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BioData-CellLine_annotated

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PMC11321678
We, therefore, performed subtype‐specific NTR gene knockdown in Group 3, and Group 3/4 cell lines (Figure 6D,E).
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PMC9926039
In this study, the effects of methadone and naloxone on the expression of toll-like receptor 4 (TLR4) gene have been evaluated in human non-small cell lung carcinoma A549 cell line migration using in-silico and in vitro techniques.
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PMC11686380
Analyses were done as in (A).
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PMC11795610
The calcium (Ca) in the epidermis, increasing from the basal layer to the granular layer, plays an important regulatory role in the KC differentiation.
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PMC9856122
BBR is able to suppress IL-6, IL-1β, IL-1α, and TNF-α by inhibiting Nod-like receptor protein 3 (NLRP-3) pathway .
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PMC11787355
PTPRZ1-specific TCR-T (PTPRZ1-TCR-T) kill target cells antigen-specifically, and in murine experimental brain tumors, their combined intravenous and intracerebroventricular administration is efficacious.
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PMC11519583
Fig. 6Co-stimulation with Wnt5b and Wnt11 induces IMAT accumulation in Ctx-injected skeletal muscles.a Proliferation of MPs, treated with respective siRNAs in the absence or presence of Wnt5b (200 ng/ml), was evaluated using WST-8 assay at the indicated time points (n = 3).
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PMC9429973
No intra-patient dose escalation from 24 mg/kg to 30 mg/kg is permitted.
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PMC11012313
Due to the emerging role and importance of HIF-1α in promoting chemotherapeutic resistance , our data suggest that the LMP2A-mediated increase in HIF-1α may contribute to EBV-mediated evasion of chemotherapy.
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PMC11144200
We first successfully finished the preparation of DC/tumor fusion Cells.
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PMC8557138
However, the authors also observed that the vascular spouts regressed after 8 days of culture (Aplin and Nicosia 2016).
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PMC8592717
PCA is a water-soluble benzoic acid derivative (Figure 1), reported to have anti-atherosclerotic, anti-inflammatory, antineoplastic, analgesic, antibacterial, hepatoprotective, and antiviral effects in both in vivo and in vitro studies [3-6].
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PMC9672323
Our findings suggested a protective effect of piroxicam, but not dexamethasone, on PBMCs against inhibitory mechanisms of two glioblastoma cell lines, U-87 and A-172 cells.
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PMC11585254
To compare wild-type and variant receptors, the AUC at each CXCL13 concentration was normalized to 10 μM CXCL13 of the wild-type CXCR5.
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PMC10237474
The starting concentrations of puromycin and hygromycin were 0, 1, 2, 4, 8, 16 mg/L and 0, 10, 20, 40, 80, 160 mg/L, respectively.
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PMC11802929
Further, clonotypes that exhibit memory and progenitor-like phenotypes at acute disease persist or expand at convalescence.
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PMC4395774
Thus, both vectors were able to restore cytotoxic activity in primary murine perforin-deficient peripheral T and NK cells.
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PMC8592717
Oral pretreatment with PCA might counteract insulin resistance status partly through induction of AKT phosphorylation and mitigation of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) expression in dexamethasone (Dex)-induced hyperinsulinemia and insulin resistance in rats .
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PMC11739504
Western blots also showed decreased Kat2b expression in KO mice. (
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PMC8557138
Moreover, bioprinting offers the possibility of controlling the alignment of cells, as well as to strategically modulate cellular signaling pathways; thus recapitulating the specific microstructure of target tissue or organ compared to standard tissue fabrication approaches (Chakraborty and Ghosh 2020).Bio-inks are the key elements of any bioprinting process, in which the cells are encapsulated and extruded to develop the tissue or organ of interest.
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PMC11707577
E,F) Transcriptional analysis of stress and apoptotic responsive genes in response to photodynamic treatment.
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PMC11773391
In a previous report by Sato et al., MEK inhibitors reversed the resistance of glioblastoma cells to TMZ, and MEK inhibitors combined with TMZ effectively controlled the occurrence and development of glioblastoma cells.
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PMC11467964
We generated mutation annotation format considering the recognized important role of somatic mutations in tumor cell migration and proliferation through “maftools” package.
