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OTAR3088
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BioData-CellLine_annotated

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PMC11632064
Pie chart associating a functional category (g:Profiler) to 197 metabolic transcripts that are repressed in A-375 cells treated with LJH685 for 72 h compared to DMSO. (
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PMC6034753
Nuclear co-localisation of the two viral proteins was also demonstrated in transfected DF-1 cells, an immortalized chicken embryo fibroblast-derived cell line (Figure 1B).
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PMC10587429
These humanized mice harbor human hematopoietic and immune cells and are considered a feasible and ideal model to study cancer immunology and evaluate cancer immunotherapy.
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PMC11718031
As cell viability dropped dramatically after day 8, the mAb concentrations on day 6 and day 8 were compared.
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PMC11655498
EBV-encoded BNRF1 membrane protein degrades the SMC5/6 complex through calpain proteolysis and the E3 ubiquitin ligase Cullin-7 dependent proteasome degradation pathway, allowing EBV to escape host restriction on viral genome replication and the production of infectious progeny virions (Yiu et al., 2022).
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PMC5035325
Moreover, we perform an initial evaluation of the therapeutic implications of targeting simultaneously both molecules, in lung models.
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PMC11089031
B qPCR tested the effects of KD and OE in the Caki-1 cell line.
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PMC11352311
Specifically, esculin binds to GAPDH via the binding sites SER-51, ASN-287, LEU-203, and PRO-236; to TNF via MET-1; to CCND1 via ASN-174, ARG-218, SER-219, and ASN-211/222; to GSK3B via ASN-64, ASP-200, and VAL-135; to MCL1 via ARG-263; to CDK2 via LYS-33, HIS-84, and ASP-86; and to IL2 via ASP-40, HIS-36, GLN-33, and LYS-29.
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PMC9503669
This Nef function has been implicated in HIV persistence and correlates with reservoir size in patient samples .
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PMC11400680
The detailed settings of the YOLOv9-E model are stated in Table 2.
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PMC9429973
Cytogenetic risk classification was poor-risk in 33 (37.9%) and intermediate-risk in 45 (51.7%) patients.
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PMC10747160
It is our hope that this work will assist with the development of Griffithsin variants and prophylactic protocols that can be rapidly deployed against future SARS-CoV-2 strains.
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PMC10033453
Comparison of VSV, Morreton virus (MorV), and VMG cytotoxicity in A673 cells at MOI 0.1 analyzed in the IncuCyte S3 System. (
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PMC11583690
Regarding paclitaxel, a taxane that is structurally similar to DTX, Mai and colleagues assessed BPMO biodegradability, loading capability, and in vitro cytotoxicity.
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PMC10204952
CAA-CM could enhance the proliferative effect of S1P at concentrations between 100 and 1000 nM. Cell viability of the MCF-12A cells was significantly increased (p < 0.05) at 1000 nM S1P for both 48 h and 72 h treatments and 100 nM S1P for 72 h treatment.
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PMC9777812
Simultaneously, Cyclin D, CDK4, Cyclin E, and CDK2 were significantly promoted (Figure 6C; p < 0.05, p < 0.01).
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PMC9429973
Of 53 clinical relapses with MRD results available, 42 were preceded by pos MRD (>0.1%) with a median of 70 (range 20-425) days between first pos MRD and clinical relapse.
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PMC10674574
The in vitro transport studies based on the protocols described by Tavelin and Hubatsch are widely used in permeability research.
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PMC9429973
Overall survival (OS) and progression free survival (PFS) were assessed using time-dependent, competitive risk analysis.
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PMC11261875
In the context of GIST, there is a growing body of evidence suggesting that this cancer-specific metabolic paradigm influences tumor malignancy, tumor risk stratification, and resistance to imatinib [, , ].
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PMC11628904
Image acquisition was performed using Nikon NIS‐Elements software.
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PMC9429973
The first four months, a SRBC immune booster was performed to maintain the GCs.
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PMC6442998
PDE3A immunoreactivity was detected in 92% of human GIST samples.
