OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9429973	Intermediate risk cytogenetics were predominant in patients under 60 years old whereas Unfavourable karyotypes were more frequent in older patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Intermediate", "risk", "cyto...
PMC11509278	The biosynthesis of steroid hormones is also closely related to changes in lipid metabolism and is also a therapeutic intervention point for the treatment of prostate cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640247	Scale bars, (B) 50 μm, (D) 100 μm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "(", "B", ")", "50", "μm", ...
PMC8143558	However, it is also, in most cases unclear whether the saponin values shown in Table 1 are triterpenoid or steroid saponins as they are usually simply termed ‘saponins’ in the literature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806818	The characterization and detection of exosomes after separation helps to identify the morphology, quantity and level of exosome-specific molecular markers, which plays an important role in the early diagnosis, treatment and prognosis of diseases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711663	The other HNSCC sites, such as the oral cavity and oropharynx, are also affected by exposure to those carcinogens and their combination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8740518	BCAAs can also donate nitrogen for glutamate synthesis, which can then be used to synthesize glutamine, important to tumor growth and maintenance (Hutson, Sweatt & LaNoue, 2005).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240448	The prior network topology matrix is presented in Supplementary Table S5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "prior", "network", "topology", "matrix", "is", "presented", "in", "Supplementary", ...
PMC11300085	The results of cell proliferation showed that lower dose of chemerin (25 ng/mL) did not influence the cell growth at any time points, but higher concentrations of chemerin (50 and 100 ng/mL) significantly promoted the proliferation of SK-OV-3 cells after 48 h and 72 h incubation (P < 0.0001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10877303	In this study, 2369 phytoconstituents were enlisted from Japanese medicinal plants, and these compounds were screened against 3C-like protease to identify feasible inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10968586	After 48 h treatment, 500 μM OLE increased the rate of apoptosis in A375 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "After", "48", "h", "treatment", ",", "500", ...
PMC11725127	Recombinant USP2 was incubated with biotin or biotin–GA in the absence or presence of 75 μmol/L or 150 μmol/L of unlabeled GA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9672323	Studies on indomethacin proved the positive effect of this medication on the proliferation of T cells prepared from patients with various types of cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11423992	Jurkat, Clone E6-1 cell line was purchased from the National Collection of Authenticated Cell Cultures (CCRID cat. #	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Jurkat", ...
PMC8753818	Activation of caspases in cancer cells may cause the loss of cell cycle checkpoints and increase the proliferation of these tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activation", ...
PMC11754291	Spectral irradiance of 385 nm (LZ1-00UB0RU4) and 457 nm (LZ1-00B202) LEDs, measured at 12 cm from the spectrophotometer probe (OceanOptics, High-speed Spectrometers, SR2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8557138	However, most of the existing 3D models employ established cell lines that may fail to simulate the in vivo tumoral response that have urged the development of 3D models employing parental tissue-derived cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754094	We developed the ExCas-Analyzer for detecting CRISPR-induced DNA alterations without requiring a supercomputer and that can run on a personal computer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "developed", ...
PMC11741906	A: Top twenty enriched GO terms in the biological process category.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ":", "Top", "twenty", "enriched", "GO", "terms", "in", "the", "biologi...
PMC9429973	Methods: Patients with PV who underwent abdominal computed tomography (CT) and who had palpable splenomegaly at diagnosis from January 1991 to December 2020 at Chungnam National University Hospital were enrolled in the study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11707832	In an independent multi-ethnic cohort, they found that gene expression of MAN2B1 in peripheral monocytes showed a statistically significant association with a reduced upper-lower lobe ratio, whereas the gene expression of MAN1C1 was associated with an increased percentage of emphysema.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5415764	This approach could dramatically improve anticancer drug accumulation in tumor cells25.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "approach", "could", "dramatically", "improve", "anticancer", "drug", "accumulation", ...
PMC7709199	This glycan plays a key role in the assembly of a crystallographic tetramer formed by the interaction of two Ig9 and two Ig7 domains (Fig. 1 ▸ b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9621239	Shannon entropy (Sn) was used to quantify the complexity of HBV X QS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Shannon", "entropy", "(", "Sn", ")", "was", "used", "...
PMC10538569	To determine the phenotype of mDCs, monocyte-derived mDCs were incubated with PE-conjugated anti-CD83, CD86, DC-SIGN or HLA-DR antibodies for 45 min on ice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10812665	A reference library containing the collection of all amplification products was used for assigning read counts to each targeted gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "reference", "library", ...
