Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC11718031
It was found that lactate levels increased until day 5 when peak VCC was reached.
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PMC11765678
Ferroptosis inducers, like ER and RSL3, have shown promise in sensitizing resistant tumor cells to various chemotherapeutic agents and have emerged as promising candidates for addressing MDR.
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PMC11281366
In conclusion, our study identifies miRNA-26a as a post-transcriptional negative regulator of CD59 expression in CD4 T cells.
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PMC11740573
All isolates showed concordance with the MIC values when tested in duplicates.
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PMC11540664
In this study, we assessed whether peripheral blood lymphocyte count could be used as a prognostic marker for the combination regimen and found that patients with low lymphocyte counts did not receive additional benefit from the combination regimen compared with single-agent targeting.
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PMC11285179
The graphs visually illustrate cell migration distance and quantity (Fig. 2E, left panel).
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PMC10938377
Elemental analyses were determined on a Thermo Scientific Flash 2000 Organic Elemental Analyzer.
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PMC11593084
Although the target cell-derived immunosuppressive factors such as PD-L1 or TGF-β would contribute to the responses, the reactivity of PMab-117-mG2a in PC-10 is sufficient to exert ADCC and antitumor efficacy in vivo.
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PMC11507371
This great advantage, compared to most conventional cancer treatments, displayed great potential for using CAP in oncotherapy, thus driving further investigations.
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PMC4270159
Each condition will be run in triplicate.
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PMC9429973
Thirty-eight percent of participants had been treated with chemotherapy alone, while 62% received at least one allogeneic stem cell transplant (alloHSCT).
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PMC10170482
Of note, it was shown that dormant tumor cells express low levels of Ki-67.
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PMC6600253
In addition, telomeres also contain special structures and associated proteins and assume a variety of conformations, all of which contribute to the activity of telomerase .
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PMC11615828
Every four days, one‐third of the fresh NB/B‐27 medium without glutamate was added to maintain the cell health.
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PMC11476106
These findings reflect a high variability in cell adaptation and behavior among cell lines.
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PMC11612315
The membrane was washed with TBST and incubated for 1 h with the secondary antibody, anti-rabbit Ig-HRP (1:10,000, 9910; Cell Signaling Technology, Danvers, MA).
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PMC9429973
M Kimura, N. Asada, M. Matsuda, M. Abe, W. Kitamura, K.-I. Matsuoka, H. Fujiwara, M. Ono, W. Ziyi, T. Mukai, Y. Morita, Y. Maeda Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science; Hematology and Oncology, Okayama University Hospital; Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama; Immunology and Molecular Genetics; Rheumatology, Kawasaki Medical School, Kurashiki, Japan Background: Allogeneic stem cell transplantation (allo-SCT) has been considered as a curable therapy for hematologic diseases.
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PMC10158546
We also supplemented the ReN culture media with heparin – a glycosaminoglycan that was shown to promote in vitro prion replication .
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PMC11740207
Disease can independently initiate at various stages.
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PMC11748618
BIMBAM computes multi-SNP Bayes factors of genetic variants against a phenotype of interest, evaluating up to N possible models.
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PMC7841189
For example, Miao and Zhao confirmed that targeting the PI3K/Akt pathway by its specific inhibitor LY294002 or by Akt small interfering RNA (siRNA) resulted in reduced capacity in invasion of thyroid carcinoma cells28.
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PMC11656048
The morphological changes of the OS cells treated with shikonin were also consistent with ferroptosis, which mainly showed that the mitochondria became smaller, the membrane density increased, and the mitochondrial ridge decreased.
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PMC11429241
To achieve an even broader understanding of how scaffolds impact cell growth, the gene expression evaluation was performed.
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PMC11687167
PCSK9 has been reported to play an important role in the genesis, development, and prognosis of GC by promoting the MAPK signaling pathway through upregulation of HSP70, thereby promoting GC metastasis and inhibiting apoptosis .
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PMC11095939
Figure 3—figure supplement 1.Mecp2 is dynamically expressed during quiescence exit in both HT22 and human umbilical vein endothelial cells (HUVECs).Serum restimulation (SR)-induced (A–D, I–L) or contact inhibition loss (CIL)-induced (E–H, M–P) quiescence exits in mouse hippocampal neuronal HT22 cells (A–H) or in HUVECs (I–P) was analyzed by propidium iodide (PI) staining (A, B, E, F, I, J, M, N), real-time PCR (C, G, K, O), and western blotting (WB) (D, H, L, P) in a time course of quiescence exit. (
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PMC11543885
Plot Top Enriched Terms.i.