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PMC10114490
HDF-T were then infected with a 1:1 mix of lentiviral vectors TetO-HHFG and rtTA and single-cell cloned as described above.
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PMC9014716
Afterward, the absorbance of each well was calculated at a wavelength of 450 nm using a microplate reader (Model 680; Bio-Rad Laboratories, Hercules, CA, USA).
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PMC9429973
Inverse probability of treatment weighting with average treatment effect on the treated population was used to adjust for imbalances in baseline covariates of prognostic significance such as International Staging System stage, number of prior LOT, extramedullary plasmacytoma, time since diagnosis, age, hemoglobin, cytogenetic risk, refractory status and progression on last LOT.
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PMC9429973
Telemedicine.
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PMC11575040
RNA samples were processed using a strand-specific transcriptome preparation protocol and sequenced using an Illumina platform (Illumina, San Diego, CA, USA).
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PMC9429973
Instead, among down-regulated, there were putative suppressors involved in genome stability, i.e. BRCA1, FANCI, BRIP1, XRCC2, and CHEK1.
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PMC11435360
Neovascularization is another critical process in cancer progression, in which H2S is a key mediator .
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PMC11596967
Therefore, exploring the genomes of radiation-resistant bacteria such as Deinococcus for short lmRNAs ranging from 15 to 45 nucleotides could pave the way for discovering new AOPs.
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PMC9895440
The Biolegend Legendplex analysis online tool was used to calculate concentrations according to internal standards.
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PMC9429973
Aims: We aim to investigate the function of STAT3 in AML evasion from NK cell surveillance.
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PMC11661024
In addition, the expression of iKB and RelA genes was also evaluated by q-PCR, showing a 0.5-fold reduction of these gene expressions compared to the control (Fig. 3).
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PMC11345828
Toluene (80 mL) and THF (80 mL) were added and the reaction mixture was sparged with argon for 5 min.
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PMC11495567
NCI-H23 cells were treated for 48 h with 0−5 μM of the PCAIs (NSL-YHJ-x-xx where x-xx is 2–27 or 2–46) or 5 μM of its non-farnesylated control analog, NSL-YHJ-x-xx (where x-xx is 2–62).
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PMC11587541
Statistical analysis was performed on IBM SPSS statistics 20 software.
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PMC10421378
For uncoated samples in particular, both variants had a prolonged shelf-life of 9 months compared with the 6 months for samples in contact with air.
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PMC10243817
Finally, we explored the expression of identified core collagen genes in different CRS subtypes.
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PMC4355729
Individual mutation and mutational spectra were obtained from Sanger sequence.
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PMC9065483
Heatmaps of relative gene expression were generated using the R-studio pheatmap package.
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PMC11495567
Bright field and fluorescent images of cells exposed to 0.5 μM of the PCAIs indicate that the bulk of cells remained attached yet rounded.
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PMC9822769
Cisplatin was dissolved in a 0.9% w/v NaCl aqueous solution and brought to pH = 3 with HCl (final stock concentration 1 mM).
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PMC2777936
In these analyses PORCN, FRAT2, and FZD5 were each repressed following POU5F1 targeted repression, but this did not achieve statistical significance.
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PMC6312945
The expression of HbsAg was detected using ELISA.
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PMC11537649
After resistance, the condition of malignant melanoma progresses explosively and there are currently almost no drugs that can effectively control it.
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PMC9621239
In total, the HBx mutants with triple mutation T81P/S101P/L123s arise more frequently in the liver tumour tissues, indicating their potential role in HCC progression.
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PMC6190245
extracts suppressed gastric cancer cells’ proliferation through apoptosis induction (Gharaei et al., 2013 ▶).
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PMC9429973
Aims: To discuss the significance of MRD detection by MFC with cytoplastic CD79a(cCD79a) gating panel in relapsed or refractory B-cell acute lymphoblastic leukemia(r/r B-ALL) and evaluate its value for prognosis in CD19-CAR-T bridging to allogeneic-hematopoietic stem cell transplantation (allo-HSCT).
