OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11394386	For this purpose, 400,000 cells were seeded in 6-well plates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "this", "purpose", ",", "400,000", "cells", "were", "seeded", "in", "6-well", ...
PMC11555465	Some infected people may have mild symptoms such as low-grade fever, headache, swelling of superficial lymph nodes, and occasionally pneumonia, pleurisy and myocarditis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The concentration ranged from 122.33 to 11617.32 pg/ml (median 2139.7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "concentration", "ranged", "from", "122.33", "to", "11617.32", "pg/ml", "(...
PMC11695623	The growth, invasion and metastasis of lung cancer is a complex and dynamic process, which involves not only the genetic abnormalities inherent in the tumor tissue, but also the interaction between the tumor tissue and immune cells in the local microenvironment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10178190	To identify soluble factors responsible for promoting chemoresistance in OC cell lines, we screened the three CM for cytokines, chemokines, and growth factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11095939	ChIP-qPCR analyses of Mecp2 at the promoter-proximal regions of Rara and Nr1h3 in Mecp2 and Mecp2-cKO livers before and 6 hr post-partial hepatectomy (PHx). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727000	Our results identified a novel association between BRCA2 and USP44, and a previously unknown role for USP44 in the Fanconi anemia DNA repair pathway that may contribute to its role in cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11695623	E–G) Correlation of DCUN1D5 with NDC1, DEPDC1, and CENPA using scatter plots. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", "–", "G", ")", "Correlation", ...
PMC11799620	OFAE extract at different concentrations for 24 hours does not affect cell viability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OFAE", "extract", "at", "different", "concentrations", "for", "24", "hours"...
PMC9927933	We then extended these in vitro cell culture observations to Kras-induced in vivo lung tumor tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "then", "extended", "these", "in", "vitro", ...
PMC9429973	Image: Summary/Conclusion: While FLC ratio ≥100 is associated with a high risk of progression in patients with SMM, it does not infer an imminent risk of progression, defined by the IMWG as median TTP of 12 months and 2-year progression rate of at least 80%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11300085	These data proved that CMKLR1 is required for chemerin-enhanced invasion as well as the activation of RhoA/ROCK1 and EMT in SK-OV-3 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "These", ...
PMC9429973	Most patients were started at an on-label BTKi dose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "patients", "were", "started", "at", "an", "on-label", "BTKi", "dose", "." ] } ]
PMC11473750	f A 3D model of RNF121 showing the location of the mutation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "f", "A", "3D", "model", "of", "RNF121", "showing", "the", "location", "of"...
PMC9429973	Future real world studies are needed to discern long-term outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Future", "real", "world", "studies", "are", "needed", "to", "discern", "long-term", "outcomes", ...
PMC11609529	GSEA showed that the YAP conserved signature, MYC target, and E2F target gene sets were negatively enriched, whereas the inflammatory response genes were positively enriched in fusion-depleted cells compared to controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11596967	Moreover, our research emphasizes the role of lmRNA in the synthesis of bioactive peptides within radiation-resistant bacteria like Deinococcus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "our", ...
PMC11271278	The presence of chimeric MYC ecDNAs may provide novel therapeutic opportunities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "presence", "of", "chimeric", "MYC", "ecDNAs", "may", "provide", "novel", "ther...
PMC11612315	Although the exact binding sites remain unclear and have not been directly confirmed by structural analyses, these findings enhance our understanding of how GLP-1-related peptides can selectively modulate TRPV1 without broad systemic effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10538569	Importantly, CD4 is a lipid raft-associated protein and richly present in the contact zone (7, 35, 36).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ...
PMC11047729	Pursuing novel therapeutic strategies that selectively target leukemic cells is critical for improving patient outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pursuing", "novel", "therapeutic", "strategies", "that", "selecti...
PMC11765879	However, they can cause serious side effects and acquire a high chance of developing drug resistance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "they", "can", "cause", "ser...
PMC11769516	The highest single toxicity was characteristic of ENNB (IC50—inhibitory concentration = 3.72 μM), followed by OTA (9.10 μM) and STG (9.99 μM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5600151	They used the tertiary amines on PAMAM for a “proton sponge” effect rather than complexing with siRNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "used", "the", "tertiary",...
