OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11106977	Plasticity in energy metabolism enables BMSCs to meet the different demands of osteo-adipogenic differentiation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plasticity", "in", "energy", "metabolism", "enables", "BMSCs", "to", ...
PMC11774747	However, this method requires long expansion periods, often taking at least three weeks with repeated restimulations, which can also lead to more differentiated and exhausted T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874	Shown is the arithmetic average of triplicate measurements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Shown", "is", "the", "arithmetic", "average", "of", "triplicate", "measurements", "." ] } ]
PMC9429973	Regarding ELN2017 classification, 68% of patients were classified into the favorable, 29% intermediate and 3% adverse risk groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regardi...
PMC11095939	shLuc served as a negative control. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "shLuc", "served", "as", "a", "negative", "control", ".", "(" ] } ]
PMC10565698	F. Dual-luciferase assay to verify circUSP10 and miR-211-5p binding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F.", "Dual-luciferase", "assay", "to", "verify", "circUSP10", "and", "miR-211", "-", ...
PMC10243817	Type I collagen and type V collagen are fibril-forming collagens and type IV collagen is nonfibrillar and participates in basement membrane thickening in vertebrates (43).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7305184	Each generation cells were electroporated in transferred to a new growing flask.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "generation", "cells", "were", "electroporated", "in", "transferred", "to", ...
PMC11618052	The diazotization of aniline derivatives (6a–d) with NaNO2/HCl at 0–5 °C, followed by the addition of sodium azide, resulted in the formation of the corresponding aromatic azides (7a–d) with a yield of 70–75%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11360263	PGCCs manifest across a spectrum of malignant solid tumors, encompassing melanoma, urothelial carcinoma, renal cell carcinoma, breast and ovarian cancer, pancreatic carcinoma, prostate carcinoma , as well as hematologic malignancies such as leukemia .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	Recently, knockdown and knockout approaches have suggested that CXCR4 endocytosis occurs via a β-arrestin independent mode.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recently", ",", "knockdown", "and", "knockout", ...
PMC9429973	Vamifeport as a single therapy or in combination with repeated BTs increased Hb, RBC counts, hematocrit and decreased spleen size, reticulocyte counts, plasma erythropoietin and α-globin aggregates in RBCs of Hbb mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10006224	RNA Quality scores were 9.9 on average (range 9.1–10) when assayed on a PerkinElmer LabChip analyzer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "Quality", "scores", "were", "9....
PMC11684297	The medical bionanotechnology field has expanded rapidly in the past few decades, bringing up several theranostic solutions for a spectrum of diseases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11469524	Furthermore, it indicates that the BCR signaling network structure developed from BL-2 data can be seen as the most representative BCR signaling structure for BL cells activated by a crosslink of the BCR (Fig 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6379402	We generate ER networks by fixing the number of nodes, n, and by randomly adding edges between uniformly chosen pairs of nodes (out of the n(n−1)/2 possible pairs of nodes) until a given density is reached.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585565	Relative mRNA levels of wild-type and mutant CNNM4 at 24- and 48-hours post-transfection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "mRNA", "levels", "of", "wild-type", "and", "mutant", "CNNM4", ...
PMC11694066	Appropriate silencing of EWS–WT1 was verified as shown in Fig. 4H.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Appropriate", "silencing", "of", "EWS", "–", "WT1", "was", "verified", ...
PMC11774251	Psoriasis is a systemic disease resulting from the interplay of genetic, environmental and immunologic factors, with incidence rates rising annually.1 It is marked by recurring red, thick, scaly skin plaques, causing discomfort like itching and pain.2 In addition, patients with psoriasis often suffer from comorbidities, such as psoriatic arthritis, cardiovascular disease, psychiatric disorders, and metabolic syndrome.3 Therefore, effective treatments for psoriasis are needed to alleviate symptoms and reduce complications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8839885	The efflux transporters ABCB1 and ABCG2 have been demonstrated to interact with tyrosine kinase inhibitors (TKIs) such as dasatinib, and to reverse drug-resistance in human multidrug-resistant multiple myeloma cells mediated by Src inhibition .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8806312	The terms of CC were as follows: receptor complex, neuronal cell body membrane, and cell body membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "terms", "of", "...
PMC11610461	The F-test was used to compare the differences between samples, and p < 0.05 was considered as a statistically significant difference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "F-tes...
PMC10958426	High CV genes are defined as the 2000 genes with the highest CV of gene expression in cancer cells of each patient.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "High", "CV",...
PMC9429973	The international prognostic index was 2 to 5 for 486 patients (76.2%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "international", "prognostic", "index", "was", "2", "...
PMC7841067	Finally, the in vivo nude mice model confirmed that knockdown of AKAP4 attenuated tumor growth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "the", "in", "vivo", "nude", "mic...
