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PMC11791203
These findings align with observations reported by Rello et al., where various apoptotic treatments applied to HeLa cells caused significant alterations in cellular morphology, including rounding, shrinkage, and pronounced plasma membrane blebbing, as visualized via SEM, 72 h after etoposide treatment.
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PMC6684588
Follistatin is a naturally-occurring protein that acts as an extracellular trap to regulate biologic activity of the aforementioned TGFβ superfamily ligands.
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PMC7685376
Hence, given the important role of the MCM family in tumorigenesis, we suggest that MCM proteins are the key targets of Huaier treatment for HCC.
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PMC11186948
Finally, pathogenetic variants in HDAC8 are causative of Cornelia de Lange syndrome 5 (CdLS5, OMIM #300882), whose patients show growth impairment, ID, multi-organ anomalies and peculiar facial features (Deardorff et al. 2012a; Kaiser et al. 2014; Parenti et al. 2016).
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PMC6337547
Caffeic acid can inhibit platelet-mediated thrombosis.
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PMC11705630
Lentivirus for overexpression of GLDC (OE GLDC) and corresponding control vector (EV) were purchased from Addgene, MA, USA.
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PMC10142392
The use of nanocarriers for drug delivery arose from the need to find new vehicles for bioactive agents that would provide pharmacokinetic profiles that mimic the normal pattern of these agents, when the therapeutic efficacy of many of these agents is limited by the therapeutic index and selectivity .
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PMC6133382
This gp120 A244 had the sequence point mutations E332N and N334S, introducing a PNGS at N332.
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PMC11515150
We produced up to 4442 fold expansion of CAR-NK cells within 19 days of culture (Fig. 5a).
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PMC11286266
B.1) Cell lysates from 2K cells and four independent 2K-CRT∆ derivative clones were harvested, immunoprecipitated (IP) using GFP-Trap Agarose (ChromoTek) and analysed by immunoblot (IB) using an anti-FLAG M2 antibody to detect processing of ATF6α.
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PMC9429973
The LyV4.0 CAPP-Seq assay that comprised a panel of 59 genes relevant to B-cell malignancies was used.
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PMC11063646
Fig. 10% Cells expressing FITC signal in untreated and FG-FITC (ANG 12) treated A431 cells at different intervals.
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PMC9429973
Long-term engraftment of T-cells from cryopreserved, disease-bearing BM from patients is feasible and may allow e.g. testing of T-cell recruiting agents such as bispecific antibodies or CAR T cells.
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PMC11792888
Rhopalurus junceus (R. junceus) is one of Cuba’s most widespread endemic scorpion species, and its venom has long been used in popular Cuban traditional medicine.
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PMC10589262
Western blot analysis showed that GIST cells exclusively and constitutively expressed the cleaved form of ATF6 (cATF6), which is a transcriptional activator that upregulates the expression of chaperones and cell survival-related genes (Fig. 4A).
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PMC7305184
It has been successfully translated from in vitro studies into clinic.
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PMC11740508
We tested for increased DNA damage signaling by counting phosphorylated histone H2A.X (p-H2A.X) foci in our isogenic M231 cell lines and in SUM149PT control cells over a 4 day time course.
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PMC11802929
The strong-binders indeed exhibit a relatively higher polarity and a lower hydrophobicity relative to all attempted A*02:01 SCT constructs (Supplementary Fig. 4c).
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PMC7369657
Proapoptotic proteins, for instance Bax and Bad, help in allowing passage of the mPTP (mitochondrial permeability transition pore).
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PMC10421378
It plays a crucial role in the interaction between the probiotic cells and the gut of the host.
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PMC10938336
Within this network, nodes represent proteins, while edges denote interactions between them.
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PMC11001582
Silent and hyperactive neurons were defined as those with individual activity rates of 0 and >3 transients per min, respectively.
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PMC11218145
Both in vitro and in vivo results confirmed the effect of TB on MPM and unravelled novel targets with translational potential.
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PMC11781181
The HaCaT cell lines were cultured in a medium with Dulbecco's modified Eagle's medium (DMEM) and fetal bovine serum (FBS) at 37 °C with 5% carbon dioxide.
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PMC8097906
c Alterations of the cytoskeleton of RH-30 cells after 25 μg/ml VSM treatment for 48 h compared to the DMSO (0.1%) treatment control.
