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PMC6034753
After overnight incubation, caspase 3/7 reagent (1:1000) was added on cells (Essen Bioscience).
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PMC11474209
The discovery of the toxin's biosynthesis pathways paved the way for the development of molecular techniques for the early detection of microcystin.
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PMC11075223
The side chain at the C-17 is mostly an open chain with 8 carbons and its hydroxyl groups are dehydrated to form ketals or semi ketals.
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PMC9429973
Patients with hematological malignancies tend to have higher rates of COVID-19 complications and higher mortality (30% to 62%) compared to patients in the general population.
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PMC10530622
Moreover, Song and colleagues (2021) reported that the excessive autophagy activation induced by oxalate, observed from an increase of Beclin 1 and LC3-II and a decrease of p62 proteins levels, led to ferroptosis, an iron-dependent cell death (confirmed by an increase in Fe content and a decrease in glutathione peroxidase 4 protein expression), in HK-2 cells .
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PMC11750165
Previous study showed that the number of late-born neurons was limited by Jagged2-mediated Notch signaling (Yeo & Chitnis, 2007).
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PMC9429973
Because GLS is frequently activated in various types of cancer, GLS inhibitor could suppress MDS and AML cells in combination with BCL2 inhibitor.
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PMC2944824
Brains were cryoprotected in 30% sucrose overnight and frozen.
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PMC10656496
In continuation and consolidation with our previous work assessing efficacy of FDA approved and experimental chemotherapeutic compounds against osteo- and other sarcomas, we assayed an additional 100 agents bringing the total number of drugs for which we have screened against osteosarcoma to 131 (Supplemental Table 1).
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PMC11704135
Several pyrimidine derivatives have demonstrated promising antioxidant properties owing to the presence of electron-donating substituents on the pyrimidine nucleus, which augment their ability to scavenge radicals and enhance their potency.
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PMC8584319
In addition, as in the case of ERK1/2, inhibition of p38 with AZD8055 treatment resulted in the synergistic down-regulation of protein synthesis at 8 h (Figure 5a).
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PMC11347429
Demographics of cohorts.
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PMC9429973
In this study, novel functions were predicted for these ncRNAs, pointing to possible mechanisms by which their deregulation could affect AZA treatment response.
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PMC11541409
Providing evidence that the development of new TKI to overcome primary and secondary mutants is possible.
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PMC10547921
However, NAMPT inhibitors have a simple structure and high potency, and their activation mechanism is different from the current ADC payloads, so NAMPT inhibitors can be used as ADC payloads with good activity and tolerance, which is expected to improve the treatment window of NAMPT inhibitors and then be applied to the clinical environment.
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PMC11704834
The protein concentration in different fractions was measured using the Bio-Rad protein assay kit (Bio-Rad Laboratories, Inc.) with BSA (cat.
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PMC11661040
Scale bar: 200 μm. (*
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PMC10530622
Glycine is also both a precursor and a product of glyoxylate.
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PMC11532793
The first scenario is when a shared EC is dominated by a single transcript that receives all sequence reads from that EC during probabilistic assignment.
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PMC10607604
The cisplatin IC50 increased from 1.18 µM (95% CI: 0.9–1.5) in parental cells to 4.15 µM (95% CI: 3.47–4.96), 2.8 µM (95% CI: 2.38–3.3), and 2.58 µM (95% CI: 2.07–3.23) in the Kura-A2, Kura-A3, and Kura-B1 clones, respectively.
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PMC11802855
K TRAP staining of CXCL7-OE/NC RPMI8226 cell lines co-cultured with primary mouse BMDMs.
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PMC8735881
Therefore, we think that the present studies provide novel strategies for generating HIV-resistant cells, which can be used alone or with other gene therapy approaches.
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PMC11470381
The ROI is split into two halves along the minor axis (perpendicular to the major axis).
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PMC6133382
Digested samples were run on NuPAGE (Thermo Fisher, Invitrogen, Carlsbad, CA, US) 4%–12% BisTris precast gels in MES running buffer and then stained with SimplyBlue stain (Thermo Fisher, Invitrogen, Carlsbad, CA, US).
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PMC11721295
We selected the L-iKRAS cell line LC3-547 because adding dox to media resulted in sustained expression of KRAS that could be reversed by dox removal or chemically inhibited by MRTX (Figure 5, B and C).
