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PMC11703992
A 21 cell clusters were obtained after PCA analysis, and 7 types of cells were identified by manual annotation.
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PMC11394730
In contrast, epithelial markers like E-cadherin and claudin were elevated .
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PMC9429973
Cytogenetic and molecular exploration were conducted using bone marrow and blood samples.
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PMC9424261
H Total ubiquitination of GSS, as co-IP by anti-GSS antibody for the indicated treatment in Bel-7402 cells with or without HERPUD1 knocked out, and measured by anti-total ubiquitin antibody.
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PMC11767725
AD is a chronic inflammatory skin condition defined by intense itching, eczematous lesions, and impaired epidermal barrier function.
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PMC10547921
Most auristatin analogs studies have been focusing on C-terminal or N-terminal modifications.
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PMC11271278
ETV1 was reported as an androgen-responsive gene in LNCaP cells promoting cell invasion.
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PMC11684297
The secondary structure of amyloids contains β-sheet rich regions, and the fluorescence enhancement mechanism after amyloid binding is due to the rotational immobilization of benzothiazole and aniline rings connector central C–C bond .
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PMC9429973
Summary/Conclusion: These experiments will identify targets of the RAS pathway essential for the survival of AML cells.
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PMC11674834
Reaction tubes were centrifuged at 15,000× g for 10 min to precipitate protein.
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PMC10529414
Therefore, new diagnostic biomarkers and therapeutic targets are urgently needed.
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PMC7053076
Fig. 3The cytotoxic effect of U-332 (a) and BGD (b) on HL-60 and HL-60/5FU cells analyzed by MTT assay The cytotoxic effect of U-332 (a) and BGD (b) on HL-60 and HL-60/5FU cells analyzed by MTT assay Analysis of the expression level of c-Rel, RelA, RelB, NF-κB1 (p100/p50) and NF-κB2 (p100/p52) genes in the HL-60 and resistant HL-60/5FU cells was performed by real-time PCR.
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PMC11730311
A γGlu linker was incorporated between the peptide and the connected C18DA or C20DA.
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PMC7762347
Consequently, this can lead to cancer development especially after long-term exposure to low concentrations of MCLR .
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PMC6461034
Second, kinase activation loop phosphorylation is analyzed.
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PMC11295144
p < 0.05).
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PMC9105697
However, approximately one third to fifty percent of all patients experience a local recurrence or metastases after the primary resection .
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PMC10452486
The dissociation of B2m results in the unfolding of α1 and α 2 domains of HCs; these are referred to as “non-conformed” B2m-free HCs.
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PMC10728535
A comparison was made between OC groups resistant to cisplatin and those sensitive to it, and differentially expressed genes were identified with no regard to French‐American‐British (FAB) classification, drug dose, and sample source.
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PMC9429973
Further, patients with and without extramedullary disease both had a benefit with blinatumomab.
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PMC9429973
Two-year OS in these combined group was 74%, that remained to significantly exceed OS in “high-risk” MA patients (p=0.03, Log-rank test).
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PMC7917457
SIINFEKL epitope-specific T cells were studied using an APC-labeled H-2Kb/SIINFEKL pentamer (F093-84B-E; ProImmune).
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PMC11767793
As AuNPs absorb at 490 nm (the readout of MTS assay), this may elevate the final absorbance readout and misrepresent the assay result.
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PMC9429973
A diagnosis of t-AML or AML-MRC between 01/01/2013 and 31/03/2021 was determined either directly using International Classification of Diseases for Oncology, Third Edition (ICD-O-3) codes or indirectly using nonspecific ICD-O-2, ICD-O-3, or ICD-10 AML codes in combination with prior systemic anticancer therapy or radiotherapy (t-AML) or a prior diagnosis of MDS/CMML (AML-MRC).
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PMC11635087
Subsequently, the algae are surrounded by a membrane derived from the DV membrane (i.e., perialgal vacuole membrane) in the acid phosphatase-inactive region within the lysosome.
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PMC5854676
Snapshot during microinjection. (
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PMC3035438
To make the targeting vector, we first cloned a human genomic region including the last three exons (hinge H, CH2, CH3) of the Ig gamma-1 heavy-chain constant region (human IgHG1).
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PMC5925824
T cell activation occurs when T-cells receive two positive signals from antigen-presenting cells (APC): an antigen-specific signal presented in the context of major histocompatibility complex (MHC) which engages the T-cell receptor (TCR), and a co-stimulatory signal from B7–1/B7–2 (CD80/CD86) to the CD28 receptor on T-cells .
