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PMC9429973
The low median score overall indicates an urgent need for continuous education.
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PMC9429973
Secondary endpoints included overall survival, progression-free survival (PFS), and production feasibility.
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PMC11774251
HaCaT cells at over 60% confluence in 12-well plates were treated with Tan-I for 6–8 hours, followed by TNF-α (100 ng/mL, Sino Biological, Beijing, China) co-stimulation for 24 hours.
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PMC8316344
However, knocking TRIB2 out in Bel-7404 cells remarkably boosted the basal and increased labile iron level induced by RSL3 and erastin, and these effects could be reversed by simultaneously overexpressing TRIB2 (Fig. 3E), suggesting that TRIB2 acts to mitigate labile iron.
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PMC9429973
Parsaclisib may be an effective oral treatment for AIHA, and a randomized, controlled phase 3 trial in wAIHA is now recruiting (NCT05073458).
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PMC9429973
The analysis of long-term results of haplo-HSCT was performed according to the Kaplan-Meier method.
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PMC9429973
Methods: Included 105 pts: DLBCL NOS, age 18-65, stage IV, IPI≥2, CR/PR after x6 CHOP/EPOCH+R from 2010 to 2019 at NMRC of Oncology named after N.N.Petrov of MoH of Russia were retrospectively analyzed.
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PMC10999934
The analysis of these DEGs using KEGG indicated that they were mainly enriched in ribosome, protein processing in endoplasmic reticulum, and chemical carcinogenesis – reactive oxygen species (Fig. 2D).Fig.
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PMC8389560
Each experiment was repeated three times with separate cell cultures.
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PMC11388384
Numerical simulations of SHH diffusion were performed in MATLAB, and results were visualized using ggplot2 in R (58).
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PMC10870498
The bottom of the chamber was supplied with RPMI-1640 medium containing 10% FBS.
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PMC11757131
Detection of proteins related to the mTOR signaling pathway using Western blotting. (
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PMC9812014
PV is a picornavirus in the enterovirus C family.
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PMC11753435
The CLIP architecture was adapted from Radford et al. (25).
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PMC11388384
plotted as black lines.
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PMC7039683
Statistical analyses were performed as previously described (Leslie et al., 2017), using an inverse variance-weighted fixed-effects meta-analysis.
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PMC9268620
Latifah et al. showed that the programmed cell death induced by these anthraquinones was activated by Mg/Ca-dependent endonuclease, which led to DNA fragmentation.
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PMC2614416
And, cancer cells avoid apoptosis caused by excessive oxygen free radicals by activating protein kinase B (PKB; also known as c-Akt) which protects them from apoptosis .
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PMC11532793
This article adds three new refinements to the pipeline that dramatically decrease the computational overhead and storage requirements so that DTE analysis of very large datasets becomes practical.
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PMC8358006
To further explore genomic architecture of GSDs activated genes, we searched for TF-binding motifs enriched in the H3K4me3 and H3K27ac peaks of 208 upregulated genes using a motif analysis algorithm.
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PMC11743414
Moreover, with the development of gene chip and high-throughput sequencing technology, more studies have shown that gene signature has great potential as a biomarker in predicting cancer prognosis .
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PMC11790971
The classification results revealed phenotypic differences among CHO cell lines across the three passages, with the poorest performance observed in passage 0 (Fig. 2).
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PMC9351137
Overall, our results support the existence of evolutionarily conserved diverse roles of chromatin remodeling complexes, whereby subunits of the SRCAP and p400/Tip60 complexes relocate from the interphase chromatin to the mitotic apparatus, playing moonlighting functions required for proper execution of cell division.
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PMC11673128
Similarly, when examining CALR and CD47 expression over time, we opted for reduced TKIs concentrations (i.e., crizotinib 120 nM and lorlatinib 100 nM), as higher levels provided intolerable toxicity for long-term exposure analysis.
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PMC10006224
In situ Hi-C data come from three replicates in mock transfected (control) MCF10A cells and four replicates in NIPBL KD cells (see Supplementary Fig. 6).
