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OTAR3088
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PMC11767725
Elevated leptin in obesity promotes Th17 cell polarization, while decreased adiponectin removes an anti-inflammatory control, further fueling psoriatic inflammation .
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PMC11306019
At 1.5 μM, 1,3,6-triGG significantly inhibited BTZ-induced cytotoxicity (6.25 nM), while the combination of 1.5 μM GA and 1.5 μM 2′,6′-diGG did not show comparable effects (Figure 3A).
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PMC11585254
Di-leucine motifs, which are recognized by AP2 on the CT of several chemokine receptors, have been linked to agonist-stimulated internalization (Fan et al., 2001; Kraft et al., 2001; Orsini et al., 1999).
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PMC11723947
To analyze cytokine production by memory T cell, cells were first stimulated with 10 ng/mL PMA and 1 μg/mL Ionomycin in the presence of 5 μg/mL BFA.
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PMC11657695
p < 0,05 and **: p < 0,01 (Mann–Whitney test) KCNA2/Kv1.2 is involved in the regulation of the Hippo signaling pathway.
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PMC11787381
Effect of formulated bambuterol (green) on the neuronal survival (NeuN) in the CA1 area of the hippocampus.
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PMC9429973
Owing to the time of recruitment and the policy of our hospital, none of the patients were evaluated by geriatrics or palliative care at diagnosis.
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PMC8978939
To date, pVHL’s most described function is its interaction and consequent downregulation of HIF-α protein subunits (53).
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PMC11488203
The ligand SDF-1 remained undetectable and expression of GAPDH served as a control (B).
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PMC11762280
The positive staining of MPO, MMP9, and F4/80 showed no differences between Ac-DEVD-CHO-treated mice and PBS-treated mice, indicating similar levels of neutrophils and macrophages infiltration in both groups (Fig. 4E).
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PMC9917080
The mixing of the laser beam on the target was carried out along a given trajectory in the form of parallel straight lines inscribed in a rectangle using an LScanH galvanomechanical scanner (Ateko-TM, Russia).
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PMC4369959
Consumption of diet rich in plant products may be one of the important reasons for the low incidence of cancer in Asia.
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PMC11343332
The study employs various molecular assays to assess apoptosis-related markers such as p53 activation and changes in Bcl-2 family proteins.
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PMC11711063
LY294002 was a kind gift from Dr. Zoltán Balajthy.
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PMC9429973
Summary/Conclusion: Our findings unveil FGF23 as the missing link between hematopoiesis and bone homeostasis in a congenital hemolytic anemia, as a condition of chronic EPO stimulation.
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PMC11723210
Furthermore, time-lapse imaging of COS-7 cells in vitro highlights the method’s robustness and capability for long-term quantitative analysis of large cell populations.
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PMC9429973
The choice of 1st line TKI (IM vs 2G) was not influenced by the Sokal, Euro, EUTOS or ELTS scores.
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PMC6312945
Srivastava et al (19) also reported that the downregulation of miR-345 expression level is conducive to pancreatic cancer cell apoptosis.
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PMC11634027
Values were normalized to the average in controls and plotted using GraphPad Prism.
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PMC11753949
Little is known about the functions of these ER subdomains, although there is evidence that the spine apparatus may have a role in synaptic plasticity.
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PMC10852540
At 72 hours, cell activity decreased markedly for most concentrations.
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PMC8348645
Test for Terpenoids: Salkowki’s test: We placed 0.2 mL of plant extract in a test tube with 0.2 mL of chloroform.
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PMC7053076
The incidence of acute myeloid leukemia (AML) and heterogeneous clonal disorders of hematopoietic progenitor cells are increasing worldwide .
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PMC11699042
Subsequently, the values of overlapping WGS intervals within each CCLE interval were aggregated by calculating the mean CN for all overlapping WGS intervals.
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PMC9429973
Cox regression was used to identify prognostic factors for PFS.
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PMC11488203
According to altered proliferative capacities of different tumor entities, more rapidly growing cancer cells including the A549 lung carcinoma, MDA-MB-231 breast carcinoma, and SK-OV-3 ovarian cancer cells were incubated for 72 h while the slower proliferating HT-29 colon adenocarcinoma and CCF-STTG1 astrocytoma cells were treated for 168 h, respectively.
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PMC11531735
These female mice were randomly divided into distinct treatment groups, each comprising 15 mice.
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PMC11696576
We tested whether mutations to 114 validated cancer driver genes represented by at least 3 cell lines in the CCLS were associated with a significant shift in the IC50 of the inhibitors.
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PMC11612315
Both GLP-1 analogs and exendin 9–39 were found to reduce CAP-induced inward currents and calcium influx through the TRPV1 channel.
