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OTAR3088
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BioData-CellLine_annotated

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PMC4360730
Biocurators search for the most specific possible term available in a relevant branch of the ontology.
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PMC11625890
My interest in neurological research stemmed from my sister's experience of managing a chronic condition, with little success from medication My interest in neurological research stemmed from my sister's experience of managing a chronic condition, with little success from medication How would you explain the main finding of your paper?
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PMC8584319
Therefore, contrary to the reports that constitutive ERK1/2 activity and repression of p38 contribute to cell survival through expression of the proto-oncogene transcriptional regulators YAP1 and c-MYC , the simultaneous activation of ERK1/2 and p38 observed in our study appears to contribute to cell survival.
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PMC11583010
The scoring procedure was as follows: (i) The proportion of cells stained positively was estimated, and a score from 0 to 4 was assigned for each field (0 = 0%–5%; 1 = 5%–25%; 2 = 25%–50%; 3 = 50%–75%; and 4 = 75%–100%); (ii) The staining intensity was scored as 0, 1, 2, or 3 corresponding to the presence of negative, weak, intermediate, and strong brown staining, respectively.
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PMC3675084
Mitotic catastrophe is another form of cell death pathway that is caused by abnormal mitosis and/or irreparable chromosomal damage , , , .
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PMC8041314
Cyclosporine A (10 μM) and Ko143 [(3S,6S,12aS)-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1′,2′:1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester; compound 34; 10 μM] have been chosen as positive controls for ABCB1 and ABCC1 as well as ABCG2, respectively, defining 100% inhibition.
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PMC11541241
Previous studies have implicated the interaction between TOR and MAPK pathway (Madrid et al., 2016).
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PMC10852540
It is especially found in high concentrations in oregano, rosemary, lemon balm, sage, and marigold.
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PMC10877303
The 3D structure of the listed phytochemicals was retrieved from the PubChem database .
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PMC11684269
Specifically, itaconate can inhibit glycolysis and OXPHOS, which leads to decreased levels of certain metabolites, termed S-adenosyl-L-methionine/S-adenosylhomocysteine(SAM/SAH) ratio and 2-hydroxyglutarate (2-HG).
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PMC10142392
Nanotechnologies draw inspiration from this biological phenomenon, using molecular blocks to self-assemble into organized structures applicable to drug administration and biomedicine, sensors, circuits, and devices .
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PMC5035325
In fact, more than 50 % of co-expression of EGFR and NeuGcGM3 from 15 histological subtypes was observed.
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PMC11583010
C, NMRI nude mice (n = 8/group) were subcutaneously implanted with tumor fragments from bladder cancer PDX B521.
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PMC11635087
To date, there has been no report of the transfer of isolated chloroplasts into a heterologous host cell that resulted in detectable photosynthesis in the host cell.
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PMC8998437
Low CCR2 mRNA expression levels we detected in three BL cell lines, with the following values normalized to TBP mRNA expression: 0.022 ± 0.001 in BL18; 0.040 ± 0.006 in Mutu cl.99; and 0.066 ± 0.002 in Jijoye P79.
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PMC10976516
Moreno et al.ICOVIR-5, strain analog to ICOVIR-15IntraperitonealMurine bone marrow-derived MSCsMSCs loaded with ICOVIR-5 (Celyvir therapy), i.p.
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PMC9429973
Blinatumomab also showed a strong benefit for the secondary endpoint of OS (at 4 years: 77% vs 49%, stratified log-rank p=0.002, HR: 0.34, 95% CI: 0.17-0.69).
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PMC11806818
Expectedly, dual-mode sensors will not only mitigate false positive signals associated with variations in detection conditions and operations, but also extend the detection range and improve the sensitivity.
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PMC11707577
Cells were washed to remove excess M13EGFR(TNP) and stained for 15 min with Hoechst 33342 (1 µg mL).
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PMC11655498
BMLF1 activates the UPR (unfolded protein response) sensor ATF6 by initiating the proteolytic cleavage, which transcriptionally activates the GRP78 promoter, a central regulator in the UPR, via ER stress response elements.
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PMC11422497
Following a 48-hour incubation period, luciferase reporter assays were conducted using a dual luciferase assay kit (E1960, Promega, Beijing).
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PMC10253553
We hypothesize that RICTOR and mTORC2-mediated phosphorylation of NDRG1 (Thr346) promotes the viability of ccRCC cells.
