OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11727062	Consequently, this inhibition of glycolytic enzymes contributes to the suppression of cellular drug resistance development (Jalal et al. 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ...
PMC5386478	For generation of multicellular spheroids, 5 × 10 cells were added into each well of polyHEMA-coated 96-well plate and placed in a 37 °C humidified incubator with 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: Therapy related mortality remained high and EFS and OS has a trend for improvement compared with previous published papers from the same centre.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11343332	Following that, the cells were maintained at 37° in the CO2 incubator for 4 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "that", ",", "the", "cells", "w...
PMC11740907	Table 3 demonstrates that the creation of microemulsion was unsuccessful in cases where a surfactant combination was not used (F1-P5W30-BW-SLNs and F3-P5W30-BW-SLNs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10297204	STSs arise in proximity to the sciatic nerve .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "STSs", "arise", "in", "proximity", "to", "the", "sciatic", "nerve", "." ] } ]
PMC11745823	Furthermore, RIT1 serves as an independent prognostic marker of poor prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "RIT1", "serves", "as", "an", "independent", "prognostic", "m...
PMC9351137	Bars with different dashed lines indicate SRCAP complex-specific subunits (CFDP1) or p400/Tip60-specific subunits (p400 and Tip60).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bars", "with", "different", ...
PMC10470467	p < 0.01; ***p < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.01", ";", "", "", "*", "p", "<", "0.001", "." ] } ]
PMC11758416	To address this, culture T cells with IL-15 or IL-7 during the pre-stimulation step.•Include a positive control of CD8 T cells with expected cytotoxic function to ensure a successful assay was performed.•Periodically stain the CD32-expressing L cells for CD32 to ensure expression is not lost.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In all patients, the first mutational hit occurred on epigenetic remodeler genes (i.e. TET2, ASXL1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "all", "patients", ",", ...
PMC9429973	The endoscopic appearance was an ulcero-budding process in 59.5% of cases, gastric infiltration (9.5%) and a large folds or polyploid mass (7%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11673128	At the forefront of innate immunity, targeting tumor-associated macrophages (TAMs) within the tumor microenvironment (TME) has been considered a promising immunotherapeutic strategy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10933092	Green represents lncRNA, red represents mRNA, blue represents miRNA, and pink represents reported miRNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Green", "represents", "lncRNA", ",", "red", ...
PMC11697189	Kaplan-Meier curves of overall survival (OS) for ccRCC in three clusters. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kaplan-Meier", "curves", "of", "overall", "survival", "(", "OS", ...
PMC11609529	ES-2 cells were seeded at 500 cells per well in 12-well plates and treated with CA3 or VPF at the indicated concentrations (n = 3, mean ± SD).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11592837	To compare the time series of cfDNA formation between PBMCs and Jurkat cells, fragments of nuclear (Alu 115 bp and Alu 247 bp) and mitochondrial marker (MTCO3 67 bp and MTCO3 296 bp) were quantified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6450504	After filtration, PEIPOS were characterized by size, polydispersity index (PdI) and zeta potential (ZP) by dynamic light scattering (DLS) in a Zetasizer Nano ZS 90 (Malvern Instruments, UK), with the samples previously diluted with ultrapure water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11448304	Radioresistance contributes to metastasis and recurrence in non-small cell lung cancer (NSCLC) patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Radioresistance", "contributes", "to", "metastasis", "and", "recu...
PMC9429973	However, significant reduction in HsCRP, procalcitonin and ferritin pre and post CPT was found.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "significant", "reduction", "in", "HsCR...
PMC11585994	Agarose gel electrophoresis determining the optimal G5 to nucleic acid (N:P) ratio in the nanoparticles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Agarose", "gel", "electrophoresis", "determi...
PMC11718109	Scale bar, 10 μm; inset: 2.5 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "10", "μm", ";", "inset", ":", "2.5", "μm", "." ] } ]
PMC8316344	C TRIB2 knockout prolonged while TRIB2 overexpression shortened the half-life of TFRC protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "TRIB2", "knockout", "prolonged", "while", "TRIB2", "overexpression", "...
PMC10142392	In addition, one approach to accessing ABC-type multi-arm structures involves using a low molecular weight initiator that has a free hydroxyl group, along with an ATRP initiator branch (such as bromobutyrate) and an NMP initiator branch (such as TEMPO alkoxamine).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11173119	Familial Mediterranean fever (FMF) is a systemic autoinflammatory disorder caused by inherited mutations in the MEFV (Mediterranean FeVer) gene, located on chromosome 16 (16p13.3) and encoding the pyrin protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9370419	Third, the cells were lysed using the HiBiT Lytic Detection System after 12 h. Ten minutes after the lysis, the level of HBx was measured by the level of luminescence (Figure 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8348645	Then, the protein expression of BAX and BCl2 was studied using fluorescent dye to determine the regulation of the BAX and BCl2 genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC7840816	The data indicate that upregulation of SOX9 favors PTC progression and metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "indicate", "that", "upregulation", "of", "SOX9", "favors", "PTC",...