PMC9429973	Randomization was stratified according to four clinical patient groups, hematological/solid cancer (group-1), treatment or disease associated immunosuppression (group 2), high risk disease by standard parameters (group-3) or age >=75 years (group-4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11781181	Acyl-CoA synthetase long-chain family member 4 (ACSL4), lysophosphatidylcholine acyltransferase 3 (LPCAT3), and arachidonate 15-lipoxygenase (ALOX15), are critical enzymes involved in the incorporation of PUFAs into phospholipids in ferroptosis 7.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9844987	p-values were determined using the Wilcoxon rank-sum test (: p<0.05; : p<0.01; **: p<0.001; NS.:	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9581083	Pharmacological studies of M. canadensis have revealed antimicrobial, anti-inflammatory, antiviral, antioxidant, antitumor, gastrointestinal protective and hepatoprotective activities (He et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11703896	Previous studies reported that, combination of rapamycin with metformin, suberoylanilide hydroxamic acid and docetaxel had significant impact on anticancer effect (Wang et al. 2021; Zang et al., 2018: Niu et al. 2011).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Endpoints included the percentage of patients with ≥35% spleen volume reduction (SVR), ≥50% modified total symptom score (mTSS) reduction, and improvement in disease symptoms measured by Patient Global Impression of Change (PGIC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: To prospectively explore the value of daratumumab plus bortezomib and dexamethasone in patients with AL amyloidosis at the advanced heart-stage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", ...
PMC11577421	The results are shown in Suppl.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "are", "shown", "in", "Suppl", "." ] } ]
PMC11634794	This suggests that LAMP1 might exert a negative feedback mechanism contributing to the downregulation of the LC3C gene expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "suggests", "that", "LAMP1...
PMC11047729	Over the past number of years, researchers around the world studied their beneficial properties, currently with a special focus concerning cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Over", ...
PMC6468656	One microgram of total RNA was reverse-transcribed using Advantage RT for PCR Kit (Clontech, Mountain View, CA, USA) at 42 °C for 1 h as described in the manufacturer’s protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11686380	Sanger sequencing analysis of the GAP43 gene of the proband, her mother, and 2 sisters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sanger", "sequencing", "analysis", "of", "the", ...
PMC7154001	Finally, 78 out of 98 articles were included in the analysis; 20 excluded articles were case reports, short communications, and articles with insufficient information.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11055510	CircRNAs can act as ceRNAs to regulate the expression of oncogenes or tumor suppressor genes at the post-transcriptional level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CircRNAs", "can", "act", "as", ...
PMC10204952	The color scheme used for the figure can also be found at the g:Profiler website.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "color", "scheme", "used", "for", "th...
PMC11422150	BBB scores were also similarly impaired before treatment: untreated SCI group = 2.94 ± 2.59 and hAMSC group = 3.09 ± 1.80.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BBB", ...
PMC11789597	Barcoded cells were pooled together and stained with metal isotope‐tagged antibodies against surface proteins and then with antibodies against intracellular proteins (Table S3, Supporting Information) after permeabilization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9352806	2Lipidomics analysis of C. elegans treated with BMS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2Lipidomics", "analysis", "of", "C.", "elegans", "treated", "with", "BMS", "." ] } ]
PMC9429973	The trial was closed prematurely after 22 patients due to inferior recruitment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "trial", "was", "closed", "prematurely", "after", "22", "patients", "due",...
PMC9429973	All patients provided informed consent.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "patients", "provided", "informed", "consent", "." ] } ]
PMC9780037	Cyt c can also be detected through the binding to a specific aptamer (represented in green) immobilized on an electrode surface.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cyt", ...
PMC11720107	Garlic-derived diallyl disulfide has been demonstrated to increase peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) expression in a ROS-dependent manner, inducing mitochondrial biogenesis at an early stage of treatment that precedes cell cycle arrest and apoptosis in the human neuroblastoma (SH-SY5Y) cell line .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461874	g The functional domains of full-length TRAF7 and the peptide which could be synthesized in TRAF7 KO cell are shown schematically.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", "The", "funct...
PMC11490153	The percentage of apoptotic cells increased under hypoxic conditions compared to normoxic conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "percentage", "of", "apoptotic", "cells", "increased", "under", "hypo...