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PMC11515150
We screened the membrane-proximal domain VHH targeting CD5 associating with engineered human NK cells, followed by lentiviral transduction with a fourth generation CD5-CAR resulting in 12 C CAR-NK cells that exhibited excellent cell lysis properties against T cell malignancy in vitro and in vivo.
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PMC10589262
Seven-week-old male BALB/c-nude mice were purchased from Orient Bio (Gyeonggi, South Korea).
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PMC11451829
Additionally, an increase in the number of proinflammatory molecules related to UV irradiation may contribute to pterygium formation.
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PMC11761919
As shown in Fig. 6B, chickens in the infection control and Micro control group exhibited depression and began to die at 3 dpi, with mortality increasing at 5 dpi and peaking at 9 dpi, resulting in a survival rate of 60%.
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PMC2614416
Under the auspices of Virginia Commonwealth University Office of Research Subjects Protection, compliance with U.S. Department of Health and Human Services (Office for Human Research Protection) regulations at 45 CFR 46.101(b)(4) was provided by Fitzgerald Industries.
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PMC11087055
PIV analysis is described in the following part.
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PMC9429973
Summary/Conclusion: This case report illustrates a case with acquired hemophilia A with delayed diagnosis and development of a life-threatening condition where the treatment was prolonged and the outcome uncertain.
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PMC11721277
Residual solvent was used as the reference standard for spectra calibrating.
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PMC11593031
Since a comprehensive cytogenomic characterization of murine tumor cell lines can be performed using murine multicolor banding (mcb) in combination with molecular karyotyping , the first detailed karyotypes for the murine NB cell line Neuro-2a and its derivatives Neuro2a TR-alpha and Neuro2a TR-beta are presented.
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PMC11489275
And the difference between survivors and non-survivors was more obvious over time.
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PMC9429973
Allo-HCT is a potentially curative treatment for acute myeloid leukemia (AML) and Acute lymphoblastic leukemia (ALL).
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PMC9429973
A relatively low percentage of patients, 7%, underwent leukapheresis but eventually did not receive axi-cel.
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PMC11173119
We found that the morphology of macrophages derived from iPSCs of a patient with the MEFV mutation significantly differed from that of macrophages derived from iPSCs of a healthy donor carrying the wild-type MEFV gene.
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PMC6600253
Most of these compounds have beneficial health effects, including antioxidative, anti-inflammatory, neuroprotective, cardiovascular protective, antiaging, and chemopreventive effects .
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PMC9621239
The ratios of cells in the S phase among the Vector, WT, SM, DM and TM groups are presented on the right at the top of the panel in (A) or (B); Each symbol represents an individual experiment.
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PMC11138140
Cultures were either left untreated or stimulated with 10 μM norepinephrine (A0937, Sigma) for 24 h to induce cardiomyocyte hypertrophy.
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PMC9429973
Our results showed that SLIT2 treatment reduced the cell proliferation and colony formation capacity and induced cell cycle retention in the G1 phase for all AML cell lines.
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PMC9096373
The incidence of gastrointestinal toxicity is higher at stages 3 and above (9).
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PMC6948907
In another report, biphasic effect of GE on prostatic cancer cell has been observed (El Touny et al., 2009).
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PMC3203927
It is a well known fact that astrocytes play a trophic role in supporting neurons.
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PMC11681005
The ChrAcc of single BLCA cells in hypoC3 and hypoC7 increased in basal cancer cells relative to luminal cancer cells and further increased in TPCS (Figure 1D,E).
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PMC3122064
Nutlin-3 in combination with cisplatin resulted in much higher Fas membrane expression levels compared with the levels found after treatment with Nutlin-3 or cisplatin alone in wild-type p53-expressing TC cell lines (Figure 6d and Supplementary Figure 5c).
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PMC7351993
The cells were cultured on culture dishes (100 mm in diameter, 150464, Thermo Fisher) and subcultured by 10-fold dilution 2–3 times per week before cultures become 60% confluent.
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PMC11473750
a Frequency of segmental copy number variation (loss [blue], gain [red]) across Chromosome 11 (10 kilobase genomic bins), from whole-genome sequencing of somatic tumour DNA (WGS) from the TARGET neuroblastoma patient cohort (n = 135).
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PMC10243817
Atopic status was evaluated by using the skin prick test with a standard panel of inhalant allergens common in our region and/or using ImmunoCAP to detect IgE Abs against common inhalant allergens (Phadia) (47).
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PMC11767817
Samples were analyzed using a BD FACS Lyric (Becton, Dickinson and Company, Franklin Lakes, NJ, USA), and the data were processed using FlowJo 10 (Becton, Dickinson and Company, Franklin Lakes, NJ, USA).
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PMC9429973
Finally, in vitro killing assays showed an increased cytotoxicity of both human and murine T cells in the presence of IL-27, while serum protein quantification showed a decrease in the levels of IL-27 in both CLL patients (E) and sick mice (F) when compared to their healthy counterparts.