PMC9436459	0.7 μg/mL (5-FU)Bel-7402n.a.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "0.7", "μg/mL", "(5-FU)Bel-7402n.a", "." ] } ]
PMC9429973	Methods: We retrospectively reviewed the data of 23 patients who were diagnosed with COVID-19 and managed with ECMO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "We", "retrospecti...
PMC11773391	A375 cells were treated with vMF (0.5 or 1 μM) and TMZ (2 mM) for 24 h either alone or in combination, and the number of apoptotic cells was detected by performing PI/Annexin V‐FITC staining (Figure 5C,D).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10813895	Notably, ER+ luminal cancer cell lines like T47D and MCF-7 express ELF5 and exhibit proliferation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "ER+", "luminal", "cancer",...
PMC11674146	Further, gene expression profiling has provided a quantitative molecular framework in the study of human lymphomas (Shao et al., 2024; Staudt & Dave, 2005).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3164356	55.	[ { "tags": [ "O", "O" ], "tokens": [ "55", "." ] } ]
PMC11545737	It has been proposed that progesterone plays a role in this clinical manifestation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "proposed", "that", "progesterone", "plays", "a", ...
PMC7802142	The significances among groups were analyzed using the Student’s t-test or One-way ANOVA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "significances", "among", "groups", "were", "analyzed", "using",...
PMC9473868	Of course, more research could be needed to confirm this, and this will be the focus of our future research.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "course...
PMC9429973	We registered 31 pregnancies in 11 female and 14 male patients (median age at ALL diagnosis 24 years; range 16-38).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11576293	RF and RM values were obtained for each ratio of organic modifier/water system (Supplementary Table S3), and a linear regression analysis was achieved to obtain the lipophilicity chromatographic descriptors (RMo, b, and Co, see Table 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11725127	C, D) Different concentrations of biotin–GA were incubated with USP2 at various times, followed by Western blot against Biotin–GA labeled USP2. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11283030	3Correlation between ACLY expression and immunoinhibitors in 534 ccRCC patients (TISIDB).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3Correlation", "between", "ACLY", "expression", "and", "immunoinhibitors", "in", ...
PMC9429973	Overall, dysregulated genes included tumor suppressors, protein kinases and phosphatases, cytokines and receptors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", ",", "dysregulated", "genes", "included", "t...
PMC11459296	Collectively, CB-MNCs demonstrate advantages over PB-MNCs in terms of reduced GvHD and sustained, balanced representation of myeloid–lymphoid immune cell subsets in primary and secondary hematopoietic organs, especially in NSGS mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9847912	The resulting variant was fully susceptible to GSK232 in the single-cycle assay (IC50 = 1.8 nM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resulting", "variant", "was", "...
PMC11684821	TRAJ42 was paired with 6 different TRAV genes within the cancer activated MR1-restricted T cell population (Figure 3C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TRAJ42", "was", "paired", ...
PMC11740573	In this study, we focused only on the determination of pro-inflammatory cytokines IL-6 and IL-1β due to their crucial importance in the pathogenesis of AV .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC6337547	Phenolic acids and their representative structures are shown in Table 1 and Figure 2, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Phenolic", "acids", "and", "their", "representative", ...
PMC9275501	Polymer-drug conjugates remain stable in the process of transport in the body.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Polymer-drug", "conjugates", "remain", "stable", "in", "the", "process", "of", "...
PMC9429973	Pts had substantially low BMD at BL which did not progress, and it is hypothesized that mitapivat may halt bone loss in pts with PK deficiency by decreasing hemolysis and ineffective erythropoiesis and stabilizing iron homeostasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6450504	This allows the protein to act as a ‘vacuum cleaner’ sweeping out drug molecules as they diffuse through the bilayers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "allo...
PMC9504875	cDNAs of RIG-I and RIG-I-2CARDs were cloned into a pCMV-3Tag-8 vector with a 3x FLAG tag at their C-termini (Stratagene, La Jolla, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	We identified two independent SNX9 knockout lines, while attempts to create SNX18 or SNX9 and SNX18 double knockout lines were unsuccessful (Supplementary Fig. S1g, h).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In patients, microbial diversity decreased after induction chemotherapy, but it recovered to a level similar to that of sibling controls after consolidation chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11656657	For the ERMS model, RD cell line was orthotopically inoculated in the right paw muscle of NSG mice.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "ERMS", "mo...
PMC11597291	The average hydrodynamic size and ζ-potential of the nCGO and nCGO-PEG particles are presented in Table 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "average", "hydrodynamic", "size", "and", ...
