OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11537649	Illustration of the predictive binding site between miR-152-3p and CDK6. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Illustration", "of", "the", "predictive", "binding", "site", "between", "mi...
PMC11592008	Western blotting can be used to visualize proteolytic cleavage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blotting", "can", "be", "used", "to", "visualize", "proteolytic", "cleavage", "." ] } ]
PMC9429973	Cyclosporine, mycophenolate mofetil and short-term methotrexate were employed for GVHD prophylaxis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cyclosporine", ",", "mycophenolate", "mofetil", "and", "short-term", "methotrexate", "...
PMC11521786	Although HER3 expression has been observed in various nonmalignant tissues, similar to other members of the EGFR family (HER1 and HER2), which have different approved treatments for different types of cancer, early clinical trials with agents targeting HER3 have shown a favorable toxicity profile (1), indicating the safety of these HER3 treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878278	After 24 h of incubation, half of the media was removed and replenished with fresh media.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "24", "h", "of", "incubation", ",",...
PMC11683240	Subsequently, the experiment was performed as described in (B and C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "the", "experiment", "was", "performed", "as", ...
PMC11172027	Jurkat-J6 and MTC-SK were used for cell culture and further experiments.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Jurkat-J6", "and", "MTC-SK", "were", "used", "for", "cell", "culture", "a...
PMC11222184	While Debio0932 showed no notable impact on APAF1 and CASP2 expression, it elicited a decrease in CASP9 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "Debio0932", "showed", "n...
PMC11697065	Peptides were separated using buffer A (0.1 % FA) and buffer B (80 % MeCN, 0.1 % FA) at a flow rate of 300 nl/min and column temperature of 40°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8524093	CHIKV-specific Ab response reaches its plateau around 21 dpi, and second burst of memory B-cell proliferation occurs only at 28 dpi (Messaoudi et al., 2013).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11266100	However, firstly the efficiency of permeabilization to (YP) following PEF was characterized and compared with CHO-K1 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "However", ",",...
PMC11754784	Then cells were washed with DPBS three times and incubated with B6H12-PE at 4 °C for 30 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", "cells", "were", "washed",...
PMC10006224	For each map, the cell cycle profile according to DNA content appears on top while the distribution of antibody intensities is plotted on the right.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11746942	p < 0.05, p < 0.01, *p < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", ",", "", "", "p", "<", ...
PMC11656657	GD2 expression was detected in approximately 55% of the primary sarcoma tumors and it is positively modulated by EZH2 inhibitor Tazemetostat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GD2", "expre...
PMC11502443	p < 0.05 by unpaired Student’s t-test comparing the log (τ/KA) of the same peptide at the WT and E354Q GIP receptors for each signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The clinical picture is dominated by bone manifestations, anemic syndrome (81%) and renal failure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "clinical", "picture", "is", "do...
PMC11777207	For systemic administration of antibodies, anti–PD-1 (Selleckchem clones RMP1-14 and 29F.1A12), IgG isotype control (clone LTF-2), and PD-L1 antibodies including the 43H12 clone (a gift from Y. Zhu) and 10F9.G2 (BioXCell) were injected intraperitoneally in a final volume of 200 μl of PBS at a concentration of 200 μg/ml.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11564322	It has been demonstrated that increased expression of neutrophil elastase protein and cDNA results in migration of HL-60 cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "It", "has", "been", "dem...
PMC11680982	ET: endocrine therapy, CDK4/6i CDK4/6 inhibitor, Ner Neratinib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ET", ":", "endocrine", "therapy", ",", "CDK4/6i", "CDK4/6", "inhibitor", ",", "Ner", ...
PMC11746942	Proteins (10–20 μg) were separated by 10% SDS‒PAGE and transferred to a PVDF membrane, which was subsequently blocked in 5% bovine serum albumin (BSA) for 1 h at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6487404	Moreover, when compared with REG alone, P-gp inhibitors did not significantly improve the apical to basolateral absorption of REG in Caco-2 monolayers (Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...
PMC11607321	c–e, similar to b, using MOFA, MOVE and mean imputed values, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "–", "e", ",", "similar", "t...
PMC11534377	Also, the graphical representation of body weight changes across the treatment span, indicating the systemic impact of the treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", ",", "the"...
PMC9429973	Four additional pts received V1 and V2 in CLL2-BAG.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Four", "additional", "pts", "received", "V1", "and", "V2", "in", "CLL2-BAG", "." ] } ]
PMC10936243	Many veterinarians revealed that they held more than one role within the practice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Many", "veterinarians", "revealed", "that", "they", "held", "more", "than",...
