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OTAR3088
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BioData-CellLine_annotated

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PMC11612315
e Average single-channel open time (left) and open probability (right) (mean ± S.E.M.).
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PMC10958426
The copy number of CNV and heterogeneity of CNV influenced the gene expression should be a unique features of cancer cells since normal cells are diploid and gene expression were precisely regulated.
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PMC10958426
Wilcoxon signed rank test was used for examining whether differences were significant between tumor and normal tissue in each pathway, p values were adjusted by BH. (
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PMC11095939
not significant; **p<0.01; ****p<0.0001 by one-way ANOVA. (
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PMC11502327
Therefore, there is an urgent need to discover and develop new natural medicine preparations with alternative effects.
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PMC11499381
Therefore, we also characterized the effect of V1–154 fusion on CTR alone.
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PMC11612508
Each experiment was conducted a minimum of three times with new samples each time, and the standard deviations were computed from these results.
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PMC9429973
E. Doma, I. Mayer, A. Hoelbl-Kovacic, R. Grausenburger, K. Kollmann, V. Sexl Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Vienna, Austria Background: Preclinical research aims at developing robust methods to maintain, expand and manipulate haematopoietic stem/progenitor cells (HSPC) ex vivo, as these cells are infrequent and their immortalization is hardly achieved.
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PMC11687663
The analysis was performed using the gradient elution & the condition applied were represented in Tables 1S and 2S in S1 File.
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PMC11380329
A total of 5 × 10 cells/well was seeded onto a 96-well plate and incubated at 37 °C.
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PMC9516401
Then, 10 µl of the MTT solution (phosphate buffer, 5 mg/ml) was added to each well.
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PMC9429973
Aims: We present here an extensive study of HDAC6 expression and function during human erythropoiesis.
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PMC11806818
In recent years, research on CTCs separation and detection using microfluidic chips has progressed rapidly, and a variety of technical principles and detection methods have emerged one after another .
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PMC9100622
Cells were checked routinely by PCR for the absence of mycoplasma (VenorGeM qEP; Minerva Biolabs, Berlin, Germany).
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PMC9429973
The safety data are also consistent with those from the HOPE trial.
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PMC11093197
HEK293T (#RCB2002) and MIA‐PACA‐2 (#RCB2094) were purchased from RIKEN BRC.
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PMC11472639
indicates a significant difference from pre-exercise at p < 0.001.
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PMC7612475
In keeping with our hypothesis, depletion of SF3B1 resulted in an increased sensitivity to IR-induced DNA damage comparable to BRCA1 (Fig. 1A; Supplementary Fig. S1A; ref.
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PMC10976516
Yet this is not the case for OV-loaded transformed cells that form solid tumors such as A549 lung adenocarcinoma, MCF-7 breast carcinoma, HeLa cervical carcinoma, and others.
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PMC9672323
Figure 6The effect of drugs on the oxidative activity of T cells in PBMCs.
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PMC9622879
Four types of communal DERs were considered, consisting of PV systems, ESS, wind turbines, and diesel generator.
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PMC9429973
Summary/Conclusion: We have developed a mouse model in order to characterize in vivo chemotherapy resistance depending on niche.
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PMC11470999
Data are presented as mean ± standard deviation.
