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OTAR3088
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BioData-CellLine_annotated

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PMC11774112
Scale bar = 50 μm. **
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PMC11190062
Median expression is indicated.
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PMC10840195
Renal cell carcinoma (RCC) is one of the most common malignant tumours of the urinary system, and its mortality ranks sixth in male tumours and eighth in female tumours .
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PMC11694625
The methyl nitronium ion and the methyl cation are powerful methylating agents that can methylate DNA.
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PMC11698348
Loss of Elf5 functions (Fig 3a) in epidermal keratinocytes resulted in significantly increased expression on proliferative genes (Cdk1, Cdk16 and Ccne1,” *p<0.05; **p<0.01, Fig 3b).
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PMC9429973
Image: Summary/Conclusion: Teclistamab in combination with daratumumab is a novel immunotherapy approach that may yield improved clinical efficacy in heavily pretreated patients with RRMM.
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PMC11737091
Representative images of migration assays of 786-O and A498 cells subjected to DBF4 knockdown. (
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PMC11757131
The 3-HIB can promote the process of fatty acid β-oxidation by upregulating the expression of proteins related to fatty acid oxidation, such as ACSL and CAD.
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PMC10506676
According to Miceli et al., STMN1 gene expression is increased in breast cancer and is directly related to tumor size and degree of damage (42).
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PMC3203927
LDA is also commonly used as a dimension reduction method for further classification analysis.
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PMC5673955
The total protein extract from cells (50 μg of total protein) was dissolved in 50 mmol/L Tris‐HCl, pH 6.8, 1% sodium dodecyl sulfate, 2 mmol/L EDTA, 1% 2‐mercaptoethanol, 7.5% glycerol, and denatured by heating at 100⁰C for 10 min.
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PMC11763764
However, to inhibit SORL1 in cancer cells more effectively and more specifically in a clinical setting, we still need to overcome several critical barriers.
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PMC11721587
We expressed a constitutively active Fu (Flag-Fu) in Sf9 cells infected with high MOI (multiplicity of infection).
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PMC10142392
Combining drugs with different activities and administering them simultaneously to the same cell or inflammation area can enhance the effectiveness of the drugs and tumor cytotoxicity.
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PMC11732523
Traction bronchiectasis and a "crazy-paving" pattern are observed.
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PMC11612315
Similarly, compared with vehicle injection, intraplantar CAP injection significantly reduced the PWT in the von Frey test from 30 to 120 min compared with that in the vehicle group (Fig. 3f), whereas mechanical allodynia was dose-dependently alleviated in the groups treated with exendin 9–39 (5 or 10 μg) or BCTC (0.5 μg), a widely used TRPV1 inhibitor.
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PMC9429973
We have shown that extended post-ASCT treatment with carfilzomib, lenalidomide, and dexamethasone (KRd) after KRd induction improved the depth and duration of response (Jasielec et al, Blood 2020), suggesting a benefit of post-ASCT KRd therapy.
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PMC11488203
Western blot analysis of cancer cell lines representing five different tumor entities was performed for the expression of the specific SDF-1 receptors CXCR4 and CXCR7.
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PMC9927933
It is well established that UBE2C/2S E2s couple with APC/C E3 ligase to promote ubiquitylation and degradation of cell cycle regulatory proteins (5).
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PMC11655498
For instance, CRISPRi using the lytic model will produce thousands of essential target genes for EBV reactivation.
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PMC11487720
Morphologically, the WWOXf cell height or thickness was significantly increased during cell division or apoptosis, but the event did not occur in BCD.
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PMC9429973
Among 10 patients prior exposure to BTK inhibitors before RS, 4 patients acquired BTK mutation.
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PMC11527437
A mKRAS-reactive TCR sequence was isolated from an oligoclonal population of T cells in this patient (designated A11Vc).
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PMC3035438
Expression of IgHM and of chimeric IgHG1 detected by RT–PCR in the wild-type parental strain (WT) and a positive chimeric transformant (CX13). (
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PMC9429973
Here, we report on a series of pts receiving a sequential chemotherapy regimen (fludarabine 30 mg/m, amsacrine 100 mg/m, cytarabine 2 g/m (FLAMSA)) and reduced-intensity conditioning (RIC) followed by HSCT as well as prophylactic donor lymphocyte infusions (DLI) as described by Schmid et al (JCO 2005).
