OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9429973	J. Villarrubia, M. Wasserstein, A. Barbato, R. C. Gallagher, R. Giugliani, N. B. Guelbert, J. B. Hennermann, C. Hollak, T. Ikezoe, R. Lachmann, O. Lidove, P. Mabe, E. Mengel, M. Scarpa, E. Senates, M. Tchan, B. L. Thurberg, A. Yarramaneni, A. M. Rawlings, Y. Kim, M. Kumar Hematology, Hospital Universitario Ramón y Cajal, Madrid, Spain; Children’s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, United States of America; Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy; Pediatrics, University of California, San Francisco, CA, United States of America; Med Genet Serv & DR BRASIL Research Grp, HCPA, Dept Genetics, UFRGS & INAGEMP, Porto Alegre, Brazil; Reina Fabiola University Clinic, Córdoba, Argentina; Pediatric and Adolescent Medicine, Villa Metabolica, University Medical Center, Mainz, Germany; Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands; Hematology, Fukushima Medical University, Fukushima, Japan; Charles Dent Metabolic Unit, National Hospital for Neurology and Neurosurgery, London, United Kingdom; La Croix St Simon Hospital, Paris, France; Clinica Santa Maria, Santiago, Chile; Clinical Science for LSD, SpinCS, Hochheim, Germany; Regional Coordinator Centre for Rare Diseases, University Hospital of Udine, Udine, Italy; Istanbul Medeniyet University, Istanbul, Turkey; Genetic Medicine, Westmead Hospital, Sydney, Australia; Sanofi, Cambridge, MA; Sanofi, Bridgewater, NJ, United States of America; Sanofi, Paris, France Background: Acid sphingomyelinase deficiency (ASMD) is a rare debilitating lysosomal storage disease characterized by pulmonary dysfunction, hepatosplenomegaly, thrombocytopenia/bleeding issues, and dyslipidemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11216402	As GC cell lines have no matched germline samples, CNVs were call against a nonmatched normal sample.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "GC", "cell", "lines", "have", ...
PMC11476264	Compared with FBXO11 knockdown alone, FBXO11 and ZEB1 double knockdown increased E-cadherin and decreased N-cadherin protein expression, which is similar to the result of ZEB1 knockdown alone (Figure 5A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11766174	CA-ICC was validated with HIV-infected cell lines and primary cells, and its application was tested with blood samples collected from animal models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CA-ICC"...
PMC9509578	Hypoxia triggers cancer MDR by reducing the efficacy of chemotherapeutic drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hypoxia", "triggers", "cancer", "MDR", "by", "reducing", "the", "efficacy", "of", "ch...
PMC11643361	All compounds exhibited anticancer activity in the micromolar range, and Ru(II) scorpionates 46 and 47 exhibited antiproliferative activity comparable to that of cisplatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11335267	p < 0.01; Studentʼs t-test (n = 8 mice per genotype). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.01", ";", "Studentʼs", "t-test", "(", "n"...
PMC11461833	HERVK induces cellular senescence and inflammation by activating the cGAS-STING pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HERVK", "induces", "cellular", "senescence", "and", "inflammation", "by", "activating", "th...
PMC11633763	For instance, Circ‐CTNNB1 promotes m6A modification by interacting with RBM15 in osteosarcoma cells to drive glucose metabolism reprogramming .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "instance", ",", "Circ‐CTNN...
PMC6617630	MYC, BCL2, and BCL6 rearrangements were analyzed using break-apart FISH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MYC", ",", "BCL2", ",", "and", "BCL6", "rearrangements", "were", "analyzed", ...
PMC11247842	We also included CpG islands from the UCSC genome browser.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "included", "CpG", "islands", "from", "the", "UCSC", "genome", "browser", "."...
PMC11590005	Additionally, the desire to be socially acceptable may also have interfered with the responses .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "the", "desire", "to", "be", "socially"...
PMC10222971	In view of the results obtained, it can be drawn that the most cytotoxic naphthoquinone derivative in all the cell lines tested is the derivative 5-O-acyl juglone (6), with a percentage of viable cells of 18.3%, 0.5%, and 7.2% on IGROV-1, SK-MEL-28, and HEK-293 cells, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11457557	Previous family clustering studies in the Diabetes Control and Complications Trial (DCCT) cohort have shown that those individuals with a strong family history of severe DR had an OR of 3.1 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11024707	Venous blood samples from patients, siblings and children in the control group were collected in ethylenediamine tetraacetic acid (EDTA) tubes, independent of variables such as time, hunger, and satiety.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11799620	However, prevention can help to manage this toxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "prevention", "can", "help", "to", "manage", "this", "toxicity", "." ] } ]
PMC11451940	However, the obtained data showed an intriguing tapestry of redox processes occurring during the oxidation and reduction of the copper(ii) complexes 2 and 3, zinc(ii) complex 5, and free lapachol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11248911	Non-bonded interactions were treated with a 12 Å cutoff distance and the neighbor searching list was buffered with the Verlet cutoff-scheme and the long-range electrostatic interactions were treated with the particle mesh Ewald (PME) method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Buccal epithelium swab was taken an OLDANS plastic-viscose probe-tampon (Russia).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Buccal", "epithelium", "swab", "was", "taken", "an", "OLDANS", "plastic-viscose", ...
PMC11714165	Subsequently, cells were digested using 0.25% trypsin, resuspended in PBS, and subjected to quantitative analysis of delivery efficiency using flow cytometry (CytoFLEX, BECKMAN, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10777969	Human prostate normal PTEN2 cells were cultured in RPMI 1640 (Sigma) medium supplemented with penicillin–streptomycin mix (Sigma), 2 mM glutamine (Sigma), and fetal bovine serum (BII).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9532503	The LpHT output was subjected to further purification by anion exchange (AEX) chromatography using Q-sepharose FF (GE healthcare, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11481779	For detailed per-chromosome results, see Supplementary Fig. 4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "detailed", "per-chromosome", "results", ",", "see", "Supplementary", "Fig.", "4", "." ] } ]
PMC11766309	Afterward, we combined the findings of the survival study with those of the DFI and DSS analyses, and the findings, which were fundamentally identical to the results from the OS and DFI analyses, revealed that a high expression of YKT6 was strongly linked to a poorer prognosis in cancer patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Odzharova, A. Semenova, G. Tumyan, E. Osmanov, T. Byalik Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); pathomorphology; oncohematology; radiology, «N.N. Blokhin Medical Research Center of Oncology», Moscow, Russia Background: Richter syndrome is a transformation of chronic lymphocytic leukemia into DLBCL, occurring in about 2-15% of patients (pts) with CLL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878562	Moreover, VAL-wt support in vitro chemotaxis of VAL cells in which ACKR3 was genetically deleted (VAL-ko).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "VAL-wt", "suppor...
PMC9429973	Eighty-nine per cent of patients had B-cell non-Hodkin lymphoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eighty-nine", "per", "cent", "of", "patients", "had", "B-cell", "non-Hodkin", "lymphoma", "." ] } ]
PMC5600151	Many kinds of dendrimers have been explored for nucleic acid or drug delivery, including poly(amidoamine) dendrimers , poly(propylene imine) dendrimers , poly(l-lysine) dendrimers , carbosilane dendrimers , and triazine dendrimers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706776	p < 0.05; **: p < 0.01 (Mann–Whitney tests). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", ";", "", "", ":", ...
