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PMC11476666
In contrast, no significant effect was observed in the RSV-treated cells when compared to the control or vehicle-treated samples.
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PMC11489351
MetaCore is a manually curated software that builds ontologies mapped to canonical pathways and networks.
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PMC11085211
In view of these considerations, the most active FR2-A subfractions (2A-35 and 2A-36) were mainly characterized by the presence of gallic acid, a phenolic acid which has been identified as a promising health-promoting agent in many conditions, including cancer .
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PMC11723947
Unexpectedly, our screen also reveals that T cells deficient for HP1γ or the methyltransferase SUV39H1 are better repressed by Treg than their wild-type counterparts.
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PMC11578343
mz‐visco‐NPS is also employed to measure the viscoelastic properties of human mammary epithelial cells across the entire continuum of epithelial transformation states, from average‐ and high‐risk primary epithelial cells, to immortal non‐malignant (MCF‐10A), malignant (MCF‐7), and metastatic (MDA‐MB‐231) cell lines.
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PMC11012313
Since multiple EBV latency proteins can influence HIF-1α expression , we tested whether the enhancement in HIF-1α in LMP2A-expressing lymphoblastoid cell lines was mTOR dependent.
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PMC11787355
Results were reported with 1% FDR at the peptide level.
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PMC11792766
No. 71‐102L), TA 1535 (Cat.
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PMC11731161
The nuclear accumulation of RanBP1 serves as a surrogate marker for XPO1 inhibition due to its widespread expression and rapid XPO1-dependent shuttling .
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PMC10743717
Furthermore, it is capable of binding to other proteins to carry out more physiological functions, such as mtRNA maturation .
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PMC11767725
Role of Hyperglycemia and Glucotoxicity : oChronic hyperglycemia exacerbates insulin resistance through glucotoxicity.oHigh glucose levels increase the mitochondrial production of reactive oxygen species (ROS), which damage IRS proteins and β-cells, further impairing insulin sensitivity and secretion.
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PMC10631132
MCND-TENS2, a peripheral blood mononuclear CD34/CD38 cell-derived iPSC line from a healthy donor (received from NIH National Heart Lung Blood Institute, Bethesda, MD, USA; registered at https://hpscreg.eu/cell-line/RTIBDi001-A) was compared to GM28404*B, a fibroblast-derived iPSC line documented to originate from “apparently healthy individuals” (received from Coriell Institute Cell Repository, Camden, NJ, USA; registered at https://www.cellosaurus.org/CVCL_C0M4).
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PMC11519567
A Schematic illustration for SS18-SSX onco-fusion in synovial sarcoma.
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PMC11680049
Understanding how the simultaneous biochemical and anatomical-morphological responses of Sequoia leaves regulate the changing hydrostatic potential with height can help resolve debates about the mechanisms that limit the maximum height of the tallest representatives of the plant world.
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PMC10565698
Only circUSP10 was amplified using both primer types in the presence of cDNA as a template (Fig. 1F).
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PMC11786156
All three EBV-positive DLBCL cases were positive for CD11a; two out of the three cases were positive for CD54, and one of the three cases showed discordant extra/intravascular expression of CD54.
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PMC11791203
Cancer encompasses a diverse group of diseases, each with distinct manifestations across the various tissues and cell types in the human body.
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PMC7823217
Hence, future research should also focus on the rapid and automated determination of cellular parameters including cell viability and cell cycle within the 3D construct in real-time.
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PMC11731161
Using CRISPR-Cas genome editing technology, Kwanten et al. identified E3 ubiquitin ligase ASB8 as a potential molecule affecting SEL sensitivity .
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PMC11684821
Second, we show that the MC.7.G5 TCR is cancer-specific, as it failed to respond to any of the many healthy cell lines tested in this study or our previous study (18).
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PMC11656048
Molecular docking and virtual screening were performed with AutoDock Vina software.
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PMC11609529
Future studies aimed at dissecting the role of YM nuclear condensates in tumor initiation, progression, and maintenance are crucial.