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PMC9429973
Image: Summary/Conclusion: In the most indolent MPNs (such as ET, especially if CALR mutated) the balance and efficiency of the classical pathways is preserved.
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PMC11322866
Scale bar: 100 μm. (
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PMC9844987
We identified 1,230 promoters to be associated with at least one frQTL (5% FDR; Supplementary file 7).
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PMC11672142
Labile Fe(II) binds to a di-iron cluster site in the R2 subunit via oxidative addition, and this process generates an important tyrosyl radical located nearby.
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PMC10899471
Recently, we and others have identified basic leucine zipper transcription factor ATF-like 2 (BATF2) as a tumor suppressor (9–18).
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PMC11724582
H1975 cells treated with the negative control or CAF-CM were treated with 2 µM almonertinib for 24 h, and YAP/TAZ expression in the CAF-CM group also decreased (Fig. 5C).
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PMC11754291
P1-P2-P3 = Cell populations 1–3.
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PMC11495567
RAS proteins exert strong effects on the MAPK pathway and on the functions of other G-proteins.
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PMC9429973
Time to progression, was considered as the time to acquisition of ≥1 of the following: Hemoglobin < 10 g/dl, Leukocyte count >25 x109/L, Platelet count < 100 x109/L, Circulating blast cells ≥1%, transfusion dependency.
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PMC10669966
PDE3A-targeting compounds have recently been described as inhibiting tumor growth in mice inoculated with PDE3A-expressing cervical cancer HeLa , neuroglioma H4 , and melanoma SK-MEL-3 cells , and in patient-derived gastrointestinal stromal tumor (GIST) xenograft models .
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PMC11240571
For instance, high levels of sPD-L1 were also observed in patients diagnosed with metastatic clear-cell renal-cell carcinoma compared to those with non-metastatic disease , and sPD-L1 levels were significantly elevated in patients with muscle-invasive and metastatic bladder cancer .
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PMC11377827
H, I) As for (F, G) but for CA9 cell surface levels in HeLa cells.
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PMC11737091
All experiments were repeated three times.*,
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PMC11747949
Total metastasis burden per mouse was estimated by measuring their size and applying the following formula: volume = (D*d *π)/6, where D is the longer measurement and d is the shorter one.
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PMC11257203
Moreover, in another study conducted by Ferreira et al. the indomethacin-induced genotoxicity in tumorized male C57BL/6 mice was investigated via micronucleus assay in the bone marrow cells, and the results showed that indomethacin was genotoxic at the dose higher than 2.5 mg/kg after 5 consecutive days treatment (17).
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PMC9429973
Moreover, treating PDX cells with an ADAM10 chemical inhibitor resulted in significantly reduced engraftment capacity into the bone marrow (BM), indicating a role for ADAM10 in the early engraftment and homing process in the BM microenvironment.
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PMC9429973
Bone marrow NPM1 transcript levels after courses 1 to 4 were compared with FLT3 mutated patients receiving DAGO1 and DAGO2 without Midostaurin (Figure 1) with a higher proportion of patients becoming MRD negative from course 2 onwards and 81% being MRD negative after course 4.
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PMC11023271
LPC serves as a precursor of LPA but could also signal on its own in vivo .
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PMC9878562
In order to exclude a general inhibitory effect on VAL cell migration by ACKR3 deletion we examined the chemotaxis towards CXCL13, the ligand for CXCR5, which is expressed on both, VAL-wt and VAL-ko ( Figure 1E ).
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PMC11725127
In contrast, our results indicate that GA could inhibit USP2 activity by covalently binding to the Cys284 residue, instead of the Cys276 residue within the catalytic site, of USP2.
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PMC4485786
Scale bars: 200 µm.
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PMC11756907
The mixture was left for 24 hours at room temperature until a GO-2-ME complex was formed, and then the mixture was centrifuged (20 min, 1200 rpm) and the supernatant from the sediment was poured off.
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PMC7504302
Pemetrexed is an anticancer chemotherapy drug used in the treatment of MPM.
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PMC9429973
In addition, these BR-HMCLs also showed significant cross-resistance to Carfilzomib (Cfz) and Ixazomib (Ixa) PIs (p<0.05 for Cfz or Ixa).
