesTEC-1 is an open-label, multicohort, phase 1/2 study evaluating teclistamab in patients (pts) with relapsed/ refractory multiple myeloma (RRMM) previously treated with ≥3 prior lines of therapy (LOT).
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PMC10547921
The dihydrobenzofuran compound 64 was highly toxic in primary CLL cells and opening the furan ring also maintained low nanomolar activity in primary CLL cells and JN-3 cell lines.
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PMC11720107
Previous studies have shown that aged garlic extract increased ROS production in human neuroblastoma SH-SY5Y cells, but when co-treated with 6-hydroxydopamine (6-OHDA), ROS production was reduced .
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PMC11344246
Therefore, to date, there has been no MOC-specific protein-protein network published.
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PMC9429973
Most patients (54%) received an antibiotic at least once during follow-up; overall, use of immunosuppressive therapy (2%) or iron chelation (3%) was rare.
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PMC9429973
Cytogenetic findings were obtained in different pts: KMT2A rearrangement, hyperdiploidy, del(IGH), complex karyotype, trisomy of chromosome 10.
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PMC11201989
Together, these results suggest that PD-L1-mediated PC-2 ciliary accumulation may be caused by a defective IFT-associated mechanism.
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PMC11672881
Cells were treated with 10 µM CM-H2DCFDA in cell culture medium without FBS at 37 °C for 40 min, followed by three washes with phosphate-buffered saline (PBS).
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PMC11742290
WNT proteins activate two major intracellular pathways, canonical and non-canonical signaling pathways .
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PMC7090062
Also, we collected samples from 10 patients and analyzed the miR-30a level in GISTs and normal adjacent tissues.
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PMC9429973
A. M. Zeidan, A. Al-Kali, U. Borate, T. Cluzeau, A. E. DeZern, J. Esteve, A. Giagounidis, K. Kobata, R. Lyons, U. Platzbecker, D. A. Sallman, V. Santini, G. F. Sanz, M. A. Sekeres, A. H. Wei, Z. Xiao, M. Van Hoef, C. Nourry-Boulot, I. Sadek, F. Ma, A. Iordan, J. Sabo, G. Garcia-Manero Yale University and Yale Cancer Center, New Haven; Mayo Clinic, Rochester; Oregon Health & Science University, Portland, United States of America; Centre Hospitalier Universitaire de Nice, Nice, France; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, Baltimore, United States of America; Hospital Clinic, Barcelona, Spain; Marien Hospital, Düsseldorf, Germany; None, Los Angeles; The US Oncology Network, San Antonio, United States of America; University Hospital Leipzig, Leipzig, Germany; H. Lee Moffitt Cancer Center & Research Institute, Tampa, United States of America; University of Florence, Florence, Italy; Hospital Universitari i Politécnic La Fe; and CIBERONC, Instituto de Salud Carlos III, Valencia; Madrid, Spain; Sylvester Comprehensive Cancer Center, University of Miami, Miami, United States of America; Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia; Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China; Novartis Pharma AG, Basel, Switzerland; Novartis Pharmaceuticals Corporation, East Hanover; MD Anderson Cancer Center, Houston, United States of America Background: Patients (pts) with higher-risk myelodysplastic syndromes (HR-MDS) unfit for hematopoietic stem cell transplant (HSCT) have poor outcomes with single-agent hypomethylating agent (HMA) therapy.
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PMC11740508
were from SelleckChem®.
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PMC7294030
Aurisin A is a promising anticancer agent for use against human lung cancer.
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PMC9504875
Cell lysates were separated by SDS-PAGE, transferred to a nitrocellulose membrane, and analyzed by the western blot (WB) technique.
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PMC11763111
Consistent with these findings, CD38 knockdown in our study may help inhibit CAR-T cell fratricide while simultaneously augmenting CAR-T cell antitumor activity.
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PMC11700340
This interaction governs the breakdown of ATP and triggers the start of the Hsp90 molecular chaperone cycle, which supplies energy for cellular processes; Hsp90 and Hsp90 have a role in regulating the folding of proteins in mitochondria.
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PMC10196713
Flow cytometric analysis was performed using BD LSRFortessaTM X-20 (BD Biosciences).
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PMC11697065
Forkhead Box O3 (FOXO3), SPRY domain containing 3 (SPRYD3), FGFR1OP2, Clcn4, Arhgap33, and Tmem104 were all more abundant in high qP clones.
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PMC11144382
Interestingly, CRABP2 expression has been reported to be upregulated through the RA pathway, while VCAM1 appears to be an indirect target of the RA pathway in a permissive cellular context.
