OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9910796	The putative transmembrane segments (TM) of pEP84R, the N-myristoyl moiety of pp220NT, the His-V5 (pp220NT) and Flag (pEP84R) tags, and the regions corresponding to p5 and p34 products derived from pp220 are indicated. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7917457	APCs were pulsed with tumor antigen-containing peptides, with or without the polylysine modification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "APCs", "were", "pulsed", "with", "tumor", "antigen-containing", "pepti...
PMC11549612	These databases serve as valuable resources for researchers, providing curated data on gene expression, methylation, and clinical associations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "databases", ...
PMC10890307	All values are reported as the mean ± s.e.m.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "values", "are", "reported", "as", "the", "mean", "±", "s.e.m", "." ] } ]
PMC11502962	However, the counts of infiltrating cells differed between the two tumor samples ( Table 2 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "counts", "of", "infi...
PMC8009078	Compound A1, phytochemical obtained from ethanolic extract of the M. alba fruits.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compound", "A1", ",", "phytochemical", "obtained", "from", "ethanolic", "ex...
PMC11411004	All conditions were performed in three independent replicates, and the data are expressed as the mean ± standard deviation (SD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", ...
PMC11306331	n.s.:	[ { "tags": [ "O", "O", "O" ], "tokens": [ "n.s", ".", ":" ] } ]
PMC9587866	The compounds are also anti-neoplastic agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "compounds", "are", "also", "anti-neoplastic", "agents", "." ] } ]
PMC11787355	One out of the survivors remained tumor-free macroscopically while the others experienced tumor recurrence at experimental endpoint (Supplementary Fig. 9c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "out",...
PMC11266100	It was also shown that electroporation with nanosecond duration PEF protocols ensured equivalent or even better transfection efficiency than standard µsPEF.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "was", "also...
PMC9844987	Bottom: Box-and-whisker plots of promoter expression split by each category of genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bottom", ":", "Box-and-whisker", "plots", "of", "promoter", "expression", "...
PMC5839394	Data acquisition was performed with CellQuest Pro (BD) software, and analyzed with WinList software (Verity Software House, Topsham, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	In contrast, URD Cords and MMRD showed a marked increase (+86% and +19.5%) The increase in cords and MMRD HCT was probably due to the easier access of these donors in a pandemic situation J. C. De La Rosa García, B. Diaz Roldan, A. J. Palma Vallellano, A. R. Carranco Falcón, R. Zapata Bautista Hematology; Hospital Juan Ramon Jiménez, Huelva.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11703992	7Metabolic analysis and drug sensitivity analysis of CD4+ Memory T cells in GCA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "7Metabolic", "analysis", "and", "drug", "sensitivity", "analysis", "of...
PMC11412721	Means ± SEM (n = 3). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Means", "±", "SEM", "(", "n", "=", "3", ")", ".", "(" ] } ]
PMC9105697	In total, 29 plasma samples of these 15 patients were analyzed; 8 of the 15 patients had “active disease” (primary tumor (n = 2) or metastatic disease (n = 6)), 7 were in complete remission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746942	Immunofluorescence staining for CD31, an endothelial cell marker, revealed a decrease in dermal angiogenesis and capillary formation in the S1PR3-KO mice (Fig. S2C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10891340	It can be inferred that herpesvirus enhances replication of itself through regulating mitophagy, ROS, and apoptosis to escape immunity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "can", "be",...
PMC7192625	We confirmed that polycomb marked chromatin identified through H3K27me3 peaks was more assortative than expected at random (Supplementary Figure S8A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "confir...
PMC11301931	Ferroptosis suppressor protein (FSP1) is a glutathione-independent suppressor of ferroptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ferroptosis", "suppressor", "protein", "(", "FSP1", ")", "is", "a", "glutathione...
PMC11638288	Additionally, the expression of CD107 (a marker for NK cell degranulation) on the cell surface was reduced, indicating impaired NK cell activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9219615	Reactive oxygen species (ROS) indicate cellular homeostatic disturbance, and their accumulation promotes apoptosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reactive", "oxygen", "species", "(", "ROS", ")", ...
PMC10975211	Kim et al. (2000) reported that the histone variant H2A was the precursor for a 39-amino acid sequence named buforin I that was sampled and isolated for the first time from the gastric tissue of Bufo bufo gargarizans, and presented promising antibacterial effects against a broad spectrum of pathogens, both G+ bacteria (B. subtilis, S. aureus) and G- bacteria (E. coli, S. typhimurium) as well as fungi (C. albicans, S. cerevisiae) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461874	The present study highlights the role of these two E2 enzymes, UBE2G1 and UBE2T, as potential modulators of daily oscillations of a variety of DBP-mediated physiological processes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11406030	Here, we demonstrated the presence of the LMTK3 protein in more than 98% of ovarian cancer tissues collected from a cohort of 204 early-stage (stage I–II) ovarian cancer patients representing diverse histological profiles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9243326	The SMRTbell template was annealed to the sequencing primer and bound to polymerase, and sequenced on the PacBio Sequel II platform by Gene Denovo Biotechnology Co. (Guangzhou, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5173112	In contrast, 26.2% and 14.1% ALD cells were detected in the corresponding cells treated with IL-8 (Figure 6F and 6G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11066331	Normalized stacked bar chart of selected m/z values as an average for individual cell mixtures (B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Normalized", "stacked", "bar", "chart", ...
