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PMC11748335
Further analysis of LOCKs in different DNA methylation contexts shows that long LOCKs are primarily located in partially methylated domains (PMDs), particularly in short-PMDs, where they are most likely responsible for the low expressions of oncogenes.
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PMC11705547
In a phase II trial conducted on cisplatin-resistant bladder cancer patients, neoadjuvant treatment with the anti-PD-1 antibody pembrolizumab prior to radical cystectomy effectively reduced tumor progression .
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PMC10253973
They considered four different monoaqua and diaqua complexes of NAMI-A: [trans-RuCl3(H2O)-(3H-imidazole)(dmso)] (82), [trans-RuCl2(H2O)2(3H-imidazole)(dmso)] (83), [trans-RuCl3(H2O)(4-amino-1,2,4-triazole)(dmso)] (84) and trans-RuCl2(H2O)2(4-amino-1,2,4-triazole)(dmso)] (85), where dmso = dimethyl sulfoxide (Figure 36).
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PMC10174970
At the same time, Deer et al. compared phenotype and genotype of 11 PAAD cell lines, revealing that sufficient discrepancies exist in them (17).
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PMC11252033
1 ng of in vitro transcribed R. luciferase RNA (as internal control) was added, and total RNA was extracted using RNAqueous total RNA Isolation kit (ThermoFisher, United States).
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PMC11585254
The BRET ratio was calculated as the emission signal at 515 +/− 30 nm divided by the emission signal at 410 +/− 80 nm.
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PMC11704135
These findings shed light on the intricate relationship between chemical modifications and biological properties, offering valuable insights for future drug discovery endeavors.
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PMC6468656
The PCR products were gel-purified, digested with NheI/EcoRI, and subcloned into lentiviral expression vector pLAS3W (RNAi Core, Academia Sinica, Taipei, Taiwan).
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PMC11734514
The purity of the RNA was assessed through the A260/A280 ratio by the Infinite M200 PRO microplate reader (Tecan, Mӓnnedorf, Switzerland).
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PMC10761218
Breast cancer is the major cause of morbidity in women, whereas prostate cancer is the major cause of morbidity in men.
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PMC11298021
The expression pattern of miR-155, miR-576-5p, miR-501-3p, miR-3143, miR-3182, and miR-99a/100 in T-ALL cell line were confirmed against healthy controls.
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PMC11536589
The active β-catenin protein levels in AsPC1 and AsPC1-MR cells were assessed by western blot.
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PMC7305184
At the same time, chosen threshold caused 80% in permeabilization assay, which from permeabilization perspective was actually a high administrated dose.
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PMC10387886
Real-time quantitative PCR (qPCR) analyses were performed on StepOne Plus (ThermoFischer, U.S.A) using gene expression master mix (Promega, A6101) and gene-specific TaqMan probes (ThermoFisher).
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PMC10882807
Quantitative reverse transcription-polymerase chain reaction(qRT-PCR) was used to measure the expression level of hsa_circ_0005397 and EIF4A3 from paired HCC tissues and cell lines.
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PMC11696576
To measure AA release, the cells were labeled overnight with H-AA (0.4 μCi/mL) in serum-free DMEM and then washed twice with PBS containing fBSA (2 mg/mL) to remove unincorporated radioactivity.
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PMC9065483
EGFR inhibition using gefitinib and erlotinib, or of MEK1/2 (using UO126), dose-dependently decreased the vanadate-enhanced growth of VSVΔ51 tagged with a GFP marker in 786-0 cells as determined by phase and fluorescent microscopy images captured 24 h post infection (hpi) (Figures 2B, S5, and S6).
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PMC11521786
They were then permeabilized with a solution containing 0.1% (m:v) sodium citrate and 0.1% (v:v) Triton X-100 for 2 min at 4°C.
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PMC11704834
To examine TLE1 expression in patients with EGFR-TKI resistant and sensitive LUAD, the Gene Expression Omnibus (GEO) Datasets (http://www.ncbi.nlm.nih.gov/geo/gds), hosted by the National Center for Biotechnology Information (NCBI), was employed as the database for dataset retrieval.
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PMC11055443
They also reported that the TNF-α/IL-10 ratio was decreased after successive secretome treatment (17).
