OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9429973	FFP did not differ according to the final level reached (≥3 or ≥4; both p>0.20).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FFP", "did", "not", "differ", "accordi...
PMC9429973	Methods: This study is an ongoing, prospective, open-label, multicenter, phase 2 study (ChiCTR2100043748).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "This", ...
PMC11188874	C, Effect of HDAC6 inhibitors on pan MHC-I (HLA-ABC) presentation on CD138 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", ",", "Effect", "of", "HDAC6", "inhibitors", ...
PMC11438317	These procedures were done as reported before .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "procedures", "were", "done", "as", "reported", "before", "." ] } ]
PMC11138140	Pathological hypertrophy often precedes the development of heart failure and other adverse cardiovascular events .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pathological", "hypertrophy", "often", "precedes", "the", "development", ...
PMC11655536	Cell were treated with HA at 10 μM for 48 h. D, E Lysotracker staining of RPMI-8226 (D) and U266 (E) after treated HA at 10 μM for 48 h. Right panel, mean fluorescence intensity statistics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "...
PMC11547972	A clinical trial recently investigated the impact of 500 μM (90 mg) SFN given daily to patients with advanced pancreatic cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ...
PMC11406030	3 times/week for 3 weeks (Figure 5C) resulted in a 24% and 35% tumor reduction for LMTK3BP #1 and #2, respectively, compared to the control (p = 0.006).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	T. A. Eyre, M. L. Wang, N. N. Shah, A. J. Alencar, J. N. Gerson, M. R. Patel, B. Fakhri, E. Vandenberghe, W. Jurczak, X. N. Tan, K. L. Lewis, T. Fenske, Y. Wang, C. C. Coombs, I. Flinn, D. Lewis, S. Le Gouill, M. Gandhi, C. Chay, M. L. Palomba, J. A. Woyach, J. M. Pagel, N. Lamanna, J. P. Sharman, D. J. Andorsky, J. B. Cohen, M. A. Barve, P. Ghia, M. Yin, P. L. Zinzani, C. Ujjani, Y. Koh, K. Izutsu, E. Lech-Maranda, J. Kherani, C. Tam, S. Sundaram, B. Nair, D. E. Tsai, M. Balbas, A. R. Mato, C. Y. Cheah Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Center, Oxford, United Kingdom; MD Anderson Cancer Center, Houston; Medical College of Wisconsin, Milwaukee; Sylvester Comprehensive Cancer Center, Miami; University of Pennsylvania, Philadelphia; Florida Cancer Specialists/Sarah Cannon Research Institute, Sarasota; University of California San Francisco, San Francisco, United States of America; Hope Directorate St. James Hospital, Dublin, Ireland; Maria Sklodowska-Curie National Research Institute of Oncology, Krakow, Poland; Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Australia; Division of Hematology, Mayo Clinic, Rochester; University of North Carolina at Chapel Hill, Chapel Hill; Sarah Cannon Research Institute, Nashville, United States of America; University Hospitals Plymouth NHS, Plymouth, United Kingdom; Service d’hématologie clinique du CHU de Nantes, INSERM CRCINA Nantes-Angers, NeXT Université de Nantes, Nantes, France; Virginia Cancer Specialists, Fairfax; Messino Cancer Centers, Asheville; Memorial Sloan Kettering Cancer Center, New York; The Ohio State University Comprehensive Cancer Center, Columbus; Loxo Oncology at Lilly, Stamford; Herbert Irving Comprehensive Cancer Center, Columbia University, New York; Willamette Valley Cancer Institute and Research Center, US Oncology Research; Rocky Mountain Cancer Centers, US Oncology Research, Eugene; Winship Cancer Institute, Emory University, Atlanta; Mary Crowley Cancer Research, Dallas, United States of America; Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy; Medicine III, LMU University Hospital, Munich, Germany; Institute of Hematology “Seràgnoli” University of Bologna, Bologna, Italy; Fred Hutchinson Cancer Research Center, Seattle, United States of America; Internal Medicine, Seoul National University Hospital, Seoul, South Korea; National Cancer Center Hospital, Tokyo, Japan; Institute of Hematology and Transfusion Medicine, Warsaw, Poland; Peter MacCallum Cancer Center, Royal Melbourne Hospital, and University of Melbourne, Melbourne, Australia; Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States of America Background: Covalent BTK inhibitors (BTKi) have transformed the management of mantle cell lymphoma (MCL), but these treatments are not curative and the majority of patients (pts) will require additional treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11271278	Based on H3K27ac HiChIP and ChIP-seq signal, we observed four enhancers e1-e4, upstream of FOXA1 on chromosome 14, hijacked to the ETV1 promoter in LNCaP and MDAPCA2B cells (Fig. 3A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11531744	Heatmap of the 243 IRGs expression profiles. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Heatmap", "of", "the", "243", "IRGs", "expression", "profiles", ".", "(" ] } ]
PMC10729469	To confirm migration and accumulation of Tregs to the brain, TCRAβ-Tregs or polyclonal Tregs were radiolabeled with F-fluorodeoxyglucose (F-FDG, Cardinal Health, Omaha, NE).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11422150	So we focused on the serum NO concentration to confirm that.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "So", "we", "focused", "on", "the", "serum", "NO", "concentration", "to", "confirm", ...
PMC11790971	d–f Balanced accuracies and impurity scores of all experiments are shown in the bar plots.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "–", "f", "Balanced", "accuracies", "an...
PMC11774251	Topical Tan-I alleviated key features of psoriatic symptoms in vivo, including epidermal hyperplasia and skin inflammation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Topical", "Tan-I", "alleviated", "key", "features...
PMC11449273	Our findings again suggest a role for plakoglobin in the modulation of S100A4 expression in both p53-WT and mutant (p53-175 and -273)- expressing cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10761218	The leaf methanolic extract was the most effective, followed by the stem methanolic extract in the HepG2 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "The", "leaf", "meth...
