OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9412887	Over all, the combination formulation strategy enabled multiple immunotherapy agents to be co-delivered to T lymphocytes and had the potential to strengthen immunotherapeutic effect by simultaneously inhibiting non-redundant inhibitory pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4443654	In common with previous studies , we observed good concordance of higher-order chromatin structure, reflected in Hi-C data, between different cell types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11783017	A, B) Representative fluorescence images and quantitative analysis of fluorescence signal intensity in mice after intravenous injection with Lipo and Lipo-IL11 (labeled with Cy5.5). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11155445	The activity of the compounds was found to a dose-dependent when incubated for 24 h, and IC50 values of the synthesized complexes were in the range of 8.6–12.4 μM against HeLa, MCF7 and A549 cells and selectively targeted cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11532793	Reducing the number of bootstrap or Gibbs resamples during transcript quantification will obviously reduce compute time but may might also adversely affect the statistical performance of downstream DTE methods.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11437637	Whereas the Th1/Th2 ratio was greater, indicating that cellular immunity was more dominant in patients with EC and that anti-infection and anti-tumor capacities were stronger .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11772449	At the same time, a mixture of protease inhibitors and phosphatase inhibitors was added to prevent protein degradation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "same", "time", ...
PMC6684588	P ≤ 0.01 vs. vehicle by unpaired t-test. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "≤", "0.01", "vs.", "vehicle", "by", "unpaired", "t-test", ".", "(" ] } ]
PMC11469524	This further indicates that the crosstalk is functional and inhibition of p38 leads to an enhanced ERK signaling output on a global scale.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...
PMC9429973	Methods: FIGARO (NCT03054181) was a European prospective, observational study in 14 sites.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "FIGARO", "(", "NCT03054181", ")", ...
PMC11471176	Subsequently, the % activity was calculated for each of the concentrations in one of two ways; either by dividing the slope of the fluorescence line for each measurement by the slope of the matching fluorescence line slope for enzyme control (% activity 1), or by dividing by the average slope for all the enzyme controls fluorescence lines (% activity 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803149	p <0.05, **p < 0.01. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", ",", "", "", "p", "<", "0.01", ".", "(" ] } ]
PMC11653533	However, the ethyl acetate extract of bark of F. microcarpa has shown noteworthy hepatoprotective activity by stabilizing the biochemical parameters like Serum Glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT), ALP, Total Bilirubin (TB), Direct Bilirubin (DB) and TP level in a dose-dependent manner, where, 200 mg extract showed SGOT, SGPT, ALP, TB, DB and TP values equal to 85.25 ± 2.81 IU/l, 59.07 ± 3.53 IU/l, 108.70 ± 8.35 IU/l, 0.46 ± 0.06 mg/dl, 0.27 ± 0.04 mg/dl and 5.16 ± 0.28 gm% respectively (Surana et al., 2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	M. Erlacher, F. Andresen, A. Yoshimi, M. Sukova, J. Stary, B. de Moerloose, M. Dworzak, S. Polychronopoulou, G. Göhring, C. Kratz, J. van der Werff ten Bosch, M. Seidel, B. Strahm, M. Wlodarski, C. Niemeyer Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Freiburg, Germany; Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czechia; Department of Pediatric Hematology-Oncology, Ghent University Hospital, Ghent, Belgium; Department of Pediatrics, St. Anna Children’s Hospital and Children’s Cancer Research Institute, Vienna, Austria; Department of Pediatric Hematology/Oncology, Aghia Sophia Children’s Hospital, Athens, Greece; Department of Human Genetics; Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany; Department of Pediatric Onco-Hematology, Universitair Ziekenhuis Brussels, Brussels, Belgium; Division of Pediatric Hemato-Oncology, Medical University Graz, Graz, Austria; Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany Background: Monosomy 7 is a non-random but poorly understood somatic event in myelodysplastic syndrome (MDS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11422497	After 5 weeks of feeding, the mice were euthanized, and nude mice were taken out to measure their size and weighed. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11718031	To understand this further, we have evaluated the amino acid levels during the process, and found that these differences can be attributed to the differences in the compositions of basal medium and feed at amino acid levels as shown in Fig. 6B which depicts the relative differences in amino acid composition among two marked groups in the Fig. 6A.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10669966	The slides were scanned with Pannoramic 250 Flash III (3DHISTECH) in the Biobank Helsinki and analyzed with a slide viewer (3DHISTECH).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11673902	A micropipette is a precision instrument for handling tiny volumes of liquid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "micropipette", "is", "a", "precision", "instrument", "for", "handling", "ti...
PMC11001582	c, Eye size of flies normalized to the mean of the control eye size.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", ",", "Eye", "size", "of", "flies", "normalized", ...
PMC11711127	In 2022, A study from Kersten et al. (167) demonstrated an extensive connection between the behaviour of tumour-associated macrophages (TAMs) and exhausted T cells within the tumour microenvironment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	The mechanisms behind this interconversion are still under investigation, but it is known that bone-marrow-derived cells (BMDCs) fuse spontaneously with several cell types like Purkinje neurons, cardiomyocytes and hepatocytes, creating heterokaryons.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8526701	Right, PUMA mRNA level was analyzed by real-time PCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Right", ",", "PUMA", "mRNA", "level", "was", "analyzed", "by", "real-time", "PCR", "." ...
