OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9577200	However, the overuse of antibiotics as antibacterial and anticancer treatments can cause side effects and lead to drug-resistant bacteria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", ...
PMC11615101	The bar graph represents p-65 level after knockdown of α-Taxilin and pure protein induction of TNF-α and α-Taxilin. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bar", "graph", "represents...
PMC11742290	C57/BL6 mice LGR5 KD significantly reduced proliferation and colony formationColorectalColon cancer cell line: CT-26 LGR5 was associated with the maintenance of colon cancer.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10969097	Treatments involving breast cancer cells subjected to simultaneous administration of Suillus collinitus methanolic extract and etoposide resulted in greater cell growth inhibition than treatment with each component isolated .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11659921	CCK‐8 solution was applied at the indicated time points.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CCK‐8", "solution", "was", "applied", "at", "the", "indicated", "time", "points", "." ] } ]
PMC9031474	We must then ask: why have none of the aforementioned drimanes or coloratanes made it into the clinic yet?	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "must", "then", "...
PMC11700523	Previous studies have reported that indoxyl sulfate (IS), a major uremic toxin, leads to CKD by inducing tubular and podocyte injury, vascular inflammation, and calcification [3-5].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11745600	Male (n = 4; A) and female (n = 4; B) Ins1 NOG mice at 8–9 wk of age were used for hSC-islet cell transplantation experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10965680	Neighbor-joining (NJ) tree of the 159 individuals based on the matrix of Hamming genetic distance. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Neighbor-joining", "(", "NJ", ")", "tr...
PMC11787355	Thus, our data suggest a differential but synergistic role for CD4 and CD8 T cells following antigen-specific activation via PTPRZ1 TCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", ...
PMC11361748	Analysis of these 209 genes using the Panther statistical overrepresentation test indicated an enrichment for genes involved in neutrophil function and regulation, e.g., Dectin-2 family , GPVI proteins , and cytokine and chemokine production (S7 Table).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742864	The main challenge is maintaining the balance of good and bad inflammatory effects, so a better understanding on the interactions between ω-3 LCPUFAs and inflammation in lung cancer is critical.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727000	BRCA2 is tightly correlated with a proliferation gene signature in neuroblastoma across the SEQC, Primary NRC, and TARGET datasets (Pearson R = 0.894, 0.870, and 0.876, respectively; Figure 4E), perhaps explaining the association with these measures of aggressive disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11412721	p<0.001, *p<0.05, °p=0.07 by Student’s t-test. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p<0.001", ",", "*", "p<0.05", ",", "°", "p=0.07", "by", "Student", "’s", ...
PMC11568601	Scale bar = 100 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "100", "μm", "." ] } ]
PMC9368503	Taken together, our data suggest that targeting the PI3K-mTOR pathway may have utility particularly in the context of chemotherapy-resistant synovial sarcoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taken", "tog...
PMC11730000	In the DOX-treated group, the expression of mTOR protein was notably suppressed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "DOX-treated", "group", ",", "the", "expression", "of", "...
PMC11763764	Treatments with FGFR4 inhibitors, FGF401 and fisogatinib, both decreased the viability of OVCAR8 and KRCH31 cells with lower EC50 values compared to carboplatin (Figure 6A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11747949	143B cell phenotype in mono‐culture and coculture with immune cells. (	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "143B", "cell", "phenotype", "in", "mono‐culture", "and", "coculture", "with", "imm...
PMC11534035	SERPINE1/PAI1 knockdown impacts cell proliferation in A431 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "SERPINE1/PAI1", "knockdown", "impacts", "cell", "proliferation", "in", "A431", "cells", "." ] } ]
PMC11670407	Notably, OTULIN overexpression had no significant effect on the proliferative, invasive, or migratory capacities of osteosarcoma cells with or without cisplatin administration (Fig. 2c, d, g, h, k, l, n).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	However, HSCT indications might vary across countries, and who should not be transplanted is still a matter of debate since HSCT mortality scores lack validation in SCD settings.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8143558	Of these species, only 15 species from 10 families have actually been reported as being used for soaps or shampoos in various communities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Summary/Conclusion: Overall, our data provide evidence for B-cell dysregulations mediated by reduced Pax5 levels in the germline of mice and men.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary...
PMC5034105	Briefly, 200 μL of supernatant were used for extraction and the TNA was eluted in 60 μL of AVE buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "2...
