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PMC11525028
In colon cancer, NAT10 and ac4C modification were reported to regulate the proliferation and metastasis of tumor cells, facilitating malignant progression.
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PMC11300639
It has been reported that the combined use of CDK4/6 inhibitors and mTOR inhibitors can provide greater benefits to patients in the treatment of breast cancer .
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PMC11297139
It is noteworthy that ARID1A is presented with a high rate of somatic mutations in many diseases, contributing to the accumulation of a significant number of mutations in its PrLDs.
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PMC9429973
The UMG2 expression profile on peripheral blood cells from healthy donors and on a panel of cortical T-ALL cells has been evaluated.
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PMC11753435
Samples were treated in independent biological replicates (n = 2).
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PMC5716223
Protein extraction and immunoblotting was performed by standard methodology as already described .
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PMC9429973
151 (36%) patients had an event of relapse (n=51 patients, 12%) or refractory disease (n=100, 24%).
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PMC10810426
Additional studies are also necessary to determine if MLV CA physically binds to multiple nucleoporins, and if MLV interaction with nucleoporins affects nucleocytoplasmic trafficking, or also affects MLV’s access to the host chromatin and chromosomal site selection for integration.
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PMC9429973
Use of JAK inhibitors might have significantly improved the outcome of patients with constitutional symptoms.
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PMC11409031
The research examined the relationship between the risk score of the model and various clinical traits.
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PMC11704834
The Cell Fractionation Kit (cat.
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PMC11577421
Details are available in the Supporting Information.
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PMC5600151
Kesharwani and co-workers investigated the encapsulation of melphalan in PPI dendrimers of different generations and after surface modification .
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PMC10938336
Lastly, ethyl 2-benzylidene-3-oxobutanoate exhibited a binding affinity of −6.48 kcal/mol, forming hydrogen bond interactions with Phe A96 and Leu A97 residues of CASP3 (Figure 8).
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PMC11354239
To stimulate the CD16-mediated activation of NK cells, we incubated them with the target Burkitt lymphoma cell line Raji, pre-coated with the anti-CD20 therapeutic monoclonal antibody RTX.
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PMC11590005
Sum-score in the ‘affirmation of differences’ domain was higher among male students (PR = 1.138 95% CI 1.019- 1.271 p = 0.022) than among females.
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PMC11544122
No. 60004-1-Ig), anti-GRK2 (cat.
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PMC11470999
Mass spectrometry analysis identified that CIP2A is in the specific band, with the highest scores and top abundance (Figure 3D and Table S1).
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PMC7961460
Statistically significant values of p are reported in the figure legends.
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PMC11746942
A Macroscopic appearance of dorsal skin (top row), skin-draining lymph nodes (middle row), and histological staining (H&E) of the back skin of WT mice and S1PR3-KO mice with and without IMQ treatment.
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PMC10582049
On the other hand, we identified increased expression of ELN, LAMA2, and DCN in ADH1B CAFs.
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PMC11739484
Furthermore, our study uncovered potential regulatory mechanisms involving miRNAs and immune modulators, shedding light on the intricate molecular pathways underlying MMP-mediated tumorigenesis and immune evasion in SKCM.
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PMC11395280
In this mouse, the PRDM14 locus has been cloned downstream from the loxP-STOP-loxP cassette, within a ROSA26 promoter.
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PMC11129910
The primary epithelial cell lines were immortalized by transducing them with LXSN CDK4 R24C—a mutant form that cannot be inhibited by p16 INK4A—followed by transduction with hTERT, the catalytic subunit of the telomerase enzyme.
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PMC8701144
Finally, we demonstrated that siRNA-mediated reduction of E1B-55k protein levels lead to a dispersal of the cytoplasmic bodies and that HEK293 cells with reduced E1B-55k protein levels display reduced WNT/β-catenin transcriptional activation upon stimulation with Wnt3A.
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PMC10729469
The TCRAb were developed from disease-specific T cell effector (Teff) clones.
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PMC10317042
The values shown are relative to the input.
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PMC11413393
Upon addition of dox, we observed strong depletion of PRMT1 at day 3 and day 6 in both RCC243PRMT1-shRNA and 786-0PRMT1-shRNA cells (Fig. 3a).
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PMC11247842
Enrichment of significant variants from the single-trait meta-analysis and multi-trait meta-analysis in genomic features identified from a previous study .
