OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11773391	Cells were incubated at 37°C with 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "incubated", "at", "37", "°", "C", "with", "5", "%", "CO2", ...
PMC10890055	The mechanical alloying was performed for 4 h in ZrO2 vessels under an argon-protective atmosphere (purity 99.95%) using a Retsch E-Max milling machine with 800 rotations per minute (RPM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11566417	The pathogenesis of bacterial infections often results from tissue damage caused by host immune responses rather than direct bacterial activity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "pathogenesis", "of", ...
PMC11774112	To verify whether polymerization affects the binding ability to miRNA 34a, DTT (a reducing agent analogous to glutathione) was added to break the disulfide bonds.34 The results showed that PHRD had a weaker miRNA 34a binding affinity in the presence of DTT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11745600	This study is expected to contribute essential basic information for the clinical application of islet cell transplantation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "is", "expected", "to", "co...
PMC11626627	p < .05, p < .01, *p < .001, ns, not significant compared to the controls, and Scale bar: 200 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11075223	DC.,	[ { "tags": [ "O", "O", "O" ], "tokens": [ "DC", ".", "," ] } ]
PMC11657695	C Event-free survival probability (Kaplan Meier curve) of Ewing sarcoma patients depending on KCNA2 expression (high or low).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "Event-f...
PMC9454852	The red/green ratio after BOLD-100 treatment was significantly lower with respect to the untreated cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "red/green", "ratio", "after", "BOLD-100", "treatment", ...
PMC9429973	Other reasons for discontinuing therapy included progression of MDS/CMML (n=6), transformation to AML (n=4), SCT (n=4), and social reasons (n=1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11335267	On the contrary, glucose intolerance in Alx3-deficient mice reversed when animals were fed with HFD (Fig. 2F), showing blood glucose levels similar to those observed in SCD-fed wild type mice (compare Fig. 2F with 2E) and significantly lower than those observed in wild type mice fed on a HFD (Fig. 2G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11707577	Even if the use of absorption intensity to quantify the exact number of oligothiophene molecules contained in a nanoparticle is not rigorous (many approximations must be taken in account), considering the initial M13EGFR concentration and the molar extinction coefficient of the oligothiophene derivative, we can estimate an average number of 416 TM molecules attached to the capsid of the M13EGFR phage in a M13EGFR(TNP) (Figure 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11122631	Subfraction C5D (13.5 mg) was also separated by reverse-phase HPLC (phenyl hexyl column) isocratically eluted by 75% methanol to yield compound 7 (1.0 mg).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11423992	XCC20, RRID: CVCL_E2U5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "XCC20", ",", "RRID", ":", "CVCL_E2U5", ")", "." ] } ]
PMC11568601	DESeq2 software was utilized to normalize the number of genes in each sample, calculate fold changes, and test for significant differences based on a negative binomial distribution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Blina related AEs in prephase were as expected (83% of pts had ≥1 AE and 10% had ≥1 SAE (hepatotoxicity 3 pts, pain lymph node 1, CRS 1, pneumonia 1, renal insufficiency 1)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: The combination of diverse screening approaches may reveal novel vulnerabilities specific for individual mutations frequently recurring in CLL patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":...
PMC8728081	SEM of Kajjali, b) TEM of Kajjali, c) XPS of Hg 4f region of Kajjali, d) SEM of Rasasindura, e) TEM of Rasasindura, and f) XPS of Hg 4f region of Rasasindura and g) XRD of Kajjali and Rasasindura.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9430052	Methods: Patients (pts) with r/r B-NHL were eligible to be enrolled.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Patients", "(", "pts", ")", "with", "r/r", ...
PMC11469524	n = 3), but no upregulation by p38 inhibitor alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "3", ")", ",", "but", "no", "upregulation", "by", "p38", "i...
PMC11661040	Compared with the CGREF1 knockdown group, the reduced cell proliferation induced by CGREF1 knockdown was reversed with the use of wnt signaling pathway activator (Fig. 5F-I).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10656496	The CytoScan HD assay uses 750,000 SNP probes and 1.9 million non-polymorphic probes to report genome-wide copy number aberrations at a resolution of 25–50 Kb.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10203589	In terms of exploring the clinical relevance of FGF18 to EC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "terms", "of", "exploring", "the", "clinical", "relevance", "of", "FGF18", "to",...
PMC11533140	Structural features of the PI3K inhibitor BKM-120.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Structural", "features", "of", "the", "PI3", "K", "inhibitor", "BKM-120", "." ] } ]
PMC10919056	Similarly, transwell and wound healing assays demonstrated that cell migration increased significantly after GJA5 and GJB1 were knocked down (Figures 11C, D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11352746	In most instances, the capabilities of the instruments can be tailored to the purchasing agent, which can significantly affect the price of acquisition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8875242	DDI on intestinal ABCB1 are known to have clinical consequences: the inhibition of intestinal ABCB1 has been shown to increase the absorption of dabigatran, talinolol, fexofenadine, or digoxin , while ABCB1 induction reduces exposure to sofosbuvir and dabigatran .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11747467	We used molecular classification systems to categorize MIBC patients based on mRNA expression data obtained from TCGA database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "molecular", "classification", ...
PMC11551844	ICP-MS was performed to confirm the internalization of AuNPs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ICP-MS", "was", "performed", "to", "confirm", "the", "internalization", "of", "AuNPs", "." ] } ]
PMC8345486	Their responses to metallacarborane-bearing adenosine derivative 23, alone or in combination with cisplatin, were determined using an ATP viability assay intended for 3D large structures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11701801	Other SWI/SNF complex components are also deficient in various cancers (3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "SWI/SNF", "complex", "components", "are", "also", "deficient", "in...
PMC11290772	The proportion of native NK cells within PBMCs differs, ranging from 5% to 20% [27–29] and varies in terms of proliferative potential.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11545737	Furthermore, IL-1β and IL-18 secretion was shown to be reduced in H. pylori-infected AGS cells when treated with emodin, as well as the activation of caspase-1 and GSDMD, and the translocation of VacA .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8009078	The drug-likeness and pharmacokinetic parameters were assessed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "drug-likeness", "and", "pharmacokinetic", "parameters", "were", "assessed", "." ] } ]
