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OTAR3088
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BioData-CellLine_annotated

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PMC8193046
Besides the above mentioned 56 class 7 compounds , , , , , , , , , , , , , , , , , , , , , , , , , , further 20 compounds are known which exert their inhibitor effect against ABCB1, ABCC1, and/or ABCG2 up to 15.0 µM , , , , , , , , , , , .
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PMC9429973
Decompressive laminectomy was carried out one time.
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PMC7215832
CEM cells have been used as a model to determine whether promoter hypomethylation increased the uptake of MTX and PMX .
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PMC11746942
Studies have shown that serum levels of sphingosine-1-phosphate (S1P) are significantly elevated in patients with psoriasis .
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PMC11697065
Protein quantification requirements were set at 1 unique and razor peptide.
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PMC9429973
PCR testing for the detection of SARS-CoV-2 RNA in nasopharyngeal samples from the staff of the center was performed using the PCR-RV-2019-nCov kit (Syntol, Russia).
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PMC9429973
Image: Summary/Conclusion: In our retrospective single institution experience, AA patients with SMM had a lower risk of progression to MM compared to whites.
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PMC10899471
These findings suggest that suppressing miR-939-3p or inducing BATF2 expression may represent a new therapeutic strategy for sarcoma treatment, which may provide novel insights for the development of potent therapeutic approaches for sarcoma patients.
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PMC8409415
Of those, 19 (38.0%) and 15 (30.0%) showed high and low CD70 expression.
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PMC3931643
All compounds were dissolved in DMSO at 10 mM and stored frozen in aliquots.
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PMC10093184
Surprisingly, COS3600 and COS3600B cells, both originating from the same tumor, revealed a marked DT difference that might be related to the intra-tumoral heterogeneity.
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PMC3931643
Indeed, MLN0128 and rapamycin did not decrease MCL-1 protein amounts in VAL cells, in contrast to the 4EBP1 expressing cell lines OCI-LY1 and OCI-LY7 ( Fig. 4b ).
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PMC4485786
This strategy seems highly promising for implementation of the TH1-induced senescence pathway in the treatment of aggressive solid malignancies.
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PMC11672617
These include a chiral and rigid skeleton, as well as the presence of free carboxyl and hydroxyl groups .
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PMC9509578
The nanoformulation was evaluated in CHOK1 cells and gene silencing via siMDR1 was performed in CD133+ HT-29 colon cells which exhibited efficient MDR1 gene knockdown and enhanced intracellular retention of paclitaxel and associated antitumor potency in colon cancer CSCs .
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PMC11687167
A paper published in 2020 by Hiurma et al. reported that most lipid-related molecules were decreased in patients with SLE compared with controls and this downregulation included PCSK9.
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PMC11365427
n = 5. (
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PMC9841531
Concentration-effect curves of the antineoplastic agent 33 without (solid circles) and with 1.0 μM (solid up triangles), 2.0 μM (solid down triangles), 3.5 μM (solid diamonds), and 5.0 μM (solid squares) of either compound 24 (A) or 30 (B), as determined in an MTT-based cell viability assay using ABCB1-expressing A2780/ADR cells compared to the concentration-effect curve of 33 against the sensitive A2780 cell line (open circles).
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PMC11267830
Agarose gels of 0.7% and 1.2% (SIGMA, A9045-10G) and 2 × RPMI 1640 medium (YuChun, YC-1010) supplemented with 20% FBS, penicillin, and streptomycin were prepared.
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PMC9429973
One of the main challenges is that current targets for myeloid malignancies are either widely expressed on healthy hemopoietic stem cells such as CD33 or specific for a group of tumor cells presented as Lewis Y antigen, which could cause lasting bone marrow depression induced by “on target off tumor” side-effect or target negative relapse.
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PMC11066331
The heatmaps clearly revealed two clusters in data, dependent solely on peak intensities.
