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OTAR3088
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BioData-CellLine_annotated

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PMC11592837
Although we obtained similar results, we wondered whether our applied dose of DOX was less effective compared to ETP, thus leading to the observed timely delay in DDR.
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PMC10747160
Since Raji cells are derived from B cells, which are active immune cells, they could be capable of binding to viral pathogen epitopes via Toll-like receptors, B-cell receptors, or complement receptors and undergoing activation .
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PMC11684821
While it is possible to grow HLA A*02:01 CD8 or CD4 T cells bearing supraphysiologic affinity HLA A*02:01-restricted TCRs, these T cells react to an HLA A*02:01 target cells without the need for cognate antigen as they presumably start to recognize some self antigens with sufficient affinity to activate (48).
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PMC11615828
After aspirating the inactivation solution, the tissues were gently triturated 20–30 times into a suspension of neurons using a 10 mL plastic pipette.
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PMC9014716
OXA lyophilized powder was dissolved in 5% glucose solution and stored at −20°C for following-up use.
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PMC11790971
Four single-origin recombinant CHO cell lines with distinct production phenotypes were provided by GSK (Stevenage, United Kingdom).
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PMC11637284
as in (A) but an MSA depicting the T. brucei p166 region D1479-L1499 is shown.
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PMC11321678
Most medulloblastoma cells expressed at least one synaptogenic gene, as indicated by the green color.
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PMC11742670
Fig. 10Interpretable Explanations for Compound Selection and Feature Significance in IC50 Predictions for A-375 Cell Line.
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PMC11756514
Additionally, both MBL and langerin ECD were shown to interact with non-encapsulated S. aureus.
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PMC11502066
The overexpression of GPR30 has been reported in various human malignancies, such as breast, ovarian and endometrial cancers, being associated with tumor growth and metastatic phenotype, and related to reduced survival rates in patients .
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PMC9429973
One patient from the high-dose group (4.5-6.0 × 10 CAR T cells/kg) developed grade 1 neurotoxicity.
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PMC11670407
Similar functions of OTULIN have been reported in previous studies, where the absence of OTULIN in certain cells, such as fibroblasts, led to the proteasomal degradation of LUBAC components .
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PMC11519567
Fig. 4SS18-SSX condensates hijack endogenous SS18 upon synovial sarcomagenesis.
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PMC11708541
Toxalbumin ricinine 5 is obtained from Ricinus communis, produces castor beans.
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PMC10079526
First bioluminescence (BLI) measurement was carried out on day 8, followed by subsequent rounds of treatment and BLI measurements two times per week.
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PMC11351758
To the best of our knowledge, the effects of high glucose toxicity on NARP cells have not been explored.
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PMC11575040
After dividing these clean reads into multiple categories depending on NCBI human reference genes, we discovered that more than 90% of the reads could be mapped (Figure S1A).
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PMC11532793
Moreover, Gibbs sampling results in transcript replicate counts directly and does not require model optimization during every iteration, making it much faster than bootstrap sampling.
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PMC9635307
Different observation by others showing CEACAM1-induced B cell activation may be explained by the fact that the BCR was not stimulated at the same time as CEACAM1 stimulation in their study, and consequently the suppression of BCR signaling was not observed.
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PMC11625890
The love of science must have already been inspiring me at a young age.
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PMC11532793
For small-scale RNA-seq experiments, we expect our proposed pipeline to provide end-to-end DTE analyses in no more than half of the total computing time that was previously reported with bootstrap sampling by Baldoni et al. (13), with greater reductions for larger datasets.
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PMC11409031
Subsequently, an in-depth examination of the T cell subpopulations was carried out, revealing the presence of 14 distinct cell clusters.
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PMC9429973
Thirty co-morbidities were assessed using Elixhauser scoring.
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PMC11742431
Furthermore, the strategic incorporation of a tumor microenvironment‐responsive cleavage peptide at the N‐terminus of the ligand leads to the development of an innovative bispecific nanobody‐targeted, tumor microenvironment‐mediated PROTACs‐like protein drug for degradation, which we term BumPeD. This approach harnesses the tumor's own microenvironment to enhance the specificity and efficacy of protein degradation.