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PMC9429973
Aims: To investigate the influence of the radiotherapy history before CART cell therapy on the culture, expansion and treatment effect of CART cells in patients with aggressive B-cell lymphoma.
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PMC11680562
The particles were then dried in a hot-air oven at 120 °C for 12 h. The CuO NPs dried particles underwent calcination in a muffle furnace at 500 °C for 2 h (Fig. 1).Fig.
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PMC11748618
Imputed expression of CHD1L was compared for individuals with allelic combinations of rs59784663A-G, rs72999655-A-G, rs7525622-G-A, and rs73004025-C-T. Statistical significance was determined between allelic dosages using a Wilcoxon rank-sum test.
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PMC11676674
For the other molecules, we analyzed the retention time and pattern of fragmentation and used articles from the literature to have confirmation of our putative identification of the molecule.
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PMC8345486
Nevertheless, it can be expected that carborane compounds are poorly metabolized in the body, since no metabolites of carborane-modified biomolecules have been observed in serum by LC-MS and HPLC .
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PMC11629461
Immunocytochemical parameters.
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PMC11640115
Many reports have shown that the GPS/mGPS is an independent prognostic marker in various cancers .
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PMC10237474
Expi293F GnTIexpressed protein 7 showed nearly 100% purity in SDS-PAGE analysis, but there were 4% pre-peak and 10% of post-peak protein species detected by analytical SEC, accounting for the lower purity (Fig 5E, 5F and S3B Fig; Table 1).
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PMC11295144
For assessing the total expression of proteins, cells were permeabilized with 0.5% Triton X-100 (A16046, Alfa-Aesar) in HBSS for 10 min at room temperature before the blocking step.
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PMC11139449
The cultures were maintained in a humidified incubator at 37 °C with 5% CO2.
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PMC11578343
p‐values calculated using Wilcoxon rank‐sum test.
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PMC11683130
IL-17 is a major effector of psoriasis that activates the NF-κB signaling pathway (172).
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PMC11585254
A–B) Agonist-stimulated internalization of FLAG-CXCR5 in either WT HEK293 or β-arrestin1/2 DKO HEK293 cells (A) and DKO cells with empty vector (pcDNA) or β-arrestin1 and β-arrestin2 (+βarr1/2) re-expression (B).
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PMC11699178
This study, through the analysis of ovarian cancer single-cell RNA sequencing (scRNA-seq) data and transcriptome data post-GEM treatment, identifies the pivotal role of hypoxia-inducible factor 1 alpha (HIF-1α) in regulating the treatment process.
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PMC10969097
In their study, Zhang et al. successfully extracted a polysaccharide called MPSSS (577.2 KD) from Lentinula edodes mushroom.
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PMC11023271
B, C) 0.5% BSA induced down-regulation of PKK mRNA in HaCaT cells (B) or A431 cells (C), similar to FBE.
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PMC9429973
In Arm 2, venetoclax will be ramped up over 3 days to a target daily dose of 400 mg and azacitidine (75 mg/m) will be administered from D1–D7 or from D1–D5, and D8 and D9).
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PMC9454178
The qRT–PCR and immunoblotting analyses showed that OSR1 knockdown significantly inhibited c-KIT transcript and protein expression in GIST-T1 and GIST-882 cells (Fig. 8H, I).
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PMC11772585
I EdU staining assay was used to assess cell proliferation (n = 3).
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PMC5311252
Strikingly, in all three cell line models, EGFR inhibition using gefitinib resulted in a complete loss of colonies formed by miR-372 expressing cells, while only causing a modest decrease in colony size in parental and control cells.
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PMC9429973
The ORR was 100.0%, with 15 patients achieved CR and 1 patients achieved PR (R-CHOP in cycle 1 due to poor physical condition) after 3 cycles and all of them achieved CR after 6 cycles (Figure 1).
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PMC11209164
786-0 cells were pre-treated with TPF or DMF for four hours prior to infection with VSVΔ51-GFP at MOI of 0.05.