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PMC11544771
To this end, A549 and A427 cells were pretreated with or without PRE (20 nM) for 2 h, and then treated with CPX (0–20 μM) for 24 h. Our Western blot analysis showed that treatment with CPX alone did not obviously alter the expression of anti-apoptotic proteins (Bcl2, Bcl-xL) and pro-apoptotic proteins (BAD, BAK), but dose-dependently decreased the level of anti-apoptotic protein survivin in A549 and A427 cells, and the inhibitory effect of CPX on the survivin expression was strengthened by PRE pretreatment (Figure 6C,D and Figure S4C,D).
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PMC8316344
In our present study, the effects and mechanisms by which TRIB2 modulates the sensitivity of cells to ferroptosis via iron metabolism were investigated.
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PMC9592219
Chromosomal instability (CIN) is a major feature of cancer cells and is associated with DNA unwinding and mutations and epigenetic modifications of repair genes (topoisomerase family genes) .
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PMC11700340
Consequently, overexpression of HSP contributes to tumor advancement and the development of resistance to treatment; aside from inhibiting programmed cell death, the abnormal regulation of Heat Shock Proteins (HSPs) plays crucial roles in the rapid growth, invasiveness, and spread of tumors .
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PMC11541409
In a phase III clinical trial on patients with confirmed unresectable or metastatic GIST and had not received previous systemic therapy for GIST or had a recurrence of GIST 6 months or more after stopping imatinib treatment (647 patients enrolled), 2-year PFS of nilotinib group (324 patients, 400 mg/day) (51.6%) showed no superior efficacy than imatinib group (320 patients, 400 mg/day) (59.2%) as first-line therapy for advanced GISTs .
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PMC11585587
However, most research on the anti-tumor effects of RA has concentrated on solid tumors, with little exploration into non-solid tumors like MM.
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PMC11684821
The principal function of this highly conserved molecule involves presenting microbial metabolites to the abundant mucosal-associated invariant T (MAIT) cell subset.
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PMC11087055
Streamlines, visualizing averaged cell flows during each time period. (
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PMC11496491
Patients diagnosed with diabetic foot ulcer and undergoing TCTD surgery; No trauma or tumor around the ulcer; Patients having a detailed medical history; Long-term follow-up results; Wound edge specimens were obtained when the patient underwent TCTD surgery combined with debridement, and wound edge specimens were also obtained at the last debridement suture.
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PMC11087055
Blue, clockwise; red, counter-clockwise rotation.
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PMC6133382
The glycans that decorate the surface of native, virion-associated Envs are typically enriched for high-mannose variants, normally found on early intermediate proteins within the endoplasmic reticulum (ER) and early Golgi .
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PMC11468365
Additionally, cell line features are derived from gene expression data, with a multi-layer perceptron used to process these features.
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PMC9429973
Our data do not support the combination of platinum derivates and EZH2i in PTCL.
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PMC10522430
Moreover, a pronounced peak at 1004.48 cm, denoting the C-O bending mode, highlighted the presence of compounds such as alcohols, carboxylic acids, esters, and ethers.
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PMC10878518
Scale bars: 50 μm. (
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PMC9429973
Moreover, 80% of the CRi pts also achieved partial hematology recovery (CRh).
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PMC11791203
Each apoptosome recruits seven caspase-9 dimers, promoting their activation and leading to proteolytic self-processing.
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PMC11188874
Several methods have identified drugs and small molecules that modulate proteasome activity and proteasomes have been pharmacologically targeted to treat human diseases (19–22).
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PMC11180402
Western blot analysis of SOX2 expression in 5637 (SOX2) and 5637 (Vector) cells; GAPDH as control. (
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PMC9388315
The specificity of PCR products was verified by gel electrophoresis in 1% agarose.
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PMC11093197
Immunoblotting of indicated proteins in MCF10A cells. *
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PMC11529598
Our data indicated that miR-3154 acts as a pro-oncogenic miRNA in glioblastoma.
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PMC11638255
Collectively, these data demonstrate the impact of copper chelation in the neuroblastoma tumor microenvironment, including tumoral downregulation of Mycn and its targets and increased neutrophil infiltration.
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PMC11587606
Fig. 2RHBDF1 facilitates PKCζ activation and accumulation in cell nucleus. (
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PMC11482552
From Table 1 and Figure 4, we observed that the number of cells obtained using the QC-CCR5 assay correlates to the actual number of cells counted using the Thoma chamber and FACS.