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PMC11116779
Heme oxygenase-1 (HO-1) (encoded by the HMOX1 gene) is another key antioxidant enzyme reported to be highly expressed in the lungs (37).
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PMC9429973
The average age of the patients was 30.4 years (from 23 to 75 years old).
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PMC8740518
The GC-TOF-MS settings were as follows: 1 µL sample was loaded in a splitless mode, 3 mL/min for the front inlet purge flow rate, 1 mL/min for the gas flow rate; the initial temperature was 50 °C, then increased to 310 °C with a rate of 20 °C/min, then kept at 310 °C for 6 min; the temperatures for injection, transfer line, and ion source were 280, 280, and 250 °C, respectively; the electron impact energy was set at 70 eV; full-scan mode with a mass-to-charge ratio range from 50 to 500 was used in mass collection.
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PMC9587866
The Ewing sarcoma (EWS) is an aggressive and metastasis prone bone tumor which commonly affects the younger adolescents and children.
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PMC11532793
We find that only a couple of hundred technical replicates are required in total, across all samples in the study, dramatically reducing the number of resamples that are recommended per library for large studies.
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PMC11786600
These results imply that kaempferol may suppress the NF-κB signaling pathway, leading to MMP9 downregulation, thereby mitigating inflammation and promoting avoidance of the apoptosis pathway.28,40 Additionally, the study indicates that the combination of kaempferol and electrospinning material displays remarkable compatibility, with the electrospinning dressing serving as an effective vehicle for the wound-healing properties of kaempferol.
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PMC11621493
Additionally, the fold change (KO/WT) and FDR-adjusted P value are shown.
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PMC11484188
Finally, miR-1343-3p regulated ATG7 and autophagy in MM cells using western blot analysis.
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PMC9895440
tSNE plots with selected transcripts highlighted as dot size and color were generated using ggplot2.
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PMC10854447
To investigate the effect of compounds 7a–o on normal cell lines, a cell viability experiment was performed on the MCF-10A (human mammary gland epithelial) cell line.
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PMC11607764
Looking forward to the next 5 years, with the continuous progress of research technology and in-depth understanding of the mechanism of action of PTBP1, significant breakthroughs in the field of PTBP1 research are bound to be achieved.
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PMC11773391
Cultured malignant melanoma cell lines A375 and Sk‐MEL28 were employed.
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PMC9118379
We noted that 249 (77.8%) out of 320 variant PSMs were filtered out by the 11 postexaminations.
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PMC4443654
In each instance of cross-application, predictive accuracy declined by no more than 21% relative to the model’s native cell type.
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PMC9429973
Addition of the CD3xCD20 plamotamab to the TAFA+LEN doublet offers the potential for improved efficacy through recruitment of distinct T cell and Fc-mediated cytotoxic mechanisms while also overcoming tumor resistance that might otherwise arise from single antigenic loss of either CD19 or CD20.
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PMC8875242
The final concentrations of EtOH in hPCIS and Caco-2 cells were 0.03% and 0.012%, respectively.
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PMC7090062
IM is now the standard first-line drug for patients with unresectable primary GISTs or metastasized recurrent GISTs.
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PMC8336407
The total flavonoid and phenolic contents, the cell viability, lipid peroxidation, NO generation, and the total antioxidant capacity in cell media were assessed.
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PMC11763533
Cells transfected with pCMV-Mac exhibited reddish bioluminescence at all pHs.
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PMC11782780
Therefore, we believed that hsa-miR-301b-3p was an upstream regulatory gene of EBF3.
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PMC11795610
Keratin 5 mRNA. (
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PMC11519567
We wish to test how these two different condensates interact with each other (Fig. 4A).
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PMC10758402
The tumors were dissociated utilizing the Miltenyi mouse tumor dissociation kit (Miltenyi Biotec, CA, USA, Cat. #
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PMC9960565
Cisplatin UV-Vis spectrum presented a maximum absorbance band at 203 nm attributed to a charge-transfer band and a shoulder at 280 nm assigned to the d-d transitions of the square planar Pt ion (Figure S27a).
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PMC7685376
Relative mRNA levels of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7 in SK-Hep1 and Bel-7404 cell lines treated with Huaier (15 mg/mL) for 24h (Student’s t-test, n = 3).