PMC9681981	Figure 3 represents the gel electrophoresis results of extracted RNA in the groups of exposed and nonexposed bacteria to Caco-2 cells, and no degraded RNA was detected in the gel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11528603	Binn.)	[ { "tags": [ "O", "O", "O" ], "tokens": [ "Binn", ".", ")" ] } ]
PMC8728081	TEM study was carried using a JEOL 2100 (JEOL, Japan) microscope operated at 200 kV. For the TEM sample preparation, suspension of particles was made similar to the DLS technique.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9672323	Two concentrations of piroxicam (3, and 30 µM) and dexamethasone (0.1, and 1 µM) were added to stimulated PBMCs alone or in co-culture with cell lines and incubated for 72 h at 37 °C, 5% CO2, and 95% humidity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6114978	PCR amplification was performed in technical triplicates on the Applied Biosystems QuantStudio 3 Real-Time PCR System (Applied Biosystems-Life Technologies).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCR", "amplification", ...
PMC5330095	Test compounds were serially diluted with DMEM plus 5% FBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Test", "compounds", "were", "serially", "diluted", "with", "DMEM", "plus", "5", "%", ...
PMC11794568	Transwell invasion assay was performed to assess the invasive ability of cutaneous melanoma cells with both CRIP1 and TFAM knocked down (scale bar 50 μm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11495567	However, CRAF/RAF1 phosphorylation decreased by 40%, suggesting significant changes in the KRAS/MAPK signaling patterns.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "CRAF/RAF1", "phosphorylation", "d...
PMC9250505	β-ACTIN was used as input control for cell lysate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β-ACTIN", "was", "used", "as", "input", "control", "for", "cell", "lysate", "." ] } ]
PMC11422150	Scores were recorded for each SCI mouse by three observers for the left and right hind limbs and averaged to get a single calculated value per mouse per test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767817	Subsequently, 50 µL of CellROX Deep Red (Thermo Fisher Scientific, USA) at a final concentration of 5 µM was added to each sample and incubated for 30 min at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8270637	When PD-1 on T cells recognizes and binds to PD-L1 on tumor cells, it will cause T cells to initiate the apoptosis mechanism, thereby allowing tumor cells to escape.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11412752	The amount of bacterial suspension added to the cell cultures was calculated from growth curves measured in the laboratory before.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "amount", "of", ...
PMC9847912	For the 293T/17 cells, the upper 200 μl of medium was removed from each well and discarded, and 100 μl of CellTiter-Glo Solution was added to each well.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9250505	The statistical change between treatment groups was analyzed using a one-way ANOVA followed by a Tukey’s multiple comparison test on endpoint xenograft volume.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11363012	To more easily visualize the differences in metabolite cell-type specificity across these five samples, we grouped the cell populations of each tissue into four clusters (using k-means clustering analysis) based on the peak area of the 20 natural products that could be structurally assigned with high confidence (Figures 6 and S22).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11684821	We previously demonstrated that mycobacterial infection or incubation with Ac-6-FP blocked target recognition by the MC.7.G5 TCR (18), and, in this study, Ac-6-FP blocked target recognition by MC.27.759S, K8T-1, and K8T-2 TCRs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748618	A recent genome-wide association study (GWAS) of HIV spVL with individuals of African ancestries identified a novel region on chromosome 1 that is significantly associated with decreased HIV spVL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9532503	WIL2-S cell suspension was added into the positive control, and the sample, target control, and target plus effector control were added to the respective wells of a 96-well plate and incubated with effector cells for 5 h. After incubation, the Bio-glow Luciferase reagent (Promega, USA) was added to the positive control, sample, and assay control wells followed by incubation for 5 to 10 min at 25 °C.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8557138	Another microfluidic model employing MDA-MB-231, HUVEC, macrovascular endothelial cells, and macrophages in an ECM matrix to demonstrate the role of macrophages in the process of intravasation was developed by Zervantonakis et al. The authors observed a ninefold increase in tumor cells undergoing intravasation when compared to control, guided by macrophage-derived TNF-α induced permeability of the endothelial barrier.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC8633974	Tests for RT activity in culture fluids showed that the RNP treated ACH2s upon stimulation did not produce progeny virus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tests", "for", "RT", "...
PMC10317042	As expected, both knockdown and overexpression of SOX10 reduced the drug efficacy of vorinostat on CCS cells due to the loss of SOX10-targeting effects (Fig. 5K and L).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The impact of COVID-19 was also reflected in a decline in pt care, as reported by HCPs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "impact", "of", "COVID-19", "was...
