OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11665584	Both techniques allow identification of the tissue-constituent cell types based on transcriptome gene markers and have allowed us to demonstrate that epidermal keratinocytes expressing PITX1 acquire an oral like state.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11258145	However, the influence of curcumin is significantly more pronounced in the saturated system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "influence", "of", "curcumin", "is", "sign...
PMC11307990	Based on a precisely addressable surface of DNA origami, Ge et al. modified multiple ligands on the surface of DNA origami to bind to tumor cell membrane surface receptors, thereby improving their target ability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11349530	In contrast to acute stimulation, prolonged stimulation by IL-6 and other cytokines activates a suppressive phenotype of myeloid cell lineages - MDSCs (47).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	The best ORR after maintenance was 85% (2% complete response [CR], 24% very good partial response [VGPR], 39% partial response [PR], and 20% MR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11286266	The CNX∆ clone (highlighted into a rectangle dashed box) was selected for subsequent functional experiments in ‘C’.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CNX∆", "cl...
PMC9429973	The overall response rate (ORR) in 65 evaluable pts was 84.6% (55/65), 95% CI 73.5-92.4, and the CR rate was 24.6% (16/65), 95% CI 14.8-36.9.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791264	To achieve exogenous LC3B labeling, cells were transfected with GFP-LC3B either with or without 100 nM bafilomycin A1 for 10 h and then stained with DAPI.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11075223	Novel pharmacological activities on vasodilator , antioxidant, antiosteoporosis and hypolipidemic had also been discovered in recent years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Novel", "pharmacological", "activities", "on...
PMC11576293	1H, Ar-H, J = 2.1 and 8.4 Hz), 7.68 (s, 1H, pyrimidine–C5-H), 7.49 (d.d.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9812014	These results show that palmatine can be a promising multi-stage inhibitor of Zika virus infection .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "show", "that", "palmatine", "can", "be"...
PMC11412721	As mentioned before, the ACKR4-mediated sequestration of CCL21 may impair the CCR7 signaling cascade, which might lead to decreased MYC activity (Shi et al., 2015).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11496491	GPR61, OR14J1, CASTOR3, ST8SIA5, SIX6, IL21.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GPR61", ",", "OR14J1", ",", "CASTOR3", ",", "ST8SIA5", ",", "SIX6", ",", "IL21"...
PMC9429973	Aims: To review all bone marrows performed at a London teaching hospital across 6 months for their indications, eventual diagnosis and aid to patient care.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Alkylating agents, thalidomide, and autologous stem cell transplantation (ASCT) are the mainstay of newly diagnosed multiple myeloma (NDMM) treatment in the public health care system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Although ibrutinib leads to an immune reconstitution, reports have suggested an increased risk of infections (particularly fungal) with ibrutinib in patients with B cell malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5034105	CPE were observed in six of these eight cell lines, including the nonhuman primate (Vero and LLC-MK2), pig (PK-15), rabbit (RK-13), hamster (BHK21) and chicken (DF-1) cell lines, and were most prominent (>50% involvement) in the nonhuman primate, pig, hamster and chicken cell lines (Table 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O"...
PMC11680562	The gel system has efficacy in triggering apoptosis in HeLa cells, with increased cytotoxic effects resulting from the combined action of green-produced CuO NPs and 5-Fu.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10891340	At the same time, autophagy is closely related to ROS and apoptosis, EBV infected cells could negatively impress autophagy by reducing ROS, and induce switch monocytes to apoptosis (Gilardini Montani et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11143482	Based on these fundamental and preclinical studies, numerous clinical trials to identify novel therapeutic strategies against metastasis have been established.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "th...
PMC9429973	In vivo infectious challenge experiments using our model will futher elucidate the importance of KANK1 in the development of MDS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "vivo", "infectious", ...
PMC11360263	Efforts to develop treatments targeting PGCCs have shown promise in preclinical studies but have yet to translate into clinical practice .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Efforts", "to", "develop", ...
PMC11745600	Consequently, these mice serve as valuable models for assessing the function and safety of xenogeneic islets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "these", "mice", "serve", ...
PMC9368503	Notably, our data show that the ICR-SS-1 cell line is significantly more resistant to doxorubicin compared to two established synovial cell lines SYO-1 and HS-SY-II.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "...
PMC6160470	After 10 minutes of incubation at 37 °C, the inorganic phosphate (Pi) released was determined colorimetrically, measuring the absorbance at 600 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Since targeted NGS provides rapid and accurate mutation analysis, this technique could be applied directly to cases of erythrocytosis in which a genetic cause is suspected in order to improve patient and family counseling and initiate early treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767793	Cell growth media, including phosphate buffered saline (PBS), Dulbecco’s Modified Eagle’s Medium (DMEM), Eagle’s Minimum Essential Medium (EMEM), and F12 were obtained from the ATCC (Manassas, VA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10713411	Nomogram model of the 3-/5-/7-year survival probability of patients in KIRC cohort. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nomogram", "model", "of", "the", "3-/5-/7-year", "survival", "probability", ...
