OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC8751435	Chemical identifications were based on reference standards, chromatographic elution behaviors, chemical composition, mass fragment patterns, and mass spectral library (Natural Products HR MS/MS Spectral Library, Version 1.0, AB Sciex).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6799808	Ad-GFP-infected cells served as controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ad-GFP-infected", "cells", "served", "as", "controls", "." ] } ]
PMC11746948	The bound proteins were resolved by SDS-PAGE and immunoblotted with the indicated antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bound", "proteins", "were", "resolved", "by", "SDS-PAGE", "and", ...
PMC11764090	MaNAC1 is a target of MaICE1 and interacts with MaCBF1 to enhance cold stress response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MaNAC1", "is", "a", "target", "of", "MaICE1", "and", ...
PMC9599726	The human GIST882 cell line was kindly provided by Dr. Jonathan A. Fletcher, Harvard Medical School, Boston, MA, USA.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Patients who respond to cevostamab but develop recurrent or progressive disease after 13 cycles may be eligible for cevostamab re-treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "who", "respond",...
PMC11764090	Under greenhouse conditions close to natural light and photoperiod, chloroplasts maintains their activity in the upper plate .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Under", "greenhouse", "conditions", "close",...
PMC11635087	The baseline fluorescence intensity was labelled Fo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "baseline", "fluorescence", "intensity", "was", "labelled", "Fo", "." ] } ]
PMC11585587	Cleavage of PARP is considered an essential indicator of apoptosis and is often considered an indicator of Caspase 3 activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cleavage", "of", "PARP", ...
PMC11758416	The protocol below describes the steps for performing a cell cytotoxicity assay using L cells that express the Fc receptor - CD32, and the costimulatory receptor - CD80, cocultured with various phenotypes of CD8 T cells as effector cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9118379	Three OMS tools were used to search the 320 variant spectra against the huge SuperPep_V database. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "OMS", "tools", "were", "used", "to...
PMC10840195	It selectively inhibits PDGF-α/β, VEGFR-1/2/3, kit, FLT-3, CSF-1R and RET and has dual effects of killing tumour cells and inhibiting angiogenesis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11218145	Thus, we next moved to explore whether TB could somehow affect the mitochondrial functioning and dynamics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "we", "next", "moved", "to", ...
PMC9503541	It involves data acquisition using hyphenated analytical techniques (e.g., GC-MS, LC-MS, or NMR) and data mining or molecular networking using advanced bioinformatics tools (e.g., MS-DIAL, MetaboAnalyst, GNPS, and Cytoscape) to provide extensive metabolites data that help confirm the relationship between a specific compound and its bioactivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11704135	Its most pronounced activity was observed against C. albicans, S. haemolyticus, and S. epidermidis, with inhibition zone diameters of 19.33, 17.00, and 14.33 mm, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Data on comorbidity, sub grouped cumulative incidences, and additional risk estimates will be presented with the abstract.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "on", "comorbidity", ",", ...
PMC6102174	Bge.	[ { "tags": [ "O", "O" ], "tokens": [ "Bge", "." ] } ]
PMC11683240	The European Centre for Disease Prevention and Control reports a significant increase in pertussis cases in the EU/EEA, with over 25,000 cases in 2023 and more than 32,000 between January and March 2024.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	By IPSS-R cytogenetic scores, hMDS had scores of 3 than non-hMDS (20% vs. 9%, p<0.001), but non-hMDS had more cytogenetic scores of 4 (27% vs. 19%, p=0.018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Univariate and multivariate Cox regression analysis were used to estimate hazard ratios (HR) with a 95% confidence interval (CI) and adjusted to the Follicular Lymphoma International Prognostic Index (FLIPI) score.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9712534	Consistently, we observed a decrease in TOP2B, but not TOP2A, in the ICRF-treated WT/WT cells (Fig. 6b,c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10440586	Anti-tumor immunity is detrimental to cancer cells, but gliomas reshape the tumor immune microenvironment adapting to this stress and promoting cancer progression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anti-tu...
PMC11225860	MDA-MB-231, Hela, Mia PaCa-2, U-2 OS, Granta-519 cell lines also saw a significant drop in IC50 with the addition of 100µM Aurkin A (Table 1, Sup Fig. 2g–n).Table 1Summary of cell viability testing with combination alisertib and Aurkin A therapy in multiple cell lines.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8864075	After reconstructing with these three compounds [baicalein (65.8%), wogonin (21.2%), and oroxylin-A (13.0%)], the reconstructed TFAE (reTFAE) inhibited the EMT process of A549 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11686380	Scale bar, 200 μm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "200", "μm", ".", "(" ] } ]
PMC9065483	Moreover, gefitinib treatment could abrogate the viral sensitizing response of vanadium compounds in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "gefitinib", "treatment", "could", "abrogate", ...