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PMC9220170
Cell migration to the “wound” area was monitored using a microscope after 24 and 48 h. It can be seen that there were no significant differences in the control sample and separately in the samples with SELENOM-KD (Figure 2a,b) and SELENOT-KD (Figure 2c,d).
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PMC9429973
Results: Totally 140 patients were included into analysis, 68 males (48.6 %), 72 females (51.4 %), in the age 23-86 years old, median age 63 years (95 % CІ 60;65).
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PMC7812570
Subsequently, the DSP-based fusion assay was conducted to quantitate the inhibitory activities of GPI-m36.4 and GPI-FluIgG03 in viral Env-mediated cell–cell fusion.
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PMC11732628
The cells were observed using a light microscope.
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PMC11637276
This suggests the intriguing possibility that during embryonic development migrating cells remodel the surrounding ECM via macropinocytosis.
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PMC11515150
Recently, natural killer (NK) cells have exhibited “off‑the‑shelf” availability.
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PMC10788478
Recent progress in immuno‐oncology has led to the exploitation of immune checkpoint inhibitors (ICIs) against lung cancer, whereas the prognosis of patients with advanced lung cancer remains unsatisfactory.
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PMC5173112
G, H) ALDHhigh cell percentage in A-704 cells transfected with control or USP21 siRNA.
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PMC11618052
The most potent compounds were further tested as dual inhibitors of EGFR/BRAF.
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PMC9429973
YTB323 is an autologous CD19-directed CAR-T cell tx generated by the innovative T-Charge™ platform, which demonstrates high potency, preserves T-cell stemness in the final product, and takes <2 d to manufacture.
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PMC5363531
This data suggest a dasatinib regulation, through SRC inhibition, on those transcription factors having responsive elements in the region of TS promoter here adopted.
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PMC11583690
However, since no studies have been conducted on DTX and BPMO, a comprehensive evaluation is needed.
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PMC11144200
Next, we looked into the possibility that LPS-RGD-Nb36-DOX might attach to stimulated CD8 T cells specifically.
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PMC11279598
Statistical differences regarding in vitro cell proliferation and/or apoptosis assays were analyzed using Student’s t-test.
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PMC11655498
This approach can guide the development of specific small-molecule drugs through virtual screening.
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PMC9424261
Cells were resuspended in 200 μL PBS containing BODIPY 581/591 C11 (D3861, Thermo Fisher, Waltham, MA, USA) and incubated at 37 °C in the dark for 10 min.
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PMC9429973
While a prospective stratification of the patients is difficult to achievable, we aimed to investigate whether a further optimized dose reduction scheme prior to stopping could further improve TFR.
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PMC11684269
The majority of blood in the kidney fuels the renal cortex, attributing to the only 10%-15% blood supply to the renal medulla.
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PMC11502327
The experimental results showed that Fisetin could down-regulate the expression of Bcl-2 and up-regulate the expression of Bax, briking the balance between Bax and Bcl-2.
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PMC11792090
Similarly, to assess whether CD47 UCAR-T cells can withstand macrophage killing, macrophages and UCAR-T cells were labeled with different fluorescent dyes and co-cultured at an effector-to-target (E: T) ratio of 1:1.
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PMC11789597
The total flux in each mouse after inoculation for the indicated days was determined.
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PMC11424574
Overall, these findings suggest that uPA may be a biomarker for osteosarcoma and that involved in the molecular mechanism underlying of the involvement of MTA2 in human osteosarcoma metastasis.
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PMC9429973
TN cases clustered with specific M-GVs, potentially targetable (IDH2).
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PMC11423992
PBMC (lot. #
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PMC6163708
Ectopic INI1 is able to rescue the nonmalignant phenotype in rhabdoid tumor cell lines.
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PMC11740508
In support of this model, early studies of DNMTi treatment effects reported induction of DNA damage signaling, apoptosis, and production of aberrant DNA structures that are most constant with replication fork collapse and which require HRR for correct resolution .
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PMC9275501
Natural active ingredients combined with chemotherapy drugs can affect on tumor tissues from multiple targets and pathways, and reduce its toxicity by reducing the dosage of chemotherapy drugs.
