OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9429973	No differences in gender were found.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "differences", "in", "gender", "were", "found", "." ] } ]
PMC11527437	The vaccine elicited T cell responses against mKRAS in six of nine patients as determined by IFN-γ ELISPOT assay, and the inclusion of long mKRAS peptides appeared to enhance immunogenicity of the vaccine, likely through stimulation of CD4 T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11536589	A positive score of MGST1 and 4-HNE in tumor samples was quantified based on the percentage area and intensity of positive staining, and the numbers of Ki67 tumor cells in each section from 3 independent fields under 200× as reported (Huang et al. 1997; Qu et al. 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11025866	Cystine starvation induces CHAC1 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cystine", "starvation", "induces", "CHAC1", "expression", "." ] } ]
PMC11394227	Following the administration of tunicamycin, the apoptosis rate of CHO-PAb and CHO-PAb-QS cells was 24.7% and 12.9%, respectively, and the apoptosis rate of CHO-PAb-QS cells was 47.8% lower than that of CHO-PAb cells (Figure 6B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7154001	Antiproliferation (Leukemia and solid tumors models)Oridonin (ORI) (Diterpinoid of Isodon rubescens)Antiproliferation (Murine and human melanoma cells models)Quercetin (flavonoid)Antiproliferative by apoptotic induction (Colon carcinoma (CT-26), prostate adenocarcinoma (LNCaP), lymphoblastic leukemia MOLT-4 T-cells, and human lymphoid (Raji) cell models), Antitumor (breast (MCF-7) and colon carcinoma (CT-26) models)Trabectedin (ET-743: isolated compound from Ecteinascidia turbinata)Anticancer (Soft tissue sarcoma, ovarian and breast cancer)Yuanhuapine (Isolated from Daphne genkwa)Antiproliferative (Murine lymphocytic leukemia (P-338), Human lung carcinoma (A-549) cells models)Ziyuglycoside II (Sanguisorba officinalis L.)Antiproliferative (Gastric and breast carcinoma) Figure 1Flow diagram summarizing steps for exclusion and inclusion of the research articles included in the analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731161	All images were acquired using a fluorescence microscope (Olympus BX51, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "images", "were", "acquired", "using", "a", "fluorescence", ...
PMC9910796	In conclusion, pEP84R behaves as an integral membrane protein, in keeping with the membrane topology prediction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "pEP84R", "beh...
PMC6268318	It produced a significant hypoglycemic and antidiabetic activity comparable to the effect of a standard drug (0.6 mg/kg glibenclamide) (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Conducting a treatment-switching analyses was challenging due to immature OS data; however, this analysis supports the hypothesis that crossover to A bolstered ELEVATE-TN C+O OS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11354239	After 2 h of NK cell co-incubation with RTX-coated Raji, in the presence of anti-CD107a-FITC antibody, the cells were stained for 20 min with FVS510 and anti-CD56-PE/Vio770, as described above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We expect this study to identify new biomarkers to forecast disease progression and open an avenue for new combination therapies targeting the tumour microenvironment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11661024	All obtained sequences were searched using the Basic Local Alignment Tool (BLAST) program (https://blast.ncbi.nlm.nih.gov/Blast.cgi).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "obtained", "sequences", "were", ...
PMC10988555	The symbols ** and * represent p < 0.05 and p < 0.5, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "symbols", "", "", "and", "*", "represen...
PMC11656657	To further investigate the role of these two cytokines, we knocked-out in 143B cells either CSF3 (G-CSF) or IL-8 (CXCL8) gene using the CRISPR-Cas9 technology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11805741	Water loss fragments are usually formed during the fragmentation of protonated molecules, consequently [MH-H2O] + and [MH-2H2O] + fragments are significantly detected (Bijttebier et al. 2013).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9587298	The effect of MGO on HepG2 cells viability after 24 h exposure is shown in Fig. 6a3 (black bars) and is also dose-dependent, with an IC50 of 2.12 ± 0.05 mM. At higher concentrations, i.e. 4, 4.5 and 5 mM, high cytotoxic effect is observed, being cell viability only ∼ 1 % of control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8658661	There are several types of primary liver cancer: HCC (80–90% of cases), intrahepatic cholangiocarcinoma (ICCA, 10–15% of cases), HB and angiosarcoma (AS) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11795610	Keratin 10 mRNA. (	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Keratin", "10", "mRNA", ".", "(" ] } ]
PMC11787355	Created in BioRender.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Created", "in", "BioRender", "." ] } ]
PMC11676169	On the other hand, while BCAT1 is predominantly cytosolic, some protein pools have been localized in the cytoplasmic membrane and the nucleus .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10818573	When the reaction time was 15 min, the bands were sufficiently clear, and at 20 min, the bands were not notably different from those obtained in the 15 min reaction (Figure 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The single patient with HGT and D0 CRP <100 interestingly was a non-responder.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "single", "patient", "with", "HGT", "and", "D0", "CRP", ...
