PMCID string | Sentences string | ner list |
|---|---|---|
PMC11767793 | Optimized DMEM was provided by AddexBio (San Diego, CA, USA). | [
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PMC10114490 | diHLC-T, n = 6; HepG2, n = 3; *p < 0.05, **p < 0.01,***p < 0.005) Once determined the stability of diHLC-T with PD by HCS, we applied untargeted metabolomic analysis to establish their applicability for toxicometabolomic studies compared to HepG2, the most commonly used cell line in pharmaco-toxicological studies. | [
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PMC11790971 | c Example multimodal CHO cell images obtained from an artificial pool containing all four cell lines in passage 2. | [
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PMC11392912 | To measure Clo-miR-14, the total miRNA of Curcuma longa (200 ng) was mixed with 10 nM stem-loop primer (1µl), incubated at 60°C for 10 min for cDNA synthesis as per manufacturers guideline (QUIGEN, U.S.A.). | [
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PMC11739484 | In this study, employing a comprehensive methodology encompassing both in silico analyses and molecular experiments, we identified significant dysregulation of MMPs in SKCM, with MMP7, MMP11, and MMP14 emerging as key players linked to tumor progression, survival, and diagnostic potential. | [
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PMC11568601 | Afterwards, the cell apoptotic rate was calculated via a flow cytometry (BD Biosciences, CA, USA). | [
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PMC11342785 | F, quantification of synMAP circuit induction for the panel of TPPP-varying designs from (E), using the method described in Figure 5D. | [
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PMC9429973 | Methods: The clinical data, including the types of pathogenic microorganisms and their resistance profile to commonly used antibiotics, of patients developing bloodstream infection during hematopoietic stem cell transplantation from January 2020 to December 2021 were analyzed retrospectively. | [
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PMC9878278 | To further validate the association between the antiviral response against ZIKV infection and BMP6 signaling, we first tested if BMP6 expression is under the control of IFN-β in SC and two other cell types (A549 and BMVEC). | [
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PMC11708541 | 3-aminopyridine-2(1H)-one, acylates efficiently in CH2Cl2 in pyridine to form the chloroacetamide in a good yield. | [
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PMC11257988 | The difficulties in targeting KRAS are due to several factors: (1) the broad scope of KRAS’s activity, including its essential role in many normal cellular functions, meaning drugs that directly inhibit KRAS may have significant toxicity and strong side effects; (2) KRAS’s primary functional domain involves a pocket that binds to GDP or GTP. | [
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PMC7334607 | Finally, this work could be improved by examining how collateral drug response in EWS changes during relaxed selection after many drug cycles of the treatment regimen have been applied (Card et al., 2019). | [
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PMC11661040 | Fig. 5CGREF1 modulates osteosarcoma cell proliferation via the GSK3/β-catenin signaling pathway, and activation of the Wnt signaling pathway can counteract the impact of CGREF1 knockdown on osteosarcoma cells. ( | [
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PMC11658074 | The CK-MPA10 results revealed reduced melanin levels and improved elasticity in the fat graft group (Fig. 1f, g). | [
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PMC11787651 | A shorter gradient consisting of 5 to 30% B in 5 min with a total run time of 11 min was also selected as being suitable for the analysis of histone PTMs in applications that may prioritize time savings over maximizing the depth of information obtained, such as screens of large-batch cohorts or analyses concerning large changes in the distribution of histone PTMs. | [
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PMC11087055 | COS cells expressing either a control-GFP (control-GFP/COS) or Vg1 (Vg1/COS) construct were placed at the anterior marginal zone (AMZ) at pre-streak stage, approximately 180° from the posterior marginal zone where the authentic PS forms, and we analyzed the resulting cell flow during both authentic and ectopically induced PS extension (Figure 3B). | [
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PMC11643491 | The PVA films were dissolved in an isopropanol–water mixture (3:7 v/v) under moderate heat. | [
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PMC9429973 | Providing preparation and support for caregiver ambassadors was important. | [
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PMC9895440 | For the culture of HEK293T cells, DMEM (Sigma) was supplemented with 5% heat-inactivated (56 °C 30 min) fetal bovine serum (FBS, PAN Biotech), 100 ng/ml penicillin/streptomycin (Sigma), 2 mM L-Glutamine (Sigma), 1 mM Sodium Pyruvate (Sigma) and 1% MEM non-essential amino acids (Sigma) and 10 mM HEPES (Sigma). | [
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PMC11756514 | Green fluorescence protein (GFP) expressing S. aureus Reynolds (CP5), Reynolds (CP8), or Reynolds (CP-) were grown overnight at 37°C on Columbia agar with 2% (w/v) NaCl (CSA) or in suspension in Todd Hewitt broth (THB) at 37°C with shaking. | [
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PMC9031474 | Based on 9-epipolygodial (49), Wittig derivative 54 was synthesized leading to reduced cytotoxicity compared to 49 (Scheme 2) . | [