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PMC9429973
Results: Using AmpliSeq (Illumina) fusion panel adapted for 20 KMT2A fusion transcripts and DNA fragments mimicking these fusion transcripts, 19 amplicons could be obtained with mPZR.
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PMC8873393
D Distribution of number of introns per gene.
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PMC11487720
The complex exhibited the presence of pY33-WWOX and pS46-p53 when interacting with TRAF2.
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PMC11144200
n = 5, **P < 0.01, ***P < 0.001.
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PMC11661040
Compared with the control group, the proliferation capacity of osteosarcoma cells was enhanced after the use of wnt signaling pathway activator.
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PMC9429973
Day-30 mortality (2.9% vs 19.4%; p=0.017; HR: 7.028; 95% CI: 1.418-34.836) and day-100 mortality (9% vs 33%; p=0.004; HR: 4.469; 95% CI: 1.619-12.336) were significantly lower in the low-mEASIX group.
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PMC11566417
Colors depict relative quantification (RQ) values where blue corresponds to low and yellow to high values.
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PMC11629461
Note that brief incubation with SALPC has been used before for plasma membrane‐localized type II photodynamic action, to activate the cholecystokinin 1 receptor. , , ,
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PMC11392912
The images were obtained by Chemidoc (Bio-Rad, U.S.A.) and analyzed by image lab software (Bio-Rad, U.S.A.) .
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PMC11711871
The mouse sEH (m sEH; 64 kDa) was used as a positive control; unspecific bands.
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PMC11322866
Meanwhile, in the RRM2 OE or GSK126-treated cells, blue arrows indicate swollen mitochondria lacking cristae.
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PMC11499381
We used these CGRP-responsive receptors as a model system because heterodimerization of CLR or CTR with RAMP1 is well supported [11–14].
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PMC10759659
In addition, the immune infiltration status of the tumour purity, immune components, and overall stromal status in the CHCC-HBV cohort was computed using ESTIMATE.
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PMC9596868
Software gave CI values of the combinations (Supplementary Table 1A).
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PMC11754436
D + mm represents the DHRS4-AS1 + miR-362-5p mimic group, indicating that both DHRS4-AS1 and miR-362-5p are overexpressed.
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PMC11407042
Increase the incubation time of co-culture from 4 h to 6–8 h. Do not incubate for more than 12 h, because cell proliferation may occur.
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PMC11604768
However, as observed in the MPRA experiment, inhibition of Gαq did not block the response of the THRB-1 promoter to NTSR1 agonism, suggesting alternative signaling cascades activated by NTSR1 can induce THRB-1 promoters.
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PMC11755519
This fusion is mediated by the SNAREs and Rab families of proteins, as well as adhesion molecules, lipid raft-like domains, and integrins present on their surface.
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PMC11597291
At predetermined time intervals (30 min, 1, 2, 4, 6, 12, 24, 48 h), the release medium was completely removed and replaced with fresh PBS at 37 °C.
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PMC11269933
After 36 hours, the PK enzyme activity assay was performed following the aforementioned procedure.
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PMC9429973
Understanding the immunological basis of T-cell response in allergy may help in developing strategies to mediate this toxicity, to further improve outcomes in children with ALL.
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PMC11564405
The synergistic integration of cutting-edge technologies further enhances the depth of analysis in this study, ensuring a multifaceted exploration of the visual landscape.
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PMC11533140
These four compounds were further evaluated for their antiproliferative activity against cancer cells.
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PMC10933092
Meanwhile, 497 lncRNAs were identified with mA down-methylation and 277 genes were up-methylation and the percent of genes downregulated by mA up-methylation was 21.6% (Figure 4B and Supplementary Table S3).
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PMC11766174
Treatment of P/I-reactivated cells with TACK reduced the proportion of capsid expressing cells to ~0.1% (p < 0.05).
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PMC10203589
Interestingly, the clonogenicity, proliferation, spheroid growth and migration ability of MPM cells were significantly decreased by FGFR1 inhibition.
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PMC11767725
These bacteria release antigens that further amplify inflammation by activating Toll-like receptor 2 (TLR2) on keratinocytes and immune cells.
