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PMC11682525
This downregulation could potentially be attributed to a negative feedback loop, where prolonged exposure to hypoxia triggers the degradation of HIF1α, limiting excessive gene expression ( 49 ).
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PMC6268318
Antifungal activity was reported in models that used Epidermophyton floccosum, Microsporum gypseum, Trichophyton mentagrophytes, T. rubrum, Candida albicans, C. neoformans, Aspergillus fumigatus, Sporothrix schenckii and Microsporum canis .
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PMC11438317
FYB and PSTPIP1 plasmids have been described before .
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PMC8735881
For an overall comparison, the data were also summarized in Figure 3(A-C).
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PMC11435360
Therefore, it will be important to verify the presence, if any, of these off-target effects in the treatment of BC with PAG.
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PMC7369657
Cytotoxic agents such as radiation, nitrogen monoxide, arsenic, alloxan, streptozotocin, doxorubicin, mercury, and copper nanostructures induce apoptosis involving the mitochondria.
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PMC11604768
Next, to replicate the promoter sequence of our TRE-minCMV screening plasmids, annealed oligonucleotides containing restriction enzyme recognition sites were ligated to pGL4.R_minCMV digested with KpnI (pGL4.R_TRE_minCMV).
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PMC8358176
The results of 72-h cell viability assay (MTT test) in Jurkat cell line showed that carboxylic forms of SWCNT and MWCNT at the concentration of 100 µg ml- had no significant effect on the cell viability.
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PMC8751435
These results present differentiated effect of CME on activating GSDME in comparison with outcome in western blotting.
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PMC11453018
B Venn diagram shows the overlap of DEGs in ES cells post P300/CBP inhibition, with a predominant downregulation of gene expression.
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PMC7351993
Fourth, the throughput of the RIACS can be increased by increasing the flow rate and reducing the calculation time on the real-time Raman image processor at the expense of the signal-to-noise ratio of the SRS signal acquisition, which currently limits the maximum throughput.
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PMC10547921
There is no F ring in payload 59, but its conjugates have similar efficacy in vitro and in vivo as those containing DXd.
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PMC9429973
aaIPI was high (>1) in 45% of the cases.
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PMC11766309
In vitro analysis confirmed that YKT6 was highly expressed in advanced-grade CESCs and that the knockdown of YKT6 inhibited the proliferation of cervical cancer cells.
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PMC9429973
However, the most common haplotypes A*24:02~B*35:02~C*04:01~DRB1*11:04~DQB1*03:01 (1.38%) and A*33:01g~B*14:02g ~C*08:02g~DRB1*01:02g~DQB1*05:01g (1.38%) were mainly attributed to Rethymno with frequencies of 3.35% and 1.96%, respectively.
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PMC11713609
Taken together, these data demonstrate that PHLDA2-dependent ferroptosis, but not ACSL4-dependent ferroptosis, occurring naturally in vivo upon ROS-induced stress, plays a critical role in p53-mediated tumor suppression (Figure 1O).
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PMC10719213
These results are in line with the results obtained previously in bacteria or mammalian cells, before the next-generation sequencing era, which suggested that cladribine is not mutagenic in vitro .
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PMC11476004
The researchers noted a higher frequency of SCEs in cancer patients .
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PMC11697703
We thank members of the S.T. and M.J.G. labs.
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PMC11544771
In addition, CPX treatment also dose-dependently increased the ATR-mediated phosphorylation of Chk1 on S345 as well as the autophosphorylation of Chk1 on S296, despite dose-dependently reducing the protein level of Chk1 in the cells (Figure 3A,B and Figure S1).
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PMC11283030
This data indicates that ACLY knockdown could attenuate the proliferation ability of ccRCC cells.
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PMC11672617
The authors posit that lithocholic acid induces substantial alterations in the mitochondrial membrane lipidome, which, in turn, give rise to notable modifications in mitochondrial morphology.
