Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC6461034
Divide a volume of cell suspension expected to yield 10–12 mg protein over 50‐ml tubes.
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PMC11653168
These data suggested that the effect of Stattic on p-STAT3 is influenced by the initial expression level of p-STAT3 in the T-ALL cell line being studied.
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PMC9874064
The dosage of cisplatin, NP-Pt, and NP-Pt-USP1i was set at 3.5 ​mg ​Pt/kg.
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PMC11746948
Quantification of GPX4 protein levels (q).
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PMC11727000
FANCI, like FANCD2, is monoubiquitinated by the core Fanconi complex—an event that is essential for DNA repair through this pathway .
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PMC10154881
At 2 or 3 days after virus infection (dpi), the EGFP signal was observed under a fluorescence microscope (BZ‐X700; Keyence).
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PMC11519077
Using the transcription kit (Yekta Tajhiz, Iran), reverse transcription was utilized to create the first-strand cDNA.
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PMC9693627
Signals were recorded on Storage Phosphor screens using a STORM 865 scanner (GE Healthcare, Marlborough, MA, USA).
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PMC11283030
Since up-regulated ACLY was associated with poor prognosis of ccRCC, we hypothesize the potential oncogenic role of ACLY in ccRCC.
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PMC11727000
As BRCA2 expression varies through the cell cycle, we hypothesized that high BRCA2 may be identify tumors with a higher proliferation rate.
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PMC10890055
Cells were passaged regularly when sub-confluent using a trypsin-EDTA solution without phenol red (Gibco, 15400054, Thermo Fisher Scientific, Waltham, MA, USA).
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PMC11740207
VSELSCs also demonstrate enhanced activity in pathways promoting cellular quiescence and stress resistance, including FoxO and TGF-β, which are characteristics shared with LT-HSCs (Wojakowski et al., 2008; Ratajczak et al., 2012).
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PMC8140214
For determination of GR activity, 60 μM buffer, 5 mM EDTA (pH 8.0), 0.033 M GS-SG, 2 mM NADPH, and a sample of HepG2 cell lysate ata final volume of 1000 μl, were used.
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PMC11015054
We added puromycin at a concentration of 2 μg/mL to the cell lines after they expressed GFP fluorescence and then screened them for 48–72 h. Stable METTL5 knockdown and blank control cell lines were obtained for subsequent experiments, which were subsequently verified by western blot and qRT‐PCR.
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PMC11087055
In this study, our live-imaging system combined with the quantitative analyses, molecular tools for manipulating PS formation, and the gene expression analyses allowed us to clarify the relationships among PS morphogenesis, the polonaise movements, mitosis, and the Wnt/PCP pathway (Figure 1, Figure 2, and Figure 5A and C).
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PMC11240052
a,b) CCK-8 assay was performed to analyze the proliferation of SKOV3 and A2780 cells under different transfections. (
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PMC8358006
To determine the molecular basis of GSDs mediated gene activity, we performed integrated analyses of ChIP-seq and whole-genome bisulfite sequencing (WGBS) data in NE2 and KYSE450 cells.
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PMC11629461
Basal calcium was stable also without light irradiation in miniSOG‐NOX5‐CHO‐K1 cells (Figure 4D).
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PMC11216402
Inferred TF motif activities are supported by differential expression of stomach TFs and fibroblast genes in Mes-like GC, normal ENCODE-fibroblast, and ENCODE-stomach (**) FDR < 0.01, (*) FDR < 0.05, likelihood ratio test.
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PMC11777207
We next asked whether, in a model of psoriasis where excessive inflammation is detrimental to disease outcomes, whether we could prohibit DC migration and dampen inflammatory responses.
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PMC3274243
Human rheumatoid synovial fibroblasts (RSF) and 8701-BC breast carcinoma cells were cultured in Dulbecco’s modified eagles medium (DMEM) supplemented with 10% foetal bovine serum (FBS) and antibiotic/antimycotic, as previously described .
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PMC10940855
D, Left, representative flow cytometric analysis of Annexin V and 7AAD staining of multiple myeloma cells transduced with dEFNB2 or GFP control; right, mean levels of total Annexin V/7AAD cells and Annexin V/7AAD cells within each treatment group.
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PMC8494202
Therefore, our analysis does not include all clinical treatment details and individualized efficacy.
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PMC11638288
It was also found that in the mouse fibrosarcoma model, NK cells secrete IFN-γ in an NKp46/NCR1-dependent manner.