PMC6133382	Following Endo H digestion, the protein produced in the CHO-S cell line was largely unaltered, indicating that it possessed the normal complex, sialic acid–containing glycans.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8875242	Our experiments using digoxin (Table 2, Figure 2B) and RHD123 as probes confirmed this compound’s non-inhibition of ABCB1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "exper...
PMC11323699	TAX2-Cy5 concentration in tissues was compared to TSP-1 gene (THBS1) expression based on the Human Protein Atlas database, combining data from three transcriptomics datasets (HPA, GTEx, and FANTOM5) and using the internal normalization pipeline.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2944824	Luciferase activity was normalized to β-gal activity to correct for transfection efficiency.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Luciferase", "activity", "was", "normalized", "to", "β-gal", "activity", "to", "...
PMC9960565	The resulting solution was purified with dialysis (MW 2000 Da) in distilled water for 4.5 h and, after, was freeze-dried.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	S. J. Quinn, L. Anderson, L. Lohfeld, C. McShane Centre for Public Health, Queen’s University Belfast, Belfast; Aberdeen Centre for Health Data Science, University of Aberdeen, Aberdeen, United Kingdom Background: Haematological cancers are risk factors for severe COVID-19, and multiple myeloma (MM) patients may have further risk due to older age and susceptibility to infections.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	This will allow better characterization of SCD and development of Artificial Intelligence (AI) algorithms for personalized medicine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "will", "allow", "better",...
PMC11413393	Representative images from Day 5 (f) or Day 6 (g) are shown to the right.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "from", ...
PMC11420784	Therefore, any change in the levels of LC3-II can directly affect the efficiency and extent of autophagosome formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "any", "change",...
PMC11389534	Based on the protein structure and AI algorithm (e.g., Alphafold), , , we believe that more effective compounds targeting UFMylation will be generated in the future, and further clinical investigation is needed to investigate the viability and efficacy of these potential clinical applications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9917080	Other authors have shown that a decrease in the expression of the SELENOS gene under conditions of ER stress led to an increase in Tau protein phosphorylation and a decrease in cell viability .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The study used a web-based questionnaire to collect the QoL of children and the burden level of caregivers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "study", "used", "a", "web-based...
PMC11536589	The IC50 of MRTX1133 treated for 72 h in BxPC3 and MIA PaCa-2 cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O" ], "tokens": [ "The", "IC50", "of", "MRTX1133", "treated", ...
PMC7338939	C,D) Flow cytometry analysis showed the reduction of Notch1 expression after 96 h of treatment. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", ",", "D", ")", "Flow", ...
PMC7342409	GIST882-ir, 3.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "GIST882-ir", ",", "3", "." ] } ]
PMC9777812	Bta-miR-208b can regulated cell cycle and promotes skeletal muscle cell proliferation by targeting the CDKN1A gene .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bta-miR-208b", "can", "regulated", "cell", "cycle", "a...
PMC10006224	Hi-C experiments were performed with Arima-HiC Kit (#A510008) following manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hi-C", "experiments", "were", "performed", "with", "Arima-HiC", ...
PMC11673128	Neuroblastoma cell line was treated with lorlatinib at 1 µM; specifically, the lorlatinib-sensitive CLB-Ga cell line was excluded for in vitro analyses due to its high susceptibility to TKIs exposure.	[ { "tags": [ "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240448	For example, MEK is an important oncogenic driver in HCC1599 cells, and PKC is a significant driver in the MDA-MB-468 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], ...
PMC11786600	Contrarily, the PED2 and PED4 groups demonstrated enhanced therapeutic effects owing to the modulation of the PF-127 ratio in the dressings, thereby improving water vapor transmission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607321	Interestingly, other less obvious features that were highly ranked shed light on previously less explored biological mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "other", "less", ...
PMC5311252	Around 80% of vectors yielded stable clones.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Around", "80", "%", "of", "vectors", "yielded", "stable", "clones", "." ] } ]
PMC10006224	Cells were collected by trypsinization, counted and resuspended in RIPA buffer at 10 cells/ml for 30 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "collected", "by", "tr...
PMC9429973	M. Benetton, A. Da Ros, G. Borella, G. Longo, C. Tregnago, F. Locatelli, M. Pigazzi Department of Women’s and Children’s Health, Haematology-Oncology Clinic and Laboratory, University of Padova, Padova; Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesù and Sapienza University of Rome, Roma, Italy Background: Relapse still represents an unsolved problem for children with acute myeloid leukemia (AML), therefore more effective therapeutic strategies are needed for a complete blasts eradication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Intermediate risk cytogenetics were predominant in patients under 60 years old whereas Unfavourable karyotypes were more frequent in older patients.