PMC11257988	Finally, RAS also activates the RALGDS protein, which is a guanine nucleotide exchange factor for MAPK and RAL and phospholipase C activation, leading to the transcription of multiple transcription factors, including ELK1 and activation protein 1 (AP1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11527437	For example, less than 5% of USA White and Black patients with pancreatic ductal adenocarcinoma (PDAC) would be eligible for TCR-T using the HLA-C*08:02–restricted KRAS G12D targeting TCRs of Leidner and colleagues (9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9985266	The procedure was as follows: predenaturation at 95 °C for 10 min, denaturation at 95 °C for 45 s, and methylation at 95 °C for 35 cycles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8414691	In the last two decades, it has been shown that mutations in genes encoding a variety of chromatin factors and epigenetic regulators, such as DNA or histone modifying enzymes and members of ATP-dependent chromatin remodeling complexes, are crucial players in human genetic diseases and cancer [1–4].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878562	Moreover, the inhibitor abolished VAL-wt-mediated migration of VAL-ko in response to CXCL12 ( Figure 6A ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "inhibitor", "abolished", ...
PMC9429973	Treatment was ongoing for 9 (50%) patients (Cohort 1, n=1; Cohort 2, n=8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "was", ...
PMC10988555	Therefore, analyzing the results obtained in Table 1 and Figure 7 it is possible to say that complexes 2–4 have higher activity and % of internalization at 37 °C due to the contribution of active and passive mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8170755	The extracted RNA was further purified using DNase I (Thermo Fisher Scientific Inc.) digestion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "extracted", "RNA", "was", "further", "purified"...
PMC11297139	Enriched motifs of the dysregulated cREs were identified by using HOMER findMotifsGenome knownResults with the parameters “-size given”.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enriched", "motifs", "of", ...
PMC11519583	In fact, the binding of Wnt5b and Wnt11 to Ror2 was increased in the presence of increasing amounts of Wnt11 or Wnt5b (Fig. 6c), indicating that cooperative binding of Wnt5b and Wnt11 to Ror2 might be attributable to their synergistic action.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11359735	Anopheles stephensi (Liston strain) mosquitoes were reared in the insectary at the Johns Hopkins Malaria Research Institute and infected with P. berghei ANKA strain as described previously (9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794568	Survival curve analysis further indicated that patients with low CRIP1 expression had poorer OS compared to those with high expression (Fig. 2D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11723210	Two representative subregions (yellow and blue boxes) contain one individual cell, magnified in Figure 3(a3,b3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "representative", "subregions", ...
PMC11451940	Our initial idea was to generate square-planar mixed-ligand ionic systems of the type [M(Lap)(N–N)]NO3, where M = Cu(ii) and Zn(ii), and N–N stands for a bidentate N-donor aromatic imine, with the aim to prepare systems with good solubility in water and possibility to influence the cell cycle of cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11075223	Except the above cultivars, Actaea purpurea , Actaea japonica, Cimicifuga simplex black cohosh and Actaea asiatica Hara are often used as counterfeits or fake products regionally due to its similarity in the plant appearance and efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11789597	Representative confocal microscope images showing the levels of TMRE (red) in MM1S cells expressing shNC or shCAV1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "confocal", "...
PMC11499381	For AF-647 and AF-568 analysis, the combined, log-transformed fluorescence intensity values were analyzed by repeated-measures one-way ANOVA with post-hoc Dunnett's test, comparing each condition to the WT receptor condition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7504302	Similarly, deregulated amplification of MYC gene (MYC proto-oncogene, bHLH transcription factor, chr location: 8q24), a genetic event that can be recapitulated in asbestos-induced MPMs of wild type murine models, has been reported in a small fraction of MPM cases (<5%) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11012313	After incubation, cells were washed using PBS by centrifuging at 1500 rpm for 5 min, followed by incubation with Zombie Violet™ Viability dye (Biolegend, San Diego, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721587	The resultant beads were further used as substrates for second round of kinase assay with CK1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resultant", "beads", "were", "further", "used",...
PMC9429973	The results were statistically analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "were", "statistically", "analyzed", "." ] } ]
PMC6835428	This is an important rate-limiting enzyme in both normal and tumor DNA biosynthesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "an", "important", "rate-limiting", "enzyme", "in", "both", ...
PMC11585994	Scale bar, 20 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "20", "μm", "." ] } ]
PMC9429973	The investigator-assessed overall response rate (ORR) was 75%, with median response duration of 21.4 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "investigator-assessed", "overall...
PMC9429973	To assess different sources of variance ANOVA of a 3x3x3 experiment evaluating marker expressions on different cell populations in the blood of healthy donors using Quantibrite-PE beads was performed addressing technical variation (day, instrument) and biological variation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10969097	In terms of in vivo and in vitro studies, the focus was on selecting those that investigated the use of mushroom extracts combined with anticancer therapies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7433824	Then the spots were reduced and alkylated with 10 mM DTT and 55 mM iodoacetamide, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", "the", "spots", "were", "reduced", "...
PMC6889484	To create vectors pA33G(DK) and pA3x3G(DK), the following fragments were joined by ligation in the same reading frame: the 5′ direct repeat of A3G-D128K (1 to 1,083 nt of A3G for the A33G(DK) vector and the same 1 to 1,083 nt plus three in-frame stop codons, TGA-TAA-TGA for the A3x3G(DK) vector); 3′ direct repeat of A3G-D128K (nt 184 to 1,152); and P2A fused to eYFP (lacking a start codon).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791478	The internalization of XB002 and its parental antibody 25A3 was assessed in the TF-expressing A431 tumor cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "The", "internalization", "of", "XB0...