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PMC9429973
G. Cartron, MD, PhD, E. Bachy, MD, PhD, H. Tilly, MD, N. Daguindau, MD, G.-M. Pica, MD, F. Bijou, MD, C. Mounier, MD, A. M. Clavert, MD, G. L. Damaj, MD, PhD, B. Slama, MD, O. Casasnovas, MD, R. Houot, MD, PhD, K. Bouabdallah, MD, D. Sibon, MD, PhD, O. Fitoussi, MD, N. Morineau, MD, C. Herbaux, MD, PhD, T. Gastinne, MD, L.-M. Fornecker, MD, C. Haioun, MD, PhD, V. Launay, MD, C. Araujo, MD, O. Benbrahim, MD, L. Sanhes, MD, R. Gressin, MD, H. Gonzalez, MD, F. Morschhauser, MD, PhD, L. Xerri, MD, PhD, K. Tarte, PhD, D. Pranger, MD Haematology, CHU de Montpellier, MONTPELLIER Cedex 5; CHU Lyon Sud, Pierre Benite; Centre Henri Becquerel, Rouen; Centre Hospitalier Annecy-Genevois - Site d’Annecy, Pringy Cedex; CH de Chambéry, Chambéry; Institut Bergonié, Bordeaux; Institut de Cancérologie Lucien Neuwirth, St-Priest-en-Jarez; CHU Angers, Angers; CHU Côte de Nacre, Caen; CH d’Avignon - Hôpital Henri Duffaut, Avignon; CHU Dijon - Hôpital d’Enfants, Dijon; CHU Rennes, Rennes; CHU Bordeaux, Bordeaux; Hôpital Necker, Paris; Polyclinique Bordeaux Nord Aquitaine, Bordeaux; CH Départemental Vendée, La Roche sur Yon; CHU Montpellier, Montpellier; CHU de Nantes - Hôtel Dieu, Nantes; Hôpitaux Universitaires de Strasbourg - Hôpital de Hautepierre, Strasbourg; Hôpital Henri Mondor, Créteil; CH de Saint-Brieuc - Hôpital Yves Le Foll, Saint- Brieuc; Centre Hospitalier de la Côte Basque - Hôpital de Bayonne, Bayonne; CHR de la Source, Orléans; Hôpital Saint Jean, Perpignan; CHU de Grenoble - Hôpital Albert Michallon, Grenoble; CH René Dubos, Pontoise; CHRU de Lille - Hôpital Claude Hurriez, Lille; Departement de bio-pathologie, Institut Paoli Calmette, Marseille, France; GHdC, Charleroi, Belgium Background: In low–tumor burden follicular lymphoma (FL), maintenance rituximab (MR) has been shown to improve progression-free survival (PFS) when compared with observation.
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PMC11763111
However, HLA-E and HLA-G have limitations in preventing rejection by allogeneic NK cells, as they do not simultaneously inhibit all NKG2A and KIR2DL NK cell subpopulations.
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PMC11361748
Cells were treated with TPA for 30 min and PLA assays were performed for performed for (A) GFP and RACK1, and (C) RACK1 and phospho-PKCα (S657).
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PMC10589262
The epitope retrieval was conducted with Retrieve-All Antigen 1 (pH 8), followed by blocking with PBS supplemented with 2% normal horse serum and 3% BSA.
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PMC11740573
The exact dosages and methods were based on data available from other experiments .
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PMC9429973
R. Zeiser, C. Schmid, G. Al-Atrash, Y. Xu, H.-J. Weber, L. Eldjerou, S. Weber, L. Widmer, C. Craddock Department of Medicine I, Medical Center, University Freiburg, Freiburg; Department of Hematology and Oncology, Augsburg University Hospital and Medical Faculty, Augsburg, Germany; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston; Oncology Analytics, Novartis Pharmaceutical Corporation, East Hanover, United States of America; Oncology Analytics, Novartis Pharma AG, Basel, Switzerland; Clinical Development, Novartis Pharmaceuticals Corporation, East Hanover, United States of America; Advanced Exploratory Analytics, Novartis Pharma AG, Basel, Switzerland; Centre for Clinical Haematology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom Background: The risk of disease relapse in patients (pts) allografted for acute myeloid leukemia (AML) is high and remains the main cause of transplant failure.
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PMC11388384
E and F) Under the topology-limited diffusion model, distinct cell–cell arrangements give rise to topology-dependent effective diffusion rates.
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PMC11783017
Ⅰ: Control, Ⅱ: PGP, Ⅲ: Mn@PGP, Ⅳ: Cis/Mn@PGP, Ⅴ: Mn/NH@PGP, Ⅵ: Cis/Mn/NH@PGP.
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PMC10538569
HIV-1 gag p24 in the culture supernatants collected at days 3, 6, 9 and 12 post co-culture between mock-, GPI-scFv X5 or AB65-transduced CEMss-CCR5 cells and HIV-1 AD8-captured iDCs. (
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PMC9429973
Transposable elements (TEs) are common in the human genome and, with regard to their ability to change the position in the genome, may represent one of the sources of this instability.