PMC5034105	were prepared and fixed in chilled acetone at −20 °C for 10 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "were", "prepared", "and", "fixed", "in", "chilled", "acetone", "...
PMC9429973	This effect was increased over time even for the less spontaneously susceptible cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "effect", "was", "increased", "over", "time", "even", "for", "...
PMC9429973	Image: Summary/Conclusion: Pharmacologic activation of Nrf2 by IMR-261 in a mouse model of iron overload activates hepcidin synthesis (likely via the Bmp6 signaling pathway) and decreases iron in serum, liver, spleen and kidney.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11743975	Upon blue-light illumination, the CRY2clust forms protein clusters in the cytosol and interacts with the Tom20-CIBN-GFP to rapidly induce the aggregation of mitochondria in the cell (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11507371	In view of the sustained elevated basal Nrf2 translocation in A431 cells, increasing CAP exposure likely overwhelms their ability to handle oxidative stress, leading to apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10969097	Tumours were established by injecting 4 × 10 SKOV3 cells into each mouse, and when the tumours reached approximately 100 mm, the animals were randomly divided into four groups (n = 5 in each group) and treated with different combinations of cisplatin and SBSGL: (I) in the SBSGL group, mice underwent daily oral administration of SBSGL at a dose of 2 g/kg; (II) in the cisplatin group, mice were given cisplatin injections once a week at a dosage of 3 mg/kg; (III) in the combination group, mice were first treated with SBSGL for three days and then received SBSGL and cisplatin following the previously mentioned schedules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11409031	This particular model excels in accurately categorizing patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "particular", "model", "excels", "in", "accurately", "categorizing", "patients", "." ] } ]
PMC9621239	B and C) The mRNA expressions of MYC in Huh 7 (B) and Bel-7404 (C) were assessed using a quantitative polymerase chain reaction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC6379402	We found that these datasets largely disagree with each other, as the genes that are found to be interacting in one dataset are rarely found to be interacting in another one (see Supplementary Fig. 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8073654	Table 1 summarizes the various bioactivities of the extracts, solvent fractions, and compounds from Z. cassumunar that have been reported.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "1",...
PMC11751675	Tashironin showed IC50 values of 0.48 mM (SI = 6.3) for inhibiting HBsAg secretion and 0.15 mM (SI = 20.1) for inhibiting HBeAg secretion, while tashironin A exhibited IC50 values of 0.49 mM (SI = 2.1) and 0.15 mM (SI = 6.7), respectively, in HBV-transfected HepG2.2.15 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11023271	Proteinase K was from Takara Bio (cat#ST3041).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proteinase", "K", "was", "from", "Takara", "Bio", "(", "cat#ST3041", ")", "." ] } ]
PMC8839885	Our recent research demonstrated that quercetin and fisetin restored platinum sensitivity to OC cells co-cultured with MSC by promoting ERK1/2 activation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "recent", "...
PMC11025866	Cells were harvested 6 h and 24 h post-treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "harvested", "6", "h", "and", "24", "h", "post-treatment", "." ] } ]
PMC10093184	The calculation of RNA expression levels was performed as described above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "calculation", "of", "RNA", "expression", "levels", "was", "performed", "as", "...
PMC11248911	The new compounds showed promising cytotoxicity against MCF-7 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "new", "compounds", "showed", "promising", "cytotoxicity", "against", "MCF-7", "cell", "li...
PMC11622247	Most of the cells (60–80% of 10 cells, Fig. S7†) survived a 25 ms, single 240 V pulse, which allowed relatively weak staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8336407	The criterion for statistical significance is expressed as p < 0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "criterion", "for", "statistical", "significance", "is", "expressed", "as", "p", ...
PMC11700340	Likewise, this gene is excessively too in colorectal, liver, and breast cancer , Linagliptin can target Cyclin Dependent Kinase 1 (CDK1), which plays a critical role in the cell cycle and phosphorylates diverse substrate proteins comprising histones H1, laminin, and Rb.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240052	Error bars represent mean ± SD. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "represent", "mean", "±", "SD", ".", "*" ] } ]
PMC10605143	Non-tumorigenic human breast epithelial cell lines, MCF10A (authenticated in 2016) and MCF12A (ATCC, Manassas, VA, USA), were cultured in DMEM/F12 medium supplemented with 5% horse serum (BioWest, Nuaillé, France), 5 µg/mL insulin (Sigma-Aldrich, Saint Louis, MO, USA), 0.5 µg/mL hydrocortisone (Sigma-Aldrich), 20 ng/mL EGF (Sigma-Aldrich).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11750712	Relapsed/refractory peripheral T cell lymphomas (PTCLs) are aggressive tumors with a poor prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relapsed/refractory", "peripheral", "T", "cell", "lymphomas", "("...