PMC11721295	We next set up a cell culture system (Figure 5D), wherein cell lysates and conditioned media (CM) were collected from the different treatment groups, MRTX or Soto, to assess transcriptional activation and secretion of cytokines and growth factors modulated in our scRNA-seq data set upon KRAS activation (see Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8336407	Finally, our results showed that the groups treated with extract only but not t-BHP, had lower cell viability [E 1.5 mg/mL (p value = 0.016), E 2.0 mg/mL (p value ≤ 0.001), and E 2.5 mg/mL (P value ≤ 0.001)] when compared to the control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5261804	We are currently developing a PPI Portal website where PPI essentiality data, as well as data from our OncoPPi screening study , can be mined and viewed (A. Ivanov, B. Revennaugh, et al, manuscript in preparation).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767817	Notably, we demonstrated that the hypoxic conditions changed the pattern of affected proteins, including DKK-4, SIRT2, and p27, being downregulated compared to normoxic conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	i Percentages of different CD8 T cell subsets of transferred T cells in host blood.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "i", "Percentages", "of", "different", "CD8", "T", "cell", ...
PMC11805741	Peak numberTR (min)λ max (NM)[M + H] (m/z)Carotenoid IdentificatonFormulaCompound (%)15475851Antheraxanthin monoesterM-C18:011.725.8NDND--4.739.7470861.6Astaxanthin monoesterM-C18:123416.9NDND--12.2526458719.77Zeaxanthin monoesterM-C9:148.3ND: Not Detected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Peak", "numberTR", "(min)λ", "max", "(NM)[M", ...
PMC11588085	In both SKOV3-KRAB and OVCAR3-KRAB cell lines, SP was significantly enriched after XIST KDs: OVCAR3-KRAB cells showed a threefold increase in SP for both sgXIST7 and sgXIST9 (Fig. 2F); SKOV3-KRAB cells showed an 81-fold increase in SP for sgXIST7 and an 18-fold increase in SP for sgXIST9 (Fig. 2G).	[ { "tags": [ "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC6487404	Inhibition of the CYP3A4- catalyzed metabolism as well as the OATP1B1-mediated hepatic uptake of REG by cyclosporine was considered as the probable cause of the observed interaction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11026382	Gray pixels mark mutations with statistically insignificant epistasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gray", "pixels", "mark", "mutations", "with", "statistically", "insignificant", "epistasis", "." ] } ]
PMC9429973	At a median follow-up of 42 months (range, 2-106 months), the estimated 3 years PFS and OS for the entire population were 80% and 89%, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10040136	The proportion of MSC obtained using the FACS method in the other 50 samples was significantly correlated with progression-free survival (C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9895440	n = 12 donors of n = 6 experiments except for Teff n = 6 of n = 3 experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "12", "donors...
PMC8481254	In addition, WB assay results showed that O-GlcNAcylation and the expression of YAP and OGT were markedly inhibited in a dose-dependent manner by CA (Fig. 2H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711127	Recognition of the relevant Ag through the pMHC-TCR interaction in F-actin-dependent protrusions or microclusters initiates T cell activation (78).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recognition", "of", ...
PMC11754436	Further in vivo model studies are required to validate the findings presented here.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "in", "vivo", "model", "studies", "are", "required", "to", ...
PMC9429973	S. Aggarwal, S. Kumar, H. Topaloglu, A. Bela, O. Topaloglu Health Economics and Outcomes Research, NOVEL Health Strategies, Chevy Chase; Health Economics and Outcomes Research, NOVEL Health Strategies, Columbia; Systematic Literature Review Group, NOVEL Health Strategies, Chevy Chase, United States of America Background: Sickle cell disease (SCD) is a group of inherited red blood cell disorders.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9318744	Low-passage SARS-CoV-2 stocks were used in this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Low-passage", "SARS-CoV-2", "stocks", "were", "used", "in", "this", "study", "." ] } ]
PMC9596868	K-L) Percentage cell viability of A2780cisR and HCT116 cells, respectively, after treatment with MST-312 at various concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "K-L", ")", ...
PMC10926885	p < 0.05; p < 0.01; p < 0.001 and ***p < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11424574	Comparison of MTA2 expression between normal and tumor tissues from osteosarcoma patients using TNMplot from the TCGA database. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Comparison", "of", "MTA2", "expre...
PMC11638255	Vittorio, O. (2024).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Vittorio", ",", "O.", "(", "2024", ")", "." ] } ]
PMC8711270	Stable producer cell lines are preferred for the large-scale production of recombinant proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Stable", "producer", "cell", "lines", "are", "preferred", "for", "the", ...
PMC11225860	Fig 5 Aurkin A prevents alisertib induced cell cycle slippage and endomitosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig", "5", "Aurkin", "A", "prevents", "alisertib", "induced", "cell", "cycle", ...
PMC9318744	All tests were performed using Prism 9 (GraphPad Software, v9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "tests", "were", "performed", "using", "Prism", "9", "(", "Grap...
PMC9429973	The index date for the PK deficiency cohort was defined as the date of the first medical record with a diagnosis code related to PK deficiency while the index date for the non-PK deficiency cohort was defined as the date of a random visit during their match’s index year.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11388384	Using immunofluorescence analysis, we detected SHH on the sender cell membrane, but not in the extracellular space (Fig. 2A), consistent with prior observations that immunofluorescence often fails to detect extracellular morphogens likely because of their low abundance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11471157	If DFP were to be used in vivo, various extraction and processing steps would be required.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "If", "DFP", "were", "to", "be", "used", ...