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PMC9429973
The number of HMA cycles received before HMA-F was 6 (range: 1-13) in t-MDS and 5 (range: 1-23) in de novo MDS.
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PMC11670407
Fig. 8OTULIN regulated the ubiquitin levels of GPX4 and conferred resistance to cisplatin in osteosarcoma.
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PMC11509309
Several bromotyrosine compounds were also shown to be able to inhibit cancer proliferation, invasion, and migration .
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PMC11453346
Here, we adapted the BioID approach to identify novel H6PD interacting partners in the ER.
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PMC7841067
Li and his team showed that AKAP4 mRNA and protein levels were obviously upregulated in esophageal cancer tissues, silencing AKAP4 inhibited cell growth in vitro and suppressing tumor growth in a xenograft model7.
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PMC9429973
Study-level comparisons of average HbF levels of patients that experienced an adverse outcome vs. those that did not were described in 17 analyses.
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PMC11724582
In addition, TGF-β1, an important member of the TGF-β family, has been shown to be a major inducer of EMT and promotes the development of NSCLC.
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PMC9429973
The study enrolled children (aged ≥ 12 years) and adults, all with genetically confirmed CXCR4 variants consisting of both nonsense and frameshift mutations.
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PMC6461034
Centrifuge 30 s at 2,000 × g, transfer supernatant (eluate 1) to a 1.5‐ml LoBind Eppendorf tube.
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PMC3164356
Hence, the property of resistance to viral infection demonstrated by CHO cells further contributes to their preferred choice as hosts for therapeutic protein production.
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PMC10729469
p < 0.001, n = 3.
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PMC11574029
It has high incidence and mortality rates, with an estimated 500,000 new cases and 200,000 deaths globally [1–4].
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PMC11748363
Testing was performed by Microplate Alamar Blue Assay (MABA) (Franzblau et al. 1998) and according to EUCAST protocol (Schön et al. 2020), where results were expressed as MIC in μg/mL in comparison with INH, RIF, and ciprofloxacin (CIP) as standards.
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PMC11742231
It is important to note that ablation studies are typically conducted in conjunction with other experiments to provide a more comprehensive understanding of the model’s behavior.
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PMC11612626
Treatment of patient CD138 cells with compound A followed by co-culture with autologous T cells increased myeloma cell death (Fig. 7C).
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PMC9429973
Methods: SAA treated with IST including horse antithymocyte globulin (h-ATG), cyclosporine (CSA), and eltrombopag (EPAG) at the National Institute of Health with confirmation of SARS-CoV-2 vaccination between January and November 2021 were included.
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PMC9429973
Twenty patients (57%) were referred in complete remission (CR).
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PMC10142392
In this study, PCL nanoparticles loaded with curcumin (with a diameter of about 390 nm) were prepared using the solvent emulsification and evaporation technique.
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PMC11412721
However, the potential role of p53 isoforms with an alternative C-terminus was not analyzed in vivo.
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PMC11770199
The syncytia then continued to grow as more cell nuclei gathered into the central region of the syncytia, reaching the maximum size at around 16 h after transfection.
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PMC11347429
Manhattan plot of cis-eQTL analysis.
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PMC11300639
Lysate proteins were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), transferred to a 0.45 μm polyvinylidene fluoride membrane (Millipore, Billerica).
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PMC11525293
Second, they support a protective role for Thal against SARS-CoV-2 viral infection and explain the molecular details of how this compound exerts its functions, potentially making it a valuable option in the management of SARS-CoV-2 or other ACE2-dependent infections.
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PMC10936243
The questions were focused on basic cat post-operative management and the clinicians’ experience in terms of the provision of good care.
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PMC11723947
In this system, and in the absence of suppressive cells, a strong xenogeneic Th1 response develops in the weeks following injection.
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PMC11612794
GFP-Dsn1 levels were further decreased in the CENP-T-immunoprecipitated fraction of CENP-C/CENP-T/Dsn1 cells, compared to those in the CENP-C/CENP-T/Dsn1 or CENP-C/CENP-T/Dsn1 cells (Figure 6C).
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PMC11461874
Then, the cell lysates were immunoprecipitated by using anti-Flag antibody and immunoprecipitates were subjected to immunoblotting.
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PMC11476264
Transwell chamber membranes (24-well; 8 μM, Costar, Costar, Corning, NY, USA, #3422) were coated with fibronectin (Sigma-Aldrich).