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PMC9429973
With a median follow-up of 48.8 months, there were no significant differences in the time to start of new treatment between WW and RT groups (median: both not reached [NR], p = 0.187) and between WW and R groups (median: NR vs. 69.0 months, p = 0.554).
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PMC9776316
Crystal violet (0.5%) was used to stain the colonies.
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PMC2191929
These data implicate granzymes as the major mediators of tumor target damage by cytotoxic lymphocytes.
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PMC11533140
A docking study of compounds 17e and 17p was conducted to assess the rationality of the designed strategy; we selected the co-crystal structure of BMK-120 with PI3Kα (PDB: 3ZIM) as the docking mode.
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PMC11419566
The purpose of this review was to better understand the potential mechanism of anticancer activity of PA and to provide direction for future discoveries and researches on anticancer drugs.
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PMC11422497
However, there is currently no research on miR-494-3p in GISTs.
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PMC10142392
The micelles, both empty and DOX-loaded, were spherical with average sizes of 63 and 110 nm, respectively.
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PMC2614415
This network is based on the published interactions [16,40-51] present in the Ingenuity Pathways knowledgebase.
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PMC10873328
Evaluation of TGFBI sensitivity to chemotherapy drugs on tumor. (
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PMC7342409
The immunohistochemical detection of caspase 3 protein expression in rat tumor tissue. (
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PMC10253553
The cells (786-0) were treated with increasing (2, 10, 50, 250, and 1000 nM) concentrations of rapamycin or Torin 2 for 24 h. The results showed a statistically significant increase in the accumulation of cleaved-PARP in response to increasing concentrations of Torin 2 (Figure 6B).
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PMC9429973
When patients were asked to report AEs of higher intensity the most frequently reported were general (31.6%), genitourinary (26.3%), gastrointestinal (23.7%), neurological (15.8%) and cutaneous (13.2%) symptoms (Figure 1).
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PMC8526701
The expression of GAPDH was used for normalization.
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PMC9920575
These treatment modalities are applied independent of the histology of the disease, which may impact prognosis as well as response to treatment .
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PMC10847511
In contrast, there have been limited reports investigating the association by comparing multiple cell lines derived from different backgrounds.
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PMC11536589
Pretreatment with DFO (10 µM) or Fer-1 (2 µM) for 4 h and the other indicated drugs was carried out for 48 h. (E, F) The lipid peroxidation was assessed by BODIPY 581/591 C11 probe using a flow cytometer after the 1 µM MRTX1133 treatment for 48 h. (G) The intracellular MDA level was assessed after the 1 µM MRTX1133 treatment for 48 h. (H) The intracellular GSH level was assessed after the 1 µM MRTX1133 treatment for 48 h. Data represent means ± SEM from three independent experiments.
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PMC11621493
Data were normalized to IS and total protein content.
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PMC4443654
Unexpectedly, we found that boundaries marked by YY1 (without overlapping CTCF peaks) were generally most strongly enriched for other features in our dataset.
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PMC6771295
However, other factors such as the contribution of the microenvironmental conditions in fine tuning the enzymatic activities of sirtuins and hence the autophagy process require further investigation.
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PMC10936243
There have been no studies as yet exploring the barriers Malaysian veterinarians face as they seek to provide good post-operative care for cats in practices.
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PMC11476837
Moreover, we took a closer look at the expression of NRF2-regulated genes upon using NRF2 inhibitors.
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PMC11026382
We omitted downstream reactions of folate metabolism that use one-carbon derivatives of THF in the production of purine precursors, glycine, and methionine (dashed lines in Fig. 1b), as none of these other reactions oxidize THF back to DHF—they instead add or subtract one-carbon units from the reduced THF.
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PMC11502327
Bondì et al. (184) embedded curcumin into SLNs to improve its bioavailability and antitumor activity.
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PMC4839679
Cell adhesion is essential in adherent cells serving as molecular scaffolds linking the cellular cytoskeleton to the extracellular environment .
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PMC11519567
two-sided, unpaired t test, **P < 0.01.