PMC9927933	To this end, we arrested cells at the G1/S boundary by double thymidine blockage and then collected cells at various time points after releasing, followed by immunoblotting (IB) for the levels of DEPTOR, along with UBE2C/2S, CDH1, CDC20, and a few known substrates of APC/C E3, including PLK1, cyclin B1, and securin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727000	Spectra were analyzed using MaxQuant software version 1.5.5.1 against the Homo sapiens Uniprot protein sequence database (version July 2016) and GPM cRAP sequences (commonly known protein contaminants).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9954564	Ultimately, a pool of DNA libraries of up to 96 samples was diluted to 16 pM and inserted as input for sequencing using the MiSeq Reagent Kit V3 (600 cycles) in the MiSeq Personal Sequencer (Illumina Inc., San Diego, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11402217	Given the significant involvement of DKK1 and the Wnt/β-catenin signaling pathway in bone-destructive diseases, it is reasonable to hypothesize that DKK1 may act as an oncogene in OS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7171147	Peptide fractions were separated using a 50 cm EASY-Spray analytical column on an EASY nLC 1000 ultraperformance LC system and analyzed by an LTQ Orbitrap Elite mass spectrometer (Thermo Scientific).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Thymoglobulin (rabbit ATG, Genzyme, dose range 4.5 -11.25 mg/kg) was the T cell depletion used in all conditioning regimens except for Fanconi anaemia (FA), where alemtuzumab 0.3 and 0.9 mg/kg was used for Sib and unrelated transplantation, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8922418	Therefore, the HIV-1 reservoir can be converted to noninfectious proviral DNA by key amino acid mutations that are important for viral infectivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefo...
PMC11216402	The 11,312 tissue-specific genes (described above) were used to calculate the correlation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "11,312", "tissue-specific", "genes", "(", "described", "above",...
PMC11747467	Of note, we selected ART as the combination drug with RC48 rather than BP-1-102 and Stattic.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "note", ",", "we", "se...
PMC8270637	Summary of the mechanism by which TGF-β1 up-regulates the expression of PD-1 and CTLA-4 in T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary", "of", "the", "mechanism", "by", "...
PMC11271800	It is important to note that imatinib treatment can be a “double-edged sword” for patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "important", "to", "note", "that...
PMC10196713	Cells were treated with 1 µM penicillamine 48 h, thereafter cells were incubated in WST working solution and Enzyme working solution at 37°C for 20 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11424574	ERK1/2 is involved in MTA2-mediated regulation of human osteosarcoma cell migration and invasion. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ERK1/2", "is", "involved", "in", "MTA2-mediated", "regulation", "of", ...
PMC11705067	Further studies demonstrated that FDX1 expression was positively correlated with infiltration levels of eosinophils and mast cells (r = 0.168, P < 0.001), neutrophils (r = 0.172, P < 0.001), but negatively correlated with cytotoxic cells (r = -0.239, P < 0.001) and TReg (r = -0.314, P < 0.001), while there was no significant correlation with B cells (r = -0.073, P < 0.090).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11590005	Values in bold indicate statistically significant difference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Values", "in", "bold", "indicate", "statistically", "significant", "difference", "." ] } ]
PMC10291556	COX isoform COX-2 is frequently expressed in many types of cancer and induces CSC-like activity, promoting apoptotic resistance, proliferation, angiogenesis, inflammation, invasion, and metastasis of cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3931643	There was no detectable 4EBP1 mRNA in VAL cells in contrast to the OCI-LY1 and OCI-LY7 cell lines (Fig. S3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": ...
PMC11699465	TMEM199 regulate PD-L1 mRNA level (A) Relative TMEM199 expression level in TMEM199 knock out cells with different oligos (∗, p < 0.05; ∗∗, p < 0.01; ∗∗∗, p < 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2777936	This observation was made consistently with the two independent siRNA sequences targeting FZD7 and is viewed to be a consequence of FZD7 repression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...
PMC11049548	For example, concerning migration, A2780 behaved similarly to PEO1, PEO4, and FUOV1, which are HGSOC cell lines; COV318 cells, instead, are genomically classified as a high-grade serous cell line but behave similarly to non-serous cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", ...
PMC11708541	Antitrypanosomal therapy of revived diseases in immunosuppressed patients results in declined intensity of parasitemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antitrypanosomal", "therapy", "of", "revived", "diseases", "in", "immu...
PMC11699042	cDNA was fragmented, and TruSeq-Adapters ligated with the NEBNext® Ultra™ II FS DNA Library Prep Kit for Illumina® (NEB), and 3’-end-fragments were finally amplified using primers with Illumina P5 and P7 overhangs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755519	Subsequent results confirmed that VEGFR3 expression was significantly upregulated in HLECs with tumor cell exosomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequent", "results", "confirmed", "that", "VEGFR3", "expressio...
PMC11314247	no. 1620177; Bio-Rad Laboratories, Inc.).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "no.", "1620177", ";", "Bio-Rad", "Laboratories", ",", "Inc.", ")", "." ] } ]
