Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC8143558
It may be that there is an assumption that hand and toilet soap are accessible to everyone in the world.
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PMC8540692
Human GBM cell lines, A-172 and U-138 MG were obtained from American Type Culture Collection (ATCC), whereas human GBM T98G cell line was bought from the European Collection of Authenticated Cell Cultures (ECACC).
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PMC11462673
Despite significant progress in the prognosis of pediatric T-cell acute lymphoblastic leukemia (T-ALL) in recent decades, a notable portion of children still confronts challenges such as treatment resistance and recurrence, leading to limited options and a poor prognosis.
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PMC11794588
Applying crushed leaves straight to cuts and wounds speeds up the healing process.
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PMC8806312
These data indicated that high risk group can affect immune cell infiltration signatures.
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PMC9429973
MBL, ISFN and MGUS may be detected decades prior to overt malignancy.
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PMC11529598
Cells were washed before photographed under a microscope (Olympus, Tokyo, Japan) and cell number is expressed as the average number of cells per visual field.
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PMC10507284
After identifying the differential genes, we further carried out univariate regression analysis to screen the genes relevant to prognosis.
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PMC11409031
With the accumulation of multi omics data and optimization of algorithms, OV research is entering a data-driven new era.
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PMC11462673
Survival curve analysis was compared by Log-Rank test, and P < 0.05 indicate statistical significance.
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PMC11310713
The alginate solution, containing 5 × 10 GCs, was dropped from the needle into a 1% calcium chloride (Sigma-Aldrich) solution.
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PMC11655498
The host SMC5/6 complex recognizes and occupies R-loops, which are essential for DNA double-strand separation and the loading of core replication proteins during the lytic cycle, inhibiting the synthesis of EBV genome (Yiu et al., 2022).
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PMC11462673
A CCK-8 assays detected the effects of MBZ.
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PMC11400680
Subsequently, these generated box prompts are fed into the SAM.
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PMC11775197
It has been proven that the transcription factor MYC inversely regulates the expression of genes in the WNT signaling pathway.
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PMC10747139
The dual drug delivery system was studied via in vitro tests using MDA-MB-231 breast cancer cells, and it was observed that RAPTA-C, in combination with paclitaxel, significantly enhanced antitumor and antimetastatic action .
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PMC11696659
The results of this study suggest that TAV analysis in peripheral lymphocytes can be considered a useful diagnostic tool during screening for lung cancer in high-risk patients.
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PMC9429973
The myelosuppression observed with HU treatment was mostly transient in nature but required regular monitoring which can be challenging in LMICs.
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PMC11659921
CDF curve and cluster heatmap analyses indicated that optimal grouping was achieved by dividing the samples into two clusters (Figure 3A,B).
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PMC11541241
In numerous studies, the plant TOR pathway is inferred as a vital switch from growth to defence to pathogens (Henriques et al., 2022; Margalha et al., 2019).
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PMC10900886
Enterovirus D68 (EV-D68) is predominantly associated with mild respiratory infections, but can also cause severe respiratory disease and extra-respiratory complications, including acute flaccid myelitis.
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PMC11185260
BT-12 and A-204 cells were plated in six-well plates at a density of 1.0×10 cells per well and transfected with either scL-vec or scL-SMARCB1 nanocomplexes as described above.
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PMC11678448
We conducted this enrichment analysis using the KEGG database (Release 101).
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PMC11143482
In addition to that, decrease in body weight might be attributed to complication during cancer cells development in the mice.
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PMC11701801
First, we assessed whether synthetic lethality in SMARCA4/SMARCA2-deficient cells and SS18–SSX fusion cells caused by suppression of CBP/p300 could be prevented by depleting KREMEN1.
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PMC11727638
Since the 2D culture system cannot effectively replicate the environment that induces multidrug resistance , drug resistance to DOX in cells cultured in the Cell Domes reflects the characteristics of the in vivo lymphoma microenvironment.
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PMC8557138
For example, Wang et al. using organoids of hepatocellular carcinoma cells cultured with endothelial cells and fibroblasts revealed the expression of EMT markers including vimentin, TGF-β, and MMP9, neoangiogenesis markers such as VEGFR2, HIF-1α, and VEGF, inflammatory markers such as CXCL12, CXCR4, and TNFα to be upregulated in these organoids (Wang et al. 2017).
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PMC10366908
Therefore, we developed the RIEDL insertion for epitope mapping (REMAP) method to identify the conformational epitope.
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PMC11413393
d Mean fold-change values (± SEM, n = 3 technical replicates) in the percentage of GFP+ cells, relative to the percentage of GFP+ cells at passage 0 in cell lines RCC364 and 786-0 for PRMT1 and control sgRNAs.
