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PMC9429973
Results: A decreased frequency of all NK cell subsets was found in AML (CD56, P=0.03; CD56, P=0.04, CD56, P<0.01).
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PMC11673128
In contrast, blocking CD47 on normal cells would trigger no phagocytosis due to the absence of positive “eat me” signals .
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PMC6114978
Statistical significance determined by two-tailed t-test.
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PMC10523483
Statistical analyses were performed using GraphPad Prism unless indicated otherwise.
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PMC9429973
Our data suggest that the early bone marrow T cell signature post alloSCT might reflect GVL-effects required to achieve long-term survival.
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PMC11539788
Cell proliferation was assessed by performing cell counting kit-8 (CCK-8) and colony formation assays.
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PMC9341513
We considered whether these changes could be predicted from the simulated structures.
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PMC11468365
Then, the drug features were merged with the cell line features and input to a deep learning model.
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PMC11632064
One important observation of our study is that specific inhibition of RSK does not typically induce CXCL8 and has a mild impact on proliferation.
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PMC10565698
We verified miR-211-5p expression using qRT-PCR and found it downregulated in 32 pairs of LC tissues (Fig. 4H).
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PMC11583690
Loading capacity based on DTX concentration. (
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PMC9592219
The statistical significance between two groups was analyzed using Student's t-test.
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PMC9429973
R. Moia, C. Favini, D. Talotta, S. Sagiraju, R. Bruna, R. Dondolin, I. Della Starza, R. Soscia, A. Andorno, F. Mercalli, C. Deambrogi, S. Rasi, L. Petrucci, T. Bellissimo, R. Luciano Boldorini, A. Di Rocco, I. Del Giudice, M. Martelli, R. Foà, G. Gaidano Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara; Division of Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome; Division of Pathology, Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy Background: Diffuse large B-cell lymphoma (DLBCL) displays a high degree of molecular heterogeneity and may be classified into molecular clusters harboring specific lesions and therapeutic vulnerabilities.
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PMC10568263
An organic monolayer via the self-assembly of LC was formed on the surface of the Au@MnO2/MoO3/SPEs because of the strong specific interaction between the Au surface and the sulfur atoms.
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PMC11640247
Dunnett’s or Tukey’s test was used to determine statistical significance for multiple group comparisons, while Welch’s t-test was used for two-group comparisons.
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PMC11721277
The target compound was isolated via column chromatography on a silica gel (n-hexane/ethyl acetate 1/1 v/v).
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PMC11209164
Additionally, TPF was used to pre-treat other cancer cell lines, such as MC38, 4T1, and B16-OVA, and we observed a similar increase in GFP transgene expression following VSVΔ51 infection, as demonstrated in (Figure S2).
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PMC11719944
However, this group tends to increase cellular levels concerning the diagnosis time.
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PMC11564322
Both the VGVAPG peptide and the c-SRC inhibitor I decreased the ERK 1/2 kinase protein expression by 33.81 and 65.85%, respectively, compared to the control (Fig. 6F).
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PMC11683240
After that, the incubation with primary antibodies for PTS1 (anti-PTS1, clone 63.1G9, sc-57639, Santa Cruz) and α1AT (Alpha-1-Antitrypsin antibody, Proteintech, Planegg-Martinsried) in blocking solution was performed for 1 h at 37 °C.
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PMC11409031
Displays the relationship between risk scores and immune cell presence. (
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PMC11564405
Examination of the IHC images demonstrated the cytoplasmic localization of the RILPL2 protein (Fig. 1A).
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PMC9429973
A limitation of a MAIC is that bias due to potential unmeasured differences in patient baseline characteristics between trials cannot be excluded.
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PMC11634794
Knockdown of LC3C resulted in decreased expression of LAMP1, suggesting that LAMP1 may function as a downstream target of LC3C.
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PMC11638288
Furthermore, the binding sites of NKp46 to its ligands have yet to be clearly defined.
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PMC5673060
Fig. 1 Experimental outline and phosphoprotome dataset overview. (
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PMC10840195
Then, the samples were denatured at 100 °C for 5 min, and 50 µl of sample was loaded onto an SDS‒PAGE gel (4–20% Mini-Protean® TGX Stain-Free™; Bio-Rad Laboratories, Inc.).
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PMC9325715
The analyses were performed in triplicates.
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PMC10158546
Prions are misfolded proteins that accumulate within the brain in association with a rare group of fatal and infectious neurological disorders in humans and animals.