PMC5330095	In brief, HepG2 2.2.15 cells are plated in 96-well microtiter plates.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "brief", ",", "HepG2", "2.2.15", "cells", "are", "plated", "in", ...
PMC10813895	This discovery implies that the age-dependent DNA methylation at the ELF5 locus might act as a preparatory factor for the development of luminal subtype BCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10728200	The results showed that the mitochondrial volume of GIST cells was reduced after IM treatment (Fig. 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "showed", "that"...
PMC11481779	To answer this question, we have taken a B cell derived cell line from a mouse , and tested our model on all the chromosomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Cell proliferation was determined by the Alamar Blue assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "proliferation", "was", "determined", "by", "the", "Alamar", "Blue", "assay", "." ] } ]
PMC10938336	Using annexin V-FITC/PI tests to analyze cell cycle arrest and cell death pathways, the apoptotic impact of compounds 2 and 4 on the HL-60 cell line was observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11733919	Then, membranes were incubated with a secondary antimouse antibody conjugated with HRP (5 μg/mL) in TBST with 1% (w/v) BSA at room temperature for 2 h. Afterward, 4 washes with TBST (5 min each) and one wash with TBS 1× were performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585254	Although CXCR5 has previously been shown to interact with β-arrestins (Kouzeli et al., 2020; Zhuo et al., 2022), the molecular determinants specifying β-arrestin recruitment and the functional outcome remain unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9727330	In contrast, the production level of both interleukins was dramatically reduced in treated cells with Asp and control-treated cells (Figure 5A and B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC3888431	Illumina reads were trimmed using the FASTX-toolkit with a minimum phred score of 15.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Illumina", "reads", "were", "trimmed", "using", "the", "FASTX-toolkit"...
PMC9454178	To analyse the differential CDK expression in GISTs, we obtained publicly available transcriptomic data of GSE136755 from the Gene Expression Omnibus (GEO), which includes gene microarray data and clinicopathological information for 59 primary GIST tumour samples without preoperative imatinib treatment .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10024132	In addition, γ9δ2 T cells have anti-tumor activity that is independent of PD-L1 expression level on tumor cells, which makes it more attractive than conventional αβ T cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11033180	The number of axonal intersections is increased in the presence of Sema5A-Fc as compared to control Fc without affecting the number of neurons per ganglion (D) (See also Figure S2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697065	D: Secreted IgG titre measured at D11.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", ":", "Secreted", "IgG", "titre", "measured", "at", "D11", "." ] } ]
PMC10944868	Figure 4 shows the results of the compounds synthesized in a boiled egg projection where the egg yolk corresponds to both the blood-brain barrier (BBB) and human gastrointestinal absorption (HIA) compounds and the egg white only to the HIA-positive compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8633974	J.H. and M.H. devised the experimental approaches; J.H, M.H., M.P., W.B., J.D.C, F.S. performed the experiments; B.D.K. and M.H. designed the synthesis and characterizations of the CRISPR LNPs and their use as an antiretroviral agent; B.D.K. and J.M. provided experimental guidance; J.H., M.H, and B.D.K. prepared figures, legends, and the manuscript; and H.E.G provided the overall project guidance, research infrastructure, scientific direction, funding, writing and review of the manuscript.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11529598	The LI-COR imaging system (LI-COR Biosciences) was used to detect fluorescein intensity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "LI-COR", "imaging", "system", "(", "LI-COR", "Biosciences", ...
PMC9429973	Results: A total of 160 patients were analyzed as the pooled pacritinib 200 mg BID group (n=106 in PERSIST-2; n=54 in PAC203) and 98 patients in the BAT group (44 on ruxolitinib).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8956657	This nuclear localization distinguishes ORF4b from other phosphodiesterase (PDE) proteins encoded by RNA viruses, such as the NS2 protein of betacoronaviruses within the subgenus Embecovirus, and VP3 of group A rotaviruses; both of which lack an NLS motif.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The trial CheckMate-436, including relapsed/refractory (rr) PMBL patients treated in at least 3 line with nivolumab and brentuximab vedotin (BV) showed an overall response rate (ORR) of 73% and complete response rate (CRR) of 43% (Zinzani et al. JCO 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10253553	As mentioned, hypoxia in the tumor microenvironment stimulates NDRG1 expression in cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "mentioned", ",", "hypoxia", "in", "the", "tumor", "microen...
PMC9429973	A. Srivastava, R. Kumari, S. Adhikari, P. Sergeev, J. J. Miettinen, M. H. Suvela, K. Flanagan, A. Slipicevic, N. N. Nupponen, F. Lehmann, C. Heckman Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Oncopeptides AB, Stockholm, Sweden Background: Immunoglobulin light-chain amyloidosis (AL) is a rare disease caused by plasma cell secretion of misfolded light chains that assemble as amyloid fibrils, which deposit on vital organs causing organ dysfunction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10958426	To measure cell similarity at CNV level, the inferred CNV level matrix was processed for chromosome arm weighted PCA and unsupervised clustering.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", ...