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PMC10587429
We demonstrated early and robust reconstitution of human CD45 leukocytes including T cells, B cells, natural killer cells and monocytes.
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PMC11794847
Specifically, the activated T cells seem to possess a more potent ability to impede the growth and movement of these lung cancer cell lines compared to their non-activated counterparts.
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PMC9587866
Prediction of Activity Spectra for Substances (PASS) Analysis The biological activity of these compounds was determined across 3000 pharmacologically active targets in order to elucidate the molecular mechanism of action.
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PMC11064533
As it focuses on one aspect, i.e., the adhesion phenotype for antibiotic tolerances, other possibilities have not been taken into account and should also be explored, whereby bacterial physiology, such as reduced permeability and increased efflux (65), host cell invasion (66), and processes associated with the development and maintenance of cellular adhesion and clumping, may also be a contributing factor in sensitivity to the antibiotics.
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PMC6190245
During all radiation exposures, the cells were preserved in RPMI1640 medium supplemented with 10% FBS and 1% streptomycin/ penicillin.
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PMC10253553
In hepatocellular carcinoma, siRNA-mediated reduction of NDRG1 sensitized cancer cells to doxorubicin-induced apoptosis.
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PMC7215832
Background: RX-3117 (fluorocyclopentenyl-cytosine) is a cytidine analog that inhibits DNA methyltransferase 1 (DNMT1).
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PMC11551844
Ansellone A, a sesterpenoid, was isolated from the nudibranch Cadlina luteomarginata and the sponge Phorbas sp. It activates the cAMP signal transduction pathway without a ligand/receptor binding event and has gained interest due to its activity as an HIV latency-reversing agent (LRA).
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PMC11741577
Absorbance was read on a microplate reader (Molecular Devices, San Jose, CA.
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PMC11699042
ref. ),
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PMC11089031
E the KD of ZNF692 inhibited the migration of Caki-1 cells.
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PMC11098378
For example, the Thoeris system uses TIR domain-containing proteins to produce the cADPR isomer v-cADPR which triggers cell death leading to abortive phage infections in bacteria .
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PMC11655498
Another family of host factors, TLKs, plays a role in the reactivation of EBV during its latent phase, and the knockout of TLKs leads to EBV reactivation (Dillon et al., 2013).
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PMC11755624
Through binding to miR-150-5p, NORAD promotes the proliferation of cardiomyocytes .
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PMC11423992
Despite significant progress in the treatment of BCL over the past two decades, the recurrence rate among BCL patients remains unacceptably high, exceeding 50% even after various therapeutic interventions such as high-dose chemotherapy and Rituximab .
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PMC8540692
Based on the MTT results of each particular cell line, the concentrations of compounds/combination treatment allowing the survival of more than 70% of cells were chosen for further analysis.
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PMC11476837
Cells incubated with 20 µM (HL-60 cells) or 100 µM (HL-60/DR cells) camptothecin (CAM) for 24 h were used as positive controls.
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PMC11767725
They cross-link collagen and elastin fibers in the extracellular matrix, reducing skin elasticity and barrier integrity.oAGEs also impair keratinocyte differentiation and antimicrobial peptide (AMP) production, leaving the skin more susceptible to infections.oThis cascade is particularly pronounced in individuals with T2DM, where AGE accumulation is linked to complications such as poor wound healing, chronic ulcers, and heightened susceptibility to microbial infections.
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PMC11347429
Subsequently, multiple samples from the same participant or the reference samples were removed, and a unique dataset was generated ( Data file 21 for the genotype data, Data file 3 for a description of this sample set, see Table 1 for availability of supplementary data and tables).
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PMC11564322
The mRNA expression was normalized to the GAPDH gene.
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PMC10809689
Reverse phase HPLC (RP-HPLC) was done on an Azura Knauer pump (Germany) and a fluorescence detector (Shimadzu Prominence RF-20 A, Japan) in 350 nm excitation/450 nm emission wavelength criteria by gradient elution on a C18 column (150 * 4.6 mm, 5 μm, Macherey-Nagel, Germany), using Mobile-phase A (1 g K2PO4 + 0.5 g KH2PO4 in 500 mL distilled water), and mobile- phase B (100 mL distilled water, 150 mL acetonitrile, and 300 mL isopropanol) .