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PMC11194678
Whether STAU1 overabundance is an accompanied result of aberrant autophagy or it actively participates in the development of various neurodegenerative diseases (with unknown mechanisms) is an open question.
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PMC11143482
However, its establishment and application still face many challenges.
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PMC11569208
Processing by KALLISTO pseudo-alignment and SLEUTH yielded normalized log2-fold change in differential gene expression and P-values. (
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PMC10698968
for 30 minutes at RT and stained for 30 minutes in the dark with 100 µl of 1% methylene blue solution in 0.01 M borate buffer pH 8.5.
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PMC6163708
These cells were also completely resistant in the proliferation assay (Figure 2).
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PMC11745600
Next, we performed a histological analysis of islets to determine whether the pancreatic β cells of Ins1 mice were depleted, similar to the observations in Akita mice (Figure 3A–L; Figure S3, SDC, http://links.lww.com/TP/D122).
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PMC10203589
In 2011, Christine’s team found by qRT-PCR that the mRNA level of FGF18 was significantly increased in HCC relative to normal liver tissue (76).
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PMC11705630
ACHN and Caki-2 cells were maintained in DMEM high glucose medium (WELLGENE, Gyeongsangbuk-do, Republic of Korea).
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PMC10243817
Immunofluorescence staining of submerged cultured HNECs was performed as previously described with minor modifications (52).
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PMC10900886
In intranasally inoculated ferrets, virus was detected in axillary lymph nodes at multiple days post-inoculation (earliest detection at day five post-inoculation) (13).
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PMC11012313
Membranes were then blocked for one hour using 1% casein in tris-buffered saline (TBS), followed by overnight incubation at 4 °C with (1:1000) anti-phospho-p70 S6 Kinase (Thr389) or anti-p70 S6 Kinase (Cell Signaling Technologies) antibodies.
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PMC9341513
For FISH microscopy, briefly, fosmid clones found to cover TPCN2 (G248P87917D11/WI2-1721H21), MYEOV (G248P87014D2/WI2-2222G4), and CCND1 (G248P86668E2/WI2-2191I3) loci were obtained from BACPAC resources.
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PMC11538390
We conducted a genome-wide association study in the Finnish population and identified rs570516915, a single nucleotide polymorphism highly enriched in Finns, as strongly associated with CP (P = 5.25 × 10, OR = 8.65, 95% CI 6.11–12.25), but not with CL/P (P = 7.2 × 10), with genome-wide significance.
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PMC11644761
After 24 h of treatment, pterostilbene at both concentrations induced global hypomethylation in replicative cells.
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PMC11748335
We aggregated the -log10(q-value) for each GO term across all samples and all three peak types, presenting the top 20 terms with the highest sum (Fig. 1C).
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PMC8170755
Furthermore, VPA-treated A549 cells showed decreased expression of CD44v6, MMP-2, and MMP-9 considered as metastasis indicators in cancer.
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PMC10932641
Compared with that of the blank control group, the expression of N-cadherin and E-cadherin protein related to the invasion and migration in the negative control group was not significantly different (P>0.05); compared with that of the negative control group, the expression of N-cadherin protein in the siGPRC5D-AS1 group was significantly increased (P<0.05) while the expression of E-cadherin protein was significantly decreased (P<0.05); compared with that of the negative control group, the expression of N-cadherin protein in the oeGPRC5D-AS1 group was significantly decreased (P<0.05) while the expression of E-cadherin protein was significantly increased (P<0.05) (Figures 8,9).
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PMC9635307
Therefore, primary B cells were stained with anti-Igμ F(ab’)2 fragment and CC1 before and after the BCR stimulation in order to observe expression of these molecules in the cells.
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PMC11469524
In summary, the BL-2 model constitutes a generic network structure that can accurately describe signaling for both BL cell lines.
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PMC11544122
Future studies are required to investigate this possibility.
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PMC11306331
We only observed a significant change in both metrics for MBP and mCherry recruitment, with a larger magnitude of effect for MBP (Fig. 1C, D), results that are consistent with our qualitative observations (Fig. 1B).
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PMC11648299
The DD diagnoses of the local cohort were also used to validate DD diagnoses recorded in the NPR for patients visiting the SUH, as previously described .
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PMC8316344
Fig. 7TRIB2 exclusively regulates RSL3- and erastin-induced ferroptosis independent of GPX4 and the schematic presentation of the study.
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PMC11721295
As observed in the L-iKRAS model, upon inhibition of oncogenic KRAS, phosphorylation of STAT decreased (Supplemental Figure 6F).