PMC7351993	When the particle of interest arrives at the sort point, the push-pull cell sorter is not activated because it is recognized as a nontarget particle, such that its position is maintained in the upper/lower side.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11258145	Due to the fact that in the human body, the membranes of different cells differ in their lipid composition, the effect of curcumin on each type of cell may be different.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10778532	The three different VHL mutated cell lines used in this study were generated in the laboratory of S. Richard (Gustave Roussy, Villejuif, France) and were already described .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9985266	Compared to the control group, α-SMA, FN, and COL I mRNA and protein expression were significantly higher after TGF-β1 induction, but IL-27 treatment significantly decreased the levels of α-SMA, FN, and COL I (Fig. 1B–E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11549612	Cell proliferation was assessed using the CCK-8 kit (Dojindo, Kumamoto, Japan) as per the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "proliferation",...
PMC10890055	We also used media with and without the G418 selection reagent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "used", "media", "with", "and", "without", "the", "G418", "selection", ...
PMC11741906	All reactions were run in triplicate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "reactions", "were", "run", "in", "triplicate", "." ] } ]
PMC11228511	Nuclear blebs form at sites of NM ruptures. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nuclear", "blebs", "form", "at", "sites", "of", "NM", "ruptures", ".", "(" ] } ]
PMC9429973	Intermediate-2 or high DIPSS risk was present in 48% of patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Intermediate-2", "or", "high", "DIPSS", "risk", "was", "present", "in", "48", ...
PMC10777969	The intensity of the color is proportional to the cell viability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "intensity", "of", "the", "color", "is", "proportional", "to", "the", "cell", ...
PMC11683240	The p-value for unpaired t test is reported as indicated, when lower than 0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "p-value", "for", "unpaired", "t", "test", "is", ...
PMC10291556	The H13 and H4 peaks are significantly merged for enDCF, whereas in the DCF spectra, the individual peaks are discernible.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "H13",...
PMC7812570	CEMss-CCR5 cells transduced with GPI-m36.4/GFP or GPI-FluIgG03/GFP were infected with 1,000 TCID50 of NL4-3 (A), SG3.1 (B), MJ4 (C), or RHPA.c/2635 (D), and intracellular HIV-1 P24 Gag and GFP expression was monitored over time by flow cytometry.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC10761571	The frequency of Lung cancer associated mortality has been increasing which indicates the inefficiency of current diagnosis and therapeutic approaches.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "frequency", "of", ...
PMC9545474	The complexes with triphenylphosphine‐3,3′,3′′‐trisulfonic acid and triphenylphosphine present similar cytotoxicity compared to the 16‐electron precursor, with equal cytotoxicity to both A2780 and A2780cisR. Hints at the mechanism of action suggest an apoptotic pathway based on reactive oxygen species (ROS) production.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11144200	n = 5, P < 0.01, *P < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "5", ",", "", "", "P", "<", ...
PMC10212663	After 24 h of transfection, the medium was changed and cultured at 37°C for another 72 h. Following puromycin screening (2 μg/mL), the RANKL gene knockdown and overexpression were validated by real‐time quantitative polymerase chain reaction analysis (qRT‐PCR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11799620	This attenuation is due to O. ficus indica fatty acids (Abdnim et al., 2024).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "attenuation", "is", "due", "to", "O...
PMC9872547	3-(4, 5- dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay results of nano-curcumin, curcumin, and nano-carrier treatments with different concentrations on the survival of the HeLa cell line are shown in Figure 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC11371627	Photograph.	[ { "tags": [ "O", "O" ], "tokens": [ "Photograph", "." ] } ]
PMC9429973	After a median follow-up of 27 months (mo) (8-40.5), the median OS for the entire cohort was 21.1 mo (Fig. 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656380	We investigated the inhibitory effect of Tat-Ram13 on the proliferation of human and mouse leukemia and lymphoma cells, as well as normal human peripheral blood mononuclear cells (PBMC) comprising lymphocytes and monocytes, and various adherent cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10936243	Orthopaedic surgery was also mentioned as a procedure in which bedding should only be used for those patients in severe pain and not for routine surgeries such as castration and OVH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11266100	G418 Sulphate (200 μg/mL; Carl Roth GmbH, Karlsruhe, Germany) was used to select transfected 4T1 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "G418", "Sulpha...
PMC9429973	Summary/Conclusion: National practice varies, including when to initiate pre-emptive Rituximab, with the most common threshold being 40,000 copies/ml.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":...
PMC11705067	Immune checkpoints were identified using the TISIDB database (http://cis.hku.hk/TISIDB/).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immune", "checkpoints", "were", "identified", "using", "the", "TISIDB", "database", "(", ...