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PMC11400680
As observed in the boxplots of Figure 7A, the minimum of Mean IoU values for cell segmentation in all three sets exceeds 0.6, indicating that our proposed method effectively segments cells, with the majority masks achieving an IoU >0.6.
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PMC9429973
Previously, we showed that limiting iron availability with the oral ferroportin inhibitor vamifeport (also known as VIT-2763) ameliorated anemia, ineffective erythropoiesis, and the dysregulated iron homeostasis in the Hbb murine model of β-thalassemia under non-transfused conditions.
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PMC11023271
The MTT cell proliferation analyses were performed using the MTT Cell Growth Assay Kit, following the manufacturer’s instructions with some modification.
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PMC11499381
Goat serum (10% in PBS; Cat# 16210064, Life Technologies) was used as a blocking agent; cells were blocked for 1 h at room temperature with shaking.
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PMC9429973
Cumulative incidence of relapse (CIR) at 5 years among the 752 patients who achieved complete remission was 41% (95%CI 37-45).
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PMC11707577
Gene expression analysis through real time quantitative Reverse Transcription Polymerase Chain Reaction (qRT‐PCR) was performed to identify the molecular pathways (oxidative stress and apoptosis) possibly modulated by M13EGFR(TNP)‐mediated photodynamic treatment.
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PMC11806182
Survival analysis assessed the prognostic value of these miRNAs in UCEC.
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PMC9429973
First-line treatment pathways and their related efficacy will be evaluated in newly diagnosed CD30-expressing lymphoma patients in China.
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PMC9599726
Erastin, liproxstatin-1, deferoxamine mesylate, RSL3, CA3, and staurosporine were purchased from Selleckchem, Houston, TX, USA (Cat# S7242, S7699, S5742, S8155, S8661, and S1421, respectively).
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PMC11785489
Nonproductive TCR sequence transcripts can be detected when an out-of-frame V(D)J recombination event on one chromosome is followed by an in-frame V(D)J recombination event on the other.
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PMC9143157
However, this hurdle could be overcome by increasing the dosing of drugs, which the high tumor accumulation, and thus low toxicity, of P-THP will enable in dose escalation, which needs further investigations.
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PMC11543885
Prepare and equilibrate the column by flushing first with 5 mL of solution B (65% CH3CN, 35% MilliQ-H2O, 0.1% TFA) and 10 mL of solution A (98% MilliQ-H2O, 2% CH3CN, 0.1% TFA).
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PMC11394730
Furthermore, when the Luteolin (aglycone form) and LUT-7-O-glucoside forms were evaluated for their respective actions, the aglycone form showed more potent antioxidant, antidiabetic, and anti-inflammatory properties .
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PMC11721295
Cells were centrifuged at 433g for 7 minutes at 4°C and the pellet was incubated with 1 mL red blood cell lysis buffer.
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PMC11562028
The Re-CDs solution was obtained after centrifugation with a 3500 MW ultrafiltration tube at 5000 rpm three times under 4 °C for 5 min.
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PMC6803987
The HL-7702 cell line is a normal liver cell line.
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PMC11224020
Libraries were then pooled at equimolar concentrations and quantified by qPCR using a KAPA library quantification kit (Roche).
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PMC9429973
Furthermore, absence of STAT3β favored leukemic infiltration and migration.
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PMC8143558
The WHO has reported that access to soap and water in 2019 was limited to only 57% of the world’s school children, with 818 million, that is 43%, having no access to soap and water .
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PMC11464982
The gel showed a major protein band corresponding to an apparent molecular mass of around ■■■■■ kDa, consistent with the expected molecular mass of the enzyme.
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PMC7342409
Compared with the resistant group, there was a significant increase in the body weight of the mice in the imatinib group and the CQ group day 0 and day 3 of the drug administration (p<0.01).
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PMC11422497
The activated KIT gene further activates downstream signaling pathways, particularly the JAK/STAT pathway, ultimately driving the malignant progression of GISTs.
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PMC8740518
Therefore, the aim of this study was to discover promising metabolite biomarkers to improve early MM diagnosis.
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PMC10798140
Yield: 30%.
