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OTAR3088
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BioData-CellLine_annotated

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PMC9812014
Aranotin was found to be effective against CV A21 in the In vivo mice model, with an ED50 of 0.125 mg/kg i.p. .
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PMC8973085
Yellow solid [A] (89%); [B] (72%); mp: 190–194 °C.
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PMC11765678
Human ovarian OVCAR-8 and NCI/ADR-RES cell lines were obtained from the NCI-Frederick Cancer Center (Frederick, MD, USA), and human MCF-7 breast tumor cells were obtained from ATCC (Manassas, VA, USA).
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PMC11650848
In addition, we show for the first time a potential interaction between these mQTLs and continued FA supplementation during pregnancy and that this tracks with positive cognitive outcomes in early life.
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PMC11560255
We examined the ethanolic bark extract of PMBE to determine its capacity to inhibit the cervical cancer HeLa cell’s growth or viability to verify the antiproliferative effect of the plant.
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PMC6461034
‒Node coordinates are calculated using a Fruchterman–Reingold layout algorithm for force‐directed graph drawing with empirically chosen parameter settings (for N nodes: niter = 100N, area = N, repulse.rad = N, and ncell = N).‒Nodes are depicted as a hexagon (observed kinases, identified through one or more phosphopeptides), a pentagon (inferred kinases lacking direct observation, but linked to phosphorylation of one or more observed phosphopeptides), or as a circle (non‐kinase substrates).‒Kinase node colors correlate with INKA scores in a white to red gradient, and kinases with at least one phosphorylated activation loop phosphosite are indicated by a thicker node border.‒Edge widths correlate with the associated substrate site “phosphosignal”, and edge colors indicate the analysis on which the kinase–substrate relationship was based (coral: PSP, cornflowerblue: NWK, forestgreen: both).
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PMC10530622
Strategies to modulate the gut microbiota have not been sufficiently explored in kidney disease, but could be a mitigating approach for this situation, with a possible impact on lithiasis risk.
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PMC11656048
Similarly, our results show that shikonin can increase the levels of ferrous ions, ROS, lipid peroxidation, and MDA in OS cells.
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PMC11201245
Both the target DNA in the prepared cells and the DNA of the OC-FISH test were co-denatured after covering with 11 µL OC-FISH test/slide half at 75 °C.
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PMC11794568
EDU cell proliferation assay was used to assess the proliferative capacity after the addition of rotenone to CRIP1-silenced cutaneous melanoma cells (scale bar is 50 μm). (
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PMC9622879
Figure 1Structure of community energy management.
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PMC11545868
Lastly, in the study of Zhang, B., et al., glycitein also increased the membrane permeability of human breast cancer SKBR-3 cells, suggesting a possible anticancer effect by damaging the cell membrane .
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PMC11779960
Notably, at a protein level, in our immunohistochemical studies, and more recent flow-cytometric studies, most cases predominantly and homogeneously express one or the other TRBC isoform.
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PMC11790599
Untreated and TSL-treated cells were incubated with 1.25 mg/mL of lucifer yellow in HBSS in a 37°C, 5% CO2 incubator for 30 min.
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PMC11406030
Cells grown in 8-well chamber slides were fixed and stained with DAPI (A), LMTK3 antibody (Invitrogen 1:200) (B), and LMTK3 biotin-labeled peptide 1 (100 μg/mL) (C); (A) and (B) were merged to show LMTK3 cytoplasmic localization (D).
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PMC11767725
The exaggerated inflammatory response in SD involves the upregulation of cytokines like TNF-α, IL-6, and IL-1β, alongside activation of NF-κB and MAPK pathways.
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PMC11583010
There are few data reporting entry and diffusion of ADCs into solid tumors.
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PMC11782780
Pearson correlation analysis was performed, and abnormally distributed data were analyzed by the Wilcoxon test.
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PMC11705862
Statistics (in E, G, H, J, L, and N): two-tailed student T-test.
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PMC11496491
Through the corresponding software transformation of sequencing, we can obtain the data off the machine.
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PMC8956657
Pymol software was used to generate images.
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PMC11486946
Subsequently, the compounds were washed out with HBSS, and the cells were fixed with 4% PFA for 30 min at 4 °C and solubilized with 0.5% Triton X100 in HBSS at room temperature, followed by washing with HBSS three times and left at 4 °C overnight.