PMC11787381	All experiments were carried out in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and followed current European Union regulations (Directive 2010/63/EU).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742431	A confocal microscope was taken by incubating KE proteins with selected cell lines at different times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "confocal", "microscope", "was", "taken", "by", ...
PMC8873393	Color key represents relative expression on a log 2 scale.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Color", "key", "represents", "relative", "expression", "on", "a", "log", "2", "scale", "."...
PMC11089031	In addition, ZNF692 promoted the proliferation and migration of ccRCC cells by targeting G3BP2 and TM9SF2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "ZNF692", "promoted", ...
PMC11578343	Fluctuations in a cell's viscoelastic phenotype have been correlated with a range of biological processes—from cell growth, motility, and behavior , , to the epithelial‐to‐mesenchymal transition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9119314	NOE correlations in 4.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "NOE", "correlations", "in", "4", "." ] } ]
PMC10840195	The mechani sm may need further experiments to elucidate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mechani", "sm", "may", "need", "further", "experiments", "to", "elucidate", "." ] } ]
PMC9964635	Among all of the compounds, 7f, with two methyl groups at positions 2 and 6 of the phenyl ring, displayed the best anti-cancer potential with IC50 = 16.782 µg/mL. Compound 7a, which contains a methyl at position 2 of the phenyl ring, also displayed good anti-cancer activity with an IC50 value of 20.667 µg/mL but less than 7f.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5535901	T-cell activation can be induced by a combination of different agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "T-cell", "activation", "can", "be", "induced", "by", "a", "combination", "of", "diffe...
PMC9429973	JAK2 V617F platelets have been reported to be more activated than CALR mutated platelets, as well as JAK2 mutated patients have a greater thrombotic risk in comparison to other ET groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11237030	Generation and characterization of a CHO-K1/AQP5 human cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Generation", "and", "characterization", "of", "a", "CHO-K1/AQP5", "human", "cell", "line", "." ] } ]
PMC9429973	Results: A total of 112 of transfusion episodes in 61 patients (38% female) were analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "A", "total", ...
PMC11247842	The CNV was segregating in Nordic Holstein and Nordic Red cattle but was not detected in Jersey cattle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CNV", "was", "segregating", "in...
PMC11098378	Cells were stained with CellTracker dye 72 hpi and imaged to calculate fold-change in normalized GFP signal over LacZ (control) siRNA treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11088135	E qRT-PCR was conducted to analyze the mRNA expression of Bax.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", "qRT-PCR", "was", "conducted", "to", "analyze", "the", "mRNA", "expression", "of"...
PMC9429973	Methods: Here, we analysed in 417 patients with PMF or post ET/PV MF incidence and impact on otcome of TP53.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":...
PMC11463018	Purification by flash chromatography (SiO2; ethyl acetate/PE system) yielded the desired compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Purification", "by", "flash", "chromatography", "(", "SiO2", ...
PMC11569208	Each gene was plotted for fold-change and P-value in a volcano plot, notable hits were labeled. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "gene", "was", "plotted", "for"...
PMC7215722	For this purpose, five days post-confluent Caco-2 cells were treated with DSS, and the trans-epithelial electrical resistance (TEER) was evaluated over a period of 24 h. Figure 1B depicts the results of these experiments and demonstrates a significant decrease in the TEER values of DSS-treated Caco-2 cells by approximately 37% after 24 h. Additionally, the osmotic pressure of the DSS solution used (2%) was 320 mOsm/kg, which is not significantly higher than the osmotic pressure of the cell medium alone (325–500 mOsm/kg; data are not shown).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11753949	All recombinant plasmids generated for this study are available from the lead contact with a completed materials transfer agreement.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "recombinant", "plasmids", ...
PMC9429973	Results: There was a statistically significant reduction in risk of death with all 3 ELEVATE-TN treatments (47-month FU data) versus CLL-11 C+O: A+O versus C+OCLL11 (HR=0.23 [95% CI=0.12-0.42, p<0.001]); A versus C+OCLL11 (HR=0.43 [95% CI=0.27-0.70, p<0.001]); C+O versus C+OCLL11 (HR=0.44 [95% CI=0.27-0.71, p<0.001]).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: Persistent hypercoagulability, endotheliopathy and inflammation is still detectable approximately 1 year from recovery in COVID-19 patients, with prior COVID-19 mRNA vaccination not appearing to reduce this risk.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3995603	Calibration curves for the six marker components of A. capillaris (n = 3) Y represents peak area (mAU); x represents concentration (μg/mL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754436	Recent evidence suggests that the novel long noncoding RNA DHRS4 antisense RNA 1 (DHRS4-AS1) serves an important role in cancer progression and metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9516447	Human lung cancer A427 (A) and H460 (B), colon cancer HCT116 (C) and LS180 (D), and pancreatic cancer PANC-1 (E) and CFPAC-1 (F) cells were used.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...