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PMC11585254
CXCL13-stimulated ERK1/2 phosphorylation was examined in β-arrestin1/2 DKO cells expressing FLAG-tagged CXCR5 with (+βarr1/2) or without (pcDNA) β-arrestin1 and β-arrestin2 re-expression.
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PMC11617590
Therefore, in this study, we examined the effect of SFN on the growth and apoptosis of Mia PaCa‐2 cells through GSK‐3β.
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PMC5535901
Both I3C and DIM have been reported to possess pro-apoptotic, anti-proliferative and anti-carcinogenic properties via modulation of immune pathways.
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PMC11591794
First, the experiments were conducted exclusively on HeLa cell lines, which may not fully represent the complexity of cervical cancer in vivo.
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PMC11429241
Tumor models have allowed scientists to make significant progress in cancer research.
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PMC9952933
The cells were treated with CAP or carrier gas argon for 10 s and were transferred to 96-well plates.
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PMC11674441
The list of selected neoantigens for each case is provided in Table 3.
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PMC11228511
In most somatic cells, the main components of the nuclear lamina are the A-type lamins (lamin A and lamin C; products of LMNA) and the B-type lamins (lamin B1 and lamin B2; products of LMNB1 and LMNB2, respectively) (9).
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PMC11271800
A low ratio of cytotoxic T cells/Treg cells suggests the presence of an immunosuppressive microenvironment within the tumor, whereas the ratio of the two in GIST is lower than that of cervical cancer, suggesting that there is a more potent microenvironment of immunosuppression.
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PMC11467964
Consensus matrix heatmap defining two clusters (k = 2) and their correlation area. (
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PMC11740907
This, in turn, contributes to the advancement of nanomedicine therapies that are more effective.
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PMC11786767
Ki-67 also excludes the cytoplasm from condensed chromosomes during mitosis (23).
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PMC6379402
Thus, we only present the GCD-11 distances between real and model networks (with lower GCD-11 distances relating to better fits).
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PMC11701801
Samples of tumor xenografts were lysed using Precellys Evolution (M&S Instruments) with 500 μL of RIPA buffer (CST, 9806) supplemented with Halt proteinase and phosphatase inhibitor cocktail (Thermo Fisher Scientific, 78440).
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PMC11190062
Moreover, expression of several TLRs increases from diagnosis to relapse in individual patients (23).
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PMC10719213
Next, the variants were filtered for minimum of 15 variant supporting reads using snpSift filter with the expression DP*AF ≥15 and for minimum of three variant supporting reads on each strand (expression DP4 ≥3 & DP4 ≥3).
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PMC11700165
Anti-SYK was used to detect SYK fusion proteins.
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PMC11406030
Western blot membranes were hybridized with LMTK3 biotin-labeled peptide #1 and LMTK3 antibody, followed by detection with the avidin-biotin complex.
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PMC8140214
Mean±SD valuesare the representative of four independent experiments.
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PMC9429973
Summary/Conclusion: ZNF208, a member of zing-finger binding transcription factor family, has been reported to be play role as tumor suppressor gene in various cancers through distant signaling pathways (3,6,7).
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PMC7917457
VALO-D102 codes for two human immunostimulatory proteins: OX40L and CD40L.
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PMC7022782
By comparing the cytotoxicity results of the ICG-loaded NPs and unloaded PECA-NPs previously studied , it is possible to argue that cytotoxicity is mainly due to the carrier and it is dose-dependent.
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PMC10907726
However, it is not yet known whether DATS can inhibit OS progression by regulating the EGFR pathway and its downstream signaling.
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PMC11655498
The host miR-18a suppresses the ATM-mediated DNA damage response in an EBV-dependent manner, leading to EBV reactivation and host genomic instability (Cao et al., 2018).
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PMC11394112
From week 2 up to week 6, 1~4 U2932-Luc- or VAL-Luc- or PBS-injected NSG-IL6 mice were euthanized each week.
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PMC7369657
Cells were gently vortexed and incubated for 15 min at 25°C in the dark.
