OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9429973	Methods: Blood samples were obtained from 62 CLL and 60 MM patients from eight hematology departments in Poland and were assessed at pre and post-vaccination in three time points.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11487720	Mouse Wwox cDNA expression constructs were made: 1) WWOX-pECFPC1 , 2) EGFP-TRAF2(124–233) , and 3) ECFP-TRAF2 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mouse", "Wwox", "...
PMC9027909	For example, Puthia et al., (2006) observed that B. ratti induced apoptosis and increased the permeability of the gut epithelium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Adverse events (AE) were rated according to the NCI Common Terminology Criteria for Adverse Events (CTCAE) 5.0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Adverse", "events", ...
PMC11763126	786-O cells ( cells in 0.2 ml PBS) were subcutaneously injected into the axilla.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "786-O", "cells", "(", "cells", "in", "0.2", "ml", ...
PMC11790971	In addition to single-cell-line wells (i.e., monoclonal wells), artificial cell line pools (i.e., artificial pools) were created by combining multiple cell lines to simulate the cell line selection process.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11657695	Similarly, KCNA2 expression decreases after 8 h of treatment, until reaching 75% silencing after 24 h (Fig. 3B, middle panel).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9065483	Bands were quantified by densitometry relative to the actin-loading control and expressed as a phosphorylated: total STAT1/2 ratio (n = 3, mean ± SD; ns = no significance, ∗∗p < 0.01 by one-way ANOVA). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10571053	Gateway Multisite LR recombination was used to construct the final mammalian expression constructs from the Entry clones using the manufacturer’s protocols (Thermo Fisher Scientific, Waltham, MA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8469018	They noticed that teriflunomide induced apoptosis in cells and addition of uridine to cell culture medium reversed (only partially) observed apoptotic changes but merely at 200 µM of teriflunomide (48 h-treatment).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4277423	Using deep sequencing Cho et al. recently showed high frequencies of CCR5 indels in K562 cells co-transfected with DNA plasmids encoding Cas9 and 2 of 28 CCR5 sgRNAs, but no mutations at measurable frequency (about 0.01%) at these putative off-target sites to these 2 CCR5 sgRNAs .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10745221	The cells were divided into 500 μL aliquots, which were lysed at 13,000 g at 4°C for 5 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells...
PMC11700523	Two-way ANOVA was utilized for statistical comparisons among more than three groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two-way", "ANOVA", "was", "utilized", "for", "statistical", "comparisons", "among", ...
PMC11790599	The primer sequences can be obtained upon request.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primer", "sequences", "can", "be", "obtained", "upon", "request", "." ] } ]
PMC11765678	Adriamycin (ADR, >98%) was the gift of the Drug Synthesis and Chemistry Branch, Developmental Therapeutic Program of NCI, NIH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11590870	Three of the fourteen peptides previously identified have this amino acid within their structure .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "of", "the", "fourteen", "peptides", "previously", "identified...
PMC10926885	In addition, several immunological pathways and activities were linked to NDE1 by KEGG and GO enrichment studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "several", "immu...
PMC11678841	Given that it is well known that p38 activation is strongly regulated by MAPK kinases MKK3/6 and MAPK-ERK1/2 , Western blotting experiments were performed to evaluate GA ability to modulate these pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11753435	It relies on the enzymatic activity of biotin protein ligase to biotinylate proteins in proximity to a bait of interest.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "relies", "on", "...
PMC8956657	R24A and R33A mutants had the greatest effect on binding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "R24A", "and", "R33A", "mutants", "had", "the", "greatest", "effect", "on", "binding", "." ...
PMC10890055	The billets were tempered for 10 min in the extrusion die.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "billets", "were", "tempered", "for", "10", "min", "in", "the", "extrusion", ...
PMC11701801	The CASP6 gene in SMARCA4/SMARCA2-deficient cells and SS18–SSX fusion cells was upregulated by simultaneous knockdown of CREBBP and EP300 (Fig. 4E); thus, these results indicate that simultaneous inhibition of CBP/p300 in SMARCA4/SMARCA2-deficient cells and SS18–SSX fusion cells induces apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3765139	In particular CD133 (Prominin 1), which is expressed on stem and early progenitor cells (CD34+ hematopoietic stem cells) and tumor-initiating cells of several malignancies , is prominent subject of ongoing research.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10490530	As per the supplier’s recommendation, various human cell lines, i.e., HT1080, A2780, and SKOV3, were cultured in DMEM, and the A549 and MCF7 were cultured in RPMI1640 media, supplemented with 10% fetal bovine serum and 1% penicillin-streptomycin solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O"...