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PMC11575040
Kaplan–Meier survival analysis revealed that the high LINC00094 expression group exhibited shorter OS than did the low LINC00094 expression group, albeit without statistical significance (n = 103, log-rank test, p = 0.1; Fig. 1G).
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PMC8750422
Even though advanced anticancer drugs are available, prognosis of patients with lung cancer is dismal and there is an urgent need to explore novel oncogenic mechanisms to overcome these therapeutic limitations.
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PMC11650848
There were also differences in neural activity during language tasks, as measured by MEG.
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PMC11412721
For all experiments, mice housing and treatment were conducted according to the Institutional Animal Care and Use Committee of the Institut Curie (approved project #03769.02).
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PMC11314247
These results suggest that HO-AAVPA’s possible mechanism of action in the three cell lines is by decreasing GPER expression, particularly in the MDA-MB-231 line, which represents an interesting type of cancer, since it is defined as TNBC, and for which treatment is not yet well defined.
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PMC11703992
Based on the causal effect of DDIT4 and ARHGAP15 to GCA in CD4+ Memory T cells, we identified DEGs between DDIT4 ± and ARHGAP15 ± groups, and performed enrichment analysis using Metascape for each group (Fig. S5D).
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PMC9596868
E–H) Percentage cell viability of PA-1, A2780, OVCAR3 and OSE cells, respectively, after treatment with MST-312 at various concentrations.
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PMC10907726
First, OS cells viability was determined by CCK8 assay.
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PMC10698968
All cells were cultured in a monolayer at 37 °C and 5% CO2 in a humidified incubator and were mycoplasma-free.
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PMC8009078
In Glide docking, molecules having a higher Glide score compare to Camostat and Ambroxol were removed for further assessment.
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PMC11655498
In this review, we summarize the current progress of the identified factors controlling EBV reactivation and provide an overview of how these key factors co-operate to regulate this process.
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PMC11594641
Additionally, the silencing of RAB27A did not affect the number and mean size of the sEVs, despite some alterations in the protein content of the vesicles.
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PMC11715644
However, unlike the known durotaxis phenomenon for cell migration from soft to stiff regions, it remains unclear how epithelial collectives migrate from open (unconfined) substrates into confined regions.
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PMC11626627
Then, through TargetScan website, we predicted 5751 downstream target genes of miR-204–3p.
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PMC10999934
The expression of overlapping genes in the GSE154600 dataset. (
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PMC9611901
From a toxicological point of view, this is not surprising, considering that the chromium (III) used for tanning is a less hazardous species than chromium (VI) .
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PMC10747160
For the Griffithsin pre-incubated with virus protocol, 10 μL of the desired dilution of the requisite Griffithsin variant (WT-Grft, Q-Grft, or GLG-3A) was added to 30 μL of SARS-CoV-2 pseudotyped lentivirus solution and left at room temperature to incubate.
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PMC9429973
SNHG15-siRNA lentivirus SNHG15L1-cNDA lentivirus and NC were transfected into MM cells to knock-down and knock-in lncRNA SNHG15 gene.
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PMC10329074
Although YBX3 was highly expressed in low-grade tumors and less expressed in high-grade tumors according to tumor grade, no significant differences were identified.
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PMC11283030
Similar to cancer cells, immune cells also undergo metabolic programming, which could suppress immune cell function and abrogate immunosurveillance of cancer, ultimately causing immune escape and uncontrolled tumor growth .
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PMC9250505
The combination enhances the effects of cytotoxic chemotherapies via the impairment of DNA repair processes.
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PMC9872547
E6 protein inactivates the P53 tumor suppressor by binding to it and eliminates the sensitivity of cells to checkpoint and apoptosis signals (15).
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PMC11471176
ACE2 expression starts high in a normal cell, then through an unknown mechanism ACE2 is downregulated and this seems to be the cells response to reduce proliferation initially.
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PMC11271278
Super-enhancers were called using H3K27ac ChIP-seq signal using the Homer pipeline.
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PMC11173119
In Turkish FMF patients, the M694V/M694V genotype has been associated with an earlier age of onset and higher frequency of arthritis and arthralgia compared with the other genotypes .
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PMC8973725
Expression of ZNF677 in 533 ccRCC tissues and 72 normal tissues from the TCGA database. (
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PMC11754291
The culture medium was collected prior to irradiation to allow α-MSH accumulation over several hours and because cells were irradiated in PBS to prevent photon absorption and ROS generation.