PMC11201245	We added these three times to the average and thus arrived at a limit of 36%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "added", "these", "three", "times", "t...
PMC9712534	Cells harboring H58Y were screened and isolated as single colonies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "harboring", "H58Y", "were", "screened", "and", "isolated", "as", "single", "colonies", ...
PMC11792090	To avoid graft versus host disease (GVHD) and host versus graft (HVG) reactions, immunogenicity factors including T cell receptor (TCR) and human leukocyte antigens (HLAs) need to be suppressed in allogeneic CAR-T cells, also known as universal CAR-T (UCAR-T) cells (7–10).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11536589	In PDAC patients with KRAS mutations, the expression level of MGST1 showed a substantial correlation with the pathological stage (Fig. 4M).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11750712	Isolated TRBC1 or TRBC2 T cells were resuspended at 1 × 10 cells per ml in R10 and stimulated with TransAct (Miltenyi Biotec, 130-111-160), 10 ng ml IL-7 (Miltenyi Biotec, 130-095-367) and 10 ng ml IL-15 (Miltenyi Biotec, 130-095-760).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11297139	The dashed line indicates linkages between EWS/FLI1-bound upregulated cREs and the upregulated genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "dashed", "line", "indicates", "linkages", "between", "EWS/FLI1-bound", ...
PMC11777207	Representative flow plots from tumor draining LN in IgG-treated or atezolizumab-treated animals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "flow", "plots", "from", "tumor", "draining", "LN", "in", "IgG-...
PMC11591030	The mechanism by which AOP alleviates oxidative stress through the Nrf2/Keap1 and NF-κB pathways requires further in-depth investigation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mechanism", "by", "which", "AOP...
PMC10898159	Bromodomain-containing protein 4 (BRD4) is a member of bromodomain and extra-terminal domain-containing (BET) family that include the proteins of BRD2, BRD3, BRD4, and BRDT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5443223	Cells were cultured to 80% confluence and were subsequently transfected with siRNA against the negative control or against CEP164 (Ambion; Thermo Fisher Scientific, Inc.).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9243326	Using the PacBio Sequel II sequencing platform, we obtained 57,428,331,313 bp of original transcript data (about 57 Gb) and a total of 26,658,437 subreads with an average subread length of 2,154 bp and an N50 length of 2,466 bp.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	Although cytolytic proteins were elevated in PTPRZ1-TCR-CD4-T, it remained unclear if PTPRZ1-TCR-CD4-T encountered target cells directly to execute cytotoxicity or to support neighboring cytotoxic PTPRZ1-TCR-CD8-T. Thus, we further unraveled the role of CD4 T cells engineered with the CD8-restricted PTPRZ1 TCR on tumor cell lysis in vitro through enriching CD4 and CD8 T cells via magnetic-activated cell sorting (MACS) post transduction (Fig. 3h, Supplementary Fig. 6g, h).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9776316	We also demonstrated that knockdown of XRCC4 or treatment of the JNK inhibitor decreased cisplatin-resistant tumor growth in the xenograft mouse models, implying the clinical translation of targeting the cJUN-XRCC4 pathway in overcoming cisplatin resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11593031	Subsequently, tandem cytogenetic analysis and total genomic DNA extraction were performed as described below .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "tandem", "cytogenetic", "analysis", "and", ...
PMC10938377	The hanging droplet method was used to grow NCP crystals from buffers containing MnCl2, KCl and K-cacodylate [pH 6.0].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "hangi...
PMC2777936	Little Wnt reporter luciferase activity was detected in basal cultures, but when RA was added, the levels of Wnt-responsive luciferase activity increased markedly over vehicle treated-matched control cells (Figures 1a, 1d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10812665	The residual cell lysate was subsequently collected in a second scraping step in 80% methanol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "residual", "cell", "lysate", "was", "subsequent...
PMC11533140	Phosphoinositide 3-kinases (PI3Ks) belong to a family of lipid kinases that play a key role in cell growth, survival, migration, and differentiation (Bai et al., 2023; Xie et al., 2024; Cantley, 2002; Donahue et al., 2012).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11757131	Compared to the control group, the addition of 0.4–0.8 mM 3-HIB increased the expression levels of mTOR signaling pathway-related proteins and the cell cycle protein, Cyclin D1, while inhibiting the expression of the cell cycle arrest protein, P27.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10850553	Enzymatic cleavage of C5 into C5a by Plasmin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enzymatic", "cleavage", "of", "C5", "into", "C5a", "by", "Plasmin", "." ] } ]
PMC6133382	Twenty-four hours post transfection, a 100-μL aliquot was taken from each of the transfected pools to assay for cell viability and OFP expression using a light microscope (Zeiss Axioskop 2, Zeiss, Jena, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607321	These methods, encompassing linear, VAE-based, and correlation analysis approaches, were capable of integrating all seven omics datasets considered here.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These",...
