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PMC10831439
CD19-directed CAR-iNKT cells induce cell death of CD19+ cell lines and primary patient cells. (
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PMC10335954
Previous studies have shown that p53 as the caretaker gene can halt cell cycle and induce apoptosis in response to acute DNA damage (Bieging et al. 2014; Lane and Levine 2010).
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PMC4839679
A major caveat, however, is that ccRCC is a heterogeneous cancer characterized by a metabolic shift but not absolutely defined by a particular mutation or set of mutations.
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PMC11682172
In all statistical analyses, a p-value < 0.05 was considered statistically significant.
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PMC11240448
This can be explained by negative feedback connections within the RAS-RAF-MEK-ERK cascade.
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PMC11247842
a Manhattan plot for clinical mastitis .
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PMC11281366
For instance, the upregulation of miRNAs-221/222 inhibits HIV-1 infection by downregulating the virus primary CD4 receptor in lymphocytes, as well as in monocyte-derived macrophages (MDMs) .
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PMC11621493
Auto-MS/MS mode was used for MS/MS analyses with three spectra per second, precursor absolute threshold of 200 counts, and fixed collision energy of 25 V. Quality control samples were analyzed using iterative acquisition mode to increase the number of MS/MS spectra for improved lipid annotation.
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PMC9429973
Intrasplenic blood was enriched in RBC displaying a peripheral fluorescent dot, highly suggestive of ongoing intrasplenic expulsion of vacuoles (pitting).
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PMC11705862
Each group consists of n = 3 cases).
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PMC10729469
Mouse T cell activating CD3/CD28 Dynabeads (Catalog no. 11456D, Thermo Fisher Scientific) were added to each well at a bead:Tresp ratio of 1:1 to induce Tresp proliferation.
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PMC11514418
It was also revealed that APS markedly activated peritoneal macrophages, increased TNF production, and induced the proliferation of LAK-like cytotoxic cells, thus resisting 12 rapidly proliferating tumor cell lines in vitro.
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PMC9509578
Alsaab et al. reported co-delivery of sorafenib and CA IX-C4.16 by TPGS nanoparticles in multidrug-resistant cancer cells to overcome hypoxia-mediated MDR.
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PMC8922418
As HIV-1 enters immune cells through co-receptors CCR5 and CXCR4, the most effective method is using gene-editing technology to silent or mutate co-receptors and confer cell resistance against HIV-1 infection. (
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PMC10440586
We observed that CD99 was also overexpressed in these cell states and negatively correlated with cell stemness (Supplementary Figure 1E and 1F).
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PMC9429973
Targeting a signalling pathway that is altered in all LSCs could be a novel, promising treatment strategy.
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PMC8494202
We further validated the influence of CKAP2L on patients with glioma by analyzing 40 clinical samples, consisting of both high-and low-grade glioma tissues, and the patient characteristics and outcomes.
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PMC11697065
Foxm1 is a transcription factor expressed in actively dividing cells and is critical for cellular functions such as proliferation and cell cycle progression .
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PMC9429973
Patients who had received prior anti-BCMA treatment were ineligible.
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PMC9429973
For MDSC differentiation, BM was isolated from naïve mice.
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PMC9429973
We have recently shown in cell lines a potential therapeutic role for NUC-7738 in patients with acute myeloid leukemia (AML), whereby NUC-7738 induced myeloid cell differentiation and mitochondrial-mediated apoptosis.
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PMC11673902
Although biochemical markers have a broad base of applications, biophysical markers, such as the mechanical properties of cells, still show unique advantages.
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PMC11790971
Four industrially relevant mAb-producing CHO cell lines with varying production phenotypes were imaged during early passages (i.e., passage 0, passage 1, and passage 2).
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PMC11190538
Like other pigments, such as phycoerythrin, C-PC is categorized as a phycobiliprotein (PBP).
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PMC9429973
After 14 days, organoids engrafted with myelofibrosis but not healthy cells showed dramatic fibrotic remodelling (Fig 1C).
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PMC9429973
Our data suggest that blinatumomab should be preferably used in consolidation rather than as salvage therapy in patients with B-ALL in first relapse T. Vaid, R. Dhawan, M. Aggarwal, P. Kumar, J. Dass, G. VIswanathan, T. Seth, S. Tyagi, M. Mahapatra Hematology, All India Institute of Medical Sciences, Delhi, India Background: Improvement in supportive care, introduction of more intensive chemotherapy regimens and strategic use of allogenic stem cell transplant in some patients has resulted in significant improvement in outcomes of patients with acute lymphoblastic leukemia (ALL).