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PMC10197932
The relative ISTPA was from 38 to 51 mW/cm2.
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PMC9429973
More than half of the patients were classified as high risk according to MIPSS70 (52%), while 35% were intermediate and 13% low risk.
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PMC11747467
Tumor weight was measured after 4 weeks.
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PMC10936243
But here our standard is just the normal cage which is just enough and if we put bedding inside, usually the cat will not sit on the bedding, they will instead sit in the litter tray.
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PMC9429973
2.
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PMC11673128
Conversely, even though resistances bypassing ALK domain compromised lorlatinib activity against AS4 cells, the association between the CD47.DEMs blockade and the third-generation ALKi turned out to be effective, providing an enhancement of phagocytosis able to eliminate off-target resistant cells (Figure 3B and Figure 4A,B).
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PMC5034105
Zika virus (ZIKV) is unique among human-pathogenic flaviviruses by its association with congenital anomalies and trans-placental and sexual human-to-human transmission.
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PMC11783017
C and D) Cellular uptake of Lipo and Lipo-IL11 by L929 and 143B cells after incubation for 8 h using flow cytometry, including fluorescence intensity and cellular uptake percentage. (
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PMC11711871
A recent study proposed that the GR is required for efficient aldosterone-induced transcription via the mineralocorticoid receptor .
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PMC9429973
In pts on RUX therapy, predictors for COVID-19 disease and survival (OS) to COVID-19 are unknown.
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PMC11675244
For example, Wnt-5a and Wnt-7a can suppress oncogenic Wnt signaling by triggering non-canonical Wnt pathways .
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PMC10882807
With the development of sequencing and other technologies, the diversity and biological functions of circRNAs are being extensively explored.
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PMC11610461
Top 10 BP, CC and MF enrichment terms of DEGs. (
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PMC11795610
tudy demonstrated that myricetin effectively suppresses cell proliferation and induces both cell cycle arrest and calcium ion (Ca) influx, without influencing apoptosis.
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PMC11352746
The basic features and components of live-cell imaging include but are not limited to, time-lapse imaging and automation, fluorescent labeling, microscopic techniques, and environmental control (Table 1).
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PMC11738017
The raw values for triplicate experiments of cell viability measurement and the calculated P values are indicated in supplemental Table 4.
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PMC7887261
The most consistent and interesting findings are two new deletions: POMC 3′ UTR c.*28delT and MLNR p.Q334V fs*3del.
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PMC9430060
The model was able to predict how the structure of CCND1 changes in these different cell lines, could simulate different breakpoints, and could predict the impact on gene expression.
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PMC7305184
Combination of DNA vaccine injection and electroporation is most potent DNA delivery for subsequent immune response.
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PMC11794568
The OCR was calculated from the analysis of the kinetic curves obtained from the measurements.
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PMC4355729
These data suggest that the downregulation of PIK3R1 in RCCs correlates with their progression and metastasis.
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PMC11224206
Research is needed toQuantify the contribution of the factors which determine thermal homeostasis during the various stages of preimplantation development.
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PMC11683240
A, PT (1 μg/ml = 0.00952 μM) and different concentrations of α1AT or the respective amount of solvent (H2O) were added directly to CHO-K1 cells and incubated for 40 min at 4 °C to enable PT binding but not internalization.
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PMC11700340
The study analyzed the differences between groups using the Least Significant Difference (LSD) test.
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PMC11781181
FSP1 and FTH1 expression were downregulated in keratinocyte overexpressing miR-375-3p (Fig. 6C and Fig. 7C).
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PMC7823217
This study clearly demonstrated that this 3D‐bioprinted tumor model is not only able to mimic intact GBM, but also applicable to other types of cancers and can be used as a tool to improve the understanding of tumor biology as well as for testing chemotherapeutic drug efficacy.
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PMC11730320
The purple dashed box indicates the deleted region (heterozygous in the parents and homozygous in the proband); red lines indicate paired-end reads with abnormally large insert size and spanning the deletion junction; vertical colored lines within the read pileups indicate substitutions.
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PMC11741577
Agonists for TLRs 1 through 9 have been commercially established (Fig 2A).
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PMC6650823
The authors also evaluated the in vivo brain tumor-penetrating capability and targeting properties of HNPs, as well as the therapeutic efficacy of docetaxel (DTX)-loaded HNPs.