PMC11337594	The results showed that the inhibitory effect of TER on Cyclin A2 expression increased with the increase of TER concentration and was alleviated after p53 knockout (Fig. 4D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11088135	Fig. 9LncRNA NUTM2A-AS1 positively regulates of YAP1 expression in U251 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Fig.", "9LncRNA", "NUTM2A-AS1", "positively", "regulates", "of", "YAP1", "expression", ...
PMC3765139	CD133 expression (brown spots, black arrows) in different tissue samples: A: normal skin section showing a few brown spots.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11607321	Taken together, our findings suggest a broad association of 1-methylnicotinamide and EMT across hundreds of cancer cell lines with a potential role in drug resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10551595	Cys124 was previously introduced as a critical amino acid that plays a pivotal role in the restoration of TP53 function. ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cys124", "was", "...
PMC9841531	Yellow crystals; yield: 65%; melting point: 192–194 °C; FTIR (cm): 3292.94 (NH), 2214.52 (CN), 1721.24 (C=O), 1673.19 (C=O), 1593.89 (C=C); H NMR (400 MHz, DMSO-d6) δ 10.56 (s, 1H), 8.67 (s, 1H), 8.58 (s, 1H), 8.08–7.84 (m, 1H), 7.61 (dd, J = 8.1, 5.3 Hz, 3H), 7.33 (m, 4H), 7.19–6.87 (m, 1H), 5.35 (s, 2H), 3.84 (s, 3H); MS (m/z) calculated for C21H17N3O3: 359.127, found: 377.25 [M + H2O] and 382.150 [M + Na]; purity (HPLC): 98%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11704834	It is noteworthy that TLE1 has been shown to transcriptionally upregulate Bcl-2 expression (21).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "noteworthy", "that", "TLE1", "has", ...
PMC11240052	Several studies have shown one of the main roles of circRNAs is the sponging of miRNAs and via this function participate in circRNA, miRNA, and target gene networks for regulating cancer pathogenesis (34–37).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	In fact, this phenomenon has been observed in both normal and malignant cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "fact", ",", "this", "phenomenon", "has", "been", "observed...
PMC11750712	Whole blood was extracted from each cone and diluted to 50 ml with sterile PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whole", "blood", "was", "extracted", "from", "each", "cone"...
PMC11532793	The distributional assumptions made by edgeR have been described by Chen et al. (14).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "distributional", "assumptions", "made", "by", "...
PMC3730428	REN cell line was donated by Prof. Steven M. Albelda, University of Pennslyvania Medical center, Philadelphia, USA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "REN", "cell", "line", ...
PMC11705862	The quantification is shown in (E). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "quantification", "is", "shown", "in", "(", "E", ")", ".", "(" ] } ]
PMC9672323	To conclude, our study adds to the growing literature on the anti-cancer properties of NSAIDs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "conclude", ",", "our", "study", "adds", "t...
PMC9786247	Deploying more markers than were used in our study may also help to better link genotypes to phenotypes, even though more isolates would have to be included to represent each subcluster in sufficient numbers to confirm correlations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11380329	So far, there is lack of methods recommended for screening and early diagnosis of this disease .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "So", "far", ",", "there", "is", "lack", ...
PMC11216402	To calculate the CN burden in GC cell lines, we converted the CNVkit output to a GISTIC-like integer score (ranging from −2 to +2; described above).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11674891	The role of GRPR in cell lines with other driver mutations, including EGFR, needs to be discovered in future studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "role"...
PMC11536589	The pseudo-time trajectories analysis of all KPC cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "pseudo-time", "trajectories", "analysis", "of", "all", "KPC", "cells", ".", "(" ] } ]
PMC9583612	SeekOps provided a summary report of measured emissions and wind-roses with detailed notes at each site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SeekOps", "provided", "a", "summary", "report", "of", ...
PMC11310713	Coupling with the previous results of recovery of ovarian sex hormone level in GTB-injected rats similar to ovary-intact rats, this indicates that the injected GTBs induced a balanced HPO axis through the normal action of the negative feedback system, leading to the restoration of endocrine function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9261184	The natural gas supply chain is a key emission source, where methane emissions from liquefied natural gas (LNG) shipping have until now not been directly measured.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11661040	Additionally, there was a notable decrease in Cyclin D expression levels observed in the CGREF1 knockdown group when compared to the control group (Fig. 7D, E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10849234	Error bars represent the standard deviation and statistical comparison was done using a two-tailed student’s t-test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "represent", "the", "standard", ...
PMC9429973	However, MM remains incurable, with insufficient rates and duration of response, and progression-free survival (PFS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "MM", "...
PMC9429973	No deaths occurred.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "No", "deaths", "occurred", "." ] } ]
PMC11543885	Transfect the HEK293T cells with NLRP3-APEX2 fusion construct using Lipofectamine 3000 according to manufacturer’s instructions (https://www.thermofisher.com/order/catalog/product/L3000001).	[ { "tags": [ "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transfect", "the...