PMC8978939	Assessed by RT-qPCR, mRNA levels showed that VHL-P138R-Venus and VHL-L163R-Venus variants were similar and even higher than VHL-WT-Venus mRNA levels ( Figure 1B ), suggesting that transcription levels are not responsible for the differences in protein levels evidenced by Western blot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9910796	As a control, immature particles with a well-defined core shell as well as full nucleoid-containing virions were detected under permissive conditions (S4A–S4D Fig).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10114490	E Intracellular levels of reduced glutathione (GSH) and S-adenosyl-L-methionine (SAM) in diHLC-T and HepG2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "E", "Intracellular", ...
PMC11269933	After 2-3 days, growth transformants were inoculated into (-Leu, -Trp) medium and allowed to grow overnight at 30°C with continuous shaking at 200 rpm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11781181	IHC staining was performed overnight at 4 °C as described previously using rabbit polyclonal anti-FSP1 (diluted 1:400, PA5-28727, Thermo), mouse monoclonal anti-4-hydroxynonenal (4-HNE) (diluted 1:100, ab48506, Abcam), rabbit monoclonal anti-transferrin receptor (TFRC; diluted 1:400, ab214039, Abcam), rabbit monoclonal anti-six-transmembrane epithelial antigen of the prostate 3 (STEAP3) (diluted 1:100, D164478, sangon biotech), rabbit monoclonal anti-ACSL4 (diluted 1:200, ab155282, Abcam), rabbit monoclonal anti-ALOX15 (diluted 1:800, ab244205, Abcam), rabbit monoclonal anti-FTH1 (diluted 1:400, ab183781, Abcam), mouse monoclonal anti-8-hydroxy-2′-deoxyguanosine (8-OHdG) (diluted 1:200, ab48508, Abcam), rabbit polyclonal anti-NCOA4 (diluted 1:200, ab111885, Abcam), mouse monoclonal anti-LPCAT3 (diluted 1:200, ab239585, Abcam), mouse monoclonal anti-divalent metal transporter 1 (DMT1) (diluted 1:200, ab55735, Abcam), and rabbit monoclonal anti-IgG isotype control (ab172730, Abcam) antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746942	Analysis revealed that S1PR3 was mainly localized to the epidermal layer, whereas S1PR2 and S1PR1 were primarily expressed in dermal fibroblasts and endothelial cells, respectively (Fig. 2C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7229095	However, further checks are needed to determine whether these conditions are also capable of growing non-producers, which may not be the case since the Picked/Growth ratio was similar (~ 30%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11643491	The solutions with the droplets were stirred for 3 h to ensure complete solvent evaporation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "solutions", "with", "the", "droplets", "were", "stir...
PMC11298021	To further confirm the transfection efficiency, flow cytometry was performed to determine the exact number of FAM-labeled (transfected) cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "furthe...
PMC9429973	Aims: Here we present neoantigen evaluations from reprocessing de novo Multiple Myeloma patients recruited into the CoMMpass study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "Here", "we", "...
PMC10604092	Notably, the locomotor activities of the force-fed SLC-transplanted rats decreased over time (Figure 6H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "the", "locomotor", "activities", ...
PMC11300639	Data are presented as the mean ± SEM of three replicates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "the", "mean", "±", "SEM", "of", "three", "rep...
PMC11739670	Differences in the MHCIα3 domain are unlikely to be the main contributors to changes in the binding affinities for two reasons.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Differences", "in", ...
PMC11680049	However, when the callus tissue was cultivated for 12 cycles, a gradual browning was observed, yet the callus retained a high growth rate, with light areas forming in the central part (Figure 5d,e).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11655536	As shown in Fig. 1F, HA significantly decreased the viability of the MM cell lines, and the inhibition effect is dose-dependent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", ...
PMC9436459	MDAAs with a prenyl group or a modified prenyl group at C-7″ of the methylcyclohexene ring were rare, and only six examples have been reported.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11795610	All data are expressed as mean ± SD (n = 3). **	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "data", "are", "expressed", "as", "mean", "±", ...
PMC11489175	A role for DUBs in supporting the growth of tumor cells resistant to platinum agents emerges from the literature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "role", "for", "DUBs", ...
PMC6835428	Indeed, particles with diameters greater than 10 nm are scarcely drained by the blood vessels (see Section 2.2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed", ",", "pa...
PMC11714165	Intercepting the detrimental interplay between osteoclasts and osteosarcoma cells is considered as an option for osteosarcoma treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Intercepting", "the", "detrimental", "interplay", ...
PMC11588008	Therefore, we use the PM active metabolite of CTX for experimental research in later experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", "use", "the", "PM", "acti...
PMC11610461	Kidney renal clear cell carcinoma (KIRC) is one of the most prevalent subtypes of KC, accounting for more than 80% of cases of renal malignancy (Hsieh et al., 2017; Brozovich et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629192	These therapies are initiated early in the disease course, often at diagnosis, with the primary objective of reducing relapse frequency and slowing the progression of disability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11453295	In addition, we hope to identify mediators that drive estrogen-induced tumorigenesis using the mouse mammary intraductal (MIND) model, which better recapitulates the progression of ILC and response to estrogen in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10565698	This study screened a novel circRNA, hsa_circRNA_101889 (circUSP10), upregulated in LC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "screened", "a", "novel", "circRNA", ",", ...
PMC11337594	The error bars represent the means ± SDs (n = 3). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "error", "bars", "represent", "the", "means", "±", "SDs", ...
PMC9429973	Aims: Thromboembolic prophylaxis is critical in managing COVID-19 patients on ECMO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "Thromboembolic", "prophylaxis", "is", "critical", "in", "managing", ...
PMC11748618	Training data was limited to individuals of African Ancestry to reduce effects of population stratification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Training", "data", "was", "limited", "to", "individuals", "...
PMC10587429	Class II biological safety cabinet. -	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Class", "II", "biological", "safety", "cabinet", ".", "-" ] } ]
PMC11594588	The development of molecular techniques has allowed for the identification of new molecules as potential biomarkers of diagnostic, prognostic, and therapeutic importance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10854447	Found: C, 63.38; H, 3.91; N, 22.03.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Found", ":", "C", ",", "63.38", ";", "H", ",", "3.91", ";", ...
PMC11286266	The identity of the CHO-K1 cell lines has been authenticated by successfully targeting essential genes using a species-specific CRISPR whole-genome library and sequencing the WT or mutant alleles of the genes studied, which confirmed the sequences reported for the corresponding genome.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615828	Precise perturbation of endocytosis to inhibit virus entry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Precise", "perturbation", "of", "endocytosis", "to", "inhibit", "virus", "entry", "." ] } ]
PMC11394227	Annexin V-PE/7-AAD apoptosis detection kit (Vazyme, Nanjing, China) was used for the determination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Annexin", "V-PE/7-AAD", "apoptosis", "detection", ...