PMC9429973	Results: A total of 317.9K conversations on SCD were detected, mainly on Twitter (93%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "A", "t...
PMC8584666	Pantetheinase hydrolyzes pantetheine to produce pantothenic acid and cysteamine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pantetheinase", "hydrolyzes", "pantetheine", "to", "produce", "pantothenic", "acid", "and", "cysteamine", "...
PMC11569208	There are previous reports suggesting a role for ACP2 in regulating herpes-simplex virus (HSV) cellular entry, but none directly describing its role in regulating the antiviral defense response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10047551	Despite the fact that the cg04478497 and cg00975815 methylation levels were not correlated with PD-L1 mRNA expression in the NSCLC cell lines, we questioned whether a correlation was present in the NSCLC tumor tissue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11045125	The level of p53 protein expression in stable cell lines derived from the ΔEBNA2 + Myc lymphomas is similar to that expressed in EBV-transformed LCLs (Fig 3D), while the p53-deleted Akata BL line as expected lacks p53 expression, and the Mutu I and P3HR1 BL cell lines (both of which have mutant p53) have massively increased p53 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10297204	Statistical analysis was performed with a comparative test of Kruskal–Wallis followed by a Steel–Dwass post hoc analysis utilizing the Excel Statistics software package for Windows (Version 2022; Social Survey Research Information Co., Ltd., Tokyo, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Conversely, loss of TET2 leads to reduced GATA2 levels, which is restored by 5-azacytidine treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conversely", ",", "loss", "of", "TET2", "le...
PMC11216402	COL1A1_E1, COL1A1_E2, and FGF5_E are all bound by RUNX2 and JUN in LPS141 (Bevill et al. 2023).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "COL1A1_E1", ",", ...
PMC10968586	In human triple negative breast cancer cells MDA-MB-231, HT seemed to lose effectiveness with respect to time, with IC50 values changing from 107.17 μM to 183.65 μM in 72 h .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988555	However, it is interesting to note that, generally the C resonances of the complexes generally do not follow the same order as the respective H signals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	Arpin- and Pla2g4a-conditional-knockout mice were generated by Centre d’Immunophénomique using CRISPR–Cas9 technology and were crossed in our animal facility with Itgax-cre mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC6267596	In total 2,225 and 2,149 proteins were identified that passed a minimum of two peptides identified at 0.1% peptide FDR and 90-99.9% protein confidence by the Protein Profit algorithm, within Scaffold respectively for U2932 and VAL cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11540664	In the high-L group, patients in the TKI+PD1 group showed longer mPFS compared with those who received TKIs [3.5 months, (95%CI 0.1–14.1) versus 2.9 months (95%CI 1.6–4.2), p = 0.036], and mOS [22.9 months, (95%CI 1.4–44.5) versus 7.9 months, (95%CI 0.1–16.0) p = 0.031; Figures 2A, B ].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11060216	SPSS26.0 was used to collect and analyze data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SPSS26.0", "was", "used", "to", "collect", "and", "analyze", "data", "." ] } ]
PMC11798926	In fact, they only occur when surface HA-GluA1 is labelled with primary antibody and then incubated at 37°C for 20–30 min, allowing the receptor to internalize.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739504	Statistical analyses were conducted using GraphPad Prism 5 software (GraphPad, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analyses", "were", "conducted", "using", "GraphPad", "P...
PMC9429973	All patients are off treatment; no new SAEs of any kind have occurred since the primary analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "patients", "are", "off", "treat...
PMC11401350	A Schematic representation of the mCD8-LVs and the anti-mCD4 expressing CAR encoding vector constructs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Schematic", "representation", "of", "the", "mCD8-LVs", "and", ...
PMC10747160	Then, 50 μL of SARS-CoV-2 pseudovirus solution was added over the top of the wells, and the 96-well plate was subsequently returned to the 37 °C humidified incubator at 4.5% CO2 in order to allow the HEK-293T-hACE2+ cells and Raji cells to undergo infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	No. 301-1) and coelenterazine 400a (cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No.", "301", "-", "1", ")", "and", "coelenterazine", "400a", "(", "cat", "." ] } ]
PMC10713411	The diagram shows PCD-related DEGs (\|logFC\| >2.0, adjusted P-value < 0.05). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "diagram", "shows", "PCD-related", "DEGs", "(", ...
PMC10587429	Plot the human CD45+ cells in a BV421 x PE view to visualize human T and B cell development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plot", "the", "human", ...
PMC10671321	EctoLRP4 corresponds to the extracellular domain of human LRP4 fused to a 6xHis-tag at the COOH terminus and was generated by Genescript from full length human LRP4 sequence inserted in a pcDNA3 plasmid (gift from Stephan Kröger).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11363012	We previously showed that natural product profiles of C. roseus did not change substantially after protoplast isolation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "previously", "showed", "that", "natural", ...