PMC11420784	Scale bar, 5 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "5", "μm", "." ] } ]
PMC9429973	History, clinical data and laboratory and imaging investigations were brought from patients’ files.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "History", ",", "clinical", "data", "and", "laboratory", "an...
PMC11657695	Identification of the Kv1.2 channels as molecular targets accounting for the effects in the control of cell proliferation, a pivotal process in tumor expansion, opens up the way to consider the use of inhibitors of these channels in cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11347429	Gene expression levels of genes with a cis-eQTL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gene", "expression", "levels", "of", "genes", "with", "a", "cis-eQTL", "." ] } ]
PMC11578343	HMECs were grown at 37 °C in M87A medium supplemented with cholera toxin and oxytocin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HMECs", "were", "grown", "at", "37", "°", "C", ...
PMC11348300	While traditionally, the use of ALA-PpIX for surgical guidance has been confined to areas with low background PpIX production in normal tissues, such as the brain and bladder, PRESTO introduces an innovative approach to extend the utility of PpIX for FGS to potentially any type of solid tumor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878562	Representative data from one experiment shown in A (n= 4-5). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "data", "from", "one", "experiment", "shown", ...
PMC11738017	The TCE cytotoxicity assay dose-response curve.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "TCE", "cytotoxicity", "assay", "dose-response", "curve", "." ] } ]
PMC11535726	Amongst the two asexual morphs that have been described so far, only the dendryphiopsis-like morph is linked to the sexual morph, while the sporidesmium-like state has not been associated with the sexual morph (Hawksworth 1985; Wang et al. 2004; Mulenko et al. 2008; Boonmee et al. 2012; Su et al. 2016; Sun et al. 2021; Xu et al.2023; de Farias et al. 2024).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11471176	Carboxyfluorescein succinimidyl ester (CFSE, C34554, Sigma-Aldrich, Saint Louis, MO, USA) was used to label MDA-MB-231 and MCF-7 cells before the experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "...
PMC4485648	Protein concentrations were determined by bicinchoninic acid assay (Pierce Biotechnology, Rockford, IL, USA) according to the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC6461034	Cool the tube on ice.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cool", "the", "tube", "on", "ice", "." ] } ]
PMC9429973	The primary endpoint for Part 1 is the frequency of dose-limiting toxicities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", "endpoint", "for", "Part", "1", "is", "the", "frequency", ...
PMC9841531	Thus, we applied an MTT-based efficacy assay as reported earlier.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "we", "applied", "an", "MTT-based", "efficacy", "assay", "as", "reported"...
PMC10778532	ZHX2 drives proliferation, migration, colony formation and invasion via activating multiple proteins including Twist, Snail, VEGF, MEK, ERK 1/2 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9727330	The Ser/Thr kinase Raf protein (c-Raf-1, Raf-B, or Raf-A) activates the downstream kinase MEK1 and MEK2, which, in turn, phosphorylate Ser/Thr kinases ERK1 and its homolog ERK2 (Shaul and Seger, 2007; Elimam et al., 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730000	The cells were then allowed to undergo lysis at 4 °C in the dark.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "then", "allowed", "to", "undergo", ...
PMC10142392	Consequently, "worm-like" structures exhibit a drug loading twice that of spherical NPs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "\"", "worm-like", "\"", "structures", ...
PMC3164356	The CHO-K1 genome and transcriptome provide insights pertaining to these entry receptors and HSV infection (Fig. 4b).	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CHO-K1", "genome", ...
PMC9611901	We considered HepG2 cells a suitable test system because they retain—to a certain extent—the activity of metabolic enzymes that are important for the biotransformation of chemicals in the liver, and exhibit many of the genotypic and phenotypic characteristics of liver cells .	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9841531	Energy minimization was accomplished with the Universal Force Field (UFF) within the PyRx.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Energy", "minimization", "was", "accomplished", "with", "the", ...
PMC11756907	Reduced graphene oxide flakes were obtained in a mould with sizes ranging from 2 nm to 6 μm, which were later cleaned in a vacuum filtration system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8427838	In an additional strategy to probe the effect of TMIGD1 in filopodia protrusions, we expressed TMIGD1 in a colorectal carcinoma cell line, RKO cells and examined filopodia structures via phalloidin staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC8973725	The percentage of positive tumor cells and the staining intensity were then multiplied to generate the immunoreactivity score (IS) for each tumor sample.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11675244	For example, in lung physiological development, the inhibition of the Wnt/β-catenin pathway impacts the differentiation of proximal stem cells into airway epithelial cells, while its activation results in distal epithelial cell specialization .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731614	Cultured keratinocytes from the RD and HFD mice were grown to 90% confluency in low-calcium, EV-depleted medium for scratch assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cultured", "...
