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PMC11012313
These findings implicate the importance of LMP2A in promoting B cell lymphoma survival by increasing ATP generation and identifying potential pharmaceutical targets to treat EBV-associated tumors.
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PMC10713411
The depletion of B cells therapeutically enhanced the responses of antitumor immunity in certain tumors by reducing the IL-10 secretion of B cells .
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PMC9964635
Yield 75%, m.p 100–102 °C.
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PMC10873328
And HIF-2α binding site was found in the promoter region of TGFBI, indicating HIF-2α could directly promote TGFBI transcription.
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PMC11394386
Additionally, we discovered that HIF1α directly induces HOTAIR transcription, which in turn leads to the epigenetic silencing of the PTEN promoter via DNMT1.
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PMC9429973
There was no statistically significant difference between the two groups in terms of age, gender, donor type and stem cell source.
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PMC10996034
The mechanism of Taxol involves binding with the 31-amino acid N-terminal from the β-microtubule protein subunit to induce microtubule stability and prevent its depolymerization, generating G2/M phase accumulation in tumor cells, thus inhibiting mitosis and cell proliferation, and promoting cell apoptosis (10–12).
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PMC11777207
Male and female mice were used in these studies with no observed gender differences.
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PMC11240448
BMRA-reconstructed local response matrices were used for further analysis and model development.
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PMC11502327
TME is a dynamic and complex acid-hypoxic system composed of malignant tumor cells, tumor-infiltrating immune cells, endothelial cells, extracellular matrix, vasculature, cytokines and chemokines.
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PMC9429973
Five variants (25.0%) showed a VAF<10%, whereas, in the 15 others identified (75.0%), the clone was dominant.
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PMC11621493
The enzyme also hydrolyzed sn-1-acyl lyso-phospholipids, whereby Ca strongly enhanced the degradation of LPE (Fig. 1C).
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PMC9429973
Phosphorylation of STAT3 and STAT5 of JAK/STAT pathway was studied by western blot.
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PMC11190538
Infectivity was lowered by 56 % at peak non-cytotoxic dosages of C-phycocyanin.
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PMC11788920
To quantify the relative transcription events that reach full length, we plotted the Cy5/Cy3 signal ratio at saturation in Fig. 3E and H for the WT and the GQ-Mut constructs, respectively.
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PMC9429973
QoL was similar in both arms after randomization.
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PMC11224206
Quantify the contribution of the factors which determine thermal homeostasis during the various stages of preimplantation development.
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PMC10551595
Values are the mean ± SEM of two independent experiments and each experiment was performed in duplicate. **
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PMC11092382
K. Rosenthal.
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PMC10729469
Fixed brains were sectioned coronally with a cryostat (Thermo Fisher Scientific), and 30 μm sections were serially collected and stored at − 80 °C.
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PMC11802855
The filtered suspension was transferred into a culture flask with a complete medium, where it was allowed to settle for 4 h to remove non-adherent cells.
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PMC9429973
CR rate was 73%.
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PMC11650848
A human placental dataset, GSE56781 , was used to assess transcript variants of the ZFP57 gene using GEOquery (2.46.15).
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PMC11267036
Twelve male BALB/c nude mice (6 weeks, 20 ± 2 g) used in this study were supplied by Shanghai SLAC Laboratory Animal (Shanghai, China).
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PMC9429973
Image: Summary/Conclusion: While this analysis was limited by the availability of aggregate data from DREAMM-2, which may influence the outcomes of interest, results suggest that one-time treatment with ide-cel offers improved HRQoL vs BM across the QLQ-C30 pain, fatigue, and global health status/QoL domains, as well as the QLQ-MY20 pain domain.
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PMC9220170
Thus, SELENOM can serve as a molecular biomarker of Se status and is involved in the regulation of human neurogenerative diseases .
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PMC9429973
Figure 1D) Image: Summary/Conclusion: Mutations in ASXL1 are associated with delayed responses and worse outcomes when detected in chronic phase CML.
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PMC5673060
Venn diagrams show distribution of phosphorylation sites across three biological replicates (R1, R2 and R3) in PazR/A204 and DasR/A204 experiments.
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PMC11377827
USP43 mixed KO population is shown in Fig. EV4A. (
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PMC11657744
A two-way ANOVA test followed by Dunnett’s multiple comparisons was performed. *,
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PMC5673955
Normalized hTERT expression at 9‐h time‐point decreased to 0.18 ± 0.05 × 10 in Jurkat cells and 0.17 ± 0.08 × 10 in CD4 cells.