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PMC10926885
Co‐immunoprecipitation detected the interaction between NDE1 and DCTN1 in T24 cells.
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PMC11519077
Caco2 was employed from a human colon adenocarcinoma (RRID: CVCL_0025), which was obtained from the Pasteur Institute (Tehran, Iran) and cultivated in DMEM with 10% (v/v) fetal bovine serum (FBS) (Gibco, Grand Island, United States) and 1% (v/v) penicillin/streptomycin (Pen/Strep) (Gibco, Grand Island, United States).
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PMC5308810
The specificity of CXCR4-KLA was confirmed by a reduction of the CXCR4 fraction of both CXCR4 and A2780/ADR after treatment with a suboptimal concentration (2 μM) of CXCR4-KLA for 72 h. (D) CXCR4-KLA is more potent than the conventional CXCR4 antagonists, including AMD3100 and CTCE9908, toward A2780, A2780/ADR, and SKOV3.
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PMC9429973
Summary/Conclusion: LF/IFPRLR is a safe and isoform-specific prophylactic and therapeutic target to alleviate pathology of B cell subsets and concurrently lower the incidence of B cell malignancies in SLE patients (Stage 1), reduce the risk of B cell malignancies in people with pre-malignant and indolent B cell clones (Stage 2), and treat overt B cell neoplasms (Stage 3).
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PMC11487720
Cells were seeded onto 96-well plates overnight, and then MTT was added for incubation at 37℃ for 4 h, then decanting the culture supernatants and adding 100 μL DMSO to dissolve the MTT-derived formazan purple crystals.
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PMC11739484
Time-lapse analysis of wound healing over 24 hours.
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PMC7039683
Differentiation of the zebrafish EVL also depends on Grhl paralogs, Klf17, and simple-epithelium keratins (e.g., Cyt1, Krt4, Krt8, Krt18) (de la Garza et al., 2013; Liu et al., 2016; Pei et al., 2007; Miles et al., 2017).
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PMC11755467
Therefore, discovering novel therapeutic strategies remains an urgent need.
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PMC11348300
While certain tumors appear well oxygenated under normal conditions, their vasculature is chaotic, and slight pressure or stress can trigger prolonged transient hypoxia.
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PMC11496728
The 2 method was used to calculate the copy number in each sample.
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PMC11487720
The reduction of caspase 3 may account for the failure of BCD-induced internucleosomal DNA fragmentation at room temperature or 4 °C (Fig. 5B).
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PMC11742047
For the quantification of proteins, cells were washed with cold PBS and proteins were extracted using RIPA buffer.
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PMC9792775
Effect of treatment with LFU + PTX on apoptosis of A-204/HT-1080 cells. (
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PMC11575040
A Venn diagram depicting the identification process of miR-1270, which was found to interact with LINC00094 through TargetScan prediction and to be upregulated in cells with LINC00094 knockdown along with si-LINC00094-2 and si-LINC00094-3 transfection through small RNA profiling.
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PMC6934009
In consistence with the reported activity of flavonoid compounds, these molecules showed radical-quenching potential, anti-oxidant activity, and anti-tumor property (10).
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PMC4443654
Chromatin boundaries, separating TADs and nuclear compartments at different scales, also showed cell-type-specific enrichments of various locus-level chromatin features.
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PMC9341513
Nevertheless, they provide insight.
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PMC11519583
To assess the proportion of Ror2-positive cells within the total MP population, we conducted fluorescence in situ hybridization analysis.
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PMC6102174
Oxymatrine has been used to treat hepatitis B in clinic with confirmed efficiency and safety, and its target is host Hsc70 instead of viral polymerase.
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PMC11754432
Elevated phosphorylation of STAT1 in comparison to total STAT1 was observed with ALOX15B silencing, along with elevated total STAT1 in comparison to total protein (Fig. 3A).Fig.
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PMC11488203
Physiological functions of MSC include repair and regenerative activities and various clinical studies are using MSC to treat hematological diseases, graft-versus-host disease, organ transplantation, diabetes, inflammatory diseases, bone and cartilage, neurological, and skin diseases, among others [5–8].
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PMC11657744
Unless otherwise stated, all statistical analyses were conducted using GraphPad Prism.
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PMC11488203
n = 3) Effects of MSC taxol exosomes on breast cancer cells as compared to normal breast epithelial cells.
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PMC7369657
In apoptotic cells, JC-10 localizes as a monomer exhibiting green fluorescence .