PMC11484188	Similarly, circular RNAs targeting and inhibiting miR-1343-3p enhance TGFβ/Smad3/epithelial-mesenchymal transition (EMT) signaling, resulting in deterioration of non-small cell lung cancer (NSCLC) and ovarian cancer (10).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11483468	To assess whether the reduction in GST-TAT-LPTS39-associated cell growth was induced by cell death, the cell death rate of BEL-7404 and Hela cells was analysed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "...
PMC9105697	Especially in small, localized tumors, this fraction of ctDNA is often less than 0.01% of cfDNA, which is below the detection threshold of most assays .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640115	All statistical analyses were performed using EZR (version 3.6.3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "statistical", "analyses", "were", "performed", "using", "EZR", "(", "version", ...
PMC10850553	The images of immunofluorescent staining of control arterial walls or IA lesions for C5AR1 (green), nuclear staining by DAPI (blue), and merged images are shown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9952933	U2-OS and A673 cells were cultured in Dulbecco’s modified Eagle’s medium (DMEM) containing 1.0 g/L glucose, 10% fetal bovine serum, 1 mM sodium pyruvate, and 1% penicillin/streptomycin (all reagents from PAN Biotech, Aidenbach, Germany).	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11706776	Maximum of fluorescence (peak of Ca influx F340/F380) was measured and compared to normal condition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Maximum", "of", "fluorescence", "(", "peak", ...
PMC11724582	The data from the acute group and DTP group of H1975 cells were analyzed for differential expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "from", "the", "acute", ...
PMC11672142	Observed changes in the % cell viability of Jurkat cells treated with caspase-dependent apoptosis and ferroptosis inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Observed", "changes", "in", "the", "%", ...
PMC9429973	Eligible pts have a diagnosis of BPDCN and are to be treated (or have recently started treatment) with TAG monotherapy as 1L treatment, per physician’s decision.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	M. Pesova, V. Mancikova, R. Helma, S. Pavlova, V. Hejret, P. Taus, J. Hynst, K. Plevova, J. Kotaskova, J. Malcikova, S. Pospisilova Central European Institute of Technology (CEITEC), Masaryk University; Department of Internal Medicine - Hematology and Oncology, Faculty of Medicine of Masaryk University and University Hospital; Institute of Medical Genetics and Genomics, Faculty of Medicine, Masaryk University, Brno, Czechia Background: Presence of defects in the TP53 gene represents a clinically relevant biomarker in chronic lymphocytic leukemia (CLL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612794	Asterisk indicates nonspecific bands.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Asterisk", "indicates", "nonspecific", "bands", "." ] } ]
PMC11468365	Table 4The performance of the MultiComb model to predict sensitivity score taskPerformance metrics MeanStdMeanStdMeanStdMeanStdMeanStdMeanStdMultiComb15.591.853.940.232.740.140.900.010.950.010.950.01The best-performing results are shown in bold The performance of the MultiComb model to predict sensitivity score task The best-performing results are shown in bold Also, the score of MultiComb for sensitivity is equal to 0.90 to ensure an acceptable performance model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4395774	Perforin expressed from the PGK.PRF vector exhibited the correct conformation of precursor and mature forms typically noted in lysates from NK and CTL (YT shown for comparison, Supplementary Figure S2a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9812014	Emetine was found to severely limit NDV replication in a cell-free endogenous virus polymerase assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Emetine", "was", "found", "to", "severely", "limit", "NDV",...
PMC7759933	After the fixation step, the cells were washed in cold PBS, centrifuged, and labelled with anti-KI67-FITC (50-fold diluted antibodies in 1% BSA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11726848	This made it possible to reduce the subjectivity of assessment and more accurately assess the size and shape of the formed plumes, which is especially important given the need to collect data on a large number of plumes in each sample (https://cometbio.org/, accessed on 28 November 2024).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8998437	The type II BL cell lines maintained some GC B cell markers, including CD10, but expressed EBV genes of the latency III program .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9143157	However, PARPi can be mainly used as maintenance therapy following the first-line platinum-containing treatment regimen because the cytotoxic efficacy is limited.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",...
PMC11670407	Mechanistically, OTULIN maintains the stability of the GPX4 protein by regulating the ubiquitination level of GPX4, thereby conferring resistance to cisplatin in osteosarcoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11269933	The anti-His tag antibody was immobilized onto the CM5 sensor chip surface according to the instructions of the Amine Coupling Kit (GE Healthcare, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	NEAT1 expression was assessed by qRT-PCR and RNA-FISH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NEAT1", "expression", "was", "assessed", "by", "qRT-PCR", "and", "RNA-FISH", "." ] } ]
PMC11802855	To classify genes with similar expression profiles into gene modules, we conducted average linkage hierarchical clustering according to the TOM-based dissimilarity measure with a minimum gene group size of 30 for the genes dendrogram.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9592219	Each transfection was performed in triplicate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "transfection", "was", "performed", "in", "triplicate", "." ] } ]
PMC9545474	F NMR (376 MHz, D2O): δ −63.01 ppm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", "NMR", "(", "376", "MHz", ",", "D2O", "):", "δ", "−63.01", "ppm", "."...