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PMC10291556
6 μg of protein was used in the reaction.
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PMC11721587
The pS482 antibody only recognized the cytoplasmic but not the nuclear Ci complexes on BN-PAGE (fig. S3C), lending further support that Fu in the nuclear and cytoplasmic Ci complexes existed in different conformation.
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PMC10522430
Comparative analysis between the effects of doxorubicin and GACP extract on proinflammatory cytokine parameters demonstrated that doxorubicin had a lower impact than GACP extract on HeLa cells.
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PMC8524093
Right after the infection, frequency of innate immune cells in the peripheral blood of infected animals revealed an increase in monocytes/macrophages and all dendritic cell subset.
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PMC10502403
RNA microarray analysis was performed using cells from the four groups as in the metabolomic analysis.
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PMC11612626
E.G7-Ova cells were co-cultured with B3Z cells at an E:T ratio of 3:1 for 24 and 48 hours.
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PMC6600253
First, heat shock protein 90 (HSP90), which is a molecular chaperone that interacts with its cochaperone p23, is responsible for protein folding and the preventing of misfolding .
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PMC11412721
Flow cytometry with a combination of markers was used to discriminate the pre-B, immature, transitional, and mature B subpopulations.
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PMC11365427
Data are shown as mean ± SEM; an unpaired two-sided t-test was applied.
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PMC11345828
In addition to its direct role in regulating the apoptotic pathway, Mcl-1 is an even more attractive target as numerous studies have shown its synergistic potential when other cellular pathways, such as MAPK (Ras or MEK), mTOR, and ERK, are coinhibited.
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PMC10818573
The same false-positive phenomenon was also observed in a study of avian influenza virus detection using nfo probes , in which Wang et al. introduced probes and base substitutions to eliminate the false-positive phenomenon.
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PMC10813895
Indeed, primary myoepithelial cells cultured with the methylation inhibitor 5-aza-2′-deoxycytidine exhibited a doubling of ELF5 expression .
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PMC10376064
Permanent production of Aβ results in toxic aggregates of both NFT and Aβ, causing neurodegeneration through impairment of neurite function, disrupted synaptic communication, and disturbed cortico–cortical circuits (reviewed in ).
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PMC11805741
Accession numbers are displayed for each genus.
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PMC9429973
However, some patients are refractory or relapse after frontline therapy, and their prognosis is severely impacted by such events.
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PMC9429973
Comparison of AdvSM Subtypes: Pts with MCL had the highest transfusion requirement, with 13% and 8% of pts requiring RBC and platelet transfusions, respectively.
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PMC8097906
The labelling procedure was also described previously .
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PMC11711127
Not only does tolerance mitigate collateral damage from host immune responses, but in doing so permits a robust response sufficient to clear infection as necessary.
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PMC11782780
The impact of EBF3 on BC cell stem-like phenotype was assayed.
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PMC11592008
Our data reveal significant differences between PKs and immortalized keratinocyte cell lines in terms of functional inflammasome activation.
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PMC11746948
Scale bar, 10 μm.
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PMC11015054
GAPDH was used for normalization.
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PMC9454178
This result indicated that CDK7 might be a key driver of c-KIT expression in GIST and that it is a possible therapeutic target.
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PMC11670407
h, i 143B cells cotransfected with the indicated siRNA and overexpression plasmids for 48 h were treated with PBS or cisplatin (5, 10 or 15 μM) for 24 h. j Survival analysis of sarcoma patients in the TCGA database and GPX4 expression.
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PMC10538569
However, many hurdles, such as efficient engraftment, self-renewal, and linage cell differentiation, sustainable transgene expression, avoidance of potential insertion mutagenesis, have to be worked out in HIV-1 infection humanized mouse models or SHIV infection macaque models before the clinical efficacy of GPI-scFv X5 or GPI-HCDR3 PG16-transduced hematopoietic progenitor cells or human primary CD4 T cells can be tested in human patients.
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PMC5839394
Concerning the apoptosis, only the 11% of treated cells underwent to apoptotic cell death and accordingly, no DNA fragmentation was evident in our analysis at 24h, although the increment of Ag-DNA binding was evident after 48h of treatment.