PMC10728200	The detection indicators of ferroptosis include changes in mitochondrial morphology, lipid ROS levels, Fe levels, and GSH levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "detection", ...
PMC11085211	At the lowest concentration (12.5 µg/mL), a significant reduction (p < 0.01) was observed after FR2-A treatment only; indeed, no effect of FR2 and the other FR2 subfractions was observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The SLR protocol followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "SLR", "protocol", "followed", "PRISMA", "(", ...
PMC11321678	Similarly, overexpression of LHX2 in Group 3 significantly elevated EOMES expression (Figure S8B, Supporting Information).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "overexpression", ...
PMC10587429	However, few orthotopic humanized mouse models are currently reported for bone cancers (13) such as ES (14).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",...
PMC9436459	Benzyl group deprotection finally yielded the two dienophiles S166 and 168.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Benzyl", "group", "deprotection", "finally", "yielded", "the", "two", "dienophiles", "S166"...
PMC9429973	The most frequent co-mutations were DNMT3A (54%), followed by FLT3-ITD (38%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most", "frequent", "co-mutations", ...
PMC11634027	As for endogenous Ds, Ds:V5 protein was localized near apical cell junctions, and at higher magnification often appeared somewhat punctate (Fig. 3B,C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11769516	Initial studies indicate their high neurotoxic activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Initial", "studies", "indicate", "their", "high", "neurotoxic", "activity", "." ] } ]
PMC11435360	Combination therapy with PAG and NaHS abrogated the anti-cancer effects of PAG, partially recovering tumor growth compared to the BBN saline group (p > 0.05, Figure 3A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10654497	We used the R software package “RMS” to integrate data regarding survival time, survival state, and the five characteristics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", ...
PMC9960565	Six different human cell lines were used to assess the cytotoxicity, namely A2780 (ovarian cancer cell line), A2780cisR (cisplatin-resistant ovarian cancer cell line), CACO-2 (colorectal adenocarcinoma cancer cell line), MCF-7 (breast cancer cell line), and BJ (non-cancer cell line) cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "O", "B-CellLine", ...
PMC9429973	On the contrary, in JAK2 mutated patients, the slight increase in oxidative stress can determine the persistence of cells with damaged DNA where the accumulation of mutations promotes the disease progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10055960	Elemental analysis for C48H69N7O24Rh6·3H2O·DCM: Found C, 30.87, H, 4.24, N, 5.08%; calcd.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Elemental", "analysis", "for...
PMC9429973	Moreover, by grouping together these two rearrangements, statistically significant associations were found with several biomarkers of favorable prognosis (low Ki-67, p<0.01; non-blastoid, p<0.05; absence of TP53 aberrations, p<0.05, or KMT2D mutations, p<0.05, and low-risk MIPI, p<0.0001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11283030	Then loss-of-function studies by genetic knockdown or chemical inhibitor were performed to explore the biological function of ACLY in ccRCC pathogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", "loss-of-functio...
PMC8992508	Moreover, many of them were also substrates for P-gp; thus, the use of high doses of chemosensitizers needed to inhibit the activity of ABC transporter produced toxic side effects and showed only limited or no benefits.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8343815	The percentage of cell survival was assessed after the incubation period by means of the MTT assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "percentage", "of", "cell", "survival", ...
PMC9429973	In addition to immune-response genes, MYC, TP63 and several cell proliferation pathway genes were upregulated in RT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", "immune-re...
PMC10391797	We found VPA could upregulate NKG2DL (ULBP1,2,3) on AML cell lines (THP-1, and MV411; figure 3B), which is in accordance with previous studies.13 18 19 VPA upregulates NKG2DL expression on tumor cells and enhances lysis effects on CAR-T cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "...
PMC6222635	In the HSQC spectrum, the signals (69.93, 4.04) and (69.58, 3.43) were observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "HSQC", "s...
PMC11075223	So far, the efficacy varies with doses, and the therapeutic range has been expanded by skillful use of compatibility .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "So", "far", ",", ...
PMC11736898	Based on the reduced relative expression and nuclear localization of VDR in keloid lesions compared with normal skin that were previously reported , we were interested in determining whether keloid keratinocytes can respond to vitamin D treatment in a manner similar to normal keratinocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10443665	The results of the present study revealed that applying APS alone significantly decreased the viability of the cells compared to the negative control groups, however, its impact on decreasing the viability of both sensitive and resistant cells was not considerable compared to the positive controls, which means its combination with MTX couldn't cause any significant alteration in cytotoxicity induced by MTX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9577200