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PMC11401350
In addition, we have shown that that TCR stimulation in our in vitro experiment induced already severe cell death in the CD4 + PD1 malignant T cells.
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PMC11457557
It is worth noting that mutations in the Solute Carrier Family 5 Member 2 (SLC5A2) gene that encodes SGLT2, the major glucose co-transporter in the kidney's proximal tubule, known to cause familial renal glycosuria .
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PMC9429973
The probability of MRD negativity at month 12 was 88.7% (95% CI 65.9%, 96.6%).
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PMC10656496
Although loss of glucose or glutamine in the media reduced the growth of 143B and drastically reduced growth when both were removed (Fig. 1A), in the 90/10 coculture, 143B is still able to outcompete SAOS2.
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PMC9429973
Although intriguing, it remains to elaborate whether the haploinsufficiency of BTK in males skew in the degree of ibrutinib resistance.
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PMC11640419
It appears that sustained JNK activation is associated with apoptosis, whereas acute and transient JNK activation is involved in the proliferative or cell survival pathway .
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PMC7305184
Pulsed electric field treatment has increased over the last few decades with successful translation from in vitro studies into different medical treatments like electrochemotherapy, irreversible electroporation for tumor and cardiac tissue ablation and gene electrotransfer for gene therapy and DNA vaccination.
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PMC11448304
a Frequency of the amino acid residues around the Khib sites.
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PMC11665555
Therefore, cell surface stem markers CD44 and CD36 were evaluated in cells exposed to 10 nM gemcitabine for 72 hours using FACS.
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PMC11699465
Cut&Tag assay was performed as described (37052060).
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PMC9429973
The AI algorithm was trained only with cells in which all 3 experts agreed on the class (n=28,058).
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PMC3164356
We investigate the CHO-K1 genome and transcriptome for insights into protein glycosylation and viral susceptibility because these processes affect the yield and quality of therapeutic protein production.
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PMC11766174
However, the average number of CA-positive cells observed in the dilutions containing 100 or fewer CA-positive cells per million was inconsistent with the expected frequencies.
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PMC11777207
Other samples were selected from a biorepository of patients who had undergone liver transplantation and collected under the IRB protocol 06-0566 and protocol 23-2301 (table S1).
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PMC7185206
Corresponding cancer subtype names and data are listed in Table 1. ***
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PMC11411004
Lysine-specific demethylase 1 (LSD1) functions as a flavin adenine dinucleotide (FAD)-reliant enzyme, tasked with eliminating both single and double methylation occurrences on histone H3 lysine 4 (H3K4) and histone H3 lysine 9 (H3K9) (Egolf and Capell 2020), with a tight regulatory relationship with HDAC, leading to their synergistic action (Anastas et al. 2019).
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PMC11665555
The subsequent KO of OXCT1 of the 5637GR cells using CRISPR/Cas9 (GR-OXCT1KO) resulted in a dramatic restoration of gemcitabine sensitivity, near to that of the 5637P line (5637P; IC50 = 0.001 μM; Figure 2G).
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PMC11190538
Fig. 6 A, B show the pH and acidity variations in the yoghurt samples during 21 days of storage.
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PMC10820104
Based on the remarkable cytotoxicity results from the bioactivity-guided screening of the starting fraction 4, the purified compounds 1 and 4 were characterized in full dose–response curves in the selected pancreatic cancer cell line.
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PMC4816271
Increasing clinical experience has demonstrated that CARs incorporating binding domains derived from murine antibodies can elicit severe reactions in patients, which can contribute to enhanced clearance of transduced T cells and CAR activation with considerable toxicity .
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PMC11519567
We show that the physical properties of oncogenic fusion protein SS18-SSX condensates within cells undergo alterations compared to the proto-oncogene protein SS18.
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PMC11787381
A micro pipette was used to administrate the corresponding volume on the treated nostril.
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PMC11787651
To demonstrate the speed and reliability of the ZenoTOF method, a single sample of histones extracted from untreated HeLa cells was injected and analyzed 100 times in 2 days.
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PMC11593084
The culture supernatants of hybridomas were screened using ELISA with PDPNec.
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PMC9429973
Perhaps even more strikingly, ex vivo culture of APL and other favorable AML subtypes such as inv (16) or NPM1 mutant leukemic cells on M2-macrophages for 48h was sufficient to “train” these cells to engraft and induce fatal leukemia.
