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OTAR3088
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BioData-CellLine_annotated

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PMC11783017
Before the right hind limb of mice was incised, iodophor was wiped to remove bacteria.
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PMC7057940
Proteins were digested with 100 µg/ml proteinase K for 2 h at 50°C, and the DNA was recovered by phenol/Chloroform extraction and ethanol precipitation using glycogen (20 µg/ml).
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PMC11782508
Ampicillin (10 mg/mL; Fisher Bioreagents) was used as a positive control, and sterile saline solution (0.9% w/v) served as a negative control.
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PMC11512230
To identify the localization of FITC-labeled AltMV SPV, we stained F-actin with rhodamine–phalloidin and nucleus with Hoechst 33342.
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PMC11740207
The first detailed description of healthy HSCs derived from long-term in vitro cultures was published in 1980, where they were referred to as long-term culture-initiating cells (Gartner and Kaplan, 1980).
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PMC10093184
In short, 2 × 10 of D-17 cells or 4 × 10 of COS4288 cells were seeded per well of a 96-well low attachment plate (96 w Brand plates U inert Grade clear, Brand GmbH, Wertheim, Germany) and cultivated for up to 21 days.
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PMC9504875
HAZV is an enveloped virus, and its genome consists of three segments of single-stranded, negative-sense RNA including S (small), M (medium), and L (large) genes .
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PMC9874064
NP-Pt-USP1i was supposed to cause DNA damage by released platinum drugs, i.e., cisplatin.
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PMC11155445
For a known quantity of Cu(acac)2, an increase in the concentration of acyl thiourea (163) and CHP improved flexural modulus of composites.
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PMC11612315
Moreover, our study revealed that GLP-1 analogs, including GLP-1, liraglutide, and exendin-4, along with the GLP-1 antagonist exendin 9–39, derived from exendin-4, which shares 53% sequence homology with native GLP-1, effectively inhibited CAP-induced TRPV1 activation in mouse DRG neurons.
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PMC9436459
M. yunanensis), M. multicaulis, M. nigra, and M. wittiorum Type E: Dehydroprenyldihydroflavone type MDAAs 14 compounds (114 − 127) distributed in seven species: M. alba, M. australis, M. lhou, M. macroura, M. mongolica (syn.
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PMC9429973
We selected the best-performing model and further established an application to predict 30-day mortality for ICH in adults with ITP.
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PMC3035438
The development of the hybridoma technology (1) has allowed the extensive selection and production of mAbs specifically binding to target antigens of interest, including several mAbs approved for clinical use against human diseases such as cancer (2).
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PMC11738017
The cells were washed, resuspended in cell staining buffer, and incubated with the respective secondary anti-immunoglobulin G subclass antibodies for 15 minutes at 4°C.
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PMC11266100
For the long-term transfection experiments, the luciferase-pcDNA3 plasmid was restricted with Bgl II enzyme.
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PMC7802142
Fluorescence images revealed the uptake of ReN-NV by DPCs in a time-dependent manner (Fig. 2a, b).
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PMC10713411
The robust predictive efficacy of this predictive model was also applicable in the E-MTAB-1980 and KIRP datasets.
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PMC11583010
H, Same as in G with tumor fragments from ovarian cancer PDX OV2423.
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PMC9780037
Nevertheless, it should be kept in mind that PEGylation of cyt c may affect its interaction with Apaf-1, which is a critical step in apoptosome formation.
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PMC9429973
No atrial fibrillation, tumor lysis syndrome or massive hemorrhage were reported.
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PMC9429973
Multivariate analysis showed that on HU, HbF and MCV were inverse independent significant risk factors for HBJ score>1 (p<0.001).
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PMC4839679
After discarding the fixative solution, wells were rinsed thoroughly with tap water and air dried.
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PMC7215832
Assuming that these conditions would also lead to specific promoter hypomethylation, we exposed A549 cells to increasing concentrations of RX-3117 and protein expression of MGMT and E-cadherin were evaluated.