However, the overuse of antibiotics as antibacterial and anticancer treatments can cause side effects and lead to drug-resistant bacteria.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", ...

PMC11615101

The bar graph represents p-65 level after knockdown of α-Taxilin and pure protein induction of TNF-α and α-Taxilin. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bar", "graph", "represents...

PMC11742290

C57/BL6 mice LGR5 KD significantly reduced proliferation and colony formationColorectalColon cancer cell line: CT-26 LGR5 was associated with the maintenance of colon cancer.

[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10969097

Treatments involving breast cancer cells subjected to simultaneous administration of Suillus collinitus methanolic extract and etoposide resulted in greater cell growth inhibition than treatment with each component isolated .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11659921

CCK‐8 solution was applied at the indicated time points.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CCK‐8", "solution", "was", "applied", "at", "the", "indicated", "time", "points", "." ] } ]

PMC9031474

We must then ask: why have none of the aforementioned drimanes or coloratanes made it into the clinic yet?

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "must", "then", "...

PMC11700523

Previous studies have reported that indoxyl sulfate (IS), a major uremic toxin, leads to CKD by inducing tubular and podocyte injury, vascular inflammation, and calcification [3-5].

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11745600

Male (n = 4; A) and female (n = 4; B) Ins1 NOG mice at 8–9 wk of age were used for hSC-islet cell transplantation experiments.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10965680

Neighbor-joining (NJ) tree of the 159 individuals based on the matrix of Hamming genetic distance. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Neighbor-joining", "(", "NJ", ")", "tr...

PMC11787355

Thus, our data suggest a differential but synergistic role for CD4 and CD8 T cells following antigen-specific activation via PTPRZ1 TCR.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", ...

PMC11361748

Analysis of these 209 genes using the Panther statistical overrepresentation test indicated an enrichment for genes involved in neutrophil function and regulation, e.g., Dectin-2 family , GPVI proteins , and cytokine and chemokine production (S7 Table).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11742864

The main challenge is maintaining the balance of good and bad inflammatory effects, so a better understanding on the interactions between ω-3 LCPUFAs and inflammation in lung cancer is critical.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11727000

BRCA2 is tightly correlated with a proliferation gene signature in neuroblastoma across the SEQC, Primary NRC, and TARGET datasets (Pearson R = 0.894, 0.870, and 0.876, respectively; Figure 4E), perhaps explaining the association with these measures of aggressive disease.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11412721

p<0.001, *p<0.05, °p=0.07 by Student’s t-test. (

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PMC11568601

Scale bar = 100 μm.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "100", "μm", "." ] } ]

PMC9368503

Taken together, our data suggest that targeting the PI3K-mTOR pathway may have utility particularly in the context of chemotherapy-resistant synovial sarcoma.

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PMC11730000

In the DOX-treated group, the expression of mTOR protein was notably suppressed.

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PMC11763764

Treatments with FGFR4 inhibitors, FGF401 and fisogatinib, both decreased the viability of OVCAR8 and KRCH31 cells with lower EC50 values compared to carboplatin (Figure 6A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "...

PMC11747949

143B cell phenotype in mono‐culture and coculture with immune cells. (

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PMC11534035

SERPINE1/PAI1 knockdown impacts cell proliferation in A431 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "SERPINE1/PAI1", "knockdown", "impacts", "cell", "proliferation", "in", "A431", "cells", "." ] } ]

PMC11670407

Notably, OTULIN overexpression had no significant effect on the proliferative, invasive, or migratory capacities of osteosarcoma cells with or without cisplatin administration (Fig. 2c, d, g, h, k, l, n).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

However, HSCT indications might vary across countries, and who should not be transplanted is still a matter of debate since HSCT mortality scores lack validation in SCD settings.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8143558

Of these species, only 15 species from 10 families have actually been reported as being used for soaps or shampoos in various communities.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9429973

Summary/Conclusion: Overall, our data provide evidence for B-cell dysregulations mediated by reduced Pax5 levels in the germline of mice and men.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary...