PMC9813422	This mini review summarizes our current knowledge of the tethering sites of viral episomes, such as EBV, KSHV, and HBV, on host chromosomes analyzed by three-dimensional genomic tools.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6684588	We recently demonstrated the feasibility of using a FST288-based fusion protein to promote dose-dependent, localized growth of skeletal muscle in normal mice without detectable systemic effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11532793	Together, these changes result in significant improvements to an already very competitive DTE pipeline.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Together", ",", "these", "changes", "result", "in", "signif...
PMC9429973	Safety-set includes patients receiving ≥1 dose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Safety-set", "includes", "patients", "receiving", "≥1", "dose", "." ] } ]
PMC11519567	The diameter of the bleached area is ~1 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "diameter", "of", "the", "bleached", "area", "is", "~1", "μm", "." ] } ]
PMC11594806	Further studies and clinical trials are crucial to validate these findings and optimize therapeutic strategies, particularly for osteosarcoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "studies", "and", "clin...
PMC9429973	Conversely, the rising number of patients with Sickle Cell Disease (SCD) in many European countries has resulted in increased demand for blood transfusion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11365427	P value below 0.05 was considered statistically significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "value", "below", "0.05", "was", "considered", "statistically", "significant", "." ] } ]
PMC9878562	In neoplasms, the chemokine system plays a promiscuous role depending on the type of cancer, the cellular and environmental context, and the involved chemokine axis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11371627	CSF flow cytometry revealed a slight elevation of HLA-DR CD4 (27.8%, reference <24%) and HLA-DR CD8 cells (75.5%, reference <63,4%), a CD4/CD8 ratio of 1.4 and an elevation of natural killer cells (NKs) (5,8%) (Figure 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	ORR/CR were assessed per local investigator according to the Lugano criteria using CT and/or PET-CT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ORR/CR", "were", "assessed", "per", "local", "investigator", ...
PMC7762347	It is known that the formation of micronuclei correlates with DNA double-strand break formation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "known", "that", "the", "formation", "of", "micronucl...
PMC10882807	However, the underlying mechanisms of HCCprogression or metastasis have not been fully elucidated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "underlying", "mechanisms", "of", "HCCprogressio...
PMC10968586	Among all HT doses tested (1–40 μM), only 20 μM affected viability of THP-1 cells after 72 h .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "all",...
PMC11672881	A synergistic cytotoxic effect was observed when piperlongumine was combined with a pancratistatin analog, which activates the intrinsic apoptotic pathway through mitochondrial targeting .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9739791	Flavins are a group of biomolecules that play a key role in aerobic metabolism, embryonic development, and programmable cell death .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Flavins", "a...
PMC11763111	We conducted a comprehensive analysis of 4KO-LLT1 CAR-T cells, evaluating cytokine secretion, antigen-specific proliferation, immunophenotyping, and transcriptomic profiling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "conduc...
PMC9429973	Mixed donor-recipient chimerism was found in the buccal epithelium of 49 patients with the proportion of own recipient DNA ranging from 11% to 98%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8658661	One of the biomarkers of tumor processes in the liver is a change in the level of alpha-fetoprotein (AFP)—plasma protein produced by the yolk sac and the fetal liver during fetal development .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730320	A Read alignments for the proband and unaffected parents were visualized using the Integrative Genomics Viewer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Read", "alignments", "for", "the", "proband", ...
PMC11782508	Additionally, the presence of sulfur (mass ratio 11.15) likely originates from cysteine (Cys) and methionine (Met) residues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11752740	The increased expression of Caspase3 further suggests a heightened apoptotic response .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "increased", "expression", "of", "Caspase3", "further", "suggests", "a", "heightened"...
PMC11764090	Boosting antioxidant enzymes to clear excess ROS is a key strategy for plants to handle cold stress.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Boosting", "antioxidant", "enzymes", "to", "clear...
PMC9429973	Results: Results showed that the percentage of CD16 monocytes in PB and BM was significantly increased in AA patients compared with that in HDs, and the proportion of CM was decreased.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8633974	First, computational assessments suggest that proviral targeting choices require affirmation in patient-derived HIV-1 isolates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "First", ",", "computational", "assessments", "suggest", "that", ...
PMC11144200	Meanwhile, to reduce the DOX-induced cardiotoxicity and toxicity within various organs like the liver or kidney, liposomal delivery systems were developed to passively target DOX to tumor .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: To evaluate the efficacy, safety, and tolerability of magrolimab + azacitidine + venetoclax in previously untreated patients with AML who are ineligible for intensive chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Patients (pts) with IBD are at an increased risk of cancer secondary to long-standing intestinal inflammation and secondary to immunosuppressive therapies, including but not limited to colorectal cancer, hepatobiliary tract cancer, Hodgkin, and non-Hodgkin lymphomas.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7602170	Activated mTORC2 directly activates AKT via phosphorylation at Ser473 and SGK1 (S422), controlling ion migration and cell growth .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activated", "mTORC2", ...