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PMC11185260 | Mice received total 6 injections of scL-SMARCB1 (30 μg/injection, twice weekly for 3 weeks, N = 7 for untreated group, N = 8 for scL-SMARCB1 group). ( | [
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PMC10366908 | LN229, mEGFR-overexpressed LN229 (LN229/mEGFR), and NMuMG were cultured in DMEM (Nacalai Tesque Inc.), supplemented as indicated above. | [
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PMC9599726 | TFRC staining was graded as negative (−), weakly positive (+), moderately positive (++), and strongly positive (+++). | [
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PMC11723947 | We also observed that the allogeneic T-cell response was characterized by the differentiation of a small proportion of IL-17A-producing cells (Fig. 2a, c). | [
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PMC4659567 | Herein we report the synthesis and characterization of the complexes of the general composition [Ru(η -p-cym)(naza)Cl2] (1–8; p-cym = p-cymene) containing 7-azaindole or its derivatives (naza). | [
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PMC11657744 | Data are reported as means ± SD of three independent experiments. | [
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PMC11543853 | However, distinguishing enterovirus virions from activated particles, both of which contain genomes, requires high-resolution information, since the two structures differ only in the details of their capsids (Supplementary Table 4). | [
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PMC11742290 | High LGR5 expression has been shown to be associated with increased tumor migration in cancers including gastric , CRC , breast , and HCC cancers. | [
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PMC2196094 | Fragments of sizes from 165 to 220 bp from the 3′ terminal end of the cDNA clones encoding RMCP-1 (R-I), RMCP-2 (R-II), RMCP-3 (R-III), RMCP-4 (R-IV), RMCP-6 (R-VI), and RMCP-7 (R-VII) were excised and inserted into the plasmid vectors pGEM-blue or pGEM-2. | [
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PMC11185260 | p<0.05. ( | [
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PMC8753818 | CHO-K1 and CHO-KO cells were maintained in RPMI medium supplemented with 10% fetal bovine serum as described previously . | [
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PMC11509309 | In order to determine whether the amount of PrP was modified by the treatment with the molecules, cell lysates (250 μg) were digested by 20 μg/mL of Proteinase K (PK, Thermo Fisher Scientific, #EO0491). | [
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PMC11467964 | Ultimately, we verified the eight BMRGs expressions in the novel signature, finding these signature genes had abnormal expression in STS, which indirectly confirmed the reliability of our analysis. | [
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PMC11089031 | Then, enzyme and buffer were added to the RNA mixture and ddH2O was added to makeup total volume to 20 μl. | [
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PMC11218145 | Twenty NOD-SCID mice pseudo-orthotopically inoculated with human MPM Ren cells were evaluated by BLI for tumour take rate and dimension, stratified into two groups of ten animals each and randomly assigned to treatment and control groups. | [
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PMC11655536 | Interestingly, lysosome was among the top 9 pathways in the KEGG analysis of the up-regulated genes (Fig. 3A). | [
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PMC11711347 | Molecular docking studies identified the active sites for the estradiol-estrogen receptor-α protein. | [
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PMC9429973 | Published data are scarce on this subject. | [
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PMC10728535 | Cisplatin serves as a highly effective chemotherapy drug for the treatment of a wide variety of cancers such as OC. | [
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PMC9429973 | S. Suma, M. Fujisawa, Y. Abe, Y. Suehara, D. Kaji, T. Sugio, K. Kato, K. Akashi, K. Matsue, N. Nakamura, A. Suzuki, Y. Suzuki, S. Chiba, M. Sakata-Yanagimoto Department of Hematology, Graduate School of Comprehensive Human Sciences; Department of Hematology, Faculty of Medicine, University of Tsukuba; Department of Hematology, University of Tsukuba Hospital, Tsukuba; Department of Hematology, Toranomon Hospital, Tokyo, Japan; Department of Medicine, Division of Oncology, Stanford University, Stanford, United States of America; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka; Division of Hematology/Oncology, Department of Internal Medicine, Kameda Medical Center, Kamogawa; Department of Pathology, Tokai University School of Medicine, Isehara; Department of Computational Biology and Medical Sciences, The University of Tokyo, Tokyo; Division of Advanced Hemato-Oncology, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Japan Background: Angioimmunoblastic T-cell lymphoma (AITL) and other nodal lymphomas of T follicular helper (TFH) cell origin (TFH lymphoma) are associated with immune dysregulation. | [
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PMC11026382 | We observed that R127A was more deleterious to catalytic function than Q33S, but that both mutations were more active than R166Q (which shows almost no measurable activity in vitro, Fig. 2b, Supplementary Table 3).Fig. | [
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PMC9910796 | This distribution resembles that of pEP84R when expressed individually, although with a more compact and perinuclear distribution. ( | [
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PMC9917080 | However, sorafenib in the nanocomplex with selenium, on the contrary, contributed to the induction of apoptosis. | [