PMC9412887	However, cellular uptake was significantly blocked after incubation of the cells with β-cyclodextrin, indicating the mechanism of caveolae/lipid raft-mediated endocytosis for the internalization of nanomicelles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2944824	Hr is developmentally regulated in the rat brain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hr", "is", "developmentally", "regulated", "in", "the", "rat", "brain", "." ] } ]
PMC11545737	DAMPs from intracellular compartments include molecules from: i. cytosol (heat-shock proteins, S100 proteins, cyclophilin A, F-actin, amyloid beta, ATP, uric acid); nucleus (histones, HMGB1, HMGN1, interleukin-1α, interleukin-33, SAP130, DNA, RNA); mitochondria (mtDNA, TFAM, formyl peptides, mROS); endoplasmic reticulum (calreticulin); granules (defensin, cathelicidins LL37, eosinophil-derived neurotoxin, granulysin); plasma membrane (syndecans, glypicans) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9219615	The MAP kinase (MAPK) pathway plays an essential role in extracellular signal transduction and is often dysregulated in many cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "MAP",...
PMC9220170	For the “wound healing assay”, disruption of the structure of the cell monolayer was performed by pushing the monolayer with a pipette tip, which was like a “wound”.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8735881	The encoding sequence of scFv or a bifunctional inhibitor was genetically linked with the sequences encoding a His tag and the GPI attachment signal of DAF.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10847511	While large publicly available cancer cell line databases are invaluable for preclinical drug discovery and biomarker development, the association between homologous recombination deficiency (HRD) and drug sensitivity in these resources remains unclear.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11610461	Total RNA was extracted from tissues and cells by TRIzol reagent (Invitrogen, ThermoFisherScientific, Shanghai, China) following the manufacturer’s protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11676169	Together, our data suggest that BCAT1 positively regulates the c-NHEJ pathway activity in human T-ALL and that BCAT1-depleted human T-ALLs are locked in a state of dampened DSB DNA repair.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10747139	RAPTA-C acts synergistically in association with other drugs, such as the EGFR inhibitor erlotinib, the tyrosine kinase inhibitor axitinib, PI3K, and the mTOR inhibitor BEZ-235, as demonstrated by in vivo models .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11409031	8 PFN1 is upregulated in human OV cell line A2780. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "8", "PFN1", "is", "upregulated", "in", "human", "OV", "cell", "line", "A2780...
PMC11772585	The duration of color development noted during this process is regarded as the final time for IHC color development of the tissue sections discussed in this article, and this duration will remain consistent for subsequent sections across each group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Herein, CR examined 38 of our active multiple myeloma (MM) trials since 2016 with a focus on CAR T therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Herein"...
PMC11715644	We plotted average cell density over time and found that cell density rises over the first 12 hours and stays higher outside the microchannels, compared to inside (Fig. 1C, D and Fig. S2A, B, ESI†).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10329074	The difference of YBX3 expression in samples with different histological grades. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "difference", "of", "YBX3", "expression", "in", "samples", "with", "differ...
PMC9985266	Subsequently, cells were incubated with Triton X-100 (Beyotime) permeabilization buffer for 15 min and then blocked with QuickBlock™ (Beyotime) for 30 min at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11512230	Moreover, TMV SP conjugated with doxorubicin or containing it inside the particles have an inhibitory effect on breast cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "...
PMC9164404	Lipidomics study showed that Abplatin induced the disorder of glycerophospholipids and sphingolipids Schematic illustration showing Abplatin inhibited the tumor growth on a patient-derived tumor xenograft model of hepatocellular carcinoma (PDX) and its comparative multi-omics study with cisplatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	Ears were mechanically opened in two sheets with two forceps and were maintained in RPMI.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ears", "were", "mechanically", "opened", "in", "two", "shee...
PMC8382973	2P23 is an effective HIV membrane fusion inhibitor that may be a good entry inhibitor microbicide candidate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2P23", "is", "an", "effective", "HIV", "mem...
PMC10547921	Sixth, ADC payloads should have proper water solubility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sixth", ",", "ADC", "payloads", "should", "have", "proper", "water", "solubility", "." ] } ]
PMC9429973	Disease induced by Evi1+ cells presented with more extensive leukemic organ infiltration than Evi1- AML.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Disease", "induced", "by", "Evi1", "+", "cells", ...
PMC11670407	6The OTULIN-GPX4 axis conferred resistance to cisplatin in osteosarcoma by blocking the mitochondrial apoptotic pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "6The", "OTULIN-GPX4", "axis", "conferred", "resistance", "to", ...
PMC11806818	Fe3O4@Au nanozyme has peroxidase-like activity, which not only catalyzes H2O2 reduction, but also serves as a scaffold for carrying a large number of electroactive substances and DNA probes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787381	After separation of the free bambuterol on a Sephadex column, the bambuterol-loaded liposomes were characterized (Supplementary table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "separation", ...
