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OTAR3088
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BioData-CellLine_annotated

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PMC11746948
Relative quantification was performed using the ΔΔCT method.
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PMC11322866
EZH2 plays a critical role in normal B cell development, and its expression level influences differentiation decisions .
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PMC4443654
These cell-type-specific features present a paradox, in view of the strong correlations in organization genome-wide across different cell types , and the demonstration that models trained in one cell type often perform well with data from other cell types.
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PMC9429973
However,the risk was significantly increased due to gastrointestinal bleeding of CAR-T cell therapy for gastrointestinal (GI) lymphoma.
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PMC11736898
In normal keratinocytes, ketoconazole caused a significant decrease in CD14 expression in the absence of vitamin D, and a significant increase when combined with vitamin D treatment compared with vitamin D alone (Figure 7d).
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PMC11285179
Wild-type (pGL3 wt, 5’-TGATTATGCAATGG-3') and mutant (pGL3 mut, 5’-ACTAATACGTTACC-3') promoters of the CCL28 gene were constructed into pGL3 firefly luciferase reporter plasmid vector purchased from Nanjing Realgene Bio-Technology Company (Nanjing China).
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PMC5261804
This strong correlation is supported by multiple studies that indicate that MAPK signaling is critical for cell cycle arrest in response to DNA damage and that inhibition of p38-MAPK sensitizes lung cancer cells to DNA damaging agents .
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PMC9964654
This paper outlines our recent studies on block copolymer micelles to deliver prospective metal-based complexes with antitumoral and antimicrobial activities.
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PMC3734024
None-the-less, because of its ability to induce cytotoxic activity and increase production of both IL-10 and natural antibodies in B cells, the IL-5/IL-5 receptor axis makes for an intriguing target for therapeutic intervention in pathogenic inflammatory conditions.
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PMC11257203
The data obtained in our study are in agreement with the results of another study, which showed the genotoxic effects of indomethacin-loaded nanocapsules on the lymphocyte and HepG2 cell lines (21).
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PMC5415764
Various ratios of iRGD peptide and MAL-PEG-DSPE polymer were added to and incubated with LPNs for 1 h at room temperature in an inert N2 atmosphere.
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PMC11593084
Following three weekly injections (1 × 10 cells per rat), a final booster injection (1 × 10 cells per rat) was administered two days prior to spleen cell collection.
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PMC11502962
Moreover, it has been demonstrated that imatinib could lead to the activation of CD8 T cells and that CD8 T cells also promote imatinib’s antitumor effects (5, 15).
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PMC11144200
C The CD8 T cells were co-incubated with AnexinV-APCprestained Hep3B or A-427 cells with DC/tumor fusion vaccine at E/T ratios 1:1, 5:1, 10:1, or 20:1, with different doses of liposomal drugs for 6 h. 7-AAD was used for lysed cell staining.
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PMC10998613
The four selected clones were expanded, and QC tested with flow cytometry to measure the functional knockout of CXCR4 and ADRB2 genes (SI Appendix, Fig. S1).
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PMC9712534
White arrows indicate the area of photobleaching. (
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PMC9429973
19 were validated.
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PMC11489275
This study can remind clinicians to pay great attention to the dynamic changes of peripheral blood lymphocytes and their importance to the reflection of disease status.
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PMC11531744
However, it was still difficult to find a single effective and appropriate immune-related gene biomarker to identify and evaluate immune responses and to predict OS in OC patients.
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PMC6771295
Overexpression of SIRT1 and SIRT5 in U2OS cells showed marginal positive effects on total LC3 protein and mRNA levels implying that these sirtuin family members exert their effects on autophagy through transcriptional and non-transcriptional pathways.
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PMC11765243
Like thymus cells, mature CD4 spleen T cells from WT or p110αKD mice expressed comparable levels of p110α or p110δ subunits (Figure S4D).
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PMC11629461
C–K) Fura‐2 AM loaded SW579 cells were attached to cover‐slips and perifused.
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PMC10178190
Thus, Dasatinib’s ability to override platinum chemoresistance mediated by TA HS-5-derived CM is cell type-specific, and it is similar to the activity of JAK inhibitors.
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PMC10547921
It is believed that the design of ADCs that target the tumor microenvironment through immunomodulatory payload modification is still a hot topic in the field of future research, especially the use of payloads that are not directly toxic to cells (such as payloads that can guide the immune system to attack cancer cells).