PMC10291556	Both cell lines were co-incubated for 2.5 h at the ratio of 1:3 (effector/target), harvested, and fixed for 10 min with 4% formaldehyde.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11473843	John Minna (UTSW Medical Center, Dallas, USA)ATCC # CRL-4051 B6.129SS4-kras /J The Jackson Laboratory008179 B6.129P2-Trp53 /J The Jackson Laboratory008462 Recombinant DNA pCMV-VSV-GStewart et al, 2003Addgene Plasmid #8454; RRID:Addgene_8454pCMV-dR8.2 dvprStewart et al, 2003Addgene Plasmid #8455; RRID:Addgene_8455pSpCas9(BB)-2A-GFP (PX458)Ran et al, 2013Addgene Plasmid #48138; RRID:Addgene_48138pLVUHshp53Szulc et al, 2006Addgene plasmid #11653; RRID:Addgene_11653pBABE-ZeoAddgene#1766; RRID:Addgene_1766pBABE-KRASG12D-ZeoThis studyNApLKO.1 hygroAddgene#24150; RRID:Addgene_24150pLKO.1 hygro-shRNA ERK5This studyNATet-PLKO-puroWiederschain et al, 2009Addgene Plasmid #21915; RRID:Addgene_21915Tet-pLKO-puro-shRNA CDK5This studyNApWZL-HygroAddgene#18750; RRID:Addgene_18750pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216540pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216541pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216542pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216543pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216544pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216545pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216546pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216547pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216677 Antibodies Rabbit Monoclonal Anti-Ki67 clone SP6 (IHC: 1/300)Thermo ScientificCat# RM-9106, RRID:AB_2341197Mouse monoclonal Anti-FAK (D-1) (WB: 1/1000)Santa Cruz BiotechnologyCat# sc-271126, RRID:AB_10614323Rabbit monoclonal Anti-RAS (27H5) (WB: 1/1000)Cell Signaling TechnologyCat# 3339, RRID:AB_2269641Mouse monoclonal Anti-β-actin (AC-74) (WB: 1/2000)Sigma-AldrichCat# a-5316, RRID:AB_476743Mouse monoclonal α-tubulin (WB: 1/2000)Sigma-AldrichCat# T6199, RRID:AB_477583Rabbit monoclonal anti-Phospho-STAT3 D8C2Z (Ser727) (WB: 1/1000)Cell Signaling TechnologyCat# 94994, RRID:AB_2800239Rabbit monoclonal Anti-Cyclin D1 (WB: 1/1000)Cell Signaling TechnologyCat# 2978, RRID:AB_2259616Rabbit polyclonal Anti-Phospho-FAK (Tyr397) (WB: 1/1000)Cell Signaling TechnologyCat# 8556, RRID:AB_10891442Rabbit polyclonal Anti-Phospho-FAK (Ser910) (WB: 1/1000)InvitrogenCat# 44-596G, RRID:AB_2533689Rabbit monoclonal Anti-Vimentin (D21H3) (WB: 1/1000)Cell Signaling TechnologyCat# 5741, RRID: AB_10695459Rabbit monoclonal Anti-E-Cadherin (24E10) (WB: 1/1000)Cell Signaling TechnologyCat# 3195, RRID: AB_2291471Rabbit monoclonal Anti-PARP (46D11) (WB: 1/1000)Cell Signaling TechnologyCat# 9532, RRID:AB_659884Rabbit polyclonal Anti-Phospho-FAK (Ser732) (WB: 1/1000)InvitrogenCat# 44-590G, RRID:AB_2533688Rabbit polyclonal Anti-Phospho-H2AX (Ser139) (WB:1/1000)Cell Signaling TechnologyCat# 2577, RRID:AB_2118010Mouse monoclonal Anti-p21 (WB: 1/1000)BD PharmigenCat# 556430, RRID:AB_396414Mouse monoclonal Anti-CDK5 (J-3) (WB: 1/1000)Santa Cruz BiotechnologyCat# sc-6247, RRID:AB_627241Rabbit Anti-phospho-ERK5 (Thr218/Tyr220) (WB: 1/1000)Cell Signaling TechnologyCat# 3371, RRID:AB_2140424Mouse monoclonal Anti- ERK5 (C-7) (WB: 1/1000)Santa Cruz BiotechnologyCat# sc-398015Mouse monoclonal Anti-p53 (DO-1) (WB: 1/1000)Santa Cruz BiotechnologyCat# sc-126, RRID:AB_628082ImmPRESS® HRP Anti-Rabbit IgG (Peroxidase)Vector labsCat# MP-7401, RRID:AB_2336529Goat Anti-mouse Red IRDye 800 CW (WB: 1/10000)LI-CORCat# 926-32210, RRID:AB_621842Goat Anti-mouse Green IRDye 680 RD (WB: 1/10000)LI-CORCat# 926-68070, RRID:AB_10956588Goat Anti-rabbit Red IRDye 800 CW (WB: 1/10000)LI-CORCat# 926-32211, RRID:AB_621843Goat Anti-rabbit Green IRDye 680 RD (WB: 1/10000)LI-CORCat# 926-68071, RRID:AB_10956166Amersham ECL Mouse IgG, HRP-linked whole AbGE Healthcare Life SciencesCat# NA931, RRID:AB_772210Amersham ECL Rabbit IgG, HRP-linked whole AbGE Healthcare Life SciencesCat#NA934, RRID:AB_772206 Oligonucleotides and other sequence-based reagents shRNA target sequence against human ERK5 (MAPK7): GTTCATCTCAGACCCACCTTTSigma-AldrichTRCN0000197264shRNA target sequence against human CDK5: CCTGAGATTGTAAAGTCATTCSigma-AldrichTRCN0000194974shRNA target sequence against human TP53: AGTAGATTACCACTGGAGTCTTAddgeneAddgene plasmid #11653; RRID:Addgene_11653sgRNA FAK #1: 5’-AGAGCAAAAGATTTGTACAC-3’Sigma-AldrichNAsgRNA FAK #2: 5’-ATGTGGGAGATACTGATGCA-3’Sigma-AldrichNART - PCR oligo for Human ERK5 (MAPK7) FW: 5’-AGCAGGTGGCCATCAAGAAG-3’Sigma-AldrichNART - PCR oligo for Human ERK5 (MAPK7) RV: 5’-CAGGACCACGTAGACAGATTT-3’Sigma-AldrichNART- PCR oligo for Human β-ACTIN FW: AGAGCTACGAGCTGCCTGACSigma-AldrichNART-PCR oligo for Human β-ACTIN RV: AGCACTGTGTTGGCGTACAGSigma-AldrichNA Chemicals, enzymes and other reagents TransIT®-293 Transfection ReagentMirus BioCat# MIR2705Immobilon Forte Western HRP SubstrateMilliporeCat# WBUF0500Methyl GreenVector LabsCat# H-3402Annexin V-Atto 633In houseN/APropidium Iodide (PI)InvitrogenCat# P3566PuromycinGibcoCat# A11138-03Hygromycin BInvitrogenCat# 10687010DAB+ solutionDakoCat# Κ3467Doxycycline (1 μg/mL)Fisher BioReagentsCat# BP2653XMD8-92 for in vitroTocris #4132Cat# 4132Seliciclib for in vitroAdipoGenCat# AG-CR1-0006-M001PF-562271SigmaCat# PZ0387VS-4718 (for in vivo 60 mg/Kg per day)MedChemExpressCat# HY-13917MnTMPyP (SOD mimetic)Sigma-AldrichCat# 475872Dihydrorhodamine 123 (DHR)Sigma-AldrichCat# D1054ZeocinInvivoGenCat# ant-zn-1XMD8-92 for in vivo (50 mg/Kg)MedChemExpressCat# HY-14443Seliciclib for in vivo (50 mg/Kg)MedChemExpressCat# HY-30237TransIT®-LT1 Transfection ReagentMirus BioCat# MIR2300PureLink™ RNA Mini KitInvitrogenCat# 12183018APureLink™ DNase KitInvitrogenCat# 12185-010cDNA Synthesis KitThermo ScientificCat# K1622KAPA HotStart Mouse Genotyping KitKapa BiosystemsCat# KK7352FastSybr© greenThermo ScientificCat# 4367659The DeadEnd™ Colorimetric TUNEL SystemPromegaCat# G7130 Software QuPath v.0.1.2 https://qupath.github.io/ FlowJo V10 https://www.flowjo.com/ GraphPad Prism v.7 https://www.graphpad.com/scientific-software/prism/ TIDE: Tracking of Indels by Decomposition http://shinyapps.datacurators.nl/tide/ Compusyn http://www.combosyn.com ImageJ https://imagej.nih.gov/ij/ Biorender https://app.biorender.com fastqc v.0.11.9 http://www.bioinformatics.babraham.ac.uk/projects/fastqc RSeQC v.4.0.0 https://rseqc.sourceforge.net HiSat2 v.2.2.1 http://daehwankimlab.github.io/hisat2/ FeatureCounts v.2.0.1 http://subread.sourceforge.net/ Bioconductor package DESeq2 v1.38.1 https://bioconductor.org/packages/release/bioc/html/DESeq2.html ClusterProfiler v4.6.0 https://bioconductor.org/packages/release/bioc/html/clusterProfiler.html Shiny application v1.6.0 https://shiny.posit.co/ R version 4.2.1 https://www.r-project.org/ Metascape https://metascape.org/gp/index.html#/main/step1 TRRUST https://www.grnpedia.org/trrust/Network_search_form.php Other Reagents and tools table The plasmid pBABE-zeo (Addgene Plasmid #1766; https://www.addgene.org/1766/; RRID:Addgene_1766) was a gift from Hartmut Land & Jay Morgenstern & Bob Weinberg (Morgenstern and Land, 1990).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11319300	These cell types were chosen due to MYEOV expression being proposed as a prognostic factor for these tissue associated cancers (Moreaux et al., 2010; Fang et al., 2019; Shen et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7762347	For fixation the ethanol (1.5 mL of 96% ethanol) was added dropwise during vortexing and the cells were left at 4 °C for two hours and stored until analysis at −20 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10253553	This suggests that ccRCC tumors that have high levels of NDRG1 might grow slower and be more resistant to apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "suggests", "that", ...
PMC10024132	A minimum of 10,000 cells was analyzed from each sample using a flow cytometer (#0500-5009, Guava easyCyte 5 HPL/guavaSoft software version 2.1, Millipore).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In RARA+ ND AML patients ineligible for standard induction therapy, tamibarotene plus azacitidine (aza) led to a CR/CRi rate of 61% and a rapid onset of response (de Botton 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791264	Together, these findings suggest that methylation of LC3B at the K51 residue by SETD7 promotes ubiquitination and degradation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Together", ",", "these", "finding...
PMC11719944	Also, memory T cells are thought to be one of the main contributors to the development of autoimmune diseases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", ",", "memory", ...
PMC11711127	Indeed, anti-CTLA-4 Ab in vivo abrogates Treg contacts with DC, permitting formation of stable DC-effector cell contact that induce proliferation (145).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10605143	Epithelial, compactly packed cells form a protective layer lining the surfaces of organs and cavities throughout the body.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Epithelial", ",", "compactly", "p...
PMC10723784	CBD has low affinity for CB1 and CB2 receptors, acts as an antagonist or a non‐competitive negative allosteric modulator toward CB1 receptors, and as an inverse agonist toward CB2 receptors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11674441	Although the degree of the enhancement of lymphocyte responses against neoantigens after Neo-P vaccine treatment differed among patients, enhanced lymphocyte IFN-γ production was detected against at least one HLA class II-restricted long peptide in all cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6771295	p < 0.001 is indicated with (*), p < 0.01 with (), and p < 0.05 with (*).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6742971	To overcome this disadvantage, peripheral T cells can be genetically engineered to express TCRs or chimeric antigen receptors with a high avidity and excellent specificity for target antigen, as well as costimulatory molecules that provide the T cells with enhanced properties required for effective ACT therapy (20, 21).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Here we report final data for the overall cohort of patients with SID, together with further subgroup analysis for patients aged 18–64 years [adult] and ≥65 years [older adult].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	CHIP-seq uncovered that cellular H3K36me3 level has been showed no significant difference, but a redistribution existed in groups above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CHIP-seq", "uncovered", "tha...