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PMC11562028
Fluo-4-AM was used to detect changes in the intracellular Ca concentration of the A498 after 48 h of co-incubation with different concentrations (0, 30, 50, 70, and 90 μg mL) of the Re-CDs.
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PMC11698348
However, additional studies are required to determine its application.
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PMC11637284
Thus, these four p166 C-tail binding sites cannot be physiologically relevant as in vivo they are not accessible for binding to the IMS-exposed C-tail of p166 (Fig 2B).
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PMC9503685
AMPs are bioactive small molecules that are found in organisms ranging from prokaryotes to humans and take part in the first line of defense against a broad range of pathogens.
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PMC11803149
P values <0.05 were considered as statistically significant.
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PMC7039683
We similarly engineered two GFP reporter constructs from 700 bp elements centered on SNP1 with risk or non-risk alleles of it.
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PMC11400680
Figure 7 is a graphical representation showing the distribution of mean IoU, mAP50, and mAP50–95 values.
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PMC2011198
In admixture, the 2 antibodies displayed synergism in their cytotoxicity although this was only demonstrable with defined ranges of antibody concentration.
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PMC9436459
The key steps towards the target molecule included a hydrogen-bond-assisted Diels–Alder cycloaddition to build the cyclohexene unit, and a selective cleavage of the ortho-methyl ether of the resulting cycloadduct to allow the C3–C21 bond rotation for intramolecular cyclization of the oxabicyclic [3.3.1] core .
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PMC10158546
Cells were collected with a cell scraper in PBS, pelleted and washed 3× in PBS, re-suspended in 100 µL PBS with protease inhibitor, and sonicated via 2 × 30 s bursts at low intensity.
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PMC9776316
Here we identify XRCC4 as a critical factor to confer cisplatin resistance in ovarian cancer.
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PMC11627133
As expected, AS1411‐RhoBAST retained RhoBAST's high affinity to SpyRho (K D=92±3 nM) and a large fluorescence turn‐on ratio of (37±3)‐fold (Figure S3D, Table S1).
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PMC11320084
Cells in the upper chamber of the transwell were erased with a cotton swab, and cells were observed under a microscope and counted.
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PMC11258145
Isotherms of surface tension (π) versus area per molecule (A) for monolayers prepared from DPPC; DOPC; Chol; and model cells membranes SK-N-SH and HL-60 mixture with curcumin (at a different molar ratio) on the surface of 0.01 M phosphate buffer, pH 7.4.
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PMC9429973
Aims: To verify the efficacy of rhTPO in children ITP and to explore the effects of THPO SNPs (rs6141 and rs956732) and MPL SNP (rs176067 and rs190983971) on the efficacy of rhTPO, in order to find predictive factors for rhTPO.
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PMC11621565
Real-time monitoring of dopaminergic-differentiated SH-SY5Y cells under treatment was assessed by measuring cellular impedance using the xCELLigence platform (Agilent Technologies, Santa Clara, CA, USA).
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PMC10996034
The TS P-values of POLR3GL, ZNF239, FLRT3 and ZFHX4 were 0.66, 0.35, 0.35 and 0.28, respectively (Figs. S2 and S3).
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PMC11351758
We concluded that NARP-induced F1F0-ATPase inhibition augments mitochondrial toxicity, especially in the presence of Ca and high glucose.
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PMC9429973
Summary/Conclusion: DLI has been widely applied to the therapeutic intervention, with promising results in prevention and preemptive strategy.
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PMC10890055
Generally, the extracts prepared in MEM were more toxic for the hFOB 1.19 cell line compared to the extract prepared in DMEM/Ham’s F-12, even when they contained less Zn.
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PMC11786600
a–e) Contact angle images of the dynamic variation for PED0 (a), PED1 (b), PED2 (c), PED3 (d), and PED4 (e). (
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PMC10849234
Promyelocytic cell lines therefore offer an attractive option for in vitro studies of neutrophil degranulation .
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PMC9429973
With a median follow-up of 14.4 months, 136 subjects (20.4%) required at least one dose reduction due to adverse events; 309 patients (46.4%) had their dose decreased in the absence of any evidence of side effects.
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PMC11790971
However, including all cells from these passages significantly enhanced classification performance, underscoring the impact of sample size on results (Fig. 2d–f).
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PMC11521786
Although this hypothesis needs further demonstration, it suggests the feasibility of combining HER3 as an antigen with other HER receptors (specifically oncogenic receptors HER1 and HER2) in the context of multivalent vaccines.