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PMC9436459
Comparion with kuwanons J and R (81 and 86) , artonins C and X (84 and 85) from A. heterophyllus have a 3-methylbut-1-en-1-yl unit at C-11" instead of a prenyl group.
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PMC10988555
Evaluation of the autophagy induction in A2780 cell line after 48 h of exposure to the IC50 of the complexes 2–4 by flow cytometry using the Autophagy assay.
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PMC8978939
ns, not significant; *p = 0.0306, **p = 0.0005, two-tailed chi-square test. (
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PMC9429973
In addition, PREDIGA project included an epidemiological, clinical, observational, non-interventional, multicenter, retrospective and prospective, cross-sectional with a single cohort study.
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PMC3019555
HIF-1α MBs incubated at 37°C for 1 h with a complementary (C) or sense (S) DNA ODN or total RNA from MCF7 cells.
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PMC11411131
The sensitivity of Krab-Sec/Luc to MeHg was measured to validate the sensor vectors.
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PMC9444294
Cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100.
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PMC10197932
Similar results were obtained with another myeloid cell line OCI-AML-3.
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PMC11803149
Aging decreases naïve T cell abundance, while increasing numbers of dysfunctional T cell subsets, such as virtual memory T cells and senescent-like T cells (2).
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PMC9429973
To test UCART20x22 activity, we use a combination of in vitro cytotoxicity assays against tumor cell lines, along with pre-clinical in vivo models assessing efficient dose/response and recapitulating antigen escape.
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PMC5963610
The fluorescent systems used to EGFR, pEGFR, pStat3, NGcGM3, uPAR, α5β1 integrin, Src, pSrc, FAk and pFAK was the same to FACS assay.
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PMC10850553
The anti-Thy-1.1-induced glomerulonephritis model in rats was created following the previous study.
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PMC8658661
However, the article by Jennen et al. noticed that HepaRG is more suited in an in vitro liver model for biological interpretations of the effects of exposure to chemicals, whereas HepG2—for classification studies using the toxicogenomics approach .
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PMC9429973
Aims: To compare the effects of horizontal (co-housing-mediated) versus vertical transmission of wild microbiota and pathogens into C57BL/6 mice with a focus on generation of mature cells from HSPCs.
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PMC11502443
The GIP receptor was initially reported to display equivalent binding of GIP(1-42) and GIP(1-30)NH2 in transfected Chinese hamster lymphoblast cells, and was characterized as Gαs-coupled, based on cAMP accumulation in the absence of Ca influx (Volz et al., 1995).
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PMC9429973
Adverse cytogenetics was associated with treatment failure only in the R/R group (Relative Risk=0.10, p=0.005).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Adverse", "cytogenetics", "was", "associated...
PMC9250505
injection using immunohistochemistry (IHC) as described in the methods.
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PMC11588085
Some lncRNAs have been proposed as promising cancer biomarkers and therapeutic targets due to their documented molecular functions and high level of expression specificity (18, 19).
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PMC11371627
Five samples of fresh EDTA and two samples of RBCs were detected with antibodies (a) anti-k and (b) anti-K. Our patient is marked in red. (
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PMC9429973
Pts (560 planned) will be randomly assigned (1:1) to receive 28-day cycles of tec-dara or investigator’s choice of DPd or DVd (stratified by investigator’s choice of DPd or DVd, ISS stage, and number of lines of prior tx).
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PMC9429973
When AA_DX patients were stratified into those who progressed (n=6) vs those who did not (n=9), or when AA_DX vs AA_PROG was compared in patients with matched samples (n=6) there were no significantly differentially expressed proteins identified.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4360730
These databases describe biological samples used in experimental assays recorded in various linked databases.
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PMC11656657
Moreover, approaches aimed at neutralizing G-CSF, a key chemokine that not only modulates MDSCs but also enhances Treg activity , or directly reducing MDSCs along with other relevant immunosuppressive elements of the TME, such as Tregs and TAMs, could significantly enhance the response to GD2.CAR T-cells.
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PMC9429973
Summary/Conclusion: Our findings indicated the possible mechanisms anti-PD-1 agents may contribute to the treatment of MDS.
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PMC11541241
They addressed a feed‐forward adenylate cyclase MAC1‐cAMP‐TOR‐adenylate cyclase subnetwork that could reinforce cAMP/PKA‐dependent appressorium formation in response to favourable environmental conditions (Sun et al., 2019).
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PMC11127909
Experiments were performed three times (N = 3).
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PMC6835428
Moreover, 0.5%PEIPOS/siMDR1 was not tested, so it is not possible to evaluate the effects of the siRNA per se.