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PMC10812665
For sample preparation, LUHMES cells were lysed in Laemmli buffer and boiled at 95 °C for 5 min.
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PMC10387886
In the current study, TGFβ1 supplementation increased DUSP7 and reduced DUSP8 expression in SKOV3 cells.
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PMC11755467
Enoxacin, a member of this compound class, did not show any protective effect in MT-4 cells, but showed a cytoprotective effect in the T-cell line CEM revealing that this effect of Enoxacin is cell-type dependent .
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PMC11271278
These events often cause extensive alterations of enhancer-promoter interactions, posing another challenge to characterize the underlying mechanisms of oncogene regulation.
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PMC9429973
CDK6 ChIP experiments confirmed that INK4 binding alters binding of CDK6 to the Id1 promoter, which is significantly reduced in CDK6 cells.
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PMC11604830
In vivo PRESS of PLNs acquired 24 h post PFCE‐NE injection in the footpad.
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PMC9080589
Down-regulation of E-cadherin expression is usually associated with advanced stage and progression.
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PMC9429973
Patient 1 and patient 2 received MRD negetive CR at day 14 and 21, but patient 2 relapsed at day 43 after first round infusion.
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PMC9429973
Aims: To investigate the role of autonomous BCR signaling on constitutive VLA-4 activation state in CLL.
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PMC11036064
The phosphorylation of tyrosines Y1349 and Y1356 on the c-MET activates the Ras-Raf-MEK-ERK pathway, leading to activation of the cell cycle, regulation of matrix metalloproteinase expression, and invasion in malignant cells (Abounader and Laterra, 2005).
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PMC11519583
MP proliferation was significantly higher in glycerol-injected TA muscles than in Ctx-injected muscles (Fig. 3h, i).
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PMC11658074
Moreover, the NIH3T3 cells in the AT-EV group expressed more CD151 (Fig. 6b, d).
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PMC11045125
EBV+ BLs are particularly common in children living within the “malaria belt” region of Africa, and there is evidence that malaria infection cooperates with EBV infection to promote these tumors .
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PMC5363531
Three human MPM cell lines (MSTO-211H, NCI-MPP89, and REN) were used: MSTO-211H (designated MSTO) and MPP89 were purchased from Interlab Cell Line Collection (Genova, Italy), while REN cells were kindly provided by Dr. Moro (University of Novara, Italy) and Dr. Albelda (University of Pennsylvania, Philadelphia, USA).
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PMC11092382
Using two types of injury models (dimethylnitrosamine injection and bile duct ligation), sophocarpine was found to suppress hepatic fibrosis and inhibit the activation and proliferation of hepatic stellate cells (Qian et al., 2014).
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PMC11012313
To determine if LMP2A requires phospho-4E-BP1 to increase HIF-1α levels, we added Sapanisertib to block the generation of phospho-4E-BP1 in LMP2A-negative and -positive cell lines.
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PMC10006224
For experiments labeled in blue in Supplementary Table 4, cells were pelleted and lysed in lysis buffer (1% SDS, 10 mM EDTA, 50 mM Tris-HCl pH 8.1) at a concentration of 2 × 10 cells/ml.
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PMC11265931
The day after, cells were treated with 60 μg/mL of garlic exosome.
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PMC11670407
To test this hypothesis, we assessed the levels of total ROS (DCFH-DA) and mitochondrial ROS (Mito SOX) in osteosarcoma cells.
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PMC11676674
The findings indicate a significant reduction, by 36%, in micronuclei frequency of cells treated with C. monspeliensis extract at the concentration of 50 μg/mL compared to cells treated with MMC alone.
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PMC11351758
Our research group hereby hypothesizes that mitochondrial calcium [Ca]m overload modulates high glucose toxicity on respiratory chain defects in NARP cells.
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PMC10993311
A recent study showed that obesity reshapes visceral fat-derived MHC I associated-immunopeptidomes and generates antigenic peptides that drive CD8+ T cell (Chen et al., 2020).
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PMC11267830
b Cell growth was assessed after 72 h of treatment with indisulam using a CCK-8 assay.
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PMC11787355
Collectively, we found that PTPRZ1 expression positively correlates with AC-like and OPC-like glioblastoma states and glioblastoma stemness, and that its robust expression results in a high MHC ligand load in glioblastoma.
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PMC11806182
The Mendelian randomization (MR) analysis revealed a significant positive association between AURKA eQTL SNPs and PCOS (Fig. 6A).