PMC11727000	Subsequently, we and others have found USP44 to contribute to the pathophysiology of several cancers, with roles as an oncogene and tumor suppressor depending on the cellular context of its deregulation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11406030	In a recent study, LMTK3 was reported to promote chemoresistance to cetuximab in colorectal cancer via the extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8343815	Our toxicity assessment of different concentrations of AuNRs and AuNPs showed that AuNRs are markedly more toxic than AuNPs on the HeLa cell line (Figure-1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC9429973	Patients belonging to the submono-nucleosomal cluster had different clinical and biological nuances, including advanced stage, B-symptoms, elevated ESR, higher TMTV and total lesion glycolysis, higher mutation load, higher circulating immune suppressive cytokines and chemoattractants for monocytes and Th-cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806182	Valproic acid, an HDAC inhibitor , demonstrated the ability to down-regulate nucleoplasm components, potentially suppressing gene expression or cell division, while simultaneously up-regulating cell junction integrity, which may enhance cellular adhesion and slow cancer cell dissemination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10538569	Taken together, these results suggest that expression of GPI-scFv X5 in neighboring T cells has the capacity to block HIV-1 replication in trans in iDCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11155445	Studies showed that these thioureas proved as good DNA binders through mixed types of interactions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Studies", "showed", "that", "these", "thioureas", "proved", ...
PMC11727000	We first examined event-free survival in the SEQC cohort (n = 498) for patients with high (>median) or low (<median) BRCA2 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11243198	Our qRT-PCR data confirmed that two analogs (BAS 07019774 and Z27610715) significantly inhibited Gli1 mRNA expression in Hh-responsive C3H10T1/2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Our", ...
PMC11635519	Next, we added 50 μL of working solution to each well containing the cell medium (Pierce Gaussia-Firefly Luciferase Dual Assay Kit, Thermo Scientific #16181).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11459296	A total of 5×10 PB-MNCs or CB-MNCs were transplanted intravenously into sublethally irradiated (2 Gy) mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "5"...
PMC6364197	We hypothesize that the collagen type I promote the Jurkat cells to harbor in the 3-D niche of the scaffold and activate the DDR1 protein as a ligand.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11618052	0.51 (hexane : ethyl acetate, 1 : 2, v/v).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "0.51", "(", "hexane", ":", "ethyl", "acetate", ",", "1", ":", "...
PMC9429973	However, the quality of such initiatives can be poor due to the need for manual data entry, inability to integrate multiple data sources, lack of harmonisation of data across centres and limited generalisability due to centre bias.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11802929	Note that even the weak-binders are relatively good candidates compared to peptides that were not attempted for SCT expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Note", "that", "even", "the", ...
PMC11790971	Enhanced classification performance was observed for passage 1 and passage 2 when using all test set cells from these passages (Fig. 2d–f).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC3164356	Several other CAMs like CD48 and CD2 are also not expressed in the CHO-K1 transcriptome data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Several", "other", "CAMs", "like", "CD48", "a...
PMC11194678	The LysoTracker Red staining (Beyotime) and LysoSensor Green DND-189 (Meilun) were performed to measure the presence of acid compartments (such as lysosomes).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: The level of protein C and S is lower in COVID-19 patients with thrombosis compared with patients without thrombotic complication (median value: protein S: 43.5 (8-102) vs. 56 (18-144), p=0.05; protein C: 71 (15-169) vs. 95 (16-200), p=0.02).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6461034	Acidify the digest by adding 1/20 volume 20% TFA (final concentration 1%).Invert sample, vortex for 5 s, and incubate on ice for 15 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10547921	Antibody‒drug conjugates (ADCs), which combine the advantages of monoclonal antibodies with precise targeting and payloads with efficient killing, show great clinical therapeutic value.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5673955	N = 4. *	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "N", "=", "4", ".", "*" ] } ]
PMC11453018	Thus, knockdown of P300/CBP by RNAi emphasizes its indispensable role within the EWS::FLI1 transcriptional axis and in maintaining ES cell viability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", ...
PMC11515150	Cells were counted via trypan blue staining every other day.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "counted", "via", "trypan", "blue", "staining", "every", "other", "day", "...
PMC6643347	Nevertheless, viral replication, in addition, takes place in quiescent CD4-positive memory cells, which also contain latently integrated or pre-integrated proviral DNA .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10237474	These results suggest that the high VCD of Expi293F GnTI observed during production harvest (Fig 3D) was generally translatable to high expression titer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	In a pooled analysis of the COMFORT I and II trials of ruxolitinib (RUX), patients (pts) who received RUX at randomization or after crossover from placebo (PBO) or best available therapy (BAT) had improved OS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10213179	The EphA2-ephrin interaction initiates the established EphA2 signaling cascade.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "EphA2-ephrin", "interaction", "initiates", "the", "established", "EphA2", "signaling", "cascade", "....