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PMC9646302
In our study, we found that LAPTM5 promoted proliferation, migration, and invasion of ccRCC cells in vitro and promoted tumor growth and survival in vivo; however, the underlying mechanisms remain unknown.
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PMC10243817
Overall, these data indicate that TGF-βR3 is a TGF-β2–specific coreceptor and indispensable for TGF-β2 signaling in nasal epithelial cells.
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PMC9436459
As shown in Scheme 9, base-mediated Claisen-Schmidt condensation of the MOM-protected aldehyde S73 and ketone S74 readily produced 2' hydroxychalcone S75.
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PMC10443665
Concentration-dependent growth inhibition was induced by tragacanthin and bassorin on the leukemic cells (CCRF-CEM, CCRF-CEM/MTX, and CCRF-CEM/R) when applied alone or in combination with MTX at 0.1 and 0.6 μM, respectively.
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PMC11588008
A total of 24 transwell chambers are laid, with 2,500 cells all laid.
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PMC8609870
According to the quality of the total RNA from 3 patients with RSA and 3 normal abortion personnel (Additional file 1: Figure S1), the transcriptome sequencing showed that 1008 DELs (523 upregulated and 485 downregulated), 475 DEGs (201 upregulated and 274 downregulated) and 37 DEMs (15 upregulated and 22 downregulated), which were shown in the heat map (Fig. 1) and the volcano map (Additional file 3: Figure S3, Additional file 4: Figure S4 and Additional file 5: Figure S5).
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PMC11679033
DNA damage indicates that CIT may induce genome instability through indirect mechanisms rather than direct DNA interaction, with evidence of potential aneuploidic effects from the CBMN Cyt Assay.
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PMC11670954
These findings indicated that at LPS concentrations between 2 and 10 μg/mL, BA played a protective role in maintaining the epithelial barrier.
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PMC9341513
Simulated Hi-C data is shown below a map of the genes within the rearranged CCND1 locus as found in the U266 cell line (hg19_u266 genome; a region encompassing the CCND1 and FGF19-TADs is shown).
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PMC9429973
The 2-year PFS rate and 5-year OS rate were 55% (95% CI 36-84) and 71% (95% CI 49-100), respectively for patients treated with BTKi at 2L, and 42% (95% CI 28-63) and 46% (95% CI 32-68), respectively, for those treated with BR.
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PMC11803210
Differentially expressed genes included in the analysis were significantly altered with |log2FC| > 1 and adjusted p-value < 0.05 .
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PMC9065483
Together, these results provide evidence to support that vanadate facilitates increased NF-κB signaling favoring a proinflammatory profile in treated tumor cells by regulating IκB-ɑ through EGFR activation.
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PMC6889484
Umbilical cord blood (UCB) CD34 cells were isolated and verified as described previously from cord blood generously donated from the Cleveland Cord Blood Center (Cleveland, OH, USA).
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PMC10919056
The RNA sequencing data, clinical trait data, pan-cancer data and simple nucleotide variation data of ccRCC were obtained from The Cancer Genome Atlas (TCGA) database (https://portal.gdc.cancer.gov/); Microarray data (GSE29609, GSE95425, GSE73731) were retrieved from Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo/).
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PMC11739504
Representative images displayed accumulation of Smo within primary cilia when treated garcinol 6 h before SAG treatment and serum withdrawal 24 h, and right graph showed mean of fluorescence intensity within cilia.
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PMC11768281
In the final phase of T-cell activation, effector T cells (Teff) perform cytotoxic functions and secrete cytokines to combat Plasmodium, reducing parasitemia until the contraction phase begins.
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PMC10317042
D, CCS cells were treated with 0, 0.3, or 3.0 μmol/L vorinostat for 24 hours.
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PMC9429973
14-day dosing in mice and dogs demonstrated excellent tolerability at therapeutic doses.
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PMC10253973
Subsequently, it disrupts formation of the NCp7/SL2 complex by compound 43 (Figure 16) or 17 (Figure 6), which was found to be the most potent inhibitor in terms of concentration for compound 43 (Figure 16) .
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PMC11547917
The Caco-2 cells did not show any morphological differences upon exposure to the Aristolochia extract or Trolox, with the effect being similar (Figure 2C,D).