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PMC9429973
Only patients who developed grade 2 or higher reactions (CTCAE 3.0) were included in this study.
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PMC9919300
The microarray analysis of the genes involved in human fatty liver were performed in triplicates using HepG2 cells grown in EMEM (control, red) and HepG2 treated as reported in Section 4: curcumin (group 2, green), andrographolide (group 3, yellow), and their association (group 4, blue).
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PMC9429973
Questions covered topics such as disease impact on QoL, symptoms, disease complications, treatment goals, treatment strategies, and COVID-19.
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PMC10728535
Here, the considered chemotherapy regimen consisted of only cisplatin.
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PMC8662250
The ongoing pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has led to unprecedented challenges for the healthcare systems worldwide (Chung et al., 2021).
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PMC11412752
In this study, a STING knockout HepG2 cell line was constructed through the application of CRISPR/Cas9 technology.
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PMC7433824
All the cell culture experiments were designed as triplicates.
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PMC2193049
Cells expressing a short-lived variant of the MAGE-31–314 protein were not recognized by specific CTL, either (data not shown), eliminating the possibility that the lack of recognition was caused by a slow degradation of the MAGE-3 protein leading to a suboptimal concentration of the antigenic peptide.
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PMC11474209
They have various structural characteristics and modes of action .
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PMC11545737
Infections of Caco-2 cells and normal human colonic epithelial NCM460 cells revealed that SopF inhibits GSDMD-mediated and, especially, the GSDME-mediated pyroptosis through the caspase-3/GSDME pathway, by inactivating the caspase-8.
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PMC11487720
B Similarly, WWOXd cells, including MDA-MB-231, NB69, Wwox knock out MEF, 4T1, NIH-3T3, and L929R cells, were exposed to UV (960 mJ/cm), followed by time-lapse microscopy at room temperature (200x; scale bar 50 µm).
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PMC11700247
E-F) Expression of ifna1, inb1, cxcl9, and cxcl11 48 hours post in vivo RT. (
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PMC11224020
N = 3).
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PMC11502066
Over the past few decades, an increasing number of studies have demonstrated the anticancer role of plant-derived low-molecular weight polyphenolic compounds, flavonoids, in diverse types of malignancies.
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PMC9895440
The next day, 10 nM NY-ESO-1 9 V peptide and 10 U/ml recombinant human IL-2 in 100 μl human serum RPMI medium (see above) was added to these wells.
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PMC7802142
Measurements were carried out in three fields per mouse and the average value was expressed in micrometers.
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PMC9429973
Proceedings of the National Academy of Sciences 116(7): 2545-2550.
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PMC11754784
Then cells were washed with DPBS three times and incubated with Nb or Nb-S at 4 °C for 30 min.
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PMC10547921
Figure 5Design and SAR analysis of eribulin analogs. (
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PMC9429973
We observed higher frequencies of del(17p) and gain 1q in del(1p32) patients (21.3% and 53.2% respectively), compared to general MM population.
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PMC11334037
Upon ligand binding, the activated tyrosine kinase domain initiates signaling cascades that specifically activate the GPTase Ras-Raf-ERK/MAPK and PI3K-AKT/mTOR pathways.
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PMC4369959
Besides these, ginger has been reported as a pain relief for arthritis, muscle soreness, chest pain, low back pain, stomach pain, and menstrual pain.
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PMC3995603
Artemisia capillaries Thunb. (
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PMC11711127
Senescent T cells have been implicated in chronic viral infections, autoimmune disorders and cancer (76).
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PMC11297139
For spheroid invasion assay, next day, matrigel (BD Biosciences, Bedford, MA) was added directly to the media containing the spheroid.
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PMC9727330
The complete RPMI medium was added to the trypsinized cells, which were then centrifuged for 3 min at 1500 rpm.
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PMC11321678
Human MB tissues were approved by the Reproductive Study Ethics Committee in Huashan Hospital affiliated with Fudan University, China.
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PMC11638255
c Flow cytometric analysis of myeloid subset frequencies from tumors after 1 week of treatment.
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PMC11461874
The half-life of protein was calculated using exponential regression and shown on the right as mean ± SEM.