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PMC11349530
This can be achieved by focusing on the reduction of tumor cell IRFs production capabilities.
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PMC7433824
Dissolved samples were centrifuged (10 000 g, 30 minutes) and 2D Quant kit (GE Healthcare Life Sciences) was used for protein concentration assessment.
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PMC3765139
This could not be confirmed in our experiments.
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PMC11743414
The apoptosis of cells treated with different concentrations of Ara-C (A) and DNR (B) was detected under the silenced and overexpressed FHL1.Under the treatment of 100 nM Ara-C, the percentage of apoptosis cells ofsilenced FHL1 increased by 2.42% compared with the cells of overexpressing FHL1.Under the treatment of 200 nM Ara-C, the percentage of apoptosis cells ofsilenced FHL1 increased by 10.97% compared with the cells of overexpressing FHL1.Under the treatment of 500 nMAra-C, the percentage of apoptosis cells ofsilenced FHL1 increased by 18.52% compared with the cells of overexpressing FHL1.Under the treatment of 0.2nM DNR, the percentage of apoptosis cells ofsilenced FHL1 increased by 2.07% compared with the cells of overexpressing FHL1.Under the treatment of 1nM DNR, the percentage of apoptosis cells ofsilenced FHL1 increased by 2.66% compared with the cells of overexpressing FHL1.Under the treatment of 2nM DNR, the percentage of apoptosis cells ofsilenced FHL1 increased by 8.55% compared with the cells of overexpressing FHL1 A FHL1 gene differential expression was analyzed in 337 whole blood RNA sequencing data from Genotype-Tissue Expressionand 379 acute myeloid leukemia samples.
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PMC6364197
The application of 3D cell culture system enables researchers to create superior in vitro models to obtain more realistic physiological results from studies in vitro.
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PMC8584319
AZD8055 and refametinib were procured from Cayman Chemical (Ann Arbor, MI, USA).
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PMC11788920
Furthermore, we demonstrate that whether the target sequence of dCas9 is in the template strand (TS) or nontemplate strand (NTS) of transcription is critical not only because of the resulting modulation in GQ stability but also because of the different levels of blockade CRISPR–dCas9 presents for the RNAP in these cases.
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PMC11779993
Based on our present findings, SPEE was found to contain the highest amount of flavonoids, which was consistent with previous research on Sargassum polycystum .
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PMC9429973
Thus, for further in vivo studies, we used rabbit human IgG1 chimeric mAbs that cross-react with murine C3d.
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PMC7215832
For instance, LINE-1 promoter methylation was observed in plasma of patients with advanced solid tumors, in attempts to use the promoter methylation of this gene as a biomarker for demethylating agent activity .
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PMC11634027
To examine whether Lft regulation is mediated through the D motif, we compared Lft overexpression and knockdown in control ds wing discs and ds wing discs.
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PMC10135767
Additionally, Kindlin-3 in calcium signaling mediated by LFA-1 serves as a link in the formation of a focal adhesion complex combined with LFA-1 and receptor for activated C kinase 1 (RACK1), which is associated with the activation of ORAI-1, the main membrane calcium channel .
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PMC11541241
The divergences between different studies indicate that the role of the TOR pathway in regulating plant defence response may hinge on several factors, for instance, the different signal pathways affected by TOR activation and inhibition, the signal output strength, and the specialized interaction between various plants and pathosystems.
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PMC11472569
Zhang et al. showed that tumor cell-derived exosomes containing circUHRF1 induce exhaustion in natural killer cells and drive resistance against anti-PD1 immunotherapy.
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PMC11295144
The box and whisker plot show the mean (square dot with no fill), median (horizontal line), and standard deviation (whiskers).
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PMC10507284
Scale bars, 100 μm.
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PMC11731614
We used the following mouse lines: WT C57B6; K14-Cre, homozygous; CD63-emGFP fl, homozygous; K14-Cre::CD63-emGFP fl heterogenous.
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PMC9817179
Future characterization of the functionally optimal interaction level will require quantification of the sizes of hubs or droplet-like puncta while measuring transcription activity.
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PMC9429973
In patients with both high SRC plus high basal OXPHOS, the overall survival shortage is significant (p=0.002), indicating that an high SRC associated to higher basal respiration in AML blast cells confers greater aggressiveness and resistance to the therapy (Figure 1d).