PMC9429973	No thrombotic or cardiovascular complications occurred during follow-up.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "thrombotic", "or", "cardiovascular", "complications", "occurred", "during", "follow-up", "." ] } ]
PMC9219615	To distinguish between apoptotic and necrotic cell death, we performed an Annexin V-FITC/PI assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "distinguish", "between", "apoptotic", "and", "necrotic", ...
PMC9429973	To identify BCL-2+ tumor cells an immunohistochemical staining method was used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "identify", "BCL-2", "+", "tumor", "cells", "an", "immunohistochemical", "s...
PMC9429973	Summary/Conclusion: T22-PE24-H6 selectively kills AML cell lines and BM samples from AML patients with CXCR4 overexpression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "T22-PE24-H6", "selectively",...
PMC11345828	However, the 2-carboxy-1H-indol-7-yl motif allows for functionalization of the indole 4- and 5-positions, which were further examined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "2-carboxy-...
PMC10237474	Expi293F cells were seeded to a total number of 75x10 in 30 mL of Expi293™ Expression Medium and grown to 3x10 cells/mL density with a viability >95%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11301242	European Nucleotide Archive and Sequence Read Archive were queried for WGS or CIRCLE-seq data on hematologic malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "European", "Nucleotide", "Archive", "and", "Seque...
PMC11116779	Collectively, this investigation underscores the importance of concentration (dose-dependent effect) and exposure duration as pivotal factors in assessing the toxic effects of PS-NPs on alveolar epithelial cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11321678	Previous reports showed SHH MB cells can transdifferentiate into IL‐4‐secreting astrocytes, which induce microglia to release IGF1 and IL‐10, both crucial for tumor progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11593084	The tumor volume was measured on the indicated days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "tumor", "volume", "was", "measured", "on", "the", "indicated", "days", "." ] } ]
PMC11779876	Mechanisms of primary resistance might be at work which warrant further investigation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mechanisms", "of", "primary", "resistance", "might", "be", "at", "work", "which"...
PMC9429973	Wells with individual clones had been analyzed further.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Wells", "with", "individual", "clones", "had", "been", "analyzed", "further", "." ] } ]
PMC9429973	However, pts unable to undergo HDCT/HSCT have limited treatment options and often have poor outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "pts", "unable", "to", "undergo", ...
PMC11599565	In addition, the neuronal morphology was rapidly established when commercially available and primary ovarian carcinoma cells were cultured in the form of organoids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC10443665	For the resistant cell line (CCRF-CEM/R) same procedure was repeated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "resistant", "cell", "line", "(", "CCRF-CEM/R", ")", "same", ...
PMC9429973	Results: Enrollment in this study has begun in Europe.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Enrollment", "in", "this", "study", "has", "begun", "in", "Europe", "." ...
PMC5839394	The AgNPs-EPS is more active than AgNPs-EPS, with SKBR3 and 8701-BC cell lines being more sensitive to AgNPs-EPS treatment in comparison to HT-29, HCT 116 and Caco-2 colon cancer cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O"...
PMC11743316	The anti-apoptotic protein BIRC3 serves as one of several inhibitors of apoptosis proteins that are necessary for preserving cell survival, and prior research has demonstrated that CRL4 mediates OC chemoresistance by targeting this protein .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11672881	For Annexin V staining, cells were grown in 60 mm plates until reaching 90% confluence, treated with 25 µM curcumin, 10 µM thymoquinone (TQ), or their combination, then trypsinized and counted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Molecular diagnosis of β-thalassemia was performed by automatic Sanger sequencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Molecular", "diagnosis", "of", "β-thalassemia", "was", "performed", "by", "automatic", "Sanger", ...
PMC11574271	Identification of MMP12 prompted us to study whether RON-mediated bladder cancer cell invasive growth is channeled through this functional protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Identification", "of", "MMP1...
PMC6163708	We can speculate that higher doses of GANT61 or a prolonged time of treatment would have a better effect in eradicating tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", ...
PMC8633974	The HIV-1 proviral genomes isolated from elite controllers display large deletions of env sequences flanked by tat/rev amongst other regulatory genes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "HIV-1", "p...