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PMC7868205
Further enduring studies using several models can indicate the specific modes of toxicity.13–16 Human embryonic kidney 293 (HEK-293) cells are one among the widely used standards for normal human cells.
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PMC10914904
However, changes in the expression of vtRNAs have been associated with pathological processes that activate proinflammatory pathways, which influence cellular events such as differentiation, aging, autophagy, apoptosis, and drug resistance in cancer cells.
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PMC10809689
Asterisks represent statistical significance (* p < 0.05, ** p < 0.001, ***p < 0.0001).
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PMC11477621
Starting from 13 (43 mg, 0.15 mmol), the title compound was obtained following the procedure previously described for compound 11.
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PMC11799620
The HepG2 and HEK293 cells were cultivated in MEM and DMEM-F12 medium, respectively containing RCS (10%), L-glutamine (1%), and gentamycin sulfate (50 µg/ml).
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PMC4112127
The majority (10/12, 83%) were women and most (10/12) had intrahepatic tumors.
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PMC9910796
Western blot analysis demonstrated that pEP84R-Flag co-immunoprecipitated with pp220NT-V5 (Fig 7C).
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PMC9429973
Due to early relapse and no target therapy available, AZA was administered.
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PMC11089031
To compare the expression of ZNF692 between paired tumor and adjacent normal tissues, we queried the Tumor Node Metastasis (TNM) plotter (https://www.tnmplot.com) website .
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PMC11720808
Furthermore, auto-K63 ubiquitination of TRAF6 is essential for the signal transduction of TLR4/NF-κB,34,35 but whether the interaction of SCU and TLR4 affects TRAF6 K63 ubiquitination needs to be further explored.
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PMC9429973
All the T315I patients had a previous ponatinib exposure.
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PMC11361748
P < 0.0001.
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PMC11155445
Free radical scavenging activity of the compound (44) was moderate (55.62%) compared to vitamin-C (94.90%) at 100 μg mL. In silico investigation of compound (44) revealed hydrogen bonding interactions in ligand–protein complexes during compound (44) binding with RNA, and found as a potent groove binder with DNA (Fig. 5).
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PMC9780037
On the other hand, lysine N-homocysteinylation could be proapoptotic.
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PMC9429973
Our category of highly suspected B-NHL with plasmacytic differentiation is literary sign as “AL amyloidosis with a localized B-cell neoplasia of undetermined significance” or as “AL amyloidosis with a an associated predominant kappa or lambda light chain expressing plasma cell population without evidence for clonality”.
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PMC11803210
Expression of genes associated with estrogen signaling and epithelial-to-mesenchymal transition were upregulated in MCF-7 cells treated with naringenin (Table 1, Fig. 2A).Fig.
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PMC9429973
A median duration of hospitalization was 25 days (range, 14-72).
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PMC9429973
However, Higher BMI is associated with decreased overall survival (OS) (95% CI, p=0.004).
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PMC9429973
We have also shown that decitabine and tolinapant as single agent induced necroptosis in mouse TCL cell lines with the activation of the RIPK1/RIPK3/MLKL necroptosis pathway.
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PMC7351993
For all particles detected in the GFP channel, each particle was identified from the ratio of the fluorescence intensities obtained in the GFP and TRITC channels.
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PMC11474209
This results in neuroinflammation due to the activation of microglia and astrocytes, highlighting a serious risk to brain health and underscoring the potential dangers of MC-LR to human neurological systems.
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PMC11240052
Expression ratio of circ-0008285 after transfection with inh- circ-0008285 in A2780 cell line. (
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PMC8922418
To consider safety in the clinical use of CRISPR-based gene editing for HIV/AIDS therapy, some caveats must be addressed before widespread use.
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PMC11754436
Immunohistochemistry.
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PMC11585565
The p.(Thr495Ile) CNNM4 protein impairs Mg export activity, ATP binding, and protein homodimerization.
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PMC5308810
Both cell lines were maintained in RPMI 1640 media supplemented with 10% (w/v) FBS (HyClone, South Logan, UT) and 1% (w/v) antibiotics (penicillin-streptomycin) at 37°C in a humidified atmosphere of 5% CO2.
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PMC11607638
Adult mosquitoes showed similar body weights among the four groups, but blood meal size decreased markedly in the three SK‐injected groups when compared with DEPC water control.