PMC11706491	Plates were incubated in a Power Wave microplate scanning spectrophotometer (Bio-Tek) at 30°C with continuous shaking.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plates", "were", "incubated"...
PMC9454852	Consistent with the viability test, we observed a variation in the [Ca]i only in the REN cells, while no effect in the Met5A cells was observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "...
PMC6133382	Underlaying data can be found in S1 Data. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Underlaying", "data", "can", "be", "found", "in", "S1", "Data", ".", "(" ] } ]
PMC11742431	When the tumor volume grew to about 100 mm, KVN and K14N protein were administered, and the administration method was peritumoral administration, a total of five times with an interval of 3 days, and the nude mouse was weighed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9621239	Compared with genotype B clones (Figure 2A), the mutant hot spots in genotype (C&D) clones exhibited two clusters, including the dimerization region ranging from aa21 to aa50 and the fragment ranging from aa110 to aa140 within the transactivation region (Figure 2B and J), which was consistent with the entropy difference between genotype B and genotype (C&D) (Figure 2C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794588	These correlations, which were derived from various research papers, highlight the therapeutic value of these compounds in cancer treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "correlations",...
PMC11785489	As in our unimodal dimensionality reduction pipeline, we then removed batch effects from the per-cell mRNA-based canonical variate (CV) scores, constructed a UMAP and SNN graph based on the 10 batch-corrected CVs, and identified cell clusters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Follicular lymphoma (FL) (62.3%) and marginalzone lymphoma (MZL) (24.6%) were the main subtypes of iNHL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11052306	Additional experiments were carried out against the myeloid U937 tumor cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Additional", "experiments", "were", "carried", "out", "against", "the", "myeloid", ...
PMC11666785	This increases the chance of overlapping PSF in the image and may have consequences in recognizing molecules in the subsequent frames.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "increases", ...
PMC11721295	GSEA was performed using the fgsea R package.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GSEA", "was", "performed", "using", "the", "fgsea", "R", "package", "." ] } ]
PMC11222184	Our findings indicate that XL-888 and Debi0932 HSP90 inhibitors are important candidates for sensitizing neuroblastoma cells to radiotherapy and chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "findings", "indicate"...
PMC9895440	Fig. 4Snx9 KO improves anti-tumor efficacy and reduces terminal exhaustion in vivo.a Schematic experimental setup of OTI Snx9 KO generation and transfer to MC38-OVA-bearing mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ],...
PMC9429973	Image: Summary/Conclusion: In our meta-analysis, lenalidomide maintenance therapy could be an effective treatment option for patients with CLL in prolongation PFS and relatively acceptable in safety concerns.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748335	F Number of CGI promoters within an upregulated or hypermethylated group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", "Number", "of", "CGI", "promoters", "within", "an", "upregulated", "or", "hyperme...
PMC11590005	Values in bold indicate statistically significant difference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Values", "in", "bold", "indicate", "statistically", "significant", "difference", "." ] } ]
PMC11347429	The top 5 up- and down-regulated DEGs from this comparison and their known functions are listed in Table 3 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "top", "5", "up-", "a...
PMC10482220	Transfected Cos or HeLa cells were grown on coverslips and treated with 0.5 mM sodium arsenite 48 h after transfection.	[ { "tags": [ "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transfected", "C...
PMC11344246	Plates were incubated for another 72 h before another media change and second dosing, then left for a further 48 h before endpoint assays were performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7642379	Common differentially expressed (DE) genes in pairwise comparisons of all HEK293 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Common", "differentially", "expressed", "(", "DE", ")", "genes", ...
PMC11740573	Downregulation of pro-inflammatory cytokines by calcitriol in response to bacterial infection has been demonstrated in previous studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Downregulation", "of", "pro-inflammatory", "cytokines",...
PMC11401358	Fig. 1Schematic diagram of SF with an antioxidant function and its mechanism. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "1Schematic", "diagram", "of", "SF", "with", "an", "antioxidant", ...
PMC7757104	The results demonstrated that the OPNc cells also displayed high P-gp expression levels (Fig. 4B).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "demonstrated", "that", ...
PMC11711063	Studies demonstrated the role of compositional changes in matrisome proteins in breast cancer progression based on ECM proteins highly expressed in biopsies from invasive ductal carcinomas. ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615828	RIVET opens up new avenues for studying intracellular trafficking under various physiological and pathological conditions and offers potential strategies for treating trafficking‐related disorders.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RIVET",...