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PMC11718817
Multiple studies found evidence that T cell motility is associated with tumor progression .
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PMC11190062
Next, cells were stained with Alexa Fluor 488 Anti-BrdU (#ab220074, Abcam) for 1 hour at room temperature.
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PMC11802855
Osteolytic lesions and pathological fractures are hallmark manifestations of multiple myeloma (MM), profoundly influencing the quality of life and self-care ability of MM patients.
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PMC11591038
It was found that P301L mice have significantly less HIF-1α with more severe total protein oxidation than wild-type controls, whereas the intranasal delivery of DFO significantly reversed these differences; however, no significant decrease in phosphorylated tau was observed in the brains of these DFO-treated mice, at least for the brain regions examined .
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PMC5035325
Results were evaluated by the intensity of immunoreactions and the percentage (%) of the tumor cells displaying immunoreactivity with the cytoplasm and on the membrane pattern.
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PMC11704834
In addition, some patients with EGFR-TK mutations do not respond to EGFR-TKIs (intrinsic resistance) while others with wild type EGFR respond to this drug (3).
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PMC9429973
The BCL2 inhibitor, venetoclax, is standard of care for the treatment of newly diagnosed AML in adults unfit for induction chemotherapy.
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PMC11757131
The proliferation of PMECs is fundamental for mammary tissue development to ensure milk production.
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PMC9325715
Instead, the band at 1105 cm has appeared, which can be assigned to ν(CN) of histidine.
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PMC6600592
Similar structure-activity relationships were found in our previous works .
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PMC10040136
However, when a TGF-β2 monoclonal antibody was introduced into the conditioned medium, blocking the TGF-β2 signal, this effect was antagonized (Fig. 5A, B).Fig.
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PMC11365983
Statistical analysis in panels (B) and (C) shows data pooled for all shRNAs].
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PMC11515150
CD5-FL: Full-length CD5; CD5-Trunc: Membrane-proximal domain of CD5; VHH: Variable domain of heavy chain of heavy-chain Discovery and identification of anti-CD5 VHH. (
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PMC11474209
HRP-catalyzed ABTS oxidation product (ox-ABTS) quenched Si-CD fluorescence.7WaterLC-MS/MS andciELISAWater sample0.02–2.055 µg/LThe highly sensitive ciELISA detected nine MCs and NOD using MC-LR-keyhole limpet hemocyanin (KLH) for New Zealand white rabbit vaccination to produce antibodies.8Trampling Lake, Saskatchewan, Canada, and Pretzlaff Pond, Alberta, CanadaLC-HRMS/MS, 1 H and 13 C NMR spectroscopy, and UV spectroscopyCanadian cyanobacterial bloom sample-The data show that [D-Leu1]-containing MCs may be more common in cyanobacterial blooms than previously thought yet are overlooked by concentrated LC-MS/MS screening.9Saline water of continental salt marsh in the Malahá (Granada, Spain).UHPLC-DAD and UHPLC-MS/MSSALLE0.02–3.4 µg/LUHPLC-MS/MS and UHPLC-DAD have been used in conjunction with a SALLE10Treated water of the Municipality of Macapá, Amazon RiverLC-ESI-MS, ELISAWater sample0.026–2.1 µg/LIn this study, cyanotoxins and cyanobacteria were examined in samples taken from a drinking water treatment plant that uses the Amazon River.
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PMC11412752
STING is an endoplasmic reticulum (ER)-associated membrane protein known to trigger type I IFN and proinflammatory responses upon the detection of cytosolic DNA by cyclic GMP-AMP synthase (cGAS) .
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PMC11703992
In summary, our research identified two significant risk genes, DDIT4 and ARHGAP15, in GCA.
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PMC11727907
GR activity was assayed following the oxidation of NADPH with a spectrophotometric analysis at 340 nm.
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PMC11674441
At the time of publication, there have been no relapses or adverse events in the five breast cancer patients.
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PMC11286266
Of the three arms of the UPR, the mechanisms that govern ER stress-dependent ATF6 activation remain the least well understood, even though ATF6 mediates much of the ER-stress-induced changes in gene expression observed in vertebrates.
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PMC7171147
In recurrent ovarian tumors, CPT1A expression was positively correlated with COL11A1 expression (Fig. S7C).
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PMC11781181
In this study, TEN Exo treatment and miR-375-3p increased cellular oxidized PUFA (AA and DHA), phospholipids PE (18:0/20:4), (18:0/22:4) and (18:0/22:6), upregulated ACSL4, LPCAT3, and ALOX15 expression level.