PMC5363531	These findings agree with previous in vitro studies reporting that the pretreatment with rapamycin increases PEM activity reducing TS protein expression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", ...
PMC9429973	Methods: Gene expression profile of 18 R/R B-ALL patient samples was analyzed with RNA-seq, before InO exposure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Gene", "expressio...
PMC11726848	The protein was used to contrast and more accurately determine the boundaries and sizes of the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", "was", "used", "to", "cont...
PMC10823017	There are fifteen types of PKCs found in humans, placed in three categories (classical, novel, and atypical PKCs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There",...
PMC11791203	IC50Values of chloroform and petroleum ether extracts on HT29 and HaCaT cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "IC50Values", "of", "chloroform", "and", "petroleum", "ether", "...
PMC9429973	At any combination of PCR response, FLAG-GO treated patients had lower hazards for relapse than FLAG-IDA treated pts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "any", "combination", "of", ...
PMC9429973	The percentage of correctly predicted HI-P was highest for the model, which included the variables platelet count, SRSF2 mutation status and the hemoglobin level using the threshold of 11.4 g/dl and resulted in an overall accuracy of 70 % for a correct ROM response prediction (Figure 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	While mostly variants of structural proteins of the erythrocyte membrane (i.e. ANK1 (ankyrin), SLC4A1 (band 3), SPTA1 (α-spectrin) or SPTB (β-spectrin)) can be causative for the phenotype, only the minority of patients have been genetically characterized so far.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The combination of chidamide with ABT-199 significantly increases the rate of cell proliferation arrest (Fig. 1A), and apoptosis (Fig. 1B) compared to the single drug control in both cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615218	Strategies to promote naive and early memory populations in CAR-T cell manufacturing are being investigated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Strategies", "to", "promote", "naive", "and", "early", "mem...
PMC7582629	The RS has been used to differentiate leukocytes from the peripheral blood samples by detecting the intrinsic biochemical components of the same. .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9429973	This method combines high resolution with picturing almost whole chromosomes without cell cultivation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "method", "combines", "high", "resolution", "with", "picturing", "al...
PMC11033180	∗p < 0.05 Kruskal-Wallis test, supplemented by Dunn’s post-hoc test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "∗p", "<", "0.05", "Kruskal-Wallis", "test", ",", "supplemented", "by", "Dunn", ...
PMC11237030	Representative immunofluorescence images showing the distribution of AQP5 in (a) untreated and (b) 24 h cpt-cAMP treated CHO-K1/AQP5 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Represe...
PMC9429973	This subgroup of leukaemia remains poorly characterized.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "subgroup", "of", "leukaemia", "remains", "poorly", "characterized", "." ] } ]
PMC9985266	Overexpression of DNMT1, knockdown of lncRNA MEG3, autophagy inhibitor or ERK/p38 signaling pathway inhibitors reversed the positive effect of IL-27 in a lung fibrosis model in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11469524	BL-2 and BL-41 information retained from models trained on the BL-2 structure and with inhibitor strength fixed to BL-2 model (Fig 2E and S1 Table), the connection for GSK3 to Btk was retrieved by multiplying the coefficients r_ZAP70_GSK3A.B with r_Btk_ZAP70.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9386809	Complex 2 is monomeric, and the coordination polyhedron is formed by the chelation of two nitrogen atoms of the dianionic BPC ligand 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11407042	Besides, High absorbance for the background may also be ascribed to cell death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Besides", ",", "High", "absorbance", "for", "the", "background", ...
PMC11604015	Therefore, there is an urgent need to develop novel and effective therapies for this type of malignant disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "there", "is", ...
PMC10748106	In addition, all the experimental values of the cytotoxic activity against the HeLa cell line (IC50) are shown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition...
PMC9429973	We used the results of this survey to inform the selection of a shortlist of questions for inclusion at the final consensus-building workshop.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", ...
PMC11547972	SFN has recently been declared one of the “Big Five” phytochemicals targeting cancer stem cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SFN", "has", "recently", "been", "declared", ...
PMC11706491	At S phase, Cdt1 is degraded by the SCF complex, and geminin accumulation gives cells a green fluorescence, which persists until metaphase when geminin is degraded via APC/C .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11394386