PMC11413393	Search results were further processed using the trans-proteomic pipeline (TPP v4.7) using iProphet.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Search", "results", "were", "further", "processed", "using", ...
PMC9844987	Adjustment of the mean expression-dispersion relationship was performed by subtracting the expected log10-transformed dispersion for each promoter according to its expression level, using a running median (width 50, step size 25) of raw dispersions (log10 CV) ordered by mean expression level (TPM) across the panel, as described elsewhere (Kolodziejczyk et al., 2015; Newman et al., 2006).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767725	Excess circulating free fatty acids activate protein kinase C (PKC), impairing insulin receptor signaling and exacerbating systemic insulin resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Excess", "ci...
PMC11529598	B. Dual luciferase reporter gene assays were performed on U251 miR-3154 sponge or A172 miR-3154 sponge and their control cells transfected with wild-type or mutant TP53INP1 3’-UTR. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10809689	However, the GLS enzyme showed a significant increase in all time with the highest pick at the 24th hour (p = 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11474209	The risk of bladder cancer increases with higher levels of MC-LR as it permeates through bladder tissue, encouraging the proliferation and development of cancer in the bladder .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11753435	Our resulting Peptide Prioritization via CLIP (PepPrCLIP) pipeline integrates our generative-discriminative framework to prioritize fully novel peptide candidates with binding capacity to an input target sequence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11703896	The 2D images provide details on specific bonds and interacting residues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "2D", "images", "provide", "details", "on", "specific", "bonds", "and", "intera...
PMC9429973	Novel therapeutic strategies are warranted to overcome the natural occurrence of relapse or therapy resistance in RRMM pts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Novel", "therapeutic", "strategies", "are", ...
PMC7840816	In addition, we evaluated the expression of SOX9 in PTC cell lines; the expression levels of SOX9 mRNA and protein were also increased in TPC-1 and BCPAP cells (Fig. 1C and D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC9739791	Heptamethine cyanine dyes could also act as photocatalysts of several reactions and accumulate specifically in mitochondria .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Heptamethine", "cyanine", "dyes", "could", "also", "ac...
PMC11756514	GFP-expressing S. aureus Reynolds (CP5), Reynolds (CP8), or Reynolds (CP-) were cultivated overnight at 37°C on CSA or in THB.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9910796	Moreover, immuno-EM showed that these ER-bound zippers contain not only the precursors pp220 (Fig 4I) and pp62 (Fig 4J) but also the transmembrane protein pEP84R (Fig 4K).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240571	The sPD-L1 includes several types of soluble forms, and exosomal PD-L1 is a major feature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sPD-L1", "includes", "several", "types", "of", ...
PMC7917457	This is well below the maximum net genome size (3%–5% larger than WT adenovirus 5 genome) in which the Ad5 virion has the ability to package efficiently.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10530622	The translational relevance of these findings was explored in primary human hepatocytes isolated from male steatotic and lean donors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "translational", "relevance", ...
PMC9429973	However, in 25-30% of patients, known as B-other, no recurrent genetic aberrations relevant for the risk stratification and treatment personalization can be detected using conventional cytogenetic methods.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10940855	Uniquely, EPH–Ephrin complexes can produce bidirectional signaling, thereby affecting the EPH receptor–expressing cell (forward signaling) and the ephrin-expressing cell (reverse signaling), and ephrins can also regulate signals by EPH receptors in the same cell (17).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11335267	Consistent with the predominant expression of lipolytic relative to lipogenic genes, suggesting increased sympathetic tone , the levels of the catecholamine synthesizing enzyme tyrosine hydroxylase, as well as noradrenaline content in vWAT, were higher in Alx3-deficient mice (Fig. 2P and Q).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365983	Quantification of cilia length as fold change relative to vector controls from independent experiments (shRNA: n = 6; OE: n = 7). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10040136	The proportion of MSC in the tumour tissue was significantly correlated with the overall survival of the patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "proportion", "of", "MSC", "in",...
PMC9622879	According to and, the output energy from a PV system of home i in time slot t () in kWh can be measured as11[12pt] $$ E_(t)= GHI_i(t) S_i ^ t, $$,RES(t)=GHIi(t)·Si·ηRES·Δt,where is the total area of the solar panels of home i. is the global horizontal irradiation at the location of the solar panels of home i in time slot t. is the solar conversion efficiency of the PV system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8735881	Data are expressed as the means ±standard deviations (SD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "expressed", "as", "the", "means", "±standard", "deviations", "(", "SD"...
PMC11541409	Sphingosine kinase-1 (SPK1), a key enzyme in S1P synthesis, has been implicated in imatinib resistance in GIST cells according to KEGG analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10858941	Autophagy is a catabolic mechanism that occurs in response to nutrient starvation or oxidative stress, and ensures cell homoeostasis and survival .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Autophagy", ...
PMC11743316	Phosphorylated Akt is active on a wide range of substrates, but one of its most important targets is mTOR, which is involved in cell growth, proliferation, and survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585994	In previous studies, PAMAM has shown favorable affinity towards various small molecule nucleic acids when controlled with appropriate pH, ratio, and concentration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9429973