PMC11695546	A slight elevation of antibacterial action towards H. pylori from 23.0 ± 0.1 to 28.2 ± 0.5 mm was displayed upon exposure of the coconut oil to ozone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10490530	Second, to ensure optimal performance in biotechnology and biomedical research applications, we prepared a humanized version of the Luz reporter and validated its performance improvements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8540611	A significant family among these proteins is bcl2, normally, this protein regulates mitochondrial activity, promotes the release of cytochrome C and the formation of reactive oxygen species (ROS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Grade 3 GI events occurred in 3, 0 and 1 patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Grade", "3", "GI", "events", "occurred", "in", "3", ",", "0", "and", ...
PMC11285179	After anti-angiogenesis therapy, tumor cells often experience a state of ischemia and hypoxia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "anti-angiogenesis", "therapy", ",", "tumor", "cells", "often"...
PMC11298021	Moreover, when used as a dual inhibitor along with rapamycin, miR-3143 and miR-3182 significantly increased apoptosis and caused cell cycle arrest in the Jurkat cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC11087055	See also Video 1 and Figure 1—source data 1. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "See", "also", "Video", "1", "and", "Figure", "1—source", "data", "1", ".", "(" ] } ]
PMC11763111	Data represent the mean ± SEM of triplicates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "represent", "the", "mean", "±", "SEM", "of", "triplicates", "." ] } ]
PMC11578343	Overall, we consistently observed that cells became less elastic (i.e., showed decreasing elastic G′) with increasing frequency for both Lat‐A and untreated control cells in the limited frequency range we measured (Figure S3A, Supporting Information).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9927933	By controlling the ubiquitylation and degradation of more than 80% of normal and abnormal intracellular proteins, the UPS regulates diverse aspects of cell physiologic and pathologic processes (1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In the past decade, in depth molecular profiling of LCH as well as other histiocytic neoplasms demonstrated that these diseases are fundamentally dependent on somatic MAPK activating mutations, with the canonical V600E BRAF mutation emerging in more than 50% of LCH patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6450504	In addition, various physicochemical properties of small molecule anticancer drugs and siRNAs make it very difficult to combine them and requires a versatile nanocarrier for successful applications (Krishna & Mayer, 1997, 2000; Pritchard et al., 2013; Abouzeid et al., 2014; Zuckerman & Davis 2015; Sarisozen et al., 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Some genetic abnormalities (BCR/ABL1, PML/RARa, AML1/ETO, CBFβ/MYH11 fusion genes) were detected by molecular genetic methods (FISH).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", ...
PMC9509578	Polymeric nanoparticles provide sustained release of drugs, prevent drug metabolism and detoxification and have a long circulation time, avoiding clearance from the system and enhancing uptake within cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11665186	In the article titled “Stem Cell Protein PIWIL2 Promotes EMT Process and Stem Cell-Like Properties in MCF7 Breast Cancer Cell Line”, published on pages 250, Issue 1, Volume 12 of Advanced Biomedical Research, the name of the author is written incorrectly as ‘Mohammad Emad Olya’ instead of ‘Arta Olya’.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", ...
PMC11683130	A heterozygous missense mutation of SerpinA1 occurs in patients with GPP (19).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "heterozygous", "missense", "mutation", "of", "SerpinA1", "occurs"...
PMC11787381	The formulation method was based on the film hydration method, followed by extrusion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "formulation", "method", "was", "based", "on", "the", "fil...
PMC10502403	The error bar shows the standard deviation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "error", "bar", "shows", "the", "standard", "deviation", "." ] } ]
PMC10530622	Glyoxal has been also described as a precursor of oxalate (for a review, see ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Glyoxal", "has", "been", "also", "described", ...
PMC11767817	We also measured the mitochondrial membrane potential using the ratiometric fluorescent probe 5,5,6,6′-tetrachloro-1,1′,3,3′ tetraethylbenzimidazoylcarbocyanine iodide (JC-1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "measured", "the", "mitoc...
PMC3734024	B cells were then harvested, washed in PBS, and cultured overnight at equivalent cell concentrations (7.5×10 viable cells/mL) in the presence or absence of stimulation with PMA and ionomycin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11082662	no. CTCC-400-0122; CCTCC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "no.", "CTCC-400", "-", "0122", ";", "CCTCC", ")", "." ] } ]
PMC11488203	In practice, this means that miR-dependent regulation is involved in various metabolic pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "practice", ",", "this", "means", "that", "miR-dependent", ...
PMC11387401	Because we relied on nRIPseq rather than the more demanding CLIP assay for the sake of throughput, we lacked the information on nucleotide enrichment in our dataset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	rituximab developed systemic hypersensitivity reactions but 2 patients had an injection site reaction (1 grade 1, 1 grade 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "rituximab", ...
PMC8632470	To each well of the microplate, 50 μL of diluted HEK293 cells (approximately 5 × 10 cells) was added.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", ...
PMC11473750	A 3D model of RNF121 was constructed using the AlphaFold DB website.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "3D", "model", "of", "RNF121", "was", "constructed", "using", "the", "...
PMC11453018	Results are presented as fold difference compared to control (untreated group at 48 hours) (n=3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "are", "presented", "as...
PMC9817179	Error bars represent standard errors.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "represent", "standard", "errors", "." ] } ]