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PMC11283030
e. Kaplan–Meier plotter revealed RFS of 361 ccRCC patients with follow-up, according to ACLY mRNA expression.
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PMC9429973
The data from the published literature demonstrate that 40–60% of patients achieve TFR, with relapses risk occurring within the first six months, almost all patients who relapsed regained a molecular response upon retreatment, indicating TKI discontinuation is safe.
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PMC8316344
NS non-significance; ***P < 0.001; ****P < 0.0001.
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PMC9429973
Univariable and multivariable regression models were used to identify potential prognostic factors to adjust for in the ITCs.
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PMC5386478
TG2 activity was determined by pre-incubating cells, cultured in 2D or as spheroids, with 1 mM 5-biotinamido-pentylamine, a competitive amine substrate of TG2, for 2 or 24 h at 37 °C.
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PMC11377827
n = 3, biologically independent samples, mean ± sd.
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PMC10454535
In studying the effects of RES derivatives on MM cell viability, as well as assessing synergism between RES-derivative PIN and the already implemented drug BTZ, we learned more about the drugs’ cytotoxic efficacies and possible MM-targeting mechanisms.
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PMC9895440
For the remaining cells (n = 3405 intergenic and n = 3612 Snx9 KO), a FeatureScore for cell cycle genes (S phase and G2M phase), histone genes and interferon-stimulated genes together with the number of unique features per cell were used to scale the data (ScaleData).
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PMC10419319
Then, different concentrations of cisplatin and/or isoalantolactone were added to each well.
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PMC9587298
In the co-incubation treatment the same concentrations were tested, elderberry extract solutions were prepared in FBS-culture medium containing 3 mM MGO, cells were co-incubated for 24 h. The same procedures were performed in HepG2 cells, with the same concentrations of elderberry extracts, but with 2 mM of MGO (as explained in results section).
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PMC10604092
A study has suggested that the levels of NGAL in the blood are correlated with obesity, insulin resistance, hyperglycemia, coronary heart disease, acute kidney injury, and fatty liver .
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PMC8922418
However, although PE has a broader range of applications and more accurate edits, the editing efficiency of it is lower than that of BE.
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PMC10671321
Indeed, there is some confusion about the role of the CTD in the literature.
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PMC9325715
Thus, using Molegro Molecular Viewer 7 all particles of water and cofactors were removed.
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PMC11794847
T cells play a pivotal role in the adaptive immune response and have become central to the success of immunotherapeutic strategies, particularly in the context of cancer treatment .
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PMC11345828
Plasma samples were obtained at predefined time points and compound concentrations in plasma were measured by quantitative HPLC-MS/MS using an internal standard.
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PMC11155445
The synthesized acyl thiourea (44) not only showed better antiurease activity compared to thiourea but also this compound was more potent than complexes of corresponding acyl thiourea.
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PMC11727638
Tables S1 and S2 present the mean fluorescence intensities of 2D cultured cells immunostained without anti-CD19 or anti-CD20 and with anti-CD19 or anti-CD20, and those of Cell Dome cultured and high-density Cell Dome cultured cells immunostained with anti-CD19 and anti-CD20.
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PMC9672323
As shown in Fig. 4, dexamethasone limited the cell cycle progression by significantly increasing the fraction of PBMCs in G0/G1, while the accumulation of cells in the S and G2/M were decreased (Fig. 4, Table 5s, p = 0.047 in G0/G1, p = 0.015 in S, and p = 0.034 in G2/M).
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PMC11792090
Notably, X-C motif chemokine ligand 1 and 2 (XCL1 and XCL2), which play a role in leukocyte activation (42, 43), were significantly elevated in SAP UCAR-T cells.
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PMC11406030
There was a significant increase in caspase-3 activity when ovarian cancer cells were treated with 10 μg/mL of LMTK3BP #1 and #2 (Figure 4B), suggesting an apoptosis-dependent mechanism.
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PMC10047551
We note the expected positive correlation between PD-L1 mRNA expression and PD-L1 TPS (r = 0.64, p = 0.0003) (Figure S6D).
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PMC8864075
AKT phosphorylation level = p-AKT band/AKT band.
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PMC11791432
Fig. 6G and H presented consistent results.
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PMC9429973
In the R/R Ph+ ALL cohort, the 2-year EFS rate was 42% and the 2-year OS rate was 61%.
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PMC11594641
These results provide further evidence that Rab27A and Rab27B do not affect the number of sEVs secreted by the A375 cells but significantly change their protein content.
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PMC8609870
Some reports have revealed that AQP1 plays an important role in acute lung injury caused by endotoxic shock, delaying the occurrence of renal cyst, and acute lung and brain injury .
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