PMC11629143	To explore whether this mechanism influences the expression of mAb transgenes from the CMV promoter in CHO cells, ChIP‐qPCR was used to assess enrichment at the promoter and transgene of the activated form of Pol II, which is phosphorylated on serine 2 of its heptad repeats (Pol II S2P).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11052306	The corresponding monomers (x-M, with x = 2–4) were also synthesized .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "corresponding", "monomers", "(", "x-M", ",", "with", "x",...
PMC11635087	Schyzon, which has retained the primitive characteristics of ancestral algae, exist in highly acidic and volcanic hot springs that seem to reflect prehistoric Earth environmental conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705630	ISGF3 is a transcription factor composed of STAT1, STAT2 and IRF9 and can be activated by increased expression or phosphorylation of its subunits, STAT1 and STAT2 30.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11413393	Source data are provided as a Source Data file.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Source", "data", "are", "provided", "as", "a", "Source", "Data", "file", "." ] } ]
PMC10958426	Box plot of the fraction of high CV genes in each chromosomal region.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Box", "plot", "of", "the", "fraction", "of", "high", "CV", "genes", ...
PMC11459296	For immunophenotyping of immune cell subsets within the human graft, CD19-APC-H7 (SJ25C1, BD-Pharmingen), CD3-PECy7 (UCHT1, BD-Pharmingen), CD4-BV421 (RPA-T4, BD-Horizon), CD8-BV510 (SK1, BD-Horizon), CD7-FITC (B M-T701, BD-Pharmingen) and CD33-APC (WM53, BD-Pharmingen) antibodies were used to identify B cells (CD19+), CD4+ (CD3+CD4+) or CD8+ (CD3+CD8+) T cells, NK cells (CD3-CD7+)1517 and monocytes (CD33+) by flow cytometry on a FACSCanto-II cytometer running FACSDiva software (BD-Biosciences).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10975211	This feature is achieved by binding to the bacterial membrane and disrupting its integrity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "feature", "is", "achieved", "by", "binding", "to", "the"...
PMC11271800	PD-L1 T cells infiltrating the tumor act on PD-1 macrophages within the tumor and induce polarization of M2 TAMs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PD-L1", "T", "cells", "infiltrati...
PMC11585254	Further, we found that β-arrestins are only required for CXCR5 desensitization and are dispensable for internalization or signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", ",", "we", "found", ...
PMC9776316	Our previous study demonstrated that DGKA activates the transcription factor cJUN in ovarian cancer cells upon cisplatin treatment .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "previous", "study", "demonstrated", ...
PMC11449273	SKOV-3 ovarian carcinoma cell line was purchased from American Type Culture Collection (ATCC) and cultured in Dulbecco’s modified eagle medium: F12 medium (DMEM/F12, 1:1) supplemented with 10% fetal bovine serum, 1% penicillin-streptomycin and 5 μg/mL kanamycin.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: Enrollment for the trial has been completed, with a total of 31 patients enrolled globally.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Enrollment", "for", "t...
PMC11718031	On the other hand, only minor variations were seen for mannosylation (Fig. 7C) and afucosylation (Fig. 7D), although CD-CHO with IS CHO-CD D12.7 resulted in 2.5% higher afucosylation than the control CD-CHO with Dynamis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11745600	However, Ins1 NOG mice exhibited significantly reduced pancreatic insulin content (Figure 3N) and plasma insulin levels in the nonfasting state (Figure 3O) compared with wild-type mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11788920	This suggests RNP1 (the enhancer) compensates for the suppression caused by RNP2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "suggests", "RNP1", "(", "the", "enhancer", ")", "compens...
PMC10940855	BM microenvironment cells and CD269 (TNFRSF17/BCMA) multiple myeloma cells were isolated from primary human BM aspirates (34) as follows.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BM", ...
PMC11025866	Increased expression of CHAC1 and SLC7A11 is seen in cells treated for 6 h with VPA or VPM (10 mM) in the absence or presence of butyrate (NaB; 3 mM) validated by RT-qPCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11247842	Furthermore, our data suggested that both CM and SCS have QTL on BTA18 and BTA19.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "our", "data", "suggested", "that",...
PMC3675084	Cells were then washed with PBS before incubating with AlexaFluor 488 goat anti-mouse secondary antibody (Invitrogen, 1∶1000 dilution) at 4°C for 1 hour.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11335267	Fitted apparent diffusion coefficient (ADC) values obtained from the arcuate nucleus (ARC), the ventromedial hypothalamus (VMH) or the dorsomedial nucleus (DMN) using fDWI in fed or fasted mice (blue dots, wild type; red dots, Alx3-ko).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6461034	This reduces the chance of missing important kinases, as illustrated by the case of AXL in the HCC827‐ER3 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "This", "reduce...
PMC11711127	As previously mentioned, introduction into an inflammatory environment has the potential to convert Tregs to an effector memory phenotype, and tolDCs into their immunogenic ‘fully mature’ counterpart and thus may exacerbate disease in each case (184185).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11720107	In the BJ cell line, the Morado cultivar increased caspase-3 activity at all studied concentrations (0.062 to 1.000 mg/mL), while the Violeta cultivar slightly decreased caspase-3 activity at the two highest concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9910796