PMC11218145	injection.	[ { "tags": [ "O", "O" ], "tokens": [ "injection", "." ] } ]
PMC11422150	Suppressing activated macrophages/microglia may improve tissue damage and facilitate functional recovery in SCI (Tian et al., 2007; Popovich et al., 1999).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9325715	The complex also was characterized by numerous techniques: spectrometric (ICP-MS), spectroscopic (UV–Vis, ATR-FTIR), electron microscopy (TEM–EDX), SDS-PAGE.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11540664	Thus, our results suggest that peripheral blood lymphocyte count can be used as a biomarker to identify patients with liver cancer who will benefit from TKI+PD-1 combination therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11715644	Whereas researchers have previously studied collective cell migration in defined confinement, how cells collectively negotiate and move from unconfined to confined matrices remains unclear.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10965315	These findings suggest that harmaline may have the potential to be a therapeutic drug for ovarian cancer by triggering apoptosis and suppressing invasion and migration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11714165	Comparing the DN‐F group with the control groups, it was evident that bone parameters, such as bone volume, bone surface area, trabecular number (Tb.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10589262	By targeting mutant KIT expression itself, HSP90 inhibitors offer a promising approach for GIST treatment that may overcome imatinib resistance mechanisms associated with secondary mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11541409	In a phase IB/II study (NCT04138381) involving imatinib-resistant GIST patients, the toxicity of selinexor was manageable, clinical benefit rate (CR + PR + SD) ≥ 16 weeks was 42% (95% CI: 0.181–0.685) in cohort A (n = 12, imatinib 400 mg/day, weekly selinexor) and 28% (95% CI: 0.213–0.354) in cohort B (n = 18, selinexor 60 mg twice weekly) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10747160	For the Griffithsin pre-incubated with 3t3 cells protocol, 50 μL stock dilution of each requisite Griffithsin variant (WT-Grft, Q-Grft, GLG-3A) was prepared in PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11530949	Additionally, the FTIR picture of the Ag-doped CuO NPs shows strong, distinct peaks in the range of 1123.26, 1452.30, and 2832.19 cm-1 that are associated with C-H plane bending vibration, CH3 symmetric bending, CH2 stretch vibrations, and OH stretch.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683240	These severe pathologies are PT-mediated, and risk factors associated with death (39, 40, 41, 42).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "severe", ...
PMC10926885	The material transported by microtubules is very rich; mRNA, organelles and vesicles are just a few of the intracellular molecules that dynein transports.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11488203	Transfection of three different MSC populations with miR-454 and subsequent quantification of SDF-1 production by a corresponding ELISA, however, demonstrated little if any effects on the SDF-1 production of either MSC population (suppl.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11763111	As ready-to-use therapeutic products, they offer promising treatment options for various hematological malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "ready-to-use", "therapeutic", "products", ",", "they", "offer", ...
PMC10547921	Compared to tubulin inhibitors, DNA inhibitors can act on the whole cell cycle by destroying DNA through double-strand breakage, alkylation, chimerism, crosslinking, etc.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2614415	The sub G0/G1 population represents apoptotic cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sub", "G0/G1", "population", "represents", "apoptotic", "cells", "." ] } ]
PMC11472639	Myeloma patients in remission (MREM) were also recruited to preliminarily explore how a single bout of exercise affected immune cell frequency, including clonal plasma cells, in blood of patients in remission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9559528	Additionally, this patient should have also been tested for concurrent Gonorrhea and Chlamydia sexually transmitted infections.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "this", "patient", "should", ...
PMC9318744	GAPDH was used as an endogenous control gene (sense 5′-TCCTCCACCTTTGACGCT-3′ and antisense 5′-TCTTCCTCTTGTGCTCTTGC-3′).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GAPDH", "was", "used", "as", "an", "endogenous", "control",...
PMC10253973	One experiment used transgenic mouse cells that contained human colonic adenocarcinoma cells (LS174T).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O" ], "tokens": [ "One", "experiment", "used", "transgenic", ...
PMC11089031	In ccRCC, the expression of ZNF692 was significantly higher in tumor tissue than in adjacent normal tissue, and the expression of this gene was associated with more advanced cancer stage and poor prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7887261	b Increased DNA damage (γH2AX) levels in five out of the six genes knockdowns (mean ± SEM, n = 2~4), MLNR, CHEK2, POMC, ATM, and MME, compared with non-targeting (NT) siRNA control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10213199	Larvae group, KEGG pathway enrichment analysis was conducted and showed that various metabolic pathways were downregulated (Fig. 2, Fig. 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11731161	Statistical analysis was performed using Prism 8.0 (GraphPad Software, La Jolla, CA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "was", "performed", "using", ...