PMC11138140	These include the time it takes to reacclimatize cultures back to 37 °C to resolve condensation on the culture plate imaging surface, which interferes with image acquisition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240448	The highly ranked components constitute the core network that controls the changes in the cell-wide network and the phenotypes scored by the DPDs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC5963610	Available reports likely use the (more common) NAcGM3 ganglioside.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Available", "reports", "likely", "use", "the", "(", "more", "common", ")", "NAcGM3", ...
PMC11583010	Hence, these constructs confirmed that selectivity toward tumor cells over keratinocytes was due to a better binding and internalization in tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence",...
PMC10047551	DNA (cytosine-5)-methyltransferases (DNMTs) establish (DNMT1) and maintain (DNMT3A/3B) DNA methylation, whereas ten-eleven translocation methylcytosine dioxygenase (TET) proteins, together with DNA repair pathways, inhibit DNA methylation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8526701	The silencing of BRD9 was efficient in the siRNA-treated groups (Fig. 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "silencing", "of", "BRD9", "was", "efficient", "in", "the"...
PMC11741577	The effect of HMC-1 CM obtained with or without TLR agonist stimulation on HaCaT cell migration was assessed using wound closure measurements (n = 10).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10366908	Most of the mAbs recognized the conformational epitopes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "of", "the", "mAbs", "recognized", "the", "conformational", "epitopes", "." ] } ]
PMC9429973	Consistent with prior studies, no level A therapy sensitizing variants were identified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consistent", "with", "prior", "studies", ",", "no", "level", "A", "th...
PMC9429973	Seventeen patients of the cohort underwent a 2 allo-SCT, 14 in CR (13 after intensive salvage, 1 after non intensive salvage) and 6 with active disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10734950	In contrast, there were minor phosphorylation effects on MAP Kinase array proteins after F8-treatment, with values for ERK 1/2 (1.16), MSK2 (1.03), CREB (0.83), HSP 27 (0.94), JNK (1.04), MEK (0.94), MMK3 (0.82), MMK6 (0.94), P38 (1.10), P53 (0.73), and RSK 1 (1.18).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10094992	Consistent with reduced IL-8 release (Figure 5G), we observed a reduction in the recruitment of neutrophils in NR6-treated H2596 MCSs, compared with controls (Figure 5H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...
PMC11672881	Moreover, the World Health Organization has encouraged developing countries to incorporate traditional medicinal plants into their primary healthcare programs .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", ...
PMC11476264	FBXO11 overexpression significantly increased ZEB1 ubiquitination, particularly K48-linked ubiquitination (Figure 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FBXO11", "overexpression", "significantly", "increased", "ZEB1", "ubiquitina...
PMC11307990	Among them, renal clear cell carcinoma accounts for approximately 70 to 75% of all renal malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "them", ",", "renal", "clear",...
PMC9611901	As HepG2 cells were successfully used in several previous studies which investigated toxic potential of various dyes and agents common in the textile and leather industry , it seems reasonable to select them for this experiment.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6442998	Thus, we assessed in GIST882 and GIST48 cells the expression of the two main differentiation markers: KIT, expressed in mesenchymal precursors and in ICC, and αSMA, an early marker of smooth muscle cells .	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10048572	Cell lines were obtained from ATCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "lines", "were", "obtained", "from", "ATCC", "." ] } ]
PMC10734950	A cell cycle analysis measured cellular DNA content in CCRF-CEM cells upon treatment with F8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "cell", "cycle", "analysis", "measured", "cellular",...
PMC9275501	Finally, it showed good therapeutic effect in clinical application.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "it", "showed", "good", "therapeutic", "effect", "in", "clinical", "application",...
PMC11730311	Results from Schild regression analyses.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "from", "Schild", "regression", "analyses", "." ] } ]
PMC9812014	Celgosivir repressed BVDV growth at an IC50 of 16 µM and 47 µM respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Celgosivir", "repressed", "BVDV", "growth", "at", "an", "IC50", ...
PMC10978090	Routine coagulation tests and measurement of argatroban anti-IIa activity (Hemoclot Thrombin Inhibitors, Hyphen Biomed) were performed on an ACL TOP 700 analyzer (Werfen, Spain).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770199	We next investigated whether p14-expressing cells could fuse with p14-negative cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "next", "investigated", "whether", "p14-expressing", "cells", "could", "fuse", "with",...
PMC8584666	Next, in order to confirm GPI-80 localization at the tip of the pseudopod and filopodium, F-actin was stained with phalloidin after cell membrane permeabilization using 0.5% Triton-X 100.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8557138	Interestingly, recent developments in genomics have revealed significant endothelial heterogeneity and intra-individual variations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "recent", "developments", "in", "genomics", "have...
PMC11640555	After this period, cells were washed with PBS and then fixed with 4% paraformaldehyde (PFA) for 30 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "thi...
