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PMC11650848
The Elekta Neuromag 306-channel MEG system was used to record MEG responses.
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PMC11345828
Low-resolution mass spectra were obtained on an Agilent 1200 series 6140 mass spectrometer with electrospray ionization.
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PMC10587429
Trypsin-EDTA (0.25%) (25-200-114, Fisher Scientific, Waltham, MA). -
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PMC11767817
Additionally, given that 2a-B reduced Akt phosphorylation, we were also interested in whether this reduction could potentiate its activity.
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PMC11380454
The cells were collected and stained with 5 µl of propidium iodide (PI).
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PMC11047729
It presents various anti-cancer effects, such as growth inhibition, apoptosis activation, and the differentiation of several kinds of malignant cells .
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PMC9429973
None of the socio-economic variables was associated with higher TRM in the MVA adjusted.
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PMC9429973
J Clin Oncol.
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PMC9429973
Image: Summary/Conclusion: In this large study, robust biological and clinical predictive factors of CRS and ICANS were identified.
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PMC11610461
Successive slides of the same renal carcinoma tissue were stained and observed in the same field of view.
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PMC11740508
A–E Values indicate mean ± SEM.
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PMC10443665
Although the high dose of MTX can significantly increase cure rates and improve patients' prognosis (30), increased MTX plasma concentration leads to numerous adverse effects (10).
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PMC8481254
A The chemical structure of CA.
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PMC8592717
It significantly controlled the serum levels of MDA and TNF-α, and renal MDA level; while on the other hand, it upregulated the serum and renal total antioxidant status (TAS) and SOD levels, and histopathological scores .
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PMC10955424
Cell lysate samples were prepared for loading by adding lysis buffer (#9803 Cell Signaling Technology, MA, USA) containing protease inhibitors (P8340 and P5726, Sigma, Germany) and phosphatase inhibitor (P-1517, AG Scientific, CA, USA) to the cell pellets.
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PMC11679033
This observation underscores the selective nature of cannabinoid-induced cytotoxicity, which can vary based on cell type, exposure duration, and concentration, as cannabinoids may selectively trigger intracellular death mechanisms while maintaining overall cell membrane stability .
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PMC11750712
One patient (dosed at 25 × 10) developed grade 2 EBV reactivation on study day 27 in the context of immune-mediated thrombocytopenia.
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PMC9878562
The finding suggested that VAL-ko and VAL-wt might perform a secondary migration, which could be triggered either by microgradients of CXCL12 created by ACKR3 VAL-wt or by another stimulus that is released during the migration of VAL-wt along a CXCL12 gradient.
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PMC10850553
Scale bar: 50 μm.
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PMC11787355
To evaluate protein abundance, we analyzed n = 20 matched primary and recurrent glioblastoma samples and found patient-individual PTPRZ1 levels without temporal alterations between primary and recurrent tumors (Fig. 1e, f).
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PMC11802855
The results demonstrated that both p-STAT3 expression and cell proliferative capacity were significantly suppressed (Fig. 7G–J).
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PMC8345486
All hydrogen atoms were localized on a difference Fourier map.
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PMC10823017
In addition, atypical PKCs (PKC-ί and PKC ζ) are overexpressed in most cancer cells, and they play a central role in tumor progression and the metastasis of different types of cancers.
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PMC10631132
A total of 10 µM of Rho-associated, coiled-coil containing protein kinase (ROCK) inhibitor Y-276432 was used when defrosting to improve cell survival.
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PMC11365427
RT-qPCR shows mRNA expression of ERS related genes ATF3, DDIT3, and apoptosis related gene TNFRSF10B in NCI-H929 and RPMI-8226 cells after 48 h of phenylalanine deprivation. (
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PMC11106977
However, our current understanding of this topic is limited, and further research is needed to better understand the role of O-GlcNAcylation in regulating chondrogenic differentiation and development.
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PMC9429973
iMCD and non-iMCD cohorts were matched (1:50) by age group (0-17, 18-44, 45-54, 55-64, >65 years), sex, insurance type, history in database, and region.