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PMC11655536
As shown in Fig. 2E, Caspase-3/7 positive cells were detected in 45.4% of RPMI-8226 cells and 10.5% in U266 at 10 µM, and the activity further increased to 83.1% of RPMI-8226 cells and 25.5% in U266 at 20 µM. Similar results were obtained for MM.1S cells (Fig. S2A, B).
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PMC11352311
Initially, network pharmacology was employed to predict the interaction targets of esculin and RCC, as well as the biological functions of these targets.
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PMC11742431
Weighing nude mice in the control and experimental groups during treatment. (
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PMC10114490
diHLC-T-based model showed an area under the ROC Curve (AUC) mean value above 0.8 while HepG2 cells model AUC mean value = 0.73 (Fig. 6B).
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PMC11075223
The Cimicifugae Rhizoma samples were classified into two groups by screening chemical markers including caffeic acid, FA, IFA, cimifugin, cimicifugic acid A and cimicifugic acid B based on UPLC-Q-Orbitrap MS/MS with multiple chemometric .
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PMC9479186
Student t-test was used to evaluated the difference of wound healing, MTT, Complex I activity data.
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PMC9429973
The frequencies of Rh antigens were as follows: D positive. (
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PMC11657744
The centrosome, as the microtubule-organizing center, plays a crucial role in essential cellular processes, including mitosis, cell migration, and ciliogenesis.
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PMC8916024
The Adonis (also called Permanova) test in the Vegan R package was employed for statistical comparisons of β-diversity among groups.
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PMC11658074
This results in improved skin histology, increased collagen production, a reduction in senescent cells, and decreased ROS accumulation. (
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PMC8540611
Summarized data for zeta potential and size are shown in the Table 4.
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PMC11787381
Free BBT and BBT-loaded liposomes were separated by Sepharose CL-4B column (Cytiva), and BBT in the liposome fraction was quantified by HPLC.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11471176
To detach cells, 2 ml of trypsin (12330, Biowest, Nuaillé, France) was applied and incubated at 37 °C for 3 min.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Aims: We performed a longitudinal analysis of gut microbiome composition to assess associations between gut microbial dynamics and clinical outcomes in pediatric, adolescent, and young adult patients with acute leukemia during chemotherapy and/or hematopoietic cell transplantation (HCT).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10812665
Car and Col clearly did not affect mitochondrial respiration (Figure 4A–C and Figure S7A,B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Car", "and", "Col", "c...
PMC11632064
Cell viability was measured 72 h later with the PrestoBlue HS cell viability reagent (#P50201; Thermo Fisher Scientific) following the manufacturer’s protocol.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11738017
Tumor sensitivity to anti-BCMA TCEs may be restored by the use of GSIs, reducing tumor bulk by other anti-MM agents or non-BCMA-targeting TCE or CAR T therapy, and by enhancing T-cell activity through immunomodulatory drugs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5173112
Next, to examine whether USP21 plays a role in the CSCs population in 786-O cells, we used flow cytometry approach to detect the ALDHcells, which are reported as CSCs in RCC .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9436459
Since 2015, a large number of MDAAs have been reported to have significant inhibitory activity against PTP1B (Table 6) .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "201...
PMC9429973
BH3-mimetics inhibit antiapoptotic proteins of BCL-2 family.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BH3-mimetics", "inhibit", "antiapoptotic", "proteins", "of", "BCL-2", "family", "." ] } ]
PMC6160470
Consequently, various natural ionophores (e.g. salinomycin, nigericin, valinomycin) are used as antibiotics, and more recently in cancer treatment.
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PMC11049548
To obtain the spectral buckets, each spectrum was divided into 0.02 ppm chemical shift bins from 10.00 ppm to 0.2 ppm and integrated using the AMIX 4.0.2 software.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10870498
The cells were maintained in the incubator for 24 h, and 10 µL of CCK-8 solution was added to each well to incubate with cells for 2 h. The absorbance was assessed at 450 nm using a microplate reader (Synergy HT, Bio-Tek, USA).
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PMC11541241
PLD1 has been reported to be indispensable for the class III phosphatidylinositol 3‐kinase VPS34‐mediated activation of TOR (Yoon et al., 2011).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11551844
Using percentage cell viability results for samples tested at concentrations of 0.001, 0.01, 0.1 and 1 μg mL (Fig. 5), it can be deduced that AuNPs-control was not toxic on HeLa and HepG2 cancer cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10957991
Co-staining of confluent epithelial cell cultures with TRPV4 and E-cadherin shows concentration of TRPV4 at the cell–cell junctions together with E-cadherin.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Co-stai...