FFP did not differ according to the final level reached (≥3 or ≥4; both p>0.20).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FFP", "did", "not", "differ", "accordi...

PMC9429973

Methods: This study is an ongoing, prospective, open-label, multicenter, phase 2 study (ChiCTR2100043748).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "This", ...

PMC11188874

C, Effect of HDAC6 inhibitors on pan MHC-I (HLA-ABC) presentation on CD138 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", ",", "Effect", "of", "HDAC6", "inhibitors", ...

PMC11438317

These procedures were done as reported before .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "procedures", "were", "done", "as", "reported", "before", "." ] } ]

PMC11138140

Pathological hypertrophy often precedes the development of heart failure and other adverse cardiovascular events .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pathological", "hypertrophy", "often", "precedes", "the", "development", ...

PMC11655536

Cell were treated with HA at 10 μM for 48 h. D, E Lysotracker staining of RPMI-8226 (D) and U266 (E) after treated HA at 10 μM for 48 h. Right panel, mean fluorescence intensity statistics.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "...

PMC11547972

A clinical trial recently investigated the impact of 500 μM (90 mg) SFN given daily to patients with advanced pancreatic cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ...

PMC11406030

3 times/week for 3 weeks (Figure 5C) resulted in a 24% and 35% tumor reduction for LMTK3BP #1 and #2, respectively, compared to the control (p = 0.006).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

T. A. Eyre, M. L. Wang, N. N. Shah, A. J. Alencar, J. N. Gerson, M. R. Patel, B. Fakhri, E. Vandenberghe, W. Jurczak, X. N. Tan, K. L. Lewis, T. Fenske, Y. Wang, C. C. Coombs, I. Flinn, D. Lewis, S. Le Gouill, M. Gandhi, C. Chay, M. L. Palomba, J. A. Woyach, J. M. Pagel, N. Lamanna, J. P. Sharman, D. J. Andorsky, J. B. Cohen, M. A. Barve, P. Ghia, M. Yin, P. L. Zinzani, C. Ujjani, Y. Koh, K. Izutsu, E. Lech-Maranda, J. Kherani, C. Tam, S. Sundaram, B. Nair, D. E. Tsai, M. Balbas, A. R. Mato, C. Y. Cheah Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Center, Oxford, United Kingdom; MD Anderson Cancer Center, Houston; Medical College of Wisconsin, Milwaukee; Sylvester Comprehensive Cancer Center, Miami; University of Pennsylvania, Philadelphia; Florida Cancer Specialists/Sarah Cannon Research Institute, Sarasota; University of California San Francisco, San Francisco, United States of America; Hope Directorate St. James Hospital, Dublin, Ireland; Maria Sklodowska-Curie National Research Institute of Oncology, Krakow, Poland; Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Australia; Division of Hematology, Mayo Clinic, Rochester; University of North Carolina at Chapel Hill, Chapel Hill; Sarah Cannon Research Institute, Nashville, United States of America; University Hospitals Plymouth NHS, Plymouth, United Kingdom; Service d’hématologie clinique du CHU de Nantes, INSERM CRCINA Nantes-Angers, NeXT Université de Nantes, Nantes, France; Virginia Cancer Specialists, Fairfax; Messino Cancer Centers, Asheville; Memorial Sloan Kettering Cancer Center, New York; The Ohio State University Comprehensive Cancer Center, Columbus; Loxo Oncology at Lilly, Stamford; Herbert Irving Comprehensive Cancer Center, Columbia University, New York; Willamette Valley Cancer Institute and Research Center, US Oncology Research; Rocky Mountain Cancer Centers, US Oncology Research, Eugene; Winship Cancer Institute, Emory University, Atlanta; Mary Crowley Cancer Research, Dallas, United States of America; Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy; Medicine III, LMU University Hospital, Munich, Germany; Institute of Hematology “Seràgnoli” University of Bologna, Bologna, Italy; Fred Hutchinson Cancer Research Center, Seattle, United States of America; Internal Medicine, Seoul National University Hospital, Seoul, South Korea; National Cancer Center Hospital, Tokyo, Japan; Institute of Hematology and Transfusion Medicine, Warsaw, Poland; Peter MacCallum Cancer Center, Royal Melbourne Hospital, and University of Melbourne, Melbourne, Australia; Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States of America Background: Covalent BTK inhibitors (BTKi) have transformed the management of mantle cell lymphoma (MCL), but these treatments are not curative and the majority of patients (pts) will require additional treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11271278

Based on H3K27ac HiChIP and ChIP-seq signal, we observed four enhancers e1-e4, upstream of FOXA1 on chromosome 14, hijacked to the ETV1 promoter in LNCaP and MDAPCA2B cells (Fig. 3A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11531744

Heatmap of the 243 IRGs expression profiles. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Heatmap", "of", "the", "243", "IRGs", "expression", "profiles", ".", "(" ] } ]

PMC10729469

To confirm migration and accumulation of Tregs to the brain, TCRAβ-Tregs or polyclonal Tregs were radiolabeled with F-fluorodeoxyglucose (F-FDG, Cardinal Health, Omaha, NE).