The putative transmembrane segments (TM) of pEP84R, the N-myristoyl moiety of pp220NT, the His-V5 (pp220NT) and Flag (pEP84R) tags, and the regions corresponding to p5 and p34 products derived from pp220 are indicated. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7917457

APCs were pulsed with tumor antigen-containing peptides, with or without the polylysine modification.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "APCs", "were", "pulsed", "with", "tumor", "antigen-containing", "pepti...

PMC11549612

These databases serve as valuable resources for researchers, providing curated data on gene expression, methylation, and clinical associations.

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PMC10890307

All values are reported as the mean ± s.e.m.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "values", "are", "reported", "as", "the", "mean", "±", "s.e.m", "." ] } ]

PMC11502962

However, the counts of infiltrating cells differed between the two tumor samples ( Table 2 ).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "counts", "of", "infi...

PMC8009078

Compound A1, phytochemical obtained from ethanolic extract of the M. alba fruits.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compound", "A1", ",", "phytochemical", "obtained", "from", "ethanolic", "ex...

PMC11411004

All conditions were performed in three independent replicates, and the data are expressed as the mean ± standard deviation (SD).

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PMC11306331

n.s.:

[ { "tags": [ "O", "O", "O" ], "tokens": [ "n.s", ".", ":" ] } ]

PMC9587866

The compounds are also anti-neoplastic agents.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "compounds", "are", "also", "anti-neoplastic", "agents", "." ] } ]

PMC11787355

One out of the survivors remained tumor-free macroscopically while the others experienced tumor recurrence at experimental endpoint (Supplementary Fig. 9c).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "out",...

PMC11266100

It was also shown that electroporation with nanosecond duration PEF protocols ensured equivalent or even better transfection efficiency than standard µsPEF.

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PMC9844987

Bottom: Box-and-whisker plots of promoter expression split by each category of genes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bottom", ":", "Box-and-whisker", "plots", "of", "promoter", "expression", "...

PMC5839394

Data acquisition was performed with CellQuest Pro (BD) software, and analyzed with WinList software (Verity Software House, Topsham, USA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

In contrast, URD Cords and MMRD showed a marked increase (+86% and +19.5%) The increase in cords and MMRD HCT was probably due to the easier access of these donors in a pandemic situation J. C. De La Rosa García, B. Diaz Roldan, A. J. Palma Vallellano, A. R. Carranco Falcón, R. Zapata Bautista Hematology; Hospital Juan Ramon Jiménez, Huelva.,

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11703992

7Metabolic analysis and drug sensitivity analysis of CD4+ Memory T cells in GCA.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "7Metabolic", "analysis", "and", "drug", "sensitivity", "analysis", "of...

PMC11412721

Means ± SEM (n = 3). (

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PMC9105697

In total, 29 plasma samples of these 15 patients were analyzed; 8 of the 15 patients had “active disease” (primary tumor (n = 2) or metastatic disease (n = 6)), 7 were in complete remission.

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PMC11746942

Immunofluorescence staining for CD31, an endothelial cell marker, revealed a decrease in dermal angiogenesis and capillary formation in the S1PR3-KO mice (Fig. S2C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10891340

It can be inferred that herpesvirus enhances replication of itself through regulating mitophagy, ROS, and apoptosis to escape immunity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "can", "be",...

PMC7192625

We confirmed that polycomb marked chromatin identified through H3K27me3 peaks was more assortative than expected at random (Supplementary Figure S8A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "confir...

PMC11301931

Ferroptosis suppressor protein (FSP1) is a glutathione-independent suppressor of ferroptosis.

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PMC11638288

Additionally, the expression of CD107 (a marker for NK cell degranulation) on the cell surface was reduced, indicating impaired NK cell activation.

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PMC9219615

Reactive oxygen species (ROS) indicate cellular homeostatic disturbance, and their accumulation promotes apoptosis .

