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PMC9220170
The results of this work are consistent with the previously revealed dependence of a decrease in AMFR and RNF5 mRNA expression on a decrease in SELENOT mRNA expression .
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PMC11476837
In order to measure the production of intracellular ROS, the fluorescence of H2DCFDA was measured.
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PMC11786600
Immunofluorescence staining was performed utilizing different antibodies, and sections were incubated with rabbit anti-rat primary antibodies (MMP9, TNF-α, IL-1β, IL-6, IL-10, CD31, VEGF, CD86, CD206) and goat anti-rabbit secondary antibodies, respectively.12,30 Finally, fluorescent images captured by confocal microscopy were analyzed and illustrated and analyzed using the ImageJ software.
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PMC11707577
Data represent the mean ±SD of three technical repeats from two biological replicates (n = 15).
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PMC2614416
BLAST searches were carried out with BLASTP 2.2.13 [Nov-27-2005].
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PMC11116779
In our study, PS-NPs induced dose-dependent lung cell apoptosis, as revealed by FACS analysis.
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PMC9473868
BAI treatment significantly upregulated epithelial markers of E-cadherin in a dose-dependent manner compared with controls, whereas it dose-dependently downregulated epithelial markers of vimentin, snail, MMP2, and MMP9 (Figures 4(c)–4(e)).
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PMC9429973
P. Strati, L. Leslie, P. Shiraz, E. Budde, O. O. Oluwole, M. Ulrickson, A. Ramakrishnan, J. Sun, R. Shen, J. Kanska, P. McCroskery, J. Dong, M. Schupp, H. Xu, K. Patel The University of Texas MD Anderson Cancer Center, Houston, TX; John Theurer Cancer Center, Hackensack, NJ; Stanford University, Stanford, CA; City of Hope National Medical Center, Duarte, CA; Vanderbilt University Cancer Center, Nashville, TN; Banner MD Anderson Cancer Center, Gilbert, Arizona; Texas Transplant Physician Group, Austin, TX; Kite, a Gilead Company, Santa Monica, CA; Swedish Cancer Institute, Seattle, WA, United States of America Background: Despite the success of axi-cel, ≈60% of patients have no response or relapse within ~2 y after treatment (Jacobson C, et al. ASH 2021. #
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PMC11306331
Lines show individual cells with the average shown in bold.
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PMC8592717
It also restored oxidative stress-induced inactivation of the Akt pathway and suppressed excessive H2O2-induced DJ-1 oxidation in SH-SY5Y cells .
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PMC11694625
Therefore, verification tests for NDEA and NDMA are necessary.
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PMC11281366
Our results reveal significant alterations in miRNA and mRNA expression profiles in infected relative to uninfected cells.
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PMC11389534
It is noteworthy that UFMylation of RPL26 has been shown to enhance the translation of hepatitis A virus in human hepatocytes.
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PMC10093184
In spite the absence of colonies formation in semisolid medium, both cell lines further possess unchanged ability of adherent growth on plastic surface under standard cultivation condition and therefore we are convinced, that they fulfill all requirements for being designated as osteosarcoma cell lines.
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PMC9429973
We analyzed: the efficiency of the procedure, the volume of collected product and the final count of CD34+ collected.
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PMC11715644
We wondered whether such accumulation of cell density near narrower confinement would also depend on cellular properties, specifically those regulating the cohesion of the epithelial population.
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PMC8270637
After blocking, the membranes were incubated with the following antibodies: GAPDH (1:10,000), lamin B (1:1,000), PD-1 (1:1,000), CTLA-4 (1:200), NFATc1 (1:1,000), and p-NFATc1 (1:10,000).
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PMC9424261
Primary liver cancer is the third leading cause of cancer death in the world, and the lack of effective treatments is the main reason for the high mortality.
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PMC11033180
Strikingly, the ASD-associated mutation S956G in Sema5A strongly affected these activities.
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PMC10125312
Discrepancies between studies highlight the importance of studying cytotoxicity for different cell types, tissues, and nanoparticles individually, almost erasing the possibility of extrapolating results.