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PMC11422150

So we focused on the serum NO concentration to confirm that.

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PMC11790971

d–f Balanced accuracies and impurity scores of all experiments are shown in the bar plots.

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PMC11774251

Topical Tan-I alleviated key features of psoriatic symptoms in vivo, including epidermal hyperplasia and skin inflammation.

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PMC11449273

Our findings again suggest a role for plakoglobin in the modulation of S100A4 expression in both p53-WT and mutant (p53-175 and -273)- expressing cells.

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PMC10761218

The leaf methanolic extract was the most effective, followed by the stem methanolic extract in the HepG2 cell line.

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PMC11257988

Finally, RAS also activates the RALGDS protein, which is a guanine nucleotide exchange factor for MAPK and RAL and phospholipase C activation, leading to the transcription of multiple transcription factors, including ELK1 and activation protein 1 (AP1).

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PMC11527437

For example, less than 5% of USA White and Black patients with pancreatic ductal adenocarcinoma (PDAC) would be eligible for TCR-T using the HLA-C*08:02–restricted KRAS G12D targeting TCRs of Leidner and colleagues (9).

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PMC9985266

The procedure was as follows: predenaturation at 95 °C for 10 min, denaturation at 95 °C for 45 s, and methylation at 95 °C for 35 cycles.

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PMC8414691

In the last two decades, it has been shown that mutations in genes encoding a variety of chromatin factors and epigenetic regulators, such as DNA or histone modifying enzymes and members of ATP-dependent chromatin remodeling complexes, are crucial players in human genetic diseases and cancer [1–4].

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PMC9878562

Moreover, the inhibitor abolished VAL-wt-mediated migration of VAL-ko in response to CXCL12 ( Figure 6A ).

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PMC9429973

Treatment was ongoing for 9 (50%) patients (Cohort 1, n=1; Cohort 2, n=8).

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PMC10988555

Therefore, analyzing the results obtained in Table 1 and Figure 7 it is possible to say that complexes 2–4 have higher activity and % of internalization at 37 °C due to the contribution of active and passive mechanisms.

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PMC8170755

The extracted RNA was further purified using DNase I (Thermo Fisher Scientific Inc.) digestion.

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PMC11297139

Enriched motifs of the dysregulated cREs were identified by using HOMER findMotifsGenome knownResults with the parameters “-size given”.

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PMC11519583

In fact, the binding of Wnt5b and Wnt11 to Ror2 was increased in the presence of increasing amounts of Wnt11 or Wnt5b (Fig. 6c), indicating that cooperative binding of Wnt5b and Wnt11 to Ror2 might be attributable to their synergistic action.

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PMC11359735

Anopheles stephensi (Liston strain) mosquitoes were reared in the insectary at the Johns Hopkins Malaria Research Institute and infected with P. berghei ANKA strain as described previously (9).

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PMC11794568

Survival curve analysis further indicated that patients with low CRIP1 expression had poorer OS compared to those with high expression (Fig. 2D).

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PMC11723210

Two representative subregions (yellow and blue boxes) contain one individual cell, magnified in Figure 3(a3,b3).

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PMC11451940

Our initial idea was to generate square-planar mixed-ligand ionic systems of the type [M(Lap)(N–N)]NO3, where M = Cu(ii) and Zn(ii), and N–N stands for a bidentate N-donor aromatic imine, with the aim to prepare systems with good solubility in water and possibility to influence the cell cycle of cancer cells.

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PMC11075223

Except the above cultivars, Actaea purpurea , Actaea japonica, Cimicifuga simplex black cohosh and Actaea asiatica Hara are often used as counterfeits or fake products regionally due to its similarity in the plant appearance and efficacy.

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PMC11789597

Representative confocal microscope images showing the levels of TMRE (red) in MM1S cells expressing shNC or shCAV1.

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PMC11499381

For AF-647 and AF-568 analysis, the combined, log-transformed fluorescence intensity values were analyzed by repeated-measures one-way ANOVA with post-hoc Dunnett's test, comparing each condition to the WT receptor condition.

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PMC7504302

Similarly, deregulated amplification of MYC gene (MYC proto-oncogene, bHLH transcription factor, chr location: 8q24), a genetic event that can be recapitulated in asbestos-induced MPMs of wild type murine models, has been reported in a small fraction of MPM cases (<5%) .

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PMC11012313

After incubation, cells were washed using PBS by centrifuging at 1500 rpm for 5 min, followed by incubation with Zombie Violet™ Viability dye (Biolegend, San Diego, CA, USA).

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PMC11721587

The resultant beads were further used as substrates for second round of kinase assay with CK1.

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PMC9429973

The results were statistically analyzed.

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PMC6835428

This is an important rate-limiting enzyme in both normal and tumor DNA biosynthesis.

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PMC11585994

Scale bar, 20 μm.

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PMC9429973

The investigator-assessed overall response rate (ORR) was 75%, with median response duration of 21.4 months.