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PMC8903741
The original gel was presented in Additional file 1: Fig. S6.
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PMC10222971
To gain further insight into the apoptosis cell death, these naphthoquinones were further evaluated on human melanoma cells (SK-MEL-28) and non-tumoral human embryonic kidney 293 (HEK-293) cells.
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PMC10529414
Specifically, the research group demonstrated that RUNX2 inhibited SIRT6 mRNA expression and interacted with the SIRT6 promoter, suppressing its activity, an effect that was associated with lower SIRT6 protein expression .
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PMC9065483
RNA was extracted from cell lysates 24 hpi and probed for MX2 mRNA expression by qPCR (n = 3, mean ± SD; ∗∗∗p < 0.001 by one-way ANOVA).
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PMC11661040
All data are expressed as mean ± standard deviation (SD).
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PMC11401358
Characterization of the secondary structure of SF by ATR-FTIR spectra. (
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PMC11777207
In a system where ligands of PD-L1 could be added exogenously, we found that neither soluble PD-1 nor CD80 could rescue migration, consistent with our hypothesis that both the intracellular and extracellular domains of CD80, but not PD-1, were necessary.
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PMC9611901
Nowadays, in vitro testing relies on the use of different cell lines.
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PMC8751435
Lactate dehydrogenase (LDH) Assay Kit (Nanjingjiancheng) was employed to assay the effect of CME on release of lactate dehydrogenase in A549 cell line as previously described.
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PMC11543853
Please note that panel a is shown at lower magnification than panels b–f. The escape of enterovirus particles or genomes from endosomes is essential for the initiation of infection.
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PMC8481254
Furthermore, we found that knocking down OGT led to a significant reduction in YAP and global O-GlcNAcylation levels, whereas overexpression of OGT upregulated the expression of YAP and global O-GlcNAcylation levels.
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PMC9429973
It is occurs in combination and is tumor-specific.
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PMC6337547
Salvia species are a rich source of polyphenols, whose application has been increasing widely used in many countries.
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PMC9429973
Results: At admission 44/47 patients had a free medical history and normal tests.
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PMC11534035
SERPINE1/PAI1 knockdown using the forward transfection technique significantly decreased cell proliferation in the resazurin assay in A431 cells (Figure 4C) relative to the siRNA control group.
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PMC11546117
LabSolutions software version 6.86 was used for system control and data processes.
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PMC6222726
Biological activities of cubebin have been recently reviewed by Cunha et al. .
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PMC10723784
Indication of combination effects relative to combination index values.
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PMC10158546
p-values were calculated using one-way ANOVAs.
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PMC9429973
The onset of TEAEs occurred primarily during year 1 (e.g., gastrointestinal and liver), with an increased incidence of some TEAEs (e.g., effusion and renal) in later years.
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PMC11266100
Afterward, 90 µL of PBS and 10 µL of cell viability reagent were added to each well, followed by 2 h incubation.
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PMC7987994
The suspension was then mixed with ZnCl2 solutions prepared as described in “Preparation of the extracts” section or by the extracts prepared as described in “Preparation of the extracts” section in 1:9 ratio (1 part of the cell suspension plus 9 parts of the extracts) and 100 µl of the mixture was seeded into 96-well plate in hexaplicates, which means the density of 1 × 10 cells per well.
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PMC11786704
Hydrogels possess good biocompatibility and can create a near-physiological environment for cells, facilitating their adhesion, proliferation, and migration [, , ].
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PMC9429973
Validation of the algorithm was performed on an independent test set composed by 7,063 cells not included in the training set.
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PMC11765243
The analysis of different developmental steps within CD4CD8 DP cells showed no differences except for a significantly higher apoptosis in the late CD3CD5 DP3 thymocytes and lower apoptosis in early immature (M1) CD3CD24 CD4 SP stages.
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PMC10212663
All analyses and visualizations were done using the R statistical language (v3.3.1).
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PMC11695623
The effects of interfering DCUN1D5 on the biological function and glycolysis level of lung adenocarcinoma cells were evaluated in vitro.
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PMC10218459
For all cytostatics, treatment with CPP for 5 s had only a minor reducing effect on cell viability.
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PMC11172027
The Jurkat-J6 cell line was centrifuged, re-suspended in complete RPMI-1640 + glutamine media (containing 10% FBS and 1% antibiotic–antimycotic solution) in flasks, and incubated at 37 °C with a continuous 5% CO2 supply.