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PMC11509278

The biosynthesis of steroid hormones is also closely related to changes in lipid metabolism and is also a therapeutic intervention point for the treatment of prostate cancer .

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PMC11640247

Scale bars, (B) 50 μm, (D) 100 μm. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "(", "B", ")", "50", "μm", ...

PMC8143558

However, it is also, in most cases unclear whether the saponin values shown in Table 1 are triterpenoid or steroid saponins as they are usually simply termed ‘saponins’ in the literature.

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PMC11806818

The characterization and detection of exosomes after separation helps to identify the morphology, quantity and level of exosome-specific molecular markers, which plays an important role in the early diagnosis, treatment and prognosis of diseases.

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PMC11711663

The other HNSCC sites, such as the oral cavity and oropharynx, are also affected by exposure to those carcinogens and their combination.

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PMC8740518

BCAAs can also donate nitrogen for glutamate synthesis, which can then be used to synthesize glutamine, important to tumor growth and maintenance (Hutson, Sweatt & LaNoue, 2005).

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PMC11240448

The prior network topology matrix is presented in Supplementary Table S5.

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PMC11300085

The results of cell proliferation showed that lower dose of chemerin (25 ng/mL) did not influence the cell growth at any time points, but higher concentrations of chemerin (50 and 100 ng/mL) significantly promoted the proliferation of SK-OV-3 cells after 48 h and 72 h incubation (P < 0.0001).

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PMC10877303

In this study, 2369 phytoconstituents were enlisted from Japanese medicinal plants, and these compounds were screened against 3C-like protease to identify feasible inhibitors.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC10968586

After 48 h treatment, 500 μM OLE increased the rate of apoptosis in A375 cells.

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PMC11725127

Recombinant USP2 was incubated with biotin or biotin–GA in the absence or presence of 75 μmol/L or 150 μmol/L of unlabeled GA.

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PMC9672323

Studies on indomethacin proved the positive effect of this medication on the proliferation of T cells prepared from patients with various types of cancers.

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PMC11423992

Jurkat, Clone E6-1 cell line was purchased from the National Collection of Authenticated Cell Cultures (CCRID cat. #

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PMC8753818

Activation of caspases in cancer cells may cause the loss of cell cycle checkpoints and increase the proliferation of these tumor cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activation", ...

PMC11754291

Spectral irradiance of 385 nm (LZ1-00UB0RU4) and 457 nm (LZ1-00B202) LEDs, measured at 12 cm from the spectrophotometer probe (OceanOptics, High-speed Spectrometers, SR2).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8557138

However, most of the existing 3D models employ established cell lines that may fail to simulate the in vivo tumoral response that have urged the development of 3D models employing parental tissue-derived cells.

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PMC11754094

We developed the ExCas-Analyzer for detecting CRISPR-induced DNA alterations without requiring a supercomputer and that can run on a personal computer.

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PMC11741906

A: Top twenty enriched GO terms in the biological process category.

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PMC9429973

Methods: Patients with PV who underwent abdominal computed tomography (CT) and who had palpable splenomegaly at diagnosis from January 1991 to December 2020 at Chungnam National University Hospital were enrolled in the study.

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PMC11707832

In an independent multi-ethnic cohort, they found that gene expression of MAN2B1 in peripheral monocytes showed a statistically significant association with a reduced upper-lower lobe ratio, whereas the gene expression of MAN1C1 was associated with an increased percentage of emphysema.

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PMC5415764

This approach could dramatically improve anticancer drug accumulation in tumor cells25.