PMC11715644	We found that wild-type cells displayed the highest difference between confined and unconfined cell migration speed, which further increased when monolayers attempt to enter narrow channels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Pts who received DL3 or DL4, had an ORR 100% and CR rate of 89%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pts", "who", "received", "DL3", "or", ...
PMC9429973	AEs of special interest were CRS (24% grade [G] 1, 18% G2, 3% G3; resolved) and ICANS (3% G2; resolved); tumor lysis syndrome was observed in 1 pt (3% G3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: To try to respond to this need in the real practice of MM treatment, we share for the first time a new observational study called Carinae, that describes the clinical practice in TNE-NDMM in Spain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: Even though vaccination is encouraged for these patients, data on the efficacy of anti-Sars-CoV-2 vaccines in this specific population remain limited, due to its exclusion from clinical trials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11473843	All cell lines were DNA fingerprinted for provenance, screened for mycoplasma and cultured in an incubator at 37 °C and 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11705630	Moreover, depletion of GLDC in ACHN cells indeed attenuated the number of secondary tumor spheres and overexpression GLDC in A498 cells stimulated the number of secondary tumor spheres (Fig. S1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "...
PMC9429973	MB-CART2019.1 is currently challenging conventional immune-chemotherapy in a randomized Phase II trial for elderly, non-transplant eligible pts with first progression or relapse of aggressive B-NHL (NCT04844866).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The 10 most frequently mutated CDGs were SOCS1 (86%), B2M (67%), ITPKB (64%), ACTB (58%), STAT6 (58%), IGLL5 (56%), TNFAIP3 (53%), NFKBIE (49%), GNA13 (47%), and ZNF217 (36%), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10976516	Nevertheless, their limited capacity to reach metastatic tumors in these experimental settings did not diminish their use as OV carriers to target primary lung tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11342785	The circuit’s bundling dynamics were quantified as in (D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "circuit", "’s", "bundling", "dynamics", "were", "quantified", "as", "in",...
PMC4270159	Transfer and blocking: a. Transfer protein on the gel to a nitrocellulose membrane for 1 hr at 12 V using a semi-dry transfer apparatus, 1× transfer buffer, and blotting sheets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11782780	To further validate the impact of EBF3 on the glycolysis capacity of BC cells, we set up sh-NC + PBS, sh-EBF3 + PBS, sh-EBF3 + glycolysis inhibitor (2-DG or 3-BP) treatment groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754784	The logic flowchart and truth table of DNP2 is shown in Fig. 3b and the reaction pathways are shown in Fig. 3c.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "logic...
PMC11295144	No change was observed with the application of α2 (median = 6.03%; IQR = 4.04 – 7.58%; n = 20 cells; from N = 2 independent experiments) or γ2 (median = 6.22%; IQR = 4.05 – 7.33%; n = 20 cells; from N = 2 independent experiments) ECDs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794847	In addition, molecular docking also revealed the interaction between HVEM and FOXA2 (Fig. 8D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "molecular", "docking", ...
PMC8316344	Data were analyzed by one-way ANOVA and expressed as mean ± SD from three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "analyzed", "by", "one-way", "ANOVA", ...
PMC10631132	Scale bars: A, C, E, G = 100 µm, B, D, F, H = 25 µm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11473843	Cells were lysed in RIPA buffer (50 mM Tris-HCl pH 8.0, 150 mM NaCl, 1.0% NP-40, 0.5% sodium deoxycholate, 0.1% SDS) or NP40 buffer (50 mM Tris-HCl pH 8.0, 150 mM NaCl, 1% NP-40) with complete EDTA-free protease inhibitors (Roche) and 1 mM PMSF.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11623887	NS1 regulates DNA replication and transcription, induces IL-6 and proinflammatory cytokines production and induce damage and apoptosis in the infected cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NS1", "regul...
PMC9250505	Indeed, clinical responses of Olaparib and PI3K/AKT/mTOR inhibitor combinations in BRCA wild-type or platinum-resistant EOC were superior to monotherapies (summarized in Supplementary Table 7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8358006	We found genes with the top 5% grand H3K27me3 domain have significant greater missense Z score (Fig. 1f, P = 3.70 × 10, Wilcoxon rank sum test) and lower dN/dS (Fig. 1g, P = 1.53 × 10, Wilcoxon rank sum test) than other genes without grand H3K27me3 domains, which implied that genes marked by grand H3K27me3 domains are more constrained and intolerance to the class of variation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11155445	Above mentioned compounds showed antiviral activity, because they contained fluorine atoms and thiazole structures (Fig. 47).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Above", "mentioned", "compounds", ...
PMC2944824	Indeed, the percent increase in viability afforded by expressing Hr was significantly greater in wild type MEF compared to p53 knockout MEF after treatment with staurosporine and tunicamycin (figure 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "...
PMC6379402	b The same as a, but averaged over all tissues and according to each of reactome pathway (RP), KEGG pathway (KP), and gene ontology biological process (GO-BP) annotations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9592219	The overexpression of TOP2A results in accelerated tumor progression and a poor prognosis in lung adenocarcinoma .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "overexpression", "of", "TOP2A", "results", "in"...