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PMC9920575
A preliminary analysis of the phytochemical content in the S. chinantlense extract revealed that the main components are terpenes, flavonoids (flavones and flavonols), saponins and tannins and that other phytochemicals reported in the species S. edule, such as peroxidases, sterols, phenols, polyphenols, fatty acid esters, carotenoids, vitamin c, antioxidants, and cucurbitacins, are also present .
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PMC11366496
The si‐RNF122#2 has the highest knockdown efficiency and will be used as a follow‐up study.
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PMC3675084
Survivin depletion in paclitaxel-resistant ovarian cancer cells could play a role in the BPR0L075-induced mitotic catastrophe.
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PMC9429973
Median (95% CI) longest durations of RBC-TI were 72.0 (62.0–103.0) d for luspatercept and 71.5 (62.0–NA) for placebo, though the placebo result was driven by 2 pts.
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PMC11218145
Fig. 1Effects of TB on ERK1/2 and p38 phosphorylation and BAX.
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PMC10495912
This study was designed to investigate the TQ effects on hydrogen peroxide-induced cytotoxicity.
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PMC9100622
The obtained reads were aligned in the human reference genome (GRCh37/hg19) using bowtie2-2.2.9 .
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PMC6803987
The results indicated that esculetin can significantly inhibit the secretion of HBsAg and HBeAg at a non-toxic concentration range, and the inhibitory effect of esculetin on antigen was dose- and time-dependent.
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PMC8956657
B Crystal structure of NF-ĸB p50 ORF4b NLS bound to IMPα3 at 2.15 Å resolution (see Supplementary Table 11 for data collection and refinement statistics).
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PMC7504302
This has been obtrusive by way of augmented expression of HIF-1α (hypoxia-inducible factor 1α) and elevated blood neovascularization as measured via vessel density .
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PMC11751675
However, it showed no inhibitory effects against the tested strains of influenza viruses (influenza A H1N1, influenza A H3N2, and influenza B).
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PMC10747160
In the future, we hope to perform more experiments to elucidate the binding dynamics and epitope locations involved in Griffithsin binding to spike protein.
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PMC11775197
PPAR is an endogenous or exogenous ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily.
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PMC11365983
Evidence that these alterations are not confined to Gli1, was provided by the significantly increased expression of Gli2 (the main activator of mammalian Hh signaling) and Ptch1 observed in Foxc1-overexpressing fibroblasts (Fig. 3F).
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PMC11477621
As one of the most serious threats to human health, cancer has become the leading cause of death worldwide after cardiovascular and cerebrovascular diseases .
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PMC10329074
Data were expressed as the mean ± s.d.,
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PMC11285179
We further investigated the effects of retinoic acid by daily gavage on tumor growth and vascular normalization in vivo.
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PMC11188874
Patient CD138 cells were then treated with each HDAC6 inhibitor and cocultured with autologous patient CD8 T-cells (E:T 2.5:1).
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PMC9429973
Higher risk was defined as del(17p) and/or TP53 mutation [del(17p)/TP53m], unmutated IGHV (uIGHV), or complex karyotype (CK, ≥3 chromosomal abnormalities).
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PMC10976516
The last two decades have shown a steady advance in the targeted use of other and above-mentioned engineered OVs against a broad range of solid tumors in an extensive number of (pre)clinical trials that confirmed OVs’ potential as immunotherapeutic tools too.
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PMC9429973
Treatment was well tolerated in the overall population and all subgroups.
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PMC9429973
HHC was found to be significantly correlated with the occurrence of deep vein thrombosis with an odds ratio of 3.54 with a 95% confidence interval [1.76 - 16.4] compared to the control group.
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PMC11569208
B–D) 786-0 cells were infected with either VSV∆51-non targeting control (NTC) or VSV∆51-shACP2 (with indicated multiplicity of infection, MOI). (
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PMC11143482
Body weight on day 0 was measured prior to the tumour inoculation.
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PMC10024132
PE-anti-Vδ2 (#555739) and FITC-anti-Vγ9 (#TCR1720, Invitrogen) were used to identify γ9δ2 T cells.