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PMC11737091
After being washed three times, the membranes were incubated with goat anti-rabbit IgG secondary antibodies (Proteintech, SA00001-2, 1:10000 dilution) at room temperature for 1 h. Finally, enhanced chemiluminescence reagents (ECL, Thermo Fisher, Rockford, IL, USA) were used to visualise the signals.
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PMC11011837
The gradient used was as follows: From 0 to 3 min, an isocratic gradient was maintained, with A at 10% and B at 90%.
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PMC9429973
Hemoglobin improved by at least 1.0 g/dL in 48% of patients at 1 month, 42% of patients at 3 months, and 65% of patients at 6 months.
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PMC10743717
Since that literature’s title was found to be ‘Mathematical models for ligand-receptor binding.
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PMC11122631
Using the in silico tool SwissADME (Swiss Institute of Bioinformatics, Lausanne, Switzerland), we predicted the pharmacological potentials of test compounds, including (1) the water solubility (by three kinds of models), pharmacokinetics, (2) drug-likeness, (3) medicinal chemistry property, and (4) oral bioavailability.
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PMC2196094
The very high levels of mRNA for the different proteases actualises an important question concerning the role of MCs during normal tissue maintenance and tissue remodelling.
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PMC9014716
Levels of ABCB1 mRNA and P-gp were detected by qRT-PCR and western blot analysis, respectively.
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PMC9429973
Human brain organoids potentially address some of these drawbacks and may therefore present a complemental approach to study CNS invasion.
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PMC11461874
We have complied with all relevant ethical regulations for animal use.
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PMC11786767
The sample size “N” indicates the number of examined cells.
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PMC11756514
A p-value below 0.05 was considered significant.
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PMC9429973
Summary/Conclusion: The deep and durable responses achieved with teclistamab in patients with highly refractory MM were reaffirmed with data from ~9 months of follow-up.
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PMC11655536
H, I Combination Index (CI) of HA and carfilzomib in RPMI-8226 or ARH-77 cells.
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PMC11727000
Background/Objectives: The enzyme ubiquitin-specific protease 44 (USP44) is a deubiquitinating enzyme with identified physiological roles as a tumor suppressor and an oncogene.
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PMC11224020
Right, median with range of LifeAct nucleus-to-cytosol ratio (N = 3; n = 55 cells in 4 µm (DMSO), n = 70 cells in 3 µm (DMSO), n = 42 cells in 3 µm (CK666)).
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PMC7039683
We used a dual-luciferase reporter assay system (Promega, Madison, WI) and 20/20 n Luminometer (Turner Biosystems, Sunnyvale, CA) to evaluate the luciferase activity following manufacturer’s instructions.
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PMC9429973
Non-infectious comorbidities were registered in 4 of 5 patients with severe COVID-19 form.
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PMC11792090
Measurement of IFN-γ levels secreted by SAP UCAR-T cells from both small-and large-scale production.
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PMC9429973
four patients were classified as GCB pathological subtype, six patients were diagnosed with stage III-IV.
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PMC11472639
Specifically, an individual bout of cycling 15% above anaerobic threshold may move a portion of MRD cells from the bone marrow into the blood, rendering them detectable by EuroFlow flow cytometry.
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PMC3675084
The final concentration of doxorubicin ranged from 0.1–1000 nM. Control wells received ethanol in whole medium equivalent to the maximum final ethanol concentration of drug treated wells.
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PMC7369657
The tumor-inhibition rate was calculated using the following formula: (2)Vcontrol–VtreatmentVcontrol×100%,where V is tumor volume.
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PMC11055443
Therefore, limiting the source of indole production will prevent bacteria from accumulating together and attaching to the surface.
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PMC11612508
10(a-c), The viability of A172 cells at 24- and 48-h post-exposure to GO/CS/IO magnetic microspheres is significantly compromised in the presence and absence of a magnetic field when compared to the untreated control group (P < 0.05 for 24 h and P < 0.01 for 48 h).
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PMC11127909
A Venn diagram of the overlap of EFHD1 or IgG Co-IP binding proteins in 143B cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "A", "Venn", "diagram", "of", "the", "overlap"...
PMC5963610
at days 3, 5, 7, 9, 11 and 13.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "at", "days", "3", ",", "5", ",", "7", ",", "9", ",", "11"...