PMC11021472	Both vectors contain a GFP reporter, allowing sorting of GFP cells using a MoFlo sorter (BD Biosciences, Franklin Lakes, NJ, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8193813	In anticipation of temperatures as low as 0 °C at the Midland site and to avoid daily temperature fluctuations, insulation was added to the Kolibri frame, and the sampled gases were preheated prior to the sensor with the use of a heating element and micro-fan inside the Kolibri.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11725127	The observed rate constant for binding (kobs) of biotin–GA to USP2 was determined to be 0.023 min (D). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10772747	Network pharmacology analysis reveals that EBE influences 42 genes involved in breast cancer, including 23 important target genes implicated in the pathophysiology of breast cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7334607	With this understanding, our experiment would, of course, benefit from even more experimental evolutionary replicates to confirm the repeatability of some observations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8922418	Among them, ZFN and TALEN are two special nucleases that recognize genome editing sites through protein-DNA interactions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "them", ",", "ZFN", "and", ...
PMC10706275	Through 5′ and 3′ junction PCR, we identified four positive monoclonal strains (K1-EGFP-8, K1-EGFP-15, K1-EGFP-21, K1-EGFP-24) out of the 32 tested.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10656496	All drug screens were completed in 2D using cell monolayers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "drug", "screens", "were", "completed", "in", "2D", "using", "cell", "monolayers", "...
PMC5854676	The model shown in Eq. (3) is fit using regression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "model", "shown", "in", "Eq.", "(", "3", ")", "is", "fit", "us...
PMC3681794	The pattern of hypoxia-induced resistance to etoposide and doxorubicin, with 791T cells showing the least and U2OS cells the greatest, reflected the relative sensitivity of the three osteosarcoma cell lines to these agents in normoxia; the IC50 for etoposide in 791T cells in normoxia was 12.6 µM as compared to 0.8 µM in U2OS cells, whilst for doxorubicin the values were 0.7 µM and <0.14 µM. However this was not the case with cisplatin to which all three cell lines were similarly sensitive in normoxia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O"...
PMC11291490	The visualization of E protein expression was achieved using DAB (Solarbio, China), and the images were captured using microscopy (Olympus, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7215832	Briefly, cells were washed and treated with TRIzol (Life Technologies, Bleiswijk, the Netherlands).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "cells", "were", "washe...
PMC11803918	Exosomes are small extracellular vesicles (20–200 nm) originating from endosomes that shuttle lipids, proteins, and nucleic acids between different cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11612794	This study did not generate new unique reagents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "did", "not", "generate", "new", "unique", "reagents", "." ] } ]
PMC11519077	In addition, although the expression level of NOD1 in AD-MSC-, AD-CM-, BM-MSC-, and BM-CM-treated groups was significantly lower than the IL-1β-induced Caco-2 group, it was still significantly higher than the control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC11609529	These findings confirms that YM-positive cancer cells are vulnerable to interventions that target the YAP1/TEAD axis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "confirms", "that", "YM-positive", ...
PMC5810978	The cells were rinsed and maintained with DMEM/F12 1:1 (Invitrogen) supplemented with the antibiotics after inoculation with HuNoVs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", ...
PMC11599565	Thirty micrograms of total protein were resolved by SDS-PAGE in a 4–12% gradient gel (Bio-Rad Laboratories, CA, USA) using Tris–glycine (0.025 M Tris–HCl, 0.192 M glycine pH 8.5) buffer, and transferred to 0.2 mm nitrocellulose membrane (Pierce Protein; Thermo Scientific, Inc.).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092418	EGFR: epidermal growth factor receptor; HER: human epidermal growth factor receptor; c-MET: mesenchymal-epithelial transition factor; ALK7: anaplastic lymphoma kinase 7: CD44: cluster differentiation 44.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11743316	Tumors with an identical clinical diagnosis may have mitochondrial metabolic heterogeneity, employing fatty acids or glutamine as additional oxidizable sources.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumors", "with", ...
PMC11588085	XIST KD leads to M-CSC enrichment in ovarian cancer cell line. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "O" ], "tokens": [ "XIST", "KD", "leads", "to", "M-CSC", "enrichment", "in",...
PMC11434983	Both complexes induced G0/G1 cell cycle arrest, with Complex 2 additionally promoting apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "complexes", "induced", "G0/G1", "cell", "cycle", "arrest", ...
PMC7724160	This might be especially true given that our cell line of interest had decreasing antibody production over time .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "might", "be", "especially", "t...
PMC11621493	We also determined hydrolase activity against radiolabeled DAG or TAG emulsified in phospholipid micelles using established protocols (13).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "determined", ...