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PMC9429973
The combination of BPD will be an effective treatment strategy in RRMM with EMD.
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PMC11363012
External calibration curves were generated using authentic standards.
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PMC11015054
The upper layer of the cells were collected from the chambers after 3 days of cultivation for subsequent experiments.
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PMC11730311
However, pharmacokinetics of lipidated analogues of hαCGRP8-37 pharmacokinetics has not been explored.
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PMC11562028
This indicates that the toxic effect of the Re-CDs on mice was very low.
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PMC9429973
The median PS is 2 (range 0-3) and in the R/R cohort, the median number of prior treatments is 2 (range, 1-4).
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PMC11806182
Exosomal miRNAs are also important as biomarkers for cancer progression and immune evasion, offering potential targets for therapeutic intervention .
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PMC11733919
A calibration curve was performed with 17-AAG or 17-DMAG (serial dilutions from 0 to 125 μg/mL), and the absorbance was recorded at 333 and 331 nm (maximum absorption peaks, respectively) in a UV–VIS–NIR spectrophotometer (V-670, JASCO, Madrid, Spain).
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PMC3019555
These data, together with our own observations, prompted us to investigate the potential involvement of P-bodies in the microtubule-dependent repression of HIF-1α translation.
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PMC11638255
Cells were incubated with CD3ε-FITC (clone 145-2C11, 1:100, Thermo Fisher Scientific, USA; #11-0031-82, Lot 231864), NK1.1-PE (clone PK136, 1:200, Thermo Fisher Scientific, USA; #12-5941-82, Lot 2142869) and CD11b-BV421 (clone M1/70, 1:200, BioLegend, USA; #101251, Lot B322058).
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PMC9895440
f Percentage of SNX9+ cells among CD8 T cells for each sample before treatment with ICI.
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PMC5600151
Later, Patil et al. conjugated luteinizing hormone-releasing hormone (LHRH) as a cancer targeting moiety to deliver siBCL-2 to show efficient cancer cell penetration and low cytotoxicity.
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PMC10297204
In this study, the anti-tumor effect of ethanol, as well as its neurotoxicity, were assessed.
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PMC10957991
In addition to its involvement in the control of cell adhesion proteins, TRPV4 can fine-tune organization of actin cytoskeleton and contractile features through changes in the calcium homeostasis at least in the cardiomyocytes, smooth muscle and vascular endothelial cells.
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PMC11727145
Specifically, these future works will investigate primary dermal fibroblast and keratinocyte combinations with a burn wound model, with exudates collected from wounds of different burn degrees and surfaces.
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PMC11676670
We expanded the comparison by incorporating key aspects of cell line characteristics, including patient diagnosis, origin of the cell line, mutational burden and chromosomal instability, proliferation and migration rates, and epithelial–mesenchymal transition status (Table 1).
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PMC11789597
Mass cytometry was employed to measure the phosphorylation level of pathway proteins and key proteins that regulate glucose and energy metabolism at the single‐cell level.
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PMC2196094
Mucosal MCs (MMCs), which are found mainly in the lung and the intestinal mucosae, contain predominantly chondroitin sulfate proteoglycan (6, 7), do not stain with safranin and contain comparably low amounts of histamine (8).
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PMC9429973
Many studies reported that about 50% of patients can achieve sustained treatment free remission (TFR) while 50% present with molecular disease recurrence, typically within two years of stopping.
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PMC11612626
Currently, the immunopeptidome can be defined by MS methods.
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PMC11754784
RPMI-CEM, Ramos, K562, RPMI-8226 and Jurkat cells were incubated with 100 nM DNPs (DNP1, DNP2 and DNP3) for 1 h at 37 °C.
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PMC11743414
Moreover, a large number of studies have demonstrated that the downregulation of FHL1 is altered in a variety of tumors and is involved in the occurrence and development of these diseases, including lung , gastric , and breast, kidney, and prostate cancers .
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PMC11377827
The ability of USP43 levels to influence HIF-1α levels on chromatin suggested that a further protein or signal was involved.