PMC11756514	Bacteria with an OD600 of 0.4 in TBS+ or TBS, 10 mM EDTA, and 0.5% BSA were incubated with decreasing biotin-langerin ECD or biotin-MBL concentrations for 30 min at 37°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	Our TCR-T cell manufacturing process transduced both CD4 and CD8 T cells, and we observed that CD4 TCR-T cells, even without the co-receptor CD8, were activated in an antigen-dependent manner (Supplementary Fig. 6a–c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11291697	The figure was created with BioRender (https://www.biorender.com/).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "figure", "was", "created", "with", "BioRender", "(", "https://www.biorender.com/", ")", "." ] ...
PMC11541241	They failed to obtain a null mutant in tor1, indicating that TOR was vital in U. maydis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "failed", "to", "obtain", "a", ...
PMC9429973	The next important step of this project is to test PK properties in-vivo and validate the promising findings observed in-vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "next", "important", ...
PMC11640555	All stained sections were observed and analyzed in a blinded manner at an objective lens of 20x and 40x by using a Nikon Eclipse Ci-L microscope.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11535726	Prior to the incorporation of molecular data, the taxonomy of Kirschsteiniothelia was challenging, resulting in controversial classifications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prior", "to", "the", "incorporati...
PMC11478724	The cells were allowed to incubate for 2 min, following which the supernatant was removed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "allowed", "to", "incubate", ...
PMC11514418	This substance is commonly used for the conditioning of malignant tumors in TCM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "substance", "is", "commonly", "used", "for", "the", "conditioning",...
PMC11791264	SETD7 methylates LC3B at K51 and promotes LC3B ubiquitination and degradation, resulting in reduced formation of autophagosomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SETD7", "methylates", "LC3B", "at", "K...
PMC11721064	β-actin or glyceraldehyde-3-phosphate dehydrogenase (GAPDH) served as loading controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β-actin", "or", "glyceraldehyde-3-phosphate", "dehydrogenase", "(", "GAPDH", ")", "served", ...
PMC9429973	Pharmacodynamic reporting will focus on HbF changes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pharmacodynamic", "reporting", "will", "focus", "on", "HbF", "changes", "." ] } ]
PMC11371627	Dominant features at presentation were raised CK, muscular weakness and atrophy, decreasing physical performance and exercise intolerance which the patient had only noted after COVID-19 disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7215722	Here we could show that Caco-2 cells exposed to DSS treatment exhibit an upregulation in the transcriptional levels of IL-1α, IL-6, and TNFα cytokines, accompanied by a downregulation in the transcription level of the anti-inflammatory cytokine IL-10.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10033453	Tumor volume was measured three times weekly until humane endpoint or end of study (day 14). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumor", "volume", "was", "measure...
PMC11699465	TMEM199 also mediates the early stage of influenza A virus infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TMEM199", "also", "mediates", "the", "early", "stage", "of", "influenza", "A", "virus...
PMC9429973	Normal Hb levels achieved within 61 days after a transfusion were excluded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Normal", "Hb", "levels", "achieved", "within", "61", "days", "after", "a", ...
PMC4695073	The threshold cycle (Ct) values were detected and normalized against that of β-actin internal control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "threshold", "cycle", "(", "Ct", ")",...
PMC6163708	More than half of tumor cells were sensitive to GANT61 to various extents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "than", "half", "of", "tumor", "cells", "were", "sensitive", "...
PMC9812014	VSV is a zoonotic arbovirus that is related to rabies viruses and belongs to the Rhabdoviridae family.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "VSV", "is", "a", "zoonotic", "arbovirus", "...
PMC11670954	However, following LPS treatment, trans-epithelial electrical resistance (TEER) decreases, while FITC-dextran permeability increases, and the expression levels of Occludin, ZO-1, and Claudin5 decrease .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10975211	The bioconjugation of buforins with various entities, such as nanoparticles, antibodies, or targeting ligands, aims to improve their pharmacokinetics, biodistribution, cell-specific delivery, and targeting of cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10452486	Garrido , in a book titled “MHC class-I loss and cancer immune escape”, categorized the loss of HLA-Ia in human cancer into several groups, as follows: Type 1:Tumor cells can lose all of the six HLA-I alleles present in the normal cells;Type 2:Tumor cells can lose a single HLA haplotype or one set of HLA-Ia genes localized on chromosome 6 (HLA-A, B, and C);Type 3:Tumor cells can downregulate an HLA-A, B or C locus, producing a phenotype with only four HLA-Ia alleles,Type 4:Tumor cells can lose a single HLA-I allele out of the six expressed by somatic cells;Type 5:Tumor cells can lose HLA-Ia (classical) alleles and upregulate the expression of HLA-Ib (non-classical) haplotypes, namely HLA-E, HLA-F, and HLA-G), primarily based on the correlation between the loss of HLA-Ia, concomitant with the upregulation of HLA-Ib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We report here long-term outcomes with a median follow-up of 56.8 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "report", "here", "long-term", "outcomes", "with", "a", "median", "follow-u...