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PMC8270637
NFATc1 directly targets the promoter regions of the PD-1 and CTLA-4 genes. (
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PMC11742231
Integrating drug fingerprints with SMILES enhances the models’ comprehensiveness and predictive power, resulting in more accurate drug efficacy predictions.
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PMC8414691
F Multinucleated cells (MC).
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PMC11705630
GLDC was first identified in non-small cell lung cancer as a factor critical to tumor initiation and overexpression of GLDC promotes cellular transformation and tumorigenesis 12, 35.
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PMC8623816
Nevertheless, repeated attempts were unsuccessful.
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PMC11659734
The EU‐FORA programme offered the fellow an opportunity to gain general information on different topics related to food safety risk assessment by attending the EU‐FORA dedicated training modules.
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PMC7369657
Fixed and permeabilized 143B cells were blocked with 1% BSA in PBS at room temperature for 1 h and then incubated with primary antibodies at 4°C overnight.
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PMC7724160
Measurements of metabolites in the solvent blank are also included in this dataset.
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PMC11301242
This absence enables rapid evolution of cancer cells, often leading to accelerated tumorigenesis and drug resistance [1,7,, , ].
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PMC10073922
Tumor Specific Promoters (TSPs), transcriptional regulatory elements that ensure targeted and efficient expression of genes in tumor cells, are key elements in the success of gene therapeutic approaches .
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PMC7081114
Growth of BEL-7404 cells detected by MTT assay after transfection with short hairpin RNA shCtrl or shKIF21B.
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PMC6450504
Here, we used a low-molecular-weight bPEI–lipid conjugate to engineer the liposome surface in attempts to develop novel nanocarrier formulations with improved stability and added functionality over non-PEGylated and PEGylated liposomes for a versatile nanomedicine platform.
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PMC11449273
For S100A4, we found that p53-175 significantly increased while p53-273 significantly decreased S100A4 transcripts level in H1299 cells relative to p53-WT.
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PMC11024707
After obtaining a blood sample in a plain or EDTA tube, it was mixed by gently turning it upside down 5−10 times.
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PMC10587429
Taken together, the engraftment of CD34 HSCs from fresh cord blood successfully induced robust and early reconstitution of human immune system with major subpopulations of immune cells in the NSG-SGM3 host.
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PMC9841531
Mean ± SEM values of at least three independent experiments are shown.
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PMC11781181
Labile iron pool (LIP) assay was measured by using calcein acetoxymethyl ester (Corning Inc., Corning, NY, USA) and iron chelator, deferoxamine (Abcam, Cambridge, UK).
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PMC11727306
Here, the effect of abrin toxin on the immune reaction was studied in human CD4 T-cell lines, and its inhibition of protein synthesis in kidney cells.
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PMC10728535
Downregulation of COL4A6 and EPHA3 genes was found in DEGs obtained in our study.
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PMC9429973
For pts from the NHL group who had MCL (n=17), ORR was 52.9% (95% CI, 27.8%-77.0%; CR 2; PR 7).
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PMC9429973
Median (range) of ratio was 1.24 (0-13), and ROC analysis with death as an endpoint identified 1.31 as the optimal cut-off value.
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PMC11310713
Cells were rinsed 3 times in DPBS before incubation for 1 h at RT with the goat anti-rabbit IgG H + L Alexa Fluor 488 secondary antibodies (Invitrogen, Waltham, MA, USA) diluted in 0.1% BSA in DPBS.
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PMC10955424
Additionally, based on our preliminary findings, it is advised to monitor tofacitinib's possible effectiveness in clinical settings in OC patients.
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PMC11753435
The cytosolic fractions were isolated from lysates using a Subcellular Protein Fractionation Kit (Thermo Fisher Scientific, 78840) per the manufacturer’s instructions.
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PMC6650823
A recent study demonstrates that the physiologically abundant SCFA pentanoate (C5) is a potent regulator of immunometabolism .
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PMC4485786
For comparison, normal cell cultures (black dot) show unimpeded proliferation (n = 3). (
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PMC11740207
The latter has opened up avenues for investigating leukemic and cancer SCs precursors in vitro, given the availability of experimental material in the form of cell cultures and the potential for efficient methods to enrich the number of primitive stages (Lica et al., 2018, 2021; Lica and Pradhan, 2023).