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PMC11748335
TPM: transcripts per million.
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PMC11224020
Data were analyzed by one-way analysis of variance (ANOVA) with a Kruskal–Wallis multiple comparison analysis; **P = 0.0059; **P = 0.0039.
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PMC11767817
Our previous studies have shown that BF2–curcumin complexes, such as fluorinated , PEGylated , and morpholinated curcumin derivatives, exert a more potent cytotoxic effect than the unmodified β-diketone counterpart.
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PMC4277423
Fig. 6C shows that the 1∶9 ratio of CCR5 and CCR5 cells at both day 6 and 18 post-infection with the X4-tropic HIV-1 Bru3 was maintained (middle panel), similar to uninfected cell mixture (left panel), although infection resulted in down regulation of CD4.
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PMC11721295
Next, we treated LC3-547 cells grown in media containing dox with DMSO, MRTX, or Soto to obtain tumor-conditioned media (TCM) from all treatment groups (ON, MRTX, Soto) for multiplex ELISA (Luminex) analysis.
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PMC8469018
To demonstrate the importance of DHODH, cells were incubated simultaneously with teriflunomide and uridine.
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PMC11656657
This specificity highlights the unique immunomodulatory capabilities of the 143B OS cell line, making it a critical model for studying the mechanisms responsible for MDSC expansion in the TME.
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PMC10932641
The siNC dilution, oeNC dilution, and Lipofectamine dilution were mixed thoroughly and added to 786-0 culture wells (the methods are the same as those of the siGPRC5D-AS1 group). (
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PMC11768281
CD4+ T cells: Addressed in 47.6% (30/63) of studies, these cells play a key role in orchestrating immune responses, particularly in the erythrocytic stage of malaria.
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PMC11055443
The apoptosis rate of Caco-2 cells was % 3.1 ± 1.63, which in the treatment with 5×10 CFU V. cholerae reached to %45.58 ± 1.16 (P <0.0001).
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PMC10907726
As shown in Fig. 7A and B, the results from Western blotting and qRT-PCR demonstrated that DATS treatment decreased the expression levels of EGFR, p-ERK/ERK, p-AKT/AKT and p-mTOR/mTOR.
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PMC10243817
High-throughput sequencing of the libraries was performed on an Illumina NextSeq 500 system using 150 nt paired-end sequencing by ABLife Inc. All clean reads were then mapped to the human GRCh38 genome using TopHat (v2.1.1).
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PMC11545737
Other members of the gasdermin family, such as the GSDMA, GSDMB, GSDMC and GSDMA3 (whose genes are present in the mouse but absent in the human genome), have pore-forming and pyroptotic activity .
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PMC9878278
Whole-cell extracts from uninfected and infected SC transfected with siCtrl, and siRIG-I (exon 11) at 48 hpi with ZIKV were subjected to Western blotting and stained for p-IRF3 and β-actin. (
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PMC11401350
The elimination of CD4 + T cells was more robust upon TCR activation than IL-7 /IL-15 stimulation.
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PMC11676674
There is a general belief that plant medicines are safe based on their long-term application; however, some plants used in traditional medicine may also possess genotoxicity .
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PMC11367146
The docked complex BCL2-daucosterol formed a maximum number of intramolecular hydrogen bonds in the range of 0–16.
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PMC11023271
The mechanism of this down-regulation was investigated in vitro using the immortalized but non-tumorigenic keratinocyte cell line, HaCaT. The authors found that scratch wounding led to a reduction in RIPK4 mRNA in these cells, as did serum and some growth factors.
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PMC2193049
Samples used in subsequent CTL assay included 100 pmol peptide and 4 μg purified proteasome.
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PMC9250505
into the right flanks of five-week-old female BALB/c nude mice (Charles River, Beijing).
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PMC7351993
Highly lipid-rich, but rare (only 0.3% of the total population) Chlamydomonas sp. mutants (indicated by the yellow region) were sorted by the RIACS.
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PMC9429973
Before first chemotherapy administration, spontaneous WBC reduction was observed (6.730/mm).
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PMC11772449
n= 3, *P<0.05; **P<0.01; ***P<0.001) PFD combined with Sora can down-regulate the level of autophagy in HCC cells.
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PMC9429973
WD repeat domain 5 (WDR5) is essential for the methyltransferase activity of MLL1 complex and plays an important role in various biological functions.