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PMC11283030
Huayu Gao: Software.
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PMC10040136
In the contact co-culture system, MSC and GIST cells are cultured together in the same dish.
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PMC10587429
D-Luciferin, Potassium Salt (LUCK-1G, Gold Biotechnology, Olivette, MO). -
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PMC9429973
Methods: We retrospectively evaluated data records from 482 patients that underwent ASCT from January 2011 until October 2021 in our Institute.
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PMC9429973
Overall, 9 out of 15 (60%) patients achieved a response as assessed by the treating physician, with 6 complete responses and 3 partial responses.
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PMC10900886
Susceptibility and permissiveness of human PBMC to EV-D68 infection. (
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PMC10761218
The IC50 values of W. somnifera leaf, stem, and root methanolic extracts in HepG2 cells were found to be 43.06 μg/mL, 45.60 μg/mL, and 314.4 μg/mL (Figure 4), and L929 78.77 μg/mL, 90.55 μg/mL, and 361.70 μg/mL (Figure 5), respectively.
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PMC10652261
This outcome confirms the importance of the position of the fluoro group on the phenyl ring attached to the first position of the pyrazoline scaffold for antileukemic activity.
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PMC9429973
Median number of belamaf cycles were: Cohort 1 (6), Cohort 2 (3), Cohort 3 (3.5), Cohort 4 (4.5), and Cohort 5 (5).
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PMC11765988
Oxidative stress activates transcription factors such as NF-κB, AP-1, p53, HIF-1α, PPAR-γ, β-catenin/Wnt, and Nrf2, leading to the expression of over 500 genes related to growth factors, inflammatory cytokines, chemokines, cell cycle regulation, and anti-inflammatory responses .
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PMC10135767
These results indicated that the calcium signaling of RPMI 8226 triggered by the interplay of integrin α4β7 and MAdCAM-1 was positively regulated by wall shear stress, in which the external force could accelerate the bursting speed of calcium signaling and enhance the strength of calcium signaling.
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PMC11481779
The lower part of the chart presents the Pearson correlation coefficient, based on data from all chromosomes, the stratum-adjusted correlation coefficient (SCC) - calculated in similar way, and an average FID obtained by the models (the average is taken from the per-chromosome metric) In the upper part of the figure, an example output of the 3 models is presented - full HiCDiffusion, HiCDiffusion - only encoder and decoder, and C.Origami (version with epigenetics and sequence, and version with only sequence), along with the real Hi-C matrix.
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PMC9429973
Median age: 67 yrs (range 33-84); 77% male; median # prior tx: 1 (range 1-6); 25% del(17p) or TP53 mut; 27% del(11q); 50% unmutated IGHV; 27% bulky LAD (nodes ≥5 cm).
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PMC9436459
Next, the preparation of 2-arylbenzofuran iodides (S174 and S179) were achieved by coupling phosphonium salts (S173 and S178) with acyl chlorides (S171 and the resultant of acylation of S177 with oxalyl chloride) followed by intramolecular Wittig reaction.
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PMC9429973
But recently, more studies have revealed a hidden intrinsic therapeutic effect of ferumoxytol on tumors, but the role and mechanism in DLBCL has not been reported yet.
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PMC11748363
TB also remains the 13th leading cause of death and the primary cause of death in HIV‐positive individuals (World Health Organization 2022).
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PMC11574271
Consistently with these findings, we observed that increased RON expression by J82 cells results in enhanced invasive activities in vitro (Fig. 1I).
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PMC11402217
In contrast, the XD23 groups maintained their body weight more effectively (Figure 5C).
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PMC10253553
Real-time PCR was conducted with StepOnePlus (Applied Biosystems) and SYBR Green master mix (Applied Biosystems) in accordance with the suppliers’ protocols.
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PMC11612315
Under temporal anesthesia with 3% isoflurane, the CFA-induced inflammatory pain model was established via the intraplantar injection of 20 μL of CFA.
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PMC5025404
Therefore, the aim of this study was to obtain a stable cell line producing a mAb for a TNF-α blocker and to characterize the purified antibody in comparison with the drug Humira (AbbVie, USA).
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PMC11306331
Box plots show median, hinges represent 25 and 75 percentiles; whiskers represent 1.5x inter-quartile range (IQR).
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PMC11463018
1 5 1 ∼ 153 °C.