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PMC11703992
T cells were extracted from the annotated scRNA data, and then the dimension reduction and unsupervised clustering were implemented again.
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PMC9429973
The median time to the first hematologic remission was 7 days (range 7-21) and the median time to ≥VGPR was 14 days (range 7 days – 3 months).
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PMC5173112
In conclusion, the present study provides evidence demonstrating that USP21 is significantly upregulated in CSCs of RCC cell lines.
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PMC7570809
In detail, 40,000 cells/well were seeded and incubated in the presence of peptides for 24 h. The CI was calculated by measuring the slope of the proliferation curve between two selected time points for each curve, considering that the maximum CI values observed is the end-point of the experiments.
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PMC7022782
Transmission electron microscopy (TEM) analysis demonstrated the cytoplasmic presence of coated vesicles (Ø ≤ 100 nm), hypothesizing their involvement in the mechanism of endocytosis.
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PMC11790599
The enlarged image showing TSL-induced vacuoles appearing mostly empty bound by single membrane (blue asterisks).
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PMC9351137
The quantitative analysis of defects scored in RNAi-treated and control cells (Table 2) is based on the following numbers: at least 100 prometaphases and metaphases for MS, 70 metaphases for CM and ASM, 300 telophases for LIB and CB, and 5500 interphases for MC.
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PMC9910796
Immuno-EM of control (+IPTG) and defective (-IPTG) vEP84Ri particles at budding areas.
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PMC11723947
d Representative dot-plots showing the percentage of HLA-B7 WT and HP1γ KO human Tconv producing IFN-γ and GM-CSF.
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PMC9429973
The complete remission and overall survival remain lower than that of the literature.
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PMC10391797
A combination of current strategies with CAR-T cell therapy may generate a promising response; for example, the application of PD1/PDL-1 antibodies, HDACi, or DNA methyltransferase (DNMT) inhibitor.20 Blockade of immune checkpoints inhibitors could reverse tumor cell-mediated dysfunction of antitumor effector cells and consequently of tumor escape from the host immune system.
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PMC11802855
F CXCL7 was mainly expressed in mm03 subgroup.
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PMC11342785
TPPP is a 24 kDa protein that promotes microtubule nucleation, bundling, and stabilization in oligodendrocytes.
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PMC10728535
Four expression profiles were excluded from this work due to being treated with temsirolimus; (3) GSE23553, which included RNA expression profiles of one cisplatin‐sensitive, A2780S, and one cisplatin‐resistant A2780CP cell line. (
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PMC9429973
Image: Summary/Conclusion: Despite a small sample of patients, the following trends were noted: 1 - patients with the initial stages of MF with similar clinical and histological features, are diverse in the number of tumor T-lymphocytes infiltrating the skin (from 0.26% to 83.4%); 2 - the initial stage of MF with the minimal disseminated disease, might have an unfavorable outcome; 3 - comparing to PCR-FA NGS might not provide further improvement in the specificity and sensitivity of T-cell clonality evaluation for the differential diagnosis in MF.
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PMC11682172
The specifications of the BBB in vitro model were published.
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PMC9583612
Figures S2–S7 and S13 indicate that CEMS can detect small methane concentration enhancements on the order of 1 ppm.
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PMC11186948
Surprisingly, when we investigated HDAC2 total protein abundance in #249 compared to HD LCLs we found it significantly reduced (Fig. 4B).
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PMC9429973
Results: Transplantation of CNC cells into C57BL/6 mice induced an aggressive Mac1/Gr1/c-Kit leukemia within 7 weeks, similar to the initial model (Bereshchenko et al, 2009).
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PMC6034753
Meq, the major oncoprotein of MDV, induces neoplastic transformation of T cells through several mechanisms, including inhibition of apoptosis [10–12, 35].
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PMC11703896
scale bar = 100 μm) Cytotoxic effect of rapamycin was studied against four different cancer cell lines and the most significant effect was observed against A549 lung cancer cell line.
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PMC11477621
H NMR (600 MHz, CDCl3) δ 7.25–7.23 (m, 1H), 7.21 (dd, J = 8.9, 4.3 Hz, 1H), 7.09 (d, J = 3.1 Hz, 1H), 6.94 (td, J = 9.1, 2.5 Hz, 1H), 6.42 (d, J = 3.0 Hz, 1H), 4.06 (t, J = 7.0 Hz, 2H), 2.04 (t, J = 7.5 Hz, 2H), 1.79 (p, J = 7.1 Hz, 2H), 1.57 (p, J = 7.4 Hz, 2H), 1.30–1.23 (overlap, 4H).