PMC11380329	Human OVCAR4 cells were maintained in Dulbecco’s Modified Eagle Medium (DMEM) with a low content of glucose (1 g/L) and supplemented with 10% fetal bovine serum (FBS), 1 mM glutamine, 1% antibiotics (penicillin-streptomycin) and 1 mM pyruvate at 37 °C under a humidified atmosphere containing 5% CO2.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10507284	The transfected SW982 cells were collected and tested according to the section Materials and Methods.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "transfected", "SW982", "cells", "were", "collecte...
PMC9429973	Favorable response to first-line antibiotherapy was seen in 74,4% of cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Favorable", "response", "to", "first-line", "antibiotherapy", "was", "seen", "in", ...
PMC9429973	There were 2 cases of treatment-related severe AEs (osteonecrosis [n=1]; groin pain [n=1]).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "were", "2", "...
PMC10882807	Hsa_circ_0005397 primers were purchased from Guangzhou (Geneseed, China), and other primers were purchased from Shanghai (Sangon Biotech, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Pts were randomized to 9 cycles of KRd or KTd, and 107 pts received at least one full cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pts", "were", "randomized", ...
PMC10362265	Overall, nine different IL18-IL18BP complexes were generated and placed in the center of a cubic water box with a padding distance of 10 Å. Solvated systems were neutralized to a final concentration of 0.15 M, using Na and Cl counter ions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401350	This phenotype closely mimics AITL patients, for whom no to very few malignant CD4 + PD1 T cells can be found in the circulation, which is the reason why the malignancy is only detected in late stages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In this method,PS is first bound to fluorescent annexinV,and then the residual nonbound annexin is quantified by binding toPS exposed on apoptotic cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721277	The cartridge was pre-conditioned by passing 10 mL of 95% ethanol solution, 10 mL of 50% ethanol solution, and 10 mL of Milli-Q water before the loading of the radiolabeled preparation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	This descriptive analysis included pts initiating study treatment ≥3 months before the cut-off date (15/01/2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "descriptive", "analysis", "included", "pt...
PMC11185260	The scale bars indicate 100 μm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "scale", "bars", "indicate", "100", "μm", ".", "(" ] } ]
PMC9622879	In the first stage, the optimization problem of each home in the community is as follows:42[12pt] $$&min _^ P_(t) E_(t) \\& = min _^P_(t) (E_^(t) - E_^(t) ), $$∑t=1TPi(t)·Ei,Com(t)=min∑t=1TPi(t)·(Ei,Combuy(t)-Ei,Comsell(t)),where43[12pt] $$ P_(t) = P_(t) & E_(t) >0 \\ P_(t) & E_(t) < 0 . }	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10197932	CD137 becomes expressed on primed T and natural killer (NK) cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CD137", "becomes", "expressed", "on", "primed", "T", "and", "natural", ...
PMC8633974	Figure 9 mRNA LNP carriage (rLNP) of HIV-1 TatDE and Cas9 Attenuate Viral Replication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "9", "mRNA", "LNP", "carriage", "(", "r...
PMC9509578	NoNanoparticles (NPs)Chemotherapeutic drugsExperimental modelMechanism of actionRefs1Tween 80 and PEG coated PBCA NPsDoxorubicinHuman colon (SW620 and SW620/Ad300) and NSCLC (NCI-H460 and NCI-H460/MX20)PEG and Tween 80 act as P-gp inhibitors and block the doxorubicin efflux from the cells and doxorubicin mediated toxicity2PLGA NPsDoxorubicin and VerapamilHuman breast cancer (MCF-7 cells)Inhibition of P-gp efflux pump and enhanced accumulation of drugs and cytotoxicity3Nano PEG-ADDCIrinotecan and YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole)Non small cell lung cancer (A549 cells)Downregulation of HIF-1α and VEGF proteins also enhanced intracellular drug retention4Folate-biotin conjugated starch NPssiRNA-IGF1R and DoxorubicinHuman lung carcinoma (A549 cells)Downregulation of IGF1R protein expression and drug uptake and cytotoxicity5HPMA-gelatin NPsDoxorubicin and Glycyrrhetinic acid (GA)Human hepatoma (HepG2 and HepG2/ADR cells) and BLAB/c nude miceP-gp efflux pump downregulation by GA, enhanced mitochondrial ROS generation, higher uptake of drugs in cells and suppression of tumor growth6Folate modified DSPE-MPEG-PLGA NPsPhephobide a (Pba)Human gastric (MKN 28 cells) and nude miceBypass the P-gp efflux pump and elevated levels of intracellular drug accumulation7Hyaluronic acid conjugated PLGA NPsPaclitaxel and FAK specific siRNAHuman ovarian cancer (A2780, A2780-CP20 cells, SKOV3, SKOV3-TR, HeyA8 and HeyA8-MDR cells) and PDX mouse modelFAK gene silencing, enhanced accumulation of drug, bypassing the P-gp efflux pumps and suppression of tumor growth and development in PDX models8PEG-PLA NPsCyclosporin A and GefitinibHuman non-small cell lung cancer (PC-9 and PC-9-GR cells, H1975 cells) and BALB/c mice PC-9-GR and H1975 xenograftsInhibit EGFR tyrosine kinase disturb the downstream STAT3/Bcl-2 signaling transduction of leads to inhibition of cancer cell progression9TPGS-PLGA NPsDoxorubicin and MetforminHuman breast cancer (MCF-7/DOX cells)Inhibit P-gp to reduce drug efflux and enhance intracellular doxorubicin accumulation and reduce the cellular ATP content10Mannosylated albumin NPsDisulfiram/Cu complex and regorafenibHuman cells (HCT8/ADR and HUVEC cells) mouse macrophage cells (RAW 264.7 and L929 cells)Chemosesitization through ROS generation and enhanced apoptotic cell death11FA-PEI-PEG conjugated nanographeneP-gp specific siRNA (siP-gp) and DoxorubicinHuman breast cancer (MCF-7 and MCF-7/ADR cells)siRNA-mediated P-gp gene silencing, enhanced doxorubicin retention and toxicity12Amphiphilic poly-Jug-DA-b-PEG NPsP-gp specific siRNA (siP-gp) and Doxorubicin, JuglaninHuman lung cancer (A549 and H69 cell lines) and nude BLAB/c miceInhibition of P-gp gene silencing, drug uptake, inhibiting tumor growth13Anisamide-PLGA NPsResveratrol and DoxorubicinHuman breast cancer cell lines (MCF-7/ADR, MDA-MB-231/ADR cells) and BALB/c nude miceInhibition of the expression of MDR-linked transporters P-gp, MRP-1, BCRP and downregulation of NF-κB to enhance apoptosis14Chitosan modified TPGS-b-(PCL-ran-PGA) NPssiHIF and CisplatinHuman nasopharyngeal cancer cell line (CNE-2 cells)MDR1/P-gp gene silencing via siHIF gene and enhanced sensitivity of cisplatin to cells15PLGA-TPGS NPsDocetaxel and Poloxamer 235Human breast cancer (MCF-7/TXT cells) and SCID miceP-gp inhibition and docetaxel accumulation and tumor suppression16Chitosan NPsGefitinib and shMDR1 geneGefitinib resistant HeLa cellsshMDR1-mediated anti-DNA enzyme degradation activity and inhibition of MDR1 gene expression17TPGS conjugated chitosan NPsDoxorubicinHuman hepatocarcinoma (HepG2 and BEL-7402) and human breast cancer (MCF-7/DOX cells) and BEL-7402/5-Fu cellsNP-mediated P-gp efflux pump blocking and downregulation of cellular ATP levels18mPEG-b-PLA polymersomesBcl-xL siRNA and DoxorubicinHuman gastric cancer (MKN-45 and MKN-28 cell lines)siRNA-mediated downregulation of Bcl-xL, enhanced intracellular drug retention and reversal of MDR19Chitosan-PBCA NPsCurcumin and DoxorubicinHuman breast cancer MCF-7 and MCF-7/ADR cellsDownregulation of P-gp efflux pump, NF-κB and elevated level of drug retention and cytotoxicity20Folate-PLGA NPsNutlin-3a and CurcuminHuman retinoblastoma Y79 cellsCurcumin-mediated MRP-1 and LRP downregulation via modulation of NF-κB translocation21PLGA NPsDoxorubicinHuman ovarian (SKOV-3) and uterine (MES-SA/Dx5) cellsDrug resistance is overcome via enhancing intracellular drug uptake and nuclear retention22PLGA NPsCurcumin and DoxorubicinHuman leukemia (K562) cellsCurcumin-mediated P-gp inhibition, downregulation of MDR1, NF-κB and Bcl-2 gene expression23AOT-Sodium alginateMethylene blue and DoxorubicinPrimary mammary adenocarcinoma cells (JC cells) and female BALB/c miceMethylene blue acts as P-gp inhibitor, enhances the inhibition of tumor progression and increases apoptotic mechanisms24Dextran sulphate-PLGA hybrid NPsVincristine sulfateHuman breast cancer (MCF-7 and MCF-7/ADR)Inhibition of P-gp efflux ability by blocking of efflux transporter by NPs and enhanced intracellular drug retention25NIPMAm based core–shell hydrogelssiRNA and DocetaxelHuman ovarian cancer cell lines (Hey and SKOV-3 cells)Loss of EGFR expression due to EGFR gene silencing via siRNA for increased sensitivity of docetaxel26Folic acid conjugated hydroxypropyl chitosan NPsAntisense oligodeoxynucleotides as ODNsHuman carcinoma dox resistant cells (KB-A-1 cells) and BALB/c nu/nu KB-A-1 xenograft miceInhibition of expression of MDR1 gene and P-gp efflux pumps27Biotin conjugated PLGA-PEI NPsPaclitaxel and P-gp targeting siRNAPrimary mammary