PMC9919300	More people are expected to be affected in the coming years , and NAFLD represents a problem of both global health and the economy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10329237	Cell viability assay Cell viability was examined by the MTT assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "viability", "assay", "Cell", "viability", "was", "examined", "by", "the", "MT...
PMC11471157	Organization of cell spheroids by HaCaT cells and NIH/3T3 cells on Day 3.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Organization", "of", "cell", "spheroids", "by", "HaCaT", "cells...
PMC11789597	Tests were performed using GraphPad Prism software (Version 9, GraphPad Software, La Jolla, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tests", "were", "...
PMC11257988	Once activated, RAS interacts with multiple effector transcription factors and activates the mammalian target of rapamycin (mTOR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Once", "activated", ",", ...
PMC11733919	However, limited components of the senescent surfaceome were comprehensively and functionally characterized and validated as universal cell surface markers in numerous senescent cell types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11739504	EV indicates empty vector (pCMV-tag2B) and FL-Kat2b indicates full length Kat2b-pCMV-tag2B. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EV", "indicates", "empty", "vector", "(", "pCMV-tag2B", ")", "an...
PMC8777939	For the invasion assay, all steps were the same as those described above, but the incubation time was 36 h. For the scratch wound-healing assay, A2780 and A2780-ADR cells (5 × 10 cells/well) were seeded into six-well plates and scratched with a 1 mm scratch tip (SPL Life Sciences, Pocheon, South Korea) when the cells reached 90% confluence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9985266	Autophagy is an intracellular degradation pathway that is essential for cell homeostasis and is evolutionarily conserved .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Autophagy", "is", "an", "intracellular", "degradation", ...
PMC11411131	The N-terminal signal peptide regions were deleted from the expression constructs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "N-terminal", "signal", "peptide", "regions", "were", "deleted", "from", "the", ...
PMC9429973	Aims: This analysis focuses on normalization of Hb levels in pts treated in the ACTIVATE and ongoing LTE studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "This", "a...
PMC9429973	Aims: To evaluate the prognostic impact of CEBPA, in particular CEBPA mutations in AML.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "evaluate", "the", "prognostic", ...
PMC9429973	The use of OGM in various research and diagnostic labs is being validated and implemented around the world.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "use", "of", "OGM", "in", ...
PMC11397654	In fact, only the calixarene derivatives 36 (Figure 10), hosting the chemotherapeutic drug methotrexate, 49a,b (Figure 16) bearing the 7-ethyl-10-hydroxycamptothecin or doxorubicin anticancer agents, and the supramolecular nanoplatform based on the pillarene 78 (Figure 25) were submitted to in vivo (mice only) assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10671321	A sequence coding for GFP was introduced following an IRES sequence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "sequence", "coding", "for", "GFP", "was", "introduced", "following", "an", "IRES...
PMC11718817	Concordant with our results on caspase-3/7 activation, performing caspase-3 activation analysis in time-lapse microscopy videos was used as an endpoint by Teijeira et al. recently .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11767725	Additionally, ROS interact with lipid peroxidation pathways, generating malondialdehyde and 4-hydroxynonenal, which further exacerbate cellular damage and impair lipid synthesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additio...
PMC11682172	The data presented in this study are available in this article (and supplementary material).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "presented", "in", "this", "study", ...
PMC11473750	While MYCN amplification is detected in 20–25% of neuroblastoma patient tumours, and 11q deletion in 35–45%, the two CNVs occur as mutually exclusive cancer driver events.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10522430	Among the fungi rich in polysaccharide content, G. applanatum stands out; however, its anticancer activity necessitates further investigation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "the", "f...
PMC11015054	METTL14 can inhibit liver cancer metastasis in an m6A‐dependent manner by increasing miR126 levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "METTL14", "can", "inhibit", "liver", "cancer", "metastasis", "in", ...
PMC11680391	The contract requires general monitoring of the herd’s health status, with particular attention given to areas with the highest consumption of antimicrobials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11577421	However, this barrier effect may depend on the specific cell and NP types, as this phenomenon has been observed in some but not all instances.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11781181	The mapped clean-read number was normalized to RPKM (reads per kilo of per million mapped reads).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mapped", "clean-read", "number", ...