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PMC9429973
At the current follow-up periods, there were no significant differences in PFS and OS regarding a follow-up period <= 24 months (with the exception of death from COVID-19, since patients were not observed at parallel time intervals).
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PMC11544771
We also noticed that treatment with CPX alone dose-dependently increased the levels of p21 (Cip1) and p27 (Kip1), two CDK inhibitors, in both A549 and A427 cells, which was strengthened by addition of PRE (Figure 4C,D and Figure S2C,D).
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PMC11240448
As such data are increasingly being produced on cancer patients, we envision that our approach will facilitate the generation of digital twin models of individual cancer patients.
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PMC10936243
Similarly, in other countries, the financial status of the client has been recognised as a common barrier to providing good cat care in veterinary practices.
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PMC10547921
The PBD dimer payload 66 will contribute to the design of new ADCs with higher therapeutic potential.
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PMC11591030
Quantitative and qualitative assessment of the RNA was carried out using an ultraviolet spectrophotometer (BioTek, Winooski, VT, USA) at 260 nm and 280 nm.
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PMC9545714
It was also noteworthy that two galactosyltransferase genes were affected by GTE.
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PMC11718809
We combined our miRNA data (unpublished) to construct the circRNA–miRNA–mRNA regulatory network.
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PMC5925824
These analyses clearly demonstrated the ability of LY3300054 to modulate human T cell functions as reflected by increased peripheral T cell numbers and in particular CD8 T cells, and enhanced activation status of peripheral allo- and/or xeno-reactive T cells triggered through TCR engagement.
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PMC8097906
10 nM) treatment compared to the vehicle control (0.1% DMSO).
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PMC10317042
Transformation was performed using Competent Quick DH5a (DNA-913F; Toyobo), and plasmids were purified using NucleoBond Xtra Maxi (Macherey-Nagel) according to the manufacturer's instructions.
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PMC9429973
Q.-N. Shang, X.-X. Yu, Z.-L. Xu, T.-T. Han, J. Xie, Z.-Y. Fan, M. Zhao, X.-H. Cao, X.-F. Liu, Y.-H. Chen, M. Lv, Y.-Q. Sun, Y.-J. Chang, Y. Wang, L.-P. Xu, X.-H. Zhang, K.-Y. Liu, X.-Y. Zhao, X.-J. Huang Peking University People’s Hospital; Peking University Institute of Hematology; Peking-Tsinghua Center for Life Sciences, Beijing, China Background: Cytomegalovirus (CMV) infection remains a common complication and leads to high mortality in subjects who undergo allogeneic hematopoietic stem cell transplantation (allo-HSCT).
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PMC9429973
Aims: Explore whether patients with chronic myeloid leukemia (CML) presenting in accelerated-phase could benefit from initial second-generation tyrosine kinase inhibitor (2G-TKI) therapy.
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PMC11777207
We previously published and showed (Fig. 3) that when PD-L1 cytoplasmic residues T277, S278, and S279 were converted to alanine, DC migration was significantly impaired both in vitro and in vivo when activated with LPS or polyI:C (26).
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PMC11597291
At 5 h, the nCGO-PEG/PCT and the free PCT exhibited comparable cytotoxicity values against the A549 cell line, while at 24 h and 48 h, the nCGO-PEG(10 kDa)/PCT significantly surpassed the anticancer activity of free PCT (Figure 5A,B).
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PMC9429973
Aims: To identify significant mutations in the genes in patients with PMBCL for the further studies.
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PMC11277157
Each experimental group is represented by three biological triplicates.
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PMC11632064
Compared with parental cells, Rho-0 cells were characterized by a dramatic reduction in the mtDNA/genomic DNA ratio, reduced expression of labile respiratory proteins subunits, and absence of mitochondrial respiration (Figs 6K and S4B and D).
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PMC11731614
Our study suggests a novel strategy for treating PDN by focusing on the skin rather than the entire body.
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PMC7504302
Molecular studies in MPM have identified aberrant epigenetic events affecting the pathogenesis of the disease.
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PMC9429973
Methods: A total of 4 patients developed ischemic stroke after allogeneic HSCT in a single center in 2019, 75% male and 25% female, aged between 43 and 70 years.
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PMC11489351
To ensure that the reduction in Notch1 expression at low pHi was the result of lowered pHi and not macropinocytosis inhibition, we treated MCF10A cells with a specific macropinocytosis inhibitor (imipramine) for 24 h (see Methods) and found that imipramine treatment did not affect Notch1 abundance (Fig. 3, A and B).