adenocarcinoma cells (JC cells) and female BALB/c miceEnhanced intracellular retention of paclitaxel and silencing of MDR1 gene that encodes for P-gp efflux pump28Biotin-PLGA NPsTariquidar and PaclitaxelOvarian cancer cell lines NCI/ADR-RES cells and BLAB/c miceInhibition of P-gp pump-mediated drug efflux from cells, enhanced drug retention and cytotoxicity and tumor growth inhibition29PLGA NPsVincristine and VerapamilHuman Breast cancer cells (MCF-7/ADR cells)P-gp inhibition via verapamil and elevated intracellular drug retention30PEO-modified PBAE NPsMDR1 gene silencing siRNA and PaclitaxelOvarian cancer (SKOV and SKOV3TR) cellsAnti-MDR1 gene silencing via siRNA leads to drug retention and cytotoxicity in cells31PEO modified PLGA/PBEA blend NPsPaclitaxel and CeramideHuman breast cancer (MCF-7 and MCF-7TR cells) and MCF-7/ADR nu/nu xenograft modelEnhanced intracellular accumulation and lower clearance rate of paclitaxel32PEO-PCL NPsPaclitaxel and C6-ceramideOvarian cencer (SKOV3 and SKOV3TR) and nu/nu xenograft modelDrug combination enhances apoptosis and inhibits tumor progressionLiposomal nanoformulations33TPGS-liposomesDocetaxel and Coumarin-6Human lung cancer (A549 and A549/DDP cells) and nude miceInhibition of P-gp pump activity preventing the efflux of drug from cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10582049	The expression of CXCL12 and IL33 cytokines in the CTHRC1FAP subpopulation was decreased in comparison to that of both the ADH1B and FAPACTA2 clusters (Fig. 3C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11033180	Figure 3Sema5A, Plexin A1 and Plexin A2 are expressed in enteric neurons in primary cultures of rat gut(A) Triple immunolabeling for Sema5A (green), Hu (red), and β3-tubulin (blue) at 12 days of culture.(B) Double labeling of Plexin A1 (green) with Hu (red) at 12 days of culture.(C) Double labeling of Plexin A2 (green) with Hu (red) at 12 days of culture.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11513571	Figure 4rhTSLP enhanced in vitro production of specific-IgG against MERS-CoV. PBMCs from healthy subjects were stimulated with rSP in the presence or absence of rhTSLP for 10 days (n=4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The induction regimen is based on the combination melphalan-prednisone-thalidomide (MPT) or melphalan-prednisone (MP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "induction", "regimen", "is", "based", ...
PMC9429973	Therefore, inclusion of additional patients will be a priority during the continuation of the study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "inclusion", "of", "additional", "pat...
PMC11481779	Our approach makes the predicted heatmaps almost indistinguishable from the real data, which we have measured using Fréchet inception distance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "approach", ...
PMC11738017	It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", ...
PMC10926885	In light of the association between immune infiltration, MSI, TMB, tumour purity and NDE1 expression level that we previously examined, we hypothesise that NDE1 may have some bearing on the sensitivity to tumour immunotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We explore the effect of low RBC counts on the potency of TXA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "explore", "the", "effect", "of", "low", "RBC", "counts", "on", ...
PMC11541241	SA can enter the F. oxysporum cells and efficiently arrest hyphal growth, sporular production, and pathogenicity of this pathogen (Li et al., 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594074	After the final washing step, the cells were resuspended in PBS, and the results were read on a flow cytometer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "the...
PMC11269792	ChunJuan Wang and JinHua Yuan analyzed the data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ChunJuan", "Wang", "and", "JinHua", "Yuan", "analyzed", "the", "data", "." ] } ]
PMC11760643	The complement pathway is comprised of a network of over 30 plasma proteolytic enzymes that behave in a cascade‐like manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "complement", "pathway...
PMC11591030	As shown in Figure 6, the AOP-treated group increased the gene expression of Nrf2 and its downstream target genes (SOD, GPx, and CAT) in the PBLs compared to the CON group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11562028	Compared with the control group (Re-CDs, 0 μg mL), the S phase arrest rate of the A498 cells in the highest administered group (Re-CDs, 90 μg mL) was ∼62.6% ± 10.5% (p < 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", ...
PMC6600592	The levels of HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) in the supernatant of the HepG2.2.15 cells were determined by the enzyme-linked immunosorbent assay (ELISA) according to the manufacturer’s protocol (Shanghai Kehua Biotech Co., Ltd., Shanghai, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC10745221	Taken together, these results suggest that changes in protein arginine methylation may not be major contributors to the Hoffman effect and that other consequences of methionine addiction may be more important in the metastasis and malignancy of osteosarcoma and potentially other cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Together, these data indicate that mitapivat has the potential to improve HRQoL in pts with PK deficiency who are not regularly transfused.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Togethe...
PMC11657744	Cells were serum-deprived for 24 h to induce cilia formation, fixed, and stained with antibodies against acetylated α-tubulin (Ac-tub, green), γ-tubulin (γ-tub, red), and DAPI (blue) for nuclear staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11766350	72 h post-transfection, cell viability was measured by trypan blue staining on the LUNA-II Automated Cell Counter (Logos Biosystems, Villeneuve d’Ascq, France).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7022782	Therefore, ICG-loaded NPs were characterized in terms of size and fluorescence properties, with special attention to the stabilization effect of ICG resulting from its association with PECA-NPs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594641	The loss of both Rab27A and Rab27B resulted in impaired A375 motility, but the invasive character and the generation of sEVs remained unaffected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC9429973	Five-year cumulative incidence (CI) of relapse was 41.7% and was independently associated with previous lines of treatment (p=0.015), disease phase at transplant (25.7% for CR1, 50% for CR2, and 100% for relapsed/refractory disease, p=0.007), and chronic GVHD (p=0.004).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: 1.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "1", "." ] } ]
PMC9583612	We make several critical observations.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "make", "several", "critical", "observations", "." ] } ]
PMC11555465	Xu et al (29) used CRISPR/CRISPR associated protein 9 technology to create an uracil auxotroph T. gondii RH strain with orotidine 5′-monophosphate decarboxylase gene deletion (RH-Δompdc).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11707577	Confocal microscopy images of cells after incubation for 45 min with M13EGFR(TNP) (A–C) or HSA‐TM bioconjugates (D–F) at equivalent carrier concentration (1 nm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11621493	Heat maps displaying the z-score of PE, PPE, EtherPE, EtherPC, HexCER, CER, and SM subspecies were labeled by the number of C-atoms in fatty acids and the total number of double bonds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11789597	KEGG enrichment analysis revealed that CAV1 mainly regulates metabolism, especially amino acid metabolism (Figure 5F,G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "KEGG", "enrichment", "analys...
PMC11258145	For this reason, in the work the effects of the presence of curcumin on the membranes were studied for three systems, i.e.: (1) single-component models—monolayers of single lipids differing in the saturation of fatty acids` residues: DOPC, DPPC (the main class of animal cell lipids) and cholesterol (a lipid of a different chemical nature—steroid, abundantly found in animal cells); (2) multi-component monolayers with the lipid composition of HL-60 and SK-N-SH cell membranes and (3) native membranes—in vitro cells of the HL-60 and SK-N-SH lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706776	G Expression of KCNN1 in tumor-derived cell lines. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G", "Expression", "of", "KCNN1", "in", "tumor-derived", "cell", "lines", ".", "*" ] } ]
PMC11483468	Cells were treated with PBS, T-GFP, or various concentrations of GST-TAT-LPTS290-328 protein for the indicated times. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "...
PMC8540692	Thus, the aim of this study was to analyze CCM and NaBu both separately and as a combination treatment using three GBM cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11773391