PMC5034105

Briefly, 200 μL of supernatant were used for extraction and the TNA was eluted in 60 μL of AVE buffer.

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PMC9927933

To this end, we arrested cells at the G1/S boundary by double thymidine blockage and then collected cells at various time points after releasing, followed by immunoblotting (IB) for the levels of DEPTOR, along with UBE2C/2S, CDH1, CDC20, and a few known substrates of APC/C E3, including PLK1, cyclin B1, and securin.

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PMC11727000

Spectra were analyzed using MaxQuant software version 1.5.5.1 against the Homo sapiens Uniprot protein sequence database (version July 2016) and GPM cRAP sequences (commonly known protein contaminants).

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PMC9954564

Ultimately, a pool of DNA libraries of up to 96 samples was diluted to 16 pM and inserted as input for sequencing using the MiSeq Reagent Kit V3 (600 cycles) in the MiSeq Personal Sequencer (Illumina Inc., San Diego, CA, USA).

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PMC11402217

Given the significant involvement of DKK1 and the Wnt/β-catenin signaling pathway in bone-destructive diseases, it is reasonable to hypothesize that DKK1 may act as an oncogene in OS.

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PMC7171147

Peptide fractions were separated using a 50 cm EASY-Spray analytical column on an EASY nLC 1000 ultraperformance LC system and analyzed by an LTQ Orbitrap Elite mass spectrometer (Thermo Scientific).

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PMC9429973

Thymoglobulin (rabbit ATG, Genzyme, dose range 4.5 -11.25 mg/kg) was the T cell depletion used in all conditioning regimens except for Fanconi anaemia (FA), where alemtuzumab 0.3 and 0.9 mg/kg was used for Sib and unrelated transplantation, respectively.

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PMC8922418

Therefore, the HIV-1 reservoir can be converted to noninfectious proviral DNA by key amino acid mutations that are important for viral infectivity.

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PMC11216402

The 11,312 tissue-specific genes (described above) were used to calculate the correlation.

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PMC11747467

Of note, we selected ART as the combination drug with RC48 rather than BP-1-102 and Stattic.

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PMC8270637

Summary of the mechanism by which TGF-β1 up-regulates the expression of PD-1 and CTLA-4 in T cells.

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PMC11271800

It is important to note that imatinib treatment can be a “double-edged sword” for patients.

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PMC10196713

Cells were treated with 1 µM penicillamine 48 h, thereafter cells were incubated in WST working solution and Enzyme working solution at 37°C for 20 min.

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PMC11424574

ERK1/2 is involved in MTA2-mediated regulation of human osteosarcoma cell migration and invasion. (

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PMC11705067

Further studies demonstrated that FDX1 expression was positively correlated with infiltration levels of eosinophils and mast cells (r = 0.168, P < 0.001), neutrophils (r = 0.172, P < 0.001), but negatively correlated with cytotoxic cells (r = -0.239, P < 0.001) and TReg (r = -0.314, P < 0.001), while there was no significant correlation with B cells (r = -0.073, P < 0.090).

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PMC11590005

Values in bold indicate statistically significant difference.

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PMC10291556

COX isoform COX-2 is frequently expressed in many types of cancer and induces CSC-like activity, promoting apoptotic resistance, proliferation, angiogenesis, inflammation, invasion, and metastasis of cancer cells.

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PMC3931643

There was no detectable 4EBP1 mRNA in VAL cells in contrast to the OCI-LY1 and OCI-LY7 cell lines (Fig. S3).

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PMC11699465

TMEM199 regulate PD-L1 mRNA level (A) Relative TMEM199 expression level in TMEM199 knock out cells with different oligos (∗, p < 0.05; ∗∗, p < 0.01; ∗∗∗, p < 0.001).

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PMC2777936

This observation was made consistently with the two independent siRNA sequences targeting FZD7 and is viewed to be a consequence of FZD7 repression.

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PMC11049548

For example, concerning migration, A2780 behaved similarly to PEO1, PEO4, and FUOV1, which are HGSOC cell lines; COV318 cells, instead, are genomically classified as a high-grade serous cell line but behave similarly to non-serous cell lines.