For this purpose, 400,000 cells were seeded in 6-well plates.

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PMC11555465

Some infected people may have mild symptoms such as low-grade fever, headache, swelling of superficial lymph nodes, and occasionally pneumonia, pleurisy and myocarditis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The concentration ranged from 122.33 to 11617.32 pg/ml (median 2139.7).

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PMC11695623

The growth, invasion and metastasis of lung cancer is a complex and dynamic process, which involves not only the genetic abnormalities inherent in the tumor tissue, but also the interaction between the tumor tissue and immune cells in the local microenvironment.

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PMC10178190

To identify soluble factors responsible for promoting chemoresistance in OC cell lines, we screened the three CM for cytokines, chemokines, and growth factors.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11095939

ChIP-qPCR analyses of Mecp2 at the promoter-proximal regions of Rara and Nr1h3 in Mecp2 and Mecp2-cKO livers before and 6 hr post-partial hepatectomy (PHx). (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11727000

Our results identified a novel association between BRCA2 and USP44, and a previously unknown role for USP44 in the Fanconi anemia DNA repair pathway that may contribute to its role in cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11695623

E–G) Correlation of DCUN1D5 with NDC1, DEPDC1, and CENPA using scatter plots. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", "–", "G", ")", "Correlation", ...

PMC11799620

OFAE extract at different concentrations for 24 hours does not affect cell viability.

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PMC9927933

We then extended these in vitro cell culture observations to Kras-induced in vivo lung tumor tissues.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "then", "extended", "these", "in", "vitro", ...

PMC9429973

Image: Summary/Conclusion: While FLC ratio ≥100 is associated with a high risk of progression in patients with SMM, it does not infer an imminent risk of progression, defined by the IMWG as median TTP of 12 months and 2-year progression rate of at least 80%.

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PMC11300085

These data proved that CMKLR1 is required for chemerin-enhanced invasion as well as the activation of RhoA/ROCK1 and EMT in SK-OV-3 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "These", ...

PMC9429973

Most patients were started at an on-label BTKi dose.

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PMC11473750

f A 3D model of RNF121 showing the location of the mutation.

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PMC9429973

Future real world studies are needed to discern long-term outcomes.

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PMC11609529

GSEA showed that the YAP conserved signature, MYC target, and E2F target gene sets were negatively enriched, whereas the inflammatory response genes were positively enriched in fusion-depleted cells compared to controls.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11596967

Moreover, our research emphasizes the role of lmRNA in the synthesis of bioactive peptides within radiation-resistant bacteria like Deinococcus.

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PMC11271278

The presence of chimeric MYC ecDNAs may provide novel therapeutic opportunities.

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PMC11612315

Although the exact binding sites remain unclear and have not been directly confirmed by structural analyses, these findings enhance our understanding of how GLP-1-related peptides can selectively modulate TRPV1 without broad systemic effects.

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PMC10538569

Importantly, CD4 is a lipid raft-associated protein and richly present in the contact zone (7, 35, 36).

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PMC11047729

Pursuing novel therapeutic strategies that selectively target leukemic cells is critical for improving patient outcomes.

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PMC11765879

However, they can cause serious side effects and acquire a high chance of developing drug resistance .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "they", "can", "cause", "ser...