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PMC7433824 | Therefore, we matched 9 and 32 unique genes in the U87 cell line with 100 µM P4 and 300 µM P4, respectively, with the differentially expressed proteins. | [
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PMC9429973 | Patient matched bone marrow and blood samples were obtained for each donor at three different time points across the course of the treatment. | [
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PMC9429973 | Haplo BMT was performed with PTCy. | [
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PMC10840195 | SPSS statistics software (version 23; IBM, Armonk, NY, USA) was used for statistical analysis. | [
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PMC11449273 | We show for the first time that plakoglobin differentially affected the oncogenic properties of p53-R273H and p53-R175H mutants expressed in the same cell line–H1299. | [
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PMC9844987 | Indeed, decomposition of multi-modal peaks within the CAGE TSS signals of promoters (Supplementary file 5) demonstrated that higher entropy reflects an increased number of decomposed promoters, as indicated by their number of local maxima of CAGE signals (Figure 4B). ( | [
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PMC10582049 | In fact, Grout et al. have assumed that the ADH1B subpopulation of CAFs acts as a transient form between normal fibroblasts and FAPaSMA CAFs. | [
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PMC11737091 | p < 0.05; **, p < 0.01; ***, p < 0.001 Knockdown of DBF4 expression blocked the cell cycle in ccRCC cells. ( | [
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PMC10204952 | A significant difference was defined by p < 0.05 compared to the vehicle control under different types of cell culture media series (*complete media, AD-CM and CAA-CM). | [
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PMC9429973 | T. Brandstoetter, B. Maurer, J. Schmoellerl, S. Kollmann, J. Huuhtanen, R. Grausenburger, S. Mustjoki, J. Zuber, V. Sexl Dept. | [
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PMC9105697 | Tumor detection occurs independently of the anatomic site, which is especially important for detection of extra-pulmonary metastases. | [
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PMC9587866 | The study was designed to gather potential inhibitors for the EYA3 target using medicinal compounds. | [
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PMC10291556 | This favors the new Pt–DCF complexes over the clinically used oxaliplatin in terms of their ability to induce ICD in cancer cells. | [
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PMC11704135 | Furthermore, another study investigating the antifungal activity of pyrimidine derivatives has demonstrated their inhibitory effects against Aspergillus flavus, A. fumigatus, Candida albicans, and Penicillium marneffei strains. | [
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PMC5941560 | Our WGS approach identified nearly 10x as many SNVs as were detected by COSMIC via microarray. | [
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PMC9429973 | they had an undetectable viral load and persistently low CD4 count (< 200 /mm3). | [
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PMC11514418 | APS is primarily sourced from Astragalus, which has the functions of tonifying Qi, consolidating the surface, strengthening the spleen, and benefiting the lungs and liver. | [
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PMC11680049 | Large accumulations of epiblasts were observed in both the central and peripheral regions of the callus tissue (Figure 7 and Figure 8). | [
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PMC7136814 | The protein expression of MYOD1 and Noggin genes in RD and A-204 cell lines were evaluated by flow cytometry to assess the distribution of these markers among the cell population. | [
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PMC10810426 | The same experiment was performed in BMDCs. | [
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PMC11637820 | The fast-halo assay was performed as previously described (23). | [
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PMC9966931 | Eugenol-derived molecules were ten-fold less toxic than thymol or carvacrol hybrids, and benzoic derivatives were slightly more active. | [
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PMC9100622 | After fixation with 4% formaldehyde solution, cell nuclei were stained with 0.2 µg/mL of DAPI and image acquisition was performed using the IN Cell 2200 automated wide-field microscopy system (GE Healthcare) at 10× magnification. | [
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PMC11188874 | If KO efficiency was <80%, a second round of sgRNA delivery is performed. | [
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PMC8956657 | A list of hydrogen-bonded interactions is presented in Supplementary Table 9. | [
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PMC11343332 | Gene expression analysis was performed using quantitative real-time PCR to determine the levels of proapoptotic and vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) genes mRNA expression. | [
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PMC7351993 | The probability of each scenario is given by the product of the probabilities of all the five parameters. | [
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PMC3765139 | The hybridization cocktail (130 μL) containing fragmented biotin-labeled target cRNA at a final concentration of 0.05 μg/μL was transferred into an Affymetrix Human Genome U133A 2.0 and incubated at 45°C on a rotator in a hybridization oven 640 (Affymetrix) for 16 h at 60 rpm. | [