PMC11240448	Therapeutic strategies to inhibit a mutated or overexpressed oncogene rarely work as anticipated, because of combinatorial molecular interactions leading to the activation of alternative signaling pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11457557	In addition, ENPP1 polymorphism was associated with integrated reporting (IR) in a meta-analysis conducted in patients with T2DM detected a significant association between the ENPP1K121Q polymorphism and increased susceptibility of DKD in European and Asian populations .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087766	In contrast, chimalliviruses face selection pressures from both other chimalliviruses and the host, likely shaping the evolution of distinct import selectivities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11638255	g Representative images of merged OPAL multiplex immunofluorescence spectra depicting the tumoral distribution of NCR1 natural killer cells (red), CD8 cytotoxic T cells (yellow), CD11b myeloid (white) and DAPI nuclei stain (blue) in NXS2 neuroblastoma tumor tissue 14 days post-treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794847	This relationship becomes critically pertinent as HVEM appears to modulate T cell metabolic shifts via GPT2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "relationship", "becomes", "critically", "pertinent",...
PMC11593084	Cells were harvested using 0.25% trypsin and 1 mM ethylenediamine tetraacetic acid (EDTA; Nacalai).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "harvested", "using", ...
PMC10547921	Peptides can affect the efficiency of PDC internalization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Peptides", "can", "affect", "the", "efficiency", "of", "PDC", "internalization", "." ] } ]
PMC8662250	The incubation with increasing concentration (0.1–10 ng/ml) of SP caused a concentration‐dependent decrease of cell viability (−21%, −47% and −72% vs. vehicle group, respectively) at 24 h in cultured Caco‐2 cells by MTT analysis (Figure 1a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4443654	Our data show that accurate predictions of Hi-C-derived eigenvector values, and the nuclear compartment domains based upon them, are entirely feasible.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", ...
PMC10582828	It should be noted that, differently from the original strains, the Omicron strains caused high mortality rates in Asian populations but not in Western European populations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6379402	Software used in the paper are publicly available at http://www0.cs.ucl.ac.uk/staff/natasa/iCell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Software", "used", "in", "the", "paper", "are", "publicly", "available", "at", "http://www0.cs.u...
PMC11773391	Patients with advanced MM progress rapidly and experience a poor prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "with", "advanced", "MM", "progress", "rapidly", "and", "experience", "a", ...
PMC11638288	These residues allow the binding of NKp46 to immunoreceptor tyrosine-based activation motifs (ITAMs) containing FcεRIγ and CD3ζ, leading to the phosphorylation of tyrosine residues and subsequent signal transduction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Hazard ratios (HRs) and 95% CIs for time-to-event endpoints (DOR, PFS, and OS) were computed using a weighted Cox proportional hazards model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11566417	Cells were then split into three technical replicates by seeding at 2 × 10 cells in 3 T25 flasks in EpSC medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "wer...
PMC11469524	By analyzing subcellularly fractionated cell lysates, it can be shown that both cytosolic as well as nuclear pERK is increased in the presence of the p38 inhibitor SB203580 in α-IgM-stimulated BL-2 cells (Fig 3C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11555465	At 72 h, the inhibition rates of the RH experimental group and ToxoDB#9 experimental group reached 18.57 and 35.24%, respectively and the inhibition rate of T. gondii culture supernatant stimulated at the same time in the ToxoDB#9 experimental group was higher than that of the RH experimental group (P<0.01; Table I).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640419	The cytotoxicity of the synthesized compounds was evaluated on one adherent and three suspension cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cytotoxicity", "of", "the", "synthesized", "com...
PMC9429973	Results: We enrolled 569 patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "We", "enrolled", "569", "patients", "." ] } ]
PMC10907726	Based on our findings, it is indicated that DATS may primarily modulate the proliferation of OS cells mainly by promoting the PD-L1 and PD-1 checkpoint pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11633763	Three independent experiments were performed. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "independent", "experiments", "were", "performed", ".", "*" ] } ]
PMC11401350	Additionally, we characterized the CD8 T cells in vivo by staining for activation (CD69) and verification of cytotoxicity and naïve/memory status of the CAR + and CAR- CD8 T cells at experimental endpoint (Fig. 5G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092382	Lamiaceae]).	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Lamiaceae", "]", ")", "." ] } ]
PMC11672881	For RNA sequencing (RNAseq), 3 µg of RNA from each sample was utilized.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "RNA", "sequencing", "(", "RNAseq", ")", "...
PMC10553757	Reference: (1) Rostom, H. et al. Protocol for an observational study investigating hormones triggering the onset of sustained lactation: the INSIGHT study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543853	Control cells were vitrified using the same procedure, except for adding the virus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Control", "cells", "were", "vitrified", "using", "the", "same", ...