PMC11754094	However, we also observed that the frequency of large deletions was decreased in the RAD52 KO cell line, opposite to Cas9 nucleases (Figs. 3e and 4e), possibly implying a difference in DNA repair processes between Cas9- and BE-driven DSBs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787651	EMT of H1437 cells was induced by treating cells with Recombinant Human TGF-β1 (R&D System) at 10 ng/ml in their regular culture medium for 3 days.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10125312	A–F) Viability at 0 and 24 h after irradiation in control (CTL) and in cells irradiated with AuNR-PEG (+AuNR-PEG) and without (⌀AuNR-PEG). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	Procedures for detection methods and data analysis were described.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Procedures", "for", "detection", "methods", "and", "data", "analysis", "were", "described", "." ] } ]
PMC11545737	Through this mechanism, the meningococcus reaches the cytosol and is recognized by inflammasomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Through", "this", "mechanism", ",", "the", "meningococcus", "reaches",...
PMC11682224	Tumor tissues were aseptically separated, cut into 1 mm3 tissue blocks, digested in a mixture of 0.2% type IV collagenase and 0.25% trypsin at 37 °C, filtered through a 200-mesh sieve, and resuspended in PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	D. Kanevsky, J. Elgart, M. Zerga, M. Glancszpigel, P. Morisset Market Access, Abbvie, Buenos Aires; CENEXA, Center of Experimental and Applied Endocrinology (UNLP-CONICET, La Plata; Instituto de Oncología “Angel Roffo”.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The loss of MMR (BCR-ABL1 > 0.1%) indicates failure after TFR Aims: to follow patients having CML-CP who have achieve DMR 4.0 or more for at least two years, to allow TKl discontinuation with TFR as an aim.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9000591	Based on the TLC results, similar fractions including F1–F20, F21–F37, F38–F59, and F60–F139 were combined to retrieve a total of 4 samples encoded as SE1, SE2, SE3, and SE4, respectively (Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727638	In addition, both TK and KML-1 cells cultured in the Cell Dome exhibited higher resistance to DOX compared to those cultured in 2D flasks.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11351758	It is not uncommon to find a decrease in mitochondrial functions in neurodegenerative diseases, which is critical as far as mitochondrial biology is concerned; however, the molecular basis to confirm this is elusive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11723947	WGCNA identified 4 clusters for genes overexpressed in HP1γ KO Tconv compared with wild-type Tconv exposed to Treg with 51 (cluster 1), 340 (cluster 2), 58 (cluster 3) and 20 (cluster 4) genes, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11583010	Internalization of 15A7.5 and HA22 was detected at concentrations of 0.2 μg/mL and 0.008 μg/mL, respectively.	[ { "tags": [ "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Internalization", "of", "15A7.5", "an...
PMC11381192	UBE2G2 and ENO1 expression increased from SMM to NMM and RMM, while ALDH2 showed the opposite trend (Figure 8C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "UBE2G2", "an...
PMC8481254	Immunohistochemical (IHC) staining indicated that STZ treatment induced an increase in the levels of OGT, YAP, and O-GlcNAcylation; moreover, the levels of the key genes of HBP (SLC5A3 and Nudt9) increased significantly, and their expression significantly decreased in the tissue upon CA treatment (Fig. 3F).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11768281	The antagonistic relationship between Th1 and Th2 cells is further supported by a study conducted by Coomes et al., which observed that in Plasmodium and Helminth co-infection, a higher proportion of functional Th2 cells was present.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10729469	Antigen specificity was confirmed by MHC-Aβ-tetramer staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antigen", "specificity", "was", "confirmed", "by", "MHC-Aβ-tetramer", "staining", "." ] } ]
PMC9844987	TF binding site profiles and low/high CpG content (Figure 2—figure supplement 2A) were collected for each identified promoter and the resulting feature data were used to train a machine learning (random forest) classifier features associated with either high or low variability (low variable N=5054, highly variable N=5683).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11549612	The observed associations between BOLA1, BOLA2, and BOLA3 expression and immune subtypes provide valuable insights into the potential immunomodulatory roles of BOLA proteins in KIRC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11434983	Flow cytometry was performed using a FACS Calibur (Becton Dickinson, San Jose, CA, USA) flow cytometer using the ModFit v6 software (Verity Software House, Topsham, ME, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755467	It follows that, in analogy to hsa-miR-122, these miRNAs may serve as new therapeutic host-cell targets aggravating viral escape mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "follow...
PMC11746942	All mice were randomly assigned to different groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "mice", "were", "randomly", "assigned", "to", "different", "groups", "." ] } ]
PMC9429973	Recent studies have revealed that the intestinal microbiota could modulate the activity of immune system through creating an imbalance between cell proliferation and apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11266100	Electroporation presents numerous advantages in comparison to viral gene transfer methodology, including the ability to repeatedly administer to tissues without triggering substantial immune responses or toxicity, minimizing the occurrence of transgene expression at non-target sites, good stability, the capability to carry large amounts of material, high therapeutic efficacy, and low cost.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11545737	However, priming of macrophages with inflammatory stimuli is sufficient to induce pyroptosis in macrophages infected with Yersinia YopJ-deficient bacteria .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "priming", ...