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PMC10975211

Kim et al. (2000) reported that the histone variant H2A was the precursor for a 39-amino acid sequence named buforin I that was sampled and isolated for the first time from the gastric tissue of Bufo bufo gargarizans, and presented promising antibacterial effects against a broad spectrum of pathogens, both G+ bacteria (B. subtilis, S. aureus) and G- bacteria (E. coli, S. typhimurium) as well as fungi (C. albicans, S. cerevisiae) .

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PMC11461874

The present study highlights the role of these two E2 enzymes, UBE2G1 and UBE2T, as potential modulators of daily oscillations of a variety of DBP-mediated physiological processes.

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PMC11406030

Here, we demonstrated the presence of the LMTK3 protein in more than 98% of ovarian cancer tissues collected from a cohort of 204 early-stage (stage I–II) ovarian cancer patients representing diverse histological profiles.

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PMC9243326

The SMRTbell template was annealed to the sequencing primer and bound to polymerase, and sequenced on the PacBio Sequel II platform by Gene Denovo Biotechnology Co. (Guangzhou, China).

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PMC5173112

In contrast, 26.2% and 14.1% ALD cells were detected in the corresponding cells treated with IL-8 (Figure 6F and 6G).

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PMC11066331

Normalized stacked bar chart of selected m/z values as an average for individual cell mixtures (B).

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PMC5034105

were prepared and fixed in chilled acetone at −20 °C for 10 min.

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PMC9429973

This effect was increased over time even for the less spontaneously susceptible cells.

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PMC9429973

Image: Summary/Conclusion: Pharmacologic activation of Nrf2 by IMR-261 in a mouse model of iron overload activates hepcidin synthesis (likely via the Bmp6 signaling pathway) and decreases iron in serum, liver, spleen and kidney.

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PMC11743975

Upon blue-light illumination, the CRY2clust forms protein clusters in the cytosol and interacts with the Tom20-CIBN-GFP to rapidly induce the aggregation of mitochondria in the cell (Figure 1).

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PMC11507371

In view of the sustained elevated basal Nrf2 translocation in A431 cells, increasing CAP exposure likely overwhelms their ability to handle oxidative stress, leading to apoptosis.

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PMC10969097

Tumours were established by injecting 4 × 10 SKOV3 cells into each mouse, and when the tumours reached approximately 100 mm, the animals were randomly divided into four groups (n = 5 in each group) and treated with different combinations of cisplatin and SBSGL: (I) in the SBSGL group, mice underwent daily oral administration of SBSGL at a dose of 2 g/kg; (II) in the cisplatin group, mice were given cisplatin injections once a week at a dosage of 3 mg/kg; (III) in the combination group, mice were first treated with SBSGL for three days and then received SBSGL and cisplatin following the previously mentioned schedules.

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PMC11409031

This particular model excels in accurately categorizing patients.

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PMC9621239

B and C) The mRNA expressions of MYC in Huh 7 (B) and Bel-7404 (C) were assessed using a quantitative polymerase chain reaction.

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PMC6379402

We found that these datasets largely disagree with each other, as the genes that are found to be interacting in one dataset are rarely found to be interacting in another one (see Supplementary Fig. 4).

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PMC8073654

Table 1 summarizes the various bioactivities of the extracts, solvent fractions, and compounds from Z. cassumunar that have been reported.

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PMC11751675

Tashironin showed IC50 values of 0.48 mM (SI = 6.3) for inhibiting HBsAg secretion and 0.15 mM (SI = 20.1) for inhibiting HBeAg secretion, while tashironin A exhibited IC50 values of 0.49 mM (SI = 2.1) and 0.15 mM (SI = 6.7), respectively, in HBV-transfected HepG2.2.15 cells.

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PMC11023271

Proteinase K was from Takara Bio (cat#ST3041).

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PMC8839885

Our recent research demonstrated that quercetin and fisetin restored platinum sensitivity to OC cells co-cultured with MSC by promoting ERK1/2 activation .

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PMC11025866

Cells were harvested 6 h and 24 h post-treatment.

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PMC10093184

The calculation of RNA expression levels was performed as described above.

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PMC11248911

The new compounds showed promising cytotoxicity against MCF-7 cell line.

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PMC11622247

Most of the cells (60–80% of 10 cells, Fig. S7†) survived a 25 ms, single 240 V pulse, which allowed relatively weak staining.

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PMC8336407

The criterion for statistical significance is expressed as p < 0.05.

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PMC11700340

Likewise, this gene is excessively too in colorectal, liver, and breast cancer , Linagliptin can target Cyclin Dependent Kinase 1 (CDK1), which plays a critical role in the cell cycle and phosphorylates diverse substrate proteins comprising histones H1, laminin, and Rb.