PMC11587606
We thus determined the mechanism of RHBDF1-stimulated epithelial cell mobility by evaluating the expression of E-cadherin, Occludin and ZO-1 that are key proteins of TJ/AJ structures [18–20].
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11106977
Another critical inflammatory pathway in RA is the NF-kB signaling pathway .
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PMC11711871
Cells, adrenal glands, and aortas were collected in RIPA buffer supplemented with protease and phosphatase inhibitors (Roche) and quantified by a BCA assay (Thermo Fisher).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11635087
At 4 days after the co-cultivation, the layered structure of thylakoid membranes appeared to be degraded (Fig. 5H).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "4", "days",...
PMC10669966
In addition, PDE3A- and SLFN12-coexpressing LPS cell lines SA4 and GOT3 were sensitive to PDE3A modulators.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "PDE3A-", ...
PMC11225860
The combination alisertib and Aurkin A treatment showed a reduction in 8n polyploidy to 1.4% and a G1 and G2 population of 36% and 49.1% respectively, indicating that Aurkin A can revert or prevent alisertib-induced polyploidy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11764090
The transcription factor AtWRKY34 (Table 2), specifically expressed in pollen, may participate in the cascade of CBF signals in mature pollen and negatively mediate the cold sensitivity of mature A. thaliana pollen .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10243817
TGFBR3 encodes TGF-βR3, a specific TGF-β2 coreceptor and critical regulator of collagen production (28, 29).
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PMC11536589
We also observed that MGST1 knockdown decreased the cell proliferation rate (Fig. 4G).
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PMC10114490
C AAT secretion was estimated from 24-h cell media using an ELISA kit.
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PMC11391695
This hypothesis was additionally corroborated in this investigation through the observation that KCNN4 knockdown resulted in upregulation of ACYP2 expression, which inhibits K efflux.
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PMC9429973
The LPD and GP group differed significantly in relation to age (66 vs. 54 years), gender (male: 60.2% vs. 75.3%), presence of comorbidities (109, 67.7% vs. 81, 50%) patients, covid score (mild 22.5% vs. 1.9%, moderate 80, 50.3% vs. 121, 74.7%), and severe/critical 44(27.1%) vs. 38(23.4%) patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Summary/Conclusion: Comprehensive and highly optimized CNA profiling with digitalMLPA revealed subtype-defining gross-chromosomal changes and additional disease-relevant subchromosomal CNAs in a large cohort of Hungarian patients treated with ALL IC BFM protocols.
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PMC9429973
Inflammatory cytokines, including interleukin 6 (IL-6), induce expression of hepcidin, an iron homeostasis regulator, which retains tissue iron and limits circulating iron, leading to anemia.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11575040
By comparing the BRAF mutation status with LINC00094 expression levels, we found no significant difference in LINC00094 expression between BRAF wild-type and BRAF-mutated patients (Figure S4 and Table S2).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092382
and Arnebia guttata Bunge [Boraginaceae]), Bai Jiang Cao (Herba Patriniae—Patrinia scabiosaefolia Fisch.
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PMC11753435
Blots were detected by chemiluminescence using a ChemiDoc MP imager (Bio-Rad).
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PMC11026382
The gray vertical dashed lines indicate an empirical threshold for epistasis.
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PMC9429973
Results of OGM were compared with karyotyping and FISH.
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PMC9429973
IBR was discontinued in 20/61 pts (32.8%) at a median time to discontinuation of 4.1m, due to progressive disease (PD, 19.7%), toxicity (4.9%), death (3.3%; 1 pt each of Covid-19 and E. coli infection), pt choice (3.3%) and other unspecified reasons (1.6%).
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PMC11534377
Prior to hybridizatiion, the microarray probes (cRNA-Cy3) underwent purification using the RNeasy Mini Kit (Qiagen, Germany).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prior", "to"...
PMC6461034
Elute bound peptides by adding 20 μl elution solution to the StageTip and centrifuge the assembly for 2–5 min in a low‐speed centrifuge with a rotor that can hold it.
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PMC11789597
CAV1 inhibition decreased mitochondrial membrane potential and increased total and mitochondrial ROS levels (Figure 4G–I; Figure S5C,D, Supporting Information).
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