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PMC11055443
Cholera toxin as the main virulent factor of V. cholerae, mediates enzymatic activation of adenylate cyclase and increases cAMP which terminates dehydration through diarrhea (1).
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PMC11621565
The CI values registered every 30 min were normalized and processed using RTCA Software 2.
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PMC11204465
Compound 66 showed strong antimicrobial activity against Bacillus cereus with a MIC value of 38.3 µM and weak inhibitory activity against Fusarium oxysporum .
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PMC11422497
Subsequently, the synthesis of complementary DNA (cDNA) was performed using the PrimeScript™ RT-PCR Kit following the manufacturer’s protocol.
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PMC11609529
Notably, regulators such as SREBF2, E2F3, TRIM24, NKX2-3, MYC, FOXM1, and YAP1 were inhibited, whereas STAT1, IRF7, PML, and IRF1 were activated, as determined by a Z score above 3 and a p value below 0.05.
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PMC11731614
Of the 33 differentially expressed microRNAs with a fold change (FC) ≥ 1.5 (adjusted p-value ≤ 0.05) between RD and HFD, 22 were overexpressed in HFD.
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PMC9895440
The cells generated with this approach acquire features of T cells in human tumors, such as co-expression of inhibitory receptors, reduced effector functions, and impaired proliferation, a phenotype recently also observed with continuously stimulated CAR T cells.
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PMC11453018
C Kaplan-Meier survival curves reveal significant differences in survival outcomes between the two patient groups identified through NMF clustering.
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PMC11401358
However, whether SF has a potential function in alleviating ROS and the related mechanism is still elusive .
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PMC11438317
After PV treatment for 5 min, cells were lysed, and LP-DACS was immunoprecipitated with HA Ab bound to Sepharose beads.
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PMC9429973
Targeting diverse regions of SARS-CoV-2 increases the reliability of the results and makes it possible to identify the virus strain.
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PMC11047729
Tocotrienol and tocopherol belong to the vitamin E group.
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PMC11476106
Moreover, we detected a slight increase in cluster density with time of culture (median = 0.028 clusters/nm at 2 weeks vs. median = 0.0325 clusters/nm at 3 weeks in HGs without added VN, and median = 0.0215 clusters/nm at 2 weeks vs. median = 0.0234 clusters/nm at 3 weeks in HGs with added VN).
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PMC9429973
The patients received standard six cycles of BR regimen as induction therapy, and then received lenalidomide (10mg, qd) maintenance vs. no maintenance, from December 2020 to February 2022.
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PMC11321678
Single‐cell chromatin landscape of human medulloblastoma A) Schematic representation of the samples used in this study (n = 11), sequencing experiments, and downstream bioinformatic analyses.
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PMC11746948
once every three days).
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PMC10745221
al , was diluted in 2X sample buffer, and 6.5 μg were loaded onto the gel.
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PMC11487720
The inner membrane of the bubble is from the nucleus, and the outer membrane is from the cell membrane .
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PMC8524093
However, it is still unknown whether infection of epithelial cells exert any other effect in the pathogenesis than just an internal virus reservoir.
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PMC11612794
Thus, in our model, both CENP-T and Dsn1 phosphorylation may contribute to the CENP-T-Mis12C interaction in early mitosis (Figure S7D).
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PMC9386809
Also, the cone conformation in 2 provides an open face for the reactions to occur, while the coordinating nitrogens help stabilize the metal center.
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PMC11098378
Further studies will be needed to confirm Ceg10 function and its regulation by S-nitrosylation, however, these data suggest that a putative cysteine protease encoded by L. pneumophila is capable of targeting antiviral immune pathways in insect cells.
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PMC5600151
Furthermore, superior therapeutic response over the existing treatments is expected to justify the advancement of such nanoformulations.
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PMC6892818
Induction of TRAF1 was also evident in HRPT cells, although this response was slower (observed after 6 h) and less-pronounced when compared to RCC cells (Fig. 5a).Fig.
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PMC11401350
Administrating a monoclonal antibody (immunotherapy) specific for this receptor or peptide will eliminate the CAR T cells.