PMC11106977

Plasticity in energy metabolism enables BMSCs to meet the different demands of osteo-adipogenic differentiation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plasticity", "in", "energy", "metabolism", "enables", "BMSCs", "to", ...

PMC11774747

However, this method requires long expansion periods, often taking at least three weeks with repeated restimulations, which can also lead to more differentiated and exhausted T cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11188874

Shown is the arithmetic average of triplicate measurements.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Shown", "is", "the", "arithmetic", "average", "of", "triplicate", "measurements", "." ] } ]

PMC9429973

Regarding ELN2017 classification, 68% of patients were classified into the favorable, 29% intermediate and 3% adverse risk groups.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regardi...

PMC11095939

shLuc served as a negative control. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "shLuc", "served", "as", "a", "negative", "control", ".", "(" ] } ]

PMC10565698

F. Dual-luciferase assay to verify circUSP10 and miR-211-5p binding.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F.", "Dual-luciferase", "assay", "to", "verify", "circUSP10", "and", "miR-211", "-", ...

PMC10243817

Type I collagen and type V collagen are fibril-forming collagens and type IV collagen is nonfibrillar and participates in basement membrane thickening in vertebrates (43).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7305184

Each generation cells were electroporated in transferred to a new growing flask.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "generation", "cells", "were", "electroporated", "in", "transferred", "to", ...

PMC11618052

The diazotization of aniline derivatives (6a–d) with NaNO2/HCl at 0–5 °C, followed by the addition of sodium azide, resulted in the formation of the corresponding aromatic azides (7a–d) with a yield of 70–75%.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11360263

PGCCs manifest across a spectrum of malignant solid tumors, encompassing melanoma, urothelial carcinoma, renal cell carcinoma, breast and ovarian cancer, pancreatic carcinoma, prostate carcinoma , as well as hematologic malignancies such as leukemia .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11544122

Recently, knockdown and knockout approaches have suggested that CXCR4 endocytosis occurs via a β-arrestin independent mode.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recently", ",", "knockdown", "and", "knockout", ...

PMC9429973

Vamifeport as a single therapy or in combination with repeated BTs increased Hb, RBC counts, hematocrit and decreased spleen size, reticulocyte counts, plasma erythropoietin and α-globin aggregates in RBCs of Hbb mice.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10006224

RNA Quality scores were 9.9 on average (range 9.1–10) when assayed on a PerkinElmer LabChip analyzer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "Quality", "scores", "were", "9....

PMC11684297

The medical bionanotechnology field has expanded rapidly in the past few decades, bringing up several theranostic solutions for a spectrum of diseases .

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PMC11469524

Furthermore, it indicates that the BCR signaling network structure developed from BL-2 data can be seen as the most representative BCR signaling structure for BL cells activated by a crosslink of the BCR (Fig 1C).

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PMC6379402

We generate ER networks by fixing the number of nodes, n, and by randomly adding edges between uniformly chosen pairs of nodes (out of the n(n−1)/2 possible pairs of nodes) until a given density is reached.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11585565

Relative mRNA levels of wild-type and mutant CNNM4 at 24- and 48-hours post-transfection.

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PMC11694066

Appropriate silencing of EWS–WT1 was verified as shown in Fig. 4H.

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PMC11774251

Psoriasis is a systemic disease resulting from the interplay of genetic, environmental and immunologic factors, with incidence rates rising annually.1 It is marked by recurring red, thick, scaly skin plaques, causing discomfort like itching and pain.2 In addition, patients with psoriasis often suffer from comorbidities, such as psoriatic arthritis, cardiovascular disease, psychiatric disorders, and metabolic syndrome.3 Therefore, effective treatments for psoriasis are needed to alleviate symptoms and reduce complications.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8839885

The efflux transporters ABCB1 and ABCG2 have been demonstrated to interact with tyrosine kinase inhibitors (TKIs) such as dasatinib, and to reverse drug-resistance in human multidrug-resistant multiple myeloma cells mediated by Src inhibition .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8806312

The terms of CC were as follows: receptor complex, neuronal cell body membrane, and cell body membrane.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "terms", "of", "...