PMC9429973	Results: Thirty-five hospitals/clinics are currently participating to REALYSA across France.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Thirty-five", "hospitals/clinics", "are", "currently", "participating", "to", ...
PMC8540611	HL-60 and CEM-SS cells were more resistant to the effects of AuNP.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HL-60", "and", "CEM-SS", "cells", "were", "more", "resistant", "to",...
PMC11786767	∗∗P < 0.01; ∗∗∗P < 0.001; one-way ANOVA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "∗∗P", "<", "0.01", ";", "∗∗∗P", "<", "0.001", ";", "one-way", "ANOVA", "." ] } ]
PMC8873393	Then RNA-seq from the pool of three biological replicates was performed of the resulting cytoplasmic fraction and chromatin pellet extract, yielding at least 180 million uniquely mapped reads from each sample (Table S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11609529	ImageJ was utilized to analyze and quantify staining-positive cells in sections of individual tumors (n = 6 in each group, mean ± SD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11772585	β-Tubulin was used for the normalization control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β-Tubulin", "was", "used", "for", "the", "normalization", "control", "." ] } ]
PMC11770130	For human NTSR2, NTS behaved as a neutral antagonist in COS cells and HEK293 cells but an activator of MEK-ERK signaling in CHO cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O"...
PMC11422150	The hAMSC treatment suppressed the local accumulation of macrophages at SCI (Figure 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "hAMSC", "treatment", "suppressed", "the", "local", "...
PMC9429973	NKG2D is an activating receptor on NK cells that recognizes ligands on the surface of tumor cells and plays a crucial role in tumor cell killing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC6024716	The polyamine content and protein concentration was determined for each sample.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "polyamine", "content", "and", "protein", "concentration", "was", "determined", "for"...
PMC9512971	Two patients in the camostat mesilate group discontinued treatment due to adverse drug reactions (hepatic function abnormal and drug eruption).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "patie...
PMC10854447	The newly designed 1,2,4-oxadiazoles 7a–o were considered to be sterically fixed counterparts of the previously discovered linear carboximidamide derivatives 6a–o (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Preclinical studies suggest that CBL-mutant cells are dependent on FLT3 signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Preclinical", "studies", "suggest", "that", "CBL-mutant", "cells", "are", "dependent", "on"...
PMC6799808	a–c A549 and A427 cells were treated with GLPT for 24 h, rapamycin (Rapa) for 2 h or AZD8055 for 2 h at the indicated concentrations, and western blotting was then performed with the indicated antibodies.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11583690	The SI value was calculated using the following formula (5):(5)SI = (IC50 of normal cells)/(IC50 of cancer cells) Here, “normal cells” refer specifically to the Hs68 cell line, while “cancer cells” include the VcAP, A549, and MCF-7 cell lines .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6650823	These findings raise the hope that the prevention of CF-related pathologies may be possible before or soon after birth with timely administration of targeted therapies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9813422	Moreu et al. observed that HBV tethering at CGIs was not affected in HBV-ΔX, suggesting that HBx does not drive the tethering of HBV cccDNA in the host chromosomes (56).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11429241	For the A2780 cell line, although all the cells migrated to the scaffold, better attachment was observed with a pore size of 40 µm.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11298021	Research on clinical models and trials has demonstrated the anti-cancer properties of rapamycin, one of the mTOR inhibitors currently available.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Research", "on", ...
PMC11675244	Segments of Frizzled (Fzd) receptors have also been shown to enhance Wnt inhibition, as Fzd7 fractions were found to reduce β-catenin-dependent gene transcription in HCC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: 15 pts were enrolled (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "15", "pts", "were", "enrolled", "(", "Table", "1", ")", "." ] } ]
PMC9429973	On the other hand, there is scarce data regarding the safety and efficacy of HDC in patients with hematological cancers (HC) who are intrinsically more prone to infections and/or bleeding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11737091	We further investigated the impact of DBF4 on the progression of ccRCC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "further", "investigated", "the", "impact", "of", "DBF4", "on", ...
PMC11599565	At least 2 × 10 events were acquired in each measurement to account for sufficient cell number for analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "least", "2", "×", "10...
PMC11412721	The transcriptional program of a WT and two lymphoma-associated Myc mutants were recently compared, and we noticed that one of the mutants led to an alteration in Mt2 expression (Mahani et al., 2021), which would abrogate any potential prognostic value.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11587606	Mechanistically, RHBDF1 not only promotes tyrosine-phosphorylation of PKCζ, but also interacts with Tyr-p-PKCζ and importin β1 to facilitate the translocation of PKCζ into the nucleus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640555	We also observed that expression levels of pro-inflammatory mediators, such as iNOS and COX-2, were reduced by CX-4945 treatments at all concentrations (5, 10, and 15 μM) (Figure 3D and Figure 3E densitometric analysis Figure 3(D1) and Figure 3(E1), respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519077	In differentiated MSCs into the adipocyte lineage, relative mRNA levels of the PPARγ were considerably greater (p < 05; ANOVA) than in undifferentiated MSCs as a control (Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742431	TCGA database analysis of Furin gene expression levels across pan cancer. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TCGA", "database", "analysis", "of", "Furin", "gene", "expression", "levels", "a...
PMC10818573	In the second step, the probe, nfo, and nfo buffer were added to the amplification product from the previous step, and the reaction was carried out at 39 °C for 15 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11499955	The significant presence of VEGF-A at the surface of tumoral cells has been evidenced by numerous studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "significant", "presence", "of", "VEGF-A", ...
PMC7709199	Despite the decrease in glycan size, the CSF-1–CSF-1RD1–D3 complex retained a solubility close to that of the wild-type material and could be concentrated to 7.4 mg ml.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11361748	In addition to CXCR2, neutrophils under stress also express CXCR3 (see S3D Fig and refs ); besides, CXCL9 and CXCL11 expression shows a dependence upon K17 in stressed human and mouse keratinocytes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11380454	Importantly, these beneficial effects were associated with decreased tumor PD-L1 expression and increased CD8 positive T-cell infiltration in the tumor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", ...
PMC8524093	Understanding the most affected tissues and cell types allows the development of reproducible, validated, and robust cellular and animal models to study CHIKV infection in the pursuit of helping the development of therapeutic and vaccine options to manage CHIKF.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11271278	P values were derived from two-sided t-tests.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "values", "were", "derived", "from", "two-sided", "t-tests", "." ] } ]
PMC10812665	Briefly, enzymatic conversion of glucose or lactate resulted in the formation of colorimetric products, which were subsequently quantified through spectrophotometric measurements and compared to calibration standards.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

