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PMC11577421
Two major binding modes were detected with an estimated KD in the sub-nM range and koff rate constants in the range from 3 × 10 to 2 × 10 s. These low koff values imply that NP_BSA+ remained strongly bound to the surface during the dissociation phase, possibly due to avidity effects (a single coated NP binding to multiple heparin molecules).
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PMC9429973
Aims: To investigate how HDT/ASCT treatment influences the risk of developing congestive heart failure in a population-based nationwide setting.
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PMC9398137
The BCL2 protein expression status in individual cell lines as analyzed by Western blotting correlated with the BCL2 protein expression positivity assessed by IHC analysis of the cell line–derived xenografts or PDX models.
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PMC11718109
EM images of striatal agarose blocks immunogold-labeled (dark particles) with synaptophysin (D), HA-VMAT2 (E) and synapsin (F).
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PMC6889484
Overall, these results indicated that CD4 T cell lines expressing A3G-D128K were capable of long-term HIV-1 inhibition without detectable emergence of A3G-D128K-resistant virus.
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PMC11488203
While unique miR expression can be related to individual properties of certain MSC further analysis was performed regarding the 594 commonly expressed miRs.
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PMC11277157
We anticipate that each cell displays a unique collection of genes to cope with oxidation, rendering a cell-specific capacity for coping with oxidative stress .
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PMC9429973
The TriKE also induced specific NK cell proliferation.
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PMC3019555
However, the pathways regulated by interphase microtubule dynamics in epithelial cancer biology are poorly understood.
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PMC9429973
Recent studies have investigated novel venetoclax-based combination regimens to further improve anti-leukemia efficacy, evade drug resistance, reduce toxicities, and promote deep durable remissions.
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PMC7759933
The HepG2 spheroids were formed by the forced floating method from an initial cell density of 6000 and 3000 cells/spheroid.
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PMC6892818
Bars show mean fold change of 5–6 technical replicates ± SEM.
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PMC7229095
The most complicated media in CLD are the cloning media for single cell isolation.
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PMC11674441
These results indicate the immunological efficacy of the HLA class II-restricted neoantigen peptide dendritic cell vaccine against breast cancer.
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PMC11092382
Similarly, Liu et al. evaluated the impact of sophocarpine on endothelial apoptosis by isolating rat aortas and culturing rat aortic endothelial cells.
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PMC10237474
The puromycin and hygromycin kill curves were plotted and the lowest drug concentration that killed 100% of un-transfected host cells, but not transfected cells, was chosen as the antibiotic selection concentration.
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PMC8777939
One study reported that the incidence of neoplastic lesions diminished in antiretroviral therapy (ART) recipients, such as Kaposi’s sarcoma patients , non-Hodgkin’s lymphoma patients , and women with cervical cancer who are living with human immunodeficiency virus (HIV) .
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PMC10965680
Then, “GenotypeGVCFs” and “SelectVariants” were used to call potential SNPs from the combined GVCF files.
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PMC10810426
This may be because the nucleocapsid is more dissociated from PICs found in NIH3T3 nuclei than in DCs.
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PMC11759543
Symbols ∗ and # were compared with control and Z-IETD-FMK only, respectively. (
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PMC9429973
Summary/Conclusion: Our data are in line with published studies, and confirm the poor outcome of post-transplant relapse.
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PMC11670954
Relative mRNA expression of ROCK2. (
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PMC11033180
Neurons were depolarized by 1 min exposure to 90 mM KCl and collected for western blot analysis and assessment of synapsin 1 phosphorylation at site Ser-603, Ser-9 and Ser-62/67.
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PMC11604768
c Dose response curve from HEK293 cells transfected with an AR promoter dual luciferase reporter and treated with dexamethasone (AR, minCMV, rotation 4, spacer set 1).
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PMC9622879
A CEMS generally includes two parts: energy management for its DERs and energy trading for its members.
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PMC8348645
Test for Glycosides: We mixed 0.2 mL of sample with 0.2 mL of chloroform.
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PMC10582049
The analysis of bulk RNAseq dataset obtained from TCGA demonstrated that high expression of the ADH1B CAF markers is associated with lower enrichment of infiltrating immune cells, and reduced expression of different types of collagens and upregulated expression of DCN, LAMA2, and ELN that is consistent with the results obtained using scRNAseq and histological assessment of LUAD samples from our cohort.