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PMC11774112
The specified time periods were 1, 2, 4, 6, 8, 10, 12, 24, 48, and 72 h. The amount of residual DTIC in the nanomicelles was determined by HPLC using the same procedure as described above.
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PMC10094712
SELENOM can be considered a marker of brain selenium deficiency, as it is sensitive to changes in the concentration of this trace element in the brain.
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PMC9429973
JAK2 gene encodes for a non-receptor tyrosine kinase fundamental for hematopoiesis and itsmutations have been widely studied, whereas JAK2 fusion genes are still poorly characterized.
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PMC6835428
A final factor, which should be considered to improve the effectiveness of delivered siRNAs, deals with biological aspects, i.e., the targeting of OC stem cells (OCSCs).
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PMC6181431
One hundred twenty-nine genes showed a significant increase in the cancer cell fraction for a single mutation in a single post-treatment tumor sample in comparison to the pre-treatment sample (S4 Table).
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PMC7351993
d Scatter plot of Chlamydomonas sp. mutant cells in cell area and lipid density.
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PMC10212663
BCAM has been shown to play a functional role in the metastasis of multiple malignancies.
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PMC11519567
Consistently, we show that SS18-SSX condensates are more temperature resistant than SS18 as it takes up to 42 °C to dissolve SS18-SSX condensates in 30 min, compared to 40 °C in 2 min for SS18 (Fig. S1A, B).
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PMC9429973
D. Belloumi, I. Ben Yaiche, J. Fekih, A. Ghorbel, L. Torjemane, M. Chaabane, S. Mekni, N. Ben Abdeljelil, I. Turki, S. Ladeb, S. Hmida, T. Ben Othman Centre national de greffe de moelle osseuse, Tunis, Tunisia; Unité de thérapie cellulaire, Centre national de transfusion sanguine, tunis, Tunisia Background: Cryopreservation of hematopoietic stem cells (HSC) is associated with variable loss of CD34+ graft richness.
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PMC9429973
At 3 months, 98.0%, 87.9%, and 75.4% of pts achieved MMR, MR4 and MR4.5.
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PMC9429973
The pan-PI3Ki were overall most potent in inhibiting CLL cell viability.
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PMC9509578
Joshi et al. demonstrated the reversal of hypoxia-mediated drug resistance in resistant A2780/ADR and MCF-7/ADR cell lines as well as in 3D spheroid cultures via co-delivery of doxorubicin and anti-P-gp siRNA (siP-gp)-conjugated PEGylated nanoparticles.
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PMC5308810
We further investigated whether drug treatments enrich tumoral CXCR4-C. We treated SCID mice implanted with SK-OV3 (transfected with GFP and luciferase) with doxorubicin.
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PMC9429973
The edited cells were analyzed in ex vivo functional assays (e.g. IF staining and WB) and their transplantation efficiency was determined in NSG mice.
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PMC10778532
Similar results were obtained in a model of colorectal cancer where sunitinib induces EMT with downregulation of E-cadherin and upregulation of Slug and Zeb1 in favor of tumoral progression .
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PMC11576293
Compounds 22 and 29, the most potent derivatives, were further investigated against the Bax/Bcl2 ratio using Staurosporine as the reference drug (Youssif et al., 2019).
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PMC11541241
The TOR pathway is present in U. maydis.
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PMC10502403
Each bar represents the mean relative areas of the indicated metabolites.
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PMC9841531
In short, cells that were stained with PI only were considered necrotic cells (Q1), while cells stained with both PI and Annexin V were late apoptotic (Q2), and cells stained with Annexin V only were early apoptotic (Q4).
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PMC11144200
This combination therapy is anticipated to have synergistic antitumor effects.
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PMC11597291
The significantly improved biocompatibility characteristics of the nCGO-PEG nanocarriers were evidenced by the reduced hemolytic potential and decreased cytotoxicity of the pegylated particles compared to CGO controls.
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PMC11348300
Displays the mouse leg after complete resection, free of PRESTO signal. (
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PMC11697189
Univariate and multivariate analysis suggested that the signature was an independent risk factor affecting the prognosis of ccRCC.
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PMC7090062
Among the 15 miRNAs tested, miR-30a-5p displayed the largest decrease in expression in GIST-882 cells following IM treatment.
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PMC11544122
All curves were fit by nonlinear regression (log(agonist) vs. response (three-parameters)) using GraphPad Prism.
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