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PMC7709199

This glycan plays a key role in the assembly of a crystallographic tetramer formed by the interaction of two Ig9 and two Ig7 domains (Fig. 1 ▸ b).

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PMC9621239

Shannon entropy (Sn) was used to quantify the complexity of HBV X QS.

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PMC10538569

To determine the phenotype of mDCs, monocyte-derived mDCs were incubated with PE-conjugated anti-CD83, CD86, DC-SIGN or HLA-DR antibodies for 45 min on ice.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC10812665

A reference library containing the collection of all amplification products was used for assigning read counts to each targeted gene.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "reference", "library", ...

PMC9436459

0.7 μg/mL (5-FU)Bel-7402n.a.

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "0.7", "μg/mL", "(5-FU)Bel-7402n.a", "." ] } ]

PMC9429973

Methods: We retrospectively reviewed the data of 23 patients who were diagnosed with COVID-19 and managed with ECMO.

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PMC11773391

A375 cells were treated with vMF (0.5 or 1 μM) and TMZ (2 mM) for 24 h either alone or in combination, and the number of apoptotic cells was detected by performing PI/Annexin V‐FITC staining (Figure 5C,D).

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PMC10813895

Notably, ER+ luminal cancer cell lines like T47D and MCF-7 express ELF5 and exhibit proliferation .

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PMC11674146

Further, gene expression profiling has provided a quantitative molecular framework in the study of human lymphomas (Shao et al., 2024; Staudt & Dave, 2005).

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PMC3164356

55.

[ { "tags": [ "O", "O" ], "tokens": [ "55", "." ] } ]

PMC11545737

It has been proposed that progesterone plays a role in this clinical manifestation.

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PMC7802142

The significances among groups were analyzed using the Student’s t-test or One-way ANOVA.

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PMC9473868

Of course, more research could be needed to confirm this, and this will be the focus of our future research.

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PMC9429973

We registered 31 pregnancies in 11 female and 14 male patients (median age at ALL diagnosis 24 years; range 16-38).

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PMC11576293

RF and RM values were obtained for each ratio of organic modifier/water system (Supplementary Table S3), and a linear regression analysis was achieved to obtain the lipophilicity chromatographic descriptors (RMo, b, and Co, see Table 6).

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PMC11725127

C, D) Different concentrations of biotin–GA were incubated with USP2 at various times, followed by Western blot against Biotin–GA labeled USP2. (

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PMC11283030

3Correlation between ACLY expression and immunoinhibitors in 534 ccRCC patients (TISIDB).

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PMC9429973

Overall, dysregulated genes included tumor suppressors, protein kinases and phosphatases, cytokines and receptors.

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PMC11459296

Collectively, CB-MNCs demonstrate advantages over PB-MNCs in terms of reduced GvHD and sustained, balanced representation of myeloid–lymphoid immune cell subsets in primary and secondary hematopoietic organs, especially in NSGS mice.

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PMC9847912

The resulting variant was fully susceptible to GSK232 in the single-cycle assay (IC50 = 1.8 nM).

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PMC11684821

TRAJ42 was paired with 6 different TRAV genes within the cancer activated MR1-restricted T cell population (Figure 3C).

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PMC11740573

In this study, we focused only on the determination of pro-inflammatory cytokines IL-6 and IL-1β due to their crucial importance in the pathogenesis of AV .

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PMC6337547

Phenolic acids and their representative structures are shown in Table 1 and Figure 2, respectively.

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PMC9275501

Polymer-drug conjugates remain stable in the process of transport in the body.

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PMC9429973

Pts had substantially low BMD at BL which did not progress, and it is hypothesized that mitapivat may halt bone loss in pts with PK deficiency by decreasing hemolysis and ineffective erythropoiesis and stabilizing iron homeostasis.

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PMC6450504

This allows the protein to act as a ‘vacuum cleaner’ sweeping out drug molecules as they diffuse through the bilayers.

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PMC9504875

cDNAs of RIG-I and RIG-I-2CARDs were cloned into a pCMV-3Tag-8 vector with a 3x FLAG tag at their C-termini (Stratagene, La Jolla, CA, USA).

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PMC11544122

We identified two independent SNX9 knockout lines, while attempts to create SNX18 or SNX9 and SNX18 double knockout lines were unsuccessful (Supplementary Fig. S1g, h).