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PMC9792775
To the best of our knowledge, this study investigated for the first time the potential therapeutic value of LFU in the treatment of sarcoma with PTX.
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PMC4277423
Cas9: Cas9 endonuclease; CR2 sgRNA: single guided RNA CR2; HA: HA epitope tag; NLS: nuclear localization signal; U6: polymerase III U6 promoter sequence; EF1α: promoter sequence derived from elongation factor 1α; 2A: 2A self cleaving peptide sequence; and EGFP: sequence encoding enhanced green fluorescent protein.
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PMC11599565
Curiously, its dark color suggested that they produce neuromelanin (NM), an aspect first addressed using the Fontana-Masson staining which is specific for the histological detection of this pigment and secondly confirmed by the high expression of Tyrosine hydroxylase (TH), a key enzyme in the generation of this pigment, a sub-product of catecholamine metabolism.
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PMC9503685
Pseudomonas aeruginosa is on the priority pathogens list determined by the World Health Organization due to its natural and acquired antimicrobial resistance and virulence factors .
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PMC8956657
To determine the ratio of nuclear to cytoplasmic fluorescence signal (Fn/c), coverslips were imaged using a BioTek Cytation 5 Cell Imaging Multi-Mode reader.
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PMC11577421
To further investigate the interactions between heparin and NP_BSA+, we employed surface plasmon resonance (SPR) spectroscopy, a surface-based technique.
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PMC8873393
Interestingly, all these lncRNAs displayed undisturbed or mild changes in expression in the cytoplasm fraction.
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PMC9429973
We found that the patients who had high CNS-IPI score were at six times greater risk of CNS relapse than those with low and intermediate CNS-IPI score (9.0% and 1.5% after 12 months, 11.6% and 2% after 24 months) (p=0.03).
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PMC6799808
This effect was associated with inhibition of the IGFR-PI3K pathway, activation of the AMPK-TSC2/raptor network, and downregulation of the protein expression of Rheb (Fig. 6).
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PMC9429973
Defibrotide is approved for the treatment of severe VOD/SOS post-HCT in patients aged >1 month in the European Union and for VOD/SOS with renal or pulmonary dysfunction post-HCT in the United States.
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PMC10809689
The findings have shown that the glutaminase activity of L-asparaginase (l-ase) from Escherichia coli and Erwinia chrysanthemi inhibits mTORC1, and protein synthesis, and induces apoptosis in primary AML cells, especially in HL-60 cell line .
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PMC11705067
Specially, FDX1 and DLAT genes were closely associated with EDNRB, CD274, HAVCR2, IL10, TGFB1, LAG3, PDCD1, IL4 and VTCN1 in ccRCC patients.
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PMC9429973
In survival analyses only protein C level was predictive for unfavourable evolution, Wald 8.55, p=0.003.
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PMC5916734
Stably transfected cell populations were obtained in all three cases; the FIX secretion levels determined by ELISA were 0.69 ± 0.04, 1.05 ± 0.05, and 1.83 ± 0.24 µg/ml, respectively; the population doubling time for the cell cultures was 27–29 h. The maximum FIX titer was detected in the culture obtained in the presence of 200 nm MTX; therefore, immunoblotting of the intracellular FIX and FIX secreted by this cell culture was performed (Fig. 2A).
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PMC11627398
Hence, we propose an idea that these genes may have diagnostic potential for other infectious diseases, such as COVID-19.
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PMC10170482
To verify functional changes associated with either MC or CS conditions, cells were subjected to different depolarizing agents’ treatment: ionomycin (ION), 10 min 1 μM; carbonyl cyanide m-chlorophenylhydrazone (CCCP), 30 min 10 μM; and potassium cyanide (KCN), 5 mM, 30 min.
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PMC11459296
We then assessed the feasibility of solid tumor engraftment by s.c.
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PMC9429973
Treatment approaches depend on the type of MDS according to the WHO classification and on risk assessment according to the international prognostic scoring system (IPSS-R).
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PMC11228511
The mice were provided pelleted mouse chow (NIH31) and water ad libitum and nutritional food cups (Westbrook, ME) as required for supportive care.
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PMC9960565
= 1013.47, m/z found = 1013.46 [M+3H] C110H205N30O44Pt2.
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PMC11449273
Cultures were grown for an additional 6 hours at 30°C, harvested by centrifugation at 4,000 x g at 4°C for 12 min and the supernatants were discarded.