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PMC11144200
Meanwhile, mice in each group were injected with corresponding liposomes and antibodies.
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PMC9964654
The results showed that, after micelle encapsulation, [Au(cdc)2] was still able to maintain its cytotoxic activity against ovarian cancer cells and its antimicrobial activity against S. aureus Newman and glabrata CBS138.
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PMC9429973
These findings suggest that vaccine administration should be considered even early after anti CD20 therapy despite the reduced humoral immunity.
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PMC8658661
Another example of a gene with altered expression is the GPC3 gene encoding glypican-3, which is overexpressed in HepG2 cells and tumor cells in HCC .
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PMC11319300
This suggests deep conservation (Wong et al., 2020) of this enhancer that extends beyond the ORF shared by most primates.
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PMC9429973
Methods: For scNOVA analysis, blasts from four CK-AML patients were cultured in the presence of BrdU for the duration of one cell division, followed by single-cell template strand-sequencing (Strand-seq).
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PMC9065483
D–F) 786-0 cells were treated ± vanadate (150μM) ± gefitinib (10μM).
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PMC9429973
Median age at PTLD diagnosis was 49 years (interquartile range [IQR]: 33‒57) and median time to PTLD onset from transplant was 3 months (IQR: 1.9‒4.2).
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PMC11720107
The conducted experiments showed that all the studied extracts produced a lesser increase in ROS in normal BJ fibroblasts and were less toxic to these cells.
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PMC6627640
For each cell line, six biological replicates were tested at each concentration, and experiments were repeated at least twice on different days.
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PMC4485648
Moreover, hypoxia contributes to poor response of cancer patients to conventional anticancer therapies (3).
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PMC11711663
In our study, we observed 55 out of 77 events in MD Anderson data.
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PMC6771295
Secondary antibodies were diluted 1:1,000 and incubated for 1 h. Blots were developed with ECL substrate according to manufacturer's instructions (Pierce, Thermo Scientific, USA).
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PMC9429973
So, those preliminary results show an altered miRNA expression depending on the bone severity.
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PMC11476837
Brusatol (another natural NRF2 inhibitor) and luteolin increased the cytotoxic potential of 5-FU against gastric cancer cell line MKN-45 .
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PMC11723947
To control engraftment, a group of mice was also injected solely with the bone marrow cell mixture.
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PMC3035438
Correct integration of the constructs was confirmed by PCR analysis (primers provided in Supplementary Data S1) using the KOD FX enzyme (Toyobo) after isolation of genomic DNA using the Illustra GenomicPrep Mini Spin Kit (GE Healthcare).
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PMC9220170
It is known that the degree of collective cell migration is eliminated in the cell culture of many types of cancer.
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PMC8345486
Substitution of the adenosine at the C2′ position with ferra bis(dicarbollide) (compound 23) was the most efficient modification in relation to all the cell lines for which this compound was significantly more toxic than the unmodified cage.
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PMC9429973
Data returns were then evaluated relating to TP53 variant analysis and reporting.
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PMC9429973
Summary/Conclusion: The information generated by this study will help to better understand the clonal evolution of FLT3 throughout the course of the disease for AML patients.
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PMC11745600
Fifteen-week-old wt, Ins1, and Ins1 mice were used in the immunohistochemical analysis.
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PMC11687167
In addition, apoptosis might be involved in the underlying pathogenetic mechanism in the existing studies of PCSK9 and tumorigenesis.
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PMC10870498
One-way analysis of variance (ANOVA) was used for comparison among groups.
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PMC8526701
E WT and PUMA-KO GIST-882 cells were treated with 0.5 μM GSK602 for 24 h. Apoptosis was analyzed by fragment nuclei assay.