J. Villarrubia, M. Wasserstein, A. Barbato, R. C. Gallagher, R. Giugliani, N. B. Guelbert, J. B. Hennermann, C. Hollak, T. Ikezoe, R. Lachmann, O. Lidove, P. Mabe, E. Mengel, M. Scarpa, E. Senates, M. Tchan, B. L. Thurberg, A. Yarramaneni, A. M. Rawlings, Y. Kim, M. Kumar Hematology, Hospital Universitario Ramón y Cajal, Madrid, Spain; Children’s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, United States of America; Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy; Pediatrics, University of California, San Francisco, CA, United States of America; Med Genet Serv & DR BRASIL Research Grp, HCPA, Dept Genetics, UFRGS & INAGEMP, Porto Alegre, Brazil; Reina Fabiola University Clinic, Córdoba, Argentina; Pediatric and Adolescent Medicine, Villa Metabolica, University Medical Center, Mainz, Germany; Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands; Hematology, Fukushima Medical University, Fukushima, Japan; Charles Dent Metabolic Unit, National Hospital for Neurology and Neurosurgery, London, United Kingdom; La Croix St Simon Hospital, Paris, France; Clinica Santa Maria, Santiago, Chile; Clinical Science for LSD, SpinCS, Hochheim, Germany; Regional Coordinator Centre for Rare Diseases, University Hospital of Udine, Udine, Italy; Istanbul Medeniyet University, Istanbul, Turkey; Genetic Medicine, Westmead Hospital, Sydney, Australia; Sanofi, Cambridge, MA; Sanofi, Bridgewater, NJ, United States of America; Sanofi, Paris, France Background: Acid sphingomyelinase deficiency (ASMD) is a rare debilitating lysosomal storage disease characterized by pulmonary dysfunction, hepatosplenomegaly, thrombocytopenia/bleeding issues, and dyslipidemia.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11216402