Cells were incubated at 37°C with 5% CO2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "incubated", "at", "37", "°", "C", "with", "5", "%", "CO2", ...

PMC10890055

The mechanical alloying was performed for 4 h in ZrO2 vessels under an argon-protective atmosphere (purity 99.95%) using a Retsch E-Max milling machine with 800 rotations per minute (RPM).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11566417

The pathogenesis of bacterial infections often results from tissue damage caused by host immune responses rather than direct bacterial activity .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "pathogenesis", "of", ...

PMC11774112

To verify whether polymerization affects the binding ability to miRNA 34a, DTT (a reducing agent analogous to glutathione) was added to break the disulfide bonds.34 The results showed that PHRD had a weaker miRNA 34a binding affinity in the presence of DTT.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11745600

This study is expected to contribute essential basic information for the clinical application of islet cell transplantation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "is", "expected", "to", "co...

PMC11626627

p < .05, **p < .01, ***p < .001, ns, not significant compared to the controls, and Scale bar: 200 μm.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11075223

DC.,

[ { "tags": [ "O", "O", "O" ], "tokens": [ "DC", ".", "," ] } ]

PMC11657695

C Event-free survival probability (Kaplan Meier curve) of Ewing sarcoma patients depending on KCNA2 expression (high or low).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "Event-f...

PMC9454852

The red/green ratio after BOLD-100 treatment was significantly lower with respect to the untreated cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "red/green", "ratio", "after", "BOLD-100", "treatment", ...

PMC9429973

Other reasons for discontinuing therapy included progression of MDS/CMML (n=6), transformation to AML (n=4), SCT (n=4), and social reasons (n=1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11335267

On the contrary, glucose intolerance in Alx3-deficient mice reversed when animals were fed with HFD (Fig. 2F), showing blood glucose levels similar to those observed in SCD-fed wild type mice (compare Fig. 2F with 2E) and significantly lower than those observed in wild type mice fed on a HFD (Fig. 2G).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11707577

Even if the use of absorption intensity to quantify the exact number of oligothiophene molecules contained in a nanoparticle is not rigorous (many approximations must be taken in account), considering the initial M13EGFR concentration and the molar extinction coefficient of the oligothiophene derivative, we can estimate an average number of 416 TM molecules attached to the capsid of the M13EGFR phage in a M13EGFR(TNP) (Figure 1C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11122631

Subfraction C5D (13.5 mg) was also separated by reverse-phase HPLC (phenyl hexyl column) isocratically eluted by 75% methanol to yield compound 7 (1.0 mg).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11423992

XCC20, RRID: CVCL_E2U5).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "XCC20", ",", "RRID", ":", "CVCL_E2U5", ")", "." ] } ]

PMC11568601

DESeq2 software was utilized to normalize the number of genes in each sample, calculate fold changes, and test for significant differences based on a negative binomial distribution.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Blina related AEs in prephase were as expected (83% of pts had ≥1 AE and 10% had ≥1 SAE (hepatotoxicity 3 pts, pain lymph node 1, CRS 1, pneumonia 1, renal insufficiency 1)).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Summary/Conclusion: The combination of diverse screening approaches may reveal novel vulnerabilities specific for individual mutations frequently recurring in CLL patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":...

PMC8728081

SEM of Kajjali, b) TEM of Kajjali, c) XPS of Hg 4f region of Kajjali, d) SEM of Rasasindura, e) TEM of Rasasindura, and f) XPS of Hg 4f region of Rasasindura and g) XRD of Kajjali and Rasasindura.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9430052

Methods: Patients (pts) with r/r B-NHL were eligible to be enrolled.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Patients", "(", "pts", ")", "with", "r/r", ...

PMC11469524

n = 3), but no upregulation by p38 inhibitor alone.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "3", ")", ",", "but", "no", "upregulation", "by", "p38", "i...

PMC11661040

Compared with the CGREF1 knockdown group, the reduced cell proliferation induced by CGREF1 knockdown was reversed with the use of wnt signaling pathway activator (Fig. 5F-I).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10656496

The CytoScan HD assay uses 750,000 SNP probes and 1.9 million non-polymorphic probes to report genome-wide copy number aberrations at a resolution of 25–50 Kb.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC10203589

In terms of exploring the clinical relevance of FGF18 to EC.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "terms", "of", "exploring", "the", "clinical", "relevance", "of", "FGF18", "to",...

PMC11533140

Structural features of the PI3K inhibitor BKM-120.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Structural", "features", "of", "the", "PI3", "K", "inhibitor", "BKM-120", "." ] } ]

PMC10919056

Similarly, transwell and wound healing assays demonstrated that cell migration increased significantly after GJA5 and GJB1 were knocked down (Figures 11C, D).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11352746

In most instances, the capabilities of the instruments can be tailored to the purchasing agent, which can significantly affect the price of acquisition.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC8875242

DDI on intestinal ABCB1 are known to have clinical consequences: the inhibition of intestinal ABCB1 has been shown to increase the absorption of dabigatran, talinolol, fexofenadine, or digoxin , while ABCB1 induction reduces exposure to sofosbuvir and dabigatran .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11747467

We used molecular classification systems to categorize MIBC patients based on mRNA expression data obtained from TCGA database.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "molecular", "classification", ...

PMC11551844

ICP-MS was performed to confirm the internalization of AuNPs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ICP-MS", "was", "performed", "to", "confirm", "the", "internalization", "of", "AuNPs", "." ] } ]

PMC8345486

Their responses to metallacarborane-bearing adenosine derivative 23, alone or in combination with cisplatin, were determined using an ATP viability assay intended for 3D large structures.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11701801

Other SWI/SNF complex components are also deficient in various cancers (3).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "SWI/SNF", "complex", "components", "are", "also", "deficient", "in...

PMC11290772

The proportion of native NK cells within PBMCs differs, ranging from 5% to 20% [27–29] and varies in terms of proliferative potential.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11545737

Furthermore, IL-1β and IL-18 secretion was shown to be reduced in H. pylori-infected AGS cells when treated with emodin, as well as the activation of caspase-1 and GSDMD, and the translocation of VacA .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8009078

The drug-likeness and pharmacokinetic parameters were assessed.

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PMC10291556

Both cell lines were co-incubated for 2.5 h at the ratio of 1:3 (effector/target), harvested, and fixed for 10 min with 4% formaldehyde.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11473843