PMC11727062

Consequently, this inhibition of glycolytic enzymes contributes to the suppression of cellular drug resistance development (Jalal et al. 2022).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ...

PMC5386478

For generation of multicellular spheroids, 5 × 10 cells were added into each well of polyHEMA-coated 96-well plate and placed in a 37 °C humidified incubator with 5% CO2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Summary/Conclusion: Therapy related mortality remained high and EFS and OS has a trend for improvement compared with previous published papers from the same centre.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11343332

Following that, the cells were maintained at 37° in the CO2 incubator for 4 hours.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "that", ",", "the", "cells", "w...

PMC11740907

Table 3 demonstrates that the creation of microemulsion was unsuccessful in cases where a surfactant combination was not used (F1-P5W30-BW-SLNs and F3-P5W30-BW-SLNs).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC10297204

STSs arise in proximity to the sciatic nerve .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "STSs", "arise", "in", "proximity", "to", "the", "sciatic", "nerve", "." ] } ]

PMC11745823

Furthermore, RIT1 serves as an independent prognostic marker of poor prognosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "RIT1", "serves", "as", "an", "independent", "prognostic", "m...

PMC9351137

Bars with different dashed lines indicate SRCAP complex-specific subunits (CFDP1) or p400/Tip60-specific subunits (p400 and Tip60).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bars", "with", "different", ...

PMC10470467

p < 0.01; ***p < 0.001.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.01", ";", "*", "*", "*", "p", "<", "0.001", "." ] } ]

PMC11758416

To address this, culture T cells with IL-15 or IL-7 during the pre-stimulation step.•Include a positive control of CD8 T cells with expected cytotoxic function to ensure a successful assay was performed.•Periodically stain the CD32-expressing L cells for CD32 to ensure expression is not lost.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

In all patients, the first mutational hit occurred on epigenetic remodeler genes (i.e. TET2, ASXL1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "all", "patients", ",", ...

PMC9429973

The endoscopic appearance was an ulcero-budding process in 59.5% of cases, gastric infiltration (9.5%) and a large folds or polyploid mass (7%).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11673128

At the forefront of innate immunity, targeting tumor-associated macrophages (TAMs) within the tumor microenvironment (TME) has been considered a promising immunotherapeutic strategy .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10933092

Green represents lncRNA, red represents mRNA, blue represents miRNA, and pink represents reported miRNA.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Green", "represents", "lncRNA", ",", "red", ...

PMC11697189

Kaplan-Meier curves of overall survival (OS) for ccRCC in three clusters. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kaplan-Meier", "curves", "of", "overall", "survival", "(", "OS", ...

PMC11609529

ES-2 cells were seeded at 500 cells per well in 12-well plates and treated with CA3 or VPF at the indicated concentrations (n = 3, mean ± SD).

[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11592837

To compare the time series of cfDNA formation between PBMCs and Jurkat cells, fragments of nuclear (Alu 115 bp and Alu 247 bp) and mitochondrial marker (MTCO3 67 bp and MTCO3 296 bp) were quantified.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6450504

After filtration, PEIPOS were characterized by size, polydispersity index (PdI) and zeta potential (ZP) by dynamic light scattering (DLS) in a Zetasizer Nano ZS 90 (Malvern Instruments, UK), with the samples previously diluted with ultrapure water.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11448304

Radioresistance contributes to metastasis and recurrence in non-small cell lung cancer (NSCLC) patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Radioresistance", "contributes", "to", "metastasis", "and", "recu...