PMC11240571	Exosomes in the culture medium were extracted by ultracentrifugation, and Western blotting was performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Exosomes", "in", "the", "culture", "medium", "were", "extra...
PMC11495567	The mean number of vinculin punctates and mean cell area with vinculin punctates were quantified using the BZ-800 analyzer and graphed using GraphPad Prism 8.4.3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10291556	Since the high-molecular fraction of the cell extract plays a major role in the reduction of Pt(IV) complexes (Wexselblatt, E.; Gibson, D. J. Inorg.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11063646	Subsequently, we plotted the mean fluorescence uptake at different time points (2, 4, and 8 h) revealing a significant time-dependent increase in the uptake of ANG 12.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Similarly, it was significantly higher in patients who were not in remission for hematological malignancy and who received active chemotherapy (p= 0.010).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11334037	High expression of insulin-like growth factor 2 in gastrointestinal stromal tumors with liver metastasis and closely related to drug resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "High", "expression", "of", ...
PMC9429973	There was no statistical difference in age, gender, EPO, haemoglobin levels and past thrombotic events between the IE group and group with known causes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9046263	Among IDHwt patients alone, a similar trend was seen, though these differences were non-significant (median OS = 12.2 months vs. 11.3 months, p = 0.055) (D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In AML, there exists a low frequency subpopulation of leukaemic stem cells (LSCs) which, similar to their benign Hematopoietic Stem Cell (HSC) counterparts, exhibit stem cell behaviours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11443022	Notably, his wife achieved pregnancy through intracytoplasmic sperm injection (ICSI) utilizing surgically retrieved testicular sperm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "his", "wife", "achieve...
PMC11186948	Statistical test used for comparing means of cells counts (HDAC2 + cells) for five degrees of nuclear localization was multiple t-tests, with significant p value determined through Holm-Sidak method as post-hoc test (α = 0.05) (* p < 0.05; p < 0.01; * p < 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The combined “PET/CT or BMB positive” and an age older than 60y.o.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combined", "“", "PET/CT", "or", "BMB", "positive", "”", ...
PMC11740508	B–I Drugs: Deci,14 nM decitabine; Tala, 5 nM talazoparib; or 14 nM Deci + 5 nM Tala; or DMSO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11551844	In this derivatization reaction, the hydroxyl group is converted into TMS-ether derivatives.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "derivatization", "reaction", ",", "the", "hydroxyl", "group",...
PMC5673955	These data are consistent with the limited replicative potential of T lymphocytes 39.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "are", "consistent", "with", "the", "limited", "replicative...
PMC11658074	h HE, Masson, Sirius Red, and immunofluorescence staining to determine epidermal thickness, dermis thickness, collagen deposition, and SA-β-gal expression in the control group and fat graft group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11708541	PTX caused G1 stop in MCF-7 cells and S phase in other cells.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PTX", "caused", "G1", "stop", "in", "MCF-7", "cells", "and", ...
PMC9429973	Image: Summary/Conclusion: Our results in terms of frequency of mutations in patients remains very similar with previous published data: FLT3+ (28% in our sample compared to 25-39% reported), NMP1 (25% compared to 25-29%), DNMT3A (28% compared to 31%), IDH1 and IDH2 (6%, 15%) compared to 7% and 20%, NRAS (15% compared to 5-22%), WT1 (15% compared to 13%), ASXL1 (6% compared to 7%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11258145	The changes were related to the Cs value for the control system (pure lipid monolayer) assumed as 100% and marked on the graphs with a straight line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8164677	Though there is improvement in 5-year survival, this still remains less than 50% in most prevalent cases, as evident in Figure 1.3 Survival rate is very low unless detected at an early stage but it is often detected at an advanced stage, being asymptomatic at earlier stages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9684669	DMSO was used as a non-treated control. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DMSO", "was", "used", "as", "a", "non-treated", "control", ".", "(" ] } ]
PMC11779605	After primary treatment and control with a platinum- and taxane-based chemotherapy combination, ovarian cancer commonly recurs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "primary", "treatment", "and", "control",...
PMC6835428	The usefulness of subcutaneous mouse models, where the effects on tumor mass are easily measurable, might be limited to pilot studies for the preliminary testing of completely novel drugs and/or delivery systems.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11681005	Compared with those in other cells, scATAC‐inferred HES1 and HES4 expression levels were decreased in TPCS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compared", "with", "those", "in", "other", ...
PMC11792888	Cell proliferation is based on the progression of the cell cycle through four phases: gap 1 (G1), DNA synthesis (S), gap 2 (G2), and mitosis (M) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11665584