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PMC9429973
In 08.2019, a Global Expanded Access Program (EAP) was implemented to provide access to patients (pts) prior to regulatory authorization of TAG in real-world practice.
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PMC11683240
Third and fourth, PT was preincubated on cells for 15 min at 37 °C and was either present in the medium while α1AT or solvent control were added or washed away before adding α1AT or water.
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PMC9429973
Frail pts experienced more G3 TEAEs and treatment discontinuations with PVd vs Vd, but treatment duration was longer with PVd vs Vd.
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PMC11525028
∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001, by two-way ANOVA with Dunnett’s multiple comparisons test (C) and one-way ANOVA with Dunnett’s multiple comparisons test (D, E, F, K, and L).
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PMC11319300
When the fragment baits containing the promoters of CCND1 (pink arrow in Figure 2B) and LTO1 (blue arrow in Figure 2B) were taken as the viewpoints, interactions with the MYEOV-3′-putative enhancer were observed.
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PMC6901583
Overall, our findings indicated that BRD4 is likely to be involved in angiogenesis in GIST.
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PMC6461034
Tumor biopsies were taken both before and after 2 weeks of erlotinib treatment.
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PMC5035325
Breast ductal carcinoma is positive tissue for human EGFR and NeuGcGM3.
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PMC10820104
For cell cycle analyses, the cells were suspended in 100 µL of hypotonic buffer (1% sodium citrate, 0.1% Triton X-100, and 50 µg/mL propidium iodide in double-distilled water).
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PMC11286266
Assuming the endoplasmic reticulum (ER) constitutes 10% of cell total volume (Alberts et al., 2002), the concentration of CRT in the ER of CHO-K1 cells was estimated to be around 7 µM. To examine a possible interaction between CRT and ATF6α in cells, HEK293T cells were transfected with either GFP-ATF6α_LD or GFP-ATF6α_LD, followed by selective recovery using GFP-Trap Agarose and subsequent immunoblotting with an anti-CRT antibody.
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PMC11127909
Experiments were performed three times (N = 3).
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PMC11703896
The current study aimed to demonstrate the potential variability of rapamycin treatment effects among different cancer receptors (Fig. 3).
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PMC11742231
Several computational models have been developed to predict miRNA-disease associations by integrating heterogeneous biological data and employing advanced machine-learning techniques.
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PMC6461034
Add 1 ml cold IP buffer per 10 mg protein input to the bead pellet and mix by inverting five times.
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PMC11718817
Since then, migration pattern analysis has been clearly linked to effector function of CTLs .
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PMC9429973
Therefore, we will investigate how the microbiota at diagnosis differs in patients who achieve MRD negativity and those who still are MRD positive after treatment.
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PMC11723947
crRNA guides targeting Cbx3 (GCTTGAGCTGTAGGCGCGGA, GACCCGGAGCAGCTCGGAGG and GGCCTCCAACAAAACTACA) were provided by IDT.
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PMC11789597
All these findings indicate that targeting CAV1 in MM cells boosts NK cell‐mediated cytotoxicity and antibody‐dependent cellular cytotoxicity.
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PMC11612794
CENP-T is shown as a cartoon. (
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PMC11489351
For C and E, significance was determined using Kruskal–Wallis with Dunn’s multiple comparisons correction: ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001.
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PMC11741906
The miRNA expression profiles of a cisplatin-sensitive A2780 cell line and two cisplatin-resistant cell lines, A2780cis and SK-OV-3, were analyzed using PCR array and qPCR.
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PMC4270159
SDS-PAGE separation: a. Prepare the lysate sample by adding SDS reducing loading dye to ∼25–30 µg of protein sample and boiling at 95°C–100°C for 5 min.
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PMC11705547
Interestingly, the type of TIME can influence the response to cisplatin .
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PMC11547917
Four out of the five assays were chosen to compare our extract with the literature data: 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), total antioxidant capacity (TAC), total flavonoids content (TFC) and total polyphenolic content (TPC).