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PMC6222726
None of the evaluated compounds had statistically significant anti-proliferative effects with respect to dimethyl sulfoxide (DMSO) control on LS 180, A549, and ARPE cell lines.
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PMC9429973
The primary endpoint was investigator-assessed PFS; secondary endpoints included time-to-next anti-lymphoma treatment (TTNLT), overall survival (OS) and incidence of adverse events (AEs).
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PMC11487720
Our approach, which involved domain mapping by utilizing Förster resonance energy transfer (FRET) imaging, yeast two-hybrid analysis, and cell death assays, led to the discovery of a previously unknown molecular complex that controls UV/cold shock-mediated cell death at low temperatures (22 °C and below) for BCD and 37 °C for apoptosis.
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PMC11502962
PD-1 expression by tumor-associated macrophages has been linked to inhibition of phagocytosis and immunity (29).
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PMC11591038
The hyperphosphorylation of tau proteins not only impairs the biological functions, with resultant compromised microtubule structures and disturbed axonal transport, but also causes aberrant aggregation leading to neuronal damage .
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PMC11739504
Both serum withdrawal 6 h and 24 h under silence Kat2b had no significant difference between Arl13b and acetylated α-tubulin, but the intensity of acetylated α-tubulin itself and Arl13b were reduced.
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PMC9429973
In non-ICU patients with AL and LPD younger than 60 years, the mortality rate was 0%.
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PMC11770746
In an attempt to further improve efficacy and reduce toxicity, we also encapsulated extremely cytotoxic cisPt(Pac)(OH) into micelles and evaluated its efficacy.
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PMC11222184
IGFBP7 promotes tumor cell proliferation, angiogenesis and epithelial-mesenchymal transition .
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PMC11740907
An intense peak was also found in spectra of P5W30-BW-SLNs in finger print region at 1084.65 cm which was due to C-O stretching movements while another peak with sharp edges was at 728.69 cm which may be because of bending vibrations.
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PMC9429973
It was found that patients without progression at the time of inclusion in the study in the presence of mutations in the NOTCH1 gene had a statistically significantly shorter progression-free survival (mean 33.4 months (95% CI [22.0-44.8]) compared with patients without mutations (59.2 months (95% CI [54.1–64.3]) (p=0.018), which indicates the association of NOTCH1 mutations with a poor prognosis for disease progression in patients with CLL.
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PMC11046454
White arrowhead points to the IS, the nanoscale gap between T cells and antigen presenting cells.
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PMC4112127
Of the genes in the panel, three novel genes (CDO1, DCLK1, and ZSCAN18) were found to be frequently methylated in CC in addition to SFRP1, which has been previously reported .
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PMC11186948
To date, two other de novo variants linked to syndromic phenotypic manifestations were reported in HDAC2 (Martínez et al. 2017; Wagner et al. 2019).
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PMC11047729
After being carried to the cell by transthyretin (TTR) or retinol-binding protein (RBP), retinol crosses the cell membrane and bonds to cellular retinol-binding protein (CRBP).
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PMC6948907
Genistein (GE), belongs to flavonoids, has an inhibitory effect on tumorigenesis through epigenetic regulations.
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PMC6835428
The authors studied particles of PVTC or PVTC–POEGMA.
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PMC7022782
The mean diameter increased with the increase of ICG concentration (p < 0.05).
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PMC11700340
standard error; , least significant difference; statistically significant differences are shown by variations in capital letters within the same column, whereas variations in lowercase letters within the same rows also indicate statistically significant differences. *,
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PMC11683130
This structure consists of 8 ~ 9 α helices (hA ~ hI) and 3 β sheets (A-β, B-β, C-β) (21) ( Figure 1 ).
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PMC8557138
A summary of vascularized tissue-engineered models developed in recent years using different biomaterials along with their applications in various fields of biology is summarized in Table 2.Nevertheless, there are many interesting but ignored aspects that could raise the level of tissue-engineered tumor vascular grafts for instance by assisting in pre-vascularization of the developed tumor grafts, mechanical stimulation of bioprinted constructs that could help control the branching/sprouting of the blood vessel.
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PMC11585254
Cells were pretreated with vehicle or CXCL13 (10 nM) for 1 hour at 37°C before challenging with varying doses of CXCL13 in the presence of forskolin (FSK).
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PMC11742431
Similarly, we analyzed the expression level of Furin and showed that Furin was highly expressed in bladder cancer and was higher than controls at all stages (Figure 2E,F).
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