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PMC9429973
The number of blasts was 33.20 ± 9.67 x 109 / L and was significantly lower than in the low-NLR group (p˂0.05); New count was 22.23 ± 0.10 x 109 / L; Lym count - 22.83 ± 3.04 109 / L. The NLR was 1.24 ± 0.16.
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PMC10812665
To characterize the mode of action (MoA) of the hits from an environmental toxicants screen, we designed a multi-omics approach.
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PMC11257988
However, Cai et al. revealed that KRASG12D mutation was associated with the shortest progression-free survival (PFS) and overall survival (OS) when compared with KRASG12C and KRASG12V, and the KRAS G > T group had better PFS and OS than the KRAS G > C and KRAS G > A groups at the amino acid substitution level .
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PMC11025866
The overall goal was to characterize global gene expression patterns in cells responding to VPM, a non-HDAC inhibitor, compared to two HDAC inhibitors, VPA and NaB. However, NaB leads to induction of BZLF1 that promotes expression of downstream EBV lytic genes and causes major changes in gene expression patterns and alters metabolism in the cell .
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PMC11585994
Hematoxylin-eosin staining (HE) and immunohistochemistry (IHC) staining, along with scanning, were conducted by Wuhan Borfu Biotechnology Co., Ltd. For confocal imaging, siBCL11B-Cy5 and sgc8-FAM were used to label the nanoparticles.
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PMC11481779
Using hidden representation is necessary to guide the diffusion, thus creating a conditional diffusion model.
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PMC10253973
A number of studies included subsequent molecular docking DFT calculations to further investigate the interactions of ruthenium complex–drug target systems and to obtain reliable estimates of binding energies and binding sites.
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PMC11049294
The aim was the development of a flow cytometry assay to measure AGAL activity in individual cells.
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PMC9429973
ITD allelic ratio (AR) was known for 28 (80%) pts (AR range: 0.01-0.95) with 11 (31%) pts having an AR ≥0.5.
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PMC11343332
A p< 0.05 cutoff was used to determine statistical significance.
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PMC5811757
Real-time PCR data revealed that ABCB1 gene expression level was dramatically down-regulated as the result of indel mutation.
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PMC5363531
These results could be dependent by clone conditions, suggesting that in those clones with low basal TS promoter activation, the inhibition of TS protein by pemetrexed activates a feedback on promoter increasing the expression of luciferase, while in clones with massive basal activation, the system reaches a plateau level and 1 μM pemetrexed cannot increase the expression of luciferase.
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PMC11700165
Anti-SLP-76 pY128 was from BD Biosciences Pharmingen.
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PMC10919056
The wound healing process was monitored at different time points, and images of the scratches were captured using an inverted microscope after 12 hours.
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PMC5261804
For, example in the network given by Fig 1 the essentiality for node 1 and 2 of the dual graph (edges e1 and e2 in the original network) are updated as follows: e1(t+1)=(1−α) e1(t)+α(p1 e2(t)+p2 e3(t)p1+p2) e2(t+1)=(1−α) e2(t)+α(p1 e1(t)+p3 e3(t)+p3 e4(t)p1+p2+p3) The weight of each edge is influenced by the essentiality of the protein.
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PMC10874773
C12-C14 esterification.
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PMC10443665
Taxonomic identification of the specimen was done by the Research Center for Agriculture and Natural Resources of Isfahan.
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PMC8633974
Three HIV-1NL4-3-Δnef-eGFP non-frameshift point mutants were created to parallel CRISPR mutation profiles (Figure 4a), in which two- (ΔTatD), three- (ΔTatE), or five (ΔTatDE) exons were altered (Figure 4b).
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PMC9429973
AML patients that are ineligible for intensive chemotherapy are typically administered injectable azacitidine (AZA) at a dose of 75 mg/m for 7 days in combination with BCL-2 inhibitor venetoclax (VEN) as induction therapy.
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PMC11673128
A minimum of 200 macrophages was counted per condition to ensure reliable quantification.
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PMC11697065
DESeq2 (version 1.42.1) was used with R (version 4.3.3) on a Debian GNU/Linux 12 (bookworm) operating system, hosted inside a Singularity container.
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PMC11676674
In addition, myricetin possesses a strong antioxidant property and specific pharmacological activities such as hepatoprotective, antitumor, anti-inflammatory, analgesic, and antidiabetic effects .