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PMC9429973
The on-treatment costs were largely driven by medication costs ($15,203 PPPM) compared to medical costs ($3,349 PPPM).
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PMC11790971
Based on the selected image channel(s), cellular features were extracted and processed following the same procedure as the aforementioned analysis using all imaging modalities.
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PMC9429973
on days 1-5, romidepsin 14 mg/m2 on day 8, 15 and 22 of a 35 day cycle; and Schedule C (total of 2 patients): azacitidine 75mg/m2 s.c.
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PMC5916734
Each reaction was repeated 3 times in a volume of 25 µl in 3–5 replicas.
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PMC11286266
On the right, DNA sequence chromatograms of FURIN-targeted region are represented, showcasing parental cells and an FURIN∆ clone.
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PMC6461034
Results are visualized in a scatter plot of INKA scores for kinases scoring ≥ 10% of the maximum (“INKA Plot”; horizontal shifts from the middle indicate evidence being more kinase‐centric or more substrate‐centric).
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PMC9046263
Similarly, several DEGs found in the A172 cell line were directly involved in cell division and growth.
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PMC9429973
The AL subtype is linked to a poor survival rate because of the frequent malignant nature of the underlying disease and the high cardiac toxicity of the monoclonal light chains.
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PMC9429973
The PB donor chimerism of Ddx41 and Ddx41 mice-derived cells was markedly reduced compared to that of Ddx41 cells.
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PMC11536589
The Gene set enrichment analysis (GSEA) were conducted with GSEA software (Subramanian et al. 2005).
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PMC11637276
We observed that MDA-MB-231 cells seeded on 2D collagen I internalised and acidified collagen I while migrating (Fig 5A and S2 Video), suggesting that ECM endocytosis might facilitate cell migration.
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PMC11352666
Thus, agents targeting MERTK are expected to provide therapeutic activity via multiple mechanisms, including direct tumor cell killing, inhibition of metastasis, and activation of anti-tumor immunity.
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PMC11322866
In this study, we found that RRM2 overexpression inhibited EZH2 and induced cellular senescence simultaneously.
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PMC11301242
The initial discovery of ecDNA traces back to the 1960s .
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PMC11742290
Knockdown of LGR5 induced apoptosis in colon , breast , and neural cancers.
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PMC9429973
The severity of majority of the AE were grade 2 and 3 (26.7 & 25.2%, respectively) while SAE were grade 3 & 4 (3.5% & 4.4%, respectively).
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PMC11248911
Calcd.
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PMC5925824
CD14 monocytes were isolated from frozen human peripheral blood mononuclear cells (PBMC) obtained from a healthy donor (AllCells, Alameda, CA) with Human Monocyte Isolation Kit II (Miltenyi, Auburn, CA).
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PMC5925824
Purified proteins were buffer exchanged into PBS, quantified and evaluated by SDS-PAGE and analytical SEC analysis to confirm structural integrity.
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PMC11609529
Furthermore, to investigate if the YM fusion can constitutively activate YAP1-mediated transcription, we conducted a luciferase reporter assay using a YAP1/TEAD-responsive promoter reporter.
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PMC2118063
Chromatin immunoprecipitation studies demonstrated in vivo occupancy of 5′ sequences of both genes by IRF8 protein.
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PMC11806182
We also found significant immune cell composition changes linked to miR-330 expression, with pro-inflammatory and exhausted immune subsets being up-regulated in high miR-330 samples, indicating an unfavorable immune microenvironment in UCEC.
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PMC9065483
Cells were lysed 24 hpi, fractionated for cytoplasmic and nuclear fractions, then probed for phosphorylated NF-κB/p65, NF-κB/p65, lamin B1, and ɑ-tubulin. (
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PMC10530622
This mutation, when in cis with the minor p.P11L/p.
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PMC9429973
No relapses were observed in patients who achieved ORR after 4 cycles.
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PMC11551844
Similar fractions were combined together based on thin layer chromatography (TLC) observations.
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PMC11705630
And we found that STAT2 was not phosphorylated by suppression of GLDC (Fig. S1B).