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PMC9429973
Image: Summary/Conclusion: Even if prematurely interrupted, our study demonstrated no meaningful difference in efficacy between ASCT and RIT, but ASCT was more toxic and more demanding for pts and health service.
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PMC8557138
For instance, various studies have shown growth and maturation of tumor endothelial cells that are influenced by mechanical stress on the inner vessel wall and extravascular mechanical stress (Egginton et al. 1998; Shiu et al. 2005; Giverso and Ciarletta 2016).
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PMC11772449
After completing the cell CCK-8 experiment, the results of the CCK-8 experiment were filled in according to the Excel template provided by the website (https://synergyfinder.fimm.fi/).
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PMC7039683
The average density of ATAC-seq reads was slightly higher in H3K27Ac vs. H3K27Ac cluster (Figure 5—figure supplement 1B).
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PMC11407042
Extend the incubation time if digestion is incomplete, but not exceed 5 min.e.
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PMC11585587
Extracted primarily from Anemone raddeana regel, Raddeanin A (RA) is a natural triterpenoid saponin compound with anti-inflammatory and anti-tumor activities.
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PMC9429973
Mean (SD) Hb increase from BL to Wk 60 (α-thalassemia, n=4; β-thalassemia, n=9) and Wk 72 (β-thalassemia, n=8) were 1.5 (0.4) and 1.7 (0.5) g/dL, respectively.
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PMC11751675
The antiviral activity of 13-acetyl solstitialin A (6) (16–0.00006 μg mL) toward the DNA virus HSV-1 was as potent as reference drug, acyclovir with minimum nontoxic concentration (MNTC) of 16 μg mL. Centaurepensin (7) and chlorojanerin (8) with MNTC of 2 μg mL were active against the DNA virus HSV-1 and were less active than 13-acetyl solstitialin A. All three sesquiterpene lactones were totally inactive against RNA virus (PIV).
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PMC10955424
A significant number of metabolites (Table S1) were found to be enriched in malignant ascites in comparison to cirrhosis ascites.
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PMC11566417
The secretome from primary and immortalized MDECs, at low and high passages exerted immunomodulatory effects on neutrophils in vitro.
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PMC9429973
Based on these promising results GC012F is being studied in earlier lines of therapy as well as additional indications.
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PMC10847511
Using all SNVs extracted from gene mutation profiles as input, the cosine similarity to the mutational signature 3 of COSMIC version 2 reference signatures was calculated using SigMA.
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PMC11762280
The primary antibody against ZBP1 (#13285-1-AP for human) was from Proteintech (Rosemont, IL, USA).
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PMC11323699
Plasma TSP-1 concentration was quantified using an ELISA assay.
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PMC9780037
In pharmacology, the IC50 parameter corresponds to the drug concentration that induces 50% of its maximum response.
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PMC4355729
The important discovery of our study is that PIK3R1 is down expressed in RCC, especially in advanced and metastatic RCC.
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PMC11711663
The log-rank test shows significant results for race and drinking status at PFS12, PFS24, PFS48, and PFS60.
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PMC10671321
We thus wondered if these hallmarks were also present in human muscle cells and if the distal ColQ C-terminus was involved in these molecular phenotypes.
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PMC11525293
Among these, the usage of the immunomodulatory drug Thal was proposed, and its administration proved effective in fastening patient recovery and reducing the levels of inflammatory cytokines in the serum of the patients .
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PMC9429973
Yiwu, Zhejiang, Peoples R China.
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PMC11300639
786-O (SC0154) cells were purchased from the Yuchicell Biology Technology (Shanghai, China) and identified by STR profiling.
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PMC8751435
As results show, overall membrane GSDME expression is slightly increased, whereas individual expression is remarkably enhanced in specific single cell.
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PMC10759659
P < 0.05, ** P < 0.01, *** P < 0.001) ARID1A deficiency was associated with elevated immune checkpoint expression and upregulated Galectin-9 expression.
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PMC11473750
h A graphical representation showing RNF121 protein expression levels in tumour tissues from TH-MYCN mice crossed with either RNF121 or floxed RNF121 knockout mice, across 5 independent western Blots (each with 3 different tumour lysates per group).