John Minna (UTSW Medical Center, Dallas, USA)ATCC # CRL-4051 B6.129SS4-kras /J The Jackson Laboratory008179 B6.129P2-Trp53 /J The Jackson Laboratory008462 Recombinant DNA pCMV-VSV-GStewart et al, 2003Addgene Plasmid #8454; RRID:Addgene_8454pCMV-dR8.2 dvprStewart et al, 2003Addgene Plasmid #8455; RRID:Addgene_8455pSpCas9(BB)-2A-GFP (PX458)Ran et al, 2013Addgene Plasmid #48138; RRID:Addgene_48138pLVUHshp53Szulc et al, 2006Addgene plasmid #11653; RRID:Addgene_11653pBABE-ZeoAddgene#1766; RRID:Addgene_1766pBABE-KRASG12D-ZeoThis studyNApLKO.1 hygroAddgene#24150; RRID:Addgene_24150pLKO.1 hygro-shRNA ERK5This studyNATet-PLKO-puroWiederschain et al, 2009Addgene Plasmid #21915; RRID:Addgene_21915Tet-pLKO-puro-shRNA CDK5This studyNApWZL-HygroAddgene#18750; RRID:Addgene_18750pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216540pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216541pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216542pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216543pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216544pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216545pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216546pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216547pWZL-hygro-FAKThis studyDeposited at Addgene, plasmid #216677 Antibodies Rabbit Monoclonal Anti-Ki67 clone SP6 (IHC: 1/300)Thermo ScientificCat# RM-9106, RRID:AB_2341197Mouse monoclonal Anti-FAK (D-1) (WB: 1/1000)Santa Cruz BiotechnologyCat# sc-271126, RRID:AB_10614323Rabbit monoclonal Anti-RAS (27H5) (WB: 1/1000)Cell Signaling TechnologyCat# 3339, RRID:AB_2269641Mouse monoclonal Anti-β-actin (AC-74) (WB: 1/2000)Sigma-AldrichCat# a-5316, RRID:AB_476743Mouse monoclonal α-tubulin (WB: 1/2000)Sigma-AldrichCat# T6199, RRID:AB_477583Rabbit monoclonal anti-Phospho-STAT3 D8C2Z (Ser727) (WB: 1/1000)Cell Signaling TechnologyCat# 94994, RRID:AB_2800239Rabbit monoclonal Anti-Cyclin D1 (WB: 1/1000)Cell Signaling TechnologyCat# 2978, RRID:AB_2259616Rabbit polyclonal Anti-Phospho-FAK (Tyr397) (WB: 1/1000)Cell Signaling TechnologyCat# 8556, RRID:AB_10891442Rabbit polyclonal Anti-Phospho-FAK (Ser910) (WB: 1/1000)InvitrogenCat# 44-596G, RRID:AB_2533689Rabbit monoclonal Anti-Vimentin (D21H3) (WB: 1/1000)Cell Signaling TechnologyCat# 5741, RRID: AB_10695459Rabbit monoclonal Anti-E-Cadherin (24E10) (WB: 1/1000)Cell Signaling TechnologyCat# 3195, RRID: AB_2291471Rabbit monoclonal Anti-PARP (46D11) (WB: 1/1000)Cell Signaling TechnologyCat# 9532, RRID:AB_659884Rabbit polyclonal Anti-Phospho-FAK (Ser732) (WB: 1/1000)InvitrogenCat# 44-590G, RRID:AB_2533688Rabbit polyclonal Anti-Phospho-H2AX (Ser139) (WB:1/1000)Cell Signaling TechnologyCat# 2577, RRID:AB_2118010Mouse monoclonal Anti-p21 (WB: 1/1000)BD PharmigenCat# 556430, RRID:AB_396414Mouse monoclonal Anti-CDK5 (J-3) (WB: 1/1000)Santa Cruz BiotechnologyCat# sc-6247, RRID:AB_627241Rabbit Anti-phospho-ERK5 (Thr218/Tyr220) (WB: 1/1000)Cell Signaling TechnologyCat# 3371, RRID:AB_2140424Mouse monoclonal Anti- ERK5 (C-7) (WB: 1/1000)Santa Cruz BiotechnologyCat# sc-398015Mouse monoclonal Anti-p53 (DO-1) (WB: 1/1000)Santa Cruz BiotechnologyCat# sc-126, RRID:AB_628082ImmPRESS® HRP Anti-Rabbit IgG (Peroxidase)Vector labsCat# MP-7401, RRID:AB_2336529Goat Anti-mouse Red IRDye 800 CW (WB: 1/10000)LI-CORCat# 926-32210, RRID:AB_621842Goat Anti-mouse Green IRDye 680 RD (WB: 1/10000)LI-CORCat# 926-68070, RRID:AB_10956588Goat Anti-rabbit Red IRDye 800 CW (WB: 1/10000)LI-CORCat# 926-32211, RRID:AB_621843Goat Anti-rabbit Green IRDye 680 RD (WB: 1/10000)LI-CORCat# 926-68071, RRID:AB_10956166Amersham ECL Mouse IgG, HRP-linked whole AbGE Healthcare Life SciencesCat# NA931, RRID:AB_772210Amersham ECL Rabbit IgG, HRP-linked whole AbGE Healthcare Life SciencesCat#NA934, RRID:AB_772206 Oligonucleotides and other sequence-based reagents shRNA target sequence against human ERK5 (MAPK7): GTTCATCTCAGACCCACCTTTSigma-AldrichTRCN0000197264shRNA target sequence against human CDK5: CCTGAGATTGTAAAGTCATTCSigma-AldrichTRCN0000194974shRNA target sequence against human TP53: AGTAGATTACCACTGGAGTCTTAddgeneAddgene plasmid #11653; RRID:Addgene_11653sgRNA FAK #1: 5’-AGAGCAAAAGATTTGTACAC-3’Sigma-AldrichNAsgRNA FAK #2: 5’-ATGTGGGAGATACTGATGCA-3’Sigma-AldrichNART - PCR oligo for Human ERK5 (MAPK7) FW: 5’-AGCAGGTGGCCATCAAGAAG-3’Sigma-AldrichNART - PCR oligo for Human ERK5 (MAPK7) RV: 5’-CAGGACCACGTAGACAGATTT-3’Sigma-AldrichNART- PCR oligo for Human β-ACTIN FW: AGAGCTACGAGCTGCCTGACSigma-AldrichNART-PCR oligo for Human β-ACTIN RV: AGCACTGTGTTGGCGTACAGSigma-AldrichNA Chemicals, enzymes and other reagents TransIT®-293 Transfection ReagentMirus BioCat# MIR2705Immobilon Forte Western HRP SubstrateMilliporeCat# WBUF0500Methyl GreenVector LabsCat# H-3402Annexin V-Atto 633In houseN/APropidium Iodide (PI)InvitrogenCat# P3566PuromycinGibcoCat# A11138-03Hygromycin BInvitrogenCat# 10687010DAB+ solutionDakoCat# Κ3467Doxycycline (1 μg/mL)Fisher BioReagentsCat# BP2653XMD8-92 for in vitroTocris #4132Cat# 4132Seliciclib for in vitroAdipoGenCat# AG-CR1-0006-M001PF-562271SigmaCat# PZ0387VS-4718 (for in vivo 60 mg/Kg per day)MedChemExpressCat# HY-13917MnTMPyP (SOD mimetic)Sigma-AldrichCat# 475872Dihydrorhodamine 123 (DHR)Sigma-AldrichCat# D1054ZeocinInvivoGenCat# ant-zn-1XMD8-92 for in vivo (50 mg/Kg)MedChemExpressCat# HY-14443Seliciclib for in vivo (50 mg/Kg)MedChemExpressCat# HY-30237TransIT®-LT1 Transfection ReagentMirus BioCat# MIR2300PureLink™ RNA Mini KitInvitrogenCat# 12183018APureLink™ DNase KitInvitrogenCat# 12185-010cDNA Synthesis KitThermo ScientificCat# K1622KAPA HotStart Mouse Genotyping KitKapa BiosystemsCat# KK7352FastSybr© greenThermo ScientificCat# 4367659The DeadEnd™ Colorimetric TUNEL SystemPromegaCat# G7130 Software QuPath v.0.1.2 https://qupath.github.io/ FlowJo V10 https://www.flowjo.com/ GraphPad Prism v.7 https://www.graphpad.com/scientific-software/prism/ TIDE: Tracking of Indels by Decomposition http://shinyapps.datacurators.nl/tide/ Compusyn http://www.combosyn.com ImageJ https://imagej.nih.gov/ij/ Biorender https://app.biorender.com fastqc v.0.11.9 http://www.bioinformatics.babraham.ac.uk/projects/fastqc RSeQC v.4.0.0 https://rseqc.sourceforge.net HiSat2 v.2.2.1 http://daehwankimlab.github.io/hisat2/ FeatureCounts v.2.0.1 http://subread.sourceforge.net/ Bioconductor package DESeq2 v1.38.1 https://bioconductor.org/packages/release/bioc/html/DESeq2.html ClusterProfiler v4.6.0 https://bioconductor.org/packages/release/bioc/html/clusterProfiler.html Shiny application v1.6.0 https://shiny.posit.co/ R version 4.2.1 https://www.r-project.org/ Metascape https://metascape.org/gp/index.html#/main/step1 TRRUST https://www.grnpedia.org/trrust/Network_search_form.php Other Reagents and tools table The plasmid pBABE-zeo (Addgene Plasmid #1766; https://www.addgene.org/1766/; RRID:Addgene_1766) was a gift from Hartmut Land & Jay Morgenstern & Bob Weinberg (Morgenstern and Land, 1990).

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PMC11319300

These cell types were chosen due to MYEOV expression being proposed as a prognostic factor for these tissue associated cancers (Moreaux et al., 2010; Fang et al., 2019; Shen et al., 2021).

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PMC7762347

For fixation the ethanol (1.5 mL of 96% ethanol) was added dropwise during vortexing and the cells were left at 4 °C for two hours and stored until analysis at −20 °C.

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PMC10253553

This suggests that ccRCC tumors that have high levels of NDRG1 might grow slower and be more resistant to apoptosis.

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PMC10024132

A minimum of 10,000 cells was analyzed from each sample using a flow cytometer (#0500-5009, Guava easyCyte 5 HPL/guavaSoft software version 2.1, Millipore).

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PMC9429973

In RARA+ ND AML patients ineligible for standard induction therapy, tamibarotene plus azacitidine (aza) led to a CR/CRi rate of 61% and a rapid onset of response (de Botton 2020).

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PMC11791264

Together, these findings suggest that methylation of LC3B at the K51 residue by SETD7 promotes ubiquitination and degradation.

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PMC11719944

Also, memory T cells are thought to be one of the main contributors to the development of autoimmune diseases.

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PMC11711127

Indeed, anti-CTLA-4 Ab in vivo abrogates Treg contacts with DC, permitting formation of stable DC-effector cell contact that induce proliferation (145).

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PMC10605143

Epithelial, compactly packed cells form a protective layer lining the surfaces of organs and cavities throughout the body.

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PMC10723784

CBD has low affinity for CB1 and CB2 receptors, acts as an antagonist or a non‐competitive negative allosteric modulator toward CB1 receptors, and as an inverse agonist toward CB2 receptors.