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PMC10578720
Experimental data were presented as the mean± SD, and statistical analysis was carried out using GraphPad Prism 8 (GraphPad Software, CA).
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PMC11367146
The primer sequences used for the expression study are listed in Table 1.
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PMC11547972
Another investigation has revealed a synergistic effect of an amygdalin-vinblastine mixture on the proliferation of cervical cancer cell lines.
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PMC10674574
Although chlorpheniramine is recognized by regulatory authorities as a moderate permeable drug, the permeability data of this model compound require further investigation.
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PMC11700165
The next day, cells were transfected with plasmids and incubated for 48 h. Cells were fixed and permeabilized and immunofluorescence staining was performed as previously described.
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PMC11155445
XRD analysis posed that the title compound crystallized in a triclinic crystal system and adopted the P1̄ space group, carbonyl and thiocarbonyl tend to stay in opposite directions, and extensive delocalization was present at the acyl thiourea part of the molecule as indicated by the bond lengths, and crystal packing is due to intermolecular H-bonding among molecules (Fig. 29).
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PMC7823217
Although the bioprinted cancer models share a common 3D conformation, each display its own intrinsic properties.
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PMC11411131
The cDNA corresponding to amino acids 410–461 of odc (M10624) was synthesized by Fasmac.
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PMC11635519
Plasmid DNA was purified, and the library coverage, complexity, and fidelity were tested by using Sanger sequencing and Illumina deep sequencing.
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PMC11772585
The results showed a significant decrease in OCR across various parameters such as basal, ATP production, maximal respiration, and spare respiratory capacity, accompanied by an increase in ECAR including glycolysis, glycolytic capacity, and reserve capacity (Fig. 6A, B and Supplementary Fig. S7C–F).
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PMC11785489
We find that hydrophobic complementarity-determining region (CDR)3 residues promote regulatory T cell fates in both the CD8 and CD4 lineages.
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PMC11320084
Although the treatment of LC has developed from traditional chemotherapy and radiotherapy to the current stage of targeted therapy and immunotherapy, its efficacy is not ideal and can easily affect the life quality of patients. ,
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PMC11515150
Cytotoxicity of CD5 CAR-T cells against CD5 CCRF-CEM cells.
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PMC9429973
Image: Summary/Conclusion: Although the only curative treatment remains the allogeneic transplantation in MDS, therapies have become available with therapies available since 2015.
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PMC9429973
The 1- and 2-year overall survival(OS) in the CAR-T group and Chemo-DLI group were 68.2% vs 19%, 63.6%vs 9.5%, respectively.
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PMC9019892
In addition, many candidate KIT inhibitors are in preclinical development, such as CHMFL‐KIT‐033/8140 and AZD3229 .
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PMC11635087
CHO-K1 cells are highly receptive to exogenous substances, making them suitable for maintaining algal chloroplasts.
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PMC11507371
Following 2 h incubation, fluorescence (ex/em: 485/535 nm) was detected with a Tecan Infinite M200 Microplate Reader (Tecan group AG, Männedorf, Switzerland).
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PMC11641630
The plates were incubated at 37 °C with 5% CO2, monitored, and photographed using an inverted microscopy Axio Observer A1 (Zeiss, Oberkochen, Germany) at different time points: 0, 12, and 24 h. The wound-healing area was calculated as the percentage area of the initial wound with respect to the percentage area of wound closure at 24 h using the ImageJ ver.2.0.0 software and the MRI Wound Healing Tool macro (http://dev.mri.cnrs.fr/projects/imagej-macros/wiki/Wound_Healing_Tool (accessed on 1 October 2022)) .
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PMC10907726
Total RNA were purification, library construction, and sequencing according to the manufacturer's instructions (Illumina, CA) in Majorbio Bio-pharm Biotechnology (China).
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PMC9429973
The phenotype could be established through the most significant hematological parameters 1) hemoglobin levels, 2) MCV, 3) RDW and 4) the percentage of Hb F. But molecular diagnosis and genetic counseling should continue to be used because, although the heritability of a triplication of alpha genes, in many cases underdiagnosed, does not present clinical complications, it can be inherited with another pathology such as heterozygous β-thalassemia and aggravate the clinical picture.
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PMC9429973
Methods: The UK National External Quality Assessment Service for Leucocyte Immunophenotyping has provided external quality assessment for use of NGS gene panels in CLL since 2018.
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PMC11490153
Other peaks in citral and AlgNPs confirmed the successful loading of citral in the prepared citral-AlgNPs.