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PMC9621239
The number of the significant sites which have higher mutation frequencies, located within the transactivation domain or strongly conserved region are displayed in the Venn diagram. (
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PMC10698968
The nucleolus is the area where ribosome biogenesis, namely the process of ribosome production, takes place in eukaryotic cells.
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PMC11594641
Even in the same malignancy, like melanoma, its activity differed depending on the character of the tumor cell.
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PMC9429973
The observation period (baseline plus follow-up) required ≥2 clinical document records ≥30 days apart, and ≥1 clinical document every 6 months.
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PMC11471157
Outer surface after processing. (
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PMC9429973
The optimized threshold of pretreatment ctDNA load to stratify PFS was 850 hGE/mL of plasma (Figure 1A).
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PMC8540611
Moreover, this difference was not seen when the entire population was analyzed.
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PMC11798926
We then aimed to assess the role of μ2-dependent SynDIG trafficking within neurons.
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PMC8864075
p < 0.01 was the cutoff for displaying the pathways. (
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PMC9927933
Then, the immunocomplexes were washed 5 times with IP lysis buffer before being resolved by SDS-PAGE and analyzed by IB.
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PMC11001582
Mouse models of C9orf72 hexanucleotide repeat expansions have also been generated, taking advantage of either adeno-associated virus-mediated delivery or bacterial artificial chromosome (BAC) integration.
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PMC3019555
Fluorescence intensity was read with a microplate spectrofluorometer (Gemini EM; MDS Analytical Technologies).
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PMC11682525
Conversely, SH-SY5Y neuroblastoma cells displayed a much lower tolerance to hypoxic conditions.
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PMC10093184
p53 protein, commonly known as the “guardian of the genome” is an extraordinary multifunctional protein involved in cellular DNA integrity protection and regulation in normal and tumor cells .
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PMC11674441
However, recent research has revealed the importance of HLA class II-restricted neoantigens that activate CD4-positive helper T cells.
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PMC11697703
The day of vaginal plug detection was designated E0.5, and the day of birth as P0.
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PMC9429973
The total implantation rate was 100%.
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PMC11089031
To characterize the expression of ZNF692 in ccRCC, we examined the correlations between the expression of ZNF692 and the clinicopathological features of ccRCC.
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PMC9429973
Hematocrit, platelets, and leukocytes decreased over time (mean±SD change from baseline to EOT: –5.45±6.66%, –493.6±374.9×10/L, –11.71±8.38×10/L, respectively), and all parameters improved to their target value range.
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PMC8592717
The most famous and one of the most frequently used TCMs is Salvia miltiorrhiza (SM), known as Danshen in Chinese.
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PMC6684588
The differential ability of FST315 (circulating) and FST288 (locally acting) to bind heparan sulfate-containing proteoglycans in the pericellular space is considered to be a key determinant of their different biological activities, including the ability of FST288 to neutralize endogenous activin.
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PMC9429973
The dosing frequency observed in the real-world was consistent with the approved label.
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PMC9429973
Data on the efficacy and prognosis of P53 mutation in diffuse large B-cell tumor patients were extracted, and the associations between P53mutations and clinicopathologic parameters were examined.
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PMC11247842
The variants at BTA20: 22,385,791 (rs110323061) and BTA20: 22,386,425 (rs380944374) are both located in a ncRNA, LOC104975241, within the first intron of the MAP3K1 gene.
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PMC11755519
Moreover, since EVs accumulate in readily available body fluids, they may become a potential biomarker for bladder cancer.
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PMC11461833
HA-progerin-expressing HEK293 cells were treated with STXBP5 sh1 or STXBP5 sh2 for the knockdown of STXBP5 or with shLuci as the control shRNA.
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PMC9024365
The total mean area of GluA1 puncta was not significantly larger compared with the chimeras when co-expressed with SD4.
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PMC11740399
Compound 3K, OXA, and combination therapy treated T24 cells (D) and 5637 cells (D).
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PMC11703896
UNISON UK C18 column of 3 μm diameter and 4.6 mm × 250 mm length was used for the chromatographic separation.