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PMC11240052

Error bars represent mean ± SD. *

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PMC10605143

Non-tumorigenic human breast epithelial cell lines, MCF10A (authenticated in 2016) and MCF12A (ATCC, Manassas, VA, USA), were cultured in DMEM/F12 medium supplemented with 5% horse serum (BioWest, Nuaillé, France), 5 µg/mL insulin (Sigma-Aldrich, Saint Louis, MO, USA), 0.5 µg/mL hydrocortisone (Sigma-Aldrich), 20 ng/mL EGF (Sigma-Aldrich).

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PMC11750712

Relapsed/refractory peripheral T cell lymphomas (PTCLs) are aggressive tumors with a poor prognosis.

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PMC9412887

However, cellular uptake was significantly blocked after incubation of the cells with β-cyclodextrin, indicating the mechanism of caveolae/lipid raft-mediated endocytosis for the internalization of nanomicelles.

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PMC2944824

Hr is developmentally regulated in the rat brain.

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PMC11545737

DAMPs from intracellular compartments include molecules from: i. cytosol (heat-shock proteins, S100 proteins, cyclophilin A, F-actin, amyloid beta, ATP, uric acid); nucleus (histones, HMGB1, HMGN1, interleukin-1α, interleukin-33, SAP130, DNA, RNA); mitochondria (mtDNA, TFAM, formyl peptides, mROS); endoplasmic reticulum (calreticulin); granules (defensin, cathelicidins LL37, eosinophil-derived neurotoxin, granulysin); plasma membrane (syndecans, glypicans) .

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PMC9219615

The MAP kinase (MAPK) pathway plays an essential role in extracellular signal transduction and is often dysregulated in many cancers.

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PMC9220170

For the “wound healing assay”, disruption of the structure of the cell monolayer was performed by pushing the monolayer with a pipette tip, which was like a “wound”.

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PMC8735881

The encoding sequence of scFv or a bifunctional inhibitor was genetically linked with the sequences encoding a His tag and the GPI attachment signal of DAF.

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PMC10847511

While large publicly available cancer cell line databases are invaluable for preclinical drug discovery and biomarker development, the association between homologous recombination deficiency (HRD) and drug sensitivity in these resources remains unclear.

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PMC11610461

Total RNA was extracted from tissues and cells by TRIzol reagent (Invitrogen, ThermoFisherScientific, Shanghai, China) following the manufacturer’s protocol.

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PMC11676169

Together, our data suggest that BCAT1 positively regulates the c-NHEJ pathway activity in human T-ALL and that BCAT1-depleted human T-ALLs are locked in a state of dampened DSB DNA repair.

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PMC10747139

RAPTA-C acts synergistically in association with other drugs, such as the EGFR inhibitor erlotinib, the tyrosine kinase inhibitor axitinib, PI3K, and the mTOR inhibitor BEZ-235, as demonstrated by in vivo models .

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PMC11409031

8 PFN1 is upregulated in human OV cell line A2780. (

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PMC11772585

The duration of color development noted during this process is regarded as the final time for IHC color development of the tissue sections discussed in this article, and this duration will remain consistent for subsequent sections across each group.

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PMC9429973

Herein, CR examined 38 of our active multiple myeloma (MM) trials since 2016 with a focus on CAR T therapy.

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PMC11715644

We plotted average cell density over time and found that cell density rises over the first 12 hours and stays higher outside the microchannels, compared to inside (Fig. 1C, D and Fig. S2A, B, ESI†).

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PMC10329074

The difference of YBX3 expression in samples with different histological grades. (

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PMC9985266

Subsequently, cells were incubated with Triton X-100 (Beyotime) permeabilization buffer for 15 min and then blocked with QuickBlock™ (Beyotime) for 30 min at 37 °C.

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PMC11512230

Moreover, TMV SP conjugated with doxorubicin or containing it inside the particles have an inhibitory effect on breast cancer cells .

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PMC9164404

Lipidomics study showed that Abplatin induced the disorder of glycerophospholipids and sphingolipids Schematic illustration showing Abplatin inhibited the tumor growth on a patient-derived tumor xenograft model of hepatocellular carcinoma (PDX) and its comparative multi-omics study with cisplatin.

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PMC11224020

Ears were mechanically opened in two sheets with two forceps and were maintained in RPMI.

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PMC8382973

2P23 is an effective HIV membrane fusion inhibitor that may be a good entry inhibitor microbicide candidate.

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PMC10547921

Sixth, ADC payloads should have proper water solubility.

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PMC9429973

Disease induced by Evi1+ cells presented with more extensive leukemic organ infiltration than Evi1- AML.

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PMC11670407

6The OTULIN-GPX4 axis conferred resistance to cisplatin in osteosarcoma by blocking the mitochondrial apoptotic pathway.

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PMC11806818

Fe3O4@Au nanozyme has peroxidase-like activity, which not only catalyzes H2O2 reduction, but also serves as a scaffold for carrying a large number of electroactive substances and DNA probes.

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PMC11787381

After separation of the free bambuterol on a Sephadex column, the bambuterol-loaded liposomes were characterized (Supplementary table 1).