Both techniques allow identification of the tissue-constituent cell types based on transcriptome gene markers and have allowed us to demonstrate that epidermal keratinocytes expressing PITX1 acquire an oral like state.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11258145

However, the influence of curcumin is significantly more pronounced in the saturated system.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "influence", "of", "curcumin", "is", "sign...

PMC11307990

Based on a precisely addressable surface of DNA origami, Ge et al. modified multiple ligands on the surface of DNA origami to bind to tumor cell membrane surface receptors, thereby improving their target ability.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11349530

In contrast to acute stimulation, prolonged stimulation by IL-6 and other cytokines activates a suppressive phenotype of myeloid cell lineages - MDSCs (47).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

The best ORR after maintenance was 85% (2% complete response [CR], 24% very good partial response [VGPR], 39% partial response [PR], and 20% MR).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11286266

The CNX∆ clone (highlighted into a rectangle dashed box) was selected for subsequent functional experiments in ‘C’.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CNX∆", "cl...

PMC9429973

The overall response rate (ORR) in 65 evaluable pts was 84.6% (55/65), 95% CI 73.5-92.4, and the CR rate was 24.6% (16/65), 95% CI 14.8-36.9.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11791264

To achieve exogenous LC3B labeling, cells were transfected with GFP-LC3B either with or without 100 nM bafilomycin A1 for 10 h and then stained with DAPI.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11075223

Novel pharmacological activities on vasodilator , antioxidant, antiosteoporosis and hypolipidemic had also been discovered in recent years.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Novel", "pharmacological", "activities", "on...

PMC11576293

1H, Ar-H, J = 2.1 and 8.4 Hz), 7.68 (s, 1H, pyrimidine–C5-H), 7.49 (d.d.,

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9812014

These results show that palmatine can be a promising multi-stage inhibitor of Zika virus infection .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "show", "that", "palmatine", "can", "be"...

PMC11412721

As mentioned before, the ACKR4-mediated sequestration of CCL21 may impair the CCR7 signaling cascade, which might lead to decreased MYC activity (Shi et al., 2015).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11496491

GPR61, OR14J1, CASTOR3, ST8SIA5, SIX6, IL21.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GPR61", ",", "OR14J1", ",", "CASTOR3", ",", "ST8SIA5", ",", "SIX6", ",", "IL21"...

PMC9429973

Aims: To review all bone marrows performed at a London teaching hospital across 6 months for their indications, eventual diagnosis and aid to patient care.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Alkylating agents, thalidomide, and autologous stem cell transplantation (ASCT) are the mainstay of newly diagnosed multiple myeloma (NDMM) treatment in the public health care system.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Although ibrutinib leads to an immune reconstitution, reports have suggested an increased risk of infections (particularly fungal) with ibrutinib in patients with B cell malignancies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5034105

CPE were observed in six of these eight cell lines, including the nonhuman primate (Vero and LLC-MK2), pig (PK-15), rabbit (RK-13), hamster (BHK21) and chicken (DF-1) cell lines, and were most prominent (>50% involvement) in the nonhuman primate, pig, hamster and chicken cell lines (Table 3).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O"...

PMC11680562

The gel system has efficacy in triggering apoptosis in HeLa cells, with increased cytotoxic effects resulting from the combined action of green-produced CuO NPs and 5-Fu.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10891340

At the same time, autophagy is closely related to ROS and apoptosis, EBV infected cells could negatively impress autophagy by reducing ROS, and induce switch monocytes to apoptosis (Gilardini Montani et al., 2019).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11143482

Based on these fundamental and preclinical studies, numerous clinical trials to identify novel therapeutic strategies against metastasis have been established.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "th...

PMC9429973

In vivo infectious challenge experiments using our model will futher elucidate the importance of KANK1 in the development of MDS.

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PMC11360263

Efforts to develop treatments targeting PGCCs have shown promise in preclinical studies but have yet to translate into clinical practice .