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PMC11708541

Antitrypanosomal therapy of revived diseases in immunosuppressed patients results in declined intensity of parasitemia.

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PMC11699042

cDNA was fragmented, and TruSeq-Adapters ligated with the NEBNext® Ultra™ II FS DNA Library Prep Kit for Illumina® (NEB), and 3’-end-fragments were finally amplified using primers with Illumina P5 and P7 overhangs.

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PMC11755519

Subsequent results confirmed that VEGFR3 expression was significantly upregulated in HLECs with tumor cell exosomes.

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PMC11314247

no. 1620177; Bio-Rad Laboratories, Inc.).

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PMC11337594

The results showed that the inhibitory effect of TER on Cyclin A2 expression increased with the increase of TER concentration and was alleviated after p53 knockout (Fig. 4D).

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PMC11088135

Fig. 9LncRNA NUTM2A-AS1 positively regulates of YAP1 expression in U251 cells.

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PMC3765139

CD133 expression (brown spots, black arrows) in different tissue samples: A: normal skin section showing a few brown spots.

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PMC11607321

Taken together, our findings suggest a broad association of 1-methylnicotinamide and EMT across hundreds of cancer cell lines with a potential role in drug resistance.

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PMC10551595

Cys124 was previously introduced as a critical amino acid that plays a pivotal role in the restoration of TP53 function. ,

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PMC9841531

Yellow crystals; yield: 65%; melting point: 192–194 °C; FTIR (cm): 3292.94 (NH), 2214.52 (CN), 1721.24 (C=O), 1673.19 (C=O), 1593.89 (C=C); H NMR (400 MHz, DMSO-d6) δ 10.56 (s, 1H), 8.67 (s, 1H), 8.58 (s, 1H), 8.08–7.84 (m, 1H), 7.61 (dd, J = 8.1, 5.3 Hz, 3H), 7.33 (m, 4H), 7.19–6.87 (m, 1H), 5.35 (s, 2H), 3.84 (s, 3H); MS (m/z) calculated for C21H17N3O3: 359.127, found: 377.25 [M + H2O] and 382.150 [M + Na]; purity (HPLC): 98%.

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PMC11704834

It is noteworthy that TLE1 has been shown to transcriptionally upregulate Bcl-2 expression (21).

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PMC11240052

Several studies have shown one of the main roles of circRNAs is the sponging of miRNAs and via this function participate in circRNA, miRNA, and target gene networks for regulating cancer pathogenesis (34–37).

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PMC11599565

In fact, this phenomenon has been observed in both normal and malignant cells.

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PMC11750712

Whole blood was extracted from each cone and diluted to 50 ml with sterile PBS.

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PMC11532793

The distributional assumptions made by edgeR have been described by Chen et al. (14).

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PMC3730428

REN cell line was donated by Prof. Steven M. Albelda, University of Pennslyvania Medical center, Philadelphia, USA.

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PMC11705862

The quantification is shown in (E). (

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PMC9672323

To conclude, our study adds to the growing literature on the anti-cancer properties of NSAIDs.

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PMC9786247

Deploying more markers than were used in our study may also help to better link genotypes to phenotypes, even though more isolates would have to be included to represent each subcluster in sufficient numbers to confirm correlations.

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PMC11380329

So far, there is lack of methods recommended for screening and early diagnosis of this disease .

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PMC11216402

To calculate the CN burden in GC cell lines, we converted the CNVkit output to a GISTIC-like integer score (ranging from −2 to +2; described above).

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PMC11674891

The role of GRPR in cell lines with other driver mutations, including EGFR, needs to be discovered in future studies.

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PMC11536589

The pseudo-time trajectories analysis of all KPC cells. (

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PMC9583612

SeekOps provided a summary report of measured emissions and wind-roses with detailed notes at each site.

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PMC11310713

Coupling with the previous results of recovery of ovarian sex hormone level in GTB-injected rats similar to ovary-intact rats, this indicates that the injected GTBs induced a balanced HPO axis through the normal action of the negative feedback system, leading to the restoration of endocrine function.

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PMC9261184

The natural gas supply chain is a key emission source, where methane emissions from liquefied natural gas (LNG) shipping have until now not been directly measured.

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PMC11661040

Additionally, there was a notable decrease in Cyclin D expression levels observed in the CGREF1 knockdown group when compared to the control group (Fig. 7D, E).

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PMC10849234

Error bars represent the standard deviation and statistical comparison was done using a two-tailed student’s t-test.