PMC6889484	Cells were washed to remove PHA-P, and CD4 T cells were isolated using the Dynal CD4 Positive Isolation Kit (Invitrogen).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells",...
PMC11753435	Plates were read on a microplate reader (Tecan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plates", "were", "read", "on", "a", "microplate", "reader", "(", "Tecan", ")", "." ] ...
PMC11476222	The RT range (min) was set to ±0.5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "RT", "range", "(", "min", ")", "was", "set", "to", "±0.5", "." ] } ]
PMC9429973	One patient with BCS died.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "patient", "with", "BCS", "died", "." ] } ]
PMC10873328	The mRNA expression level of TGFBI, AKAP12, GPC1 and TGM2 after transfected with HIF1a-plasmid. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mRNA", "expression", "level", "of", ...
PMC9985266	In conclusion, our results show that IL-27 can inhibit DNMT1-mediated methylation of the MEG3 promoter, thereby upregulating MEG3 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ...
PMC11703896	For the first time, the current study reported that rapamycin has a binding affinity with ALK, EGFR, FGFR, MET, and ROS1 receptors expressed in the lung cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9031474	Interestingly, structurally related eudasmane sesquiterpenoids and meroterpenoids lead to the attenuation of NF-κB dependent pathways .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "structurally", "related", "eudasmane",...
PMC11476004	When these errors are not prepared or improperly repaired, they negatively affect the stability of the genome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "these", "errors", "are", "not"...
PMC11650848	Cognitive outcomes were assessed using the Wechsler Intelligence Scale for Children 4th UK Edition (WISC-IV), with neural activity during language tasks quantified using magnetoencephalography (MEG).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11743414	The effects of silencing and overexpression were evaluated by qRT-PCR and Western blot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effects", "of", "silencing", "and", "overexpression", "were", "evalu...
PMC11739484	Transfected A375 cells were seeded in 96-well plates at a density of 3000 cells per well.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transfected", "A375", "cells", "were", "seeded", ...
PMC10944868	However, despite tubulin inhibitors have demonstrated significant efficacy in the treatment of cancer, it is important to note that tubulin inhibitors are not specific to cancer cells and can affect healthy cells that divide rapidly, such as bone marrow and gastrointestinal cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	TAFA is a humanized CD19-directed cytolytic monoclonal antibody that contains an IgG1/2 hybrid Fc domain with 2 amino acid substitutions to modify the Fc-mediated functions of the antibody and mediates B-cell lysis through apoptosis and immune effector mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11694066	Because several PARPi plus ATRi combinations are currently being investigated in early-phase clinical trials (e.g., NCT04972110 and NCT03462342), we evaluated this combination in DSRCT cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306331	Constructs were cloned with InFusion (Clontech) using backbone PCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Constructs", "were", "cloned", "with", "InFusion", "(", "Clontech", ")", "using", "ba...
PMC11371747	Indeed, clinical studies also showed a relation of 5FU-LV efficacy with FPGS expression (Chazal et al., 1997; Cheradame et al., 1997).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The primary endpoints were response to therapy (hematological, PET, VEGF and clinical, which will be referred to as responseH, P, V, C, respectively), and time to next therapy (TTNT), defined as time from institution of regimen of interest to next therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The most common non-hematological toxicity events were nausea, fatigue and anorexia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most", "common", "non-hematological", "toxicity", "events", "were", "nausea", ...
PMC11747467	J, K) In ERBB2-silenced luminal cells and ERBB2-overexpressing basal cells, Western blot analysis was performed to measure the expression changes of ERBB2, STAT3, and pSTAT3 (Tyr705). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612315	Mechanical allodynia was assessed via von Frey filaments (NC12775-99; North Coast Medical, CA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mechanical", "allodynia", "was", ...
PMC11585565	The analysis of the wild-type and mutant CNNM4 proteins was the same as the analysis of mRNA decay, however, the wild-type and mutant CNNM4 protein levels were normalized to the GAPDH protein level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7452526	Amino acid can also reduce and bind silver ions through amino and carbonyl groups .Figure 1UV–Visible absorption spectrum of the synthesized silver nanoparticles at different times (10, 30, and 120 min).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Methods: Blood samples were obtained from 62 CLL and 60 MM patients from eight hematology departments in Poland and were assessed at pre and post-vaccination in three time points.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11487720