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PMC11745600

Consequently, these mice serve as valuable models for assessing the function and safety of xenogeneic islets.

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PMC9368503

Notably, our data show that the ICR-SS-1 cell line is significantly more resistant to doxorubicin compared to two established synovial cell lines SYO-1 and HS-SY-II.

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PMC6160470

After 10 minutes of incubation at 37 °C, the inorganic phosphate (Pi) released was determined colorimetrically, measuring the absorbance at 600 nm.

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PMC9429973

Since targeted NGS provides rapid and accurate mutation analysis, this technique could be applied directly to cases of erythrocytosis in which a genetic cause is suspected in order to improve patient and family counseling and initiate early treatment.

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PMC11767793

Cell growth media, including phosphate buffered saline (PBS), Dulbecco’s Modified Eagle’s Medium (DMEM), Eagle’s Minimum Essential Medium (EMEM), and F12 were obtained from the ATCC (Manassas, VA, USA).

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PMC10713411

Nomogram model of the 3-/5-/7-year survival probability of patients in KIRC cohort. (

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PMC11787381

All experiments were carried out in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and followed current European Union regulations (Directive 2010/63/EU).

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PMC11742431

A confocal microscope was taken by incubating KE proteins with selected cell lines at different times.

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PMC8873393

Color key represents relative expression on a log 2 scale.

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PMC11089031

In addition, ZNF692 promoted the proliferation and migration of ccRCC cells by targeting G3BP2 and TM9SF2.

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PMC11578343

Fluctuations in a cell's viscoelastic phenotype have been correlated with a range of biological processes—from cell growth, motility, and behavior , , to the epithelial‐to‐mesenchymal transition.

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PMC9119314

NOE correlations in 4.

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PMC10840195

The mechani sm may need further experiments to elucidate.

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PMC9964635

Among all of the compounds, 7f, with two methyl groups at positions 2 and 6 of the phenyl ring, displayed the best anti-cancer potential with IC50 = 16.782 µg/mL. Compound 7a, which contains a methyl at position 2 of the phenyl ring, also displayed good anti-cancer activity with an IC50 value of 20.667 µg/mL but less than 7f.

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PMC5535901

T-cell activation can be induced by a combination of different agents.

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PMC9429973

JAK2 V617F platelets have been reported to be more activated than CALR mutated platelets, as well as JAK2 mutated patients have a greater thrombotic risk in comparison to other ET groups.

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PMC11237030

Generation and characterization of a CHO-K1/AQP5 human cell line.

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PMC9429973

Results: A total of 112 of transfusion episodes in 61 patients (38% female) were analyzed.

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PMC11247842

The CNV was segregating in Nordic Holstein and Nordic Red cattle but was not detected in Jersey cattle.

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PMC11098378

Cells were stained with CellTracker dye 72 hpi and imaged to calculate fold-change in normalized GFP signal over LacZ (control) siRNA treatments.

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PMC11088135

E qRT-PCR was conducted to analyze the mRNA expression of Bax.

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PMC9429973

Methods: Here, we analysed in 417 patients with PMF or post ET/PV MF incidence and impact on otcome of TP53.

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PMC11463018

Purification by flash chromatography (SiO2; ethyl acetate/PE system) yielded the desired compounds.

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PMC11569208

Each gene was plotted for fold-change and P-value in a volcano plot, notable hits were labeled. (

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PMC7215722

For this purpose, five days post-confluent Caco-2 cells were treated with DSS, and the trans-epithelial electrical resistance (TEER) was evaluated over a period of 24 h. Figure 1B depicts the results of these experiments and demonstrates a significant decrease in the TEER values of DSS-treated Caco-2 cells by approximately 37% after 24 h. Additionally, the osmotic pressure of the DSS solution used (2%) was 320 mOsm/kg, which is not significantly higher than the osmotic pressure of the cell medium alone (325–500 mOsm/kg; data are not shown).

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PMC11753949

All recombinant plasmids generated for this study are available from the lead contact with a completed materials transfer agreement.

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PMC9429973

Results: There was a statistically significant reduction in risk of death with all 3 ELEVATE-TN treatments (47-month FU data) versus CLL-11 C+O: A+O versus C+OCLL11 (HR=0.23 [95% CI=0.12-0.42, p<0.001]); A versus C+OCLL11 (HR=0.43 [95% CI=0.27-0.70, p<0.001]); C+O versus C+OCLL11 (HR=0.44 [95% CI=0.27-0.71, p<0.001]).

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PMC9429973

Image: Summary/Conclusion: Persistent hypercoagulability, endotheliopathy and inflammation is still detectable approximately 1 year from recovery in COVID-19 patients, with prior COVID-19 mRNA vaccination not appearing to reduce this risk.