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PMC9429973
In patients treated with KRD, the ORR was 74% (n=51), with 42 % CR (n=29),p 0,31.
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PMC9429973
Resulting gene expression was characterized by changes in interferon-responsive genes and inflammation-associated transcription (Fig 1c).
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PMC11547917
In the scientific literature, the antioxidant assays employed were total phenolic content, flavonoid content, reducing power, ferrous metal ions chelating, superoxide anion, hydroxyl radical, hydrogen peroxide, and nitric oxide .
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PMC10125312
Nanoparticle toxicity together with cellular uptake can provide a lot of information regarding cellular resistance to nanoparticles and their materials.
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PMC11534035
Filling a notable gap in the available literature, in this study we set out to uncover what effect the level of PAI1 had on VSCC cell lines.
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PMC10728200
E Western blot analysis of GPX4 in GIST-T1 and 882 cells with GPX4 overexpression.
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PMC9739791
Based on the combined evidence, the photoreduction mechanism of Phorbiplatin 8 was proposed (Figure 5).
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PMC10840195
We hypothesized that the Wnt/β-catenin signaling pathway and EMT cross-talk enhanced tumor drug resistance.
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PMC8143558
In the light of COVID-19, soap and hand hygiene have taken center stage.
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PMC11791264
F, SKOV3 cells stably expressing pCDH or pCDH-SETD7 were transfected with MYC-LC3B WT or K51M mutant followed by a Transwell assay for 24 h. Left panels show the representative images of migrated cells, and the right panels show the quantification of migrated cells (200 × magnification).
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PMC11222184
In this study, the effect of XL-888 and Debio0932 HSP90 inhibitor on SH-SY5Y neuroblastoma cells was comprehensively evaluated.
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PMC10808409
After 10 min, the % of FA released from the optimized mixed micelles (O1) and the TPGS mixed micelles (O2) were 12.00 ± 2.11% and 25.57 ± 2.52%, respectively, whereas only 8.65 ± 1.55% was released from the standard.
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PMC11644761
The “Cell Cycle Hypothesis” is a recent theory proposed to explain the pathogenesis of AD.
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PMC10551595
Based on the preceding evidence, it is plausible to assert that GinA may be categorized as an inducer of apoptosis as opposed to an initiator of necrosis.
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PMC9712534
In contrast, the nuclear mobility of TOP2B H58Y was remarkably low (Fig. 2).
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PMC9429973
Similar rates of positive laboratory test results were reported in the two age-groups.
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PMC11697703
Within the electroporated S1-area, layer II-III neurons expressing both miRs-193b and -365 showed reduced MAPK8 somatic signal compared to adjacent non-electroporated neurons.
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PMC9429973
Baseline characteristics are shown in Table 1.
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PMC11711127
Perforation of the mitochondrial membrane is regulated by the B-cell lymphoma-2 (Bcl-2) protein family.
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PMC7351993
The 3D acoustic focuser meets this purpose.
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PMC11544122
For experiments with Cmp101, cells were pre-treated with veh (DMSO) or Cmpd 101 (final 30 µM) for 30 mins at 37 °C before the addition of CXCL12.
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PMC8348645
Quantification of the results was accomplished by measuring the optical density of the bands, using the computerized imaging program Image J. The values were normalized to β-actin intensity levels.
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PMC11224020
e, Box plots showing the minimum to maximum range in log scale of the number of migratory DCs in Arpin and Arpin (N = 3 independent experiments, where each dot is one mouse).
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PMC8540692
Thus, we wanted to analyze if CCM and NaBu are able to reactivate RUNX3, SFRP1, and RASSF1A gene expression and if this change in expression is accompanied by DNA promoter demetylation.
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PMC11711127
It would be interesting to explore what contact tolDCs—DCs which are semi-mature and ‘professionally’ tolerogenic—form with T cells.
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PMC11307990
In this study, we utilized 6HB-DONs as the framework cores of DNA nanotapes, which possess a length of 380 nm and a linear structure.
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PMC10671321
They are responsible for the structure of the protein in the triple helix and the association of COLQ with acetylcholinesterase.