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PMC9429973
Patients received convalescent or vaccinated SARS-CoV-2 plasma in two bags (238 - 337 ml plasma each) from different donors on day 1 and 2 (PLASMA) or standard of care (CONTROL).
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PMC10237474
Alternatively, a tetracycline-inducible HEK293S GnTI stable cell line that expresses a GOI in response to tetracycline and sodium butyrate has also been reported .
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PMC9424261
The membranes were incubated with anti-rabbit IgG, HRP-linked antibody (1:2000, #7071, CST) or anti-mouse IgG, HRP-linked antibody (1:2000, #7076, CST) at room temperature for one hour, and visualized using Clarity Western ECL substrate.
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PMC8414691
Compared to mock- and scramble-treated control cells, SRCAP RNAi-treated cells exhibited a significant increase in mitosis and cytokinesis defects.
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PMC11733919
TEM images showed an anisometric cubic-like shape and an average size of 13.2 ± 1.3 nm of the MNP@OA magnetic core (Figure 2a).
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PMC11718809
The RPM value of each circRNA and miRNA was calculated to quantify circRNAs and miRNAs using HTseq Software (v2.0.3) with the following formula:RPM=number of reads mapping to circRNAsnumber of reads in clean data×106 In this formula, the number of reads mapping to circRNAs and miRNAs includes both TopHat2 (v2.0.9) and TopHat-Fusion (v2.0) mapped reads.
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PMC10605143
The primary antibody was detected using an anti-rat secondary antibody conjugated with AlexaFluor488 (1:200, Invitrogen, Waltham, MA, USA) or an anti-rabbit secondary antibody conjugated with AlexaFluor 488 (1:200, ab150077, Abcam).
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PMC11680391
Supplementary Table S3).
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PMC11380454
Data analysis was performed using FlowJo software.
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PMC11144200
Once each mouse’s tumor grew around 100 mm, the animals were randomized separated into groups and given intravenous treatment with CD8 T cells that had been activated by the DC/tumor fusion vaccination and had been pre-incubated with liposomes or antibodies.
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PMC11772449
PFD was originally found to be an inhibitor of the TGF pathway, so we examined whether pirfenidone sensitizes Sora by acting on the TGF pathway.
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PMC11464982
The rats were killed 48 h after the first dosing and cell suspensions from the bone marrows were prepared for micronucleus analysis.
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PMC10726501
Wound healing assay was carried out to investigate the migratory ability of GIST882 cells. *
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PMC10547921
Compound 119 in the series of analogs maintained high cellular potency, but its current conjugated ADC did not show superior cell-killing ability for the cancer cell lines tested compared to free antibodies.
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PMC10882807
Viral hepatitis, alcohol abuse, and nonalcoholic hepatic steatosis are the main risk factors for HCC .
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PMC11770746
The unencapsulated platinum complex was removed by ultracentrifugation (MWCO: 10 kDa) at 2500 g for 10 min at 4 °C twice, and the samples were stored at 4 °C until usage.
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PMC11747467
When the correlation between p(k) and k exceeded 0.85, an ideal network was further established ( Supplementary Figure S2C ).
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PMC5600151
They reported that PLL G6 is the most favorable transfection agent .
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PMC11748335
These results indicate that long LOCKs in S/I/L-PMDs exhibit distinct characteristics and distribution preferences, in line with the finding that S/I/L-PMD regions possess different genomic characteristics .
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PMC9429973
Ethics approval was obtained (DSRB 2020/00833).
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PMC9388315
To confirm the effects of the aqueous extract of Cinnamon on the reduction of glycolysis, an LDH activity assay was performed.
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PMC7348793
This study also has methodological implications.
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PMC11129910
Genetic abnormalities are common in different cancers.
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PMC9509578
Biogenic AgNPs were revealed to have elevated in-vitro anticancer efficacy, thereby facilitating the reversal of cancer MDR .
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PMC8193046
A detailed analysis of these substructures according to their statistical distribution amongst the 133 known multitarget ABCB1, ABCC1, and ABCG2 inhibitors , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , showed that the substructures isoxazole, imidazole, pyrazole, and pyrrolidine occurred only 1, 3, 1, and 2 times , , , , , , respectively, in these 133 compounds, and were generally only present in 1, 16, 8, and 8 molecules, respectively, of the initial dataset of 1,049 compounds as used in C@PA .
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