Mouse Wwox cDNA expression constructs were made: 1) WWOX-pECFPC1 , 2) EGFP-TRAF2(124–233) , and 3) ECFP-TRAF2 .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mouse", "Wwox", "...

PMC9027909

For example, Puthia et al., (2006) observed that B. ratti induced apoptosis and increased the permeability of the gut epithelium.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9429973

Adverse events (AE) were rated according to the NCI Common Terminology Criteria for Adverse Events (CTCAE) 5.0.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Adverse", "events", ...

PMC11763126

786-O cells ( cells in 0.2 ml PBS) were subcutaneously injected into the axilla.

[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "786-O", "cells", "(", "cells", "in", "0.2", "ml", ...

PMC11790971

In addition to single-cell-line wells (i.e., monoclonal wells), artificial cell line pools (i.e., artificial pools) were created by combining multiple cell lines to simulate the cell line selection process.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11657695

Similarly, KCNA2 expression decreases after 8 h of treatment, until reaching 75% silencing after 24 h (Fig. 3B, middle panel).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9065483

Bands were quantified by densitometry relative to the actin-loading control and expressed as a phosphorylated: total STAT1/2 ratio (n = 3, mean ± SD; ns = no significance, ∗∗p < 0.01 by one-way ANOVA). (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10571053

Gateway Multisite LR recombination was used to construct the final mammalian expression constructs from the Entry clones using the manufacturer’s protocols (Thermo Fisher Scientific, Waltham, MA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8469018

They noticed that teriflunomide induced apoptosis in cells and addition of uridine to cell culture medium reversed (only partially) observed apoptotic changes but merely at 200 µM of teriflunomide (48 h-treatment).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC4277423

Using deep sequencing Cho et al. recently showed high frequencies of CCR5 indels in K562 cells co-transfected with DNA plasmids encoding Cas9 and 2 of 28 CCR5 sgRNAs, but no mutations at measurable frequency (about 0.01%) at these putative off-target sites to these 2 CCR5 sgRNAs .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10745221

The cells were divided into 500 μL aliquots, which were lysed at 13,000 g at 4°C for 5 min.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells...

PMC11700523

Two-way ANOVA was utilized for statistical comparisons among more than three groups.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two-way", "ANOVA", "was", "utilized", "for", "statistical", "comparisons", "among", ...

PMC11790599

The primer sequences can be obtained upon request.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primer", "sequences", "can", "be", "obtained", "upon", "request", "." ] } ]

PMC11765678

Adriamycin (ADR, >98%) was the gift of the Drug Synthesis and Chemistry Branch, Developmental Therapeutic Program of NCI, NIH.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11590870

Three of the fourteen peptides previously identified have this amino acid within their structure .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "of", "the", "fourteen", "peptides", "previously", "identified...

PMC10926885

In addition, several immunological pathways and activities were linked to NDE1 by KEGG and GO enrichment studies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "several", "immu...

PMC11678841

Given that it is well known that p38 activation is strongly regulated by MAPK kinases MKK3/6 and MAPK-ERK1/2 , Western blotting experiments were performed to evaluate GA ability to modulate these pathways.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11753435

It relies on the enzymatic activity of biotin protein ligase to biotinylate proteins in proximity to a bait of interest.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "relies", "on", "...