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PMC9429973

In patients, microbial diversity decreased after induction chemotherapy, but it recovered to a level similar to that of sibling controls after consolidation chemotherapy.

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PMC11656657

For the ERMS model, RD cell line was orthotopically inoculated in the right paw muscle of NSG mice.

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PMC11597291

The average hydrodynamic size and ζ-potential of the nCGO and nCGO-PEG particles are presented in Table 2.

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PMC9681981

Figure 3 represents the gel electrophoresis results of extracted RNA in the groups of exposed and nonexposed bacteria to Caco-2 cells, and no degraded RNA was detected in the gel.

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PMC11528603

Binn.)

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PMC8728081

TEM study was carried using a JEOL 2100 (JEOL, Japan) microscope operated at 200 kV. For the TEM sample preparation, suspension of particles was made similar to the DLS technique.

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PMC9672323

Two concentrations of piroxicam (3, and 30 µM) and dexamethasone (0.1, and 1 µM) were added to stimulated PBMCs alone or in co-culture with cell lines and incubated for 72 h at 37 °C, 5% CO2, and 95% humidity.

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PMC6114978

PCR amplification was performed in technical triplicates on the Applied Biosystems QuantStudio 3 Real-Time PCR System (Applied Biosystems-Life Technologies).

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PMC5330095

Test compounds were serially diluted with DMEM plus 5% FBS.

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PMC11794568

Transwell invasion assay was performed to assess the invasive ability of cutaneous melanoma cells with both CRIP1 and TFAM knocked down (scale bar 50 μm).

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PMC11495567

However, CRAF/RAF1 phosphorylation decreased by 40%, suggesting significant changes in the KRAS/MAPK signaling patterns.

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PMC9250505

β-ACTIN was used as input control for cell lysate.

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PMC11422150

Scores were recorded for each SCI mouse by three observers for the left and right hind limbs and averaged to get a single calculated value per mouse per test.

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PMC11767817

Subsequently, 50 µL of CellROX Deep Red (Thermo Fisher Scientific, USA) at a final concentration of 5 µM was added to each sample and incubated for 30 min at 37 °C.

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PMC8270637

When PD-1 on T cells recognizes and binds to PD-L1 on tumor cells, it will cause T cells to initiate the apoptosis mechanism, thereby allowing tumor cells to escape.

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PMC11412752

The amount of bacterial suspension added to the cell cultures was calculated from growth curves measured in the laboratory before.

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PMC9847912

For the 293T/17 cells, the upper 200 μl of medium was removed from each well and discarded, and 100 μl of CellTiter-Glo Solution was added to each well.

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PMC9250505

The statistical change between treatment groups was analyzed using a one-way ANOVA followed by a Tukey’s multiple comparison test on endpoint xenograft volume.

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PMC11363012

To more easily visualize the differences in metabolite cell-type specificity across these five samples, we grouped the cell populations of each tissue into four clusters (using k-means clustering analysis) based on the peak area of the 20 natural products that could be structurally assigned with high confidence (Figures 6 and S22).

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PMC11684821

We previously demonstrated that mycobacterial infection or incubation with Ac-6-FP blocked target recognition by the MC.7.G5 TCR (18), and, in this study, Ac-6-FP blocked target recognition by MC.27.759S, K8T-1, and K8T-2 TCRs.

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PMC11748618

A recent genome-wide association study (GWAS) of HIV spVL with individuals of African ancestries identified a novel region on chromosome 1 that is significantly associated with decreased HIV spVL.

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PMC9532503

WIL2-S cell suspension was added into the positive control, and the sample, target control, and target plus effector control were added to the respective wells of a 96-well plate and incubated with effector cells for 5 h. After incubation, the Bio-glow Luciferase reagent (Promega, USA) was added to the positive control, sample, and assay control wells followed by incubation for 5 to 10 min at 25 °C.

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PMC8557138

Another microfluidic model employing MDA-MB-231, HUVEC, macrovascular endothelial cells, and macrophages in an ECM matrix to demonstrate the role of macrophages in the process of intravasation was developed by Zervantonakis et al. The authors observed a ninefold increase in tumor cells undergoing intravasation when compared to control, guided by macrophage-derived TNF-α induced permeability of the endothelial barrier.

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PMC8633974

Tests for RT activity in culture fluids showed that the RNP treated ACH2s upon stimulation did not produce progeny virus.