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PMC11750161
To assess the function of potential phosphorylation sites in cAMP signal transduction, eel LH/CGR-wt was truncated at amino acid 651 of the C-terminal region and the truncated mutant was referred to as eLH/CGR-t651.
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PMC11574271
This observation was supported by our findings in J82-oeRON cells with high RON expression, where the suppression of HIF-2α expression resulted in a reduction in MMP12 levels (Fig. 4E).
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PMC9516447
This effect was at the post-transcriptional level and is independent of proteasomal degradation or autophagy.
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PMC11763764
Cell lysate (500 μL, 1 μg/ μL) was incubated with the beads for one hour at room temperature on a rotating mixer.
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PMC10812665
In a PCA plot, all toxicant-exposed samples clearly separated away from the control, and also from one another, i.e., the replicates of a given toxicant clustered more closely together than the average values of the different mitotoxicants.
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PMC11488203
Original Western blot data are documented in suppl.
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PMC11707577
Conversely, HSA‐TM bioconjugates poorly permeated the A431 spheroids, as shown by the lower fluorescence signals in the oligothiophene channel, compared to spheroid treated with M13EGFR(TNP).
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PMC11155445
Complexes (75d and 75e) showed better anticancer activity with IC50 values of 8.74 and 5.37 μM against (A549) and 10.76 and 21.36 μM against (cis RA549) cell lines, respectively.
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PMC7612475
P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; NS, nonsignificant.
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PMC11127909
D WB analysis of c-Myc, cleaved caspase 3 (C–C3) and cleaved caspase 9 (C–C9) expression in 143B-V, 143B-EFHD1, 143BR-shV and 143BR-shEFHD1 cells after cisplatin treatment, N = 3.
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PMC9878562
Preincubation of VAL-ko with PTX inhibited their migration ( Figure 5Aiii ), suggesting that the migration of VAL-ko in the presence of VAL-wt depends on the activation of a chemotactic Gi/o-protein coupled receptor.
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PMC11322866
In fact, EZH2 alters the expression of its downstream target genes through H3K27me3.
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PMC11488203
After size exclusion chromatography (SEC) the 500 µl fractions were analysed by NTA and reproducibly revealed the maximal EV-concentrations in fractions 5 and 6 which were pooled, respectively.
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PMC8633974
No recorded off-target cleavages were detected.
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PMC7057940
These patients had a lung biopsy and histopathological examinations between October and December 2016.
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PMC9429973
Inclusion criteria: age >18 years, FLT3-mutated AML diagnosis according to WHO criteria and start of treatment with midostaurin in combination with IC between June 2016 and June 2021.
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PMC11012313
After 24 h, protein lysates were generated by first lysing cells using Ripa Lysis Buffer containing Halt™ Protease and Phosphatase Inhibitors (Thermo Fisher Scientific).
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PMC11544771
The lower right and upper right quadrants in the histograms represent the early and late apoptotic cells, respectively.
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PMC11406030
Multivariable analysis was subsequently performed, incorporating nuclear intensity, cytoplasmic intensity, histotype, stage, and age to assess the independent prognostic effects of LMTK3 (Table 2B).
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PMC11597167
Given its central role in Aβ production and AD pathology, BACE1 has emerged as a promising therapeutic target for the treatment of AD .
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PMC11763764
In this study, the primary and recurrent tumor samples were collected from patients who were diagnosed with high-grade serous ovarian cancer.
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PMC11531735
Whole head tumor fluorescent intensity per day and (C) brain tissue images after sacrifice on Day 24 showed significantly reduced tumor growth in treatment group as compared to control.
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PMC5035325
Primary tumor volume in 4T1-model (f).
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PMC11541409
Other mutations, as in cell lines (P815, Kasumi-1, Ba/F3), show moderate to high resistance to imatinib .
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PMC4355729
For the protein expression of PIK3R1, the formalin-fixed, paraffin-embedded (FFPE) tissue samples of patient-matched normal renal, pRCC and mRCC tissues from 13 patients who underwent nephrectomy between May 2008 and April 2013 were obtained from the archives of the Zhujiang Hospital of the Southern Medical University (Supplementary table 1).