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PMC9841531
For intracellular pH determination, the fluorescence ratio between the emission wavelengths 430 nM and 490 nm was determined and plotted against the calibration curve.
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PMC11676169
The ability of BCAT1 to complex with KU70 and KU80 suggests that the former directly regulates the c-NHEJ repair pathway.
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PMC11615218
CAR-T cell products manufactured by ex vivo expansion are predominantly composed of antigen-experienced T cells, with the two major subsets being TEM and TCM .
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PMC11772585
Data are shown as mean ± SEM. ***
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PMC9429973
Image: Summary/Conclusion: A comparison of PROs in real-life NTE NDMM pts treated with VMP vs Rd showed a worse HRQoL in the VMP arm early in the treatment course that improved thereafter.
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PMC9398137
BCL2 is an important modulator of sensitivity to S63845 in DLBCL and Burkitt lymphoma.
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PMC9895440
PT.58.14945655), LDHA (Hs.
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PMC6160470
Syntheses of new compounds: MAC-1, MAC-1Amide, MAC-4, and MAC-4Amide, as well as DAC-4 and DAC-4Amide are described in the Supplementary information of this paper (Supplementary Figs S1 and S2).
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PMC11583010
The 15A7.5-Am and 5A12.2-Am ADCs both killed SUM190 and MDA-MB-468 tumor cell lines with similar EC50 values.
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PMC9429973
Aims: We aim to characterize the secretome profile of MSCs derived from BM of AML patients at diagnosis (AML-MSCs) with respect to MSCs derived from healthy donors (h-MSCs), and h-MSCs when co-cultured with AML blasts (induced, iAML-MSCs) in a predictive three-dimensional (3D) AML-niche model, including the mechanism whereby normal hematopoiesis is impaired and leukemia advantaged.
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PMC11566417
b GO-term enrichment Manhattan plots of GO terms associated with biological processes (BP) enriched in each of the conditions over the log2 of the p-value for each enrichment.
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PMC11657695
Boxes represent the interquartile range, upper and lower whiskers the largest and smallest values respectively.
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PMC11742670
Address: 723 − 13 Tomari, Itoshima, 819–1111 Japan.
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PMC11718809
In the ceRNA network examined in this study, MUC1 is associated with mastitis resistance and milk fat synthesis .
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PMC11489351
Each biological replicate is the average of three technical replicates (three different wells for each condition).
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PMC11739504
Brog Decloaker RTU (Biocare Medical) was used for heat induced antigen retrieval and the paraffin-embedded sections were blocked for 1 h followed by primary antibody incubation at 4℃ overnight.
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PMC11457557
Several genes in this region are potential candidates, with GRB2 being notably increased during retinal stress and neovascularization.
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PMC11574271
F The invasion ability was evaluated by trans-well assay.
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PMC10926885
The 50 proteins that interact with NDE1 are shown in Figure 1, along with the connections between them based on how much they interact with one another (Figure 4A).
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PMC11803149
On day 12 after the adoptive transfer of OT-I T cells with Epas1-Crispr or control-Crispr into young recipient mice with B16-OVA tumors, we collected tumor-infiltrating lymphocytes and sorted OT-I T cells.
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PMC11128598
In fact, CQ encapsulation within nanoparticles has been shown to enhance its antitumor efficacy, prolonging drug circulation and reducing systemic toxicity in vivo (19).
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PMC9429973
We propose that DNA methylation-based risk assessment may serve as a promising complement for current standards in prognostic classification of AML.
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PMC11727306
Abrin, a proteinaceous toxin found in the seeds of the plant Abrus precatorius (rosary pea), is mainly known as a potent inhibitor of protein synthesis but, in low doses, has also been implicated as triggering autoimmune demyelinating disease, a condition that causes damage to the myelin sheath covering of nerve fibers .
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PMC10761571
The crystalline structure of NPs was evaluated by XRD analysis at k = 1.79 Å (Philips, PW1730, Netherland).
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