PMC11769516

The highest single toxicity was characteristic of ENNB (IC50—inhibitory concentration = 3.72 μM), followed by OTA (9.10 μM) and STG (9.99 μM).

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PMC5600151

They used the tertiary amines on PAMAM for a “proton sponge” effect rather than complexing with siRNA.

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PMC9429973

Randomization was stratified according to four clinical patient groups, hematological/solid cancer (group-1), treatment or disease associated immunosuppression (group 2), high risk disease by standard parameters (group-3) or age >=75 years (group-4).

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PMC11781181

Acyl-CoA synthetase long-chain family member 4 (ACSL4), lysophosphatidylcholine acyltransferase 3 (LPCAT3), and arachidonate 15-lipoxygenase (ALOX15), are critical enzymes involved in the incorporation of PUFAs into phospholipids in ferroptosis 7.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9844987

p-values were determined using the Wilcoxon rank-sum test (*: p<0.05; **: p<0.01; ***: p<0.001; NS.:

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PMC9581083

Pharmacological studies of M. canadensis have revealed antimicrobial, anti-inflammatory, antiviral, antioxidant, antitumor, gastrointestinal protective and hepatoprotective activities (He et al., 2019).

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PMC11703896

Previous studies reported that, combination of rapamycin with metformin, suberoylanilide hydroxamic acid and docetaxel had significant impact on anticancer effect (Wang et al. 2021; Zang et al., 2018: Niu et al. 2011).

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PMC9429973

Endpoints included the percentage of patients with ≥35% spleen volume reduction (SVR), ≥50% modified total symptom score (mTSS) reduction, and improvement in disease symptoms measured by Patient Global Impression of Change (PGIC).

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PMC9429973

Aims: To prospectively explore the value of daratumumab plus bortezomib and dexamethasone in patients with AL amyloidosis at the advanced heart-stage.

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PMC11577421

The results are shown in Suppl.

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PMC11634794

This suggests that LAMP1 might exert a negative feedback mechanism contributing to the downregulation of the LC3C gene expression.

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PMC11047729

Over the past number of years, researchers around the world studied their beneficial properties, currently with a special focus concerning cancers.

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PMC6468656

One microgram of total RNA was reverse-transcribed using Advantage RT for PCR Kit (Clontech, Mountain View, CA, USA) at 42 °C for 1 h as described in the manufacturer’s protocol.

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PMC11686380

Sanger sequencing analysis of the GAP43 gene of the proband, her mother, and 2 sisters.

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PMC7154001

Finally, 78 out of 98 articles were included in the analysis; 20 excluded articles were case reports, short communications, and articles with insufficient information.

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PMC11055510

CircRNAs can act as ceRNAs to regulate the expression of oncogenes or tumor suppressor genes at the post-transcriptional level.

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PMC10204952

The color scheme used for the figure can also be found at the g:Profiler website.

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PMC11422150

BBB scores were also similarly impaired before treatment: untreated SCI group = 2.94 ± 2.59 and hAMSC group = 3.09 ± 1.80.

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PMC11789597

Barcoded cells were pooled together and stained with metal isotope‐tagged antibodies against surface proteins and then with antibodies against intracellular proteins (Table S3, Supporting Information) after permeabilization.

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PMC9352806

2Lipidomics analysis of C. elegans treated with BMS.

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PMC9429973

The trial was closed prematurely after 22 patients due to inferior recruitment.

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PMC9429973

All patients provided informed consent.

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PMC9780037

Cyt c can also be detected through the binding to a specific aptamer (represented in green) immobilized on an electrode surface.

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PMC11720107

Garlic-derived diallyl disulfide has been demonstrated to increase peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) expression in a ROS-dependent manner, inducing mitochondrial biogenesis at an early stage of treatment that precedes cell cycle arrest and apoptosis in the human neuroblastoma (SH-SY5Y) cell line .

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PMC11461874

g The functional domains of full-length TRAF7 and the peptide which could be synthesized in TRAF7 KO cell are shown schematically.

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PMC11490153

The percentage of apoptotic cells increased under hypoxic conditions compared to normoxic conditions.