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PMC11348300
Each tumor type displays a unique response to palpation, while healthy tissue consistently exhibits similar responses.
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PMC11599565
Contrarily, in EpCAM cells this phenotype is rare to find (Panel D, E–H).
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PMC9429973
The survival without MMR loss was 61% and 41% in pts with 1st and 2nd TKI stop,respectively (Fig 1).
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PMC10926885
Dynein cytoplasmic heavy chain 1 has also been shown to be strongly linked to hepatocellular carcinoma's poor prognosis and immune infiltration.
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PMC11615828
Using light to manipulate synaptic vesicle transport in vivo.
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PMC10654497
A–D) Small ladder diagram comparing patients with C1 and C2 subtypes regarding the three immune scores and tumor purity. (
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PMC11469524
Changes in the phosphorylation of MEK and ERK in BL-2 cells after treatment with α-IgM in the presence or absence of the p38 inhibitor SB203580. (
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PMC11786767
In contrast, fewer cells were at metaphase upon RO-3306 treatment (Fig. 8C).
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PMC11721064
scale bar = 50 μm) The molecular expression patterns in the skin and cornea.
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PMC10154881
The cell viability was determined using a Premix WST‐1 Cell Proliferation Assay System (TaKaRa) at the indicated time points.
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PMC11391695
QRT-PCR analyses further verified that the expression of ACYP2 was drastically downregulated (p < 0.001) in HCC tissues relative to the adjacent normal tissues, whereas the expression of YTHDF2 was marginally overexpressed (p < 0.05).
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PMC11544122
Data were normalized to endocytosis in parental cells.
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PMC11286266
Lower panel: Calibration curve derived from known quantities of purified rCRT, fitted to a linear function.
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PMC8170755
The interaction between Nm23-H1 and MMP-9 is controversial.
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PMC11730320
B cells, NK cells, and neutrophils were also normal, while monocytes were normal/borderline low (Fig. 3D–G).
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PMC11063646
Through a combination of in-vivo and ex-vivo experiments, a substantial amount of the drug was observed to be retained in the dermal and epidermal layers for a duration of up to 24 h. This extended retention explains the localization of andrographolide within the dermis and epidermis layers (Khan et al., 2023).
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PMC11805741
Historically, natural products (NPs) of plants or microbial origins have played a critical role in treating different health problems, especially cancer and infectious disorders.
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PMC11391695
For the cell proliferation assay, the CCK-8 reagent (MedChemExpress, Shanghai, China) was utilized.
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PMC11724582
Almonertinib, the first domestically developed third-generation EGFR-TKI, was approved for listing in March 2020 and is currently being used clinically .
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PMC9429973
Oral treatment of mice with recombinant hBD-2 post allo-HCT reduced weight loss and acute GVHD severity and mortality.
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PMC11607321
Additionally, Gaussian distribution was set for the dist_block hyperparameter for both the transcriptomic and drug response data.
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PMC10547921
Lerchen et al. further illustrates the degree of modification allowed in the C-terminal binding domain of auristatin.
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PMC11267830
To highlight the critical function of DCAF15 in the mechanism of action of indisulam against T-ALL, we employed CRISPR-Cas9 technology to generate DCAF15-null variants in both the J. gamma1 and Jurkat cell models.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594806
Tumor-infiltrating lymphocytes and PD-1/PD-L1 axis engagement were analyzed through multiplex immunofluorescence staining .
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PMC11754291
While this difference was statistically significant (p < 0.05), it suggests only a minimal reduction in cellular metabolic activity in keratinocytes, indicating almost no cytotoxicity.
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PMC10125312
Additionally, cell size and exocytosis rate also have a role on cellular uptake and photothermal heating.
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PMC11638288
The mechanism involves an elevated presence of NKp46 NK cells in the intestinal mucosa of CD patients.
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PMC11592008
Pro-IL-1β expression decreased in PKs upon talabostat treatment, which was not observed in the other analyzed cells (Figure 3A–D).
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PMC11680562
Wells were created in the agar plates using an 8-mm cork.