PMC8735881	HEK293T cells were purchased from the American Type Culture Collection (ATCC; Rockville, MD).	[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HEK293", "T", "cells", "we...
PMC11680391	Here, the herd veterinarian could implement the motivational interview to improve agreement, which would be beneficial to improving the overall communication during consulting .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	These data also indicate that E from individuals with lower CR1 expression convert the iC3b to C3dg more slowly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "also", "indicate...
PMC10440586	Glioma cells are divided into four cell states: OPC-like, NPC-like, MES-like, and AC-like. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Glioma", "cells", "are", "divided", "i...
PMC9429973	Despite evidences of mutual interactions between AML cells and immune cells, their interplay is still poorly understood.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "evidences", "of", "mutual", ...
PMC11045125	We demonstrate that Myc blocks LMP1 expression both by inhibiting expression of cellular factors (STAT3 and Src) that activate LMP1 transcription and by increasing expression of proteins (DNMT3B and UHRF1) known to enhance DNA methylation of the LMP1 promoters in human BLs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794588	The findings indicated that the most active ingredients were in the ethanol extract of C. aurantiacum (Figs. 1, 2 and 3).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11129910	RAO-2 cells that express mutant H-RAS and RAB25 and other RAB25-negative clones with no RAS overexpression do not show any significant changes in any in vitro assays that confirm transformation, proving that the expression of the oncogene H-RAS61L alone is insufficient and RAB25 loss is required for cells to transform.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9164404	There were 25 metabolites significantly changed in the cells treated with Abplatin (Additional file 1: Table S5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "were", "25", ...
PMC9429973	Results: Totally, 529 consecutive lymphoma patients with 1,118 PET images were performed in this model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Totally", ",", "529", "cons...
PMC11760643	P2X7 is a trimeric ligand‐gated ion channel that is activated by extracellular adenosine 5′‐triphosphate (ATP) to induce the flux of Ca, Na, K, and organic ions across the cell membrane .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10380508	For instance, PAX2 and PAX8 are essential for initiating pro- and mesonephros development, and together they play a role in the expression of GATA binding protein 3 (GATA3) and initiating Hepatocyte nuclear factor 1 alpha, or beta (HNF1ba/b) expression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10723784	In addition, during the cell cycle, the cyclin‐dependent kinase inhibitor, p27 is activated and then binds to cyclin D, which subsequently inhibits the catalytic activity of Cdk4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10936243	Some don’t, some will do it away from that sleeping area” [D061]. “	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "do", "n’t", ",", "some", ...
PMC9429973	The combined genetic classification methods identified 3 and 4 patient subgroups, respectively, with significantly different 5-year progression-free survival rates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combined", ...
PMC10024132	Retroviral transduction of γ9δ2 T cells with blinatumomab- and GFP-encoding DNA was carried out in parallel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Retroviral", "transduction", "of", "γ9δ2", "T", "cells...
PMC11774747	Enhancing lymphodepletion prior to CAR-T cell infusion further reduces recipient T cell numbers, creating a more favorable environment for graft acceptance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enhancing", ...
PMC9352806	Meanwhile, BMS induced autophagy in OA-treated HepG2 cell via regulating p-AMPK and LC3B expressions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Meanwhile", ",", "BMS", "induced", "autophagy", "in", ...
PMC10454535	Half maximal inhibitory concentration (IC50) values were calculated for each compound using the “[inhibitor] vs. normalized response” setting on GraphPad Prism 9.3.1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11574029	Cells were seeded in 6-well plates, and a sterile plastic pipette tip was used to scratch the cell layer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "seeded", ...
PMC11673902	The combination of applying microfluidic technology to micropipettes not only improves the efficiency of the operation but also expands its potential for application in the field of cell mechanics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718109	E Line scan intensity profile showing overlapping fluorescence signals of VAMP2 and synapsin in an axon of a DA neuron.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", "Line", "scan", "i...
PMC10748106	Finally, after generating a QSAR model, we carried out a ligand-based drug design of new simple iridoids with potential cytotoxic activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally...
PMC9429973	The severity of SCD in KSA varies widely, likely due to existing haplotype variations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "severity", "of", "SCD", "in", "KSA", "varies", ...