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PMC10729469 | Table contains p-values for slopes and intercepts of Treg functions compared by linear regression analysis, n = 3. | [
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PMC10818573 | The RPA amplification products were subjected to agarose gel electrophoresis. | [
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PMC9429973 | The median age of patients was 60 years (interquartile range: 49-75 years). | [
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PMC10317042 | GO data are available in Supplementary Tables S3 and S4. | [
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PMC7081114 | Thus, silencing the expression of KIF21B inhibited cell proliferation. | [
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PMC11413393 | Figure (b) Created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license. | [
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PMC8345486 | A comparison of the IC50 values is shown in Figure 2A,B. In general, adenine nucleosides modified with metallacarboranes significantly decreased cell viability, regardless of cisplatin resistance. | [
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PMC11543853 | The duration of their exposure to those endosome conditions also differs. | [
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PMC11591038 | This evidence indicates the critical role of HIF-1 in AD patients with ApoE4. | [
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PMC11319300 | In the pre-B cells only, interactions between 19 and 22 months mice (“old mice”) were included (Koohy et al., 2018). | [
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PMC7334607 | In many cases, it is clear that ranking samples by their change in drug response also ranks them based on how long they have been exposed to the treatment regimen. | [
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PMC11798926 | Scale bar: 10 μm. | [
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PMC11422150 | In our experiments, a significant improvement was observed in three categories. | [
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PMC11201989 | Hh signaling is associated with increased levels of pathway mediators along the primary cilium including Gli2 and Gli3 . | [
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PMC11740399 | This indicated that 3025@ML exerts an antitumor effect by inducing apoptosis. | [
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"... |
PMC9429973 | These may have been otherwise undetected, but can subsequently be confirmed by FISH, and importantly allow the generation of molecular measurable residual disease (MRD) assays to assess treatment response. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC10820104 | This assignment was suggested from the molecular composition of 1 (C30H41N3O4), which, compared to rubrumline I (2) (C25H32N3O4), bears an additional isoprenyl group (-C5H9) constituting the last remaining degree of unsaturation. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC10840195 | The migration ability of cells was determined by a cell scratch experiment (B). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
"migration",
"ability",
"of",
"cells",
"was",
"determ... |
PMC11732523 | Zhisheng Chen: Data curation. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Zhisheng",
"Chen",
":",
"Data",
"curation",
"."
]
}
] |
PMC10938336 | A comprehensive analysis was carried out with the retrieval of 25,001 disease-related target predictions from the GenCard data set. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"A",
"comprehensive",
"analysis",
... |
PMC11774251 | Results are manifested as mean values accompanied by their standard deviations (±SD). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Results",
"are",
"manifested",
"as",
"mean",
"values",
"accompanied",
... |
PMC11237030 | Though, to our knowledge, no human AQP5 stable cell line is currently available. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Though",
",",
"to",
"our",
"knowledge",
",",
"no",
"h... |
PMC6268318 | The effectiveness of the plant extracts depended on the type of drug studied and the bioassay models. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
"effectiveness",
"of",
"the",
"plant",
... |
PMC9429973 | TK levels (p<0.001) and TPA (p<0.011) were also significantly higher in group 2 (7.7 and 49.8 IU/L) compared with patients in group 1 (4.2 and 34.3 IU/L). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC11521786 | All animal experiments were approved by the Center of Molecular Immunology’s Institutional Animal Care and Use Committee (CIM, Havana, Cuba). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tok... |
PMC10094992 | Once in the tumour tissue, the microenvironment cues are responsible for the polarization of tumour associated neutrophil (TAN) towards either anti-tumoural or pro-tumoural phenotypes . | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC11752740 | Our results indicate that the combination of pistachio hull extract and CFZ at the effective dose (ED50) produced notable synergy, with combination index (CI) values of 0.102 and 0.0221 for the SK-BR3 cell line at 24- and 48-hours, respectively. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC11576293 | 4H, Ar-H), 7.69 (s, 1H, pyrimidine–C5-H), 7.49 (m., 4H, Ar-H), 7.31 (m., 3H, Ar-H), 7.03 (d, 2H, Ar-H, J = 9 Hz), 4.6 (s, 2H, SCH2-), 3.91 (s, 3H, OCH3); C NMR (75 MHz, CDCl3) δ (ppm) = 171.9, 164.4, 163.3, 162.2, 138, 137, 135.4, 129.1, 128.9, 128.5, 127.1, 114.3, 107.1, 55.5, 35.5; HRMS (ESI+) calcd. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
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