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PMC10253553
Transient transfection was carried out with 100 nM of non-targeting short interfering RNA (siRNA) (Dharmacon, Lafayette, CO, USA, D-001810-10-05), Rictor siRNA I (Cell Signaling Technology, Danvers, MA, USA, 8649), Rictor siRNA II (Cell Signaling Technology, 8622), and Lipofectamine RNAiMAX (Thermo Fisher Scientific, 13778075) in serum-free RPMI-1640 (786-O cells) or keratinocyte-free media (HK-2 cells) for six hours, after which they were maintained in RPMI-1640 with 10% FBS (for 786-O cells) or keratinocyte-free media with bovine pituitary extract (50 µg/mL) and EGF (for HK-2 cells) for 72 to 96 h. HK2 and 786-0 cells were treated with rapamycin or Torin 2 (at 2, 10, 50, 250, and 1000 nM) in complete HK2 or 786-0 media, respectively, for 24 h for western blot and RNA studies and 96 h for cell viability studies.
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PMC11477621
The mixture was stirred at room temperature overnight.
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PMC11569208
.
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PMC11679033
Regarding apoptosis induction by CIT, findings of studies with other cell models suggest that it originates from stimulating cytochrome c release followed by activation of multiple caspases in HL-60 cells .
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PMC11295144
Application of β2 ECD slightly decreased the synapse formation albeit not significantly (median = 4.67%; IQR = 2.67 – 7.35%; n = 20 cells; from N = 2 independent experiments).
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PMC11496491
After FPKM standardization, Researchers can compare the expression levels of different genes and the genes in different samples.
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PMC10898159
In fact, KIT expression was observed in 95% of GIST, as a diagnostic algorithm using upfront immunohistochemistry (IHC) markers of KIT (CD117) positivity in GIST , and with IM treatment, KIT transcript or/ and protein derived from multiple heterogeneous KIT mutations in IM-resistant cells is higher than that in pre-IM counterparts [31–33], implying the compensatory up-regulation of KIT possibly contributing to secondary resistance to IM.
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PMC11724582
Functional enrichment analysis was performed for the downregulated genes; that is, their expression was upregulated in NSCLC cells after the acquisition of osimertinib resistance.
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PMC8839885
Moreover, combining platinum with fisetin restored platinum drug sensitivity to OC cells co-cultured with MSC by re-activating ERK1/2 activity .
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PMC11544771
Goat anti-rabbit IgG-horseradish peroxidase (HRP) and goat anti-mouse IgG-HRP were purchased from Pierce (Rockland, IL, USA).
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PMC10840195
Key proteins related to proliferation, migration and invasion were detected by WB (F).
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PMC9250505
Similar directional changes were observed in the expression and foci formation of γH2AX or RAD51 in OVCAR433 cells treated with NPB-Olaparib (Supplementary Fig. 5C).
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PMC10940855
Genetically engineered cells (shRNA, dCas9-VPR, and gRNA) were grown in media containing 4 μg/mL of puromycin (Sigma-Aldrich, P9620) and/or 8 μg/mL of blasticidin (Thermo Fisher Scientific, A1113903), depending on the resistance of the plasmids.
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PMC9429973
G. Cristiano, J. Nanni, L. Zannoni, C. Sartor, S. Parisi, S. Paolini, C. Papayannidis, M. Cavo, A. Curti Hematology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna; Hematology, IRCCS Azienda ospedaliero-universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy Background: Absolute lymphocyte count (ALC) is known to be an independent prognostic factor for overall survival (OS) in patients receiving autologous transplantation for Hodgkin’s and non-Hodgkin’s lymphomas, multiple myeloma and breast cancer.
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PMC11422497
RT-qPCR, reverse transcription- quantitative PCR.
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PMC11366496
Cell growth curves were determined employing CCK‐8 assay between sh‐NC and sh‐RNF122#2. (
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PMC7192625
In this mode, ChAseR returns a matrix of values, which can be visualized as a heatmap highlighting which types of features are found to be in preferentially interacting chromatin fragments, either with one feature on each of the interacting fragments, or with both features on interacting fragments (Figure 4C, D).
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PMC9275501
Self-assembled micelles can adjust the ratio of the two drugs and optimize the synergistic effect of drug combinations by using a simple co-assembly strategy, which is simple and feasible.
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PMC11442172
Media formulations mimicking the nutrient concentrations in plasma or the direct microenvironment can improve the biological relevance of in vitro cancer modeling and aid in addressing the metabolic discrepancies between in vivo and in vitro systems.
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PMC11423992
cells were purchased from MILESTONE (Shanghai, China).
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PMC10329237
Effect of BLM, PFD, and LOS on A549 viability Several concentrations of BLM (0.05, 0.1, 0.2, and 0.5 µg/ml) were used in A549 cells and cell viability was evaluated by MTT assay to determine the optimal concentration of BLM for treating A549 cells to prevent excessive cell death.
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PMC8469018
The resulting retention times for teriflunomide (A771726) and the internal standard were averaged 5.7 and 8.8 min respectively.
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