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PMC11629143

To explore whether this mechanism influences the expression of mAb transgenes from the CMV promoter in CHO cells, ChIP‐qPCR was used to assess enrichment at the promoter and transgene of the activated form of Pol II, which is phosphorylated on serine 2 of its heptad repeats (Pol II S2P).

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PMC11052306

The corresponding monomers (x-M, with x = 2–4) were also synthesized .

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PMC11635087

Schyzon, which has retained the primitive characteristics of ancestral algae, exist in highly acidic and volcanic hot springs that seem to reflect prehistoric Earth environmental conditions.

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PMC11705630

ISGF3 is a transcription factor composed of STAT1, STAT2 and IRF9 and can be activated by increased expression or phosphorylation of its subunits, STAT1 and STAT2 30.

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PMC11413393

Source data are provided as a Source Data file.

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PMC10958426

Box plot of the fraction of high CV genes in each chromosomal region.

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PMC11459296

For immunophenotyping of immune cell subsets within the human graft, CD19-APC-H7 (SJ25C1, BD-Pharmingen), CD3-PECy7 (UCHT1, BD-Pharmingen), CD4-BV421 (RPA-T4, BD-Horizon), CD8-BV510 (SK1, BD-Horizon), CD7-FITC (B M-T701, BD-Pharmingen) and CD33-APC (WM53, BD-Pharmingen) antibodies were used to identify B cells (CD19+), CD4+ (CD3+CD4+) or CD8+ (CD3+CD8+) T cells, NK cells (CD3-CD7+)1517 and monocytes (CD33+) by flow cytometry on a FACSCanto-II cytometer running FACSDiva software (BD-Biosciences).

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PMC10975211

This feature is achieved by binding to the bacterial membrane and disrupting its integrity.

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PMC11271800

PD-L1 T cells infiltrating the tumor act on PD-1 macrophages within the tumor and induce polarization of M2 TAMs.

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PMC11585254

Further, we found that β-arrestins are only required for CXCR5 desensitization and are dispensable for internalization or signaling.

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PMC9776316

Our previous study demonstrated that DGKA activates the transcription factor cJUN in ovarian cancer cells upon cisplatin treatment .

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PMC11449273

SKOV-3 ovarian carcinoma cell line was purchased from American Type Culture Collection (ATCC) and cultured in Dulbecco’s modified eagle medium: F12 medium (DMEM/F12, 1:1) supplemented with 10% fetal bovine serum, 1% penicillin-streptomycin and 5 μg/mL kanamycin.

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PMC9429973

Results: Enrollment for the trial has been completed, with a total of 31 patients enrolled globally.

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PMC11718031

On the other hand, only minor variations were seen for mannosylation (Fig. 7C) and afucosylation (Fig. 7D), although CD-CHO with IS CHO-CD D12.7 resulted in 2.5% higher afucosylation than the control CD-CHO with Dynamis.

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PMC11745600

However, Ins1 NOG mice exhibited significantly reduced pancreatic insulin content (Figure 3N) and plasma insulin levels in the nonfasting state (Figure 3O) compared with wild-type mice.

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PMC11788920

This suggests RNP1 (the enhancer) compensates for the suppression caused by RNP2.

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PMC10940855

BM microenvironment cells and CD269 (TNFRSF17/BCMA) multiple myeloma cells were isolated from primary human BM aspirates (34) as follows.

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PMC11025866

Increased expression of CHAC1 and SLC7A11 is seen in cells treated for 6 h with VPA or VPM (10 mM) in the absence or presence of butyrate (NaB; 3 mM) validated by RT-qPCR.

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PMC11247842

Furthermore, our data suggested that both CM and SCS have QTL on BTA18 and BTA19.

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PMC3675084

Cells were then washed with PBS before incubating with AlexaFluor 488 goat anti-mouse secondary antibody (Invitrogen, 1∶1000 dilution) at 4°C for 1 hour.

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PMC11335267

Fitted apparent diffusion coefficient (ADC) values obtained from the arcuate nucleus (ARC), the ventromedial hypothalamus (VMH) or the dorsomedial nucleus (DMN) using fDWI in fed or fasted mice (blue dots, wild type; red dots, Alx3-ko).

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PMC6461034

This reduces the chance of missing important kinases, as illustrated by the case of AXL in the HCC827‐ER3 cell line.

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PMC11711127

As previously mentioned, introduction into an inflammatory environment has the potential to convert Tregs to an effector memory phenotype, and tolDCs into their immunogenic ‘fully mature’ counterpart and thus may exacerbate disease in each case (184185).

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PMC11720107

In the BJ cell line, the Morado cultivar increased caspase-3 activity at all studied concentrations (0.062 to 1.000 mg/mL), while the Violeta cultivar slightly decreased caspase-3 activity at the two highest concentrations.

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