PMC9429973

However, significant reduction in HsCRP, procalcitonin and ferritin pre and post CPT was found.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "significant", "reduction", "in", "HsCR...

PMC11585994

Agarose gel electrophoresis determining the optimal G5 to nucleic acid (N:P) ratio in the nanoparticles.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Agarose", "gel", "electrophoresis", "determi...

PMC11718109

Scale bar, 10 μm; inset: 2.5 μm.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "10", "μm", ";", "inset", ":", "2.5", "μm", "." ] } ]

PMC8316344

C TRIB2 knockout prolonged while TRIB2 overexpression shortened the half-life of TFRC protein.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "TRIB2", "knockout", "prolonged", "while", "TRIB2", "overexpression", "...

PMC10142392

In addition, one approach to accessing ABC-type multi-arm structures involves using a low molecular weight initiator that has a free hydroxyl group, along with an ATRP initiator branch (such as bromobutyrate) and an NMP initiator branch (such as TEMPO alkoxamine).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11173119

Familial Mediterranean fever (FMF) is a systemic autoinflammatory disorder caused by inherited mutations in the MEFV (Mediterranean FeVer) gene, located on chromosome 16 (16p13.3) and encoding the pyrin protein.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9370419

Third, the cells were lysed using the HiBiT Lytic Detection System after 12 h. Ten minutes after the lysis, the level of HBx was measured by the level of luminescence (Figure 1B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8348645

Then, the protein expression of BAX and BCl2 was studied using fluorescent dye to determine the regulation of the BAX and BCl2 genes.

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PMC7840816

The data indicate that upregulation of SOX9 favors PTC progression and metastasis.

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PMC9429973

No thrombotic or cardiovascular complications occurred during follow-up.

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PMC9219615

To distinguish between apoptotic and necrotic cell death, we performed an Annexin V-FITC/PI assay.

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PMC9429973

To identify BCL-2+ tumor cells an immunohistochemical staining method was used.

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PMC9429973

Summary/Conclusion: T22-PE24-H6 selectively kills AML cell lines and BM samples from AML patients with CXCR4 overexpression.

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PMC11345828

However, the 2-carboxy-1H-indol-7-yl motif allows for functionalization of the indole 4- and 5-positions, which were further examined.

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PMC10237474

Expi293F cells were seeded to a total number of 75x10 in 30 mL of Expi293™ Expression Medium and grown to 3x10 cells/mL density with a viability >95%.

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PMC11301242

European Nucleotide Archive and Sequence Read Archive were queried for WGS or CIRCLE-seq data on hematologic malignancies.

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PMC11116779

Collectively, this investigation underscores the importance of concentration (dose-dependent effect) and exposure duration as pivotal factors in assessing the toxic effects of PS-NPs on alveolar epithelial cells.

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PMC11321678

Previous reports showed SHH MB cells can transdifferentiate into IL‐4‐secreting astrocytes, which induce microglia to release IGF1 and IL‐10, both crucial for tumor progression.

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PMC11593084

The tumor volume was measured on the indicated days.

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PMC11779876

Mechanisms of primary resistance might be at work which warrant further investigation.

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PMC9429973

Wells with individual clones had been analyzed further.

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PMC9429973

However, pts unable to undergo HDCT/HSCT have limited treatment options and often have poor outcomes.

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PMC11599565

In addition, the neuronal morphology was rapidly established when commercially available and primary ovarian carcinoma cells were cultured in the form of organoids.

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PMC10443665

For the resistant cell line (CCRF-CEM/R) same procedure was repeated.

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PMC9429973

Results: Enrollment in this study has begun in Europe.

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PMC5839394

The AgNPs-EPS is more active than AgNPs-EPS, with SKBR3 and 8701-BC cell lines being more sensitive to AgNPs-EPS treatment in comparison to HT-29, HCT 116 and Caco-2 colon cancer cell lines.

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PMC11743316

The anti-apoptotic protein BIRC3 serves as one of several inhibitors of apoptosis proteins that are necessary for preserving cell survival, and prior research has demonstrated that CRL4 mediates OC chemoresistance by targeting this protein .

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PMC11672881

For Annexin V staining, cells were grown in 60 mm plates until reaching 90% confluence, treated with 25 µM curcumin, 10 µM thymoquinone (TQ), or their combination, then trypsinized and counted.