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PMC11653533
2013, Patel and Gautam, 2014, Talukdar et al., 2015).
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PMC11770746
Therapeutic interventions for CIPN are very limited since no drug is recommended for CIPN prevention; currently, only duloxetine is recommended for CIPN treatment (moderate recommendation by American Society of Clinical Oncology (ASCO)).
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PMC10040136
The data were analyzed by t-test or ANOVA to determine the statistical significance.
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PMC11322866
EZH2 is degraded via the ubiquitin-proteasome pathway .
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PMC9874064
Data are expressed in mean ​± ​SD from n independent experiments (n ​= ​3).
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PMC6835428
Finally, another potential targeting antigen is represented by CD24, highly expressed in many cancers with a percent positivity in OC of about 70% .
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PMC9429973
The most frequent CNA were gains of 1q (39.3%), 6p (28.6%) and 3q (27.3%); and losses of 9p21.3 (CDKN2A/B) (39.3%), and 7q31-q32 (33.3%).
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PMC10452486
Davies’s team has clarified that the oxidative crosslinking may result in the folding of HCs within the ER or Golgi involving the generation of S-S bonds or even dityrosyl linkages to promote the dimerization of Face-2.
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PMC11222184
Fig. 2Heatmap of gene expression profiles of SH-SY5Y cells treated with XL-888 and Debio0932 Heatmap of gene expression profiles of SH-SY5Y cells treated with XL-888 and Debio0932 The administration of HSP90 inhibitors XL-888 and Debio0932 to neuroblastoma cells resulted in a decrease in the expression of angiogenesis-related genes, including ANGPT1, ANGPT2, FGF2, KDR, TEK, VEGFC, and SERPINF1 .
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PMC11449273
Plakoglobin (PG) interactions with the three forms of p53 were also confirmed by GST pull-down assays.
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PMC11521786
In this regard, the selected adjuvants (VSSP and Montanide) could provide the immune system with the “danger” signals necessary for activating DCs, polarizing toward a Th1 response, and stimulating specific CD8 T cells (40).
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PMC11612508
SEM micrographs of the pattern of (A, B) Fe3O4 magnetic NPs at two magnifications (C) TEM image of Fe3O4 magnetic NPs and (D) SEM of GO nanostructures.
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PMC9429973
Summary/Conclusion: In our cohort, median PFS and OS after SAT was 78 mo and 28 mo, respectively.
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PMC11621565
Following that the cells were detached with a cell scraper in RIPA cell lysis buffer with a 1% fresh protease inhibitor cocktail (Halt Protease Inhibitor Cocktail 78,429, Thermo Scientific).
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PMC11116779
After 24 h, 10, 100, and 500 μg/mL of PS-NPs were added to cells, which were further incubated.
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PMC11648299
Exposure to heat and sun were most often reported as disease triggers.
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PMC11604768
Transcription factor binding to the response elements activates the minimal promoter, initiating transcription.
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PMC11453018
C The Venn diagram of DEGs in three ES cell lines following EWS::FLI1 knockdown reveals both common and unique DEGs across the cell lines .
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PMC9318744
Using ACE2plusC3 cells, researchers can now examine additional attachment factors and their contributions to susceptibility to virus infection.
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PMC11725127
In addition, we found that the protein levels of USP2 were higher in primary myeloma cells and myeloma cell lines than in normal peripheral blood mononuclear cells (PBMCs) (Fig. 6I) and normal bone marrow biopsies (Fig. 6J).
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PMC9872547
The IC50 value was observed at very high concentrations (about 160 μM, Figure 1A2).
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PMC10900886
We observed differences in the susceptibility and permissiveness to EV-D68 infection among viruses or donors included in this study.
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PMC6835428
Finally, we discussed the most interesting works published in the last three years about polymer-/lipid-based materials for siRNA delivery.
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PMC11257988
Adeegbe et al. improved the response of KRAS-mutant NSCLC to immune therapy by combining JQl (a BET family inhibitor containing a bromodomain) with anti-PD-1 treatment.
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PMC4485786
Importantly, the senescence-resistant sarcomas did not express the cell cycle regulator p16 (not shown), confirming that senescence induced by IFN-γ and TNF strictly required the activation of p16.