As GC cell lines have no matched germline samples, CNVs were call against a nonmatched normal sample.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "GC", "cell", "lines", "have", ...

PMC11476264

Compared with FBXO11 knockdown alone, FBXO11 and ZEB1 double knockdown increased E-cadherin and decreased N-cadherin protein expression, which is similar to the result of ZEB1 knockdown alone (Figure 5A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11766174

CA-ICC was validated with HIV-infected cell lines and primary cells, and its application was tested with blood samples collected from animal models.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CA-ICC"...

PMC9509578

Hypoxia triggers cancer MDR by reducing the efficacy of chemotherapeutic drugs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hypoxia", "triggers", "cancer", "MDR", "by", "reducing", "the", "efficacy", "of", "ch...

PMC11643361

All compounds exhibited anticancer activity in the micromolar range, and Ru(II) scorpionates 46 and 47 exhibited antiproliferative activity comparable to that of cisplatin.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11335267

p < 0.01; Studentʼs t-test (n = 8 mice per genotype). (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.01", ";", "Studentʼs", "t-test", "(", "n"...

PMC11461833

HERVK induces cellular senescence and inflammation by activating the cGAS-STING pathway.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HERVK", "induces", "cellular", "senescence", "and", "inflammation", "by", "activating", "th...

PMC11633763

For instance, Circ‐CTNNB1 promotes m6A modification by interacting with RBM15 in osteosarcoma cells to drive glucose metabolism reprogramming .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "instance", ",", "Circ‐CTNN...

PMC6617630

MYC, BCL2, and BCL6 rearrangements were analyzed using break-apart FISH.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MYC", ",", "BCL2", ",", "and", "BCL6", "rearrangements", "were", "analyzed", ...

PMC11247842

We also included CpG islands from the UCSC genome browser.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "included", "CpG", "islands", "from", "the", "UCSC", "genome", "browser", "."...

PMC11590005

Additionally, the desire to be socially acceptable may also have interfered with the responses .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "the", "desire", "to", "be", "socially"...