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PMC11727000

Subsequently, we and others have found USP44 to contribute to the pathophysiology of several cancers, with roles as an oncogene and tumor suppressor depending on the cellular context of its deregulation .

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PMC11406030

In a recent study, LMTK3 was reported to promote chemoresistance to cetuximab in colorectal cancer via the extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway in vitro.

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PMC8343815

Our toxicity assessment of different concentrations of AuNRs and AuNPs showed that AuNRs are markedly more toxic than AuNPs on the HeLa cell line (Figure-1).

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PMC9429973

Patients belonging to the submono-nucleosomal cluster had different clinical and biological nuances, including advanced stage, B-symptoms, elevated ESR, higher TMTV and total lesion glycolysis, higher mutation load, higher circulating immune suppressive cytokines and chemoattractants for monocytes and Th-cells.

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PMC11806182

Valproic acid, an HDAC inhibitor , demonstrated the ability to down-regulate nucleoplasm components, potentially suppressing gene expression or cell division, while simultaneously up-regulating cell junction integrity, which may enhance cellular adhesion and slow cancer cell dissemination.

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PMC10538569

Taken together, these results suggest that expression of GPI-scFv X5 in neighboring T cells has the capacity to block HIV-1 replication in trans in iDCs.

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PMC11155445

Studies showed that these thioureas proved as good DNA binders through mixed types of interactions.

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PMC11727000

We first examined event-free survival in the SEQC cohort (n = 498) for patients with high (>median) or low (<median) BRCA2 expression.

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PMC11243198

Our qRT-PCR data confirmed that two analogs (BAS 07019774 and Z27610715) significantly inhibited Gli1 mRNA expression in Hh-responsive C3H10T1/2 cells.

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PMC11635519

Next, we added 50 μL of working solution to each well containing the cell medium (Pierce Gaussia-Firefly Luciferase Dual Assay Kit, Thermo Scientific #16181).

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PMC11459296

A total of 5×10 PB-MNCs or CB-MNCs were transplanted intravenously into sublethally irradiated (2 Gy) mice.

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PMC6364197

We hypothesize that the collagen type I promote the Jurkat cells to harbor in the 3-D niche of the scaffold and activate the DDR1 protein as a ligand.

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PMC11618052

0.51 (hexane : ethyl acetate, 1 : 2, v/v).

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PMC9429973

However, the quality of such initiatives can be poor due to the need for manual data entry, inability to integrate multiple data sources, lack of harmonisation of data across centres and limited generalisability due to centre bias.

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PMC11802929

Note that even the weak-binders are relatively good candidates compared to peptides that were not attempted for SCT expression.

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PMC11790971

Enhanced classification performance was observed for passage 1 and passage 2 when using all test set cells from these passages (Fig. 2d–f).

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PMC3164356

Several other CAMs like CD48 and CD2 are also not expressed in the CHO-K1 transcriptome data.

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PMC11194678

The LysoTracker Red staining (Beyotime) and LysoSensor Green DND-189 (Meilun) were performed to measure the presence of acid compartments (such as lysosomes).

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PMC9429973

Results: The level of protein C and S is lower in COVID-19 patients with thrombosis compared with patients without thrombotic complication (median value: protein S: 43.5 (8-102) vs. 56 (18-144), p=0.05; protein C: 71 (15-169) vs. 95 (16-200), p=0.02).

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PMC6461034

Acidify the digest by adding 1/20 volume 20% TFA (final concentration 1%).Invert sample, vortex for 5 s, and incubate on ice for 15 min.

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PMC10547921

Antibody‒drug conjugates (ADCs), which combine the advantages of monoclonal antibodies with precise targeting and payloads with efficient killing, show great clinical therapeutic value.

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PMC5673955

N = 4. *

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PMC11453018

Thus, knockdown of P300/CBP by RNAi emphasizes its indispensable role within the EWS::FLI1 transcriptional axis and in maintaining ES cell viability.

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PMC11515150

Cells were counted via trypan blue staining every other day.

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PMC6643347

Nevertheless, viral replication, in addition, takes place in quiescent CD4-positive memory cells, which also contain latently integrated or pre-integrated proviral DNA .