PMC8751435

Chemical identifications were based on reference standards, chromatographic elution behaviors, chemical composition, mass fragment patterns, and mass spectral library (Natural Products HR MS/MS Spectral Library, Version 1.0, AB Sciex).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6799808

Ad-GFP-infected cells served as controls.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ad-GFP-infected", "cells", "served", "as", "controls", "." ] } ]

PMC11746948

The bound proteins were resolved by SDS-PAGE and immunoblotted with the indicated antibodies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bound", "proteins", "were", "resolved", "by", "SDS-PAGE", "and", ...

PMC11764090

MaNAC1 is a target of MaICE1 and interacts with MaCBF1 to enhance cold stress response.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MaNAC1", "is", "a", "target", "of", "MaICE1", "and", ...

PMC9599726

The human GIST882 cell line was kindly provided by Dr. Jonathan A. Fletcher, Harvard Medical School, Boston, MA, USA.

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PMC9429973

Patients who respond to cevostamab but develop recurrent or progressive disease after 13 cycles may be eligible for cevostamab re-treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "who", "respond",...

PMC11764090

Under greenhouse conditions close to natural light and photoperiod, chloroplasts maintains their activity in the upper plate .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Under", "greenhouse", "conditions", "close",...

PMC11635087

The baseline fluorescence intensity was labelled Fo.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "baseline", "fluorescence", "intensity", "was", "labelled", "Fo", "." ] } ]

PMC11585587

Cleavage of PARP is considered an essential indicator of apoptosis and is often considered an indicator of Caspase 3 activation.

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PMC11758416

The protocol below describes the steps for performing a cell cytotoxicity assay using L cells that express the Fc receptor - CD32, and the costimulatory receptor - CD80, cocultured with various phenotypes of CD8 T cells as effector cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9118379

Three OMS tools were used to search the 320 variant spectra against the huge SuperPep_V database. (

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PMC10840195

It selectively inhibits PDGF-α/β, VEGFR-1/2/3, kit, FLT-3, CSF-1R and RET and has dual effects of killing tumour cells and inhibiting angiogenesis .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11218145

Thus, we next moved to explore whether TB could somehow affect the mitochondrial functioning and dynamics.

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PMC9503541

It involves data acquisition using hyphenated analytical techniques (e.g., GC-MS, LC-MS, or NMR) and data mining or molecular networking using advanced bioinformatics tools (e.g., MS-DIAL, MetaboAnalyst, GNPS, and Cytoscape) to provide extensive metabolites data that help confirm the relationship between a specific compound and its bioactivity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11704135

Its most pronounced activity was observed against C. albicans, S. haemolyticus, and S. epidermidis, with inhibition zone diameters of 19.33, 17.00, and 14.33 mm, respectively.

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PMC9429973

Data on comorbidity, sub grouped cumulative incidences, and additional risk estimates will be presented with the abstract.

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PMC6102174

Bge.

[ { "tags": [ "O", "O" ], "tokens": [ "Bge", "." ] } ]

PMC11683240

The European Centre for Disease Prevention and Control reports a significant increase in pertussis cases in the EU/EEA, with over 25,000 cases in 2023 and more than 32,000 between January and March 2024.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

By IPSS-R cytogenetic scores, hMDS had scores of 3 than non-hMDS (20% vs. 9%, p<0.001), but non-hMDS had more cytogenetic scores of 4 (27% vs. 19%, p=0.018).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Univariate and multivariate Cox regression analysis were used to estimate hazard ratios (HR) with a 95% confidence interval (CI) and adjusted to the Follicular Lymphoma International Prognostic Index (FLIPI) score.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9712534

Consistently, we observed a decrease in TOP2B, but not TOP2A, in the ICRF-treated WT/WT cells (Fig. 6b,c).