PMC9412887

Over all, the combination formulation strategy enabled multiple immunotherapy agents to be co-delivered to T lymphocytes and had the potential to strengthen immunotherapeutic effect by simultaneously inhibiting non-redundant inhibitory pathways.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC4443654

In common with previous studies , we observed good concordance of higher-order chromatin structure, reflected in Hi-C data, between different cell types.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11783017

A, B) Representative fluorescence images and quantitative analysis of fluorescence signal intensity in mice after intravenous injection with Lipo and Lipo-IL11 (labeled with Cy5.5). (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11155445

The activity of the compounds was found to a dose-dependent when incubated for 24 h, and IC50 values of the synthesized complexes were in the range of 8.6–12.4 μM against HeLa, MCF7 and A549 cells and selectively targeted cancer cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11532793

Reducing the number of bootstrap or Gibbs resamples during transcript quantification will obviously reduce compute time but may might also adversely affect the statistical performance of downstream DTE methods.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11437637

Whereas the Th1/Th2 ratio was greater, indicating that cellular immunity was more dominant in patients with EC and that anti-infection and anti-tumor capacities were stronger .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11772449

At the same time, a mixture of protease inhibitors and phosphatase inhibitors was added to prevent protein degradation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "same", "time", ...

PMC6684588

P ≤ 0.01 vs. vehicle by unpaired t-test. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "≤", "0.01", "vs.", "vehicle", "by", "unpaired", "t-test", ".", "(" ] } ]

PMC11469524

This further indicates that the crosstalk is functional and inhibition of p38 leads to an enhanced ERK signaling output on a global scale.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...

PMC9429973

Methods: FIGARO (NCT03054181) was a European prospective, observational study in 14 sites.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "FIGARO", "(", "NCT03054181", ")", ...

PMC11471176

Subsequently, the % activity was calculated for each of the concentrations in one of two ways; either by dividing the slope of the fluorescence line for each measurement by the slope of the matching fluorescence line slope for enzyme control (% activity 1), or by dividing by the average slope for all the enzyme controls fluorescence lines (% activity 2).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11803149

p <0.05, **p < 0.01. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", ",", "*", "*", "p", "<", "0.01", ".", "(" ] } ]

PMC11653533

However, the ethyl acetate extract of bark of F. microcarpa has shown noteworthy hepatoprotective activity by stabilizing the biochemical parameters like Serum Glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT), ALP, Total Bilirubin (TB), Direct Bilirubin (DB) and TP level in a dose-dependent manner, where, 200 mg extract showed SGOT, SGPT, ALP, TB, DB and TP values equal to 85.25 ± 2.81 IU/l, 59.07 ± 3.53 IU/l, 108.70 ± 8.35 IU/l, 0.46 ± 0.06 mg/dl, 0.27 ± 0.04 mg/dl and 5.16 ± 0.28 gm% respectively (Surana et al., 2017).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

M. Erlacher, F. Andresen, A. Yoshimi, M. Sukova, J. Stary, B. de Moerloose, M. Dworzak, S. Polychronopoulou, G. Göhring, C. Kratz, J. van der Werff ten Bosch, M. Seidel, B. Strahm, M. Wlodarski, C. Niemeyer Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Freiburg, Germany; Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czechia; Department of Pediatric Hematology-Oncology, Ghent University Hospital, Ghent, Belgium; Department of Pediatrics, St. Anna Children’s Hospital and Children’s Cancer Research Institute, Vienna, Austria; Department of Pediatric Hematology/Oncology, Aghia Sophia Children’s Hospital, Athens, Greece; Department of Human Genetics; Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany; Department of Pediatric Onco-Hematology, Universitair Ziekenhuis Brussels, Brussels, Belgium; Division of Pediatric Hemato-Oncology, Medical University Graz, Graz, Austria; Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany Background: Monosomy 7 is a non-random but poorly understood somatic event in myelodysplastic syndrome (MDS).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11422497

After 5 weeks of feeding, the mice were euthanized, and nude mice were taken out to measure their size and weighed. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11718031

To understand this further, we have evaluated the amino acid levels during the process, and found that these differences can be attributed to the differences in the compositions of basal medium and feed at amino acid levels as shown in Fig. 6B which depicts the relative differences in amino acid composition among two marked groups in the Fig. 6A.Fig.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10669966

The slides were scanned with Pannoramic 250 Flash III (3DHISTECH) in the Biobank Helsinki and analyzed with a slide viewer (3DHISTECH).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11673902

A micropipette is a precision instrument for handling tiny volumes of liquid.