PMC11442172	PDAC cells cultured in TIFM more closely resembled the metabolic state of PDAC tumors compared to standard cell culture models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PDAC", "cells", "cultured", ...
PMC8584319	Concentrations of SP600125 that used in this experiment were sufficient to inhibit the JNK downstream factor c-Jun and had no effect on the phosphorylation of ERK1/2 and p38 (Figure 5c, right).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10758402	= not significant.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "=", "not", "significant", "." ] } ]
PMC11345828	F, G. Treatment of NCI-H929-derived xenograft models with 26 showed significant induction of Caspase 3/7 activity and disruption of Mcl-1:BIM complexes with a maximum at 6 h after treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11045125	Survival data were analyzed by Kruskal-Wallis method using program M-Stat 7.0 (University of Wisconsin).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Survival", "data", "were", "analyzed", "by", "Kruskal-...
PMC11525028	Quantification of lung metastasis in the mouse model (n = 8 per group). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "of", "lung", "metastasis", "in", "th...
PMC6803987	IV.7.2 (0.2 g) were separated and purified by HPLC, and the compound, esculetin (23.0 mg, tR = 15.479 min) was separated (10% ~ 100% MeOH-H2O, 1 mL/min) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11564405	T cell subtypes have demonstrated prognostic value in cancer patients and served as indicators of immunotherapy effectiveness .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "T", "cell", "subtypes", "have", "demonstrated", ...
PMC11792090	Another concern lies in the potential safety issues in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Another", "concern", "lies", "in", "the", "potential", "safety", "issues", "in", "vivo", "...
PMC9646302	In addition, LAPTM5 inhibits tumor invasion, clonogenicity, and tumorigenicity by inhibiting NF-κB activation, which may act as a therapeutic target for CD40+gliomas .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11638255	A portion of the conditioned media was collected as pre-incubation control, designated as: - neutrophil.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "portion", "of", "the", "conditioned", ...
PMC11694625	Characteristic signals for the quinoline ring are multiple peaks at 9.00–7.60 ppm in H NMR spectra.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Characteristic", "signals", "for", "the", "quinoline", ...
PMC9429973	Common TEAEs (≥ 15% all grades) were hyperuricemia (38.6%), hypertriglyceridemia and anemia (each 36.4%), thrombocytopenia (29.5%), hyperphosphatemia (27.3%), neutropenia (25%), proteinuria (22.7%), leukopenia (18.2%), and diarrhea (15.9%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11737091	To further confirm that DBF4 is involved in cell cycle control in ccRCC, the ccRCC cell lines 786-O and A498, which highly express DBF4, were selected for further investigation of the pro-oncogenic function of DBF4 in ccRCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "...
PMC11545868	They also inactivate the anti-apoptotic proteins Bcl-2 and Bcl-xL. After that, MOMP releases pro-apoptotic proteins from the mitochondria into the cytoplasm, including cytochrome c. Cytochrome c forms an apoptotic complex with other proteins that activates the initiator caspase-9.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11530949	Cells were cultured with Ephedra intermedia extricates and the Ag-doped CuO NPs (3.125, 6.25, 12.5, 25, 50 µg/ml) and incubated at 37°C and 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In a single visit, the informed consent form was signed and the patient’s clinical data were recorded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "a", "single", "visit", ...
PMC9429973	It is involved in the regulation of the cell cycle by destroying Cdk4/Cdk6 complexes with cyclins D, blocking the transition of the cell from G1 to S phase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Comparing maintenance vs alloSCT we observe no differences in the Intermediate ELN2017 group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Comparing", "maintenance", "vs", "alloSCT", "we", "observe", "no", "differe...
PMC11300639	We constructed an RNF26 T348A (threonine to alanine) mutant to mimic the dephosphorylation of RNF26 at the T348 site (Fig. 2l).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC6892818	Bars show mean GM-CSF concentration (pg/ml) ± SEM for two technical replicates and are typical of two independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bars", "show", "m...
PMC11506670	The results for NRAS G48C and E37K, but not for Q43K, are congruent with both in vitro and in vivo studies, showing that while KRAS mutations do not have pro-survival effects, NRAS mutants do .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11552389	To assess the baseline proliferation of the cells, live cell time-lapse imaging was employed, enabling accurate evaluation of cell proliferation dynamics (zenCELL Owl).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11402217	143B cells at 70–80% confluence in 12-well plates were treated with 0.1 μM–1.0 μM XD23 at 37°C for 48 h. Post pancreatin digestion and PBS wash, cells were fixed in 50% ethanol and stained with propidium iodide solution (Sigma, US).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8345486	The reference nido-carborane derivative (no metal ions) and unmodified nucleosides were not as effective.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reference", "nido-carborane", "derivative", "(", ...