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PMC9429973
Aims: This study aims to investigate the transcriptomic characterizations of CAR-T products and bone marrow mononuclear cells, and identify predictive biomarkers for efficacy and toxicity.
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PMC11683240
PBS was aspirated as a control.
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PMC10993311
The significant model associations between the mean maternal DNAm level of each DMR and maternal biochemical parameters, fetal biometric measurements and neonate anthropometry after controlling for confounding factors are shown in Table 2.
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PMC10957991
The use of clinical samples has been approved by the Ethics Committee of Pirkanmaa Hospital District, reference no. R07082, sample cohort I. Cells were lysed with Lysis Buffer including 1% Triton X-100 in PBS together with Protease inhibitor Cocktail Set III (#539134, Calbiochem) and Phosphatase Inhibitor Cocktail Set II (#524625, Calbiochem) Millipore, Merck Life Science).
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PMC11591794
In this context, HeLa cell lines were seeded in 24-well plates at 5 × 10 cells/well, and the cells were incubated at 37 °C under 5% CO2 conditions.
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PMC11746948
The samples were then separated by SDS-PAGE and subjected to western blot analysis.
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PMC11127909
As described by Li , 2 mg of mitochondria was added to KCl media.
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PMC11377827
As USP43 was both a top hit on the screens and was itself regulated in a HIF-dependent manner, we focused our further studies on the actions of this DUB.
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PMC11731614
To estimate protein probabilities and false-discovery rates (FDR) accurately, we used a target/decoy database containing the reversed sequences of all the proteins appended to the target database (UniProt, 2015) (UniProt, 2015).
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PMC11773391
Analysis of apoptotic cells was performed by flow cytometry (Beckman, CA, USA).
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PMC3995603
Therefore, we conclude that AC should be explored as a potential therapeutic agent to treat atopic dermatitis.
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PMC11367146
The Differentially Expressed Genes (DEGs) of all three respective datasets were obtained for the normal and OA patients using iDEP 0.96 online tool.
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PMC9046263
As gliomas progress to higher grades, loss of the G-CIMP phenotype has been described, suggesting a potential link between HERV expression and glioma progression.
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PMC7171147
FASN mRNA expression was also reduced upon LY294002 treatment in A2780 cells (Fig. S5F).
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PMC8956657
A Detailed view of MERS ORF4b bound at the major site of IMPα2 (left) and IMPα3 (right).
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PMC11779993
The involvement of keratinocytes in wound healing encompasses various cellular and molecular events, including proliferation, migration, and epithelialization.
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PMC11789597
In our study, CAV1 knockdown further enhanced glutamine addiction by increasing ASCT2 and LAT1 and thus supporting redox homeostasis and cellular survival in vitro.
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PMC11754784
DNA bands were stained by Gel-Green and imaged using the Bio-Rad ChemiDoc XRS System with imaging software under UV light.
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PMC10926885
Additionally, we established a Cox proportional hazards regression mode using the coxph function of the R package ‘survival’ (version 3.2–7) and did statistical tests for prognostic significance using the Logrank test.
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PMC8633974
Other studies had achieved >90% reduction in HIV-1 reactivation and prevention of viral escape when CRISPR-Cas9 was lentivirally transduced in T cells at MOIs of 10-15 .
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PMC9919300
HepG2 cells 1 × 10 were seeded in 24-well culture plate and incubated for 24 h. On the next day, the medium was replaced with the lipid overload-conditioned medium, prepared as described above.
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PMC5574817
PCR efficiency (E) was determined using CT slope method with data points covering a log dilution range.
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PMC6948907
Each experiment was conducted in triplicate.
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PMC8711270
In complex retroviruses, viral genomic RNA functions as mRNA (Balvay et al., 2007).
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PMC10317042
Tumor volume (C) and weight (D) of SU-CCS1 and Hewga-CCS tumors during treatment are shown (n = 4). *,
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PMC11377827
HeLa cells were lysed in 1% Triton PBS or RIPA (25 mM Tris•HCl pH 7.6, 150 mM NaCl, 1%, NP-40, 1% sodium deoxycholate, 0.1% SDS), with 1× Roche complete EDTA-free protease inhibitor cocktail and 1:1000 Denarase for 30 min at 4 °C.
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PMC11240052
A Dual-Luciferase Reporter Assay was performed to evaluate the interaction between circ-0008285 and miR-211-5p.
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