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PMC9646302
Subsequently, a 20-μl pipette tip was used to scratch along the previously marked line on the back of the plate.
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PMC11350568
By leveraging a novel combination of a bivalent aptamer glue and a protein transport shuttle, we demonstrated the system’s ability to effectively degrade the protein tyrosine kinase 7 (PTK7) in CCRF-CEM cells and target lowly expressed PTK7 in MV-4–11 cells.
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PMC11711127
CD8+ regulatory subsets have also been reported, though have received far less attention.
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PMC11489351
Low pHi: complete media supplemented with 25 μM EIPA (Invitrogen, E3111) (MCF10A) or 30 μM S0859 (Millipore Sigma, SML0638) (MCF10A, RPE), or a combination of 1 μM EIPA + 30 μM S0859 (MDCK).
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PMC6892818
ACHN, 786-O and A-704 cells treated with mCD40L for 24 h in the absence of inhibitor (vehicle controls) were also included (denoted as positive control, ‘PC') for each experiment.
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PMC11638288
During endoplasmic reticulum (ER) stress, it is transported from the endoplasmic reticulum to the cell membrane.
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PMC9118379
With the first four examinations, we seek to detect dubious PSMs caused by searching an incomplete protein sequence database or neglecting possible modifications; they are designed with increasing search spaces of peptides and modifications, i.e., (1) < (2) < (3) < (4).
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PMC11352311
Among these, GAPDH had the highest degree (degree of 16), while CA12 and PIM1 had the lowest (degree of 1).
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PMC11770130
The information on key reagents involved in this study was presented in Supplementary information, Table S13.
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PMC11395280
Flow Cytometry Assays.
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PMC6835428
In vivo, in an orthotropic model of OC, obtained using SKOV3 expressing the luciferase gene (SKOV3-luc), it was observed that when injected IV (35 μg of siRNA), the particles had short circulation half-lives.
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PMC11576293
1.
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PMC9964654
UV-Vis spectrophotometry was performed on a Cary 60 UV-Vis spectrophotometer from Agilent Technologies with quartz cuvettes (QS high Precision Cell; 10 mm (Hellma Analytics, Jena, Germany)), and TBA[Au(cdc)2] was quantified with reference to a calibration curve.
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PMC8193046
After a confluence of 90% was reached, the cells were harvested using a 0.05%/0.02% trypsin-EDTA solution (PAN-Biotech GmbH, Aidenbach, Germany).
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PMC9917080
The average size of the nanoparticles is about 100 nm, the half-width is in the range of 70–130 nm.
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PMC11476222
This leads to an increased ability to separate isomers such as GD1a and GD1b.
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PMC6222726
They compared the activity of deoxypodophyllotoxin (15), podophyllotoxin (19), and yatein (17) against six human cancer cell lines: A549, U373 (glioblastoma), T98G (glioma), Hs683 (oligodendro-glioma), MCF7 (breast cancer), and SKMEL-28 (melanoma).
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PMC11279397
It demonstrated dose-dependent inhibition of influenza virus A/PR/8/34 (H1N1), while showing no activity against influenza virus A/54/89 (H3N2).
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PMC11240448
Hierarchical clustering of this heatmap (see dendrograms) suggests that the BMRA-inferred core networks for the analyzed basal BC cell lines can be roughly classified into four distinct groups based on the immediate drivers of their oncogenic transformation.
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PMC9841531
Molecular docking was conducted as described earlier by applying Chimera version 1.10.2 with the Autodock vina 1.1.2 software in conjunction with the PyRx Virtual Screening Tool 0.8 and the Biovia Discovery studio.
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PMC11025866
VPM, the amide derivative of VPA, can be metabolized to VPA in the liver, but there are still distinct properties of VPM .
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PMC5916734
In fully active FIX, the first 10 Glu residues out of the 12 need to be converted into Gla residues.
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PMC5386478
Western blot analysis was performed on the cell lysate with peroxidase-conjugate streptavidin and ECL reagent.
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PMC11672617
These compounds, which we have designated as “soft dissociators”, exhibit enhanced biopharmacological properties relative to the original lithocholic acid molecule.
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PMC11352746
This optimization process was observed in three of these publications.
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PMC11655498
This allows for the establishment of latent infection, as the virus can remain dormant within host cells.
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