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PMC10440586

Anti-tumor immunity is detrimental to cancer cells, but gliomas reshape the tumor immune microenvironment adapting to this stress and promoting cancer progression .

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PMC11225860

MDA-MB-231, Hela, Mia PaCa-2, U-2 OS, Granta-519 cell lines also saw a significant drop in IC50 with the addition of 100µM Aurkin A (Table 1, Sup Fig. 2g–n).Table 1Summary of cell viability testing with combination alisertib and Aurkin A therapy in multiple cell lines.

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PMC8864075

After reconstructing with these three compounds [baicalein (65.8%), wogonin (21.2%), and oroxylin-A (13.0%)], the reconstructed TFAE (reTFAE) inhibited the EMT process of A549 cells.

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PMC11686380

Scale bar, 200 μm. (

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PMC9065483

Moreover, gefitinib treatment could abrogate the viral sensitizing response of vanadium compounds in vivo.

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PMC11706491

Plates were incubated in a Power Wave microplate scanning spectrophotometer (Bio-Tek) at 30°C with continuous shaking.

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PMC9454852

Consistent with the viability test, we observed a variation in the [Ca]i only in the REN cells, while no effect in the Met5A cells was observed.

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PMC6133382

Underlaying data can be found in S1 Data. (

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PMC11742431

When the tumor volume grew to about 100 mm, KVN and K14N protein were administered, and the administration method was peritumoral administration, a total of five times with an interval of 3 days, and the nude mouse was weighed.

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PMC9621239

Compared with genotype B clones (Figure 2A), the mutant hot spots in genotype (C&D) clones exhibited two clusters, including the dimerization region ranging from aa21 to aa50 and the fragment ranging from aa110 to aa140 within the transactivation region (Figure 2B and J), which was consistent with the entropy difference between genotype B and genotype (C&D) (Figure 2C).

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PMC11794588

These correlations, which were derived from various research papers, highlight the therapeutic value of these compounds in cancer treatment.

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PMC11785489

As in our unimodal dimensionality reduction pipeline, we then removed batch effects from the per-cell mRNA-based canonical variate (CV) scores, constructed a UMAP and SNN graph based on the 10 batch-corrected CVs, and identified cell clusters.

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PMC9429973

Follicular lymphoma (FL) (62.3%) and marginalzone lymphoma (MZL) (24.6%) were the main subtypes of iNHL.

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PMC11052306

Additional experiments were carried out against the myeloid U937 tumor cells .

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PMC11666785

This increases the chance of overlapping PSF in the image and may have consequences in recognizing molecules in the subsequent frames.

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PMC11721295

GSEA was performed using the fgsea R package.

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PMC11222184

Our findings indicate that XL-888 and Debi0932 HSP90 inhibitors are important candidates for sensitizing neuroblastoma cells to radiotherapy and chemotherapy.

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PMC9895440

Fig. 4Snx9 KO improves anti-tumor efficacy and reduces terminal exhaustion in vivo.a Schematic experimental setup of OTI Snx9 KO generation and transfer to MC38-OVA-bearing mice.

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PMC9429973

Image: Summary/Conclusion: In our meta-analysis, lenalidomide maintenance therapy could be an effective treatment option for patients with CLL in prolongation PFS and relatively acceptable in safety concerns.

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PMC11748335

F Number of CGI promoters within an upregulated or hypermethylated group.

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PMC11590005

Values in bold indicate statistically significant difference.

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PMC11347429

The top 5 up- and down-regulated DEGs from this comparison and their known functions are listed in Table 3 .

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PMC10482220

Transfected Cos or HeLa cells were grown on coverslips and treated with 0.5 mM sodium arsenite 48 h after transfection.

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PMC11344246

Plates were incubated for another 72 h before another media change and second dosing, then left for a further 48 h before endpoint assays were performed.

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PMC7642379

Common differentially expressed (DE) genes in pairwise comparisons of all HEK293 cells.

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PMC11740573

Downregulation of pro-inflammatory cytokines by calcitriol in response to bacterial infection has been demonstrated in previous studies.

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PMC11401358

Fig. 1Schematic diagram of SF with an antioxidant function and its mechanism. (

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PMC7757104

The results demonstrated that the OPNc cells also displayed high P-gp expression levels (Fig. 4B).

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PMC11711063

Studies demonstrated the role of compositional changes in matrisome proteins in breast cancer progression based on ECM proteins highly expressed in biopsies from invasive ductal carcinomas. ,

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PMC11615828

RIVET opens up new avenues for studying intracellular trafficking under various physiological and pathological conditions and offers potential strategies for treating trafficking‐related disorders.