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PMC9429973

To assess different sources of variance ANOVA of a 3x3x3 experiment evaluating marker expressions on different cell populations in the blood of healthy donors using Quantibrite-PE beads was performed addressing technical variation (day, instrument) and biological variation.

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PMC10969097

In terms of in vivo and in vitro studies, the focus was on selecting those that investigated the use of mushroom extracts combined with anticancer therapies.

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PMC7433824

Then the spots were reduced and alkylated with 10 mM DTT and 55 mM iodoacetamide, respectively.

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PMC6889484

To create vectors pA33G(DK) and pA3x3G(DK), the following fragments were joined by ligation in the same reading frame: the 5′ direct repeat of A3G-D128K (1 to 1,083 nt of A3G for the A33G(DK) vector and the same 1 to 1,083 nt plus three in-frame stop codons, TGA-TAA-TGA for the A3x3G(DK) vector); 3′ direct repeat of A3G-D128K (nt 184 to 1,152); and P2A fused to eYFP (lacking a start codon).

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PMC11791478

The internalization of XB002 and its parental antibody 25A3 was assessed in the TF-expressing A431 tumor cell line.

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PMC11721295

We next set up a cell culture system (Figure 5D), wherein cell lysates and conditioned media (CM) were collected from the different treatment groups, MRTX or Soto, to assess transcriptional activation and secretion of cytokines and growth factors modulated in our scRNA-seq data set upon KRAS activation (see Figure 2).

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PMC8336407

Finally, our results showed that the groups treated with extract only but not t-BHP, had lower cell viability [E 1.5 mg/mL (p value = 0.016), E 2.0 mg/mL (p value ≤ 0.001), and E 2.5 mg/mL (P value ≤ 0.001)] when compared to the control group.

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PMC5261804

We are currently developing a PPI Portal website where PPI essentiality data, as well as data from our OncoPPi screening study , can be mined and viewed (A. Ivanov, B. Revennaugh, et al, manuscript in preparation).

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PMC11767817

Notably, we demonstrated that the hypoxic conditions changed the pattern of affected proteins, including DKK-4, SIRT2, and p27, being downregulated compared to normoxic conditions.

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PMC11787355

i Percentages of different CD8 T cell subsets of transferred T cells in host blood.

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PMC11805741

Peak numberTR (min)λ max (NM)[M + H] (m/z)Carotenoid IdentificatonFormulaCompound (%)15475851Antheraxanthin monoesterM-C18:011.725.8NDND--4.739.7470861.6Astaxanthin monoesterM-C18:123416.9NDND--12.2526458719.77Zeaxanthin monoesterM-C9:148.3ND: Not Detected.

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PMC11588085

In both SKOV3-KRAB and OVCAR3-KRAB cell lines, SP was significantly enriched after XIST KDs: OVCAR3-KRAB cells showed a threefold increase in SP for both sgXIST7 and sgXIST9 (Fig. 2F); SKOV3-KRAB cells showed an 81-fold increase in SP for sgXIST7 and an 18-fold increase in SP for sgXIST9 (Fig. 2G).

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PMC6487404

Inhibition of the CYP3A4- catalyzed metabolism as well as the OATP1B1-mediated hepatic uptake of REG by cyclosporine was considered as the probable cause of the observed interaction.

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PMC11026382

Gray pixels mark mutations with statistically insignificant epistasis.

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PMC9429973

At a median follow-up of 42 months (range, 2-106 months), the estimated 3 years PFS and OS for the entire population were 80% and 89%, respectively.

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PMC10040136

The proportion of MSC obtained using the FACS method in the other 50 samples was significantly correlated with progression-free survival (C).

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PMC9895440

n = 12 donors of n = 6 experiments except for Teff n = 6 of n = 3 experiments.

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PMC8481254

In addition, WB assay results showed that O-GlcNAcylation and the expression of YAP and OGT were markedly inhibited in a dose-dependent manner by CA (Fig. 2H).

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PMC11711127

Recognition of the relevant Ag through the pMHC-TCR interaction in F-actin-dependent protrusions or microclusters initiates T cell activation (78).

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PMC11754436

Further in vivo model studies are required to validate the findings presented here.

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PMC9429973

S. Aggarwal, S. Kumar, H. Topaloglu, A. Bela, O. Topaloglu Health Economics and Outcomes Research, NOVEL Health Strategies, Chevy Chase; Health Economics and Outcomes Research, NOVEL Health Strategies, Columbia; Systematic Literature Review Group, NOVEL Health Strategies, Chevy Chase, United States of America Background: Sickle cell disease (SCD) is a group of inherited red blood cell disorders.

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PMC9318744

Low-passage SARS-CoV-2 stocks were used in this study.

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PMC9596868

K-L) Percentage cell viability of A2780cisR and HCT116 cells, respectively, after treatment with MST-312 at various concentrations.

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PMC10926885

p < 0.05; **p < 0.01; ***p < 0.001 and ****p < 0.0001.

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PMC11424574

Comparison of MTA2 expression between normal and tumor tissues from osteosarcoma patients using TNMplot from the TCGA database. (

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PMC11638255

Vittorio, O. (2024).

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PMC8711270

Stable producer cell lines are preferred for the large-scale production of recombinant proteins.

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PMC11225860

Fig 5 Aurkin A prevents alisertib induced cell cycle slippage and endomitosis.

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PMC9318744

All tests were performed using Prism 9 (GraphPad Software, v9).