PMC8956657

R24A and R33A mutants had the greatest effect on binding.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "R24A", "and", "R33A", "mutants", "had", "the", "greatest", "effect", "on", "binding", "." ...

PMC10890055

The billets were tempered for 10 min in the extrusion die.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "billets", "were", "tempered", "for", "10", "min", "in", "the", "extrusion", ...

PMC11701801

The CASP6 gene in SMARCA4/SMARCA2-deficient cells and SS18–SSX fusion cells was upregulated by simultaneous knockdown of CREBBP and EP300 (Fig. 4E); thus, these results indicate that simultaneous inhibition of CBP/p300 in SMARCA4/SMARCA2-deficient cells and SS18–SSX fusion cells induces apoptosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC3765139

In particular CD133 (Prominin 1), which is expressed on stem and early progenitor cells (CD34+ hematopoietic stem cells) and tumor-initiating cells of several malignancies , is prominent subject of ongoing research.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10490530

As per the supplier’s recommendation, various human cell lines, i.e., HT1080, A2780, and SKOV3, were cultured in DMEM, and the A549 and MCF7 were cultured in RPMI1640 media, supplemented with 10% fetal bovine serum and 1% penicillin-streptomycin solution.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O"...

PMC9813422

This mini review summarizes our current knowledge of the tethering sites of viral episomes, such as EBV, KSHV, and HBV, on host chromosomes analyzed by three-dimensional genomic tools.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6684588

We recently demonstrated the feasibility of using a FST288-based fusion protein to promote dose-dependent, localized growth of skeletal muscle in normal mice without detectable systemic effects.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11532793

Together, these changes result in significant improvements to an already very competitive DTE pipeline.

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PMC9429973

Safety-set includes patients receiving ≥1 dose.

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PMC11519567

The diameter of the bleached area is ~1 μm.

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PMC11594806

Further studies and clinical trials are crucial to validate these findings and optimize therapeutic strategies, particularly for osteosarcoma.

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PMC9429973

Conversely, the rising number of patients with Sickle Cell Disease (SCD) in many European countries has resulted in increased demand for blood transfusion.

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PMC11365427

P value below 0.05 was considered statistically significant.

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PMC9878562

In neoplasms, the chemokine system plays a promiscuous role depending on the type of cancer, the cellular and environmental context, and the involved chemokine axis.

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PMC11371627

CSF flow cytometry revealed a slight elevation of HLA-DR CD4 (27.8%, reference <24%) and HLA-DR CD8 cells (75.5%, reference <63,4%), a CD4/CD8 ratio of 1.4 and an elevation of natural killer cells (NKs) (5,8%) (Figure 2A).

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PMC9429973

ORR/CR were assessed per local investigator according to the Lugano criteria using CT and/or PET-CT.

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PMC7762347

It is known that the formation of micronuclei correlates with DNA double-strand break formation .

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PMC10882807

However, the underlying mechanisms of HCCprogression or metastasis have not been fully elucidated.

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PMC10968586

Among all HT doses tested (1–40 μM), only 20 μM affected viability of THP-1 cells after 72 h .

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PMC11672881

A synergistic cytotoxic effect was observed when piperlongumine was combined with a pancratistatin analog, which activates the intrinsic apoptotic pathway through mitochondrial targeting .

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PMC9739791

Flavins are a group of biomolecules that play a key role in aerobic metabolism, embryonic development, and programmable cell death .

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PMC11763111

We conducted a comprehensive analysis of 4KO-LLT1 CAR-T cells, evaluating cytokine secretion, antigen-specific proliferation, immunophenotyping, and transcriptomic profiling.

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PMC9429973

Mixed donor-recipient chimerism was found in the buccal epithelium of 49 patients with the proportion of own recipient DNA ranging from 11% to 98%.

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PMC8658661

One of the biomarkers of tumor processes in the liver is a change in the level of alpha-fetoprotein (AFP)—plasma protein produced by the yolk sac and the fetal liver during fetal development .

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PMC11730320

A Read alignments for the proband and unaffected parents were visualized using the Integrative Genomics Viewer.

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PMC11782508

Additionally, the presence of sulfur (mass ratio 11.15) likely originates from cysteine (Cys) and methionine (Met) residues.

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PMC11752740

The increased expression of Caspase3 further suggests a heightened apoptotic response .

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PMC11764090

Boosting antioxidant enzymes to clear excess ROS is a key strategy for plants to handle cold stress.