PMC11320834	We found two uncertain significance variants (VUS) throughout all samples (Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "found", "two", "uncertain", "significance", "var...
PMC11525028	Protein level of ASNS in ATF4-KD 143B (left) and HOS (right) cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "level", "of", "ASNS", ...
PMC11655536	F, G Western Blot detect the expression of LAMP1 of RPMI-8226 (F) and U266 (G) treated HA at 10 μM for 48 h and statistical analysis of LAMP1 expression, normalized by tubulin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10329237	This technique is based on the dismutation of this radical by SOD and the competition between the pyrogallol autoxidation by O2•¯. A unit of Cu, Zn-SOD activity is determined as the quantity of enzyme needed for causing 50% inhibition of pyrogallol autoxidation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11088135	Long non-coding RNAs (lncRNAs) are greater than 200 nucleotides in length and do not encode proteins .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Long", "non-coding", "RNAs", "(", "lnc...
PMC9429973	Associations between baseline sBCMA levels and baseline patient characteristics or response to treatment were evaluated using an unpaired 2-sample Wilcoxon test (significance level: p≤0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11568601	The identified DEGs included HSPA5 (encoding BiP) and ERN1 (encoding the IRE1 protein), as well as apoptosis-associated gene DDIT3 (encoding the CHOP protein).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11699178	Cell experiments were conducted in triplicate. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "experiments", "were", "conducted", "in", "triplicate", ".", "*" ] } ]
PMC9325715	The comparison between cytotoxicity of Fe-bLTF with iron citrate was performed at the same iron concentration in mM (determined by ICP-MS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11802929	PBMCs from 62 participants were thawed for CD8 T cell enrichment (Human CD8 T cell Isolation Kit, Miltenyi Biotec) according to the manufacturer’s protocol then incubated with Human TruStain FcX blocking reagent (422302, BioLegend) for 10 min at 4 °C before wash.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7351993	First, to reduce the local stress concentration in the bonding process, we formed a grating pattern on the borosilicate glass surface of the base and cover layers by using the dry etching technique.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7504302	The invention of a series of rapidly evolving large-scale genomic and transcriptomic sequencing technologies facilitated the detection and identification of novel mutations and gene expression deregulations in cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11052306	Of interest are also more “inorganic” dendrimers, in particular, those having either phosphorus or silicon at each branching point, which were reviewed early and more recently .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We are also encouraged to see a significant increase in the number of single unit transfusions, in line with NICE Guidance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "are", ...
PMC11489351	Scale bars represent 20 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", "represent", "20", "μm", "." ] } ]
PMC11683240	α1AT is represented in gray carton and pertussis toxin in colored surfaces, S1, green; S2, turquoise; S3, purple; S4, red; S5, yellow.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11621493	Image data were acquired in z-stacks with a resolution of 1,024 × 1,024 pixels with a scan speed of 600 Hz in unidirectional scan mode.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	The patients at risk were classified by ThroLy score (>1), by Khorana score (≥2), and Vienna CATS score (expressed as predicted 6 months risk for venous TE (VTE) development).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11574029	Proteins encoded by Notch genes act as transmembrane receptors involved in various biological processes, including cell fate determination, embryonic development, organ formation, and tissue repair .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10125312	Further details on synthesis, surface modification, and optical measurements are described in the Supporting Information (SI).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "details", "on", ...
PMC11470999	In vitro anti‐melanoma efficacies of PF‐Biotin in B16 and A375 cells indicated that the inclusion of biotin did not significantly affect PF's inhibitory activities against melanoma (Figures 1B and 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11706776	It can be hypothesized that the association between patient survival and KCNN1 expression, demonstrated in two independent cohorts of patients, is closely linked to the ability of KCNN1 to modulate the cellular response to chemotherapy, this process being strongly associated with patient survival .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11413393	RNA was then extracted from both the cytoplasmic and nuclear fractions using the Qiagen RNeasy mini kit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "was", "then", "extracted", "from", "...