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PMC9429973

The index date for the PK deficiency cohort was defined as the date of the first medical record with a diagnosis code related to PK deficiency while the index date for the non-PK deficiency cohort was defined as the date of a random visit during their match’s index year.

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PMC11388384

Using immunofluorescence analysis, we detected SHH on the sender cell membrane, but not in the extracellular space (Fig. 2A), consistent with prior observations that immunofluorescence often fails to detect extracellular morphogens likely because of their low abundance.

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PMC11471157

If DFP were to be used in vivo, various extraction and processing steps would be required.

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PMC11413393

Search results were further processed using the trans-proteomic pipeline (TPP v4.7) using iProphet.

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PMC9844987

Adjustment of the mean expression-dispersion relationship was performed by subtracting the expected log10-transformed dispersion for each promoter according to its expression level, using a running median (width 50, step size 25) of raw dispersions (log10 CV) ordered by mean expression level (TPM) across the panel, as described elsewhere (Kolodziejczyk et al., 2015; Newman et al., 2006).

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PMC11767725

Excess circulating free fatty acids activate protein kinase C (PKC), impairing insulin receptor signaling and exacerbating systemic insulin resistance.

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PMC11529598

B. Dual luciferase reporter gene assays were performed on U251 miR-3154 sponge or A172 miR-3154 sponge and their control cells transfected with wild-type or mutant TP53INP1 3’-UTR. *

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PMC10809689

However, the GLS enzyme showed a significant increase in all time with the highest pick at the 24th hour (p = 0.001).

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PMC11474209

The risk of bladder cancer increases with higher levels of MC-LR as it permeates through bladder tissue, encouraging the proliferation and development of cancer in the bladder .

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PMC11753435

Our resulting Peptide Prioritization via CLIP (PepPrCLIP) pipeline integrates our generative-discriminative framework to prioritize fully novel peptide candidates with binding capacity to an input target sequence.

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PMC11703896

The 2D images provide details on specific bonds and interacting residues.

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PMC9429973

Novel therapeutic strategies are warranted to overcome the natural occurrence of relapse or therapy resistance in RRMM pts.

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PMC7840816

In addition, we evaluated the expression of SOX9 in PTC cell lines; the expression levels of SOX9 mRNA and protein were also increased in TPC-1 and BCPAP cells (Fig. 1C and D).

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PMC9739791

Heptamethine cyanine dyes could also act as photocatalysts of several reactions and accumulate specifically in mitochondria .

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PMC11756514

GFP-expressing S. aureus Reynolds (CP5), Reynolds (CP8), or Reynolds (CP-) were cultivated overnight at 37°C on CSA or in THB.

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PMC9910796

Moreover, immuno-EM showed that these ER-bound zippers contain not only the precursors pp220 (Fig 4I) and pp62 (Fig 4J) but also the transmembrane protein pEP84R (Fig 4K).

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PMC11240571

The sPD-L1 includes several types of soluble forms, and exosomal PD-L1 is a major feature.

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PMC7917457

This is well below the maximum net genome size (3%–5% larger than WT adenovirus 5 genome) in which the Ad5 virion has the ability to package efficiently.

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PMC10530622

The translational relevance of these findings was explored in primary human hepatocytes isolated from male steatotic and lean donors.

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PMC9429973

However, in 25-30% of patients, known as B-other, no recurrent genetic aberrations relevant for the risk stratification and treatment personalization can be detected using conventional cytogenetic methods.

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PMC10940855

Uniquely, EPH–Ephrin complexes can produce bidirectional signaling, thereby affecting the EPH receptor–expressing cell (forward signaling) and the ephrin-expressing cell (reverse signaling), and ephrins can also regulate signals by EPH receptors in the same cell (17).

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PMC11335267

Consistent with the predominant expression of lipolytic relative to lipogenic genes, suggesting increased sympathetic tone , the levels of the catecholamine synthesizing enzyme tyrosine hydroxylase, as well as noradrenaline content in vWAT, were higher in Alx3-deficient mice (Fig. 2P and Q).

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PMC11365983

Quantification of cilia length as fold change relative to vector controls from independent experiments (shRNA: n = 6; OE: n = 7). (

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PMC10040136

The proportion of MSC in the tumour tissue was significantly correlated with the overall survival of the patients.

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PMC9622879

According to and, the output energy from a PV system of home i in time slot t () in kWh can be measured as11[12pt] $$ E_(t)= GHI_i(t) S_i ^ t, $$,RES(t)=GHIi(t)·Si·ηRES·Δt,where is the total area of the solar panels of home i. is the global horizontal irradiation at the location of the solar panels of home i in time slot t. is the solar conversion efficiency of the PV system.

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PMC8735881

Data are expressed as the means ±standard deviations (SD).

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PMC11541409

Sphingosine kinase-1 (SPK1), a key enzyme in S1P synthesis, has been implicated in imatinib resistance in GIST cells according to KEGG analysis.

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PMC10858941

Autophagy is a catabolic mechanism that occurs in response to nutrient starvation or oxidative stress, and ensures cell homoeostasis and survival .

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PMC11743316

Phosphorylated Akt is active on a wide range of substrates, but one of its most important targets is mTOR, which is involved in cell growth, proliferation, and survival.

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PMC11585994

In previous studies, PAMAM has shown favorable affinity towards various small molecule nucleic acids when controlled with appropriate pH, ratio, and concentration.

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