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PMC10743717
and related experimental data were displayed in Table 2 and Figure 3 of Ref. .
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PMC9581083
M. alba aqueous extract has exhibited activity against various stages of the dengue virus replication cycle (Kim and Chung, 2018).
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PMC11088135
Fig. 3LncRNA NUTM2A-AS1 negatively regulates miR-376a-3p in U251 cell line.
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PMC10968586
Among gastric cancers, gastric adenocarcinoma is the most common subtype .
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PMC11335267
Accordingly, the transient increase in food intake observed in our own and other studies after administration of D-Trp8-γMSH could be interpreted as the consequence of transiently decreased satiety signals due to autoreceptor-induced inhibition of Pomc neuron activity.
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PMC9786247
Mastitis in dairy herds of cattle is associated with shedding of C. burnetii in milk.
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PMC10125312
Statistical comparisons were made using Tukey/Wilcox post hoc tests. *
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PMC11756514
The signal from the GFP-labelled bacteria was detected using the NovoCyte 3000 flow cytometer, as described above.
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PMC11185260
Antibodies recognizing Lamin B1 (#sc-377000, 1:1000 dilution, Santa Cruz Biotechnology, Dallas, TX, USA) were used as internal controls for protein loading.
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PMC11674834
This suggests the importance of NAT1*14B in cancer risk following alkylaniline exposures, especially for those that are preferential substrates for NAT1, such as 3,4-DMA.
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PMC11337594
Activated CASP3 in this pathway promotes apoptosis on the one hand, and on the other hand, it continues to cleave GSDME to trigger pyroptosis, and ultimately stimulates A375 cell death in the form of apoptosis and pyroptosis coexistence.
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PMC11755519
EV, extracellular vesicles.
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PMC9429973
Pooled risk ratios (RR) with 95% confidence intervals (CI) were calculated using the Mantel-Haenszel method of the fixed-effect model.
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PMC7757104
Nakamura et al (19) have demonstrated that prostate cancer cells overexpressing OPNb and OPNc are more resistant to docetaxel compared with cells transfected with an empty vector and exhibit a typical mesenchymal phenotype.
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PMC9429973
Among the 114 patients, 61 underwent watchful waiting and 53 received further treatment including localized radiotherapy, chemotherapy (including immunochemotherapy), or combined radiotherapy and chemotherapy.
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PMC11679326
MGAT5 silencing reduced terminal SLe expression in N-glycans, thus changing adhesion and migration properties in high-grade glioma cells (Figure 1f) .
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PMC11680578
Our findings demonstrate that the synergistic treatment leads to a decrease in mitochondrial membrane potential, triggers apoptosis, halts cell cycle progression and decreases cancer stemness in the SKOV-3 cell line and impedes angiogenesis in the CAM model.
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PMC11738017
Raw values for the triplicate experiments of cell viability measurement and calculated P values are indicated in supplemental Tables 5-7. (
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PMC7841189
LTBP2 was shown to play a vital role in tumorigenesis.
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PMC11361748
The antibodies used are listed in S1 Table.
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PMC9504875
Sendai virus (SeV) strain Cantell was kindly provided by Dr. T. Sakaguchi (Hiroshima University, Hiroshima, Japan).
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PMC11622247
For example, at 1 nM target the standard deviation amounts to 17% of the signal provided by C7-QB-OMe but only to 3% for C7-2AF568-QB-OMe.
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PMC11594074
Virtual screening was used to assess the binding affinity of more than 11,000 compounds to DNMT1.
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PMC10936243
For that, the first thing is the cages are costly, and secondly, we also don’t have much space if we want to order many, so we try to as much as possible to provide a comfortable space, if we can’t, then there is nothing we can do.
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PMC11583010
ETx-22 membrane staining spread into the tumor at 3 hours and peaked at 6 to 24 hours (Fig. 5A).
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PMC11371627
In this case report we present the clinical, genetic and immunological characterization of a patient with a yet unpublished, but pathogenic deletion in XK.
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PMC11753435
For the final model, ei = 1280, eo = 320, and h = 2.
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