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PMC9429973

Molecular diagnosis of β-thalassemia was performed by automatic Sanger sequencing.

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PMC11574271

Identification of MMP12 prompted us to study whether RON-mediated bladder cancer cell invasive growth is channeled through this functional protein.

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PMC6163708

We can speculate that higher doses of GANT61 or a prolonged time of treatment would have a better effect in eradicating tumor cells.

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PMC8633974

The HIV-1 proviral genomes isolated from elite controllers display large deletions of env sequences flanked by tat/rev amongst other regulatory genes .

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PMC11218145

injection.

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PMC11422150

Suppressing activated macrophages/microglia may improve tissue damage and facilitate functional recovery in SCI (Tian et al., 2007; Popovich et al., 1999).

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PMC9325715

The complex also was characterized by numerous techniques: spectrometric (ICP-MS), spectroscopic (UV–Vis, ATR-FTIR), electron microscopy (TEM–EDX), SDS-PAGE.

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PMC11540664

Thus, our results suggest that peripheral blood lymphocyte count can be used as a biomarker to identify patients with liver cancer who will benefit from TKI+PD-1 combination therapy.

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PMC11715644

Whereas researchers have previously studied collective cell migration in defined confinement, how cells collectively negotiate and move from unconfined to confined matrices remains unclear.

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PMC10965315

These findings suggest that harmaline may have the potential to be a therapeutic drug for ovarian cancer by triggering apoptosis and suppressing invasion and migration.

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PMC11714165

Comparing the DN‐F group with the control groups, it was evident that bone parameters, such as bone volume, bone surface area, trabecular number (Tb.

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PMC10589262

By targeting mutant KIT expression itself, HSP90 inhibitors offer a promising approach for GIST treatment that may overcome imatinib resistance mechanisms associated with secondary mutations.

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PMC11541409

In a phase IB/II study (NCT04138381) involving imatinib-resistant GIST patients, the toxicity of selinexor was manageable, clinical benefit rate (CR + PR + SD) ≥ 16 weeks was 42% (95% CI: 0.181–0.685) in cohort A (n = 12, imatinib 400 mg/day, weekly selinexor) and 28% (95% CI: 0.213–0.354) in cohort B (n = 18, selinexor 60 mg twice weekly) .

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PMC10747160

For the Griffithsin pre-incubated with 3t3 cells protocol, 50 μL stock dilution of each requisite Griffithsin variant (WT-Grft, Q-Grft, GLG-3A) was prepared in PBS.

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PMC11530949

Additionally, the FTIR picture of the Ag-doped CuO NPs shows strong, distinct peaks in the range of 1123.26, 1452.30, and 2832.19 cm-1 that are associated with C-H plane bending vibration, CH3 symmetric bending, CH2 stretch vibrations, and OH stretch.

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PMC11683240

These severe pathologies are PT-mediated, and risk factors associated with death (39, 40, 41, 42).

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PMC10926885

The material transported by microtubules is very rich; mRNA, organelles and vesicles are just a few of the intracellular molecules that dynein transports.

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PMC11488203

Transfection of three different MSC populations with miR-454 and subsequent quantification of SDF-1 production by a corresponding ELISA, however, demonstrated little if any effects on the SDF-1 production of either MSC population (suppl.

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PMC11763111

As ready-to-use therapeutic products, they offer promising treatment options for various hematological malignancies.

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PMC10547921

Compared to tubulin inhibitors, DNA inhibitors can act on the whole cell cycle by destroying DNA through double-strand breakage, alkylation, chimerism, crosslinking, etc.,

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PMC2614415

The sub G0/G1 population represents apoptotic cells.

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PMC11472639

Myeloma patients in remission (MREM) were also recruited to preliminarily explore how a single bout of exercise affected immune cell frequency, including clonal plasma cells, in blood of patients in remission.

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PMC9559528

Additionally, this patient should have also been tested for concurrent Gonorrhea and Chlamydia sexually transmitted infections.

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PMC9318744

GAPDH was used as an endogenous control gene (sense 5′-TCCTCCACCTTTGACGCT-3′ and antisense 5′-TCTTCCTCTTGTGCTCTTGC-3′).