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PMC9429973
Treatment by free dendritic molecules led to increasing of expression of PD-L1, TIM-3 and CD47 on Jurkat cells, but decreased the IL-10 secretion.
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PMC10142392
In the study by W. Zhang et al. , another multi-arm structure was described in detail and named toothbrush-type amphiphilic copolymer.
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PMC11544771
Lung cancer, including small cell lung cancer and non-small cell lung cancer (NSCLC), is the leading cause of cancer-related deaths worldwide .
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PMC11698348
Our data suggest that Elf5 expression found in the epidermis and HFs indicates the importance of Elf5 to balance and regulate proliferative potential of stem/progenitors, the transition of keratinocytes from proliferation to early differentiation and to also regulate the suprabasal expression of basal genes, thereby potentially acting as a switch between proliferation and differentiation of keratinocytes, a role similarly undertaken by Elf5 in mammary gland development .
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PMC10376064
Differences were considered statistically significant when p < 0.05.
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PMC11476004
In the present study, tumour occurrence and the various diagnosed forms of damage to genetic material were not found to be associated with the sex of the animals.
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PMC9429973
CARD11 mutations were not detected.
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PMC5330095
Cannabidiol exhibited in vitro activity against viral hepatitis C. Cannabidiol exhibited in vitro activity against viral hepatitis C. Abbreviations Used: CB2: Cannabis receptor 2, CBD: Cannabidiol, DNA: Deoxyribonucleic acid, HBV: Hepatitis B virus, HCV: Hepatitis C virus, HIV/AIDS: Human immunodeficiency virus/acquired immune deficiency syndrome, HSC: Hepatic stellate cells, MTS: 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2Htetrazolium, PCR: Polymerase chain reactionViral hepatitis is caused by a group of viruses divided into five types (A, B, C, D, and E), and they are primarily known to attach to the liver.
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PMC9100622
A total of 24 h after being seeded, cells were pre-treated for 2 h with NAC at 3 mM before the addition of Atorvastatin (1 µM) and collected 48 h post treatment.
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PMC11530949
ROS Measurements In this study, ROS levels was significantly increased after treatment with extracts and IC50 concentrations of the Ag-doped CuO NPs compared to the control cells (P<0.01 and P<0.001, respectively).
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PMC11754432
Images were acquired using Zeiss LSM 800 Axio-Observer with Plan-Apochromat 40×/1.4 Oil DIC M27 objective and GaAsP detector.
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PMC11622247
In addition, in the single stranded state, the probe can adopt conformations that allow direct contact of the two dyes.
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PMC7841067
Silencing of AKAP4 attenuated xenografted tumor growth in nude mice.
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PMC11634027
Conversely, most Dachs:GFP clones in ds mutant wing discs had mispolarized Dachs (Fig. 5F,F′).
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PMC9429973
Results: Median age was 65,5 [27-92] years and 60,5% (75) of patients were male.
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PMC10932641
lncRNA GPRC5D-AS1 can serve as a biomarker in clinical applications and the prognosis of lung squamous cell carcinoma. •
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PMC11489351
Data presented here show that pHi changes are sufficient drivers of signaling and metabolic changes associated with pH-dependent cell behaviors.
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PMC11739670
The purified material was analyzed by SDS‐PAGE and Coomassie staining and quantified by measuring absorbance at 280 nm.
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PMC11391695
It is categorized as one of the most preponderant malignancies .
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PMC6487404
According to the FDA guidance for industry, there is an involvement of a drug efflux transporter in Caco-2 cells if the efflux ratio is ≥2 and if a significant (>50%) reduction in the efflux ratio is observed in the presence of an inhibitor of the corresponding transporter (27).
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PMC11694066
Second, the difference in PARP1 expression between our models led to discrepant observations, notably in terms of synergistic or additive cytotoxic effects of the PARPi plus ATRi combination, in which PARP1 expression and trapping play a crucial role (21, 51).
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PMC9429973
All CBCs were performed on a Sysmex XN Analyzer.
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PMC3675084
We checked the caspase-2 activation after treatment with BPR0L075, caspase-2 cleavage was not detected in both parental and resistant cells (Figure 6A, B).