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PMC9429973
Because of its rapid progression and nonspecific clinical features, it is often misdiagnosed or discovered lately during the disease course.
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PMC9429973
Fewer study discontinuations were reported in the vaccinated versus the non-vaccinated group (n=1 vs n=21, Figure).
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PMC11687663
The study design with in-vitro and in-silico technique of the LC-MS followed by a study of the ligand–protein interaction using the molecular docking method, and investigates the cytotoxic activity by MTT assay of A. helferiana bioactive compounds on HepG2 cell lines.
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PMC9370419
Moreover, HBx also regulates the cccDNA transcriptional activity by preventing transcriptional repressor recruitment on the cccDNA, including SIRT1 and HDAC1 .
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PMC11653168
The translational significance of the present results is supported by the in vivo efficacy of Stattic in reducing tumor growth in a xenograft mouse model of T-ALL.
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PMC4485648
First, we analyzed the SFN effect on the HIF-1α mRNA level and found no significant difference between SFN-treated and control A2780 cells exposed to hypoxia, suggesting that SFN did not affect the transcription of the HIF-1α gene (Fig. 2A).
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PMC9429973
Summary/Conclusion: Long-term treatment with the oral PI, IXA, + LEN and DEX after an injectable PI-based treatment was tolerable and had favorable efficacy in patients with RRMM in the real-world setting.
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PMC11637820
Production of NO results in the creation of an aqueous by-product, nitrite, which is used as an indirect measure of NO using the Griess assay.
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PMC2777936
Testicular germ cell tumors (TGCTs) are classified as seminonas or non-seminomas of which a major subset is embryonal carcinoma (EC) that can differentiate into diverse tissues.
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PMC11730311
αCGRP8-37 binds to the CGRP-R and blocks binding by CGRP, thus acting as a competitive antagonist.
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PMC9019892
When tumour volumes reached 200–300mm, mice were divided into groups randomly and treated with drugs.
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PMC11727638
Thus, it is important to develop a 3D lymphoma model that better mimics the lymphoma microenvironment.
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PMC6461034
Detailed instructions are provided inside the script mqTMT_to_ppPeptide.
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PMC10820104
Genome sequencing indicated the formation of prenyltransferases, which was subsequently confirmed by the isolation of mono-, di-, tri-, and tetraprenylated compounds.
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PMC4659567
Half-sandwich organometallic ruthenium(II) complexes offer a broad scope for the design of therapeutic and diagnostic agents .
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PMC11737091
On the 41st day after inoculation, the mice were euthanised through the administration of 100% CO2 gas, with a flow rate of 30–70% of the chamber volume per minute.
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PMC9065483
Cell viability was measured by resazurin (Alamar blue) assay and expressed relative to untreated, uninfected cells. (
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PMC11394227
However, the VCD of CHO-PAb-QS cells was 9.1 × 10 cells/mL on day ten and 1.55 × 10 cells/mL on 12th day.
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PMC11718817
IL-18R-deficient CTLs (and, to a lesser degree, IL-1R-deficient T cells) have been shown to have enhanced velocity and more frequent arrests when moving through antigen-rich tumor environments.
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PMC9429973
Secondary endpoints (Phase 1a and Phase 1b, unless otherwise indicated) include PK/PD, objective response rate (Phase 1a), duration of response, disease control rate, progression-free survival, overall survival, and safety (Phase 1b).
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PMC11464982
IUBMB nomenclature Aspergillus nuclease S1 Systematic name–SynonymsEndonuclease S1 (Aspergillus); single‐stranded‐nucleate endonuclease; deoxyribonuclease S1 IUBMB NoEC 3.1.30.1CAS No37288‐25‐8EINECS No253‐443‐9 Aspergillus nucleases S1 catalyse the hydrolysis of ribonucleic acid (RNA) and single stranded deoxyribonucleic acid (DNA) to form monophosphate nucleotides with a strong specificity for the bases on the 5′ side of the RNA and DNA.
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PMC9429973
The cancer cell burden was monitored by intravital imaging.