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PMC6337547
This is a shortcoming in the study of chemical constituents and pharmacological effects of Chinese Salvia species.
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PMC11285179
Six-week-old female BALB/c nude mice and C57BL/6 female mice were used for tumor model establishment.
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PMC9429973
Prior to the auto-HSCT 42 patients had reached the CR, 48 - VGPR, 15 - PR, 4 - stabilisation, 2 - progression.
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PMC11306331
To dimerize FRB and FKBP, rapalog AP21967 (Takara) was added to a final concentration of 500 nM. To induce expression of FUS-CHOP, doxycycline was added to a final concentration of 1 μg/mL. To fully dissolve droplets, 1,6-hexanediol was dissolved in DMEM and added to a final concentration of 10%.
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PMC10854447
Found: C, 68.35; H, 4.88; N, 21.89.
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PMC10243817
The cytoplasmic and nucleus proteins of nasal epithelial cells obtained from patients with eosinophilic CRSwNP were extracted separately as previously described with minor modifications (54).
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PMC9429973
Secondary objective was to explore influenceable variables in the decision making process.
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PMC11116779
However, the expression of SOD2, the manganese-dependent, mitochondrial isoform, reached a maximum induction level already at the exposition to the lower concentration of PS-NPs (i.e., 10 μg/mL), suggesting that cytoplasm could be more interested and sensitive to an exogenous stimulus such as PS-NPs exposure.
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PMC10882807
We used lipofectamine 3000 and P3000 (Invitrogen, USA) for plasmid overexpression and lipofectamine 3000 for siRNA transfection according to the manufacturer’s instructions.
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PMC11477621
Compound 5e incorporating a 2-benzoylpyrrole cap exhibited comparable inhibitory effects to SAHA.
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PMC10213179
Flow cytometry was used for selected sequences synthesized with a 5′-Cyan5 moiety (BioSpring, Frankfurt, Germany).
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PMC11628904
In all cases, neutrophils and macrophages were identified by the presence of a fluorescence transgene driven by a cell type‐specific promoter.
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PMC8143558
Thus, soapy plants, either in their natural form or through incorporation in commercial products, may be a relevant additional weapon to assist communities to improve hand hygiene and contribute to curbing COVID-19 and other communicable infections.
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PMC9105697
Firstly, a subtype-specific (i.e., SS) panel was designed (Supplementary Figure S1A) which encompassed breakpoint regions and exons of genes that are hotspot regions in SS .
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PMC11506827
The mean fluorescence intensity (MFI) was calculated by analyzing the mean X value of the fluorescence intensity.
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PMC10589262
G Cell viability of GIST cells treated with 0.1 µM TG and PF was measured after 24 and 48 h. H Immunoprecipitation of GIST cell lysates was performed with a control IgG or KIT antibody, and western blotting was performed against chaperones.
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PMC11585565
The top panel displays amino acid alterations corresponding to reported JS variants, while the lower panel shows the functionally characterized residues based on 3D structural determination.
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PMC11773391
The primers for MGMT were as follows: forward primer, 5′‐GTT TTC CAG CAA GAG TCG TTC‐3′ and reverse primer, 5′‐GCT GCT AAT TGC TGG TAA GAA A‐3′. The primers for β‐actin were as follows: forward primer, 5′‐CCT GGC ACC CAG CAC AAT‐3′ and reverse primer, 5′‐GGG CCG GAC TCG TCA TAC‐3′. Pre‐sterilised coverslips were placed in six‐well plates, and A375 cells were seeded on the coverslips.
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PMC11380329
Cell nuclei were stained with 4,6-diamidino-2-phenylindole (DAPI) for 3 min at room temperature.
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PMC11394227
PDI has previously been actively studied to study the folding efficiency of disulfide bonds within CHO cells.
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PMC10968586
Osteosarcoma is a primary malignant bone tumor historically known for its extremely low survival rates even in the case of surgical resection/amputation, which have been improved by the introduction of neoadjuvant and adjuvant chemotherapy .
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PMC10529414
.
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PMC11476222
However, not all columns can efficiently separate gangliosides and other lipid species in a single run.
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PMC9325715
The data is constituent with the molecular docking analysis which indicates the highest probability for Fe binding to glutamic acid.
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