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PMC6803987
Then, 10 μL of the mixture was taken for cell counting.
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PMC9429973
70% of the data for training and 30% for testing were randomly separated.
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PMC9386809
Unfortunately, using a similar protocol with ZrCl4, we could not obtain the anticipated Cl2Zr–BPC complex 2.
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PMC6442998
GIST882 and GIST48 cells were seeded in 96-well plates (TPP Techno Plastic Products AG, Trasadingen, Switzerland) at a concentration of 10,000 cells/well supplemented with 100μl of medium 48h before drug treatments.
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PMC11701801
−CP-C27 (n = 8 biologically independent mice per group); +CP-C27 (n = 8 biologically independent mice per group).
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PMC10956161
At present, despite the achievements in the research of the pathogenesis of lung adenocarcinoma and the development of new treatment methods, lung adenocarcinoma is still one of the most aggressive and deadly cancer types with a total survival period of <5 years.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9611901
A high level of primary DNA damage measured after 24 h does not only mean a high genotoxic risk.
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PMC9841531
After being cooled in an ice–salt bath, N,N-dimethylformamide was subjected to phosphoryl chloride (POCl3; 2 equiv).
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PMC8193813
It has an NO2 detection range of 0–10 ppm with a resolution of 0.1 rms noise (parts per million equivalent) and linearity error of 0 to 0.6 ppm at full scale.
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PMC11575040
Cell cycle analysis was conducted using a Coulter EPICS XL flow cytometer.
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PMC9429973
These findings highlight the importance of monitoring using PROMS in clinical practice and extra attention and support for the negative consequences of the hospital admission for VOCs, affecting the HRQoL. S. Al Jaouni Hematology Department, Faculty of Medicine,King Abdulaziz University, Jeddah, King Saudi Arabia; Hematology Department, King Abdulaziz University, Jeddah, Saudi Arabia Background: The potential for precision medicine a wellness vision and improve the quality of life of thalassemia.
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PMC11734514
Ergosteroids are predicted to induce a cytotoxic effect by triggering apoptotic programmed death in A549 cells.4 Chemical structure of (A) Ergost-22-en-3-one and (B) Ergost-7-en-3-ol.
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PMC9503685
The membrane composition of cancer cells differs from primary (non-transformed) cells.
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PMC11633763
Furthermore, we examined the effect of USP22 on osteosarcoma cell apoptosis using flow cytometry and found that USP22 knockdown significantly increased 143B cell apoptosis compared with that in the shNC treatment group (Figure 2I).
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PMC11656657
As reported in Fig. 4K and Supplemental Fig. 11A, we obtained a robust engraftment of the tumor at day + 128 (compatible with a high tumor burden model, having a bioluminescence close to the saturating value of 1E10 p/s/cm/sr).
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PMC10878518
C,E) Cell viability was analyzed using the WST-1 assay in bone and soft-tissue sarcoma cells (C) and normal fibroblasts (E) at 24, 48, and 72 h after infection with OBP-401 at the indicated doses.
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PMC9429973
To assess the difference in survival between the two groups, we used the Log-rank test on Kaplan-Meier survival curves.
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PMC11640555
Traditional therapeutic approaches, such as surgery, chemotherapy, and radiotherapy, do not produce satisfactory life extension since less than 5% of patients diagnosed with GBM survive for more than 5 years .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9019892
Briefly, the KIT wt and mutant genes were cloned into the pMSCVpuro retroviral vector for virus production in combination with two helper plasmids in HEK‐293T cells.
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PMC11803918
The size of hybrid exosomes was 171.76 ± 2.84 nm, and the polydispersity index (PDI) value was 0.23 ± 0.03, implying a suitable size distribution after membrane fusion (Figure 2H).
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PMC3203927
Cells cultured in three dimensional (3D) scaffolds as opposed to traditional two-dimensional (2D) substrates have been considered more physiologically relevant based on their superior ability to emulate the in vivo environment.
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PMC11694066
E, The GR_13-PDX-O model was established from the primary peritoneal tumor of a patient with DSRCT, with confirmation of EWSR1::WT1 fusion by FISH and WT1-Cter IHC (Supplementary Fig. S8).
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PMC11763126
Rudzinska-Radecka et al. found that Cathepsin B is highly expressed in renal cancer and promotes ccRCC progression .
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PMC11224020
Nonetheless, our results emphasize that the physical properties of tissues indeed contribute to shaping immunity.
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