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PMC10317042

As expected, both knockdown and overexpression of SOX10 reduced the drug efficacy of vorinostat on CCS cells due to the loss of SOX10-targeting effects (Fig. 5K and L).

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PMC9429973

The impact of COVID-19 was also reflected in a decline in pt care, as reported by HCPs.

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PMC6133382

Following Endo H digestion, the protein produced in the CHO-S cell line was largely unaltered, indicating that it possessed the normal complex, sialic acid–containing glycans.

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PMC8875242

Our experiments using digoxin (Table 2, Figure 2B) and RHD123 as probes confirmed this compound’s non-inhibition of ABCB1.

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PMC11323699

TAX2-Cy5 concentration in tissues was compared to TSP-1 gene (THBS1) expression based on the Human Protein Atlas database, combining data from three transcriptomics datasets (HPA, GTEx, and FANTOM5) and using the internal normalization pipeline.

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PMC2944824

Luciferase activity was normalized to β-gal activity to correct for transfection efficiency.

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PMC9960565

The resulting solution was purified with dialysis (MW 2000 Da) in distilled water for 4.5 h and, after, was freeze-dried.

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PMC9429973

S. J. Quinn, L. Anderson, L. Lohfeld, C. McShane Centre for Public Health, Queen’s University Belfast, Belfast; Aberdeen Centre for Health Data Science, University of Aberdeen, Aberdeen, United Kingdom Background: Haematological cancers are risk factors for severe COVID-19, and multiple myeloma (MM) patients may have further risk due to older age and susceptibility to infections.

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PMC9429973

This will allow better characterization of SCD and development of Artificial Intelligence (AI) algorithms for personalized medicine.

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PMC11413393

Representative images from Day 5 (f) or Day 6 (g) are shown to the right.

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PMC11420784

Therefore, any change in the levels of LC3-II can directly affect the efficiency and extent of autophagosome formation.

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PMC11389534

Based on the protein structure and AI algorithm (e.g., Alphafold), , , we believe that more effective compounds targeting UFMylation will be generated in the future, and further clinical investigation is needed to investigate the viability and efficacy of these potential clinical applications.

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PMC9917080

Other authors have shown that a decrease in the expression of the SELENOS gene under conditions of ER stress led to an increase in Tau protein phosphorylation and a decrease in cell viability .

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PMC9429973

The study used a web-based questionnaire to collect the QoL of children and the burden level of caregivers.

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PMC11536589

The IC50 of MRTX1133 treated for 72 h in BxPC3 and MIA PaCa-2 cells. (

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PMC7338939

C,D) Flow cytometry analysis showed the reduction of Notch1 expression after 96 h of treatment. (

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PMC7342409

GIST882-ir, 3.

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PMC9777812

Bta-miR-208b can regulated cell cycle and promotes skeletal muscle cell proliferation by targeting the CDKN1A gene .

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PMC10006224

Hi-C experiments were performed with Arima-HiC Kit (#A510008) following manufacturer’s instructions.

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PMC11673128

Neuroblastoma cell line was treated with lorlatinib at 1 µM; specifically, the lorlatinib-sensitive CLB-Ga cell line was excluded for in vitro analyses due to its high susceptibility to TKIs exposure.

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PMC11240448

For example, MEK is an important oncogenic driver in HCC1599 cells, and PKC is a significant driver in the MDA-MB-468 cell line.

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PMC11786600

Contrarily, the PED2 and PED4 groups demonstrated enhanced therapeutic effects owing to the modulation of the PF-127 ratio in the dressings, thereby improving water vapor transmission.

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PMC11607321

Interestingly, other less obvious features that were highly ranked shed light on previously less explored biological mechanisms.

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PMC5311252

Around 80% of vectors yielded stable clones.

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PMC10006224

Cells were collected by trypsinization, counted and resuspended in RIPA buffer at 10 cells/ml for 30 min.

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PMC9429973

M. Benetton, A. Da Ros, G. Borella, G. Longo, C. Tregnago, F. Locatelli, M. Pigazzi Department of Women’s and Children’s Health, Haematology-Oncology Clinic and Laboratory, University of Padova, Padova; Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesù and Sapienza University of Rome, Roma, Italy Background: Relapse still represents an unsolved problem for children with acute myeloid leukemia (AML), therefore more effective therapeutic strategies are needed for a complete blasts eradication.

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