PMC11537649

Illustration of the predictive binding site between miR-152-3p and CDK6. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Illustration", "of", "the", "predictive", "binding", "site", "between", "mi...

PMC11592008

Western blotting can be used to visualize proteolytic cleavage.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blotting", "can", "be", "used", "to", "visualize", "proteolytic", "cleavage", "." ] } ]

PMC9429973

Cyclosporine, mycophenolate mofetil and short-term methotrexate were employed for GVHD prophylaxis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cyclosporine", ",", "mycophenolate", "mofetil", "and", "short-term", "methotrexate", "...

PMC11521786

Although HER3 expression has been observed in various nonmalignant tissues, similar to other members of the EGFR family (HER1 and HER2), which have different approved treatments for different types of cancer, early clinical trials with agents targeting HER3 have shown a favorable toxicity profile (1), indicating the safety of these HER3 treatments.

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PMC9878278

After 24 h of incubation, half of the media was removed and replenished with fresh media.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "24", "h", "of", "incubation", ",",...

PMC11683240

Subsequently, the experiment was performed as described in (B and C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "the", "experiment", "was", "performed", "as", ...

PMC11172027

Jurkat-J6 and MTC-SK were used for cell culture and further experiments.

[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Jurkat-J6", "and", "MTC-SK", "were", "used", "for", "cell", "culture", "a...

PMC11222184

While Debio0932 showed no notable impact on APAF1 and CASP2 expression, it elicited a decrease in CASP9 expression.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "Debio0932", "showed", "n...

PMC11697065

Peptides were separated using buffer A (0.1 % FA) and buffer B (80 % MeCN, 0.1 % FA) at a flow rate of 300 nl/min and column temperature of 40°C.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8524093

CHIKV-specific Ab response reaches its plateau around 21 dpi, and second burst of memory B-cell proliferation occurs only at 28 dpi (Messaoudi et al., 2013).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11266100

However, firstly the efficiency of permeabilization to (YP) following PEF was characterized and compared with CHO-K1 cell line.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "However", ",",...

PMC11754784

Then cells were washed with DPBS three times and incubated with B6H12-PE at 4 °C for 30 min.

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PMC10006224

For each map, the cell cycle profile according to DNA content appears on top while the distribution of antibody intensities is plotted on the right.

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PMC11746942

p < 0.05, **p < 0.01, ***p < 0.001.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", ",", "*", "*", "p", "<", ...

PMC11656657

GD2 expression was detected in approximately 55% of the primary sarcoma tumors and it is positively modulated by EZH2 inhibitor Tazemetostat.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GD2", "expre...

PMC11502443

p < 0.05 by unpaired Student’s t-test comparing the log (τ/KA) of the same peptide at the WT and E354Q GIP receptors for each signaling pathway.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The clinical picture is dominated by bone manifestations, anemic syndrome (81%) and renal failure.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "clinical", "picture", "is", "do...

PMC11777207

For systemic administration of antibodies, anti–PD-1 (Selleckchem clones RMP1-14 and 29F.1A12), IgG isotype control (clone LTF-2), and PD-L1 antibodies including the 43H12 clone (a gift from Y. Zhu) and 10F9.G2 (BioXCell) were injected intraperitoneally in a final volume of 200 μl of PBS at a concentration of 200 μg/ml.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11564322

It has been demonstrated that increased expression of neutrophil elastase protein and cDNA results in migration of HL-60 cells .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "It", "has", "been", "dem...

PMC11680982

ET: endocrine therapy, CDK4/6i CDK4/6 inhibitor, Ner Neratinib.