PMC11610461

The F-test was used to compare the differences between samples, and p < 0.05 was considered as a statistically significant difference.

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PMC10958426

High CV genes are defined as the 2000 genes with the highest CV of gene expression in cancer cells of each patient.

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PMC9429973

The international prognostic index was 2 to 5 for 486 patients (76.2%).

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PMC7841067

Finally, the in vivo nude mice model confirmed that knockdown of AKAP4 attenuated tumor growth.

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PMC9429973

Results: A total of 317.9K conversations on SCD were detected, mainly on Twitter (93%).

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PMC8584666

Pantetheinase hydrolyzes pantetheine to produce pantothenic acid and cysteamine.

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PMC11569208

There are previous reports suggesting a role for ACP2 in regulating herpes-simplex virus (HSV) cellular entry, but none directly describing its role in regulating the antiviral defense response.

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PMC10047551

Despite the fact that the cg04478497 and cg00975815 methylation levels were not correlated with PD-L1 mRNA expression in the NSCLC cell lines, we questioned whether a correlation was present in the NSCLC tumor tissue.

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PMC11045125

The level of p53 protein expression in stable cell lines derived from the ΔEBNA2 + Myc lymphomas is similar to that expressed in EBV-transformed LCLs (Fig 3D), while the p53-deleted Akata BL line as expected lacks p53 expression, and the Mutu I and P3HR1 BL cell lines (both of which have mutant p53) have massively increased p53 expression.

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PMC10297204

Statistical analysis was performed with a comparative test of Kruskal–Wallis followed by a Steel–Dwass post hoc analysis utilizing the Excel Statistics software package for Windows (Version 2022; Social Survey Research Information Co., Ltd., Tokyo, Japan).

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PMC9429973

Conversely, loss of TET2 leads to reduced GATA2 levels, which is restored by 5-azacytidine treatment.

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PMC11216402

COL1A1_E1, COL1A1_E2, and FGF5_E are all bound by RUNX2 and JUN in LPS141 (Bevill et al. 2023).

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PMC10968586

In human triple negative breast cancer cells MDA-MB-231, HT seemed to lose effectiveness with respect to time, with IC50 values changing from 107.17 μM to 183.65 μM in 72 h .

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PMC10988555

However, it is interesting to note that, generally the C resonances of the complexes generally do not follow the same order as the respective H signals.

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PMC11224020

Arpin- and Pla2g4a-conditional-knockout mice were generated by Centre d’Immunophénomique using CRISPR–Cas9 technology and were crossed in our animal facility with Itgax-cre mice.

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PMC6267596

In total 2,225 and 2,149 proteins were identified that passed a minimum of two peptides identified at 0.1% peptide FDR and 90-99.9% protein confidence by the Protein Profit algorithm, within Scaffold respectively for U2932 and VAL cell lines.

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PMC11540664

In the high-L group, patients in the TKI+PD1 group showed longer mPFS compared with those who received TKIs [3.5 months, (95%CI 0.1–14.1) versus 2.9 months (95%CI 1.6–4.2), p = 0.036], and mOS [22.9 months, (95%CI 1.4–44.5) versus 7.9 months, (95%CI 0.1–16.0) p = 0.031; Figures 2A, B ].

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PMC11060216

SPSS26.0 was used to collect and analyze data.

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PMC11798926

In fact, they only occur when surface HA-GluA1 is labelled with primary antibody and then incubated at 37°C for 20–30 min, allowing the receptor to internalize.

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PMC11739504

Statistical analyses were conducted using GraphPad Prism 5 software (GraphPad, USA).

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PMC9429973

All patients are off treatment; no new SAEs of any kind have occurred since the primary analysis.

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PMC11401350

A Schematic representation of the mCD8-LVs and the anti-mCD4 expressing CAR encoding vector constructs.

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PMC10747160

Then, 50 μL of SARS-CoV-2 pseudovirus solution was added over the top of the wells, and the 96-well plate was subsequently returned to the 37 °C humidified incubator at 4.5% CO2 in order to allow the HEK-293T-hACE2+ cells and Raji cells to undergo infection.

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PMC11544122

No. 301-1) and coelenterazine 400a (cat.

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PMC10713411

The diagram shows PCD-related DEGs (|logFC| >2.0, adjusted P-value < 0.05). (

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PMC10587429

Plot the human CD45+ cells in a BV421 x PE view to visualize human T and B cell development.