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PMC11394112
NOD.Cg-Prkdc Il2rg Tg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ (NSG-SGM3) Mice (JAX stock #013062) and NOD.Cg-Prkdc Il2rg/SzJ (NSG) Mice (JAX stock# 005557) were procured from Jackson Laboratory.
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PMC11698348
Skin and hair development is regulated by multitude of programs of activation and silencing of gene expression to maintain normal skin and hair follicle (HF) development, homeostasis, and cycling.
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PMC11049548
Being A2780 among the most popular cell line models for ovarian cancer, here we would like to highlight metabolomic similarities and differences with primary cells of HGSOC, which, indeed, represent the most common histological type of ovarian cancer.
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PMC10040136
Additionally, secondary mutations occurring in KIT/PDGFRA have been linked with secondary resistance [6–8].
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PMC11180402
D SNHG1 expression in 5637 (vector) vs. 5637 (SNHG1) cells.
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PMC9429973
4.-The relationship with the referral hospital and transfusion center seems to be the most important predisposing factor to maintain a certification program.
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PMC9509578
Dual drug delivery via nanoparticle systems was also developed in which combinations of drugs are co-delivered to cells, and the presence of one drug enhances the bioavailability of another drug .
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PMC9118379
If yes, the identified variant peptide is not reliable.
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PMC11790971
To provide more details of different cell line distributions, single-cell SLAM composite images corresponding to the dots in the t-SNE plots were sampled and visualized in the same location for all three passages (Fig. 3d–f).
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PMC11697065
However, the dominant feature associated with higher protein production was transgene copy number and the resulting mRNA expression level.
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PMC9429973
The next step in this project is to gather a focus group and gain more in-depth qualitative data.
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PMC9985266
In contrast, RT‒qPCR and Western blotting showed that DNMT1 expression was significantly elevated after TGF-β1 induction, while IL-27 treatment reversed the TGF-β1-induced DNMT1 elevation (Fig. 5C, D).
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PMC11320834
The kinetics of drug release from liposomes were determined using DDSolver software by fitting the obtained results to different kinetic models: Higuchi, Krosmeyer-Peppas, and Peppas-Sahlin .
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PMC11678130
In brief, 400 cells/well were cultured in 6-well plates and left to adhere to the plate.
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PMC10958426
Volcano plot of DEGs between tumor subclones in each patient.
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PMC11621493
Statistically significant differences are shown as: ∗, #P < 0.05; ∗∗, ###P < 0.01; and ∗∗∗, ###P < 0.001.
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PMC11541241
TOR forms a proteinaceous complex with its primary interactors to exert its function (Figure 1b).
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PMC6102174
H. elliptica (Tuoyuanye Huamao) within the Gentianaceae family is an annual herb widely distributed in Southwest, Northwest and North China.
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PMC9429973
A. Cili, E. Petrela, A. Zaka, A. Hatellari, P. Pulluqi, T. Caja, A. Perolla, E. Calliku, M. Kreka, E. Dollaku, X. Ngjela, A. Memini, A. Kaleci, A. Ivanaj Service of Hematology; Universitary Hospital Centre “ Mother Teresa”, Tirana; Lushnja Hospital, Lushnje; Durres Hospital, Durres; University of Medicine, Tirana Albania, Tirana; Fier Hospital, Fier; Vlora Hospital, Vlore; Kavaja Hospital, Kavaje; Novartis Pharma Services Inc, Albania, Tirana, Albania Background: SCD is a group of inherited disorders affecting hemoglobin (Hb) synthesis.
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PMC11697703
Interestingly, ENCODE identifies enhancers and promoter sequences in this region (Figure 1B).
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PMC10944868
In this context, it is noteworthy to emphasize that among the range of compounds evaluated, the one that stands out for exhibiting the most intense and sustained interaction with the protein is compound 12E (Table 3, entry 12).
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PMC11026382
This indicated that the model provided a specific description of our experiment and was not trivially overfit.
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PMC8567602
C, The fractional abundances of BAF subtypes calculated by optical densitometry–quantified gradients of SMARCC1 overlaid onto the normal distributions of PBAF, CBAF, and GBAF defined by PBRM1, DPF2, and BRD9, respectively, in synovial sarcoma and control cell lines.
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PMC11525028
Dose–response curves were generated using GraphPad Prism (v8) with a log (inhibitor) versus response fitting.