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PMC9429973
Recently, we have shown that a subset of small non-coding RNAs, i.e. C/D box snoRNAs are overexpressed in acute myeloid leukemia (AML) and required for AML1/ETO-driven leukemia initiation and maintenance.
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PMC11291490
Furthermore, dusCD40L could strengthen virus clearance of the prM-E DNA vaccine in ducks post-TMUV challenge.
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PMC3734024
B cells cultured with IL-4 and CD40L Fb did not display any detectable killing activity, in contrast to the measurable antigen-specific apoptosis induced by CD40L stimulation alone and the robust killing displayed by B cells stimulated with IL-5 and CD40L Fb. (
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PMC11023271
Similar outcomes were observed when MTT analyses were performed, in which the differences between shControl and shRIPK4 cells were decreased upon LPA treatment, in comparison with vehicle control (S5 Fig).
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PMC10523483
ChIP and re-ChIP assay were performed as described (50).
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PMC10933092
Cellular proteins were solubilized in radioimmunoprecipitation assay (RIPA) lysis buffer containing a protease inhibitor cocktail (MedChem Express, United States).
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PMC5600151
In the divergent growth method, the final molecule grows radially from a core by the sequential addition of layers of monomers, each layer constituting a new generation.
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PMC11721295
Standard curves were generated using non-conditioned media and analytes were quantified on the Luminex 200 instrument.
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PMC9429973
E. M. Mahtat, I. Ait Filali, M. Allaoui, S. Jennane, H. El Maaroufi, M. Oukabli, K. Doghmi Clinical Hematology; Pathology, Hôpital Militaire Mohamed V Rabat, Rabat, Morocco Background: Diffuse large B cell lymphoma is classified into two molecular prognostic subgroups: germinal center B cell like (GCB) and activated B cell like (ABC), based on cell of origin (COO).
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PMC8140214
BSA total protein assay kit was purchased from Bio-Rad (Hercules, California, USA).
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PMC5673955
Cells were labeled with Annexin V‐FITC and propidium iodide.
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PMC9429973
Aims: In this study we aimed to analyze the proteome of ET platelets and to characterize their functional properties according to the mutational background and treatment regimens.
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PMC9684669
Consistent with the CAMK2 inhibitors, ABCB1 and BIRC5, along with CREB1 phosphorylation, decreased after treatment with 666-15 ( Figure 6G and Figure S7B ).
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PMC11802855
Subsequently, the association between the expression level of CXCL7 and pathological fractures in patients was investigated, and the impact of CXCL7 on MM proliferation was confirmed both in vivo and in vitro.
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PMC6600253
Several studies have indicated that, because HIV reverse transcriptase and telomerase are similar, AZT preferentially binds to the telomeric region of DNA in CHO cells .
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PMC11621493
This article contains supplemental data.
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PMC8913139
In previous studies, Rho-associated protein kinase 1 (ROCK1) has been reported to play a role in malignancies.
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PMC11451940
Then, the residue was suspended in pentane for 2 hours and reprecipitated with a CH2Cl2/petroleum ether (ca.
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PMC9429973
Image: Summary/Conclusion: The life expectancy of CLL patients diagnosed in the Netherlands between 1989-2018 has steadily increased over time.
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PMC11766309
YKT6 expression was positively correlated with MSI in CESC (P=0.002), GBM (P=0.022), KIRC (P=0.015), LIHC (P=0.012), LUAD (P=0.043), LUSC (P=0.008), SARC (P=0.001), and TGCT (P=0.036).
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PMC11352746
This paper reviews the current state of live-cell imaging instruments, with a focus on the most commonly used equipment (IncuCyte systems).
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PMC10578720
Ten weeks after DCA treatment, the liver, spleen, and peripheral blood were harvested from each mouse for subsequent analysis (Figure 6B).
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PMC9429973
Statistical analyses were performed using SPSS Version 25 (IBM Corporation, Armonk, NY, USA).
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PMC7039683
We amplified five ~ 400 bp elements, located approximately +6 kb, +3 kb, −8 kb, −11 kb, and 0 kb from the transcription start site of cldne and engineered them into a reporter vector upstream of a minimal promoter and cDNA encoding GFP (Fisher et al., 2006b; Figure 1C).
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PMC11795610
CCK8 assay showed cell proliferation was significantly inhibited by agonist GSK1016790A, and further inhibition was observed by the combination treatment of GSK1016790A and myricetin.
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