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PMC11674441

Although the degree of the enhancement of lymphocyte responses against neoantigens after Neo-P vaccine treatment differed among patients, enhanced lymphocyte IFN-γ production was detected against at least one HLA class II-restricted long peptide in all cases.

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PMC6771295

p < 0.001 is indicated with (***), p < 0.01 with (**), and p < 0.05 with (*).

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PMC6742971

To overcome this disadvantage, peripheral T cells can be genetically engineered to express TCRs or chimeric antigen receptors with a high avidity and excellent specificity for target antigen, as well as costimulatory molecules that provide the T cells with enhanced properties required for effective ACT therapy (20, 21).

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PMC9429973

Here we report final data for the overall cohort of patients with SID, together with further subgroup analysis for patients aged 18–64 years [adult] and ≥65 years [older adult].

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PMC9429973

CHIP-seq uncovered that cellular H3K36me3 level has been showed no significant difference, but a redistribution existed in groups above.

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PMC11380329

Human OVCAR4 cells were maintained in Dulbecco’s Modified Eagle Medium (DMEM) with a low content of glucose (1 g/L) and supplemented with 10% fetal bovine serum (FBS), 1 mM glutamine, 1% antibiotics (penicillin-streptomycin) and 1 mM pyruvate at 37 °C under a humidified atmosphere containing 5% CO2.

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PMC10507284

The transfected SW982 cells were collected and tested according to the section Materials and Methods.

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PMC9429973

Favorable response to first-line antibiotherapy was seen in 74,4% of cases.

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PMC9429973

There were 2 cases of treatment-related severe AEs (osteonecrosis [n=1]; groin pain [n=1]).

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PMC10882807

Hsa_circ_0005397 primers were purchased from Guangzhou (Geneseed, China), and other primers were purchased from Shanghai (Sangon Biotech, China).

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PMC9429973

Pts were randomized to 9 cycles of KRd or KTd, and 107 pts received at least one full cycle.

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PMC10362265

Overall, nine different IL18-IL18BP complexes were generated and placed in the center of a cubic water box with a padding distance of 10 Å. Solvated systems were neutralized to a final concentration of 0.15 M, using Na and Cl counter ions.

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PMC11401350

This phenotype closely mimics AITL patients, for whom no to very few malignant CD4 + PD1 T cells can be found in the circulation, which is the reason why the malignancy is only detected in late stages.

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PMC9429973

In this method,PS is first bound to fluorescent annexinV,and then the residual nonbound annexin is quantified by binding toPS exposed on apoptotic cells.

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PMC11721277

The cartridge was pre-conditioned by passing 10 mL of 95% ethanol solution, 10 mL of 50% ethanol solution, and 10 mL of Milli-Q water before the loading of the radiolabeled preparation.

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PMC9429973

This descriptive analysis included pts initiating study treatment ≥3 months before the cut-off date (15/01/2022).

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PMC11185260

The scale bars indicate 100 μm. (

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PMC9622879

In the first stage, the optimization problem of each home in the community is as follows:42[12pt] $$&min _^ P_(t) E_(t) \\& = min _^P_(t) (E_^(t) - E_^(t) ), $$∑t=1TPi(t)·Ei,Com(t)=min∑t=1TPi(t)·(Ei,Combuy(t)-Ei,Comsell(t)),where43[12pt] $$ P_(t) = P_(t) & E_(t) >0 \\ P_(t) & E_(t) < 0 . }

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PMC10197932

CD137 becomes expressed on primed T and natural killer (NK) cells.

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PMC8633974

Figure 9 mRNA LNP carriage (rLNP) of HIV-1 TatDE and Cas9 Attenuate Viral Replication.

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PMC9509578

NoNanoparticles (NPs)Chemotherapeutic drugsExperimental modelMechanism of actionRefs1Tween 80 and PEG coated PBCA NPsDoxorubicinHuman colon (SW620 and SW620/Ad300) and NSCLC (NCI-H460 and NCI-H460/MX20)PEG and Tween 80 act as P-gp inhibitors and block the doxorubicin efflux from the cells and doxorubicin mediated toxicity2PLGA NPsDoxorubicin and VerapamilHuman breast cancer (MCF-7 cells)Inhibition of P-gp efflux pump and enhanced accumulation of drugs and cytotoxicity3Nano PEG-ADDCIrinotecan and YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole)Non small cell lung cancer (A549 cells)Downregulation of HIF-1α and VEGF proteins also enhanced intracellular drug retention4Folate-biotin conjugated starch NPssiRNA-IGF1R and DoxorubicinHuman lung carcinoma (A549 cells)Downregulation of IGF1R protein expression and drug uptake and cytotoxicity5HPMA-gelatin NPsDoxorubicin and Glycyrrhetinic acid (GA)Human hepatoma (HepG2 and HepG2/ADR cells) and BLAB/c nude miceP-gp efflux pump downregulation by GA, enhanced mitochondrial ROS generation, higher uptake of drugs in cells and suppression of tumor growth6Folate modified DSPE-MPEG-PLGA NPsPhephobide a (Pba)Human gastric (MKN 28 cells) and nude miceBypass the P-gp efflux pump and elevated levels of intracellular drug accumulation7Hyaluronic acid conjugated PLGA NPsPaclitaxel and FAK specific siRNAHuman ovarian cancer (A2780, A2780-CP20 cells, SKOV3, SKOV3-TR, HeyA8 and HeyA8-MDR cells) and PDX mouse modelFAK gene silencing, enhanced accumulation of drug, bypassing the P-gp efflux pumps and suppression of tumor growth and development in PDX models8PEG-PLA NPsCyclosporin A and GefitinibHuman non-small cell lung cancer (PC-9 and PC-9-GR cells, H1975 cells) and BALB/c mice PC-9-GR and H1975 xenograftsInhibit EGFR tyrosine kinase disturb the downstream STAT3/Bcl-2 signaling transduction of leads to inhibition of cancer cell progression9TPGS-PLGA NPsDoxorubicin and MetforminHuman breast cancer (MCF-7/DOX cells)Inhibit P-gp to reduce drug efflux and enhance intracellular doxorubicin accumulation and reduce the cellular ATP content10Mannosylated albumin NPsDisulfiram/Cu complex and regorafenibHuman cells (HCT8/ADR and HUVEC cells) mouse macrophage cells (RAW 264.7 and L929 cells)Chemosesitization through ROS generation and enhanced apoptotic cell death11FA-PEI-PEG conjugated nanographeneP-gp specific siRNA (siP-gp) and DoxorubicinHuman breast cancer (MCF-7 and MCF-7/ADR cells)siRNA-mediated P-gp gene silencing, enhanced doxorubicin retention and toxicity12Amphiphilic poly-Jug-DA-b-PEG NPsP-gp specific siRNA (siP-gp) and Doxorubicin, JuglaninHuman lung cancer (A549 and H69 cell lines) and nude BLAB/c miceInhibition of P-gp gene silencing, drug uptake, inhibiting tumor growth13Anisamide-PLGA NPsResveratrol and DoxorubicinHuman breast cancer cell lines (MCF-7/ADR, MDA-MB-231/ADR cells) and BALB/c nude miceInhibition of the expression of MDR-linked transporters P-gp, MRP-1, BCRP and downregulation of NF-κB to enhance apoptosis14Chitosan modified TPGS-b-(PCL-ran-PGA) NPssiHIF and CisplatinHuman nasopharyngeal cancer cell line (CNE-2 cells)MDR1/P-gp gene silencing via siHIF gene and enhanced sensitivity of cisplatin to cells15PLGA-TPGS NPsDocetaxel and Poloxamer 235Human breast cancer (MCF-7/TXT cells) and SCID miceP-gp inhibition and docetaxel accumulation and tumor suppression16Chitosan NPsGefitinib and shMDR1 geneGefitinib resistant HeLa cellsshMDR1-mediated anti-DNA enzyme degradation activity and inhibition of MDR1 gene expression17TPGS conjugated chitosan NPsDoxorubicinHuman hepatocarcinoma (HepG2 and BEL-7402) and human breast cancer (MCF-7/DOX cells) and BEL-7402/5-Fu cellsNP-mediated P-gp efflux pump blocking and downregulation of cellular ATP levels18mPEG-b-PLA polymersomesBcl-xL siRNA and DoxorubicinHuman gastric cancer (MKN-45 and MKN-28 cell lines)siRNA-mediated downregulation of Bcl-xL, enhanced intracellular drug retention and reversal of MDR19Chitosan-PBCA NPsCurcumin and DoxorubicinHuman breast cancer MCF-7 and MCF-7/ADR cellsDownregulation of P-gp efflux pump, NF-κB and elevated level of drug retention and cytotoxicity20Folate-PLGA NPsNutlin-3a and CurcuminHuman retinoblastoma Y79 cellsCurcumin-mediated MRP-1 and LRP downregulation via modulation of NF-κB translocation21PLGA NPsDoxorubicinHuman ovarian (SKOV-3) and uterine (MES-SA/Dx5) cellsDrug resistance is overcome via enhancing intracellular drug uptake and nuclear retention22PLGA NPsCurcumin and DoxorubicinHuman leukemia (K562) cellsCurcumin-mediated P-gp inhibition, downregulation of MDR1, NF-κB and Bcl-2 gene expression23AOT-Sodium alginateMethylene blue and DoxorubicinPrimary mammary adenocarcinoma cells (JC cells) and female BALB/c miceMethylene blue acts as P-gp inhibitor, enhances the inhibition of tumor progression and increases apoptotic mechanisms24Dextran sulphate-PLGA hybrid NPsVincristine sulfateHuman breast cancer (MCF-7 and MCF-7/ADR)Inhibition of P-gp efflux ability by blocking of efflux transporter by NPs and enhanced intracellular drug retention25NIPMAm based core–shell hydrogelssiRNA and DocetaxelHuman ovarian cancer cell lines (Hey and SKOV-3 cells)Loss of EGFR expression due to EGFR gene silencing via siRNA for increased sensitivity of docetaxel26Folic acid conjugated hydroxypropyl chitosan NPsAntisense oligodeoxynucleotides as ODNsHuman carcinoma dox resistant cells (KB-A-1 cells) and BALB/c nu/nu KB-A-1 xenograft miceInhibition of expression of MDR1 gene and P-gp efflux pumps27Biotin conjugated PLGA-PEI NPsPaclitaxel and P-gp targeting siRNAPrimary mammary adenocarcinoma cells (JC cells) and female BALB/c miceEnhanced intracellular retention of paclitaxel and silencing of MDR1 gene that encodes for P-gp efflux pump28Biotin-PLGA NPsTariquidar and PaclitaxelOvarian cancer cell lines NCI/ADR-RES cells and BLAB/c miceInhibition of P-gp pump-mediated drug efflux from cells, enhanced drug retention and cytotoxicity and tumor growth inhibition29PLGA NPsVincristine and VerapamilHuman Breast cancer cells (MCF-7/ADR cells)P-gp inhibition via verapamil and elevated intracellular drug retention30PEO-modified PBAE NPsMDR1 gene silencing siRNA and PaclitaxelOvarian cancer (SKOV and SKOV3TR) cellsAnti-MDR1 gene silencing via siRNA leads to drug retention and cytotoxicity in cells31PEO modified PLGA/PBEA blend NPsPaclitaxel and CeramideHuman breast cancer (MCF-7 and MCF-7TR cells) and MCF-7/ADR nu/nu xenograft modelEnhanced intracellular accumulation and lower clearance rate of paclitaxel32PEO-PCL NPsPaclitaxel and C6-ceramideOvarian cencer (SKOV3 and SKOV3TR) and nu/nu xenograft modelDrug combination enhances apoptosis and inhibits tumor progressionLiposomal nanoformulations33TPGS-liposomesDocetaxel and Coumarin-6Human lung cancer (A549 and A549/DDP cells) and nude miceInhibition of P-gp pump activity preventing the efflux of drug from cells.