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PMC9429973
Many human neoplasms show unscheduled MYC expression and it is important in pathogenesis of some lymphomas.
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PMC11064533
The data are shown as median values and MAD of three different experiments with three replicates.
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PMC9960565
Interestingly, a trend in cytotoxicity was not observed with the increase in dendrimer generation (increased number of metallic centers).
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PMC11185260
Treatment schedule.
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PMC9599726
We observed that Lip had a minor effect on viability reduction induced by VP in GIST882 and GIST48 cells, with a slight increase in IC50 values compared to the VP alone (Figure 3A).
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PMC11247842
However, a diverse array of post-GWAS methods and strategies can be employed to connect genomic variants to trait variation in cattle.
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PMC10213199
The DUSP1 encoded protein can dephosphorylate the MAP kinase MAPK1/ERK2, leading to its involvement in multiple cellular processes.
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PMC9429973
Pts who completed the fixed-dose period of ACTIVATE were eligible to continue in the LTE study, where all pts received mitapivat.
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PMC8633974
These results suggest that TatDE CRISPR is not more likely to affect host gene expression than the LTR-1/GagD system.
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PMC10222971
Regarding the cytotoxicity on non-tumoral cells, it showed 41.7% of viable cells.
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PMC9429973
In particular, as immune control of residual disease may be important for TFR, the concern is that the infection could induce loss of TFR.
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PMC11640247
Number of replicates, N ≥ 4.
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PMC11769516
Spontaneous Fusarium mycotoxicosis outbreaks have been reported in Europe, Asia, Africa, New Zealand and South America.
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PMC10996034
To investigate the role of DEGs on the basis of cell integral changes, the DEGs1 genes were subjected to GO and KEGG enrichment analysis.
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PMC9429973
The exact aspects of T-cell immunity underpinning association with asparaginase allergy has yet to be characterized.
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PMC11682224
The cells were cultivated at 37 °C in an incubator that was humidified and contained 94% N2, 5% CO2, and 1% O2.
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PMC9429973
At week 16, 4 patients (4/10, 40%) and at week 24, 5 patients, showed improvement in at least one of the 3 hematologic cell lines (partial response), respectively.
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PMC9964654
Particle size was measured three times by dynamic light scattering (DLS) at 25 °C with a 173° scattering angle and an optical arrangement known as non-invasive back scatter (NIBS).
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PMC8735881
Infection curves of the transduced CEMss-CCR5 cells.
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PMC10568263
To investigate the chemical states and constituent compositions of MoS2, MoO3, MnO2, and Au@MnO2, XPS spectra were utilized.
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PMC6771295
Error bars represent standard error of the mean of three independent experiments.
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PMC6889484
To determine whether resistant virus would emerge in CEMSS/D128K cells expressing lower amounts of A3G-D128K, single-cell clones were selected that expressed A3G-D128K-P2A at a 35% (low) or a 70% (medium) level compared to endogenous A3G expressed in CEM cells (Figure 5E).
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PMC9847912
The resultant data were plotted in Prism to determine 50% cytotoxic concentrations (CC50s) for each of the cell lines.
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PMC8753818
It seems that cell cycle arrest is the cause of decreasing cell proliferation which is due to the non-apoptotic roles of caspase-7.
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PMC11476666
In the MP subpopulation (Figure 6d–f), the decrease in SOX2 expression levels was even more significant (p < 0.05 and p < 0.01) for both stilbenes treatments.
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PMC11585254
We substituted Ser and Thr within each cluster to alanine and examined the ability of each phospho-site cluster variant to recruit β-arrestin1 or β-arrestin2 by BRET in response to CXCL13 stimulation in the β-arrestin1/2 DKO cell line.
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PMC11092418
To date temozolomide (TMZ) is the only drug that has gained the Food and Drug Administration (FDA) approval for treatment for patients with brain cancer, but it is accompanied by toxicity in some patients, highlighting the importance of discovering more specific therapeutic targets.
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PMC10470467
However, the prognosis of different types of cancer is affected differently by RIPK1 (27).
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