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PMC10671321

EctoLRP4 corresponds to the extracellular domain of human LRP4 fused to a 6xHis-tag at the COOH terminus and was generated by Genescript from full length human LRP4 sequence inserted in a pcDNA3 plasmid (gift from Stephan Kröger).

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PMC11363012

We previously showed that natural product profiles of C. roseus did not change substantially after protoplast isolation.

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PMC11484188

Similarly, circular RNAs targeting and inhibiting miR-1343-3p enhance TGFβ/Smad3/epithelial-mesenchymal transition (EMT) signaling, resulting in deterioration of non-small cell lung cancer (NSCLC) and ovarian cancer (10).

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PMC11483468

To assess whether the reduction in GST-TAT-LPTS39-associated cell growth was induced by cell death, the cell death rate of BEL-7404 and Hela cells was analysed.

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PMC9105697

Especially in small, localized tumors, this fraction of ctDNA is often less than 0.01% of cfDNA, which is below the detection threshold of most assays .

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PMC11640115

All statistical analyses were performed using EZR (version 3.6.3).

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PMC10850553

The images of immunofluorescent staining of control arterial walls or IA lesions for C5AR1 (green), nuclear staining by DAPI (blue), and merged images are shown.

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PMC9952933

U2-OS and A673 cells were cultured in Dulbecco’s modified Eagle’s medium (DMEM) containing 1.0 g/L glucose, 10% fetal bovine serum, 1 mM sodium pyruvate, and 1% penicillin/streptomycin (all reagents from PAN Biotech, Aidenbach, Germany).

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PMC11706776

Maximum of fluorescence (peak of Ca influx F340/F380) was measured and compared to normal condition.

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PMC11724582

The data from the acute group and DTP group of H1975 cells were analyzed for differential expression.

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PMC11672142

Observed changes in the % cell viability of Jurkat cells treated with caspase-dependent apoptosis and ferroptosis inhibitors.

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PMC9429973

Eligible pts have a diagnosis of BPDCN and are to be treated (or have recently started treatment) with TAG monotherapy as 1L treatment, per physician’s decision.

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PMC9429973

M. Pesova, V. Mancikova, R. Helma, S. Pavlova, V. Hejret, P. Taus, J. Hynst, K. Plevova, J. Kotaskova, J. Malcikova, S. Pospisilova Central European Institute of Technology (CEITEC), Masaryk University; Department of Internal Medicine - Hematology and Oncology, Faculty of Medicine of Masaryk University and University Hospital; Institute of Medical Genetics and Genomics, Faculty of Medicine, Masaryk University, Brno, Czechia Background: Presence of defects in the TP53 gene represents a clinically relevant biomarker in chronic lymphocytic leukemia (CLL).

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PMC11612794

Asterisk indicates nonspecific bands.

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PMC11468365

Table 4The performance of the MultiComb model to predict sensitivity score taskPerformance metrics MeanStdMeanStdMeanStdMeanStdMeanStdMeanStdMultiComb15.591.853.940.232.740.140.900.010.950.010.950.01The best-performing results are shown in bold The performance of the MultiComb model to predict sensitivity score task The best-performing results are shown in bold Also, the score of MultiComb for sensitivity is equal to 0.90 to ensure an acceptable performance model.

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PMC4395774

Perforin expressed from the PGK.PRF vector exhibited the correct conformation of precursor and mature forms typically noted in lysates from NK and CTL (YT shown for comparison, Supplementary Figure S2a).

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PMC9812014

Emetine was found to severely limit NDV replication in a cell-free endogenous virus polymerase assay.

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PMC7759933

After the fixation step, the cells were washed in cold PBS, centrifuged, and labelled with anti-KI67-FITC (50-fold diluted antibodies in 1% BSA).

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PMC11726848

This made it possible to reduce the subjectivity of assessment and more accurately assess the size and shape of the formed plumes, which is especially important given the need to collect data on a large number of plumes in each sample (https://cometbio.org/, accessed on 28 November 2024).

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PMC8998437

The type II BL cell lines maintained some GC B cell markers, including CD10, but expressed EBV genes of the latency III program .

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PMC9143157

However, PARPi can be mainly used as maintenance therapy following the first-line platinum-containing treatment regimen because the cytotoxic efficacy is limited.

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PMC11670407

Mechanistically, OTULIN maintains the stability of the GPX4 protein by regulating the ubiquitination level of GPX4, thereby conferring resistance to cisplatin in osteosarcoma cells.

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PMC11269933

The anti-His tag antibody was immobilized onto the CM5 sensor chip surface according to the instructions of the Amine Coupling Kit (GE Healthcare, USA).