PMC9429973

No differences in gender were found.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "differences", "in", "gender", "were", "found", "." ] } ]

PMC11527437

The vaccine elicited T cell responses against mKRAS in six of nine patients as determined by IFN-γ ELISPOT assay, and the inclusion of long mKRAS peptides appeared to enhance immunogenicity of the vaccine, likely through stimulation of CD4 T cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11536589

A positive score of MGST1 and 4-HNE in tumor samples was quantified based on the percentage area and intensity of positive staining, and the numbers of Ki67 tumor cells in each section from 3 independent fields under 200× as reported (Huang et al. 1997; Qu et al. 2018).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11025866

Cystine starvation induces CHAC1 expression.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cystine", "starvation", "induces", "CHAC1", "expression", "." ] } ]

PMC11394227

Following the administration of tunicamycin, the apoptosis rate of CHO-PAb and CHO-PAb-QS cells was 24.7% and 12.9%, respectively, and the apoptosis rate of CHO-PAb-QS cells was 47.8% lower than that of CHO-PAb cells (Figure 6B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7154001

Antiproliferation (Leukemia and solid tumors models)Oridonin (ORI) (Diterpinoid of Isodon rubescens)Antiproliferation (Murine and human melanoma cells models)Quercetin (flavonoid)Antiproliferative by apoptotic induction (Colon carcinoma (CT-26), prostate adenocarcinoma (LNCaP), lymphoblastic leukemia MOLT-4 T-cells, and human lymphoid (Raji) cell models), Antitumor (breast (MCF-7) and colon carcinoma (CT-26) models)Trabectedin (ET-743: isolated compound from Ecteinascidia turbinata)Anticancer (Soft tissue sarcoma, ovarian and breast cancer)Yuanhuapine (Isolated from Daphne genkwa)Antiproliferative (Murine lymphocytic leukemia (P-338), Human lung carcinoma (A-549) cells models)Ziyuglycoside II (Sanguisorba officinalis L.)Antiproliferative (Gastric and breast carcinoma) Figure 1Flow diagram summarizing steps for exclusion and inclusion of the research articles included in the analysis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11731161

All images were acquired using a fluorescence microscope (Olympus BX51, Japan).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "images", "were", "acquired", "using", "a", "fluorescence", ...

PMC9910796

In conclusion, pEP84R behaves as an integral membrane protein, in keeping with the membrane topology prediction.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "pEP84R", "beh...

PMC6268318

It produced a significant hypoglycemic and antidiabetic activity comparable to the effect of a standard drug (0.6 mg/kg glibenclamide) (Table 1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9429973

Conducting a treatment-switching analyses was challenging due to immature OS data; however, this analysis supports the hypothesis that crossover to A bolstered ELEVATE-TN C+O OS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11354239

After 2 h of NK cell co-incubation with RTX-coated Raji, in the presence of anti-CD107a-FITC antibody, the cells were stained for 20 min with FVS510 and anti-CD56-PE/Vio770, as described above.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

We expect this study to identify new biomarkers to forecast disease progression and open an avenue for new combination therapies targeting the tumour microenvironment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11661024

All obtained sequences were searched using the Basic Local Alignment Tool (BLAST) program (https://blast.ncbi.nlm.nih.gov/Blast.cgi).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "obtained", "sequences", "were", ...

PMC10988555

The symbols ** and * represent p < 0.05 and p < 0.5, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "symbols", "*", "*", "and", "*", "represen...

PMC11656657

To further investigate the role of these two cytokines, we knocked-out in 143B cells either CSF3 (G-CSF) or IL-8 (CXCL8) gene using the CRISPR-Cas9 technology.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11805741

Water loss fragments are usually formed during the fragmentation of protonated molecules, consequently [MH-H2O] + and [MH-2H2O] + fragments are significantly detected (Bijttebier et al. 2013).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9587298

The effect of MGO on HepG2 cells viability after 24 h exposure is shown in Fig. 6a3 (black bars) and is also dose-dependent, with an IC50 of 2.12 ± 0.05 mM. At higher concentrations, i.e. 4, 4.5 and 5 mM, high cytotoxic effect is observed, being cell viability only ∼ 1 % of control.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8658661

There are several types of primary liver cancer: HCC (80–90% of cases), intrahepatic cholangiocarcinoma (ICCA, 10–15% of cases), HB and angiosarcoma (AS) .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11795610

Keratin 10 mRNA. (

[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Keratin", "10", "mRNA", ".", "(" ] } ]

PMC11787355

Created in BioRender.