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PMC8557138
Studies have demonstrated independent mechanisms inducing angiogenesis in tumors such as (a) HIF-1/VEGF mediated paracrine interactions between a cancer cell and endothelial cells, (b) recruitment of progenitor endothelial cells, and (c) vasculogenic mimicry.
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PMC11727062
In vitro, HHT induces apoptosis in melanoma A375 cells.
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PMC11656380
These data indicate that caspase activation is not involved in the cell death mechanism induced by Tat-Ram13, suggesting that the mode of Tat-Ram13-induced cell death is nonapoptotic.
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PMC9960565
In more detail, several generations of anionic PAMAM dendrimers (the half generations G0.5 to G3.5) were functionalized, with cisplatin in mono- and bidentate forms and characterized with nuclear magnetic resonance spectroscopy (NMR), mass spectrometry (MS), Fourier-transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-Vis), and fluorescence spectroscopy.
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PMC8864075
CT values were used to evaluate the relative mRNA expression by 2 method and β-Actin served as an internal control.
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PMC11770746
Experiment protocol consisted of a series of three injections (days 1, 3, 5) of saline (control), cisplatin (3 mg/kg), oxaliplatin (4 mg/kg), paclitaxel (8.5 mg/kg), cisplatin & paclitaxel mixture (3 + 8.5 mg/kg), and platinum(IV) complexes dosages were adjusted to Pt amount—Cis(OAc)2 (4.16 mg/kg), Oxali(OAc)2 (5.19 mg/kg), and Cis(Paclitaxel)(OH) (12 mg/kg).
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PMC8735881
After three washes with TBS-Tween 20, the membrane was incubated with IRDye 680LT goat-anti-rabbit IgG, IRDye 680LT goat-anti-mouse IgG, or IRDye 800CW goat-anti-human IgG for 2 h at room temperature.
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PMC10858941
In this study we sought to examine the effects of NNC-55-0396, a tetralol compound which overactivates the unfolded protein response inducing apoptosis, using the organ-on-chip technology.
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PMC11064533
The cell line of a urinary bladder carcinoma—5637, was cultivated in RPMI medium with the addition of 10% fetal bovine serum, 2 mM L-glutamine, 1 mM sodium pyruvate, and 1% penicillin/streptomycin.
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PMC10669128
They demonstrated selinexor’s potential as a therapeutic agent for DDLPS, given its superiority in terms of the umor response in all PDXs when compared to doxorubicin, regardless of the MDM2 amplification and histological differentiations .
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PMC10605143
MCF10A and MCF12A cells were transduced with lentiviruses and selected using a medium supplemented with 1 μg/mL puromycin (Life Technologies/Thermo Fisher Scientific, Waltham, MA, USA), as described in Ref .
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PMC9960565
Nonetheless, it is important to emphasize that the interactions observed in vitro may not be precisely what happens in vivo.
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PMC11725127
Figure 2 USP2 is a novel target of GA. (
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PMC11767725
Progressive insulin resistance and declining insulin secretion are hallmarks.
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PMC11224020
Counting beads were used to normalize the number of cells to the number of beads.
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PMC3019555
After 2ME2 or TX treatment, the HIF-1α MBs were redistributed into larger cytoplasmic clusters and exhibited more constrained, nondirectional movements rather than the long-range trafficking observed in untreated cells (Fig. 3 C and Videos 3 and 4).
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PMC11705862
Data are represented as a fold change of secreted noradrenaline in cells stimulated with 100 mM potassium (evoked noradrenaline release) compared to cells stimulated with 5 mM potassium (baseline noradrenaline secretion, represented as a dotted line).
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PMC11519583
The finding that both Wnt5b and Wnt11 were highly expressed in glycerol-injected muscles compared with those in Ctx-injected muscles raised the questions of how they regulate the versatility of Ror2-mediated signaling and whether they bind to Ror2 additively, competitively, or synergistically.
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PMC9429973
Demographic and hematological characteristics of patients are described in Figure 1A.
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PMC10840195
In the drug resistance, inhibiting Wnt signaling can make cancer cells sensitive to chemotherapy.
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PMC4270159
c. Wash cells with 1× cold PBS and spin at 1200 rpm for 5 min.
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PMC9429973
Uncomplicated VOCs had the highest annual costs for ED, ICU and hospitalizations.
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PMC9844987
Gene RGS14 has three decomposed promoters localized within its promoter (Figure 5D), for which SNP rs56235845 (chr5:177371039 T/G) was strongly associated with the contribution to the overall promoter activity for only decomposed promoters 1 and 2 (frQTL beta = 0.210, –0.181, –0.062; FDR = 2.42 × 10, 2.54×10, 2.64×10, for decomposed promoters 1, 2, and 3, respectively).