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PMC9429973
We received a pretty accurate and balanced model with 3 predictors: Glasgow scale (<>15), blood PLT level, and serum total protein level.
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PMC11271278
Source data are provided as a Source Data file.
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PMC9429973
E. M. Mahtat, H. MOUSSA BOUH, S. JENNANE, M. ABABOU, S. AHCHOUCH, A. HAMMANI, H. EL MAAROUFI, H. EDDOU, K. DOGHMI Clinical Hematology, Hôpital Militaire Mohamed V Rabat, Rabat, Morocco Background: Cytogenetics and molecular biology are the most important diagnostic tools for determining prognosis in acute myeloid leukemia (AML).
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PMC11661452
The image has been corrected and the figure updated. •
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PMC9429973
Scoring used an algorithm based on the International Myeloma Working Group (IMWG) frailty index: the final score is based on age (0 if ≤75 years, 1 if 76-80 years, 2 if >80 years), modified Charlson Comorbidity Index (CCI [Facon Blood Adv 2020]) (0 if CCI ≤1, 1 if CCI >1), and Eastern Cooperative Oncology Group performance status (ECOG PS) (0 if ECOG PS=0, 1 if ECOG PS=1, and 2 if ECOG PS=2).
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PMC11459296
This in vivo functionality and tumor infiltrating capacity of CB-MNCs prompts its application to study the in vivo interaction between immune cells, cancer cells and the TME and may serve as a platform for assessing cancer immunotherapies.
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PMC9429973
Patients on rux were more likely to have a negative T cell response than other patients (4/8 vs 20/22, p=0.0294).
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PMC11612626
Mouse studies were approved by the Institutional Animal Care and Use Committee.
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PMC11472639
indicates a significant difference from post-exercise at p < 0.05.
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PMC9429973
Median CD22-fluorescent intensity (CD22-FI) in NR as compared to R was 75.38 (IQR 59.58, 89.51) and 136.51 (IQR 114.38, 151.57) respectively, with significantly lower values in NR group (p = 0.04).
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PMC11173119
The primers used are listed in Table 2.
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PMC11731161
Primary CD138 cells were isolated from bone marrow aspirates of three multiple myeloma patients after obtaining informed consent.
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PMC11547917
To obtain a calibration curve, dilutions ranging from 0.5 mg/mL to 3 µg/mL were used.
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PMC11512230
The videos were processed with NTA 2.3 software version 2.3 build 0033 (NanoSight, Salisbury, UK).
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PMC11684269
Second, we outline the alterations in the renal microenvironment under certain kidney disease conditions.
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PMC11269933
The results of site mutations of CgERK1/2 and co-transfection with CgMAP2K1/2 proved that CgMAP2K1/2 can enhance PK enzyme activity by increasing the phosphorylation levels of T187 and Y189 in CgERK1/2.
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PMC10204952
For each cell line, the cells were cultured in 96-well plates with normal complete growth media, AD-CM with 10% FBS and CAA-CM with 10% FBS, respectively.
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PMC11655536
HD, healthy donor.
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PMC9429973
PFS outcomes in the naïve/exposed populations are comparable to those reported in TOURMALINE-MM1.
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PMC9429973
5 deaths occurred within 30d of study treatment; 1 patient with active CMML had an intracranial bleed with thrombocytopenia, possibly related to study treatment, while 4 deaths were attributed to underlying disease (3 with progression to AML, 1 MDS patient with sepsis).
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PMC9080589
Previous studies have shown that PCDHs play important roles in regulating multiple biological processes, such as cell proliferation, adhesion, cell cycle arrest, migration, apoptosis, dendrite arborization and neural development.
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PMC9118379
Variant spectra passing the PSM-level examination(s) will then proceed for examinations at variant peptide and event levels.
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PMC10092581
By analyzing the results obtained in Figure 2, we clearly observe that the cellular Se content is not in a 1 : 1 molar ratio with either metal content for all tested complexes; more particularly, the Se/Au ratio seem to be slightly more coherent than the Se/Ag one.
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PMC11773391
The apoptosis ratio was evaluated with the Annexin V‐FITC/PI Apoptosis Detection Kit (Signalway Antibody, College Park, MD, USA).
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PMC11612508
This indicates the successful transformation of graphite into GO, facilitated by adding oxygen-containing functional groups on the graphene sheets.
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PMC11337594
Once the cells reached 70% confluence, individual cells were selected by limited dilution and seeded in 96-well plates.
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PMC11185260
We further investigated whether the observed antitumor activity was associated with activation of cellular apoptosis.