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Created", "in", "BioRender", "." ] } ]

PMC11676169

On the other hand, while BCAT1 is predominantly cytosolic, some protein pools have been localized in the cytoplasmic membrane and the nucleus .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC10818573

When the reaction time was 15 min, the bands were sufficiently clear, and at 20 min, the bands were not notably different from those obtained in the 15 min reaction (Figure 4A).

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PMC9429973

The single patient with HGT and D0 CRP <100 interestingly was a non-responder.

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PMC11138140

These include the time it takes to reacclimatize cultures back to 37 °C to resolve condensation on the culture plate imaging surface, which interferes with image acquisition.

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PMC11240448

The highly ranked components constitute the core network that controls the changes in the cell-wide network and the phenotypes scored by the DPDs.

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PMC5963610

Available reports likely use the (more common) NAcGM3 ganglioside.

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PMC11583010

Hence, these constructs confirmed that selectivity toward tumor cells over keratinocytes was due to a better binding and internalization in tumor cells.

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PMC10047551

DNA (cytosine-5)-methyltransferases (DNMTs) establish (DNMT1) and maintain (DNMT3A/3B) DNA methylation, whereas ten-eleven translocation methylcytosine dioxygenase (TET) proteins, together with DNA repair pathways, inhibit DNA methylation .

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PMC8526701

The silencing of BRD9 was efficient in the siRNA-treated groups (Fig. 2A).

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PMC11741577

The effect of HMC-1 CM obtained with or without TLR agonist stimulation on HaCaT cell migration was assessed using wound closure measurements (n = 10).

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PMC10366908

Most of the mAbs recognized the conformational epitopes.

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PMC9429973

Consistent with prior studies, no level A therapy sensitizing variants were identified.

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PMC9429973

Seventeen patients of the cohort underwent a 2 allo-SCT, 14 in CR (13 after intensive salvage, 1 after non intensive salvage) and 6 with active disease.

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PMC10734950

In contrast, there were minor phosphorylation effects on MAP Kinase array proteins after F8-treatment, with values for ERK 1/2 (1.16), MSK2 (1.03), CREB (0.83), HSP 27 (0.94), JNK (1.04), MEK (0.94), MMK3 (0.82), MMK6 (0.94), P38 (1.10), P53 (0.73), and RSK 1 (1.18).

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PMC10094992

Consistent with reduced IL-8 release (Figure 5G), we observed a reduction in the recruitment of neutrophils in NR6-treated H2596 MCSs, compared with controls (Figure 5H).

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PMC11672881

Moreover, the World Health Organization has encouraged developing countries to incorporate traditional medicinal plants into their primary healthcare programs .

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PMC11476264

FBXO11 overexpression significantly increased ZEB1 ubiquitination, particularly K48-linked ubiquitination (Figure 3B).

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PMC11307990

Among them, renal clear cell carcinoma accounts for approximately 70 to 75% of all renal malignancies.

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PMC9611901

As HepG2 cells were successfully used in several previous studies which investigated toxic potential of various dyes and agents common in the textile and leather industry , it seems reasonable to select them for this experiment.

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PMC6442998

Thus, we assessed in GIST882 and GIST48 cells the expression of the two main differentiation markers: KIT, expressed in mesenchymal precursors and in ICC, and αSMA, an early marker of smooth muscle cells .

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PMC10048572

Cell lines were obtained from ATCC.

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PMC10734950

A cell cycle analysis measured cellular DNA content in CCRF-CEM cells upon treatment with F8.

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PMC9275501

Finally, it showed good therapeutic effect in clinical application.

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PMC11730311

Results from Schild regression analyses.

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PMC9812014

Celgosivir repressed BVDV growth at an IC50 of 16 µM and 47 µM respectively.

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PMC10978090

Routine coagulation tests and measurement of argatroban anti-IIa activity (Hemoclot Thrombin Inhibitors, Hyphen Biomed) were performed on an ACL TOP 700 analyzer (Werfen, Spain).

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PMC11770199

We next investigated whether p14-expressing cells could fuse with p14-negative cells.

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PMC8584666

Next, in order to confirm GPI-80 localization at the tip of the pseudopod and filopodium, F-actin was stained with phalloidin after cell membrane permeabilization using 0.5% Triton-X 100.

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PMC8557138

Interestingly, recent developments in genomics have revealed significant endothelial heterogeneity and intra-individual variations.