PMC10222971

In view of the results obtained, it can be drawn that the most cytotoxic naphthoquinone derivative in all the cell lines tested is the derivative 5-O-acyl juglone (6), with a percentage of viable cells of 18.3%, 0.5%, and 7.2% on IGROV-1, SK-MEL-28, and HEK-293 cells, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11457557

Previous family clustering studies in the Diabetes Control and Complications Trial (DCCT) cohort have shown that those individuals with a strong family history of severe DR had an OR of 3.1 .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11024707

Venous blood samples from patients, siblings and children in the control group were collected in ethylenediamine tetraacetic acid (EDTA) tubes, independent of variables such as time, hunger, and satiety.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11799620

However, prevention can help to manage this toxicity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "prevention", "can", "help", "to", "manage", "this", "toxicity", "." ] } ]

PMC11451940

However, the obtained data showed an intriguing tapestry of redox processes occurring during the oxidation and reduction of the copper(ii) complexes 2 and 3, zinc(ii) complex 5, and free lapachol.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11248911

Non-bonded interactions were treated with a 12 Å cutoff distance and the neighbor searching list was buffered with the Verlet cutoff-scheme and the long-range electrostatic interactions were treated with the particle mesh Ewald (PME) method.

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PMC9429973

Buccal epithelium swab was taken an OLDANS plastic-viscose probe-tampon (Russia).

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PMC11714165

Subsequently, cells were digested using 0.25% trypsin, resuspended in PBS, and subjected to quantitative analysis of delivery efficiency using flow cytometry (CytoFLEX, BECKMAN, USA).

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PMC10777969

Human prostate normal PTEN2 cells were cultured in RPMI 1640 (Sigma) medium supplemented with penicillin–streptomycin mix (Sigma), 2 mM glutamine (Sigma), and fetal bovine serum (BII).

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PMC9532503

The LpHT output was subjected to further purification by anion exchange (AEX) chromatography using Q-sepharose FF (GE healthcare, USA).

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PMC11481779

For detailed per-chromosome results, see Supplementary Fig. 4.

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PMC11766309

Afterward, we combined the findings of the survival study with those of the DFI and DSS analyses, and the findings, which were fundamentally identical to the results from the OS and DFI analyses, revealed that a high expression of YKT6 was strongly linked to a poorer prognosis in cancer patients.

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PMC9429973

Odzharova, A. Semenova, G. Tumyan, E. Osmanov, T. Byalik Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); pathomorphology; oncohematology; radiology, «N.N. Blokhin Medical Research Center of Oncology», Moscow, Russia Background: Richter syndrome is a transformation of chronic lymphocytic leukemia into DLBCL, occurring in about 2-15% of patients (pts) with CLL.

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PMC9878562

Moreover, VAL-wt support in vitro chemotaxis of VAL cells in which ACKR3 was genetically deleted (VAL-ko).

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PMC9429973

Eighty-nine per cent of patients had B-cell non-Hodkin lymphoma.

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PMC5600151

Many kinds of dendrimers have been explored for nucleic acid or drug delivery, including poly(amidoamine) dendrimers , poly(propylene imine) dendrimers , poly(l-lysine) dendrimers , carbosilane dendrimers , and triazine dendrimers .

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PMC11706776

p < 0.05; **: p < 0.01 (Mann–Whitney tests). (

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PMC8978939

Assessed by RT-qPCR, mRNA levels showed that VHL-P138R-Venus and VHL-L163R-Venus variants were similar and even higher than VHL-WT-Venus mRNA levels ( Figure 1B ), suggesting that transcription levels are not responsible for the differences in protein levels evidenced by Western blot.

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PMC9910796

As a control, immature particles with a well-defined core shell as well as full nucleoid-containing virions were detected under permissive conditions (S4A–S4D Fig).

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PMC10114490

E Intracellular levels of reduced glutathione (GSH) and S-adenosyl-L-methionine (SAM) in diHLC-T and HepG2 cells.

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PMC11269933

After 2-3 days, growth transformants were inoculated into (-Leu, -Trp) medium and allowed to grow overnight at 30°C with continuous shaking at 200 rpm.

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PMC11781181

IHC staining was performed overnight at 4 °C as described previously using rabbit polyclonal anti-FSP1 (diluted 1:400, PA5-28727, Thermo), mouse monoclonal anti-4-hydroxynonenal (4-HNE) (diluted 1:100, ab48506, Abcam), rabbit monoclonal anti-transferrin receptor (TFRC; diluted 1:400, ab214039, Abcam), rabbit monoclonal anti-six-transmembrane epithelial antigen of the prostate 3 (STEAP3) (diluted 1:100, D164478, sangon biotech), rabbit monoclonal anti-ACSL4 (diluted 1:200, ab155282, Abcam), rabbit monoclonal anti-ALOX15 (diluted 1:800, ab244205, Abcam), rabbit monoclonal anti-FTH1 (diluted 1:400, ab183781, Abcam), mouse monoclonal anti-8-hydroxy-2′-deoxyguanosine (8-OHdG) (diluted 1:200, ab48508, Abcam), rabbit polyclonal anti-NCOA4 (diluted 1:200, ab111885, Abcam), mouse monoclonal anti-LPCAT3 (diluted 1:200, ab239585, Abcam), mouse monoclonal anti-divalent metal transporter 1 (DMT1) (diluted 1:200, ab55735, Abcam), and rabbit monoclonal anti-IgG isotype control (ab172730, Abcam) antibodies.