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PMC8414691
Compared to the non-treated samples (NT), microtubule re-polymerization after 5 min (T5) of rewarming give rise to properly shaped asters in control metaphases (mock), while in SRCAP depleted metaphases (RNAi), aster reformation is clearly aberrant with EGFP::α-Tubulin fluorescence marking only one pole spot, together with sparse and disorganized fibers.
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PMC10568263
First, we evaluated the cytotoxicity and HSP70 secretion levels in cell culture with different concentrations paclitaxel (0, 25, and 50 μM correspond to P0, P25, and P50) for 1 day and 3 days (Fig. 11) to observe the behavior of A549 to paclitaxel.
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PMC10975211
Two of these have received particular notice: encapsulation in nanocarriers and conjugation of drug molecules to water-soluble polymers .
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PMC11731614
Tunable resistive pulse sensing (TRPS) determined that the mean size average for RD KDEVs was 97.7 ± 4.5nm with a concentration peak of 72.3 ± 4.5nm (Fig. 1E).
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PMC11496491
The roles of immune cells mediated by TRP channels are varied, ranging from regulation of cell migration and phagocytosis to the production and release of inflammatory mediators.
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PMC8584666
NF-κB activation, which induces inflammation, is augmented in GPI-80-expressing cells.
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PMC11349530
For instance, in squamous cell carcinoma model, IL-33 was found to be the most significantly upregulated cytokine in TGF-β-responsive TICs (65).
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PMC11472639
Once diagnosed with symptomatic myeloma, younger and/or relatively more physically fit patients, as determined by a haematologist, receive a combination of drugs such as anti-CD38 monoclonal antibody (mAb) therapy (e.g., daratumumab) alongside bortezomib, thalidomide, and dexamethasone (D-VTD) to control and manage the disease prior to a haematopoietic stem cell transplant (Moreau et al., 2019).
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PMC8633974
With lentiviral transduction at an MOI of 1, the TatDE CRISPR transgene was detected at an average of 33.2 spCas9 RNA copies per ACH2 T cell, with a 94% reduction in RT activity and clear viral excision.
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PMC9429973
In our study CVC employed were Shaldon or Hickman.
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PMC11306331
n.s.:
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PMC11599565
Panel E: multidrug resistance in cells with stemness and neuronal phenotype.
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PMC11612508
This solution was then shaken at 25 ℃ to form uniform loaded microspheres.
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PMC11806818
During malignant transformation of hepatocytes, several oncogenic cell signaling molecules such as Golgi protein 73 (GP73) and Glypican-3 (GPC3) are expressed and secreted into the bloodstream .
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PMC9509578
Table 2 lists the various types of polymeric nanomaterials that have been investigated for the reversal of cancer MDR.
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PMC11562028
The fluorescence intensity in the A498 cells at the Re-CDs concentration of 90 μg mL increased by ∼90.5% (p < 0.001) (Fig. 4F).
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PMC3035438
The blots were blocked in PBST (1x PBS, 0.05% Tween) with 5% skim milk, incubated with the appropriate primary antibody [1:10 000 HFP-conjugated anti-human IgG-Fc (Bethyl), HFP-conjugated anti-chicken IgM (Bethyl) or 1:5000 anti-FLAG antibody (Sigma)] diluted in PBST with 1% skim milk for 1 h at room temperature, then with a secondary antibody if necessary [1:10 000 HFP-conjugated anti-mouse IgG (sigma) for the anti-FLAG immunoblotting].
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PMC6901583
An unpaired two-tailed Student’s t-test was used for analyzing two data sets, and one-way analysis of variance was used for more sets.
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PMC11592008
In contrast, GSDMD and ASC protein expression levels did not correlate with their mRNA expression levels.
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PMC11765988
In a meta-analysis, sarcoidosis was associated with an almost three times higher risk of Hodgkin’s lymphoma and a 1.43 times increased risk of non-Hodgkin’s lymphoma .
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PMC11265931
These findings suggest that garlic SEVs are involved in apoptosis as well as the antiproliferative action of garlic SEVs on cancer cell lines (Subash-Babu et al., 2017).
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PMC11703992
Different activated proteins revealed the potential approaches of inflammation maintained by DDIT4+ CD4+ Memory T cells in GCA.
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