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PMC11001582

c, Eye size of flies normalized to the mean of the control eye size.

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PMC11711127

In 2022, A study from Kersten et al. (167) demonstrated an extensive connection between the behaviour of tumour-associated macrophages (TAMs) and exhausted T cells within the tumour microenvironment.

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PMC11599565

The mechanisms behind this interconversion are still under investigation, but it is known that bone-marrow-derived cells (BMDCs) fuse spontaneously with several cell types like Purkinje neurons, cardiomyocytes and hepatocytes, creating heterokaryons.

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PMC8526701

Right, PUMA mRNA level was analyzed by real-time PCR.

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PMC5330095

In brief, HepG2 2.2.15 cells are plated in 96-well microtiter plates.

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PMC10813895

This discovery implies that the age-dependent DNA methylation at the ELF5 locus might act as a preparatory factor for the development of luminal subtype BCs.

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PMC10728200

The results showed that the mitochondrial volume of GIST cells was reduced after IM treatment (Fig. 1C).

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PMC11481779

To answer this question, we have taken a B cell derived cell line from a mouse , and tested our model on all the chromosomes.

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PMC9429973

Cell proliferation was determined by the Alamar Blue assay.

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PMC10938336

Using annexin V-FITC/PI tests to analyze cell cycle arrest and cell death pathways, the apoptotic impact of compounds 2 and 4 on the HL-60 cell line was observed.

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PMC11733919

Then, membranes were incubated with a secondary antimouse antibody conjugated with HRP (5 μg/mL) in TBST with 1% (w/v) BSA at room temperature for 2 h. Afterward, 4 washes with TBST (5 min each) and one wash with TBS 1× were performed.

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PMC11585254

Although CXCR5 has previously been shown to interact with β-arrestins (Kouzeli et al., 2020; Zhuo et al., 2022), the molecular determinants specifying β-arrestin recruitment and the functional outcome remain unknown.

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PMC9727330

In contrast, the production level of both interleukins was dramatically reduced in treated cells with Asp and control-treated cells (Figure 5A and B).

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PMC3888431

Illumina reads were trimmed using the FASTX-toolkit with a minimum phred score of 15.

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PMC9454178

To analyse the differential CDK expression in GISTs, we obtained publicly available transcriptomic data of GSE136755 from the Gene Expression Omnibus (GEO), which includes gene microarray data and clinicopathological information for 59 primary GIST tumour samples without preoperative imatinib treatment .

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PMC10024132

In addition, γ9δ2 T cells have anti-tumor activity that is independent of PD-L1 expression level on tumor cells, which makes it more attractive than conventional αβ T cells .

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PMC11033180

The number of axonal intersections is increased in the presence of Sema5A-Fc as compared to control Fc without affecting the number of neurons per ganglion (D) (See also Figure S2).

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PMC11697065

D: Secreted IgG titre measured at D11.

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PMC10944868

Figure 4 shows the results of the compounds synthesized in a boiled egg projection where the egg yolk corresponds to both the blood-brain barrier (BBB) and human gastrointestinal absorption (HIA) compounds and the egg white only to the HIA-positive compounds.

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PMC8633974

J.H. and M.H. devised the experimental approaches; J.H, M.H., M.P., W.B., J.D.C, F.S. performed the experiments; B.D.K. and M.H. designed the synthesis and characterizations of the CRISPR LNPs and their use as an antiretroviral agent; B.D.K. and J.M. provided experimental guidance; J.H., M.H, and B.D.K. prepared figures, legends, and the manuscript; and H.E.G provided the overall project guidance, research infrastructure, scientific direction, funding, writing and review of the manuscript.

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PMC11529598

The LI-COR imaging system (LI-COR Biosciences) was used to detect fluorescein intensity.

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PMC9429973

Results: A total of 160 patients were analyzed as the pooled pacritinib 200 mg BID group (n=106 in PERSIST-2; n=54 in PAC203) and 98 patients in the BAT group (44 on ruxolitinib).

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PMC8956657

This nuclear localization distinguishes ORF4b from other phosphodiesterase (PDE) proteins encoded by RNA viruses, such as the NS2 protein of betacoronaviruses within the subgenus Embecovirus, and VP3 of group A rotaviruses; both of which lack an NLS motif.