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PMC11718274
Consistency with previous studies, the significant upregulation of the mitochondrial ND3 gene detected in Y2O3NPs treated A-431 cancer cells forced them to undergo apoptosis because this overexpression led to a shift from anaerobic glycolysis to aerobic respiration, depriving the cancer cells of glucose and thus inhibiting their proliferation.
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PMC11267830
Short hairpin RNA (shRNA) sequences targeting RBM39, THOC1 and EZH2 were encoded in pLKO.1-puro lentiviral vectors supplied by IGE Biotechnology Ltd. Guangzhou, China.
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PMC11723210
To address these challenges, we propose a novel biplane phase retrieval (BPR) method that integrates phase unwrapping results obtained at different propagation distances to achieve accurate absolute phase reconstruction.
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PMC11763126
In vivo imaging assessing lung metastasis levels.
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PMC10940855
Commensurate with these results, PB lambda light-chain levels were significantly lower in mice transplanted with dEFNB2-expressing multiple myeloma cells compared with mice transplanted with control multiple myeloma cells (Supplementary Fig. S6E).
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PMC9429973
The phase 2 portion of the study will initiate following the determination of the RP2D based on phase 1 results and is a single-arm, open-label study of GB5121 in subjects with R/R PCNSL.
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PMC10196713
Immunoreactive bands were visualized using ImmunoStar LD (FUJIFILM Wako Pure Chemical Corporation).
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PMC9429973
Mice were treated for 3 weeks (5 days on – 2 days off) with vehicle, dexamethasone (5mg/kg, IP), MRK-560 (15mg/kg, IP) or the combination.
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PMC11707832
Extensive evidence from diverse animal models further underlines the link between α-mannosidosis and CNS abnormalities.
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PMC11764090
AREB/ABF transcription factors regulate ABA-related gene expression and cold stress.
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PMC11467800
To determine and compare the invasiveness potential of the cells, we inoculated 100–200 stained K562 or K562‐IR cells separately into the yolk sac of 2 dpf larvae.
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PMC6163708
The next day (day 1), cell lines were treated with 10 μM GANT61 or 20 μM GANT61 (SelleckChem, München, Germany), for a maximum of 9 days.
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PMC9429973
High-risk cytogenetics is frequently observed in newly diagnosed myeloma with worsens outcome after single autologous, whereas a tandem autologous transplant strategy may overcome onset poor prognosis.
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PMC8864075
Venn diagram showed the intersection of 62 reTFAE and lung cancer targets (Figure 2A).
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PMC11469524
In addition, we also saw that CD40L stimulation in CA-46 cells could also produce hyperactivation of pERK together with p38 inhibition (S6 Fig).
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PMC11585254
A two-way ANOVA was used to compare the means between groups under different treatment conditions.
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PMC11381192
We subsequently constructed a nomogram by incorporating significant variables identified by the multivariate Cox analysis, including LDH, ALB, BMG and CSI, to estimate 2‐, 3‐ and 5‐year OS probabilities (Figure 5A).
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PMC9429973
Summary/Conclusion: These preliminary observations demonstrate the first link between low BDNF and bleeding tendency in GD.
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PMC7171147
Interestingly, DDR2 knockdown significantly abrogated COL11A1-induced FASN overexpression (Fig. 4B) while ITGA1 knockdown only slightly reduced FASN expression (data not shown), suggesting that DDR2 might be the predominant receptor that mediates COL11A1-induced FASN expression in ovarian cancer cells.
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PMC11730320
Average autosomal coverage was between 46-52X.
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PMC8540692
As reference standards, curcumin (purity > 99.5%), demethoxycurcumin (purity > 95.0%) and bisdemethoxycurcumin (purity > 98%) were used.
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PMC6442998
List of primers used is given in Supplementary Table 3.
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PMC6835428
Unfortunately, 0.5%PEIPOS/PTX/sicontrol was not tested; thus, the specificity of the siRNA remains undetermined.
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PMC5386478
However, the presence of hypoxic areas is a feature of cancer that can be exploited for designing rational therapeutic approaches.
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PMC11672142
All compounds were examined in the concentration range of 100 nM to 20 μM. Table 2 provides the inhibitory concentration of the compounds that results in 50% of the maximal cell count under no treatment conditions (IC50 values; a number not relative to the initial cell count).
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PMC7723249
For the transwell experiments, 10 cells per cm were seeded on a transwell cell culture polycarbonate-treated insert of 0.33cm2 diameter, 3μm-pore (Corning) in a volume of 200μl.
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