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PMC9559528
However, the patient denied a past or present history of opportunistic infection.
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PMC11794847
Utilizing nude mouse tumorigenicity assays, our findings were consistent with the cell culture data.
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PMC11731614
Fractions 1–10 of 400ul each are concentrated to 20ul using Millipore centrifuge filters (Microcon 30kDa, MRCF0R030) and combined with one volume equivalent of BioRad 2x Lammalenni loading buffer (BioRad 1610737) with 5% BME.
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PMC11463018
H NMR (400 MHz, Chloroform-d) δ: 7.49 − 7.41 (m, 5H), 7.06 − 7.01 (m, 1H), 6.92 − 6.89 (m, 1H), 4.61 (s, 2H), 3.87 (s, 3H).
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PMC11348300
All injections and surgeries were performed under anesthesia that was induced and maintained with isoflurane.
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PMC11791203
AO, which permeates intact cell membranes, produced green fluorescence, while EB, which selectively enters cells with compromised membrane integrity and binds to DNA, emitted fluorescence ranging from yellow to orange.
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PMC10812665
The c-I inhibition also lead to a massive accumulation of NADH in the cell and an increased formation of lactate.
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PMC10813895
Notably, the expression of both isoforms diminishes with age.
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PMC10976516
Furthermore, genetic engineering of OVs will lead to new OV strains with increased oncolytic capacity and decreased pathogenicity.
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PMC10391797
Interestingly, T cell activation positively associated with the gene KLRK1(NKG2D) was involved in CD8 memory T cells in patients with AML (figure 1F), which suggests that the NKG2D–NKG2DL axis may play an important role in T cells’ memory and cytotoxicity against AML immune environments.
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PMC9429973
The median follow-up time was 4.2 months (range 0.2–15.5).
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PMC11742864
Yuanqin Yin et al. also discovered that the inhibition of AKT phosphorylation at the serine-473 site by DHA induce lung cancer cell death, further supporting the important roles of AMPK and AKT pathways.
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PMC11748335
In normal cells, DNA methylation tends to remain stable over generations.
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PMC11093197
Furthermore, the simultaneous loss of RB1 and RBL2/p130 led to increased RAS activity and upregulated expression of both c‐Myc and FTβ in MCF10A cells.
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PMC11451829
However, on day 23, a notable clinical change characterized by a decrease in the area of conjunctival hyperemia, but with an elevated lesion was observed.
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PMC11656380
Ram13 alone, without the cell-penetrating domain, lost its cytotoxicity.
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PMC9672323
GBM is considered a “cold tumor”, characterized by the lack of effector T cells in the tumor microenvironment.
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PMC11290772
This modification significantly enhanced the efficiency of NK cell maturation, resulting in improved outcomes.
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PMC9429973
JAK2V617F allele burden decreased over time (change from baseline to EOT: mean ±SD, –19.17±22.64; Median [min, max], -11.62 [-74.80,33.80]; n=26).
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PMC9429973
Maximum increase from baseline was 98 x10/L (mean), range 33-179 x10/L. Image: Summary/Conclusion: KER-050 was generally well-tolerated as of data cut-off date.
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PMC10809689
Cell lines were cultured in RPMI 1640 which supplemented with 10% FBS and 1% antibiotics.
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PMC11737091
The results were visualised via the R packages ggplot2 (v.3.4.3) and ggpubr (v.0.6.0) .
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PMC11519583
Notably, while it appeared that Wnt5a, a representative Ror1 ligand, was not implicated in Ror1-mediated signaling in SCs , the findings of the present study on MPs draw attention to the potential involvement of Wnt family protein(s) other than Wnt5a in Ror1-mediated signaling in SCs.
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PMC11676169
After centrifugation, cell lysates (diluted 1:3 with modified NETN buffer) were pre-cleared with Protein G–agarose (Santa Cruz Biotechnology) at 4 °C for 30 min before being incubated overnight with anti-FLAG M2 affinity gel beads (Sigma-Aldrich).
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PMC10495912
Reactive oxygen species The HepG2 cells were pretreated with concentrations of 18.5, 37 and 75 µM of TQ (~10-40% of IC50) before being exposed to 31.2 µM of hydrogen peroxide (~ 10% of IC50).
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