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PMC9429973

The trial CheckMate-436, including relapsed/refractory (rr) PMBL patients treated in at least 3 line with nivolumab and brentuximab vedotin (BV) showed an overall response rate (ORR) of 73% and complete response rate (CRR) of 43% (Zinzani et al. JCO 2019).

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PMC10253553

As mentioned, hypoxia in the tumor microenvironment stimulates NDRG1 expression in cancer cells .

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PMC9429973

A. Srivastava, R. Kumari, S. Adhikari, P. Sergeev, J. J. Miettinen, M. H. Suvela, K. Flanagan, A. Slipicevic, N. N. Nupponen, F. Lehmann, C. Heckman Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Oncopeptides AB, Stockholm, Sweden Background: Immunoglobulin light-chain amyloidosis (AL) is a rare disease caused by plasma cell secretion of misfolded light chains that assemble as amyloid fibrils, which deposit on vital organs causing organ dysfunction.

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PMC10958426

To measure cell similarity at CNV level, the inferred CNV level matrix was processed for chromosome arm weighted PCA and unsupervised clustering.

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PMC7351993

When the particle of interest arrives at the sort point, the push-pull cell sorter is not activated because it is recognized as a nontarget particle, such that its position is maintained in the upper/lower side.

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PMC11258145

Due to the fact that in the human body, the membranes of different cells differ in their lipid composition, the effect of curcumin on each type of cell may be different.

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PMC10778532

The three different VHL mutated cell lines used in this study were generated in the laboratory of S. Richard (Gustave Roussy, Villejuif, France) and were already described .

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PMC9985266

Compared to the control group, α-SMA, FN, and COL I mRNA and protein expression were significantly higher after TGF-β1 induction, but IL-27 treatment significantly decreased the levels of α-SMA, FN, and COL I (Fig. 1B–E).

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PMC11549612

Cell proliferation was assessed using the CCK-8 kit (Dojindo, Kumamoto, Japan) as per the manufacturer’s instructions.

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PMC10890055

We also used media with and without the G418 selection reagent.

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PMC11741906

All reactions were run in triplicate.

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PMC11228511

Nuclear blebs form at sites of NM ruptures. (

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PMC9429973

Intermediate-2 or high DIPSS risk was present in 48% of patients.

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PMC10777969

The intensity of the color is proportional to the cell viability.

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PMC11683240

The p-value for unpaired t test is reported as indicated, when lower than 0.05.

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PMC10291556

The H13 and H4 peaks are significantly merged for enDCF, whereas in the DCF spectra, the individual peaks are discernible.

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PMC7812570

CEMss-CCR5 cells transduced with GPI-m36.4/GFP or GPI-FluIgG03/GFP were infected with 1,000 TCID50 of NL4-3 (A), SG3.1 (B), MJ4 (C), or RHPA.c/2635 (D), and intracellular HIV-1 P24 Gag and GFP expression was monitored over time by flow cytometry.

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PMC10761571

The frequency of Lung cancer associated mortality has been increasing which indicates the inefficiency of current diagnosis and therapeutic approaches.

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PMC9545474

The complexes with triphenylphosphine‐3,3′,3′′‐trisulfonic acid and triphenylphosphine present similar cytotoxicity compared to the 16‐electron precursor, with equal cytotoxicity to both A2780 and A2780cisR. Hints at the mechanism of action suggest an apoptotic pathway based on reactive oxygen species (ROS) production.

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PMC11144200

n = 5, **P < 0.01, ***P < 0.001.

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PMC10212663

After 24 h of transfection, the medium was changed and cultured at 37°C for another 72 h. Following puromycin screening (2 μg/mL), the RANKL gene knockdown and overexpression were validated by real‐time quantitative polymerase chain reaction analysis (qRT‐PCR).

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PMC11799620

This attenuation is due to O. ficus indica fatty acids (Abdnim et al., 2024).

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PMC9872547

3-(4, 5- dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay results of nano-curcumin, curcumin, and nano-carrier treatments with different concentrations on the survival of the HeLa cell line are shown in Figure 1.

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PMC11371627

Photograph.

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PMC9429973

After a median follow-up of 27 months (mo) (8-40.5), the median OS for the entire cohort was 21.1 mo (Fig. 1A).

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PMC11656380

We investigated the inhibitory effect of Tat-Ram13 on the proliferation of human and mouse leukemia and lymphoma cells, as well as normal human peripheral blood mononuclear cells (PBMC) comprising lymphocytes and monocytes, and various adherent cell lines.

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PMC10936243

Orthopaedic surgery was also mentioned as a procedure in which bedding should only be used for those patients in severe pain and not for routine surgeries such as castration and OVH.

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PMC11266100

G418 Sulphate (200 μg/mL; Carl Roth GmbH, Karlsruhe, Germany) was used to select transfected 4T1 cells.