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PMC9429973

Results: Results showed that the percentage of CD16 monocytes in PB and BM was significantly increased in AA patients compared with that in HDs, and the proportion of CM was decreased.

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PMC8633974

First, computational assessments suggest that proviral targeting choices require affirmation in patient-derived HIV-1 isolates.

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PMC11144200

Meanwhile, to reduce the DOX-induced cardiotoxicity and toxicity within various organs like the liver or kidney, liposomal delivery systems were developed to passively target DOX to tumor .

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PMC9429973

Aims: To evaluate the efficacy, safety, and tolerability of magrolimab + azacitidine + venetoclax in previously untreated patients with AML who are ineligible for intensive chemotherapy.

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PMC9429973

Patients (pts) with IBD are at an increased risk of cancer secondary to long-standing intestinal inflammation and secondary to immunosuppressive therapies, including but not limited to colorectal cancer, hepatobiliary tract cancer, Hodgkin, and non-Hodgkin lymphomas.

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PMC7602170

Activated mTORC2 directly activates AKT via phosphorylation at Ser473 and SGK1 (S422), controlling ion migration and cell growth .

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PMC11756514

Bacteria with an OD600 of 0.4 in TBS+ or TBS, 10 mM EDTA, and 0.5% BSA were incubated with decreasing biotin-langerin ECD or biotin-MBL concentrations for 30 min at 37°C.

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PMC11787355

Our TCR-T cell manufacturing process transduced both CD4 and CD8 T cells, and we observed that CD4 TCR-T cells, even without the co-receptor CD8, were activated in an antigen-dependent manner (Supplementary Fig. 6a–c).

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PMC11291697

The figure was created with BioRender (https://www.biorender.com/).

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PMC11541241

They failed to obtain a null mutant in tor1, indicating that TOR was vital in U. maydis.

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PMC9429973

The next important step of this project is to test PK properties in-vivo and validate the promising findings observed in-vitro.

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PMC11640555

All stained sections were observed and analyzed in a blinded manner at an objective lens of 20x and 40x by using a Nikon Eclipse Ci-L microscope.

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PMC11535726

Prior to the incorporation of molecular data, the taxonomy of Kirschsteiniothelia was challenging, resulting in controversial classifications.

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PMC11478724

The cells were allowed to incubate for 2 min, following which the supernatant was removed.

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PMC11514418

This substance is commonly used for the conditioning of malignant tumors in TCM.

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PMC11791264

SETD7 methylates LC3B at K51 and promotes LC3B ubiquitination and degradation, resulting in reduced formation of autophagosomes.

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PMC11721064

β-actin or glyceraldehyde-3-phosphate dehydrogenase (GAPDH) served as loading controls.

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PMC9429973

Pharmacodynamic reporting will focus on HbF changes.

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PMC11371627

Dominant features at presentation were raised CK, muscular weakness and atrophy, decreasing physical performance and exercise intolerance which the patient had only noted after COVID-19 disease.

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PMC7215722

Here we could show that Caco-2 cells exposed to DSS treatment exhibit an upregulation in the transcriptional levels of IL-1α, IL-6, and TNFα cytokines, accompanied by a downregulation in the transcription level of the anti-inflammatory cytokine IL-10.

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PMC10033453

Tumor volume was measured three times weekly until humane endpoint or end of study (day 14). (

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PMC11699465

TMEM199 also mediates the early stage of influenza A virus infection.

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PMC9429973

Normal Hb levels achieved within 61 days after a transfusion were excluded.

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PMC4695073

The threshold cycle (Ct) values were detected and normalized against that of β-actin internal control.

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PMC6163708

More than half of tumor cells were sensitive to GANT61 to various extents.

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PMC9812014

VSV is a zoonotic arbovirus that is related to rabies viruses and belongs to the Rhabdoviridae family.

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PMC11670954

However, following LPS treatment, trans-epithelial electrical resistance (TEER) decreases, while FITC-dextran permeability increases, and the expression levels of Occludin, ZO-1, and Claudin5 decrease .

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PMC10975211

The bioconjugation of buforins with various entities, such as nanoparticles, antibodies, or targeting ligands, aims to improve their pharmacokinetics, biodistribution, cell-specific delivery, and targeting of cancer cells .