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PMC10237474

These results suggest that the high VCD of Expi293F GnTI observed during production harvest (Fig 3D) was generally translatable to high expression titer.

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PMC9429973

In a pooled analysis of the COMFORT I and II trials of ruxolitinib (RUX), patients (pts) who received RUX at randomization or after crossover from placebo (PBO) or best available therapy (BAT) had improved OS.

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PMC10213179

The EphA2-ephrin interaction initiates the established EphA2 signaling cascade.

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PMC5363531

These findings agree with previous in vitro studies reporting that the pretreatment with rapamycin increases PEM activity reducing TS protein expression .

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PMC9429973

Methods: Gene expression profile of 18 R/R B-ALL patient samples was analyzed with RNA-seq, before InO exposure.

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PMC11726848

The protein was used to contrast and more accurately determine the boundaries and sizes of the cells.

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PMC10823017

There are fifteen types of PKCs found in humans, placed in three categories (classical, novel, and atypical PKCs).

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PMC11791203

IC50Values of chloroform and petroleum ether extracts on HT29 and HaCaT cell lines.

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PMC9429973

At any combination of PCR response, FLAG-GO treated patients had lower hazards for relapse than FLAG-IDA treated pts.

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PMC9429973

The percentage of correctly predicted HI-P was highest for the model, which included the variables platelet count, SRSF2 mutation status and the hemoglobin level using the threshold of 11.4 g/dl and resulted in an overall accuracy of 70 % for a correct ROM response prediction (Figure 1A).

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PMC9429973

While mostly variants of structural proteins of the erythrocyte membrane (i.e. ANK1 (ankyrin), SLC4A1 (band 3), SPTA1 (α-spectrin) or SPTB (β-spectrin)) can be causative for the phenotype, only the minority of patients have been genetically characterized so far.

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PMC9429973

The combination of chidamide with ABT-199 significantly increases the rate of cell proliferation arrest (Fig. 1A), and apoptosis (Fig. 1B) compared to the single drug control in both cell lines.

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PMC11615218

Strategies to promote naive and early memory populations in CAR-T cell manufacturing are being investigated.

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PMC7582629

The RS has been used to differentiate leukocytes from the peripheral blood samples by detecting the intrinsic biochemical components of the same. .

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PMC9429973

This method combines high resolution with picturing almost whole chromosomes without cell cultivation.

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PMC11033180

∗p < 0.05 Kruskal-Wallis test, supplemented by Dunn’s post-hoc test.

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PMC11237030

Representative immunofluorescence images showing the distribution of AQP5 in (a) untreated and (b) 24 h cpt-cAMP treated CHO-K1/AQP5 cells.

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PMC9429973

This subgroup of leukaemia remains poorly characterized.

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PMC9985266

Overexpression of DNMT1, knockdown of lncRNA MEG3, autophagy inhibitor or ERK/p38 signaling pathway inhibitors reversed the positive effect of IL-27 in a lung fibrosis model in vitro.

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PMC11469524

BL-2 and BL-41 information retained from models trained on the BL-2 structure and with inhibitor strength fixed to BL-2 model (Fig 2E and S1 Table), the connection for GSK3 to Btk was retrieved by multiplying the coefficients r_ZAP70_GSK3A.B with r_Btk_ZAP70.

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PMC9386809

Complex 2 is monomeric, and the coordination polyhedron is formed by the chelation of two nitrogen atoms of the dianionic BPC ligand 1.

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PMC11407042

Besides, High absorbance for the background may also be ascribed to cell death.

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PMC11604015

Therefore, there is an urgent need to develop novel and effective therapies for this type of malignant disease.

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PMC10748106

In addition, all the experimental values of the cytotoxic activity against the HeLa cell line (IC50) are shown.

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PMC9429973

We used the results of this survey to inform the selection of a shortlist of questions for inclusion at the final consensus-building workshop.

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PMC11547972

SFN has recently been declared one of the “Big Five” phytochemicals targeting cancer stem cells .

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PMC11706491

At S phase, Cdt1 is degraded by the SCF complex, and geminin accumulation gives cells a green fluorescence, which persists until metaphase when geminin is degraded via APC/C .

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