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PMC10840195
Then, samples were collected in the order of coIP group, input1, marker, IP group and input2, and Western blotting analysis was carried out.
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PMC11743975
Tom20-CIBN-GFP is reported as targeting mitochondria and interacting with CRY2clust.
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PMC11267830
RBM39 has been identified as a critical oncogenic factor in T-ALL pathogenesis.
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PMC11767725
For instance, C. acnes, a dominant commensal in sebaceous-rich areas, relies on triglycerides and unsaturated fatty acids for its metabolic processes.
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PMC11406030
This combined variable, termed “cytoplasmic:nuclear LMTK3 balance,” was categorized into three groups: cytoplasmic staining < nuclear staining, cytoplasmic staining = nuclear staining, and cytoplasmic staining > nuclear staining.
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PMC11766350
HEK293F cells were transfected with either the anti-gfp shRNA-containing pAAV-gfp-TRAIL or scrambled shRNA-containing pAAV-gfp-TRAIL plasmids, along with pRep2/Cap5 and pHelper.
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PMC11676674
Furthermore, the methanolic extract of C. incanus demonstrated IC50 values of 57.80, 383.61, and 343.40 µg/mL against human malignant melanoma (A375), human squamous cell carcinoma (SCC-15), and non-cancerous human keratinocyte (HaCaT) cell lines, respectively.
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PMC6379402
For a given gene and for a given cancer, we report the most significantly different survival curves that are obtained over all possible values of the expression threshold.
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PMC9844987
Indeed, comparison of +1 nucleosome positioning relative to the dominant TSS position of promoters across the panel revealed that low variable promoters tend to have stronger +1 nucleosome positioning (Figure 4—figure supplement 2A and B).
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PMC10887351
The involvement of β3-ARs in cancer initiation/progression suggested that they could be an interesting target for novel anti-tumoral and therapeutic approaches.
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PMC3765139
C: 40× magnification (scale bar 50 μm).
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PMC6442998
ICC coordinate gut motility as they mediate inputs from the enteric nervous system and elicit pacemaker activity throughout the smooth muscle layers of the digestive tract .
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PMC7841189
Furthermore, knockdown of LTBP2 attenuates thyroid carcinoma growth in nude mice.
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PMC5963610
However, the difference between NGc and N-Acetylated (NAc) variants of GM3 regarding such interactions is unknown.
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PMC7039683
The significance of enrichment of each of the shared motifs among hOEAEs, mPEAEs and zPEAEs.
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PMC11721295
We orthotopically implanted KRAS-mutant KPL-86 cells derived from the KP model into the lungs of mice, and then treated mice with MRTX for 2 days at 30 mg/kg twice daily by i.p.
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PMC9503685
Pluronics (poloxamers), a drug delivery system, are water-soluble triblock copolymers consisting of polyethylene oxide-polypropylene oxide-polyethylene oxide (PEO-PPO-PEO) and have been approved for pharmaceutical use by FDA.
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PMC9219615
Thus, cells that co-localize both red and blue signals, exhibiting a magenta color, are defined as the dead/dying population.
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PMC10170482
n = 4–8 samples out of three independent experiments. (**)
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PMC11779993
The 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay was conducted following the previously described method and demonstrated as μmol Trolox/g extract .
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PMC7802142
2ReN-NV enter into DPCs and promote their proliferation.
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PMC11539788
All the experiments were repeated at least in triplicate.
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PMC9429973
Results: Fifteen newly diagnosed MM patients had received D-RVd in the time period of the study.
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PMC11509278
Each experiment had six replicates, and equal volumes of samples were taken from each experimental sample and mixed as QC samples.
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PMC11055510
The cell nuclei were stained with 4,6-diamidino-2-phenylindole (DAPI; Beyotime).
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PMC9429973
Methods: We conducted a retrospective analysis of outcomes in adult pts with Ph-negative B-cell ALL who relapsed or were refractory to both INO/Blina, at least one of which given as salvage therapy.
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