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PMC9429973
A changing trend of CAR proteins from dropping to rising after encountering target cells was observed in 3 CAR-T cell group except in 8D7 CAR-T. 13C3 CAR was the most suitable construct from the perspective of basic and dynamic expression.
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PMC11317131
Delivery of large therapeutic genes such as vWF can be intractable for current methods.
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PMC11544122
Data were analyzed by Student’s t-test.
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PMC11564322
However, given the different origins of the studied cell lines, the mechanism may be slightly different.
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PMC9429973
Peripheral blood hematopoietic stem cell (PBSC) transplantation has the advantages of convenient collection, small impact on donors, good tolerance of donors and recipients, fast and durable recovery of hematopoietic function and immune function of patients after transplantation, and low transplantation-related mortality.
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PMC9429973
An elevated baseline CAR-HEMATOTOX was noted for patients with severe infections (median 5 vs. 2, p=0.002).
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PMC11643491
This distinction has broad implications for the design of targeted therapies, as it can inform the development of particles optimized for specific cell types, such as those in tumors versus healthy tissues.
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PMC11705630
Little is known regarding the function of GLDC in tumorigenesis; moreover, the function of GLDC in tumorigenesis may seemingly vary in a cancer-type dependent manner.
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PMC11449273
When co-expressed, plakoglobin resulted in a significant reduction (60%) in nuclear β-catenin levels in H1299-p53-175 and control p53-WT cells.
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PMC2944824
Brains were made hyperosmotic with sucrose and sections (25 microns) were stained for TUNEL (green) and nuclei were stained with DAPI.
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PMC9878562
Genetic deletion of ACKR3 on VAL cells had no effect on CXCR4 expression.
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PMC10237474
The preferred system to manufacture antibody and secreted protein-based therapeutics and target proteins is mammalian host cell expression, which allows the secretion of complex proteins in large quantities without the need for cell lysis.
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PMC11740508
However, clinical responses are often not durable and treatment may be detrimental in advanced cancer due to excessive toxicities.
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PMC6102174
Hsiao or A. membranaceus (Fisch.)
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PMC8873393
3Dynamic transcriptional programs of mRNAs in response to UV-C irradiation.
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PMC10812665
This again may contribute to cell death processes such as ferroptosis .
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PMC10965315
Additionally, Figure 4b demonstrates that NAC reversed the decrease in cell viability observed in harmaline‐treated cells at 24 h. These results suggest that ROS plays a significant role in harmaline‐induced cytotoxicity in A2780 cells.
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PMC11155445
A novel series of N-(phenylcarbamothioyl)-2-napthamides (129.1–129.39) were synthesized as Claudin-1 inhibitors by Mashinson et al. All synthesized compounds were investigated against colorectal cancer cells SW620.
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PMC7342409
Compared with the normal group, there was a significant decrease in the body weight of mice in the resistant group on day 0, day 3, and day 6 (p<0.05, p<0.01).
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PMC10335954
All other experiments were conducted with 3 replicates in each group.
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PMC11798926
Fluorescent immunoblot images were acquired on a Sapphire Bioimager (Azure Biosystems Model #Sapphire RGBNIR) and quantified with Azure spot software (ver 2.0).
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PMC3035438
While the parental CX13 cells are mostly IgM+ as shown previously (upper graph), 95% of the CstF-64+ cells appear IgM– (bottom graph). (
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PMC11411131
The effect of additional Krab on the MeHg sensor was examined using Krabx2-Sec, which includes TetR, Sec, and a Krab tandem repeat.
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PMC9429973
Patients with elevated Hb A2 compatible with β-thalassemia or increased Hb F were discarded.
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PMC10055960
Among the various strategies to improve selectivity, multinuclearity is often used to selectively target cancer cells through a phenomenon known as the enhanced permeability and retention (EPR) effect .
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PMC11012012
Here, it should be noted that the expression of SLAMF1/CD150 in Burkitt lymphoma could depend on the presence of Epstein–Barr virus infection.
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