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PMC11683240
Consequently, PT is considered a promising focus for creating innovative therapeutic approaches.
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PMC6461034
The publicly available 11‐plex TMT dataset PXD009477 of ALK signaling in the neuroblastoma cell line NB1 (Emdal et al, 2018) was re‐analyzed using INKA.
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PMC11574271
The average levels of miR-659-3p expressed by cancer cells were significantly reduced in comparison with those from normal tissues (Fig. 6A).
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PMC11774747
Similarly, CD28 co-stimulation appeared crucial for optimal expansion and function of VST transduced with a different CAR (CD19.CAR).
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PMC9429973
Stratified Cox models allowing for effect modification between sex and treatment and adjusted for stage, age at diagnosis, year of diagnosis, parity, and performance status were used to estimate hazard ratios (HRs).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Yet, while healthy donors’ derived exosomes carry only the wild type JAK2 mRNA, we detected both the wild type and the mutated JAK2 isoforms in patients with PV.
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PMC11092382
Pharmacological effects of sophocarpine In Chinese medicine, traditional herbal formulas consist of combinations of various herbs that contain multiple active ingredients that work synergistically to exert therapeutic effects.
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PMC11470381
The multichannel 2D time hyperstack was split into two time-lapse videos corresponding to actin-GFP (green) and Piezo1 mCherry (red).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11766174
TACK compounds are non-nucleoside reverse transcriptase inhibitors (NNRTIs) that can induce HIV-selective cytotoxicity through binding to the RT domain of monomeric Gag-Pol and causing premature intracellular viral protease activation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767817
We found that the Akt signaling pathway may modulate the activity of compound 2a-B, as evidenced by enhanced cytotoxic activity in combination with MK-2206, an Akt 1/2/3 inhibitor.
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PMC11092382
They conducted a study to assess the transdermal parameters of the four main alkaloids (matrine, oxymatrine, sophocarpine and oxysophocarpine) in Kushen recipe.
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PMC9429973
Results: We included 196 pts (118 pre-HTN and 78 de novo HTN) from 12 centers.
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PMC11748363
A full description of the methods can be found in Data S1.
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PMC9429973
All statistical analysis was completed on STATAv16.1.
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PMC6643347
A 15- and 19-fold higher concentration was required to achieve the same extent of inhibition in dendritic cells infected with the same strain.
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PMC8903741
According to the merits of CHO cell-based antibody generation system, including stable producing of antibody with high yield, we herein established a novel CHO cell line for producing recombinant antibody against hMMP and showed its antigen-binding efficiency.
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PMC8740518
Correlation pattern among measured metabolites over the entire cohort using pearson correlation. (
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PMC10024132
Adherent Hep-3B hepatoma cells and HEK-293 kidney cells were transfected with a CD19-encoding DNA and then used as target cells.
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PMC10847511
However, it should be noted that most of these experiments examined the association between dysfunction of BRCA molecules and in vitro drug sensitivity in cells with identical backgrounds.
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PMC6268318
Meanwhile, embryotoxic effects have not been reported (Table 1).
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PMC9429973
Summary/Conclusion: Anti-GPIIb/IIIa antibody is a sign of higher severity in newly diagnosed pediatric ITP.
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PMC11694346
The solvent was then evaporated, and the residue underwent vacuum drying for 15 hours.
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PMC11409031
The PCR amplification conditions consisted of 45 cycles: 10 min at 94 °C, then 10 s at 94 °C and 45 s at 60 °C.
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PMC11637820
Plates were incubated overnight at 37°C and then photographed using a digital transilluminator.
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PMC11092382
However, there is currently no research validating the efficacy of either sophocarpine or matrine alone in combating E. granulosus infection.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "t...
PMC6160470
Overall, the results obtained in UIC2 shift and ATPase assays indicate that crown ethers are probably not P-gp substrates.
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PMC10891340
A–C) DEF cells were infected with DPV-GFP at dose 1 MOI for 1 h, then cells were treated with different concentrations of CCCP, and DMSO was added as control.
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