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PMC9596868
We further wanted to understand the mechanism behind increased DNA damage upon combination treatment with MST-312 and quercetin.
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PMC10092581
We hence evaluated the effect determined by treatment with selenourea complexes in terms of modification of mitochondrial pathophysiological characteristics, such as mitochondrial membrane potential and morphological changes, and induction of cell death through apoptosis.
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PMC11695623
B,C) The difference of DCUN1D5 expression in TCGA-LUAD dataset. (
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PMC9429973
Feces samples of healthy controls were chosen to match the CLL population with respect to age, demographic data, sample collection method, and sequencing platform.
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PMC11486946
Colored curves correspond to the indicated EGF concentrations.
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PMC9429973
Aims: To evaluate the efficacy, safety, and tolerability of magrolimab+AZA vs physician’s choice of VEN+AZA or “7 + 3” chemotherapy in patients with previously untreated TP53m AML.
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PMC10747160
However, this attenuation was mild when compared with Griffithsin’s prophylactic activity against other viruses, indicating that Griffithsin might dictate its prophylactic activity against SARS-CoV-2 via disrupting a process other than viral spike interaction with the hACE2 receptor .
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PMC9822769
The area of the chromatographic peaks of the Pt complexes was monitored in HPLC-MS, using a 70 : 30 mixture of 15 mM aqueous HCOOH and CH3OH as the mobile phase (see Section 2.3, settings i), for further instrumental details).
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PMC11539788
RNF19A mRNA expression in BCa with different lymphatic metastasis statuses, as determined from the UALCAN database. (
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PMC9429973
Aims: We aimed to assess the activity and safety of ibrutinib in a cohort of patients with CLL aged ≥80 years at therapy start.
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PMC11747885
To monitor the ligase activity by fluorescence, the RNA is subjected to denaturation by the addition of ethylendiaminetetraacetic acid (EDTA), resulting in single stranded oligonucleotides.
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PMC10936243
Even if they defaecate, we will just clean it, unless there are babies” [D073]. “
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PMC8956657
B Quantitation of the nuclear to cytoplasmic fluorescence signal (Fn/c) was measured in 88 cells for the wild-type protein, 85 cells for the R24A mutant protein; 139 cells for the R33A mutant protein; 118 cells for the R24A/R33A; 121 cells for the RKRA mutant protein; and 60 cells for the delta38 truncated protein, with error bars indicating mean values ± standard deviation.
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PMC11377827
PHD3: control vs USP43 siRNA **P = 0.0095, control vs. 14-3-3 siRNA **P = 0.0039.
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PMC11471176
Moreover, it unveils the modulatory impact of this ACE2 inhibitor in breast cancer cell lines.
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PMC9429973
Results: We built a model including 9 simple predictors, including the initial PLT count, age, age at onset, infection, ITP type, skin and mucosa bleeding, low PLT count (below 20*10), uncontrolled diabetes, and cardiovascular disease.
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PMC11348300
Unlike traditional methods that rely on blood oxygen or tissue perfusion, PRESTO leverages the intracellular location of PpIX, a product of cellular mitochondria metabolism, offering a unique perspective on tissue oxygenation.
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PMC9424261
We further added ferroptosis inducer and CA to detect how the ubiquitination of GSS changes in liver cancer cells.
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PMC9429973
Refractory ITP patients show an increased tendency of platelet desialylation, whereas its impact on bleeding phenotype and thrombosis incidence is not completely elucidated yet.
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PMC11441402
SK-MEL-2 melanoma cells after 48 h treatment with 1 nM portimine, probed with Hoechst-33342 and SYTOX green.
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PMC10606998
A statistically significant effect of radiosensitization by nanoparticles was observed in both cell lines when cells were exposed to 35 keV X-rays.
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PMC7153288
A total of 7205 genes was predicted in the genome of Streptomyces sp. SS1-1 by the NCBI Prokaryotic Genome Annotation Pipeline.
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PMC11502443
Web of bias plot of ΔΔlog (τ/KA) values for the E354Q GIP receptor, where the reference peptide is GIP(1-42) and the reference pathway cAMP.
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PMC11732628
In addition, miR-490-3p was found to bind to NUSAP1, and negatively regulate NUSAP1 expression.
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