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PMC11754094

However, we also observed that the frequency of large deletions was decreased in the RAD52 KO cell line, opposite to Cas9 nucleases (Figs. 3e and 4e), possibly implying a difference in DNA repair processes between Cas9- and BE-driven DSBs.

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PMC11787651

EMT of H1437 cells was induced by treating cells with Recombinant Human TGF-β1 (R&D System) at 10 ng/ml in their regular culture medium for 3 days.

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PMC10125312

A–F) Viability at 0 and 24 h after irradiation in control (CTL) and in cells irradiated with AuNR-PEG (+AuNR-PEG) and without (⌀AuNR-PEG). (

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PMC11365427

Procedures for detection methods and data analysis were described.

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PMC11545737

Through this mechanism, the meningococcus reaches the cytosol and is recognized by inflammasomes.

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PMC11682224

Tumor tissues were aseptically separated, cut into 1 mm3 tissue blocks, digested in a mixture of 0.2% type IV collagenase and 0.25% trypsin at 37 °C, filtered through a 200-mesh sieve, and resuspended in PBS.

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PMC9429973

D. Kanevsky, J. Elgart, M. Zerga, M. Glancszpigel, P. Morisset Market Access, Abbvie, Buenos Aires; CENEXA, Center of Experimental and Applied Endocrinology (UNLP-CONICET, La Plata; Instituto de Oncología “Angel Roffo”.

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PMC9429973

The loss of MMR (BCR-ABL1 > 0.1%) indicates failure after TFR Aims: to follow patients having CML-CP who have achieve DMR 4.0 or more for at least two years, to allow TKl discontinuation with TFR as an aim.

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PMC9000591

Based on the TLC results, similar fractions including F1–F20, F21–F37, F38–F59, and F60–F139 were combined to retrieve a total of 4 samples encoded as SE1, SE2, SE3, and SE4, respectively (Table 2).

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PMC11727638

In addition, both TK and KML-1 cells cultured in the Cell Dome exhibited higher resistance to DOX compared to those cultured in 2D flasks.

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PMC11351758

It is not uncommon to find a decrease in mitochondrial functions in neurodegenerative diseases, which is critical as far as mitochondrial biology is concerned; however, the molecular basis to confirm this is elusive.

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PMC11723947

WGCNA identified 4 clusters for genes overexpressed in HP1γ KO Tconv compared with wild-type Tconv exposed to Treg with 51 (cluster 1), 340 (cluster 2), 58 (cluster 3) and 20 (cluster 4) genes, respectively.

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PMC11583010

Internalization of 15A7.5 and HA22 was detected at concentrations of 0.2 μg/mL and 0.008 μg/mL, respectively.

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PMC11381192

UBE2G2 and ENO1 expression increased from SMM to NMM and RMM, while ALDH2 showed the opposite trend (Figure 8C).

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PMC8481254

Immunohistochemical (IHC) staining indicated that STZ treatment induced an increase in the levels of OGT, YAP, and O-GlcNAcylation; moreover, the levels of the key genes of HBP (SLC5A3 and Nudt9) increased significantly, and their expression significantly decreased in the tissue upon CA treatment (Fig. 3F).Fig.

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PMC11768281

The antagonistic relationship between Th1 and Th2 cells is further supported by a study conducted by Coomes et al., which observed that in Plasmodium and Helminth co-infection, a higher proportion of functional Th2 cells was present.

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PMC10729469

Antigen specificity was confirmed by MHC-Aβ-tetramer staining.

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PMC9844987

TF binding site profiles and low/high CpG content (Figure 2—figure supplement 2A) were collected for each identified promoter and the resulting feature data were used to train a machine learning (random forest) classifier features associated with either high or low variability (low variable N=5054, highly variable N=5683).

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PMC11549612

The observed associations between BOLA1, BOLA2, and BOLA3 expression and immune subtypes provide valuable insights into the potential immunomodulatory roles of BOLA proteins in KIRC.

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PMC11434983

Flow cytometry was performed using a FACS Calibur (Becton Dickinson, San Jose, CA, USA) flow cytometer using the ModFit v6 software (Verity Software House, Topsham, ME, USA).

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PMC11755467

It follows that, in analogy to hsa-miR-122, these miRNAs may serve as new therapeutic host-cell targets aggravating viral escape mechanisms.