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PMC11746942

Proteins (10–20 μg) were separated by 10% SDS‒PAGE and transferred to a PVDF membrane, which was subsequently blocked in 5% bovine serum albumin (BSA) for 1 h at room temperature.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6487404

Moreover, when compared with REG alone, P-gp inhibitors did not significantly improve the apical to basolateral absorption of REG in Caco-2 monolayers (Table 2).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...

PMC11607321

c–e, similar to b, using MOFA, MOVE and mean imputed values, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "–", "e", ",", "similar", "t...

PMC11534377

Also, the graphical representation of body weight changes across the treatment span, indicating the systemic impact of the treatments.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", ",", "the"...

PMC9429973

Four additional pts received V1 and V2 in CLL2-BAG.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Four", "additional", "pts", "received", "V1", "and", "V2", "in", "CLL2-BAG", "." ] } ]

PMC10936243

Many veterinarians revealed that they held more than one role within the practice.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Many", "veterinarians", "revealed", "that", "they", "held", "more", "than",...

PMC11420784

Scale bar, 5 μm.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "5", "μm", "." ] } ]

PMC9429973

History, clinical data and laboratory and imaging investigations were brought from patients’ files.

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PMC11657695

Identification of the Kv1.2 channels as molecular targets accounting for the effects in the control of cell proliferation, a pivotal process in tumor expansion, opens up the way to consider the use of inhibitors of these channels in cancer.

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PMC11347429

Gene expression levels of genes with a cis-eQTL.

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PMC11578343

HMECs were grown at 37 °C in M87A medium supplemented with cholera toxin and oxytocin.

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PMC11348300

While traditionally, the use of ALA-PpIX for surgical guidance has been confined to areas with low background PpIX production in normal tissues, such as the brain and bladder, PRESTO introduces an innovative approach to extend the utility of PpIX for FGS to potentially any type of solid tumor.

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PMC9878562

Representative data from one experiment shown in A (n= 4-5). (

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PMC11738017

The TCE cytotoxicity assay dose-response curve.

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PMC11535726

Amongst the two asexual morphs that have been described so far, only the dendryphiopsis-like morph is linked to the sexual morph, while the sporidesmium-like state has not been associated with the sexual morph (Hawksworth 1985; Wang et al. 2004; Mulenko et al. 2008; Boonmee et al. 2012; Su et al. 2016; Sun et al. 2021; Xu et al.2023; de Farias et al. 2024).

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PMC11471176

Carboxyfluorescein succinimidyl ester (CFSE, C34554, Sigma-Aldrich, Saint Louis, MO, USA) was used to label MDA-MB-231 and MCF-7 cells before the experiment.

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PMC4485648

Protein concentrations were determined by bicinchoninic acid assay (Pierce Biotechnology, Rockford, IL, USA) according to the manufacturer’s instructions.

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PMC6461034

Cool the tube on ice.

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PMC9429973

The primary endpoint for Part 1 is the frequency of dose-limiting toxicities.

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PMC9841531

Thus, we applied an MTT-based efficacy assay as reported earlier.

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PMC10778532

ZHX2 drives proliferation, migration, colony formation and invasion via activating multiple proteins including Twist, Snail, VEGF, MEK, ERK 1/2 .

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PMC9727330

The Ser/Thr kinase Raf protein (c-Raf-1, Raf-B, or Raf-A) activates the downstream kinase MEK1 and MEK2, which, in turn, phosphorylate Ser/Thr kinases ERK1 and its homolog ERK2 (Shaul and Seger, 2007; Elimam et al., 2020).

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PMC11730000

The cells were then allowed to undergo lysis at 4 °C in the dark.

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PMC10142392

Consequently, "worm-like" structures exhibit a drug loading twice that of spherical NPs.

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PMC3164356

The CHO-K1 genome and transcriptome provide insights pertaining to these entry receptors and HSV infection (Fig. 4b).

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PMC9611901

We considered HepG2 cells a suitable test system because they retain—to a certain extent—the activity of metabolic enzymes that are important for the biotransformation of chemicals in the liver, and exhibit many of the genotypic and phenotypic characteristics of liver cells .

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PMC9841531

Energy minimization was accomplished with the Universal Force Field (UFF) within the PyRx.

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PMC11756907

Reduced graphene oxide flakes were obtained in a mould with sizes ranging from 2 nm to 6 μm, which were later cleaned in a vacuum filtration system.

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PMC8427838

In an additional strategy to probe the effect of TMIGD1 in filopodia protrusions, we expressed TMIGD1 in a colorectal carcinoma cell line, RKO cells and examined filopodia structures via phalloidin staining.