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PMC11746942

Analysis revealed that S1PR3 was mainly localized to the epidermal layer, whereas S1PR2 and S1PR1 were primarily expressed in dermal fibroblasts and endothelial cells, respectively (Fig. 2C).

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PMC7229095

However, further checks are needed to determine whether these conditions are also capable of growing non-producers, which may not be the case since the Picked/Growth ratio was similar (~ 30%).

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PMC11643491

The solutions with the droplets were stirred for 3 h to ensure complete solvent evaporation.

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PMC11298021

To further confirm the transfection efficiency, flow cytometry was performed to determine the exact number of FAM-labeled (transfected) cells.

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PMC9429973

Aims: Here we present neoantigen evaluations from reprocessing de novo Multiple Myeloma patients recruited into the CoMMpass study.

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PMC10604092

Notably, the locomotor activities of the force-fed SLC-transplanted rats decreased over time (Figure 6H).

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PMC11300639

Data are presented as the mean ± SEM of three replicates.

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PMC11739670

Differences in the MHCIα3 domain are unlikely to be the main contributors to changes in the binding affinities for two reasons.

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PMC11680049

However, when the callus tissue was cultivated for 12 cycles, a gradual browning was observed, yet the callus retained a high growth rate, with light areas forming in the central part (Figure 5d,e).

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PMC11655536

As shown in Fig. 1F, HA significantly decreased the viability of the MM cell lines, and the inhibition effect is dose-dependent.

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PMC9436459

MDAAs with a prenyl group or a modified prenyl group at C-7″ of the methylcyclohexene ring were rare, and only six examples have been reported.

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PMC11795610

All data are expressed as mean ± SD (n = 3). **

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PMC11489175

A role for DUBs in supporting the growth of tumor cells resistant to platinum agents emerges from the literature.

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PMC6835428

Indeed, particles with diameters greater than 10 nm are scarcely drained by the blood vessels (see Section 2.2).

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PMC11714165

Intercepting the detrimental interplay between osteoclasts and osteosarcoma cells is considered as an option for osteosarcoma treatment.

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PMC11588008

Therefore, we use the PM active metabolite of CTX for experimental research in later experiments.

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PMC11610461

Kidney renal clear cell carcinoma (KIRC) is one of the most prevalent subtypes of KC, accounting for more than 80% of cases of renal malignancy (Hsieh et al., 2017; Brozovich et al., 2021).

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PMC11629192

These therapies are initiated early in the disease course, often at diagnosis, with the primary objective of reducing relapse frequency and slowing the progression of disability.

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PMC11453295

In addition, we hope to identify mediators that drive estrogen-induced tumorigenesis using the mouse mammary intraductal (MIND) model, which better recapitulates the progression of ILC and response to estrogen in vivo.

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PMC10565698

This study screened a novel circRNA, hsa_circRNA_101889 (circUSP10), upregulated in LC.

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PMC11337594

The error bars represent the means ± SDs (n = 3). (

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PMC9429973

Aims: Thromboembolic prophylaxis is critical in managing COVID-19 patients on ECMO.

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PMC11748618

Training data was limited to individuals of African Ancestry to reduce effects of population stratification.

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PMC10587429

Class II biological safety cabinet. -

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PMC11594588

The development of molecular techniques has allowed for the identification of new molecules as potential biomarkers of diagnostic, prognostic, and therapeutic importance.

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PMC10854447

Found: C, 63.38; H, 3.91; N, 22.03.

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PMC11286266

The identity of the CHO-K1 cell lines has been authenticated by successfully targeting essential genes using a species-specific CRISPR whole-genome library and sequencing the WT or mutant alleles of the genes studied, which confirmed the sequences reported for the corresponding genome.

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PMC11615828

Precise perturbation of endocytosis to inhibit virus entry.

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PMC11394227

Annexin V-PE/7-AAD apoptosis detection kit (Vazyme, Nanjing, China) was used for the determination.

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PMC9429973

Results: Thirty-five hospitals/clinics are currently participating to REALYSA across France.

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PMC8540611

HL-60 and CEM-SS cells were more resistant to the effects of AuNP.

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PMC11786767

∗∗P < 0.01; ∗∗∗P < 0.001; one-way ANOVA.

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PMC8873393

Then RNA-seq from the pool of three biological replicates was performed of the resulting cytoplasmic fraction and chromatin pellet extract, yielding at least 180 million uniquely mapped reads from each sample (Table S1).

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PMC11609529

ImageJ was utilized to analyze and quantify staining-positive cells in sections of individual tumors (n = 6 in each group, mean ± SD).

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PMC11772585

β-Tubulin was used for the normalization control.

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PMC11770130

For human NTSR2, NTS behaved as a neutral antagonist in COS cells and HEK293 cells but an activator of MEK-ERK signaling in CHO cells.