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PMC9429973

However, MM remains incurable, with insufficient rates and duration of response, and progression-free survival (PFS).

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PMC9429973

No deaths occurred.

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PMC11543885

Transfect the HEK293T cells with NLRP3-APEX2 fusion construct using Lipofectamine 3000 according to manufacturer’s instructions (https://www.thermofisher.com/order/catalog/product/L3000001).

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PMC10728200

The detection indicators of ferroptosis include changes in mitochondrial morphology, lipid ROS levels, Fe levels, and GSH levels.

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PMC11085211

At the lowest concentration (12.5 µg/mL), a significant reduction (p < 0.01) was observed after FR2-A treatment only; indeed, no effect of FR2 and the other FR2 subfractions was observed.

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PMC9429973

The SLR protocol followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines.

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PMC11321678

Similarly, overexpression of LHX2 in Group 3 significantly elevated EOMES expression (Figure S8B, Supporting Information).

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PMC10587429

However, few orthotopic humanized mouse models are currently reported for bone cancers (13) such as ES (14).

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PMC9436459

Benzyl group deprotection finally yielded the two dienophiles S166 and 168.

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PMC9429973

The most frequent co-mutations were DNMT3A (54%), followed by FLT3-ITD (38%).

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PMC11634027

As for endogenous Ds, Ds:V5 protein was localized near apical cell junctions, and at higher magnification often appeared somewhat punctate (Fig. 3B,C).

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PMC11769516

Initial studies indicate their high neurotoxic activity.

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PMC11435360

Combination therapy with PAG and NaHS abrogated the anti-cancer effects of PAG, partially recovering tumor growth compared to the BBN saline group (p > 0.05, Figure 3A).

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PMC10654497

We used the R software package “RMS” to integrate data regarding survival time, survival state, and the five characteristics.

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PMC9960565

Six different human cell lines were used to assess the cytotoxicity, namely A2780 (ovarian cancer cell line), A2780cisR (cisplatin-resistant ovarian cancer cell line), CACO-2 (colorectal adenocarcinoma cancer cell line), MCF-7 (breast cancer cell line), and BJ (non-cancer cell line) cells.

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PMC9429973

On the contrary, in JAK2 mutated patients, the slight increase in oxidative stress can determine the persistence of cells with damaged DNA where the accumulation of mutations promotes the disease progression.

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PMC10055960

Elemental analysis for C48H69N7O24Rh6·3H2O·DCM: Found C, 30.87, H, 4.24, N, 5.08%; calcd.

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PMC9429973

Moreover, by grouping together these two rearrangements, statistically significant associations were found with several biomarkers of favorable prognosis (low Ki-67, p<0.01; non-blastoid, p<0.05; absence of TP53 aberrations, p<0.05, or KMT2D mutations, p<0.05, and low-risk MIPI, p<0.0001).

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PMC11283030

Then loss-of-function studies by genetic knockdown or chemical inhibitor were performed to explore the biological function of ACLY in ccRCC pathogenesis.

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PMC8992508

Moreover, many of them were also substrates for P-gp; thus, the use of high doses of chemosensitizers needed to inhibit the activity of ABC transporter produced toxic side effects and showed only limited or no benefits.

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PMC8343815

The percentage of cell survival was assessed after the incubation period by means of the MTT assay.

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PMC9429973

In addition to immune-response genes, MYC, TP63 and several cell proliferation pathway genes were upregulated in RT.

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PMC10391797

We found VPA could upregulate NKG2DL (ULBP1,2,3) on AML cell lines (THP-1, and MV411; figure 3B), which is in accordance with previous studies.13 18 19 VPA upregulates NKG2DL expression on tumor cells and enhances lysis effects on CAR-T cells. (

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PMC6222635

In the HSQC spectrum, the signals (69.93, 4.04) and (69.58, 3.43) were observed.

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PMC11075223

So far, the efficacy varies with doses, and the therapeutic range has been expanded by skillful use of compatibility .

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PMC11736898

Based on the reduced relative expression and nuclear localization of VDR in keloid lesions compared with normal skin that were previously reported , we were interested in determining whether keloid keratinocytes can respond to vitamin D treatment in a manner similar to normal keratinocytes.

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PMC10443665

The results of the present study revealed that applying APS alone significantly decreased the viability of the cells compared to the negative control groups, however, its impact on decreasing the viability of both sensitive and resistant cells was not considerable compared to the positive controls, which means its combination with MTX couldn't cause any significant alteration in cytotoxicity induced by MTX.

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