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PMC11574029
Data are presented as the mean ± SEM of three independent experiments, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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PMC8735881
PPT.hPGK.WPRE).
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PMC9688728
Four metabolites from this small cluster are members of the fatty acids subclass.
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PMC7136814
Cells were harvested at the indicated time points, counted, and stained for intracellular markers.
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PMC9429973
All patients continued their chemotherapy in full doses (2/13 with minor delay).
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PMC9429973
Accordingly, patients are grouped as low risk (zero risk factor) disease, intermediate risk (one risk factor) and high risk (≥2 risk factors).
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PMC6379402
For our four cancers of interest and the four corresponding control tissues of origin, we considered all of iCell networks, PPI networks, COEX networks, and GI networks.
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PMC11180402
Our study also finds that DNMT3b plays a major role in regulating miR-129 promoter methylation upon ISO treatment.
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PMC11248911
Calcd.
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PMC11592837
Finally, however, the limitations of the present study must be mentioned: We believe that, in our time-course experiments, at later time points, a lower Jurkat cell concentration would have been more favorable for robust qPCR analysis on n-cfDNA.
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PMC11128598
Treatment with the HDACi LBH also produced an antiproliferative effect in the various tumor types analyzed, in agreement with previous reports (55).
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PMC11656380
First, we investigated the time course of cell death in Tat-Ram13- and etoposide-treated CCRF-CEM cells (Figure 5A).
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PMC11509309
In the course of our previous studies, several brominated tyrosine analogs with biological and ecological activities were discovered in the Oceanian marine sponges Suberea ianthelliformis , Suberea clavata , and Pseudoceratina sp. .
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PMC11687167
Therefore, PCSK9 might play an important role and might be an attractive target for investigating the complex immune response.
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PMC9429973
Cumulative incidence of any grade mucositis for Mel ≥ 3.28 mg/kg vs. Mel < 3.28 mg/kg was 33.5% vs. 29.1% (p=0.37) and of grade III mucositis was 12.1% vs. 24.0%.
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PMC9429973
Among index cases, 73 (82%) presented an hematological involvement.
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PMC9429973
For diagnostic or prognostic significance, level A: guidelines; B: expert consensus; C: small studies.
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PMC11591052
Moreover, although the anabolic activity of 20E has been widely recognized, the studies were limited to the 20E-mediated up-regulation of protein biosynthesis and the increase in the size of myofibrils, without delving into the molecular events underpinning these phenotypes .
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PMC10968586
All HT-dependent effects producing apoptosis as a result seemed to be mediated by protein phosphatase 2A (PP2A) .
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PMC11718274
Effective management of epidermoid skin cancer requires a comprehensive approach, including early detection, accurate diagnosis, and appropriate treatment.
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PMC11549612
Recognizing the potential for a favorable prognosis through early detection and surgical intervention, it becomes imperative to delve into the genomic alterations and inherent molecular mechanisms of KIRC.
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PMC7823217
On the other side, adenocarcinoma is found in cervical canal line close to column shaped glandular cells.
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PMC9792775
The results revealed that LFU enhanced the inhibitory effect of PTX on proliferation and was directly proportional to the treatment dose, which was listed in the Tables 1, 2.
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PMC7887261
TRICL Transdisciplinary Research in Cancer of the Lung, SNV single nucleotide variants, Indels insertion (ins)/deletion (del), LoF loss of function, fs frameshift, VUS variant of uncertain significance from ClinVar, NA not available, LC lung cancer, AD adenocarcinoma, FLC familiar lung cancer, OR odds ratio, CI confidence interval. #
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PMC11772449
Our study also confirmed this result.
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PMC11001582
n = 5 mice per genotype, one-way ANOVA, Bonferroni’s multiple comparison.
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PMC8494202
To confirm the impact of abnormally high expression of CKAP2L on the prognosis of glioma patients, we collected patient information from three different TCGA and CGGA transcriptome datasets and 40 clinical glioma patients.
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PMC10831439
Where stated, 10 µg/mL nivolumab (Novartis) or its IgG4 isotype control (BioLegend) were added to the assays.
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