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PMC11422150

The hAMSC treatment suppressed the local accumulation of macrophages at SCI (Figure 3).

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PMC9429973

NKG2D is an activating receptor on NK cells that recognizes ligands on the surface of tumor cells and plays a crucial role in tumor cell killing.

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PMC6024716

The polyamine content and protein concentration was determined for each sample.

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PMC9512971

Two patients in the camostat mesilate group discontinued treatment due to adverse drug reactions (hepatic function abnormal and drug eruption).

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PMC10854447

The newly designed 1,2,4-oxadiazoles 7a–o were considered to be sterically fixed counterparts of the previously discovered linear carboximidamide derivatives 6a–o (Figure 2).

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PMC9429973

Preclinical studies suggest that CBL-mutant cells are dependent on FLT3 signaling.

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PMC6799808

a–c A549 and A427 cells were treated with GLPT for 24 h, rapamycin (Rapa) for 2 h or AZD8055 for 2 h at the indicated concentrations, and western blotting was then performed with the indicated antibodies.

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PMC11583690

The SI value was calculated using the following formula (5):(5)SI = (IC50 of normal cells)/(IC50 of cancer cells) Here, “normal cells” refer specifically to the Hs68 cell line, while “cancer cells” include the VcAP, A549, and MCF-7 cell lines .

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PMC6650823

These findings raise the hope that the prevention of CF-related pathologies may be possible before or soon after birth with timely administration of targeted therapies.

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PMC9813422

Moreu et al. observed that HBV tethering at CGIs was not affected in HBV-ΔX, suggesting that HBx does not drive the tethering of HBV cccDNA in the host chromosomes (56).

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PMC11429241

For the A2780 cell line, although all the cells migrated to the scaffold, better attachment was observed with a pore size of 40 µm.

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PMC11298021

Research on clinical models and trials has demonstrated the anti-cancer properties of rapamycin, one of the mTOR inhibitors currently available.

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PMC11675244

Segments of Frizzled (Fzd) receptors have also been shown to enhance Wnt inhibition, as Fzd7 fractions were found to reduce β-catenin-dependent gene transcription in HCC .

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PMC9429973

Methods: 15 pts were enrolled (Table 1).

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PMC9429973

On the other hand, there is scarce data regarding the safety and efficacy of HDC in patients with hematological cancers (HC) who are intrinsically more prone to infections and/or bleeding.

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PMC11737091

We further investigated the impact of DBF4 on the progression of ccRCC cells.

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PMC11599565

At least 2 × 10 events were acquired in each measurement to account for sufficient cell number for analysis.

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PMC11412721

The transcriptional program of a WT and two lymphoma-associated Myc mutants were recently compared, and we noticed that one of the mutants led to an alteration in Mt2 expression (Mahani et al., 2021), which would abrogate any potential prognostic value.

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PMC11587606

Mechanistically, RHBDF1 not only promotes tyrosine-phosphorylation of PKCζ, but also interacts with Tyr-p-PKCζ and importin β1 to facilitate the translocation of PKCζ into the nucleus.

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PMC11640555

We also observed that expression levels of pro-inflammatory mediators, such as iNOS and COX-2, were reduced by CX-4945 treatments at all concentrations (5, 10, and 15 μM) (Figure 3D and Figure 3E densitometric analysis Figure 3(D1) and Figure 3(E1), respectively).

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PMC11519077

In differentiated MSCs into the adipocyte lineage, relative mRNA levels of the PPARγ were considerably greater (p < 05; ANOVA) than in undifferentiated MSCs as a control (Figure 4).

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PMC11742431

TCGA database analysis of Furin gene expression levels across pan cancer. (

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PMC10818573

In the second step, the probe, nfo, and nfo buffer were added to the amplification product from the previous step, and the reaction was carried out at 39 °C for 15 min.

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PMC11499955

The significant presence of VEGF-A at the surface of tumoral cells has been evidenced by numerous studies.

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PMC7709199

Despite the decrease in glycan size, the CSF-1–CSF-1RD1–D3 complex retained a solubility close to that of the wild-type material and could be concentrated to 7.4 mg ml.

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PMC11361748

In addition to CXCR2, neutrophils under stress also express CXCR3 (see S3D Fig and refs ); besides, CXCL9 and CXCL11 expression shows a dependence upon K17 in stressed human and mouse keratinocytes .

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PMC11380454

Importantly, these beneficial effects were associated with decreased tumor PD-L1 expression and increased CD8 positive T-cell infiltration in the tumor.

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PMC8524093

Understanding the most affected tissues and cell types allows the development of reproducible, validated, and robust cellular and animal models to study CHIKV infection in the pursuit of helping the development of therapeutic and vaccine options to manage CHIKF.

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PMC11271278

P values were derived from two-sided t-tests.

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PMC10812665

Briefly, enzymatic conversion of glucose or lactate resulted in the formation of colorimetric products, which were subsequently quantified through spectrophotometric measurements and compared to calibration standards.

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