PMC11155445
Attachment of different groups to the benzene ring at para position showed inhibition activity against α-glucosidase in the following order, methoxy > methyl > chloro > tert-butyl (Fig. 72).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11011837
Following the procedure outlined by Tsugawa H. et al. , lipid semiquantification was performed using the deuterated internal standard (EquiSPLASH Lipidomix) for each lipid class at levels 2 and 3 of the LSI recommendations (see Table S7).
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PMC11389534
In the absence of UFBP1, UFL1 is unstable and lacks activity; however, the presence of UFBP1 gives rise to a stable complex that has the ability to facilitate substrate UFMylation.
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PMC9119314
In addition, 2, 4, 5, and 6 were assessed for the activity against P. berghei sporozoites/Hep G2 cells, and 1, 2, and 6 were tested against late-stage P. falciparum gametocytes; 2 was also evaluated for resilience against resistance development.
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PMC9841531
Lead compound 24 decreased the cell viability of MCT1-expressing cancer cells due to pyruvate and subsequent glucose deprivation and increased the susceptibility of MCT1-expressing cells to the antineoplastic agent 33.
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PMC11522251
p < 0.0001 and ns (not significant) for siHOXB8-2 relative to siNC.
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PMC8041314
In the case of two reported IC50 values or a given IC50 span, the mean was calculated.
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PMC11658074
We subsequently investigated the impact of AT-EVs on the activation of the NF-κB signalling pathway during UVB irradiation.
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PMC9841531
MCT1-expressing cells have an extraordinary energy demand and rely on pyruvate metabolism, through either lactate conversion or pyruvate consumption.
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PMC11752740
After treating both SK-BR3 and MCF10A cell lines for the specified durations (indicated with *), we observed a significant reduction in MDR1 gene expression across all treatment groups when compared to the control group.
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PMC3019555
The amount of HIF-1α mRNA in each fraction was quantified by quantitative RT-PCR (qRT-PCR), and its distribution between translating and nontranslating fractions is shown in Fig. 1 B. In untreated cells, the majority of HIF-1α mRNA cofractionated with actively translating polysomes under both hypoxia (∼74%) and normoxia (∼55%).
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PMC9429973
Patients with isolated adult pLCH have lower relative survival compared to the general population.
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PMC10329074
ns: no significanceTable 2Univariate regression analysis and multivariate analysis of prognostic variables in ccRCC patientsCharacteristicsTotal (N)Odds Ratio (OR)P valueT stage (T2&T3&T4 vs. T1)5301.926 (1.365–2.724) < 0.001N stage (N1 vs. N0)2551.483 (0.535–4.272)0.449M stage (M1 vs. M0)4981.566 (0.963–2.574)0.073Pathologic stage (Stage II&Stage III&Stage IV vs. Stage I)5271.830 (1.297–2.589) < 0.001Primary therapy outcome (SD&PR&CR vs. PD)1380.170 (0.025–0.691)0.027Histologic grade (G2&G3&G4 vs. G1)5222.621 (0.864–9.654)0.107Gender (Male vs. Female)5301.889 (1.317–2.722) < 0.001Race (Black or African American&White vs. Asian)5237.082 (1.248–132.866)0.068Age (> 60 vs. < = 60)5301.062 (0.756–1.494)0.728Serum calcium (Elevated&Low vs. Normal)3630.862 (0.566–1.311)0.488Hemoglobin (Low&Elevated vs. Normal)4501.558 (1.068–2.278)0.022Laterality (Right vs. Left)5290.852 (0.605–1.199)0.359(Progressive disease); SD (stable disease); PR (partial response); CR (Compete response); G1 (Grade 1); G2 (Grade 2); G3 (Grade 3); G4 (Grade 4) Differential YBX3 expression related to clinicopathological characteristics in ccRCC patients of TCGA cohort. (
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PMC11012313
Additionally, previous data demonstrate that LMP1, which is found in Stages II and III of EBV latency, also enhances HIF-1α in a post-transcriptional pathway that requires a key E3 ubiquitin ligase that induces the degradation of prolyl hydroxylases (PHDs) required for HIF-1α breakdown .
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PMC11566417
The supernatants, further enriched for epithelial cells were transferred to a 6-well ultralow attachment plate to enrich for stem/progenitor cells through the formation of mammospheres.