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PMC11746942

All mice were randomly assigned to different groups.

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PMC9429973

Recent studies have revealed that the intestinal microbiota could modulate the activity of immune system through creating an imbalance between cell proliferation and apoptosis.

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PMC11266100

Electroporation presents numerous advantages in comparison to viral gene transfer methodology, including the ability to repeatedly administer to tissues without triggering substantial immune responses or toxicity, minimizing the occurrence of transgene expression at non-target sites, good stability, the capability to carry large amounts of material, high therapeutic efficacy, and low cost.

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PMC11545737

However, priming of macrophages with inflammatory stimuli is sufficient to induce pyroptosis in macrophages infected with Yersinia YopJ-deficient bacteria .

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PMC8735881

HEK293T cells were purchased from the American Type Culture Collection (ATCC; Rockville, MD).

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PMC11680391

Here, the herd veterinarian could implement the motivational interview to improve agreement, which would be beneficial to improving the overall communication during consulting .

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PMC9429973

These data also indicate that E from individuals with lower CR1 expression convert the iC3b to C3dg more slowly.

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PMC10440586

Glioma cells are divided into four cell states: OPC-like, NPC-like, MES-like, and AC-like. (

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PMC9429973

Despite evidences of mutual interactions between AML cells and immune cells, their interplay is still poorly understood.

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PMC11045125

We demonstrate that Myc blocks LMP1 expression both by inhibiting expression of cellular factors (STAT3 and Src) that activate LMP1 transcription and by increasing expression of proteins (DNMT3B and UHRF1) known to enhance DNA methylation of the LMP1 promoters in human BLs.

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PMC11794588

The findings indicated that the most active ingredients were in the ethanol extract of C. aurantiacum (Figs. 1, 2 and 3).Fig.

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PMC11129910

RAO-2 cells that express mutant H-RAS and RAB25 and other RAB25-negative clones with no RAS overexpression do not show any significant changes in any in vitro assays that confirm transformation, proving that the expression of the oncogene H-RAS61L alone is insufficient and RAB25 loss is required for cells to transform.

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PMC9164404

There were 25 metabolites significantly changed in the cells treated with Abplatin (Additional file 1: Table S5).

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PMC9429973

Results: Totally, 529 consecutive lymphoma patients with 1,118 PET images were performed in this model.

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PMC11760643

P2X7 is a trimeric ligand‐gated ion channel that is activated by extracellular adenosine 5′‐triphosphate (ATP) to induce the flux of Ca, Na, K, and organic ions across the cell membrane .

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PMC10380508

For instance, PAX2 and PAX8 are essential for initiating pro- and mesonephros development, and together they play a role in the expression of GATA binding protein 3 (GATA3) and initiating Hepatocyte nuclear factor 1 alpha, or beta (HNF1ba/b) expression .

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PMC10723784

In addition, during the cell cycle, the cyclin‐dependent kinase inhibitor, p27 is activated and then binds to cyclin D, which subsequently inhibits the catalytic activity of Cdk4.

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PMC10936243

Some don’t, some will do it away from that sleeping area” [D061]. “

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PMC9429973

The combined genetic classification methods identified 3 and 4 patient subgroups, respectively, with significantly different 5-year progression-free survival rates.

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PMC10024132

Retroviral transduction of γ9δ2 T cells with blinatumomab- and GFP-encoding DNA was carried out in parallel.

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PMC11774747

Enhancing lymphodepletion prior to CAR-T cell infusion further reduces recipient T cell numbers, creating a more favorable environment for graft acceptance.

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PMC9352806

Meanwhile, BMS induced autophagy in OA-treated HepG2 cell via regulating p-AMPK and LC3B expressions.

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PMC10454535

Half maximal inhibitory concentration (IC50) values were calculated for each compound using the “[inhibitor] vs. normalized response” setting on GraphPad Prism 9.3.1.

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PMC11574029

Cells were seeded in 6-well plates, and a sterile plastic pipette tip was used to scratch the cell layer.

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PMC11673902

The combination of applying microfluidic technology to micropipettes not only improves the efficiency of the operation but also expands its potential for application in the field of cell mechanics.

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PMC11718109

E Line scan intensity profile showing overlapping fluorescence signals of VAMP2 and synapsin in an axon of a DA neuron.

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PMC10748106

Finally, after generating a QSAR model, we carried out a ligand-based drug design of new simple iridoids with potential cytotoxic activity.

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PMC9429973

The severity of SCD in KSA varies widely, likely due to existing haplotype variations.

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