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PMC11640555

After this period, cells were washed with PBS and then fixed with 4% paraformaldehyde (PFA) for 30 min.

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PMC11715644

We found that wild-type cells displayed the highest difference between confined and unconfined cell migration speed, which further increased when monolayers attempt to enter narrow channels.

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PMC9429973

Pts who received DL3 or DL4, had an ORR 100% and CR rate of 89%.

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PMC9429973

AEs of special interest were CRS (24% grade [G] 1, 18% G2, 3% G3; resolved) and ICANS (3% G2; resolved); tumor lysis syndrome was observed in 1 pt (3% G3).

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PMC9429973

Aims: To try to respond to this need in the real practice of MM treatment, we share for the first time a new observational study called Carinae, that describes the clinical practice in TNE-NDMM in Spain.

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PMC9429973

Aims: Even though vaccination is encouraged for these patients, data on the efficacy of anti-Sars-CoV-2 vaccines in this specific population remain limited, due to its exclusion from clinical trials.

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PMC11473843

All cell lines were DNA fingerprinted for provenance, screened for mycoplasma and cultured in an incubator at 37 °C and 5% CO2.

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PMC11705630

Moreover, depletion of GLDC in ACHN cells indeed attenuated the number of secondary tumor spheres and overexpression GLDC in A498 cells stimulated the number of secondary tumor spheres (Fig. S1A).

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PMC9429973

MB-CART2019.1 is currently challenging conventional immune-chemotherapy in a randomized Phase II trial for elderly, non-transplant eligible pts with first progression or relapse of aggressive B-NHL (NCT04844866).

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PMC9429973

The 10 most frequently mutated CDGs were SOCS1 (86%), B2M (67%), ITPKB (64%), ACTB (58%), STAT6 (58%), IGLL5 (56%), TNFAIP3 (53%), NFKBIE (49%), GNA13 (47%), and ZNF217 (36%), respectively.

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PMC10976516

Nevertheless, their limited capacity to reach metastatic tumors in these experimental settings did not diminish their use as OV carriers to target primary lung tumors.

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PMC11342785

The circuit’s bundling dynamics were quantified as in (D).

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PMC4270159

Transfer and blocking: a. Transfer protein on the gel to a nitrocellulose membrane for 1 hr at 12 V using a semi-dry transfer apparatus, 1× transfer buffer, and blotting sheets.

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PMC11782780

To further validate the impact of EBF3 on the glycolysis capacity of BC cells, we set up sh-NC + PBS, sh-EBF3 + PBS, sh-EBF3 + glycolysis inhibitor (2-DG or 3-BP) treatment groups.

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PMC11754784

The logic flowchart and truth table of DNP2 is shown in Fig. 3b and the reaction pathways are shown in Fig. 3c.

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PMC11295144

No change was observed with the application of α2 (median = 6.03%; IQR = 4.04 – 7.58%; n = 20 cells; from N = 2 independent experiments) or γ2 (median = 6.22%; IQR = 4.05 – 7.33%; n = 20 cells; from N = 2 independent experiments) ECDs.

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PMC11794847

In addition, molecular docking also revealed the interaction between HVEM and FOXA2 (Fig. 8D).

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PMC8316344

Data were analyzed by one-way ANOVA and expressed as mean ± SD from three independent experiments.

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PMC10631132

Scale bars: A, C, E, G = 100 µm, B, D, F, H = 25 µm.

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PMC11473843

Cells were lysed in RIPA buffer (50 mM Tris-HCl pH 8.0, 150 mM NaCl, 1.0% NP-40, 0.5% sodium deoxycholate, 0.1% SDS) or NP40 buffer (50 mM Tris-HCl pH 8.0, 150 mM NaCl, 1% NP-40) with complete EDTA-free protease inhibitors (Roche) and 1 mM PMSF.

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PMC11623887

NS1 regulates DNA replication and transcription, induces IL-6 and proinflammatory cytokines production and induce damage and apoptosis in the infected cells.

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PMC9250505

Indeed, clinical responses of Olaparib and PI3K/AKT/mTOR inhibitor combinations in BRCA wild-type or platinum-resistant EOC were superior to monotherapies (summarized in Supplementary Table 7).

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PMC8358006

We found genes with the top 5% grand H3K27me3 domain have significant greater missense Z score (Fig. 1f, P = 3.70 × 10, Wilcoxon rank sum test) and lower dN/dS (Fig. 1g, P = 1.53 × 10, Wilcoxon rank sum test) than other genes without grand H3K27me3 domains, which implied that genes marked by grand H3K27me3 domains are more constrained and intolerance to the class of variation.

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PMC11155445

Above mentioned compounds showed antiviral activity, because they contained fluorine atoms and thiazole structures (Fig. 47).