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PMC9429973
The ASCEND trial compared acalabrutinib with investigator’s choice chemotherapy, either idelalisib plus rituximab or bendamustine plus rituximab.
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PMC11767582
Fetal bovine serum (FBS) was a product of Harlan-Seralab (Belton, UK).
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PMC9429973
Alterations in BMSCs contribute to several disease states, including acute myeloid leukemia (AML) and other hematologic cancers.
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PMC11732628
Patients with osteosarcoma are prone to lung metastasis and death (2).
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PMC10538569
Cells were then washed twice with PBS and 5×10 CEMss-GPI GFP cells in 300 µl of FluoroBrite DMEM were co-cultured with iDCs.
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PMC11678841
Disrupting this balance can promote its overgrowth and the transition from yeast to hyphal form, which plays a crucial role in the pathogenesis of VVC .
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PMC11515150
Cytotoxicity of 12 C CAR-NK cells and NT-NK cells against CD5 hematologic malignant cells was evaluated.
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PMC10452486
However, the B2m-specific polyclonal Abs did not affect such binding of insulin receptor to HLA, which suggests that the cell surface HLA HCs can independently serve as ligands without the involvement of B2m. This finding initiated the study of “empty HLA” molecules (peptide-free and B2m-free) now referred to as open conformers by Arosa et al. .
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PMC4443654
In reciprocal crosses between the two hematopoietic cell lines (K562 and GM12878), this loss of accuracy was between 5.9% and 7.8% (Figure 3A), but was 20.2% to 20.4% when these models were applied to H1 hESC data.
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PMC11126803
For (B–G), quantitation is on the right.
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PMC8345486
Unfortunately, AP-1 and Nf-κB are upregulated in tumors and directly correlate with the cancer cell proliferation rate and their chemoresistance .
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PMC9429973
Clever-1 (STAB1) is a scavenger receptor, expressed on the surface of a subpopulation of immunosuppressive macrophages.
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PMC11802855
All patients received an initial treatment of a three-drug combination of protease inhibitor, lenalidomide, and dexamethasone.
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PMC11533140
As shown in Table 1, the inhibitory activities of compounds 12a–12f were poor, and Table 2 shows that some compounds (17e, 17m, 17o, and 17p) had strong inhibitory activity against PI3Kα kinase (IC50: 104.1–32.4 nM).
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PMC10506676
Also, c-MYC protein is able to bind to the promoter region of vascular endothelial growth factor A (VEGFA) to stimulate more production of this growth factor and then cause angiogenesis (41).
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PMC11469524
Interestingly this PI3Ki counter-regulation is much more prominent for α-IgM down-regulated sites (23%) than for α-IgM upregulated sites (3%).
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PMC9429973
In the 12 HS patients, variants were heterozygous, consistent with the predominantly dominant inheritance.
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PMC10154881
The viral titer was determined at the indicated time points.
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PMC11291490
The collected sera were subjected to inactivation at 56 °C for 30 min and then were serially diluted in twofold increments (2–2) using DMEM.
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PMC11742231
Adaptive fusion can also be used to reduce overfitting by combining multiple sources of information into one output.
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PMC4659567
Calcd.
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PMC11015054
These results suggest METTL5 significantly affects HCC patient prognosis and may have higher validity for predicting HCC prognosis.
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PMC11240052
To do this process, 1.5 × 105 cells/well were plated in 6-multiwell plates with or without 50 µM metformin.
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PMC9221284
The resulting proteins contain the same carboxy-terminal domain but differ in their N-terminal regions.
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PMC10631132
As expected, an abundance of ALP negative cells was observed following hematopoietic differentiation in both differentiation protocols (empty arrows in Fig. 2D,F,J,L).Fig.
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PMC11541409
However, this strategy has not been investigated for GIST, unlike in the cases of BTK, EGFR and HER2 where covalent TKIs are approved for therapy [35–37].
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