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PMC9429973

NEAT1 expression was assessed by qRT-PCR and RNA-FISH.

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PMC11802855

To classify genes with similar expression profiles into gene modules, we conducted average linkage hierarchical clustering according to the TOM-based dissimilarity measure with a minimum gene group size of 30 for the genes dendrogram.

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PMC9592219

Each transfection was performed in triplicate.

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PMC9545474

F NMR (376 MHz, D2O): δ −63.01 ppm.

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PMC11240448

Therapeutic strategies to inhibit a mutated or overexpressed oncogene rarely work as anticipated, because of combinatorial molecular interactions leading to the activation of alternative signaling pathways.

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PMC11457557

In addition, ENPP1 polymorphism was associated with integrated reporting (IR) in a meta-analysis conducted in patients with T2DM detected a significant association between the ENPP1K121Q polymorphism and increased susceptibility of DKD in European and Asian populations .

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PMC11087766

In contrast, chimalliviruses face selection pressures from both other chimalliviruses and the host, likely shaping the evolution of distinct import selectivities.

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PMC11638255

g Representative images of merged OPAL multiplex immunofluorescence spectra depicting the tumoral distribution of NCR1 natural killer cells (red), CD8 cytotoxic T cells (yellow), CD11b myeloid (white) and DAPI nuclei stain (blue) in NXS2 neuroblastoma tumor tissue 14 days post-treatment.

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PMC11794847

This relationship becomes critically pertinent as HVEM appears to modulate T cell metabolic shifts via GPT2.

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PMC11593084

Cells were harvested using 0.25% trypsin and 1 mM ethylenediamine tetraacetic acid (EDTA; Nacalai).

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PMC10547921

Peptides can affect the efficiency of PDC internalization.

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PMC8662250

The incubation with increasing concentration (0.1–10 ng/ml) of SP caused a concentration‐dependent decrease of cell viability (−21%, −47% and −72% vs. vehicle group, respectively) at 24 h in cultured Caco‐2 cells by MTT analysis (Figure 1a).

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PMC4443654

Our data show that accurate predictions of Hi-C-derived eigenvector values, and the nuclear compartment domains based upon them, are entirely feasible.

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PMC10582828

It should be noted that, differently from the original strains, the Omicron strains caused high mortality rates in Asian populations but not in Western European populations.

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PMC6379402

Software used in the paper are publicly available at http://www0.cs.ucl.ac.uk/staff/natasa/iCell.

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PMC11773391

Patients with advanced MM progress rapidly and experience a poor prognosis.

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PMC11638288

These residues allow the binding of NKp46 to immunoreceptor tyrosine-based activation motifs (ITAMs) containing FcεRIγ and CD3ζ, leading to the phosphorylation of tyrosine residues and subsequent signal transduction.

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PMC9429973

Hazard ratios (HRs) and 95% CIs for time-to-event endpoints (DOR, PFS, and OS) were computed using a weighted Cox proportional hazards model.

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PMC11566417

Cells were then split into three technical replicates by seeding at 2 × 10 cells in 3 T25 flasks in EpSC medium.

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PMC11469524

By analyzing subcellularly fractionated cell lysates, it can be shown that both cytosolic as well as nuclear pERK is increased in the presence of the p38 inhibitor SB203580 in α-IgM-stimulated BL-2 cells (Fig 3C).

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PMC11555465

At 72 h, the inhibition rates of the RH experimental group and ToxoDB#9 experimental group reached 18.57 and 35.24%, respectively and the inhibition rate of T. gondii culture supernatant stimulated at the same time in the ToxoDB#9 experimental group was higher than that of the RH experimental group (P<0.01; Table I).

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PMC11640419

The cytotoxicity of the synthesized compounds was evaluated on one adherent and three suspension cell lines.

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PMC9429973

Results: We enrolled 569 patients.

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PMC10907726

Based on our findings, it is indicated that DATS may primarily modulate the proliferation of OS cells mainly by promoting the PD-L1 and PD-1 checkpoint pathways.

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PMC11633763

Three independent experiments were performed. *

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PMC11401350

Additionally, we characterized the CD8 T cells in vivo by staining for activation (CD69) and verification of cytotoxicity and naïve/memory status of the CAR + and CAR- CD8 T cells at experimental endpoint (Fig. 5G).

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PMC11092382

Lamiaceae]).

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PMC11672881

For RNA sequencing (RNAseq), 3 µg of RNA from each sample was utilized.

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PMC10553757

Reference: (1) Rostom, H. et al. Protocol for an observational study investigating hormones triggering the onset of sustained lactation: the INSIGHT study.

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PMC11543853

Control cells were vitrified using the same procedure, except for adding the virus.

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