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PMC8973725

The percentage of positive tumor cells and the staining intensity were then multiplied to generate the immunoreactivity score (IS) for each tumor sample.

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PMC11675244

For example, in lung physiological development, the inhibition of the Wnt/β-catenin pathway impacts the differentiation of proximal stem cells into airway epithelial cells, while its activation results in distal epithelial cell specialization .

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PMC11731614

Cultured keratinocytes from the RD and HFD mice were grown to 90% confluency in low-calcium, EV-depleted medium for scratch assays.

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PMC11442172

PDAC cells cultured in TIFM more closely resembled the metabolic state of PDAC tumors compared to standard cell culture models.

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PMC8584319

Concentrations of SP600125 that used in this experiment were sufficient to inhibit the JNK downstream factor c-Jun and had no effect on the phosphorylation of ERK1/2 and p38 (Figure 5c, right).

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PMC10758402

= not significant.

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PMC11345828

F, G. Treatment of NCI-H929-derived xenograft models with 26 showed significant induction of Caspase 3/7 activity and disruption of Mcl-1:BIM complexes with a maximum at 6 h after treatment.

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PMC11045125

Survival data were analyzed by Kruskal-Wallis method using program M-Stat 7.0 (University of Wisconsin).

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PMC11525028

Quantification of lung metastasis in the mouse model (n = 8 per group). (

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PMC6803987

IV.7.2 (0.2 g) were separated and purified by HPLC, and the compound, esculetin (23.0 mg, tR = 15.479 min) was separated (10% ~ 100% MeOH-H2O, 1 mL/min) .

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PMC11564405

T cell subtypes have demonstrated prognostic value in cancer patients and served as indicators of immunotherapy effectiveness .

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PMC11792090

Another concern lies in the potential safety issues in vivo.

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PMC9646302

In addition, LAPTM5 inhibits tumor invasion, clonogenicity, and tumorigenicity by inhibiting NF-κB activation, which may act as a therapeutic target for CD40+gliomas .

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PMC11638255

A portion of the conditioned media was collected as pre-incubation control, designated as: - neutrophil.

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PMC11694625

Characteristic signals for the quinoline ring are multiple peaks at 9.00–7.60 ppm in H NMR spectra.

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PMC9429973

Common TEAEs (≥ 15% all grades) were hyperuricemia (38.6%), hypertriglyceridemia and anemia (each 36.4%), thrombocytopenia (29.5%), hyperphosphatemia (27.3%), neutropenia (25%), proteinuria (22.7%), leukopenia (18.2%), and diarrhea (15.9%).

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PMC11737091

To further confirm that DBF4 is involved in cell cycle control in ccRCC, the ccRCC cell lines 786-O and A498, which highly express DBF4, were selected for further investigation of the pro-oncogenic function of DBF4 in ccRCC.

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PMC11545868

They also inactivate the anti-apoptotic proteins Bcl-2 and Bcl-xL. After that, MOMP releases pro-apoptotic proteins from the mitochondria into the cytoplasm, including cytochrome c. Cytochrome c forms an apoptotic complex with other proteins that activates the initiator caspase-9.

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PMC11530949

Cells were cultured with Ephedra intermedia extricates and the Ag-doped CuO NPs (3.125, 6.25, 12.5, 25, 50 µg/ml) and incubated at 37°C and 5% CO2.

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PMC9429973

In a single visit, the informed consent form was signed and the patient’s clinical data were recorded.

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PMC9429973

It is involved in the regulation of the cell cycle by destroying Cdk4/Cdk6 complexes with cyclins D, blocking the transition of the cell from G1 to S phase.

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PMC9429973

Comparing maintenance vs alloSCT we observe no differences in the Intermediate ELN2017 group.

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PMC11300639

We constructed an RNF26 T348A (threonine to alanine) mutant to mimic the dephosphorylation of RNF26 at the T348 site (Fig. 2l).

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PMC6892818

Bars show mean GM-CSF concentration (pg/ml) ± SEM for two technical replicates and are typical of two independent experiments.

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PMC11506670

The results for NRAS G48C and E37K, but not for Q43K, are congruent with both in vitro and in vivo studies, showing that while KRAS mutations do not have pro-survival effects, NRAS mutants do .