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PMC10582049

The expression of CXCL12 and IL33 cytokines in the CTHRC1FAP subpopulation was decreased in comparison to that of both the ADH1B and FAPACTA2 clusters (Fig. 3C).

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PMC11033180

Figure 3Sema5A, Plexin A1 and Plexin A2 are expressed in enteric neurons in primary cultures of rat gut(A) Triple immunolabeling for Sema5A (green), Hu (red), and β3-tubulin (blue) at 12 days of culture.(B) Double labeling of Plexin A1 (green) with Hu (red) at 12 days of culture.(C) Double labeling of Plexin A2 (green) with Hu (red) at 12 days of culture.

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PMC11513571

Figure 4rhTSLP enhanced in vitro production of specific-IgG against MERS-CoV. PBMCs from healthy subjects were stimulated with rSP in the presence or absence of rhTSLP for 10 days (n=4).

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PMC9429973

The induction regimen is based on the combination melphalan-prednisone-thalidomide (MPT) or melphalan-prednisone (MP).

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PMC9429973

Therefore, inclusion of additional patients will be a priority during the continuation of the study.

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PMC11481779

Our approach makes the predicted heatmaps almost indistinguishable from the real data, which we have measured using Fréchet inception distance .

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PMC11738017

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

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PMC10926885

In light of the association between immune infiltration, MSI, TMB, tumour purity and NDE1 expression level that we previously examined, we hypothesise that NDE1 may have some bearing on the sensitivity to tumour immunotherapy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

We explore the effect of low RBC counts on the potency of TXA.

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PMC11541241

SA can enter the F. oxysporum cells and efficiently arrest hyphal growth, sporular production, and pathogenicity of this pathogen (Li et al., 2022).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11594074

After the final washing step, the cells were resuspended in PBS, and the results were read on a flow cytometer.

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PMC11269792

ChunJuan Wang and JinHua Yuan analyzed the data.

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PMC11760643

The complement pathway is comprised of a network of over 30 plasma proteolytic enzymes that behave in a cascade‐like manner.

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PMC11591030

As shown in Figure 6, the AOP-treated group increased the gene expression of Nrf2 and its downstream target genes (SOD, GPx, and CAT) in the PBLs compared to the CON group.

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PMC11562028

Compared with the control group (Re-CDs, 0 μg mL), the S phase arrest rate of the A498 cells in the highest administered group (Re-CDs, 90 μg mL) was ∼62.6% ± 10.5% (p < 0.001).

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PMC6600592

The levels of HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) in the supernatant of the HepG2.2.15 cells were determined by the enzyme-linked immunosorbent assay (ELISA) according to the manufacturer’s protocol (Shanghai Kehua Biotech Co., Ltd., Shanghai, China).

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PMC10745221

Taken together, these results suggest that changes in protein arginine methylation may not be major contributors to the Hoffman effect and that other consequences of methionine addiction may be more important in the metastasis and malignancy of osteosarcoma and potentially other cancers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Together, these data indicate that mitapivat has the potential to improve HRQoL in pts with PK deficiency who are not regularly transfused.

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PMC11657744

Cells were serum-deprived for 24 h to induce cilia formation, fixed, and stained with antibodies against acetylated α-tubulin (Ac-tub, green), γ-tubulin (γ-tub, red), and DAPI (blue) for nuclear staining.

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PMC11766350

72 h post-transfection, cell viability was measured by trypan blue staining on the LUNA-II Automated Cell Counter (Logos Biosystems, Villeneuve d’Ascq, France).

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PMC7022782

Therefore, ICG-loaded NPs were characterized in terms of size and fluorescence properties, with special attention to the stabilization effect of ICG resulting from its association with PECA-NPs.

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PMC11594641

The loss of both Rab27A and Rab27B resulted in impaired A375 motility, but the invasive character and the generation of sEVs remained unaffected.

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PMC9429973

Five-year cumulative incidence (CI) of relapse was 41.7% and was independently associated with previous lines of treatment (p=0.015), disease phase at transplant (25.7% for CR1, 50% for CR2, and 100% for relapsed/refractory disease, p=0.007), and chronic GVHD (p=0.004).

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PMC9429973

Aims: 1.

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PMC9583612

We make several critical observations.

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PMC11555465

Xu et al (29) used CRISPR/CRISPR associated protein 9 technology to create an uracil auxotroph T. gondii RH strain with orotidine 5′-monophosphate decarboxylase gene deletion (RH-Δompdc).

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PMC11707577

Confocal microscopy images of cells after incubation for 45 min with M13EGFR(TNP) (A–C) or HSA‐TM bioconjugates (D–F) at equivalent carrier concentration (1 nm).

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PMC11621493

Heat maps displaying the z-score of PE, PPE, EtherPE, EtherPC, HexCER, CER, and SM subspecies were labeled by the number of C-atoms in fatty acids and the total number of double bonds.

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PMC11789597

KEGG enrichment analysis revealed that CAV1 mainly regulates metabolism, especially amino acid metabolism (Figure 5F,G).

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PMC11258145

For this reason, in the work the effects of the presence of curcumin on the membranes were studied for three systems, i.e.: (1) single-component models—monolayers of single lipids differing in the saturation of fatty acids` residues: DOPC, DPPC (the main class of animal cell lipids) and cholesterol (a lipid of a different chemical nature—steroid, abundantly found in animal cells); (2) multi-component monolayers with the lipid composition of HL-60 and SK-N-SH cell membranes and (3) native membranes—in vitro cells of the HL-60 and SK-N-SH lines.

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PMC11706776

G Expression of KCNN1 in tumor-derived cell lines. *

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PMC11483468

Cells were treated with PBS, T-GFP, or various concentrations of GST-TAT-LPTS290-328 protein for the indicated times. (

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PMC8540692

Thus, the aim of this study was to analyze CCM and NaBu both separately and as a combination treatment using three GBM cell lines.

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