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PMC11490153
The treated plates were then incubated for 24 h at normoxic (74% N2, 5% CO2, and 21% O2) or hypoxic (94% N2, 5% CO2, and 1% O2) conditions.
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PMC10743717
However, sons of the female carriers of HSD17B10 mutations are at high risk of suffering from this inherited metabolic disease.
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PMC11473750
d Schematic of targeted RNF121 conditional allele: Two sgRNAs (yellow) were complexed with Cas9 nuclease to generate double stranded breaks in the RNF121 locus.
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PMC10197932
Another important aspect is considering the effects of US on the expression of early activation markers such as CD69, or specific CD8+ T cytotoxic effector marker CD137 and Granzymes production.
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PMC10957991
Tension itself is also directly regulating TRPV4 expression.
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PMC9429973
B symptoms occurred in 19 cases (76%).
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PMC6133382
In contrast, binding to the 10–1074 bN-mAb, also in the PGT121 family, was unaffected by the cellular substrate used for production.
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PMC9966931
The modes of action of these natural bioactive compounds are under intense investigation, although some of them have been relatively well described.
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PMC9429973
Aims: We aimed to investigate the durability of immune responses to COVID-19 vaccination in patients with MM or B-CLL compared to healthy controls, and to identify risk factors for humoral non-response, including type of diagnosis.
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PMC7022782
Based on the obtained results, the formulation ICG-NPs1 was selected for further experiments.
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PMC11655536
Cells were grown in a humidified atmosphere containing 5% CO2 at 37 °C, Hexamethylene amiloride (HA) was purchased from MedChemExpress (Shanghai, China).
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PMC11224020
Left, percentage of CD69CD4 T cells among live cells after 18 h of incubation with OVA peptide II (OVAp).
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PMC8623816
We purified the viral particles using the sucrose-gradient method described by Sanderlin and Ghabrial with minor modifications.
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PMC9429973
Furthermore, we highlight the possibility of intermittent (int.)
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PMC11574271
C The invasive potential was evaluated using a trans-well assay.
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PMC11543853
The high multiplicity of infection probably enabled enteroviruses to enter cells using multiple mechanisms of internalization, and the observed membrane rupture may not represent the most abundant physiological process in the context of a low multiplicity of infection.
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PMC9587866
The stereochemical features of this model showed that 95.8 % of amino acids were in favorable region and 3.8 % were in additionally allowed region, whereas single residue SER438 was in disallowed region in the Ramachandran plot.
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PMC9429973
Ibrutinib irreversibly targets Bruton’s tyrosine kinase (BTK), thus interrupting B-cell receptor signaling.
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PMC6442998
To further support these observations, we performed a double immunofluorescence staining for αSMA and KIT on both cell lines.
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PMC11321678
Cells were transient transfected with plasmids by LipofectamineTM 2000 Transfection Reagent (Invitrogen) according to the manufacturer's instructions.
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PMC11594588
During activation, GDP is released from the α subunit to bind to the GTP protein, and then the α-GTP complex dissociates from the β γ subunits .
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PMC11718109
Further analysis on fluorescence recovery was performed with ImageJ plugin, FRAP Analysis.
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PMC11787381
Results are expressed as mean ± SEM [n = 12 except for (A): control (n = 11) and (C): bambuterol (n = 11)].
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PMC6684588
P ≤ 0.001 vs. vehicle; P ≤ 0.001 vs. uninjected (contralateral) TA by one-way ANOVA with Tukey’s adjustment. (
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PMC11587606
We found that high levels of RHBDF1 disrupted TJ/AJ formation.
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PMC9429973
According to IMWG, ORR was 63% (51/81: 7 CR, 18 VGPR, 15 PR, 11 MR) with11 PD and 19 patients in SD, which can be considered as an impressive resultin this subset of rrMM patients.
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PMC5833712
In addition, the cellular sensitivity to cisplatin and the additive effect of KB9520 was lost (Fig. 5e, f, S4).
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PMC11469524
This can be proposed based on a SILAC-based phosphoproteomics study which observed, that TRRAP is upregulated after 15 min EGF stimulation and downregulated by EGF stimulation and p38 inhibitor (SB202190) treatment in HeLa cells .
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