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PMC3995603

Calibration curves for the six marker components of A. capillaris (n = 3) Y represents peak area (mAU); x represents concentration (μg/mL).

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PMC11754436

Recent evidence suggests that the novel long noncoding RNA DHRS4 antisense RNA 1 (DHRS4-AS1) serves an important role in cancer progression and metastasis.

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PMC9516447

Human lung cancer A427 (A) and H460 (B), colon cancer HCT116 (C) and LS180 (D), and pancreatic cancer PANC-1 (E) and CFPAC-1 (F) cells were used.

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PMC11201245

We added these three times to the average and thus arrived at a limit of 36%.

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PMC9712534

Cells harboring H58Y were screened and isolated as single colonies.

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PMC11792090

To avoid graft versus host disease (GVHD) and host versus graft (HVG) reactions, immunogenicity factors including T cell receptor (TCR) and human leukocyte antigens (HLAs) need to be suppressed in allogeneic CAR-T cells, also known as universal CAR-T (UCAR-T) cells (7–10).

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PMC11536589

In PDAC patients with KRAS mutations, the expression level of MGST1 showed a substantial correlation with the pathological stage (Fig. 4M).

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PMC11750712

Isolated TRBC1 or TRBC2 T cells were resuspended at 1 × 10 cells per ml in R10 and stimulated with TransAct (Miltenyi Biotec, 130-111-160), 10 ng ml IL-7 (Miltenyi Biotec, 130-095-367) and 10 ng ml IL-15 (Miltenyi Biotec, 130-095-760).

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PMC11297139

The dashed line indicates linkages between EWS/FLI1-bound upregulated cREs and the upregulated genes.

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PMC11777207

Representative flow plots from tumor draining LN in IgG-treated or atezolizumab-treated animals.

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PMC11591030

The mechanism by which AOP alleviates oxidative stress through the Nrf2/Keap1 and NF-κB pathways requires further in-depth investigation.

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PMC10898159

Bromodomain-containing protein 4 (BRD4) is a member of bromodomain and extra-terminal domain-containing (BET) family that include the proteins of BRD2, BRD3, BRD4, and BRDT.

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PMC5443223

Cells were cultured to 80% confluence and were subsequently transfected with siRNA against the negative control or against CEP164 (Ambion; Thermo Fisher Scientific, Inc.).

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PMC9243326

Using the PacBio Sequel II sequencing platform, we obtained 57,428,331,313 bp of original transcript data (about 57 Gb) and a total of 26,658,437 subreads with an average subread length of 2,154 bp and an N50 length of 2,466 bp.

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PMC11787355

Although cytolytic proteins were elevated in PTPRZ1-TCR-CD4-T, it remained unclear if PTPRZ1-TCR-CD4-T encountered target cells directly to execute cytotoxicity or to support neighboring cytotoxic PTPRZ1-TCR-CD8-T. Thus, we further unraveled the role of CD4 T cells engineered with the CD8-restricted PTPRZ1 TCR on tumor cell lysis in vitro through enriching CD4 and CD8 T cells via magnetic-activated cell sorting (MACS) post transduction (Fig. 3h, Supplementary Fig. 6g, h).

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PMC9776316

We also demonstrated that knockdown of XRCC4 or treatment of the JNK inhibitor decreased cisplatin-resistant tumor growth in the xenograft mouse models, implying the clinical translation of targeting the cJUN-XRCC4 pathway in overcoming cisplatin resistance.

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PMC11593031

Subsequently, tandem cytogenetic analysis and total genomic DNA extraction were performed as described below .

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PMC10938377

The hanging droplet method was used to grow NCP crystals from buffers containing MnCl2, KCl and K-cacodylate [pH 6.0].

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PMC2777936

Little Wnt reporter luciferase activity was detected in basal cultures, but when RA was added, the levels of Wnt-responsive luciferase activity increased markedly over vehicle treated-matched control cells (Figures 1a, 1d).

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PMC10812665

The residual cell lysate was subsequently collected in a second scraping step in 80% methanol.

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PMC11533140

Phosphoinositide 3-kinases (PI3Ks) belong to a family of lipid kinases that play a key role in cell growth, survival, migration, and differentiation (Bai et al., 2023; Xie et al., 2024; Cantley, 2002; Donahue et al., 2012).

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PMC11757131

Compared to the control group, the addition of 0.4–0.8 mM 3-HIB increased the expression levels of mTOR signaling pathway-related proteins and the cell cycle protein, Cyclin D1, while inhibiting the expression of the cell cycle arrest protein, P27.