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PMC9429973

Summary/Conclusion: National practice varies, including when to initiate pre-emptive Rituximab, with the most common threshold being 40,000 copies/ml.

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PMC11705067

Immune checkpoints were identified using the TISIDB database (http://cis.hku.hk/TISIDB/).

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PMC11695546

A slight elevation of antibacterial action towards H. pylori from 23.0 ± 0.1 to 28.2 ± 0.5 mm was displayed upon exposure of the coconut oil to ozone.

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PMC10490530

Second, to ensure optimal performance in biotechnology and biomedical research applications, we prepared a humanized version of the Luz reporter and validated its performance improvements.

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PMC8540611

A significant family among these proteins is bcl2, normally, this protein regulates mitochondrial activity, promotes the release of cytochrome C and the formation of reactive oxygen species (ROS).

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PMC9429973

Grade 3 GI events occurred in 3, 0 and 1 patients.

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PMC11285179

After anti-angiogenesis therapy, tumor cells often experience a state of ischemia and hypoxia.

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PMC11298021

Moreover, when used as a dual inhibitor along with rapamycin, miR-3143 and miR-3182 significantly increased apoptosis and caused cell cycle arrest in the Jurkat cell line.

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PMC11087055

See also Video 1 and Figure 1—source data 1. (

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PMC11763111

Data represent the mean ± SEM of triplicates.

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PMC11578343

Overall, we consistently observed that cells became less elastic (i.e., showed decreasing elastic G′) with increasing frequency for both Lat‐A and untreated control cells in the limited frequency range we measured (Figure S3A, Supporting Information).

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PMC9927933

By controlling the ubiquitylation and degradation of more than 80% of normal and abnormal intracellular proteins, the UPS regulates diverse aspects of cell physiologic and pathologic processes (1).

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PMC9429973

In the past decade, in depth molecular profiling of LCH as well as other histiocytic neoplasms demonstrated that these diseases are fundamentally dependent on somatic MAPK activating mutations, with the canonical V600E BRAF mutation emerging in more than 50% of LCH patients.

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PMC6450504

In addition, various physicochemical properties of small molecule anticancer drugs and siRNAs make it very difficult to combine them and requires a versatile nanocarrier for successful applications (Krishna & Mayer, 1997, 2000; Pritchard et al., 2013; Abouzeid et al., 2014; Zuckerman & Davis 2015; Sarisozen et al., 2016).

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PMC9429973

Some genetic abnormalities (BCR/ABL1, PML/RARa, AML1/ETO, CBFβ/MYH11 fusion genes) were detected by molecular genetic methods (FISH).

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PMC9509578

Polymeric nanoparticles provide sustained release of drugs, prevent drug metabolism and detoxification and have a long circulation time, avoiding clearance from the system and enhancing uptake within cells .

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PMC11665186

In the article titled “Stem Cell Protein PIWIL2 Promotes EMT Process and Stem Cell-Like Properties in MCF7 Breast Cancer Cell Line”, published on pages 250, Issue 1, Volume 12 of Advanced Biomedical Research, the name of the author is written incorrectly as ‘Mohammad Emad Olya’ instead of ‘Arta Olya’.

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PMC11683130

A heterozygous missense mutation of SerpinA1 occurs in patients with GPP (19).

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PMC11787381

The formulation method was based on the film hydration method, followed by extrusion.

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PMC10502403

The error bar shows the standard deviation.

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PMC10530622

Glyoxal has been also described as a precursor of oxalate (for a review, see ).

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PMC11767817

We also measured the mitochondrial membrane potential using the ratiometric fluorescent probe 5,5,6,6′-tetrachloro-1,1′,3,3′ tetraethylbenzimidazoylcarbocyanine iodide (JC-1).

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PMC3734024

B cells were then harvested, washed in PBS, and cultured overnight at equivalent cell concentrations (7.5×10 viable cells/mL) in the presence or absence of stimulation with PMA and ionomycin.

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PMC11082662

no. CTCC-400-0122; CCTCC).

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PMC11488203

In practice, this means that miR-dependent regulation is involved in various metabolic pathways.

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PMC11387401

Because we relied on nRIPseq rather than the more demanding CLIP assay for the sake of throughput, we lacked the information on nucleotide enrichment in our dataset.

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PMC9429973

rituximab developed systemic hypersensitivity reactions but 2 patients had an injection site reaction (1 grade 1, 1 grade 2).

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PMC8632470

To each well of the microplate, 50 μL of diluted HEK293 cells (approximately 5 × 10 cells) was added.

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PMC11473750

A 3D model of RNF121 was constructed using the AlphaFold DB website.

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PMC11453018

Results are presented as fold difference compared to control (untreated group at 48 hours) (n=3).

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PMC9817179

Error bars represent standard errors.

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