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PMC11748335
Additionally, LTRs and LINEs were found to be enriched in typical peaks.
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PMC11694066
Cells were then fixed in 4% paraformaldehyde for 20 minutes at room temperature, washed twice with PBS, and permeabilized with 0.5% Triton X-100 in PBS for 10 minutes.
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PMC10900886
Retrograde axonal transport of EV-D68 has been shown in human induced pluripotent stem cell-derived motor neurons (10), suggesting that EV-D68 can use peripheral nerves that innervate the respiratory tract to spread to the CNS.
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PMC11269792
Fig. 6CircAPP promotes GIST proliferation and the Warburg effect by regulating the miR-6838-5p/CDV3 axis.
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PMC11670407
P < 0.05, **P < 0.01 vs. the corresponding control OTULIN regulated the protein stability of GPX4 by preventing its proteasomal degradation.
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PMC6642070
The increased blood lactate levels persisted as long as the treatment continues up to 30 weeks (Supplemental Fig. 1a).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "increased", ...
PMC11535726
Kirschsteiniothelialongirostrata can be distinguished from other Kirschsteiniothelia species in having different sizes and shapes of conidiophores, conidiogenous cells and unique features of conidia, such as obpyriform to obclavate, long rostrate, proliferating, with a mucilaginous sheath surrounding the upper part of the apex.
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PMC9429973
In comparison, the life expectancy of inpatients was estimated to be less than 12 months in approximately 49% at medical oncology wards and approximately 37% at internal medicine wards according to the doctors in academic centers.
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PMC9429973
Detailed studies of this patient population are lacking.
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PMC11543935
Other studies showed that the optimal timepoint for measuring the cell viability after an EP was 24 h post treatment.
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PMC11790599
It was supported by the limited colocalization of macropinosomes with the recycling endosome marker Rab11 (Figure 3I).
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PMC6889484
Two CEMSS/D128K clones are shown with lower A3G-D128K levels (0.35× and 0.70×) compared to endogenous A3G expressed in CEM cells (1×).
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PMC7433824
We selected to study two different GBM cell lines (U87 and A172) with different genetic constitutions to elucidate P4 actions in a more detailed manner.
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PMC7452526
Figure 3Figure 4A) particles size distribution, B) A video frame, C) 2D scattergram, D) 3D plot and E) results from NTA for colloidal nanosilver synthesized using aqueous extract of Eucalyptus Camaldulensis leaves.
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PMC9429973
Methods: EPO-induced differentiation of human CD34 progenitors was evaluated following alterations in arginine transport and metabolism by different pharmacological inhibitors and shRNA-mediated knockdown of identified genes.
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PMC9429973
Adjusted ORRs in the IRd vs V-based cohorts were 74.1 (95% CI 66.0–82.2) vs 57.5% (95% CI 47.9–67.1; p<0.0001).
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PMC11078693
Scale bar is 2 μm.
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PMC9429973
Disease stage at enrollment was III-IV in 16 (84%) patients.
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PMC11371747
However, normal cells at a physiological pH (around 7) can be selectively protected by RFC-mediated uptake of systemic l-LV, which has a rapid distribution.
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PMC11768281
They prime macrophages for phagocytosis and signal B cells to produce antibodies against Plasmodium .
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PMC9429973
Aims: The purpose of our study was to compare of venous thromboembolism incidence in multiple myeloma patients receiving lenalidomide-based regimen with rivaroxaban or aspirin thromboprophylaxis.
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PMC8633974
For the first set of experiments, the goal was to assess the route of LNP migration towards the nucleus.
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PMC11705630
To explore the possible effect of GLDC on mtDNA, we performed double-IF staining of heat shock protein 60 (HSP60), a mitochondrial marker, and DNA in ACHN control and GLDC knock-downed cells.
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PMC11271278
Scale bar, 2 µm.
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PMC11794847
The used inhibitors include oligomycin (to measure ATP-linked respiration), FCCP (to measure maximal respiration by uncoupling the electron transport chain), and a combination of rotenone and antimycin A (to shut down mitochondrial respiration and measure non-mitochondrial respiration).
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PMC10079526
The interaction network visualizes fold change via node color as indicated in the scale bar (fold change of: 0.59–12.17) and significance indicated with node size.
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