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PMC4839679
Validating relative expression of genes regulating primary metabolic processes (identified in RNA_seq data) in Caki2+Vectorand Caki2+PBRM1 cells by qRTPCR. (
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PMC10605143
Cells were fixed with 4% paraformaldehyde, permeabilized with 0.5% Triton X-100 for 10 min at room temperature, washed with PBS containing 100 mM glycine and blocked using 10% normal goat serum (Abcam) in a buffer containing 0.1% bovine serum albumin (BSA, Sigma-Aldrich), 0.2% Triton X-100 and 0.05% Tween-20 for 1 h at room temperature.
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PMC11678130
In this context, it was further investigated whether the A375 cell death triggered by the QUE + 5-FU treatment is apoptosis by verifying the aspects of the cell nuclei and cytoskeletal tubulin and F-actin filaments, as illustrated in Figure 5.
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PMC11718109
Fluorescence image of endogenous tdTomato-tagged TH DA neurons (white) plated on one side of the chamber (C), with a representative axon migrating through a microfluidic channel (D).
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PMC8382973
A standard curve was generated for each cytokine.
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PMC11530949
Across all evaluated concentrations, the biosynthesized Ag-doped CuO NPs and the chemically synthesized Ag-doped CuO NPs exhibited significantly higher cytotoxic effects than that of the Ephedra intermedia extract.
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PMC11470999
We reported here that VHL is the E3 ligase for CIP2A in melanoma.
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PMC11699042
P5 and P7 sites were exchanged to allow sequencing of the cDNA in read1 and barcodes and UMIs in read2 to achieve better cluster recognition.
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PMC11537649
Incubate at 37 °C for another hour and detect the absorbance value of OD450 nm using a microplate reader (ELx800, BioTek Inc., Santa Clara, CA).
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PMC11723210
This emphasizes the accuracy and reliability of the BPR method in QPI.
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PMC11711063
The detected changes were commensurate with significant downregulation of the mRNA and protein levels of ZG16B.
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PMC11670407
The cells were rinsed with PBS and then treated with 10 μM MitoSOX Red (HY-D1055, MCE) and kept at 37 °C for 30 min away from light.
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PMC11629192
Patient 4: An 11-year-old female exhibited anti-NMDAR encephalitis with frequent seizure (focal seizures occurring every 10–20 minutes and generalized), consciousness disturbance, severe insomnia, agitation, behavioural changes, a decrease of verbal output, dyskinesias, dystonia and urinary and bowel disorders requiring an indwelling urinary catheter.
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PMC10808409
The treatment with O2 showed the highest proportion of cells in the late apoptotic stage (Table 5, Fig. 6).Table 4Cell cycle analysis of Caco-2 cells following the treatment with IC50 of O2 and FA.%G0-G1%S%G2/M%Pre-G1Control Caco-254.66 ± 2.8937.59 ± 1.987.75 ± 0.411.87 ± 0.1O249.43 ± 2.61*43.59 ± 2.31*6.98 ± 0.3718.36 ± 0.97*FA51.81 ± 2.7433.89 ± 1.79*14.3 ± 0.76*6.99 ± 0.37**Significance from Caco-2 cells (untreated) at P < 0.0001.Significance from O2 treatment at P < 0.0001.Figure 5Cell cycle analysis of Caco-2 (untreated) and treated with O2 & FA: (A) Histogram showing percentage of cell population in each phase of cell cycle analysis. (
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PMC6442998
The precise effectors of cilostazol action on YAP inactivation remain to be identified, e.g. by co-immunoprecipitation of PDE3A in presence of cilostazol to identify PDE3A interactors linked to the Hippo pathway upstream of YAP.
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PMC11127909
These results suggested that EFHD1 may inhibit mPTP opening by mainly interacting with ANT3.
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PMC11574271
Representative images were captured at a magnification of 40× (Scale bar 1 µm).
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PMC9587866
The toxic effects of 1,7-dihydroxy-3-methylanthracene-9.10-dione can harm the urinary bladder, kidney, stomach, and pituitary gland whereas Sorbifolin affects the urinary bladder, kidney, and stomach only.
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PMC10938336
H-bond donors).
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PMC11792888
Untreated cells represent 100% cell viability.
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PMC5415764
On the other hand, polymer-drug conjugates have extensively been employed as prodrugs and significantly reduced the intermolecular competition of drugs30.
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PMC7987994
Cells were passaged regularly using trypsin–EDTA solution (Sigma, T4049) which was stopped by addition of the medium with FBS with no subsequent centrifugation.
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PMC11694066
Additional method details are available in Supplementary information.
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PMC10854447
for C18H15N5O2: C, 64.86; H, 4.54; N, 21.01.
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