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PMC11552389

To assess the baseline proliferation of the cells, live cell time-lapse imaging was employed, enabling accurate evaluation of cell proliferation dynamics (zenCELL Owl).

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PMC11402217

143B cells at 70–80% confluence in 12-well plates were treated with 0.1 μM–1.0 μM XD23 at 37°C for 48 h. Post pancreatin digestion and PBS wash, cells were fixed in 50% ethanol and stained with propidium iodide solution (Sigma, US).

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PMC8345486

The reference nido-carborane derivative (no metal ions) and unmodified nucleosides were not as effective.

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PMC11320834

We found two uncertain significance variants (VUS) throughout all samples (Table 2).

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PMC11525028

Protein level of ASNS in ATF4-KD 143B (left) and HOS (right) cells. (

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PMC11655536

F, G Western Blot detect the expression of LAMP1 of RPMI-8226 (F) and U266 (G) treated HA at 10 μM for 48 h and statistical analysis of LAMP1 expression, normalized by tubulin.

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PMC10329237

This technique is based on the dismutation of this radical by SOD and the competition between the pyrogallol autoxidation by O2•¯. A unit of Cu, Zn-SOD activity is determined as the quantity of enzyme needed for causing 50% inhibition of pyrogallol autoxidation.

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PMC11088135

Long non-coding RNAs (lncRNAs) are greater than 200 nucleotides in length and do not encode proteins .

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PMC9429973

Associations between baseline sBCMA levels and baseline patient characteristics or response to treatment were evaluated using an unpaired 2-sample Wilcoxon test (significance level: p≤0.05).

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PMC11568601

The identified DEGs included HSPA5 (encoding BiP) and ERN1 (encoding the IRE1 protein), as well as apoptosis-associated gene DDIT3 (encoding the CHOP protein).

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PMC11699178

Cell experiments were conducted in triplicate. *

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PMC9325715

The comparison between cytotoxicity of Fe-bLTF with iron citrate was performed at the same iron concentration in mM (determined by ICP-MS).

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PMC11802929

PBMCs from 62 participants were thawed for CD8 T cell enrichment (Human CD8 T cell Isolation Kit, Miltenyi Biotec) according to the manufacturer’s protocol then incubated with Human TruStain FcX blocking reagent (422302, BioLegend) for 10 min at 4 °C before wash.

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PMC7351993

First, to reduce the local stress concentration in the bonding process, we formed a grating pattern on the borosilicate glass surface of the base and cover layers by using the dry etching technique.

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PMC7504302

The invention of a series of rapidly evolving large-scale genomic and transcriptomic sequencing technologies facilitated the detection and identification of novel mutations and gene expression deregulations in cancer.

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PMC11052306

Of interest are also more “inorganic” dendrimers, in particular, those having either phosphorus or silicon at each branching point, which were reviewed early and more recently .

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PMC9429973

We are also encouraged to see a significant increase in the number of single unit transfusions, in line with NICE Guidance.

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PMC11489351

Scale bars represent 20 μm.

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PMC11683240

α1AT is represented in gray carton and pertussis toxin in colored surfaces, S1, green; S2, turquoise; S3, purple; S4, red; S5, yellow.

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PMC11621493

Image data were acquired in z-stacks with a resolution of 1,024 × 1,024 pixels with a scan speed of 600 Hz in unidirectional scan mode.

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PMC9429973

The patients at risk were classified by ThroLy score (>1), by Khorana score (≥2), and Vienna CATS score (expressed as predicted 6 months risk for venous TE (VTE) development).

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PMC11574029

Proteins encoded by Notch genes act as transmembrane receptors involved in various biological processes, including cell fate determination, embryonic development, organ formation, and tissue repair .

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PMC10125312

Further details on synthesis, surface modification, and optical measurements are described in the Supporting Information (SI).

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PMC11470999

In vitro anti‐melanoma efficacies of PF‐Biotin in B16 and A375 cells indicated that the inclusion of biotin did not significantly affect PF's inhibitory activities against melanoma (Figures 1B and 3B).

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PMC11706776

It can be hypothesized that the association between patient survival and KCNN1 expression, demonstrated in two independent cohorts of patients, is closely linked to the ability of KCNN1 to modulate the cellular response to chemotherapy, this process being strongly associated with patient survival .

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PMC11413393

RNA was then extracted from both the cytoplasmic and nuclear fractions using the Qiagen RNeasy mini kit.

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