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PMC10452486

Garrido , in a book titled “MHC class-I loss and cancer immune escape”, categorized the loss of HLA-Ia in human cancer into several groups, as follows: Type 1:Tumor cells can lose all of the six HLA-I alleles present in the normal cells;Type 2:Tumor cells can lose a single HLA haplotype or one set of HLA-Ia genes localized on chromosome 6 (HLA-A, B, and C);Type 3:Tumor cells can downregulate an HLA-A, B or C locus, producing a phenotype with only four HLA-Ia alleles,Type 4:Tumor cells can lose a single HLA-I allele out of the six expressed by somatic cells;Type 5:Tumor cells can lose HLA-Ia (classical) alleles and upregulate the expression of HLA-Ib (non-classical) haplotypes, namely HLA-E, HLA-F, and HLA-G), primarily based on the correlation between the loss of HLA-Ia, concomitant with the upregulation of HLA-Ib.

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PMC9429973

We report here long-term outcomes with a median follow-up of 56.8 months.

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PMC6889484

Cells were washed to remove PHA-P, and CD4 T cells were isolated using the Dynal CD4 Positive Isolation Kit (Invitrogen).

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PMC11753435

Plates were read on a microplate reader (Tecan).

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PMC11476222

The RT range (min) was set to ±0.5.

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PMC9429973

One patient with BCS died.

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PMC10873328

The mRNA expression level of TGFBI, AKAP12, GPC1 and TGM2 after transfected with HIF1a-plasmid. (

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PMC9985266

In conclusion, our results show that IL-27 can inhibit DNMT1-mediated methylation of the MEG3 promoter, thereby upregulating MEG3 expression.

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PMC11703896

For the first time, the current study reported that rapamycin has a binding affinity with ALK, EGFR, FGFR, MET, and ROS1 receptors expressed in the lung cancer cells.

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PMC9031474

Interestingly, structurally related eudasmane sesquiterpenoids and meroterpenoids lead to the attenuation of NF-κB dependent pathways .

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PMC11476004

When these errors are not prepared or improperly repaired, they negatively affect the stability of the genome.

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PMC11650848

Cognitive outcomes were assessed using the Wechsler Intelligence Scale for Children 4th UK Edition (WISC-IV), with neural activity during language tasks quantified using magnetoencephalography (MEG).

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PMC11743414

The effects of silencing and overexpression were evaluated by qRT-PCR and Western blot.

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PMC11739484

Transfected A375 cells were seeded in 96-well plates at a density of 3000 cells per well.

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PMC10944868

However, despite tubulin inhibitors have demonstrated significant efficacy in the treatment of cancer, it is important to note that tubulin inhibitors are not specific to cancer cells and can affect healthy cells that divide rapidly, such as bone marrow and gastrointestinal cells.

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PMC9429973

TAFA is a humanized CD19-directed cytolytic monoclonal antibody that contains an IgG1/2 hybrid Fc domain with 2 amino acid substitutions to modify the Fc-mediated functions of the antibody and mediates B-cell lysis through apoptosis and immune effector mechanisms.

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PMC11694066

Because several PARPi plus ATRi combinations are currently being investigated in early-phase clinical trials (e.g., NCT04972110 and NCT03462342), we evaluated this combination in DSRCT cell lines.

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PMC11306331

Constructs were cloned with InFusion (Clontech) using backbone PCR.

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PMC11371747

Indeed, clinical studies also showed a relation of 5FU-LV efficacy with FPGS expression (Chazal et al., 1997; Cheradame et al., 1997).

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PMC9429973

The primary endpoints were response to therapy (hematological, PET, VEGF and clinical, which will be referred to as responseH, P, V, C, respectively), and time to next therapy (TTNT), defined as time from institution of regimen of interest to next therapy.

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PMC9429973

The most common non-hematological toxicity events were nausea, fatigue and anorexia.

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PMC11747467

J, K) In ERBB2-silenced luminal cells and ERBB2-overexpressing basal cells, Western blot analysis was performed to measure the expression changes of ERBB2, STAT3, and pSTAT3 (Tyr705). (

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PMC11612315

Mechanical allodynia was assessed via von Frey filaments (NC12775-99; North Coast Medical, CA).

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PMC11585565

The analysis of the wild-type and mutant CNNM4 proteins was the same as the analysis of mRNA decay, however, the wild-type and mutant CNNM4 protein levels were normalized to the GAPDH protein level.

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PMC7452526

Amino acid can also reduce and bind silver ions through amino and carbonyl groups .Figure 1UV–Visible absorption spectrum of the synthesized silver nanoparticles at different times (10, 30, and 120 min).

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