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PMC11420784
Significance is indicated by the P value.
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PMC10813895
Understanding the modulation of ELF5 expression within luminal epithelia and cKIT+ luminal progenitors is important for developing therapies targeted at age-related breast cancer prevention.
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PMC11665584
CUT&Tag-Seq for PITX1 allowed us to reliably discern binding adjacent to genes that had increased expression following expression of PITX1 in the skin.
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PMC9429973
In the ND Ph+ ALL cohort, 1 of 34 pts who received at least 1 full cycle died in CR; the other 33 are in ongoing hematologic remission.
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PMC11224020
Together, these data suggest that steady-state migration of DCs to lymph nodes might result, at least in part, from the events of shape changes that they experience while patrolling the complex environment of the skin, suggesting a contribution of cell mechanics to this process.
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PMC11682224
This indicates that CHD1L can promote the progression of SCC (Fig. 1).Fig.
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PMC11541241
Potential homologues of SFP1 are identified in most species investigated, with the exceptions of B. graminis f. sp. tritici, F. graminearum, P. infestans, and U. maydis.
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PMC5363531
Differently from the results observed testing IC50 doses, the simultaneous administration of PEM and dasatinib did not affect cell apoptosis, whereas the sequential mD induced a 24% of cell apoptosis (Figure 4A).
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PMC11765988
Other drugs: Azathioprine (AZA), Leflunomide, and Rituximab, an anti-CD20 B-lymphocyte antibody used as a third-line drug .
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PMC9080589
In brief, PTC cells (1 × 10 cells per well) were seeded into 96-well culture plates and cultured for 1–4 days after transfection.
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PMC11721587
Colonies with HA-Fu constructs expressed at levels similar to that of the endogenous Fu were picked and stored for further experiments.
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PMC11271278
We downloaded the TCGA ATAC-seq data from the UCSC Xena Browser (URL: https://xenabrowser.net/datapages/?dataset=TCGA_ATAC_peak_Log2Counts_dedup_sample&host=https%3A%2F%2Fatacseq.xenahubs.net&removeHub=https%3A%2F%2Fxena.treehouse.gi.ucsc.edu%3A443; version: 2018-06-21), which contains log2-transformed normalized ATAC-seq insertion counts for each tested sample across the identified pan-cancer ATAC peaks.
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PMC9429973
Latest recorded LoT was selected as the index therapy for every patient.
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PMC8357004
Total RNA (100 ng) was reverse-transcribed to complementary DNA (cDNA) by using the RevertAid™ First Strand cDNA Synthesis Kit (Fermentas, K1622 for 100 reactions), according to the protocol.
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PMC11471157
Amino acid analysis was outsourced to the Industrial Technology Center of Saga (Saga, Japan).
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PMC9221284
However, c-MycS, c-MycS1, and c-MycS2 lack (Figure S1) the first 100, 109, and 133 amino acids, respectively, which contain two phosphorylation sites.
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PMC11401358
Data represent the mean ± SD. (
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PMC9429973
The TM frailty score is more appropriate than the IMWG GA for evaluating frailty in the Chinese population.
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PMC11723947
Source data are provided in the Source data file.
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PMC10994876
The experiments were conducted in duplicate or triplicate biological replicates.
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PMC11750696
Murine T cells with a genetic alteration in KDELR display heightened eIF2 phosphorylation and CHOP expression, which correlates with a decrease in naïve T cell counts in vivo (28).
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PMC11705862
Our data demonstrated that prolonged exposure to pro-inflammatory cytokines, TNF-α and IFN-ɣ, significantly decreases the expression of IRIS-1 and 2 in SH-SY5Y cells.
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PMC11488203
Moreover, taxol-loaded exosomes derived from all three MSC primary cultures (MSC 241111, MSC280416, and MSC180314) were incubated with 5 µg of an IgG1 control antibody, respectively and tested in A549 cells in a similar experimental setup.
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PMC8557138
The endothelial cells produced a significantly high number of sprouts and also vascularized the spheroids with blood vessels of irregular morphology (Ehsan et al. 2014).
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PMC6803987
In the meantime, liver sections of the high dose group showed no inflammatory cell infiltration and cell degeneration (Figure 9E).
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PMC11476222
Previous studies have suggested that STs are abundantly expressed in certain cancers and tumors, while SPHP plays a significant role in inflammation and cancer progression .
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PMC11682525
Hypoxic preconditioning enhances the survival and oxidative stress resilience of hHFSCs and SH-SY5Y cells, offering potential benefits for central nervous system cell therapy.
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