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PMC11627133
The SMLM image was reconstructed from 3000 frames.
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PMC11365983
Representative images of Arl13b/γ-tubulin staining in primary meningeal cell cultures from Foxc1Tg(EIIa-cre) and wild-type sibling E15.5 embryos.
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PMC9429973
This observation is certainly intriguing, however inherently limited due to the low-sensitive, Sanger-based approach used for the immunogenetic characterization.
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PMC8270637
The results of flow cytometry showed that the apoptosis of T cells treated with TGF-β1 and subsequently co-cultured with HCC cells was significantly increased.
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PMC11622247
Of note, introduction of the QB dye in C1-AF568-QB rendered emission from AF568 responsive to hybridization, as shown by the low fluorescence of the single stranded probe (Fig. 3D).
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PMC11555465
In five random fields of view, the numbers of cells that had migrated/invaded were observed under an inverted light microscope (magnification, ×200) and images captured and quantified.
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PMC11024707
Future studies should investigate this subject.
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PMC11549612
In our study, the TISIDB database played a pivotal role in dissecting the expression patterns of BOLA genes across diverse immune and molecular subtypes of KIRC.
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PMC11367146
TNF-α, IL-1 and IL-6 antagonists show promising therapeutic effects, yet they make the body more prone to inflammation and induces tumour-related diseases .
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PMC11371747
Additional details and sources of cell lines are described in (Jansen et al., 1990; 1997; Van Triest et al., 1999; Backus et al., 2000; Cillessen et al., 2008; Giovannetti et al., 2008; 2017; Lasry et al., 2008; Lemos et al., 2008; Lemos et al., 2009).
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PMC5173112
Membranes were blocked with 5% milk for 1 hour and incubated with primary antibodies overnight, including anti-USP21 antibody (Santa Cruz, 1:1000), anti-IL-8 antibody (Abcam 1:1000).
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PMC6461034
To date, only about two‐thirds of the kinome has been covered, and more substantial inferences could be made with further population of resources (such as PhosphoSitePlus), especially when the latter also cover cancer‐associated aberrations such as fusion gene products BCR‐ABL and EML4‐ALK (Medves & Demoulin, 2012; Lee et al, 2017).
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PMC11759543
Effect of Z-VAD-FMK on the combined drug-induced apoptosis-related protein expression.
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PMC9429973
However, the visual analysis of 18F-FDG diffuse bone marrow uptake in detecting bone marrow involvement (BMI) in routine clinical practice is still challenging.
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PMC8633974
Agarose gel electrophoresis of PCR product showed in both U1 cells (e) and JLat cells (f) full-length HIV was present in untreated cells but not treated cells.
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PMC11247842
Interestingly, in a study of alternative splicing associated with mastitis , one of the LTF- isoforms (Lactoferrin_10) was one of the most under-expressed isoforms in the mastitis samples compared to the healthy samples, which suggests that further analysing the expression of this gene may be important for revealing the mechanisms involved in the development of mastitis.
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PMC11723947
As the gene encoding SUV39h1 is carried on the X chromosome, Suv39h1 males were crossed with heterozygous Suv39h1 females to obtain both Suv39h1 and Suv39h1 males within the same litter.
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PMC9429973
The production of IFNg producing T-, CIK and NKT-cells was demonstrated, suggesting an in vivo production/activation of (potentially leukemia-specific) cells.
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PMC11224020
A maximum z projection is shown; scale bar, 10 µm.
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PMC11568601
B The expression levels of proteins involved the regulation of ER stress, including ATF6, BiP, p-IRE1, XBP1s and CHOP, were significantly decreased according to western blot analysis.
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PMC11335267
Gene expression analysis demonstrates altered lipogenic and lipolytic gene profiles.
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PMC11747949
We chose 143B cell and healthy donor PBMC coculture method as it better reflects in vivo cell behaviors and has emerged as an important method with various applications in cancer research (Oda et al. 2021; Rasouli and Safari 2024).
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PMC9596868
I-J) Percentage cell viability of A2780cisR and HCT116 cells, respectively, after treatment with quercetin at various concentrations. (
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PMC11545737
Other members of the genus are the commensals N. lactamica, N. mucosa, N. sicca, N. subflava, N. cinerea, N. elongata and N. flavescens.
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PMC10588957
Currently, the majority of alterations in HCC remain undruggable (4).
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PMC9429973
Three vaso-occlusive crises (grades 2 and 3) occurred in 2 patients and were deemed unrelated to GBT021601.
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PMC5173112
Representative images of sphere formation assay in 786-O and A-704 cells.
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