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PMC10850553

Enzymatic cleavage of C5 into C5a by Plasmin.

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PMC6133382

Twenty-four hours post transfection, a 100-μL aliquot was taken from each of the transfected pools to assay for cell viability and OFP expression using a light microscope (Zeiss Axioskop 2, Zeiss, Jena, Germany).

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PMC11607321

These methods, encompassing linear, VAE-based, and correlation analysis approaches, were capable of integrating all seven omics datasets considered here.

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PMC11240571

Exosomes in the culture medium were extracted by ultracentrifugation, and Western blotting was performed.

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PMC11495567

The mean number of vinculin punctates and mean cell area with vinculin punctates were quantified using the BZ-800 analyzer and graphed using GraphPad Prism 8.4.3.

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PMC10291556

Since the high-molecular fraction of the cell extract plays a major role in the reduction of Pt(IV) complexes (Wexselblatt, E.; Gibson, D. J. Inorg.

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PMC11063646

Subsequently, we plotted the mean fluorescence uptake at different time points (2, 4, and 8 h) revealing a significant time-dependent increase in the uptake of ANG 12.

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PMC9429973

Similarly, it was significantly higher in patients who were not in remission for hematological malignancy and who received active chemotherapy (p= 0.010).

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PMC11334037

High expression of insulin-like growth factor 2 in gastrointestinal stromal tumors with liver metastasis and closely related to drug resistance.

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PMC9429973

There was no statistical difference in age, gender, EPO, haemoglobin levels and past thrombotic events between the IE group and group with known causes.

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PMC9046263

Among IDHwt patients alone, a similar trend was seen, though these differences were non-significant (median OS = 12.2 months vs. 11.3 months, p = 0.055) (D).

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PMC9429973

In AML, there exists a low frequency subpopulation of leukaemic stem cells (LSCs) which, similar to their benign Hematopoietic Stem Cell (HSC) counterparts, exhibit stem cell behaviours.

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PMC11443022

Notably, his wife achieved pregnancy through intracytoplasmic sperm injection (ICSI) utilizing surgically retrieved testicular sperm.

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PMC11186948

Statistical test used for comparing means of cells counts (HDAC2 + cells) for five degrees of nuclear localization was multiple t-tests, with significant p value determined through Holm-Sidak method as post-hoc test (α = 0.05) (* p < 0.05; ** p < 0.01; *** p < 0.001).

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PMC9429973

The combined “PET/CT or BMB positive” and an age older than 60y.o.

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PMC11740508

B–I Drugs: Deci,14 nM decitabine; Tala, 5 nM talazoparib; or 14 nM Deci + 5 nM Tala; or DMSO.

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PMC11551844

In this derivatization reaction, the hydroxyl group is converted into TMS-ether derivatives.

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PMC5673955

These data are consistent with the limited replicative potential of T lymphocytes 39.

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PMC11658074

h HE, Masson, Sirius Red, and immunofluorescence staining to determine epidermal thickness, dermis thickness, collagen deposition, and SA-β-gal expression in the control group and fat graft group.

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PMC11708541

PTX caused G1 stop in MCF-7 cells and S phase in other cells.

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PMC9429973

Image: Summary/Conclusion: Our results in terms of frequency of mutations in patients remains very similar with previous published data: FLT3+ (28% in our sample compared to 25-39% reported), NMP1 (25% compared to 25-29%), DNMT3A (28% compared to 31%), IDH1 and IDH2 (6%, 15%) compared to 7% and 20%, NRAS (15% compared to 5-22%), WT1 (15% compared to 13%), ASXL1 (6% compared to 7%).

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PMC11258145

The changes were related to the Cs value for the control system (pure lipid monolayer) assumed as 100% and marked on the graphs with a straight line.

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PMC8164677

Though there is improvement in 5-year survival, this still remains less than 50% in most prevalent cases, as evident in Figure 1.3 Survival rate is very low unless detected at an early stage but it is often detected at an advanced stage, being asymptomatic at earlier stages.

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PMC9684669

DMSO was used as a non-treated control. (

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PMC11779605

After primary treatment and control with a platinum- and taxane-based chemotherapy combination, ovarian cancer commonly recurs.

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PMC6835428

The usefulness of subcutaneous mouse models, where the effects on tumor mass are easily measurable, might be limited to pilot studies for the preliminary testing of completely novel drugs and/or delivery systems.

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PMC11681005

Compared with those in other cells, scATAC‐inferred HES1 and HES4 expression levels were decreased in TPCS.

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PMC11792888

Cell proliferation is based on the progression of the cell cycle through four phases: gap 1 (G1), DNA synthesis (S), gap 2 (G2), and mitosis (M) .

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