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PMC11806106
Further data analysis was performed with GraphPad Prism 7 (GraphPad Software), as described before.
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PMC11574271
Similarly, J82 cells were transfected with the RON Lentiviral vector or the corresponding empty lentiviral vector to establish stable cell lines with overexpressed RON (designated as J82-NC and J82-oeRON, respectively).
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PMC11528603
B: HL60 cells treated with doxorubicin (0.1 μg/ml) for 24 hours.
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PMC9844987
Training and test data were defined as for the CNN and Random Forest models.
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PMC11604768
To test these findings in an orthogonal assay, we derived dual-luciferase reporter plasmids containing individual promoters controlling the expression of a luc2P CDS, as well as a constitutive SV40-driven Renilla luciferase cassette.
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PMC11335267
Representative MRI axial planes used for quantification corresponding to the abdominal region. *
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PMC9429973
Age- and gender-matched United States life table hazards were used in projections for LTS and to ensure modeled hazards were not less than the general population.
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PMC11483468
P<0.01.
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PMC11190062
Each dot represents cells from one individual patient.
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PMC10547921
In the in vitro cell activity assay, its IC50 falls into the picomolar range, demonstrating its strong ability to inhibit tumor cell proliferation.
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PMC11727062
These mechanisms include the inhibition of cell proliferation, induction of apoptosis, suppression of cell metastasis, and reversal of drug resistance.
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PMC11476837
Doxorubicin itself did not increase ROS level in HL-60/DR cells.
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PMC9847912
While there is an extensive body of literature regarding the activity of maturation inhibitors against HIV-1, only a few studies have examined the activity of maturation inhibitors against HIV-2.
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PMC2614416
In fact, they are subdivided into 22 classes, based on the type of biochemical reaction pathway they catalyze .
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PMC11529598
p < 0.05.
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PMC11317131
The full Bxb1 attP site and minimal attB site (22,54) were substituted for the PhiC31 att sites in the AP and CP respectively (Supplementary Table S4).
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PMC9429973
Summary/Conclusion: These data indicate that both C3-S/F and CR1 density polymorphisms may influence C3b loading on PNH-E, with C3 fragments influencing EVH risk.
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PMC11665584
Comparing the transcriptomes of the human acute wounds to published datasets of human and murine keratinocytes, a small subset of genes unique to oral keratinocytes and virtually absent in skin keratinocytes was identified and included the transcription factors SOX2 and PITX1.
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PMC11803210
The criteria for identifying differentially expressed genes (DEG) included |log2(fold change)| ≥ 1 and adjusted p-value < 0.05, yielding 40 upregulated genes and 11 downregulated genes in the Nar-treated group normalized to DMSO control (Fig. 1B, C).
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PMC11591038
Hypoxia downregulated the expression of IDE, another peptidase known to degrade Aβ, in U87 glioma cells , but the potential roles of HIF-1α remain unclear.
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PMC9429973
The median age was 52 years (range 29-65 yrs.),
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PMC9429973
Image: Summary/Conclusion: Understanding the role of T cell composition on therapy response may offer novel approaches for both predicting prognosis as well as developing new therapeutic strategies.
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PMC11723947
P values were calculated using unpaired t test (two-tailed).
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PMC9454178
Both THZ1 and imatinib treatment led to c-KIT expression inhibition, and the combination treatment enhanced the inhibition of c-KIT expression and the downstream AKT and ERK signalling pathways.
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PMC11723947
The weighted correlation network analysis of the genes overexpressed in HP1γ-deficient Tconv compared with wild-type Tconv in the presence of Treg identified four clusters with different expression patterns (Fig. 6a).
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PMC9429973
Median follow-up time was 1.7 months (IQR: 0.6‒3.4) from the date of PTLD diagnosis.
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PMC11783017
C–E) Secretion levels of pro-inflammatory cytokines (TNF-α, IL-6 and IFN-γ) in serum. (
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PMC11583690
As shown in Fig. 3A, MSN (black line) has a broad peak at 3437 cm, which corresponds to the stretching vibration of surface O–H bonds because of water adsorption on the nanomaterial's surface or silanol groups .
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