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PMC10253973

One experiment used transgenic mouse cells that contained human colonic adenocarcinoma cells (LS174T).

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PMC11089031

In ccRCC, the expression of ZNF692 was significantly higher in tumor tissue than in adjacent normal tissue, and the expression of this gene was associated with more advanced cancer stage and poor prognosis.

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PMC7887261

b Increased DNA damage (γH2AX) levels in five out of the six genes knockdowns (mean ± SEM, n = 2~4), MLNR, CHEK2, POMC, ATM, and MME, compared with non-targeting (NT) siRNA control.

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PMC10213199

Larvae group, KEGG pathway enrichment analysis was conducted and showed that various metabolic pathways were downregulated (Fig. 2, Fig. 3).

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PMC11731161

Statistical analysis was performed using Prism 8.0 (GraphPad Software, La Jolla, CA).

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PMC9919300

More people are expected to be affected in the coming years , and NAFLD represents a problem of both global health and the economy .

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PMC10329237

Cell viability assay Cell viability was examined by the MTT assay.

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PMC11471157

Organization of cell spheroids by HaCaT cells and NIH/3T3 cells on Day 3.

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PMC11789597

Tests were performed using GraphPad Prism software (Version 9, GraphPad Software, La Jolla, CA, USA).

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PMC11257988

Once activated, RAS interacts with multiple effector transcription factors and activates the mammalian target of rapamycin (mTOR).

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PMC11733919

However, limited components of the senescent surfaceome were comprehensively and functionally characterized and validated as universal cell surface markers in numerous senescent cell types.

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PMC11739504

EV indicates empty vector (pCMV-tag2B) and FL-Kat2b indicates full length Kat2b-pCMV-tag2B. (

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PMC8777939

For the invasion assay, all steps were the same as those described above, but the incubation time was 36 h. For the scratch wound-healing assay, A2780 and A2780-ADR cells (5 × 10 cells/well) were seeded into six-well plates and scratched with a 1 mm scratch tip (SPL Life Sciences, Pocheon, South Korea) when the cells reached 90% confluence.

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PMC9985266

Autophagy is an intracellular degradation pathway that is essential for cell homeostasis and is evolutionarily conserved .

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PMC11411131

The N-terminal signal peptide regions were deleted from the expression constructs.

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PMC9429973

Aims: This analysis focuses on normalization of Hb levels in pts treated in the ACTIVATE and ongoing LTE studies.

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PMC9429973

Aims: To evaluate the prognostic impact of CEBPA, in particular CEBPA mutations in AML.

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PMC9429973

The use of OGM in various research and diagnostic labs is being validated and implemented around the world.

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PMC11397654

In fact, only the calixarene derivatives 36 (Figure 10), hosting the chemotherapeutic drug methotrexate, 49a,b (Figure 16) bearing the 7-ethyl-10-hydroxycamptothecin or doxorubicin anticancer agents, and the supramolecular nanoplatform based on the pillarene 78 (Figure 25) were submitted to in vivo (mice only) assays.

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PMC10671321

A sequence coding for GFP was introduced following an IRES sequence.

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PMC11718817

Concordant with our results on caspase-3/7 activation, performing caspase-3 activation analysis in time-lapse microscopy videos was used as an endpoint by Teijeira et al. recently .

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PMC11767725

Additionally, ROS interact with lipid peroxidation pathways, generating malondialdehyde and 4-hydroxynonenal, which further exacerbate cellular damage and impair lipid synthesis.

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PMC11682172

The data presented in this study are available in this article (and supplementary material).

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PMC11473750

While MYCN amplification is detected in 20–25% of neuroblastoma patient tumours, and 11q deletion in 35–45%, the two CNVs occur as mutually exclusive cancer driver events.

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PMC10522430

Among the fungi rich in polysaccharide content, G. applanatum stands out; however, its anticancer activity necessitates further investigation.

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PMC11015054

METTL14 can inhibit liver cancer metastasis in an m6A‐dependent manner by increasing miR126 levels.

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PMC11680391

The contract requires general monitoring of the herd’s health status, with particular attention given to areas with the highest consumption of antimicrobials.

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PMC11577421

However, this barrier effect may depend on the specific cell and NP types, as this phenomenon has been observed in some but not all instances.

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PMC11781181

The mapped clean-read number was normalized to RPKM (reads per kilo of per million mapped reads).

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