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PMC2944824

Indeed, the percent increase in viability afforded by expressing Hr was significantly greater in wild type MEF compared to p53 knockout MEF after treatment with staurosporine and tunicamycin (figure 5).

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PMC6379402

b The same as a, but averaged over all tissues and according to each of reactome pathway (RP), KEGG pathway (KP), and gene ontology biological process (GO-BP) annotations.

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PMC9592219

The overexpression of TOP2A results in accelerated tumor progression and a poor prognosis in lung adenocarcinoma .

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PMC11021472

Both vectors contain a GFP reporter, allowing sorting of GFP cells using a MoFlo sorter (BD Biosciences, Franklin Lakes, NJ, USA).

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PMC8193813

In anticipation of temperatures as low as 0 °C at the Midland site and to avoid daily temperature fluctuations, insulation was added to the Kolibri frame, and the sampled gases were preheated prior to the sensor with the use of a heating element and micro-fan inside the Kolibri.

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PMC11725127

The observed rate constant for binding (kobs) of biotin–GA to USP2 was determined to be 0.023 min (D). (

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PMC10772747

Network pharmacology analysis reveals that EBE influences 42 genes involved in breast cancer, including 23 important target genes implicated in the pathophysiology of breast cancer.

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PMC7334607

With this understanding, our experiment would, of course, benefit from even more experimental evolutionary replicates to confirm the repeatability of some observations.

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PMC8922418

Among them, ZFN and TALEN are two special nucleases that recognize genome editing sites through protein-DNA interactions.

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PMC10706275

Through 5′ and 3′ junction PCR, we identified four positive monoclonal strains (K1-EGFP-8, K1-EGFP-15, K1-EGFP-21, K1-EGFP-24) out of the 32 tested.

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PMC10656496

All drug screens were completed in 2D using cell monolayers.

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PMC5854676

The model shown in Eq. (3) is fit using regression.

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PMC3681794

The pattern of hypoxia-induced resistance to etoposide and doxorubicin, with 791T cells showing the least and U2OS cells the greatest, reflected the relative sensitivity of the three osteosarcoma cell lines to these agents in normoxia; the IC50 for etoposide in 791T cells in normoxia was 12.6 µM as compared to 0.8 µM in U2OS cells, whilst for doxorubicin the values were 0.7 µM and <0.14 µM. However this was not the case with cisplatin to which all three cell lines were similarly sensitive in normoxia.

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PMC11291490

The visualization of E protein expression was achieved using DAB (Solarbio, China), and the images were captured using microscopy (Olympus, Japan).

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PMC7215832

Briefly, cells were washed and treated with TRIzol (Life Technologies, Bleiswijk, the Netherlands).

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PMC11803918

Exosomes are small extracellular vesicles (20–200 nm) originating from endosomes that shuttle lipids, proteins, and nucleic acids between different cells.

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PMC11612794

This study did not generate new unique reagents.

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PMC11519077

In addition, although the expression level of NOD1 in AD-MSC-, AD-CM-, BM-MSC-, and BM-CM-treated groups was significantly lower than the IL-1β-induced Caco-2 group, it was still significantly higher than the control group.

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PMC11609529

These findings confirms that YM-positive cancer cells are vulnerable to interventions that target the YAP1/TEAD axis.

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PMC5810978

The cells were rinsed and maintained with DMEM/F12 1:1 (Invitrogen) supplemented with the antibiotics after inoculation with HuNoVs.

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PMC11599565

Thirty micrograms of total protein were resolved by SDS-PAGE in a 4–12% gradient gel (Bio-Rad Laboratories, CA, USA) using Tris–glycine (0.025 M Tris–HCl, 0.192 M glycine pH 8.5) buffer, and transferred to 0.2 mm nitrocellulose membrane (Pierce Protein; Thermo Scientific, Inc.).

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PMC11092418

EGFR: epidermal growth factor receptor; HER: human epidermal growth factor receptor; c-MET: mesenchymal-epithelial transition factor; ALK7: anaplastic lymphoma kinase 7: CD44: cluster differentiation 44.

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PMC11743316

Tumors with an identical clinical diagnosis may have mitochondrial metabolic heterogeneity, employing fatty acids or glutamine as additional oxidizable sources.

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PMC11588085

XIST KD leads to M-CSC enrichment in ovarian cancer cell line. (

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PMC11434983

Both complexes induced G0/G1 cell cycle arrest, with Complex 2 additionally promoting apoptosis.

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PMC7724160

This might be especially true given that our cell line of interest had decreasing antibody production over time .

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PMC11621493

We also determined hydrolase activity against radiolabeled DAG or TAG emulsified in phospholipid micelles using established protocols (13).

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